ABSTRACT Objective: The risk of malignancy and diagnostic accuracy of fine-needle aspiration biopsy (FNAB) of thyroid nodules (TN) with diameters ≥ 3-4 cm remains controversial. However, some groups have indicated surgical treatment in these patients regardless of the FNAB results. We aimed to evaluate the diagnostic accuracy of the FNAB in systematically resected ≥4 cm TN and if the risk of malignancy is higher in these patients. Subjects and methods: We retrospectively evaluated 138 patients (142 nodules) with TN with diameters ≥4 cm who underwent thyroidectomy. Results: The FNAB results were nondiagnostic/unsatisfactory (ND/UNS) in 2.1% of the cases and benign in 51.4%. They indicated atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in 23.9% of cases, follicular neoplasia/suspicious for a follicular neoplasm (FN/SFN) in 9.2%, suspicion of malignancy (SUS) in 8.5%, and malignant in 4.9%. The histopathological analysis after thyroidectomy revealed a thyroid cancer rate of 100% in the FNABs classified as malignant, 33.3% in SUS cases, 7.7% in FN/SFN, 17.6% in AUS/FLUS, and 4.1% in benign FNABs. None of the ND/UNS FNABs were malignant. The global malignancy diagnosis was 14.8% (n = 21). However, the rate of false negatives for FNAB was low (4.1%). Conclusion: We showed that the risk of malignancy in nodules with diameters ≥4 cm was higher compared to the risk of thyroid cancer in TN in general. However, we found a low rate of false-negative cytological results; therefore, our data do not justify the orientation of routine resection for these larger nodules.

O objetivo deste trabalho foi caracterizar o desenvolvimento de cultivares de soja com diferentes grupos de maturação e tipos de crescimento em terras altas e terras baixas no Rio Grande do Sul. Foram conduzidas nove épocas de semeadura em Santa Maria (ambiente de terras altas) e uma época de semeadura em Capão do Leão (ambiente de terras baixas) durante os anos agrícolas 2010/2011, 2011/2012 e 2012/2013, com 11 cultivares de soja. O delineamento experimental em todos os experimentos foi blocos ao acaso, em parcelas subdivididas. Foi quantificada a duração, em ºC dia, do ciclo de desenvolvimento, da fase vegetativa e reprodutiva, e do período entre a data que ocorreu o início do florescimento e o número final de nós para todas as épocas e locais de semeadura. Houve redução da duração da fase reprodutiva, do ciclo total de desenvolvimento (exceto algumas cultivares semeadas em setembro), com o atraso da data de semeadura independentemente do grupo de maturação e tipo de crescimento. As semeaduras de setembro, janeiro e fevereiro promovem uma redução da fase vegetativa na maioria das cultivares quando comparadas com a época recomendada (novembro e dezembro). Cultivares indeterminadas apresentam um maior período de sobreposição das fases vegetativa e reprodutiva do que as cultivares determinadas em todas as épocas e locais de cultivo. O desenvolvimento da soja é similar quando cultivada em terras altas e terras baixas.

The objective of this study was to characterize the development of soybean cultivars with different maturity group, and growth types grown in highlands and in lowlands in Rio Grande do Sul. Field experiments were conducted in Santa Maria (highland) and Capão do Leão (lowland) during the 2010/2011, 2011/2012 and 2012/2013 growing seasons, with 11 treatments (soybean cultivars). Nine sowing dates were conducted in Santa Maria and one in Capão do Leão. The experimental design in all experiments was a randomized block design with split plots. The duration of the development cycle, vegetative and reproductive phases, and the period between the date that was the final number of nodes and early flowering was measured in °C day, for all sites and sowing dates. There was reduction in the duration of the reproductive phase, total development cycle (except some cultivars sown in september), with delay on sowing date regardless of the maturity group and type of growth with delayed sowing. Sowings of September, January and February promote a reduction in vegetative stage in most cultivars when compared with the recommended period (November and December). Cultivars Indeterminate have a longer period of overlap between the vegetative and reproductive phases than certain cultivars in all sites and sowing dates. The soybean development is similar when grown in highlands and lowlands.