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Novel Terpene-Reinforced Photopolymerizable Resins Derived from Methacrylate Salts of Imidazole TerpeneReinforced Terpene Reinforced
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Lins, Ilária M. S.

; Vieira, Anderson G.

; Ribeiro, Rubson P. S.

; Santos, Dayane K. D. N.

; Maciel, Larissa G.

; Santa-Cruz, Petrus A.

; Alves Júnior, Severino

; Anjos, Janaína V. dos

Journal of the Brazilian Chemical Society

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2025, Volume 36 Nº 5 elocation e-20240201

Resumo: En | Texto: En | PDF: En

This research aims to develop new 3D (three-dimensional) printable resins made from methacrylate salts of imidazole, 2-methyl-imidazole, and 1-methyl-imidazole, with glycerol trimethacrylate serving as a crosslinking agent. With their backbone structure, these resins are easy and rapid to prepare, offering an alternative to conventional ones. Reinforced with terpene-based additives such as α-pinene, (R)-limonene, trans-ethyl cinnamate, and safrole, they present a diverse range of fifteen resin formulations. Each resin underwent printability tests, including printing tests, which revealed accuracy, precision, and dimensional stability compared to a commercial resin and its respective digital 3D models. Mechanical tests further demonstrated that adding alpha-pinene and (R)-limonene enhanced hardness, while safrole had the opposite effect. Resins containing α-pinene and (R)-limonene as additives showcased an elasticity modulus comparable to the commercial resin. According to mechanical tests, a cytocompatibility assay was conducted for the best resin, showing that this resin holds potential for developing drug delivery systems and other biomedical devices. D threedimensional three (three-dimensional imidazole 2methylimidazole, 2methylimidazole methylimidazole 2 methyl 2-methyl-imidazole 1methylimidazole, 1methylimidazole 1 1-methyl-imidazole agent structure prepare ones terpenebased terpene based αpinene, αpinene α pinene, pinene Rlimonene, Rlimonene R limonene, limonene transethyl trans ethyl cinnamate formulations accuracy precision models alphapinene alpha hardness effect devices

https://doi.org/10.21577/0103-5053.20240201

Patients with genital ambiguity referred without a sex definition: the relationship between clinical picture and defined sex of rearing definition
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Santos, Henrique C.

; Barros, Beatriz A.

; El-Beck, Mayra S.

; Miranda, Marcio L.

; Guaragna, Mara S.

; Fabbri-Scallet, Helena

; Mazzola, Taís N.

; Vieira, Tarsis P.

; Mello, Maricilda P.

; Marques-de-Faria, Antonia P.

; Maciel-Guerra, Andrea T.

; Guerra-Junior, Gil

Jornal de Pediatria

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Dez 2024, Volume 100 Nº 6 Páginas 609 - 613

Resumo: En | Texto: En | PDF: En

Abstract Objective It was to verify the association between the definition of sex of rearing and, clinical and cytogenetic features among patients with genital ambiguity referred without a sex assignment. Methods The sample consisted of 133 patients with genital ambiguity seen at a single reference service. These patients did not have a defined social sex at the first consultation and their etiological diagnosis was obtained during follow-up. Results A total of 133 cases were included, 74 of which were reared as males and 59 as females. No correlation was found between the year of birth and the year of the first consultation with the definition of sex of rearing. However, the definition of sex of rearing was associated with age at the first consultation, severity of genital ambiguity, presence of palpable gonad(s), presence of uterus on ultrasound, karyotype, and diagnosis. Palpable gonad(s), more virilized genitalia, absence of a uterus on ultrasound, 46, XY karyotype, or a karyotype with sex chromosome abnormalities emerged as strong predictors for defining male sex. All 77 (58 %) patients over 18 years old had a gender identity in accordance with the sex of rearing; though 9 of 77 (12 %) had homo or bisexual orientation, especially girls with Congenital Adrenal Hyperplasia. Conclusions Clinical and cytogenetic data were strongly associated with the definition of the sex of rearing of children with genital ambiguity referred to a DSD center without sex assignment. Management in a specialized center allows the establishment of a gender identity in accordance with the sex of rearing. assignment 13 service followup. followup follow up. up follow-up included 7 5 females However gonads, gonads gonad s , gonad(s) ultrasound genitalia 46 58 (5 % 1 12 (1 orientation Hyperplasia gonad(s 4 (

https://doi.org/10.1016/j.jped.2024.05.001

Length-weight and length-length relationships of 10 fish species from headwater streams of the lower Iguassu River basin, Brazil Lengthweight Length weight lengthlength length 1 basin
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Genovai, Natalia

; Maciel, Anderson Luís

; Piana, Pitágoras Augusto

; Gubiani, Éder André

Zoologia (Curitiba)

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2024, Volume 41 elocation e23025

Resumo: En | Texto: En | PDF: En

ABSTRACT Length-weight (LWR) and length-length (LLR) relationships are widely used in management programs and monitoring of fish stocks. We estimated the LWR and LLR of 10 fish species sampled from nine streams of the lower reach of the Iguassu River Basin, Paraná, Brazil. All LWR fits were significant, with b values ranging from 2.37 to 3.62 and an average value of 3.07. Most species showed isometric growth. Significant differences in the LWR between sexes were observed only for Phalloceros harpagos Lucinda, 2008 in the Três Barras stream. All LLR fits were significant, with b values ranging from 0.98 to 1.25 and an average value of 1.15. Significant differences between sexes for the LLR were observed for Rhamdia voulezi Haseman, 1911 in the Arroio Passo Liso stream. First records of the LWR for four species - Ancistrus mullerae Bifi, Pavanelli & Zawadzki, 2009, Bryconamericus pyahu Azpelicueta, Casciotta & Almirón, 2003, Cambeva stawiarski (Miranda Ribeiro, 1968), and Cambeva taroba (Wosiacki & Garavello, 2004) - and the LLR for six species - A. mullerae, B. pyahu, C. davisi, C. stawiarski, C. taroba, and P. harpagos - and a new record of maximum standard length for two species - C. taroba and B. pyahu - are presented. Lengthweight Length weight (LWR lengthlength (LLR stocks 1 Basin Paraná Brazil significant 237 2 37 2.3 362 3 62 3.6 307 07 3.07 growth Lucinda 200 stream 098 0 98 0.9 125 25 1.2 115 15 1.15 Haseman 191 Bifi Zawadzki 2009 Azpelicueta Almirón 2003 Miranda Ribeiro 1968, 1968 , 1968) Wosiacki Garavello 2004 A B C davisi P presented 23 2. 36 6 3. 30 3.0 20 09 9 0. 12 1. 11 1.1 19 196

https://doi.org/10.1590/s1984-4689.v41.e23025

Coproparasitological research in birds housed at the Sargento Prata Zoo, Fortaleza - Ceará, Brazil Zoo Ceará
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Lemos, L. B. S.

; Marques, A. R.

; Lima, B. P.

; Dias, B. V. A.

; Fontão, C. C.

; Ribeiro, C. D. S.

; Freitas, C. M. P.

; Schwinden, G. M.

; Sampaio, I. F.

; Silva, I. N. G.

; Melo, L. S.

; Melo, M. V. C.

; Pascoal Filho, N. M.

; Alves, P. V.

; Teixeira, R. S. C.

; Maciel, W. C.

Brazilian Journal of Biology

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2024, Volume 84 elocation e286120

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Birds kept in captivity are subject to various diseases that affect their well-being, with parasites being among the most common. The aim of this study was to report the occurrence of endoparasites in the feces of birds kept in captivity at Fortaleza Zoo, using the Willis Mollay and Hoffman techniques. Of the samples analyzed, 50.98% were positive for endoparasites, including the suborder Coccidia, the genera Capillaria spp., Strongyloides spp., Ascaridia spp., Libyostrongylus spp., cysts of a specific parasite of Ostriches, Balantidium spp., the Strongyloidea superfamily and cestodes. In conclusion, the wild birds in the zoo investigated had a diversity of endoparasites and a considerable infection rate. wellbeing, wellbeing well being, well-being common Zoo techniques analyzed 5098 50 98 50.98 Coccidia spp spp. Ostriches cestodes conclusion rate 509 5 9 50.9 50.

Resumo As aves mantidas em cativeiro estão sujeitas a diversas enfermidades que afetam seu bem-estar, estando as parasitoses entre as mais frequentes. Este trabalho teve como objetivo relatar a ocorrência de endoparasitas em fezes de aves alojadas em cativeiro no zoológico de Fortaleza, utilizando as técnicas de Willis Mollay e de Hoffman. Das amostras analisadas, 50,98% foram positivas para endoparasitas, incluindo os da subordem Coccidia., os gêneros Capillaria spp., Strongyloides spp., Ascaridia spp., Libyostrongylus spp. (parasita específico de Avestruzes), cisto de Balantidium spp., superfamília Strongyloidea e cestódeos. Conclui-se que as aves silvestres do zoológico investigado apresentaram, além de uma diversidade de endoparasitas, uma considerável taxa de infecção. bemestar, bemestar bem estar, estar bem-estar frequentes Fortaleza Hoffman analisadas 5098 50 98 50,98 Coccidia Coccidia. spp parasita Avestruzes, Avestruzes , Avestruzes) cestódeos Concluise Conclui se apresentaram infecção 509 5 9 50,9 50,

https://doi.org/10.1590/1519-6984.286120

COVID-19 Infection Changes the Functions and Morphology of Erythrocytes: A Multidisciplinary Study
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Sales, Marcos V. S.

; Tanabe, Eloiza L. L.

; Maciel, Thamilla M. S.

; Tavares, Maria C. Leal, Juliana G. C. Pinto, Larissa S. Pires, Keyla S. N. Coelho, Jorge A. P. M. Silva, Elaine C. O. Souza, Samuel T. Fonseca, Eduardo J. S. Fragoso, Thiago S. Aquino, Thiago M. Borbely, Alexandre U. Rocha, Ueslen Santos, Josué C. C. Leite, Ana Catarina R.

Journal of the Brazilian Chemical Society

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Ago 2023, Volume 34 Nº 8 Páginas 1185 - 1196

Resumo: En | Texto: En | PDF: En

Hematological problems are associated with Coronavirus disease 2019 (COVID-19). Respiratory impairment is the higher point studied, although without experimental studies related to the oxygen transport performed by erythrocytes. Therefore, we decided to investigate if erythrocytes from COVID-19 patients have their functionality changed. The case-control study included hospitalized patients with a positive real-time polymerase chain reaction (RT-PCR) result admitted to University Hospital. Volunteers (negative RT-PCR results) were recruited as a control group. Thus, we assessed different erythrocytes parameters, oxidative stress markers, and biophysical studies using whole blood and isolated hemoglobin. We found a decrease of 51% in oxygen uptake and reduced antioxidant enzyme activity in COVID-19 patients compared to controls. Raman spectrometry showed structural changes in the hemoglobin and lipids of the erythrocytes from COVID-19 patients; thus, these results were consolidated with an increase in Young’s modulus in erythrocytes followed by morphology changes. Besides, isolated hemoglobin from COVID-19 patients has a distinct interaction profile using a ligand model compared to the control. COVID-19 leads to structural, functional, and morphological damage to human erythrocytes. Our data showed structural and molecular changes and induction of oxidative stress in erythrocytes by COVID-19, a new perspective on the contribution of erythrocytes to a respiratory commitment in COVID-19.

https://doi.org/10.21577/0103-5053.20230031

Risk of malignancy and diagnostic accuracy of fine-needle aspiration biopsy in thyroid nodules with diameters greater than 4 centimeters fineneedle fine needle
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Barcelos, Rafaela N.

; Camacho, Cléber P.

; Mamone, Maria da Conceição de O. C.

; Ikejiri, Elza S.

; Vanderlei, Felipe A. B.

; Yang, Ji H.

; Padovani, Rosália P.

; Martins, Leandro A. L.

; Biscolla, Rosa Paula M.

; Macellaro, Danielle

; Lindsey, Susan C.

; Maciel, Rui M. B.

; Martins, João Roberto M.

Archives of Endocrinology and Metabolism

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2023, Volume 67 Nº 6 elocation e000644

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: The risk of malignancy and diagnostic accuracy of fine-needle aspiration biopsy (FNAB) of thyroid nodules (TN) with diameters ≥ 3-4 cm remains controversial. However, some groups have indicated surgical treatment in these patients regardless of the FNAB results. We aimed to evaluate the diagnostic accuracy of the FNAB in systematically resected ≥4 cm TN and if the risk of malignancy is higher in these patients. Subjects and methods: We retrospectively evaluated 138 patients (142 nodules) with TN with diameters ≥4 cm who underwent thyroidectomy. Results: The FNAB results were nondiagnostic/unsatisfactory (ND/UNS) in 2.1% of the cases and benign in 51.4%. They indicated atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in 23.9% of cases, follicular neoplasia/suspicious for a follicular neoplasm (FN/SFN) in 9.2%, suspicion of malignancy (SUS) in 8.5%, and malignant in 4.9%. The histopathological analysis after thyroidectomy revealed a thyroid cancer rate of 100% in the FNABs classified as malignant, 33.3% in SUS cases, 7.7% in FN/SFN, 17.6% in AUS/FLUS, and 4.1% in benign FNABs. None of the ND/UNS FNABs were malignant. The global malignancy diagnosis was 14.8% (n = 21). However, the rate of false negatives for FNAB was low (4.1%). Conclusion: We showed that the risk of malignancy in nodules with diameters ≥4 cm was higher compared to the risk of thyroid cancer in TN in general. However, we found a low rate of false-negative cytological results; therefore, our data do not justify the orientation of routine resection for these larger nodules. Objective fineneedle fine needle (FNAB (TN 34 3 4 3- controversial However methods 13 142 (14 Results nondiagnosticunsatisfactory nondiagnostic unsatisfactory NDUNS ND UNS (ND/UNS 21 2 1 2.1 514 51 51.4% significancefollicular AUS/FLUS AUSFLUS AUS FLUS (AUS/FLUS 239 23 9 23.9 neoplasiasuspicious neoplasia suspicious FN/SFN FNSFN FN SFN (FN/SFN 92 9.2% (SUS 85 8 5 8.5% 49 4.9% 100 333 33 33.3 77 7 7.7 176 17 6 17.6 41 4.1 148 14 14.8 n 21. . 21) 4.1%. (4.1%) Conclusion general falsenegative negative therefore (1 2. 51.4 23. 9.2 8.5 4.9 10 33. 7. 17. 4. 14. (4.1% ( 51. 9. 8. (4.1 (4. (4

https://doi.org/10.20945/2359-3997000000644

Multivariate analysis of agronomic, physicochemical, and physiological characters of passion fruit hybrids cultivated at different environments
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Maciel, K. S.

; Lima, P. A. M. de

; Mengarda, L. H. G.

; de Araujo, C. P.

; Lopes, S. de O.

; Alexandre, R. S.

; Lopes, J. C.

Brazilian Journal of Biology

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2023, Volume 83 elocation e275338

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Simultaneous analysis studies of several agronomic traits in cultivated plants make it possible to identify phenotypic and genotypic differences due to environmental variations, such as altitude. Therefore, the objective was to evaluate, through multivariate analysis of agronomic, physicochemical and physiological characters, passion fruit hybrids cultivated in different environments. The hybrids used were Gigante Amarelo, Rubi do Cerrado and Sol do Cerrado, cultivated in the southern region of Espírito Santo in four municipalities/environments: Marataízes (41 m), Jerônimo Monteiro (104 m), Alegre (711 m), and Ibitirama (1016 m). The agronomic characters of the plants, the physical-chemical characteristics of the fruits and the physical, biochemical and physiological qualities of the seeds were analyzed. The Singh method was used to determine the most important differentiating characters between hybrids growing in different environments. Based on these characters, a dissimilarity matrix was generated and a principal coordinate analysis was performed. It was observed that the pulp yield was influenced by altitude. The three hybrids showed greater performance in terms of agronomic characters at altitude (41 m) than at altitude (104 m). The Sol do Cerrado hybrid showed high performance in the physical-chemical characteristics of the fruits at altitude (104 m).

Resumo Estudos de análise simultânea de diversos caracteres agronômicos em plantas cultivadas permitem identificar diferenças fenotípicas e genotípicas devido a variações ambientais, como a altitude. Diante disso, objetivou-se avaliar através da análise multivariada de caracteres agronômicos, fisico-químicos e fisiológicos, híbridos de maracujazeiros cultivados em diferentes ambientes. Os híbridos utilizados foram Gigante Amarelo, Rubi do Cerrado e Sol do Cerrado, cultivados na região sul do Espírito Santo em quatro municípios/ambientes: Marataízes (41 m), Jerônimo Monteiro (104 m), Alegre (711 m), e Ibitirama (1016 m). Foram analisados os caracteres agronômicos das plantas, as características físico-químicas dos frutos e as qualidades físicas, bioquímicas e fisiológicas das sementes. O método Singh foi usado para determinar os caracteres diferenciadores mais importantes entre híbridos crescendo em diferentes ambientes. Com base nesses caracteres, uma matriz de dissimilaridade foi gerada e uma análise de coordenadas principais foi realizada. Observou-se que o rendimento de polpa foi influenciado pela altitude. Os três híbridos apresentaram maior desempenho em termos de caracteres agronômicos na altitude (41 m) do que na altitude (104 m). O híbrido Sol do Cerrado apresentou alto desempenho nas características físico-químicas dos frutos na altitude (104 m).

https://doi.org/10.1590/1519-6984.275338

Selection of F2RC1 saladette-type dwarf tomato plant populations for fruit quality and whitefly resistance
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Oliveira, Camila S. de

; Maciel, Gabriel M.

; Siquieroli, Ana C. S.

; Gomes, Danilo A.

; Martins, Marcos P. do C.

; Finzi, Rafael R.

Revista Brasileira de Engenharia Agrícola e Ambiental

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Jan 2022, Volume 26 Nº 1 Páginas 28 - 35

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O objetivo do estudo foi selecionar populações F2RC1 de tomateiro anão do tipo saladete promissoras para o desenvolvimento de linhagens baseado em características agronômicas, qualidade de fruto e resistência a mosca branca. O delineamento experimental foi em blocos casualizados contendo 13 tratamentos (10 populações F2RC1 de tomateiro anão, genitores e híbrido comercial) com quatro repetições. Foram avaliados: peso, comprimento, diâmetro, formato, espessura da polpa, número de lóculos, teores de sólidos solúveis, β-caroteno e licopeno do fruto; comprimento do entrenó da planta; teores de acilaçúcares, número de ovos, ninfas e adultos de mosca branca nos folíolos. Os dados foram analisados por ANOVA, índices de seleção e análise multivariada. O primeiro retrocruzamento aumentou as características agronômicas das populações em relação ao genitor doador, principalmente para peso de fruto (169.1%), comprimento do fruto (26.1%) e diâmetro do fruto (16.6%). As populações UFU SDi 7, UFU SDi 9 e UFU-SDi 17 foram selecionadas por dois índices de seleção e são consideradas promissoras.

ABSTRACT This study aimed to select promising F2RC1 populations of saladette-type dwarf tomato plants for the development of breeding lines based on agronomic characteristics, fruit quality, and whitefly resistance. The experimental design was randomized blocks containing 13 treatments (10 F2RC1 populations of dwarf tomato plants, both parents, and a commercial hybrid) with four replicates. The evaluations were performed included weight, length, diameter, shape, pulp thickness, number of locules, soluble solids, β-carotene, and lycopene concentration of the fruit; plant internode length; acylsugars concentration; and number of whitefly eggs, nymphs, and adults on the leaflets. The data were analyzed using ANOVA, selection indices, and multivariate analysis. The first backcross increased the agronomic characteristics of the populations in relation to the donor parent, especially for fruit weight (169.1%), fruit length (26.1%), and fruit diameter (16.6%). The UFU SDi 7, UFU SDi 9, and UFU-SDi 17 populations were selected using two selection indices and were therefore considered promising.

https://doi.org/10.1590/1807-1929/agriambi.v26n1p28-35 42 downloads

Botanical sources and heavy metals contents of honey produced by Apis mellifera in an ecotone region of the state of Bahia, Brazil
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SILVEIRA-JÚNIOR, CRISTIANO EDUARDO A.

; LOPES, BIANCA A.

; SILVA, TÂNIA MARIA S.

; GOMES, AYALA NARA P.

; SILVA, GIRLIANE REGINA DA

; ARRUDA, RAFAEL S. DE

; MACIEL, EDSON A.

; SANTOS, FRANCISCO A.R. DOS

Anais da Academia Brasileira de Ciências

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2022, Volume 94 Supl. 4 elocation e20211551

Resumo: En | Texto: En | PDF: En

Abstract The present study investigated by palynological and chemical analysis (Flame Atomic Absortion Spectrometry) about the botanical origin and the heavy metals content (arsenic, cadmium, chromium, lead and mercury) of monthly honey samples of Apis mellifera L. over two years. The pollen types Apiaceae, Mimosa caesalpiniifolia, M. tenuiflora and Myrcia indicated the main floristic sources used by bees. M. tenuiflora was the most frequent of the pollen types, and because it predominates in different months in each year, which may indicate more than one species of the genus being foraged by the beehive. The climatic influence (rainfall and temperature) on the pollen diversity was investigated and was not statistically supported. The chemical analysis showed that the heavy metal content of the samples were below their respective limits of quantification, and, therefore, the samples can be considered safe for human consumption.

https://doi.org/10.1590/0001-3765202220211551

10.

Differences in Wildlife Roadkill Related to Landscape Fragmentation in Central Brazil
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FRAGA, LEONARDO P.

; MACIEL, SAMARA

; ZIMBRES, BÁRBARA DE Q.C.

; CARVALHO, PAULLA J. DE

; BRANDÃO, REUBER A.

; ROCHA, CLARISSE R.

Anais da Academia Brasileira de Ciências

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2022, Volume 94 elocation e20220041

Resumo: En | Texto: En | PDF: En

Abstract The interaction between animal movement and roads is pervasive, but little is known of the effects of the land-use patterns in roadside landscapes on roadkill events. Here, we compared wildlife roadkill along two road stretches that cross landscapes with different land-use patterns, including the presence of protected areas in Central Brazil. Sampling was conducted in 2017 and 2018 in two seasons (dry and rainy). We expected roadkill events to be more frequent bordering the protected area. Roadkill occurred more frequently in the rainy season in the unprotected landscape. Birds were most frequently recorded in the unprotected (44%, n = 76) than in the protected landscape (37%, n = 48). The least recorded group in the unprotected landscape was Squamata (11%, n = 18), while mammals were less detected in the protected landscape (14%, n = 18). Classes ‘agriculture’ and ‘savanna’ were related to amphibian roadkill numbers. For Squamata, we observed the effect of the presence of forests in the protected landscape. Bird roadkill was affected by protection level, while the presence of pasture and the level of protection explained mammal roadkill. Differences in roadkill patterns reinforce the need for long-term management of this source of mortality for the Cerrado fauna.

https://doi.org/10.1590/0001-3765202220220041

11.

Use of non-invasive stimulation in movement disorders: a critical review
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Godeiro, Clecio

; França, Carina

; Carra, Rafael Bernhart

; Saba, Felipe

; Saba, Roberta

; Maia, Débora

; Brandão, Pedro

; Allam, Nasser

; Rieder, Carlos R. M.

; Freitas, Fernando Cini

; Capato, Tamine

; Spitz, Mariana

; Faria, Danilo Donizete de

; Cordellini, Marcela

; Veiga, Beatriz A. A. G.

; Rocha, Maria Sheila G.

; Maciel, Ricardo

; Melo, Lucio B. De

; Möller, Patricia D. S.

; R. R. Júnior, Magno

; Fornari, Luís H. T.

; Mantese, Carlos E.

; Barbosa, Egberto Reis

; Munhoz, Renato P.

; Coletta, Marcus Vinicius Della

; Cury, Rubens Gisbert

Arquivos de Neuro-Psiquiatria

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Jul 2021, Volume 79 Nº 7 Páginas 630 - 646

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução: A estimulação não-invasiva tem sido amplamente utilizada nos últimos 30 anos no estudo e no tratamento de um grande número de doenças neurológicas, incluindo distúrbios do movimento. Objetivos: Nesta revisão crítica, discutimos o embasamento científico do uso da estimulação não-invasiva em distúrbios do movimento e as evidências científicas dos principais ensaios clínicos realizados. Métodos: Um grupo de especialistas realizou uma revisão crítica abrangente da literatura a fim de analisar as principais aplicações da estimulação magnética transcraniana (EMT) e da estimulação transcraniana por corrente contínua (ETCC) em distúrbios do movimento. As classes de evidência e de recomendação foram descritas para cada doença. Resultados: Apesar da grande variabilidade da metodologia e baixo efeito clínico, a EMT é provavelmente eficaz para o tratamento dos sintomas motores e da depressão na doença de Parkinson. A eficácia em outros distúrbios do movimento ainda é incerta. A EMT é possivelmente eficaz para o tratamento da distonia focal da mão, do tremor essencial e da ataxia cerebelar. No entanto, é provavelmente ineficaz na redução dos tiques na síndrome de Tourette. Finalmente, a ETCC é provavelmente eficaz na melhora da marcha na doença de Parkinson. Conclusões: As evidências até o momento sugerem que a estimulação não-invasiva pode ser benéfica para o alívio de alguns sintomas em determinados distúrbios do movimento como a doença de Parkinson, o tremor essencial, a distonia e a ataxia. Os protocolos de aplicação e paradigmas de estimulação ainda precisam ser investigados em ensaios clínicos maiores, assim como os seus efeitos a longo prazo.

Abstract Background: Noninvasive stimulation has been widely used in the past 30 years to study and treat a large number of neurological diseases, including movement disorders. Objective: In this critical review, we illustrate the rationale for use of these techniques in movement disorders and summarize the best medical evidence based on the main clinical trials performed to date. Methods: A nationally representative group of experts performed a comprehensive review of the literature in order to analyze the key clinical decision-making factors driving transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) in movement disorders. Classes of evidence and recommendations were described for each disease. Results: Despite unavoidable heterogeneities and low effect size, TMS is likely to be effective for treating motor symptoms and depression in Parkinson’s disease (PD). The efficacy in other movement disorders is unclear. TMS is possibly effective for focal hand dystonia, essential tremor and cerebellar ataxia. Additionally, it is likely to be ineffective in reducing tics in Tourette syndrome. Lastly, tDCS is likely to be effective in improving gait in PD. Conclusions: There is encouraging evidence for the use of noninvasive stimulation on a subset of symptoms in selected movement disorders, although the means to optimize protocols for improving positive outcomes in routine clinical practice remain undetermined. Similarly, the best stimulation paradigms and responder profile need to be investigated in large clinical trials with established therapeutic and assessment paradigms that could also allow genuine long-term benefits to be determined.

https://doi.org/10.1590/0004-282x-anp-2020-0381 427 downloads

12.

Why pediatricians need to know the disorders of sex development: experience of 709 cases in a specialized service,
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Beck, Mayra de Souza El

; Germano, Carlos W.

; Barros, Beatriz A.

; Andrade, Juliana G.R.

; Guaragna-Filho, Guilherme

; Paula, Georgette B.

; Miranda, Márcio L.

; Guaragna, Mara S.

; Fabbri-Scallet, Helena

; Mazzola, Tais N.

; Viguetti-Campos, Nilma L.

; Vieira, Társis A.P.

; Lemos-Marini, Sofia H.V.

; Marques-de-Faria, Antonia P.

; Silva, Roberto B. Paiva e

; Mello, Maricilda P.

; Maciel-Guerra, Andréa T.

; Guerra-Júnior, Gil

Jornal de Pediatria

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Dez 2020, Volume 96 Nº 5 Páginas 607 - 613

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Avaliar em uma amostra de pacientes com distúrbios da diferenciação do sexo (DDS), dados relacionados à idade, ao encaminhamento e sua correlação com as queixas iniciais, ao sexo ao encaminhamento e ao sexo final e diagnóstico etiológico. Métodos: Revisão retrospectiva da idade por ocasião da primeira consulta e motivo dela, sexo social inicial e após definição do diagnóstico, cariótipo e diagnóstico etiológico de todos os casos atendidos em um ambulatório especializado em DDS entre 1989 e 2016. Foram excluídos casos que não compreendiam DDS e diagnósticos de DDS que não cursam comumente com ambiguidade genital, não necessitam de acompanhamento especializado. Resultados: Dos 1.793 casos atendidos, 1.139 foram diagnosticados com algum DDS. Excluíram-se 430 (272 síndrome de Turner, 66 síndrome de Klinefelter e 92 disgenesia gonadal pura), totalizando 709. Desses, 82,9% foram encaminhados por ambiguidade genital, somente um quarto ainda no primeiro mês de vida e 6,6% por atraso puberal, a maioria com 10 anos ou mais; 68,6% tiveram diagnóstico de DDS XY; 22,4% DDS XX e 9% de anomalias dos cromossomos sexuais. Conclusões: Este estudo apresenta a maior casuística na literatura de pacientes com DDS atendidos em um único serviço. O momento de encaminhamento da maioria dos pacientes com ambiguidade genital foi aquém do ideal e casos mais leves de ambiguidade e muitos com manifestações puberais foram encaminhados ainda mais tardiamente. Os resultados reforçam a importância do ensino continuado a profissionais que terão o primeiro contato com esses pacientes, principalmente pediatras e neonatologistas.

Abstract Objective: To evaluate, in a sample of patients with disorders of sex development (DSD), data related to the age at referral and their correlation with the initial complaints, gender at referral, defined gender after diagnosis and etiological diagnosis. Methods: Retrospective review of the age at the first consultation and the reason for it, initial social gender and gender after the diagnosis, karyotype and etiological diagnosis of all cases treated at a DSD outpatient clinic between 1989 and 2016. Cases that did not involve DSD and DSD diagnoses that do not usually involve ambiguous genitalia, thus not requiring specialized monitoring, were excluded. Results: Of the 1793 treated cases, 1139 were diagnosed with some type of DSD. This study excluded 430 cases (272 with Turner's syndrome, 66 with Klinefelter syndrome, and 92 with pure gonadal dysgenesis), thus a total 709 individuals were included. Of these, 82.9% were referred due to ambiguous genitalia; only one-quarter were still in the first month of life, and 6.6% were referred due to pubertal delay, with most of them aged 10 years or older. Of these patients, 68.6% had a diagnosis of XY DSD, 22.4% of XX DSD, and 9% of sex chromosome abnormalities. Conclusions: This study presents the largest series in the literature of patients with DSD treated in a single center. The time of referral of the majority of patients with ambiguous genitalia fell short of the ideal, and milder cases of ambiguous genitalia and many with pubertal manifestations were referred even later. The results reinforce the importance of continuing education for professionals who will have the first contact with these patients, mainly pediatricians and neonatologists.

https://doi.org/10.1016/j.jped.2019.04.007 650 downloads

13.

Characterization of the Dielectric Properties of the Tommy Atkins Mango
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Silva Júnior, Paulo F.

; Santana, Ewaldo E. C.

; Pinto, Mauro S. Silva

; Andrade, Everson P.

; Carvalho, Joabson N.

; Freire, Raimundo C. S.

; Oliveira, Maciel A.

; Oliveira, Elder E. Carneiro de

Journal of Microwaves, Optoelectronics and Electromagnetic Applications

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Mar 2020, Volume 19 Nº 1 Páginas 86 - 93

Resumo: En | Texto: En | PDF: En

Abstract This paper presents the characterization of dielectric properties (dielectric permittivity and dielectric loss factor) of Tommy Atkins mango (Mangifera indica L), a fruit produced in several regions of Brazil, of great economic importance. The fruits were characterized according to their maturation index, by probe method, and identified by the yellowish tone in their bark. The results allowed correlating the dielectric characteristics of the fruit with the physicochemical transformations that occurred in the maturation process of the mango Tommy. It was also verified a greater variation in the frequencies below 1 GHz, with the maturation indicated by the dielectric signature on the fifth day after the harvest. From these results, we can observe the use of electromagnetic materials and techniques in the solution and optimization of processes in agriculture can improve the quality of products consumed or suggesting best practices to the productive sector.

https://doi.org/10.1590/2179-10742020v19i11868 674 downloads

14.

Soybean yield in the Matopiba region under climate changes
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Silva, Vicente de P. R. da

; Silva, Roberta A. e

; Maciel, Girlene F.

; Souza, Enio P. de

; Braga, Célia C.

; Holanda, Romildo M. de

Revista Brasileira de Engenharia Agrícola e Ambiental

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Jan 2020, Volume 24 Nº 1 Páginas 8 - 14

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO As condições climáticas durante o ciclo da cultura são os principais fatores responsáveis pela produção final de qualquer cultivo. Este estudo teve o objetivo de avaliar as condições atuais e os efeitos dos cenários de mudanças climáticas sobre a produtividade da soja cultivada na região de Matopiba, localizada entre os Estados do Tocantins, Sul e Nordeste do Maranhão, Sul do Piauí e Oeste da Bahia. O modelo AquaCrop, versão 5.0 da FAO foi calibrado com dados do ano de 2014 e validado com os de 2016 em Palmas, TO, usando parâmetros de clima, solo, manejo da cultura coletados em duas campanhas experimentais realizadas entre os meses de junho e outubro nos anos de 2014 e 2016. O desempenho do modelo foi avaliado utilizando os indicadores estatísticos: erro de previsão (EP), coeficiente de determinação (R2), raiz quadrada do erro médio normalizado (RMSEN), coeficiente de eficiência do modelo Nash-Sutcliffe (EF) e o índice de concordância de Willmott (d). Verificou-se que o modelo AquaCrop subestima a produtividade de grãos de soja, na condição de déficit hídrico severo durante todo o ciclo do cultivo. O aumento da concentração de CO2 e da temperatura, projetada pelos modelos climáticos HadGEM2-ES e MIROC5 sob o cenário de estabilização (RCP 4.5) e o cenário de progressão RCP 8.5, contribuem para o aumento da produtividade de soja até o final deste século.

ABSTRACT The climatic conditions along the cycle are the main factors responsible for the final production of any crop. This study aimed to evaluate the current conditions and the effects of climate change scenarios on the yield of soybean grown in the Matopiba region, located between the states of Tocantins, south and northeast of Maranhão, south of Piauí and west of Bahia, Brazil. The AquaCrop model of FAO, version 5.0, was calibrated with data of 2014 and validated with those of 2016, using climate, soil and crop management parameters collected in two experimental campaigns conducted between June and October in 2014 and 2016 in Palmas, TO, Brazil. The performance of the model was evaluated using the following statistical indicators: prediction error (PE), coefficient of determination (R2), normalized root mean square error (NRMSE), Nash-Sutcliffe model efficiency coefficient (EF) and Willmott’s index of agreement (d). It was verified that the AquaCrop model underestimates soybean grain yield under severe water stress conditions throughout the growing cycle. The increase in CO2 concentration and in the air temperature, projected by the climate models HadGEM2-ES and MIROC5 under the scenario of stabilization (RCP 4.5) and the scenario of progression (RCP 8.5), have contributed to the increase in soybean yield by the end of this century.

https://doi.org/10.1590/1807-1929/agriambi.v24n1p8-14 1506 downloads

15.

Essa eu vou postar: Explorando as relações entre narcisismo, uso do Instagram e a moderação da autoestima
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Monteiro, Renan P.

; Monteiro, Tatiana Medeiros Costa

; Maciel, Vitória Crancio

; Masotti, Fábio Nasser de A.

; Freitas, Igor Matheus de Souza

; Candido, Juarid

Psicología, Conocimiento y Sociedad

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2020, Volume 10 Nº 2 Páginas 38 - 50

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

Resumen: El narcisismo involucra características como el exhibicionismo, grandiosidad y necesidad constante de ser admirado. Dichas características apuntan el papel fundamental que este rasgo de personalidad puede tener para explicar el uso del Instagram. Esta red social parece ser un escenario propicio para que los narcisistas puedan autopromoverse y mantener su autoconcepto grandioso y irrealístico, buscando feedback positivo por medio de curtidas, visualizaciones y comentarios. En esta dirección, este estudio tiene por objetivo analizar el rol predictor del narcisismo con relación al uso del Instagram, evaluando el rol moderador de la autoestima. 207 personas usuarias de Instagram participaron del estudio, teniendo en cuenta que narcisistas pasan más tiempo en Instagram, publican más fotos y stories, atribuyendo mucha importancia a recibir feedbacks. Además, se observó que la importancia atribuida a recibir feedbacks fue más elevada entre los narcisistas con baja autoestima, siendo que recibir curtidas y visualizaciones pueden ser una forma de compensación para los bajos niveles en esta variable. Por lo tanto, se observa que el uso del Instagram puede ser explicado por medio del narcisismo, pudiendo haber interacciones con la autoestima, dando importantes claves para entender el uso problemático de esta red social.

Abstract: Narcissism involves characteristics such as exhibitionism, grandiosity and a constant need to be admired. Such characteristics highlight the role that this personality trait may have in the use of Instagram. This social network seems to be a propitious setting for narcissists to self-promote and maintain their grandiose and unrealistic self-concept by seeking positive feedback through number of likes, views, and comments. Thus, the present study aims to analyze the predictive role of narcissism in Instagram use, testing the moderating role of self-esteem. Participants were 207 users of this social network, whereby it was identified that narcissists tend to spend more time on Instagram, post more pictures and stories, giving much importance to receiving feedback (likes and views). Moreover, it was verified that the importance attributed to receiving such feedback was stronger among the narcissists with low self-esteem, such that gathering likes and views can be a way of compensating for low self-esteem. Therefore, it was observed that the use of Instagram can be explained by narcissism, and there may be interactions with self-esteem, which gives important insights to the understanding of the problematic use of this social network.

Resumo: O narcisismo envolve características como exibicionismo, grandiosidade e necessidade constante de ser admirado. Tais características apontam o papel fundamental que este traço de personalidade pode ter para explicar o uso do Instagram. Esta rede social parece ser um cenário propício para que os narcisistas possam se autopromover e manterem seu autoconceito grandioso e irrealístico, buscando feedback positivo por meio de curtidas, visualizações e comentários. Nesta direção, o presente estudo objetiva analisar o papel preditor do narcisismo em relação ao uso do Instagram, testando o papel moderador da autoestima. Participaram 207 usuários desta rede social, sendo identificado que narcisistas tendem a passar mais tempo no Instagram, postam mais fotos e stories, atribuindo muita importância a receber feedback (curtidas e visualizações). Ademais, verificou-se que a importância atribuída a receber feedbacks foi mais forte entre os narcisistas que possuem baixa autoestima, sendo que receber curtidas e visualizações pode ser uma forma de compensação para os baixos níveis nesta variável. Portanto, observa-se que o uso do Instagram pode ser explicado por meio do narcisismo, podendo haver interações com a autoestima, dando importantes insights para se entender o uso problemático desta rede social.

https://doi.org/10.26864/pcs.v10.n2.3 2518 downloads

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