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ABSTRACT Purpose: To evaluate the peritoneal histopathological changes and culture after the use of intravenous meropenem and intra-abdominal inoculation of 10% aqueous extract of anacardiaceae, in elderly rat model after autogenous fecal peritonitis induced. Methods: Thirty 18-month-old Wistar rats received induction of autogenous fecal peritonitis and then were stratified into two groups: study I, treated with meropenem (40 mg/kg); and study II, treated with meropenem (40 mg/kg) and intraperitoneal 10% aqueous extract of anacardiaceae. Animals were monitored for 15 days until euthanasia. Peritoneal fragments were collected for histopathological and culture. The study was approved by Ethics Committee. Results: None study-II animals died, while in study I, one died before euthanasia. In study II, 20% of the animals showed histopathological changes, none positive peritoneal culture, but one blood culture was positive (10%). In study I, 50% of the animals presented histopathological changes, 40% positive peritoneal cultures, and 50% positive blood cultures. All results when evaluated in the morbidity score showed better outcome for study-II group (p = 0,175). Conclusion: The use of meropenem associated with intraperitoneal 10% aqueous anacardiaceae extract after induction of autogenous fecal peritonitis in elderly rats showed better outcome in the set of histopathological changes, negative peritoneal and blood cultures, when compared with the use of meropenem isolated. Purpose intraabdominal intra abdominal 10 induced Methods 18monthold monthold 18 month old groups I 40 (4 mg/kg mgkg mg kg II 1 euthanasia Committee Results studyII 20 10%. . (10%) 50 cultures p 0,175. 0175 0,175 0 175 0,175) Conclusion isolated 4 ( 2 (10% 5 017 0,17 17 (10 01 0,1 (1 0,

https://doi.org/10.1590/acb400125

Carcinoma Neuroendócrino de Pequenas Células da Laringe: Um Caso Clínico e Revisão da Literatura
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Alves, Alice

; Fernandes, Catarina

; Machado-Neves, Raquel

; Penêda, José Ferreira

; Vilaça, Marta

; Elzen, Catarina van

; Martins, Filipa

; Lopes, Gustavo

; Oliveira, Nuno

; Casalta-Lopes, João

; Cunha-Cabral, Diogo da

; Vendeira, Lurdes

Revista Portuguesa Otorrinolaringologia e Cirurgia de Cabeça e Pescoço

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Set 2024, Volume 62 Nº 3 Páginas 297 - 303

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Os Carcinomas neuroendócrinos (CNE) são tumores raros e heterogéneos em Cabeça e Pescoço (CP) especialmente na laringe, representando menos de 1% dos tumores primários. São classificados em diferentes graus de acordo com a diferenciação celular. O tratamento é multidisciplinar e inclui quimioterapia, cirurgia e radioterapia. Descreve-se o caso clínico de uma paciente de 73 anos com disfonia progressiva e com lesão laríngea. A biópsia histológica da lesão confirmou carcinoma neuroendócrino de pequenas células (CNEPC). A doente foi estadiada como um T3N0M0 e foi submetida a quimioterapia e radioterapia concomitantes. Devido a uma obstrução aguda da via aérea, passou por uma cirurgia a laser de CO2. Após o tratamento com radioterapia (com dose total de 70Gy) e quimioterapia com carboplatino e etoposídeo, a paciente apresentava-se com bom estado geral e sem queixas relacionadas com tratamento. O tratamento do CNEPC geralmente inclui uma abordagem multidisciplinar, no entanto, a taxa de recorrência é elevada, destacando a necessidade de um acompanhamento rigoroso para atuação tão precoce quanto possível, assim como follow-up a longo prazo para avaliar a eficácia do tratamento e a sobrevida dos pacientes. Em conclusão, este caso representa uma patologia rara, diagnosticado num estadio precoce em que foi possível realizar terapêutica com intuito radical graças a uma abordagem multidisciplinar, sem intercorrências major, e até ao momento sem evidência de recidiva.

Abstract Neuroendocrine carcinomas (NEC) are rare and heterogeneous tumours in the Head and Neck (HN), especially in the larynx, representing less than 1% of primary tumours. They are classified into different grades according to cellular differentiation. Treatment is multidisciplinary and includes chemotherapy, surgery, and radiotherapy. We describe the case of a 73-year-old patient with progressive dysphonia and laryngeal lesion. Histological biopsy of the lesion confirmed small cell neuroendocrine carcinoma (SNEC). The patient was staged as T3N0M0 and underwent concurrent chemotherapy and radiotherapy. Due to acute airway obstruction, she underwent CO2 laser surgery. Following treatment with radiotherapy (total dose of 70Gy) and chemotherapy with carboplatin and etoposide, the patient was in good overall condition with no treatment-related complaints. Treatment of SNEC generally involves a multidisciplinary approach; however, the recurrence rate is high, highlighting the need for rigorous monitoring for early intervention, as well as long-term follow-up to assess treatment efficacy and patient survival. In conclusion, this case represents a rare entity, diagnosed in an early stage in which a radical treatment was possible thanks to a multidisciplinar approach, with no major intercurrence, and with no evidence of relapse until the present moment.

https://doi.org/10.34631/sporl.2166

New organic substrates for seedling production in the transition zone between the Amazon-Cerrado biomes AmazonCerrado Amazon Cerrado
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Conceição, Aldenice O.

; Andrade, Hosana A. F. de

; Rego, Carlos A. R. de M.

; Morais, Pedro A. de O.

; Pereira, Ramón Y. F.

; Sousa, Andreza M. de

; Santos, Gustavo A. de A.

; Moraes, Lídia F.

; Machado, Nítalo A. F.

; Silva-Matos, Raissa R. S. da

Revista Brasileira de Engenharia Agrícola e Ambiental

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Jun 2024, Volume 28 Nº 6 elocation e279358

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO No ecótono Amazônia-Cerrado, o aumento dos custos com insumos não orgânicos e transporte torna os substratos mais caros, estimulando o uso da biomassa decomposta do caule da palmeira nativa para a produção de mudas. O estudo foi realizado com o objetivo de avaliar as características físico-químicas da biomassa decomposta de babaçu (BDB), carnaúba (BDC) e buriti (BBU) comparado ao substrato comercial (SC) via estatística multivariada. O estudo utilizou um banco de dados composto por 90 substratos, obtidos em fazendas do Maranhão, Brasil. Essas amostras passaram por caracterização físico-química seguindo o protocolo brasileiro para substratos de mudas. Os substratos à base de BDB e BDC apresentam pH e teores de nutrientes em valores aceitáveis, além de menor acidez potencial e elevada saturação por bases em comparação aos substratos BBU e SC. A análise de componentes principais e agrupamento hierárquico revelou similaridades entre BDB, BDC e SC. A biomassa decomposta dos caules das palmeiras babaçu e carnaúba é recomendada como substrato alternativo para produtores de mudas no ecótono Amazônia-Cerrado. AmazôniaCerrado, AmazôniaCerrado Amazônia Cerrado, Cerrado Amazônia-Cerrado caros físicoquímicas físico químicas , (BDB) (BDC (BBU SC (SC multivariada 9 Maranhão Brasil físicoquímica química aceitáveis AmazôniaCerrado. Cerrado. (BDB

ABSTRACT In the Amazon-Cerrado ecotone, increased costs from non-organic inputs and transportation render substrates more expensive, prompting the use of decomposed biomass from native palm stem for seedlig production. The study was carried out with the objective of evaluate the physicochemical characteristics of the decomposed biomass of babassu palms (BDB), carnauba (BDC), and buriti (BBU) compared to the commercial substrate (SC) via multivariate analysis. This study employed a database comprising 90 substrates, obtained from Maranhão, Brazil farms. These samples underwent physicochemical characterization following the Brazilian protocol for seedling substrates. The substrates based on BDB and BDC have pH and nutrient contents at acceptable values, in addition to lower potential acidity and high base saturation compared to BBU and SC substrates. Principal component analysis and hierarchical clustering revealed similarities between BDB, BDC and SC. Biomass decomposed from the stems of babassu and carnauba palms is recommended as an alternative substrate for seedling producers in the in the Amazon-Cerrado ecotone. AmazonCerrado Amazon Cerrado ecotone nonorganic non organic expensive production , (BDB) BDC, (BDC) (BBU (SC 9 Maranhão farms values (BDB (BDC

https://doi.org/10.1590/1807-1929/agriambi.v28n6e279358

Esophageal and gastric pythiosis in a dog
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Silva, Emanoelly Machado Sousa da

; Martins, Kamila Peruchi Fernandes

; Pereira, Asheley Henrique Barbosa

; Gris, Anderson Hentz

; Maruyama, Fernanda Harumi

; Nakazato, Luciano

; Colodel, Edson Moleta

; Oliveira, Luiz Gustavo Schneider de

; Boabaid, Fabiana Marques

Ciência Rural

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2024, Volume 54 Nº 6 elocation e20230272

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: A Pitiose é uma doença causada por oomicetos aquáticos do gênero Pythium. Em cães o curso típico da doença envolve o trato gastrointestinal, caracterizado por espessamento transmural do estômago ou intestinos. No entanto, a infecção por Pythium spp. raramente foi reconhecida como causa de esofagite em caninos. Assim, o presente trabalho tem como objetivo relatar um caso de pitiose esofágica e gástrica em um canino Pit Bull fêmea de oito meses de idade. O cão foi recebido no hospital com histórico de regurgitação e dispneia durante dois meses. Foi relatado que o animal era de um domicílio de área urbana e não possuía histórico pregresso de enfermidades. No exame clínico contatou-se ainda crepitações à ausculta pulmonar. Foi instituído tratamento de suporte e antibioticoterapia, porém após 22 dias de internação, o cão evoluiu para o óbito. Na necropsia, as paredes do segmento distal do esôfago e o cárdia e parte do fundo do estômago estavam expandidos por uma massa anular intramural focalmente extensiva e irregular. Além disso, havia uma fístula esofágica transmural. À histologia, as paredes do esôfago e do estômago apresentavam-se difusamente expandidas por áreas multifocais extensas de necrose, associadas a infiltrado piogranulomatoso, abundante proliferação de fibroblastos imaturos, neovascularização e contendo múltiplas imagens negativas de hifas realçadas pela impregnação por prata (Grocott). Além disso, tanto a imuno-histoquímica como PCR para P. insidiosum foram positivas em amostras de esôfago embebidas em parafina. RESUMO gastrointestinal intestinos entanto spp caninos Assim idade enfermidades contatouse contatou se pulmonar antibioticoterapia 2 internação óbito necropsia irregular disso histologia apresentavamse apresentavam necrose piogranulomatoso imaturos Grocott. Grocott . (Grocott) imunohistoquímica imuno histoquímica P parafina (Grocott

ABSTRACT: Pythiosis is the disease caused by aquatic oomycetes of the genus Pythium. In dogs the typical course of the disease involves the gastrointestinal tract, characterized by transmural thickening of the stomach or intestines. However, infection by Pythium spp. has only rarely been recognized as a cause of esophagitis in dogs. Thus, the present reports a case of esophageal and gastric pythiosis in an eight-month-old female pit bull dog. The dog was attended at the hospital after two months presenting regurgitation and dyspnea. It was reported that the dog lived in an urban area and had no previous sanitary issues. At clinical examination it was noted that the dog presented crackling sounds at pulmonary auscultation. A support therapy accompanied by antibiotics has been employed; however, 22 days after hospitalization the clinical condition worsened, and the dog died. At necropsy, the wall of the distal segment of the esophagus and the cardia and part of the fundus of the stomach were expanded by a focal extensive irregular intramural annular mass. Additionally, there was a transmural esophageal fistula. At histology, the walls of the esophagus and stomach were extensively expanded by multifocal extensive areas of necrosis, associated with a pyogranulomatous infiltrate and abundant granulation tissue containing multiple negative images of hyphae that were highlighted by silver impregnation (Grocott). Furthermore, immunohistochemistry and PCR for P. insidiosum were both positive in samples of paraffin-embedded esophageal tissue. ABSTRACT tract intestines However spp Thus eightmonthold eight month old dyspnea issues auscultation employed however 2 worsened died necropsy mass Additionally fistula histology necrosis Grocott. Grocott . (Grocott) Furthermore P paraffinembedded paraffin embedded (Grocott

https://doi.org/10.1590/0103-8478cr20230272

Characteristics of ST-Elevation Myocardial Infarction during the SARS-CoV-2 Outbreak STElevation ST Elevation SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- SARS-CoV
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Machado, Guilherme Pinheiro

; Araujo, Gustavo Neves de

; Beltrame, Rafael

; Theobald, André Luiz

; Niches, Matheus de Souza

; Fracasso, Julia Fagundes

; Milan, Victoria

; Custodio, Julia Luchese

; Cardoso, Camila Porto

; Tietz, Pedro Henrique Torres

; Reichert, Giulia Bonatto

; Schmidt, Marcia Moura

; Quadros, Alexandre Schaan de

; Wainstein, Marco Vugman

International Journal of Cardiovascular Sciences

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2024, Volume 37 elocation e20220203

Resumo: En | Texto: En | PDF: En

Abstract Background The SARS-CoV-2 outbreak has led to radical transformation in social, economic, and healthcare systems. This may lead to profound indirect consequences on clinical presentation and management of patients with ST-segment–elevation myocardial infarction. Objectives The objective of this study was to describe the characteristics, management, and outcomes of patients admitted with acute myocardial infarction with ST-segment elevation (STEMI), in two tertiary reference hospitals during the SARS-CoV-2 outbreak and compare them with patients admitted in the previous year. Methods We analyzed data from a multicenter STEMI registry from reference centers in the South Region of Brazil from March 2019 to May 2021. The beginning of the COVID-19 outbreak was considered to be March 2020 and compared to the same period in 2019. Only patients with STEMI submitted to primary percutaneous coronary intervention (PCI) were included in the analysis. Mortality rates were compared with chi-square test. All hypothesis tests had a two-sided significance level of 5%. Results A total of 1169 patients admitted with STEMI were enrolled in our registry, 635 of whom were admitted during the pandemic period. The mean age of our sample was 61.6 (± 12.4) years, and 66.7% of patients were male. Pain-to-door time and door-to-balloon time were longer during the pandemic period. However, there was no difference in mortality rates or major adverse cardiovascular outcomes (MACE). Conclusions We observed a stable incidence of STEMI cases in our registry during the SARS-CoV-2 outbreak with higher pain-to-door time and door-to-balloon time, without any influence on mortality rates however. SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- social economic systems STsegment–elevation STsegmentelevation ST segment–elevation segment characteristics STsegment STEMI, , (STEMI) year 201 2021 COVID19 COVID 19 COVID-1 202 PCI (PCI analysis chisquare chi square test twosided sided 5 5% 116 63 616 61 6 61. ± ( 12.4 124 12 4 years 667 66 7 66.7 male Paintodoor Pain door doortoballoon balloon However MACE. MACE . (MACE) paintodoor pain however SARS-CoV segmentelevation (STEMI 20 COVID1 1 COVID- 11 12. 66. (MACE

https://doi.org/10.36660/ijcs.20220203

Acidic and Basic Functionalized Biochar from Licuri Nutshell for Methylene Blue Removal: A More Sustainable Solution for Wastewater Treatment Removal
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Bitencourt, Gustavo F.

; Machado, Letícia F. L.

; Peixoto, Bruno S.

; Castro, Laís F. de

; Veloso, Márcia Cristina C.

; Romeiro, Gilberto A.

; Lima, Thiago M.

Journal of the Brazilian Chemical Society

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2024, Volume 35 Nº 5 elocation e-20230182

Resumo: En | Texto: En | PDF: En

The right to clean water is one of the Sustainable Development Goals from the United Nations Agenda 2030. Industrial activity produces several tons of wastewater daily contaminated with dyes that must be treated. In this sense, the adsorption employing carbon-based materials as adsorbents is one of the most used and efficient processes. In this study, we developed a more sustainable biochar derived from a licuri nutshell (LN), a typical Brazilian lignocellulosic residue, for methylene blue (MB) removal. The chemical treatment of this biochar with sulfuric acid and sodium hydroxide created a functional structure with acid and basic sites. The licuri nutshell modified biochar (LNMB) presented a maximum adsorption capacity of MB of 826.45 mg g-1, while the non-modified biochar and the commercial activated carbon presented only 5.27 and 142.86 mg g-1, respectively. The recyclability of the adsorbents was evaluated, and there was a loss of efficiency in each cycle for every material. However, it is remarkable that LNMB presented in only one adsorption cycle almost six times more MB removal than the commercial material, thus proving its promising feature as a greener adsorbent derived from lignocellulosic waste. 2030 treated sense carbonbased based processes study LN, LN , (LN) residue (MB sites (LNMB 82645 826 45 826.4 g1, g1 g 1, 1 g-1 nonmodified non 527 5 27 5.2 14286 142 86 142.8 respectively evaluated material However waste 203 (LN 8264 82 4 826. g- 52 2 5. 1428 14 8 142. 20

https://doi.org/10.21577/0103-5053.20230182

Prospective, randomized, controlled trial assessing the effects of a driving pressure–limiting strategy for patients with acute respiratory distress syndrome due to community-acquired pneumonia (STAMINA trial): protocol and statistical analysis plan Prospective randomized pressurelimiting pressure limiting communityacquired community acquired STAMINA trial)
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Maia, Israel Silva

; Medrado Jr, Fernando Azevedo

; Tramujas, Lucas

; Tomazini, Bruno Martins

; Oliveira, Júlia Souza

; Sady, Erica Regina Ribeiro

; Barbante, Letícia Galvão

; Nicola, Marina Lazzari

; Gurgel, Rodrigo Magalhães

; Damiani, Lucas Petri

; Negrelli, Karina Leal

; Miranda, Tamiris Abait

; Santucci, Eliana

; Valeis, Nanci

; Laranjeira, Ligia Nasi

; Westphal, Glauco Adrieno

; Fernandes, Ruthy Perotto

; Zandonai, Cássio Luis

; Pincelli, Mariangela Pimentel

; Figueiredo, Rodrigo Cruvinel

; Bustamante, Cíntia Loss Sartori

; Norbin, Luiz Fernando

; Boschi, Emerson

; Lessa, Rafael

; Romano, Marcelo Pereira

; Miura, Mieko Cláudia

; Alencar Filho, Meton Soares de

; Dantas, Vicente Cés de Souza

; Barreto, Priscilla Alves

; Hernandes, Mauro Esteves

; Grion, Cintia Magalhães Carvalho

; Laranjeira, Alexandre Sanches

; Mezzaroba, Ana Luiza

; Bahl, Marina

; Starke, Ana Carolina

; Biondi, Rodrigo Santos

; Dal-Pizzol, Felipe

; Caser, Eliana Bernadete

; Thompson, Marlus Muri

; Padial, Andrea Allegrini

; Veiga, Viviane Cordeiro

; Leite, Rodrigo Thot

; Araújo, Gustavo

; Guimarães, Mário

; Martins, Priscilla de Aquino

; Lacerda, Fábio Holanda

; Hoffmann Filho, Conrado Roberto

; Melro, Livia

; Pacheco, Eduardo

; Ospina-Táscon, Gustavo Adolfo

; Ferreira, Juliana Carvalho

; Freires, Fabricio Jocundo Calado

; Machado, Flávia Ribeiro

; Cavalcanti, Alexandre Biasi

; Zampieri, Fernando Godinho

Critical Care Science

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2024, Volume 36 elocation e20240210en

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Contexto: Em estudos observacionais sobre a síndrome do desconforto respiratório agudo, sugeriu-se que a driving pressure é o principal fator de lesão pulmonar induzida por ventilador e de mortalidade. Não está claro se uma estratégia de limitação da driving pressure pode melhorar os desfechos clínicos. Objetivo: Descrever o protocolo e o plano de análise estatística que serão usados para testar se uma estratégia de limitação da driving pressure envolvendo a titulação da pressão positiva expiratória final de acordo com a melhor complacência respiratória e a redução do volume corrente é superior a uma estratégia padrão envolvendo o uso da tabela de pressão positiva expiratória final baixa do protocolo ARDSNet, em termos de aumento do número de dias sem ventilador em pacientes com síndrome do desconforto respiratório agudo devido à pneumonia adquirida na comunidade. Métodos: O estudo STAMINA (ventilator STrAtegy for coMmunIty acquired pNeumoniA) é randomizado, multicêntrico e aberto e compara uma estratégia de limitação da driving pressure com a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet em pacientes com síndrome do desconforto respiratório agudo moderada a grave devido à pneumonia adquirida na comunidade internados em unidades de terapia intensiva. Esperamos recrutar 500 pacientes de 20 unidades de terapia intensiva brasileiras e duas colombianas. Eles serão randomizados para um grupo da estratégia de limitação da driving pressure ou para um grupo de estratégia padrão usando a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet. No grupo da estratégia de limitação da driving pressure, a pressão positiva expiratória final será titulada de acordo com a melhor complacência do sistema respiratório. Desfechos: O desfecho primário é o número de dias sem ventilador em 28 dias. Os desfechos secundários são a mortalidade hospitalar e na unidade de terapia intensiva e a necessidade de terapias de resgate, como suporte de vida extracorpóreo, manobras de recrutamento e óxido nítrico inalado. Conclusão: O STAMINA foi projetado para fornecer evidências sobre se uma estratégia de limitação da driving pressure é superior à estratégia da tabela de pressão positiva expiratória final baixa do protocolo ARDSnet para aumentar o número de dias sem ventilador em 28 dias em pacientes com síndrome do desconforto respiratório agudo moderada a grave. Aqui, descrevemos a justificativa, o desenho e o status do estudo. Contexto sugeriuse sugeriu clínicos Objetivo ARDSNet Métodos ventilator pNeumoniA randomizado 50 2 colombianas Desfechos resgate extracorpóreo inalado Conclusão Aqui justificativa 5

ABSTRACT Background: Driving pressure has been suggested to be the main driver of ventilator-induced lung injury and mortality in observational studies of acute respiratory distress syndrome. Whether a driving pressure-limiting strategy can improve clinical outcomes is unclear. Objective: To describe the protocol and statistical analysis plan that will be used to test whether a driving pressure-limiting strategy including positive end-expiratory pressure titration according to the best respiratory compliance and reduction in tidal volume is superior to a standard strategy involving the use of the ARDSNet low-positive end-expiratory pressure table in terms of increasing the number of ventilator-free days in patients with acute respiratory distress syndrome due to community-acquired pneumonia. Methods: The ventilator STrAtegy for coMmunIty acquired pNeumoniA (STAMINA) study is a randomized, multicenter, open-label trial that compares a driving pressure-limiting strategy to the ARDSnet low-positive end-expiratory pressure table in patients with moderate-to-severe acute respiratory distress syndrome due to community-acquired pneumonia admitted to intensive care units. We expect to recruit 500 patients from 20 Brazilian and 2 Colombian intensive care units. They will be randomized to a driving pressure-limiting strategy group or to a standard strategy using the ARDSNet low-positive end-expiratory pressure table. In the driving pressure-limiting strategy group, positive end-expiratory pressure will be titrated according to the best respiratory system compliance. Outcomes: The primary outcome is the number of ventilator-free days within 28 days. The secondary outcomes are in-hospital and intensive care unit mortality and the need for rescue therapies such as extracorporeal life support, recruitment maneuvers and inhaled nitric oxide. Conclusion: STAMINA is designed to provide evidence on whether a driving pressure-limiting strategy is superior to the ARDSNet low-positive end-expiratory pressure table strategy for increasing the number of ventilator-free days within 28 days in patients with moderate-to-severe acute respiratory distress syndrome. Here, we describe the rationale, design and status of the trial. Background ventilatorinduced induced pressurelimiting limiting unclear Objective endexpiratory end expiratory lowpositive low ventilatorfree free communityacquired community Methods (STAMINA multicenter openlabel open label moderatetosevere moderate severe units 50 Outcomes inhospital hospital support oxide Conclusion Here rationale 5

https://doi.org/10.62675/2965-2774.20240210-en

Sarcoid-like reaction induced by neoadjuvant immunotherapy in Stage III non-small cell lung cancer Sarcoidlike Sarcoid like nonsmall non small
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Machado, Leonardo Chaves

; Fonseca, Eduardo Kaiser Ururahy Nunes

; Oliveira Júnior, Genival Viana de

; Schvartsman, Gustavo

; Chate, Rodrigo Caruso

einstein (São Paulo)

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2024, Volume 22 elocation eAI0810

Resumo: En | Texto: En | PDF: En

https://doi.org/10.31744/einstein_journal/2024ai0810

Advantages of whole-exome sequencing over immunomapping in 67 Brazilian patients with epidermolysis bullosa wholeexome whole exome 6
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Kelmann, Samantha Vernaschi

; Stephan, Bruno de Oliveira

; Barbosa, Silvia Maria de Macedo

; Polastrini, Rita Tiziana Verardo

; Oliveira, Zilda Najjar Prado de

; Rivitti-Machado, Maria Cecília

; Spolador, Gustavo Marquezani

; Honjo, Rachel Sayuri

; Saida, Ken

; Matsumoto, Naomichi

; Kim, Chong Ae

Anais Brasileiros de Dermatologia

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2024, Volume 99 Nº 3 Páginas 350 - 356

Resumo: En | Texto: En | PDF: En

Abstract Background Epidermolysis bullosa (EB) is characterized by skin fragility and blistering. In Brazil, the diagnosis is usually obtained through immunomapping, which involves a skin biopsy. Most recently, whole exome sequencing (WES) has become an important tool for the diagnosis of the subtypes of EB, providing information on prognosis as well as allowing appropriate genetic counseling for the families. Objective To compare the results of immunomapping and molecular analysis and to describe the characteristics of a Brazilian cohort of patients with EB. Methods Patients were submitted to clinical evaluation and WES using peripheral blood samples. WES results were compared to those obtained from immunomapping testing from skin biopsies. Results 67 patients from 60 families were classified: 47 patients with recessive dystrophic EB (DEB), 4 with dominant DEB, 15 with EB simplex (EBS), and 1 with junctional EB (JEB). Novel causative variants were: 10/60 (16%) in COL7A1 associated with recessive DEB and 3 other variants in dominant DEB; one homozygous variant in KRT5 and another homozygous variant in PLEC, both associated with EBS. Immunomapping was available for 59 of the 67 patients and the results were concordant with exome results in 37 (62%), discordant in 13 (22%), and inconclusive in 9 patients (15%). Study limitations Even though EB is a rare disease, for statistical purposes, the number of patients evaluated by this cohort can still be considered limited; other than that, there was a significant difference between the proportion of types of EB (only one case with JEB, against more than 50 with DEB), which unfortunately represents a selection bias. Also, for a small subset of families, segregation (usually through Sanger sequencing) was not an option, usually due to deceased or unknown parent status (mostly the father). Conclusion Although immunomapping has been useful in services where molecular studies are not available, this invasive method may provide a misdiagnosis or an inconclusive result in about 1/3 of the patients. This study shows that WES is an effective method for the diagnosis and genetic counseling of EB patients. (EB blistering Brazil biopsy recently (WES samples biopsies 6 classified , (DEB) EBS, EBS (EBS) JEB. JEB . (JEB) 1060 10 10/6 16% 16 (16% COLA COL A COL7A KRT PLEC 5 62%, 62 62% (62%) 22%, 22 22% (22%) 15%. 15% (15%) disease purposes limited only DEB) bias Also option mostly father. father father) 1/ (DEB (EBS (JEB 106 10/ (16 (62% 2 (22% (15% (1 (62 (22 (15 ( (6 (2

https://doi.org/10.1016/j.abd.2023.07.002

10.

The high biodiversity of benthic organisms in a coastal ecosystem revealed by an integrative approach
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Amaral, A. Cecília Z.

; Cunha, Beatriz P.

; Checon, Helio H.

; Godoy, Angélica S. de

; Silva, Camila F. da

; Corte, Guilherme N.

; Nogueira, João M. de M.

; Fukuda, Marcelo V.

; Steiner, Tatiana M.

; Kawauchi, Gisele Y.

; Turra, Alexander

; Denadai, Márcia R.

; Ferreira, Luciane

; Mendonça, Joel B. de

; Tavares, Marcos

; Leite, Fosca P. P.

; Costa, Mariana F. B.

; Siqueira, Silvana G. L.

; Vieira, Leandro M.

; Dias, Gustavo M.

; Teixeira, Joyce A.

; Rocha, Rosana M.

; Gusmão, Luciana C.

; Borges, Michela

; Alitto, Renata

; Machado, Fabrizio M.

; Passos, Flávio D.

; Cunha, Carlo M.

; Simone, Luiz R.L.

; Araujo, Ana Paula G.

; Carbayo, Fernando

; Bahia, Juliana

; Bulnes, Verónica N.

; Castello-Branco, Cristiana

; Hajdu, Eduardo

; Vilas-Boas, Ana Carolina

; Garraffoni, André R. S.

; Schockaert, Ernest

; Fonseca, Gustavo

; Domenico, Maikon Di

; Curini-Galletti, Marco

; Sørensen, Martin V.

; Hochberg, Rick

; Oliveira, Ana Julia F. C. de

; Zampieri, Bruna Del B.

; Chinelatto, Roberta M.

; Migotto, Alvaro E.

Biota Neotropica

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2024, Volume 24 Nº 2 elocation e20231583

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O aumento da modificação dos habitats e da perda de espécies demanda esforços consistentes para descrever e compreender os padrões de biodiversidade. O programa BIOTA/FAPESP foi criado nesse contexto e é uma iniciativa de sucesso para promover estudos em biodiversidade e conservação no Brasil. O BIOTA/Araçá é um projeto interdisciplinar que promoveu uma avaliação detalhada da biodiversidade da Baía do Araçá, um ecossistema costeiro localizado ao Norte do estado de São Paulo, Sudeste do Brasil. A baía engloba múltiplos habitats, tais como praias, manguezais, costões rochosos, e uma planície de maré, e também fornece importantes serviços ecossistêmicos. Infelizmente, a baía está sujeita à conflitos sócio-ambientais complexos que contrastam demandas econômicas, sociais e ambientais (i.e. a expansão das atividades do porto vizinho vs. a pesca artesanal de pequena escala e a proteção da biodiversidade). O presente estudo apresenta um levantamento das espécies bentônicas que ocorrem nos diferentes habitats da Baía do Araçá, incluindo dados obtidos durante o projeto BIOTA/Araçá e de investigações realizadas anteriormente na área. As espécies bentônicas desempenham um papel importante no ambiente marinho, e estudar a diversidade desses organismos que vivem associados ao fundo é indispensável para compreender o funcionamento do meio ambiente. A macrofauna, meiofauna, e microorganismos associados aos fundos consolidado e inconsolidado foram listados, e informações adicionais foram fornecidas para cada espécie, tais como a distribuição geográfica e nos habitats. O checklist inclui 826 espécies, quase 70% registradas durante o projeto BIOTA/Araçá. Os taxa mais especiosos foram os anelídeos (225 spp.), moluscos (194 spp.), e crustáceos (177 spp.). Entre as espécies bentônicas listadas, sete são endêmicas da Baía do Araçá, 14 são consideradas ameaçadas de extinção, e sete são exploradas economicamente. A baía é a localidade tipo de vários taxa, e 11 novas espécies bentônicas foram descritas com base em espécimes amostrados durante o projeto. Este projeto mostra a importância da Baía do Araçá como um ambiente de riqueza biológica única e demonstra a necessidade de esforços para a sua conservação considerando as atuais ameaças. BIOTAFAPESP BIOTA FAPESP Brasil BIOTAAraçá Paulo praias manguezais rochosos maré ecossistêmicos Infelizmente sócioambientais sócio econômicas i.e. ie i (i.e vs . biodiversidade) área marinho macrofauna meiofauna listados espécie 82 70 225 (22 spp., spp spp. , spp.) 194 (19 177 (17 spp.. listadas 1 extinção economicamente ameaças i.e 8 7 22 (2 19 (1 17 2 (

Abstract Increasing habitat modification and species loss demand consistent efforts to describe and understand biodiversity patterns. The BIOTA/FAPESP Program was created in this context and it has been a successful initiative to promote studies on biodiversity and conservation in Brazil. The BIOTA/Araçá is an interdisciplinary project that provided a detailed evaluation of the biodiversity of Araçá Bay, a coastal seascape located on the North coast of the state of São Paulo, Southeast Brazil. The bay encompasses multiple habitats, such as beaches, mangroves, rocky shores, and a tidal flat, and provides important ecosystem services. Unfortunately, the bay is the subject of complex social-environmental conflicts that oppose economic, social, and environmental demands (i.e., the expansion of neighboring harbor activities vs. small-scale artisanal fisheries and protection of biodiversity). The present study presents a survey of the benthic species occurring in the different habitats of Araçá Bay, including data obtained during the BIOTA/Araçá project and previous assessments of the area. The benthic species play an important role in marine environments and studying the diversity of these organisms that live associated with the bottom is indispensable for comprehending the environment’s functioning. The macrofauna, meiofauna, and microorganisms associated with soft and hard bottom were listed, and additional information, such as the habitat and geographical distribution, were provided for each species. The checklist includes 826 species, almost 70% recorded during the BIOTA/Araçá project. The most speciose taxa were the annelids (225 spp.), mollusks (194 spp.), and crustaceans (177 spp.). Seven benthic species are endemic to Araçá Bay, 14 are considered threatened, and seven are economically exploited. Furthermore, the bay is the type locality of many taxa, and 11 new benthic species were described based on specimens sampled during the project. This project shows the importance of Araçá Bay as a unique biologically rich environment and highlights the need for conservation efforts in light of the current threats. patterns BIOTAFAPESP BIOTA FAPESP Brazil BIOTAAraçá Paulo beaches mangroves shores flat services Unfortunately socialenvironmental social economic i.e., ie i e (i.e. vs smallscale small scale biodiversity. . biodiversity) area s functioning macrofauna meiofauna listed information distribution 82 70 225 (22 spp., spp spp. , spp.) 194 (19 177 (17 spp.. 1 threatened exploited Furthermore threats i.e. (i.e 8 7 22 (2 19 (1 17 i.e 2 (

https://doi.org/10.1590/1676-0611-bn-2023-1583

11.

Bone-marrow mononuclear cells and acellular human amniotic membrane improve global cardiac function without inhibition of the NLRP3 Inflammasome in a rat model of heart failure Bonemarrow Bone marrow NLRP
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TAKEJIMA, ALINE L.

; MACHADO-JÚNIOR, PAULO ANDRÉ B.

; BLUME, GUSTAVO G.

; SIMEONI, ROSSANA BAGGIO

; FRANCISCO, JULIO CESAR

; TONIAL, MURILO S.

; MARQUEZE, LUIS FELIPE B.

; NORONHA, LUCIA

; OLANDOSKI, MARCIA

; ABDELWAHID, ELTYEB

; CARVALHO, KATHERINE A.T. DE

; PINHO, RICARDO A.

; GUARITA-SOUZA, LUIZ CÉSAR

Anais da Academia Brasileira de Ciências

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2024, Volume 96 Nº 1 elocation e20230053

Resumo: En | Texto: En | PDF: En

Abstract Recent studies have suggested that therapies with stem cells and amniotic membrane can modulate the inflammation following an ischemic injury in the heart. This study evaluated the effects of bone-marrow mononuclear cells (BMMC) and acellular human amniotic membrane (AHAM) on cardiac function and NLRP3 complex in a rat model of heart failure.On the 30th day,the echocardiographic showed improvements on ejection fraction and decreased pathological ventricular remodeling on BMMC and AHAM groups.Oxidative stress analysis was similar between the three groups,and the NLRP3 inflammasome activity were not decreased with the therapeutic use of both BMMC and AHAM,in comparison to the control group. bonemarrow bone marrow (BMMC (AHAM NLRP failureOn failure On th daythe day groupsOxidative groups Oxidative groupsand AHAMin group

https://doi.org/10.1590/0001-3765202420230053

12.

Assessing peri-implant bone microarchitecture: conventional vs. osseodensification drilling - ex vivo analysis periimplant peri implant microarchitecture vs
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Bittar, Breno Fortes

; Sotto-Maior, Bruno Salles

; Devito, Karina Lopes

; Rabelo, Gustavo Davi

; Machado, Alessandra Silveira

; Lopes, Ricardo Tadeu

; Assis, Neuza Maria Souza Picorelli

Brazilian Dental Journal

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2024, Volume 35 elocation e24-5599

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo deste estudo foi avaliar a estabilidade de implante e a microarquitetura óssea em duas técnicas de fresagem, comparando a técnica convencional (CT) e a osseodensificação (OD) (Versah Burs - Jackson - Mississippi - EUA). O torque de inserção do implante (IT), quociente de estabilidade primária (ISQ) e a estrutura trabecular peri-implantar foram avaliados em fragmentos ósseos obtidos de tíbia de porco (n=12), divididos entre CT (n=6) e OD (n=6). Após o procedimento de fresagem, foram instalados implantes (3,5x8,5 mm, Epikut - SIN - São Paulo - Brasil). O IT e o ISQ foram aferidos por meio de um torquimetro digital e análise de frequência de ressonância. Em seguida, os fragmentos ósseos contendo os implantes foram removidos com trefina e analisados por microtomografia computadorizada (µCT, 8,0 µm). A comparação entre os grupos foi realizada por meio do teste-t não-pareado (α=0.05). Os resultados revelaram que a OD promove maior torque de inserção (CT: 7,67 ± 2,44º Ncm; OD: 19,78 ± 5,26 Ncm) (p=0,0005), embora a estabilidade primária não tenha sido diferente (CT: 61.33 ± 4.66; OD:63.25 ± 4.58) (p=0,48). Houve um aumento significativo no volume ósseo peri-implantar (CT: 23,17±3,39 mm3; OD: 32,01±5,75 mm3) (p=0,0089) e parâmetros trabeculares: separação (CT: 0,4357 ± 0,03 mm; OD: 0,3865 ± 0,04 mm) (p=0,0449), número (CT: 1,626 ± 0,18 1/mm; OD: 1,946 ± 0,13 1/mm) (p=0,007) e espessura (CT: 0,1130 ± 0,009 mm; OD: 0,1328 ± 0,015 mm) (p=0,02) O índice de modelo estrutural (SMI) não demostrou diferença estatisticamente significativa (p=0.1228). Concluindo, OD apresenta maiores valores de torque de inserção e promove mudanças benéficas na microarquitetura óssea em comparação com a TC, revelando maior volume ósseo peri-implantar. fresagem (CT (OD Versah EUA. EUA . EUA) IT, , (IT) (ISQ periimplantar peri implantar n=12, n12 n n=12 12 (n=12) n=6 n6 6 (n=6 n=6. 3,5x8,5 35x85 x 3 5x8 5 (3,5x8, mm Brasil. Brasil Brasil) ressonância seguida µCT, µCT (µCT 80 8 0 8, µm. µm µm) testet teste t nãopareado pareado α=0.05. α005 α α=0.05 05 (α=0.05) 767 7 67 7,6 244º º 2 44º Ncm 1978 19 78 19,7 526 26 5,2 p=0,0005, p00005 p p=0,0005 0005 (p=0,0005) 6133 61 33 61.3 4.66 466 4 66 OD63.25 OD6325 63.25 63 25 OD:63.2 4.58 458 58 p=0,48. p048 p=0,48 48 (p=0,48) 2317339 23 17 39 23,17±3,3 mm3 3201575 32 01 75 32,01±5,7 p=0,0089 p00089 0089 (p=0,0089 trabeculares 04357 4357 0,435 003 03 0,0 03865 3865 0,386 004 04 p=0,0449, p00449 p=0,0449 0449 (p=0,0449) 1626 1 626 1,62 018 18 0,1 1/mm 1mm 1946 946 1,94 013 13 p=0,007 p0007 007 (p=0,007 01130 1130 0,113 0009 009 0,00 01328 1328 0,132 0015 015 0,01 p=0,02 p002 02 (p=0,02 SMI (SMI p=0.1228. p01228 p=0.1228 1228 (p=0.1228) Concluindo TC periimplantar. implantar. (IT n1 n=1 (n=12 n= (n= 3,5x8, 35x8 5x (3,5x8 α00 α=0.0 (α=0.05 76 7, 197 19, 52 5, p0000 p=0,000 000 (p=0,0005 613 61. 4.6 46 OD63 OD63.2 OD632 6325 63.2 OD:63. 4.5 45 p04 p=0,4 (p=0,48 231733 23,17±3, 320157 32,01±5, p=0,008 p0008 008 (p=0,008 0435 435 0,43 00 0, 0386 386 0,38 p0044 p=0,044 044 (p=0,0449 162 62 1,6 194 94 1,9 p=0,00 p000 (p=0,00 0113 113 0,11 0132 132 001 p=0,0 p00 (p=0,0 p0122 p=0.122 122 (p=0.1228 (n=1 (n 3,5x8 35x (3,5x α0 α=0. (α=0.0 (p=0,000 4. OD6 OD63. 632 63. OD:63 p0 p=0, (p=0,4 23173 23,17±3 32015 32,01±5 043 43 0,4 038 38 0,3 p004 p=0,04 (p=0,044 16 1, 9 011 11 (p=0, p012 p=0.12 (p=0.122 3,5x α=0 (α=0. OD:6 p=0 2317 23,17± 3201 32,01± (p=0,04 (p=0 p01 p=0.1 (p=0.12 α= (α=0 p= 231 23,17 320 32,01 (p= p=0. (p=0.1 (α= 23,1 32,0 (p (p=0. (α 23, 32,

Abstract: The aim was to evaluate primary implant stability and bone microarchitecture in two drilling situations, by comparing the conventional technique (CT) and osseodensification (OD) (Versah Burs - Jackson - Mississippi - USA). The implant insertion torque (IT), implant stability quotient (ISQ), and the peri-implant trabecular microstructure were assessed on bone fragments obtained from pig’s tibia (n=12), divided between CT (n=6) and OD (n=6). After the drilling procedure, the implants were installed (3.5x8.5 mm, Epikut - SIN - São Paulo - Brazil). The IT and ISQ were measured using a digital torque wrench and resonance frequency analysis. Then, the bone fragments containing the implants were removed with a trephine and analyzed by Microtomography (µCT, 8.0 µm). The comparison between groups was performed using the unpaired t-test (α=0.05). The results revealed that OD promotes a higher insertion torque (CT: 7.67±2.44 Ncm; OD: 19.78±5.26 Ncm) (p=0.0005), although ISQ was not different (CT: 61.33±4.66; OD: 63.25±4.58) (p=0.48). There was a significant increase in peri-implant bone volume (CT: 23.17±3.39 mm3; OD: 32.01±5.75 mm3) (p=0.008), and trabecular parameters: separation (CT: 0.4357±0.03 mm; OD: 0.3865±0.04 mm) (p=0.0449), number (CT: 1.626±0.18 1/mm; OD: 1.946±0.13 1/mm) (p=0.007), and thickness (CT: 0.1130±0.009 mm; OD: 0.1328±0.015 mm) (p=0.02). Structure model index (SMI) data demonstrate no significant differences between groups (CT: 1.7±0.2; OD: 1.4±0.4) (p=0.12). In conclusion, OD increases the insertion torque values and promotes beneficial changes regarding bone microarchitecture compared with CT, revealing more peri-implant bone volume with consequent higher primary stability. Abstract situations (CT (OD Versah USA. USA . USA) IT, , (IT) ISQ, (ISQ) periimplant peri pigs pig s n=12, n12 n n=12 12 (n=12) n=6 n6 6 (n=6 n=6. procedure 3.5x8.5 35x85 x 3 5x8 5 (3.5x8. mm Brazil. Brazil Brazil) analysis Then µCT, µCT (µCT 80 8 0 8. µm. µm µm) ttest t test α=0.05. α005 α α=0.05 05 (α=0.05) 767244 7 67 2 44 7.67±2.4 Ncm 1978526 19 78 26 19.78±5.2 p=0.0005, p00005 p p=0.0005 0005 (p=0.0005) 61.33±4.66 6133466 61 33 4 66 63.25±4.58 6325458 63 25 58 p=0.48. p048 p=0.48 48 (p=0.48) 2317339 23 17 39 23.17±3.3 mm3 3201575 32 01 75 32.01±5.7 p=0.008, p0008 p=0.008 008 (p=0.008) parameters 04357003 4357 03 0.4357±0.0 03865004 3865 04 0.3865±0.0 p=0.0449, p00449 p=0.0449 0449 (p=0.0449) 1626018 1 626 18 1.626±0.1 1/mm 1mm 1946013 946 13 1.946±0.1 p=0.007, p0007 p=0.007 007 (p=0.007) 011300009 1130 009 0.1130±0.00 013280015 1328 015 0.1328±0.01 p=0.02. p002 p=0.02 02 (p=0.02) SMI (SMI 1.7±0.2 1702 1.4±0.4 1404 p=0.12. p012 p=0.12 (p=0.12) conclusion (IT (ISQ n1 n=1 (n=12 n= (n= 3.5x8. 35x8 5x (3.5x8 α00 α=0.0 (α=0.05 76724 7.67±2. 197852 19.78±5. p0000 p=0.000 000 (p=0.0005 61.33±4.6 613346 63.25±4.5 632545 p04 p=0.4 (p=0.48 231733 23.17±3. 320157 32.01±5. p000 p=0.00 00 (p=0.008 0435700 435 0.4357±0. 0386500 386 0.3865±0. p0044 p=0.044 044 (p=0.0449 162601 62 1.626±0. 194601 94 1.946±0. (p=0.007 01130000 113 0.1130±0.0 01328001 132 0.1328±0.0 p00 p=0.0 (p=0.02 1.7±0. 170 1.4±0. 140 p01 p=0.1 (p=0.12 (n=1 (n 3.5x8 35x (3.5x α0 α=0. (α=0.0 7672 7.67±2 19785 19.78±5 (p=0.000 61.33±4. 61334 63.25±4. 63254 p0 p=0. (p=0.4 23173 23.17±3 32015 32.01±5 (p=0.00 043570 43 0.4357±0 038650 38 0.3865±0 p004 p=0.04 (p=0.044 16260 1.626±0 19460 9 1.946±0 0113000 11 0.1130±0. 0132800 0.1328±0. (p=0.0 1.7±0 1.4±0 14 (p=0.1 3.5x α=0 (α=0. 767 7.67± 1978 19.78± 61.33±4 6133 63.25±4 6325 p=0 (p=0. 2317 23.17± 3201 32.01± 04357 0.4357± 03865 0.3865± (p=0.04 1626 1.626± 1946 1.946± 011300 0.1130±0 013280 0.1328±0 1.7± 1.4± α= (α=0 76 7.67 197 19.78 61.33± 613 63.25± 632 p= (p=0 231 23.17 320 32.01 0435 0.4357 0386 0.3865 162 1.626 194 1.946 01130 0.1130± 01328 0.1328± 1.7 1.4 (α= 7.6 19.7 61.33 63.25 (p= 23.1 32.0 043 0.435 038 0.386 16 1.62 1.94 0113 0.1130 0132 0.1328 1. (α 7. 19. 61.3 63.2 (p 23. 32. 0.43 0.38 1.6 1.9 011 0.113 013 0.132 61. 63. 0.4 0.3 0.11 0.13 0. 0.1

https://doi.org/10.1590/0103-6440202405599

13.

MULTIDIMENSIONAL VIEW OF THE HEALTH LITERACY LEVEL OF ADULT PATIENTS IN PRIMARY HEALTHCARE
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Cavalcanti, Euni de Oliveira

; Mariano, Elaine Alves

; Machado, Maria Eduarda da Penha

; Santos, Gustavo Henrique de Sousa

; Mendes, Hislayne de Carvalho

; Silva, Isael de Oliveira

; Dias, Marcos da Silva

; Paranaguá, Thatianny Tanferri de Brito

Texto & Contexto - Enfermagem

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2024, Volume 33 elocation e20240082

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

RESUMO Objetivo: identificar as condições de letramento em saúde e sua associação com o perfil sociodemográfico e clínico da população atendida na atenção primária à saúde. Método: estudo transversal realizado com 386 pacientes atendidos em uma Unidade Básica de Saúde no Distrito Federal, Brasil. Foi realizada entrevista individual, utilizando questionário para coleta de dados sociodemográfico e de saúde dos pacientes, além da versão brasileira do Health Literacy Questionnaire. A coleta de dados ocorreu entre maio e agosto de 2022 e os dados foram analisados por meio de estatística descritiva e inferencial. Resultados: a maioria dos participantes do estudo era composta por mulheres (76,1%), na faixa etária de 18 a 40 anos (76,1%), com autopercepção de saúde classificada como boa (38%). Os escores médios do Health Literacy Questionnaire variaram entre 2,36 e 3,73, indicando limitações no letramento em saúde, especialmente nas escalas de ‘Compreensão e apoio dos profissionais de saúde’ (2,36), ‘Informações suficientes para cuidar da saúde’ (2,52), ‘Cuidado ativo’ (2,67) e ‘Navegar no sistema de saúde’ (2,98). Conclusão: os dados encontrados indicam fatores que podem ser trabalhados na população estudada para ampliar o nível de letramento em saúde, com o objetivo de aumentar a autonomia do paciente e sua corresponsabilização para um cuidado primário contínuo, resolutivo e seguro. Objetivo Método 38 Federal Brasil individual 202 inferencial Resultados 76,1%, 761 76,1% , 76 1 (76,1%) 4 38%. 38% . (38%) 236 2 36 2,3 373 3 73 3,73 Compreensão 2,36, (2,36) Informações 2,52, 252 2,52 52 (2,52) Cuidado ativo 2,67 267 67 (2,67 Navegar 2,98. 298 2,98 98 (2,98) Conclusão contínuo seguro 20 76,1 7 (76,1% (38% 23 2, 37 3,7 (2,36 25 2,5 5 (2,52 2,6 26 6 (2,6 29 2,9 9 (2,98 76, (76,1 (38 3, (2,3 (2,5 (2, (2,9 (76, (3 (2 (76 ( (7

ABSTRACT Objective: to identify the conditions of health literacy and their association with the sociodemographic and clinical profile of the population treated in primary healthcare. Method: a cross-sectional study was conducted with 386 patients treated at a Basic Health Unit in the Federal District, Brazil. Individual interviews were conducted using a questionnaire to collect sociodemographic and health data from patients, in addition to the Brazilian version of the Health Literacy Questionnaire. Data collection took place between May and August 2022, and the data were analyzed using descriptive and inferential statistics. Results: the majority of study participants were women (76.1%), aged 18 to 40 years (76.1%), with self-perceived health classified as good (38%). The average scores on the Health Literacy Questionnaire ranged from 2.36 to 3.73, indicating limitations in health literacy, especially on the scales of ‘Understanding and support from health professionals’ (2.36), ‘Sufficient information to take care of health’ (2.52), ‘Active care’ (2.67) and ‘Navigating the health system’ (2.98). Conclusion: the data found indicate factors that can be worked on in the studied population to increase the level of health literacy, with the aim of increasing patient autonomy and their co-responsibility for continuous, effective and safe primary care. Objective healthcare Method crosssectional cross sectional 38 District Brazil 2022 statistics Results 76.1%, 761 76.1% , 76 1 (76.1%) 4 selfperceived self perceived 38%. 38% . (38%) 236 2 36 2.3 373 3 73 3.73 Understanding professionals 2.36, (2.36) Sufficient 2.52, 252 2.52 52 (2.52) Active 2.67 267 67 (2.67 Navigating system 2.98. 298 2.98 98 (2.98) Conclusion coresponsibility co responsibility continuous 202 76.1 7 (76.1% (38% 23 2. 37 3.7 (2.36 25 2.5 5 (2.52 2.6 26 6 (2.6 29 2.9 9 (2.98 20 76. (76.1 (38 3. (2.3 (2.5 (2. (2.9 (76. (3 (2 (76 ( (7

RESUMEN Objetivo: identificar las condiciones de alfabetización en salud y su asociación con el perfil sociodemográfico y clínico de la población atendida en la atención primaria de salud. Método: Estudio transversal realizado con 386 pacientes atendidos en una Unidad Básica de Salud del Distrito Federal, Brasil. Se realizó una entrevista individual, utilizando un cuestionario para recolectar datos sociodemográficos y de salud de los pacientes, además de la versión brasileña del Health Literacy Questionnaire. La recolección de datos se realizó entre mayo y agosto de 2022 y los datos se analizaron mediante estadística descriptiva e inferencial. Resultados: la mayoría de los participantes del estudio fueron mujeres (76,1%), con edades entre 18 y 40 años (76,1%), con autopercepción de salud clasificada como buena (38%). Las puntuaciones medias del Cuestionario de Alfabetización en Salud oscilaron entre 2,36 y 3,73, lo que indica limitaciones en la alfabetización en salud, especialmente en las escalas de ‘Comprensión y apoyo de los profesionales de la salud’ (2,36), ‘Información suficiente para cuidar la salud’ (2,52), ‘Atención activa’ (2,67) y ‘Navegación por el sistema sanitario’ (2,98). Conclusión: los datos encontrados indican factores que pueden ser trabajados en la población estudiada para incrementar el nivel de alfabetización en salud, con el objetivo de incrementar la autonomía y corresponsabilidad del paciente para una atención primaria continua, resolutiva y segura. Objetivo Método 38 Federal Brasil individual Questionnaire 202 inferencial Resultados 76,1%, 761 76,1% , 76 1 (76,1%) 4 38%. 38% . (38%) 236 2 36 2,3 373 3 73 3,73 Comprensión 2,36, (2,36) Información 2,52, 252 2,52 52 (2,52) Atención activa 2,67 267 67 (2,67 Navegación sanitario 2,98. 298 2,98 98 (2,98) Conclusión continua segura 20 76,1 7 (76,1% (38% 23 2, 37 3,7 (2,36 25 2,5 5 (2,52 2,6 26 6 (2,6 29 2,9 9 (2,98 76, (76,1 (38 3, (2,3 (2,5 (2, (2,9 (76, (3 (2 (76 ( (7

https://doi.org/10.1590/1980-265x-tce-2024-0082en

14.

Does GnRH treatment at TAI regardless of estrus occurrence increase pregnancy rate in crossbred Bos taurus suckled cows? cows
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Fernandes, Vanessa Silva

; Velho, Gabriella dos Santos

; Santos, Mateus Felipe Osório dos

; Evangelista, Kelly Alves

; Gasperin, Bernardo Garziera

; Pfeifer, Luiz Francisco Machado

; Ferreira, Rogério

; Gonçalves, Paulo Bayard Dias

; Gastal, Gustavo Desire Antunes

; Dalto, André Gustavo Cabrera

; Rovani, Monique Tomazele

Animal Reproduction

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2024, Volume 21 Nº 1 elocation e20230123

Resumo: En | Texto: En | PDF: En

Abstract The impact of GnRH treatment on the day of TAI in beef cows has received limited investigation, especially concerning its association with estrus expression. Consequently, two experiments were conducted to assess the potential of GnRH treatment on the day of TAI to enhance fertility according to the expression or not of estrus in beef cows. Experiment 1 aimed to determine ovulation rate and luteal function, while Experiment 2 aimed to determine the effect of the two GnRH treatment approaches on pregnancy rate. In Experiment 1, multiparous Brangus suckling cows (n = 17) were submitted to an 8-day TAI protocol. Estrus occurrence was evaluated based on chalk removal on D10 (TAI) and cows were assigned to receive GnRH (25µg lecirelin; im) according to the group: GnRH (n = 7), regardless of estrus expression; or selectGnRH (n = 10), only cows not detected in estrus. Ovulation rate occurring until 77h after IVD removal did not differ (p = 0.17) between GnRH (85.7%; 6/7) and selectGnRH (100%; 10/10). Also, corpus luteum size and serum progesterone concentration were not affected (p>0.05) by treatments. In Experiment 2, crossbred taurine suckled cows (n = 384) were submitted to the same protocol as described in Experiment 1 and were randomly allocated to GnRH or selectGnRH groups. There was no difference in P/AI between groups (selectGnRH = 55.6%; GnRH = 54.3%; p = 0.7) 30 days after TAI. As expected, there was a pronounced effect (p<0.0001) of estrus expression on P/AI (Estrus = 61.5%; No estrus = 33.0%), regardless of group. In summary, ovulation timing and rate and luteal function did not differ between groups. Also, GnRH administration only in cows that do not show estrus is recommended, considering hormone savings and similar conception rate. investigation Consequently n 17 8day 8 D D1 (TAI 25µg µg lecirelin im group 7, 7 , 7) 10, 10 10) h 0.17 017 0 85.7% 857 85 (85.7% 6/7 67 6 100% 100 (100% 10/10. 1010 10/10 . 10/10) Also p>0.05 p005 05 (p>0.05 treatments 384 PAI P AI 55.6% 556 55 54.3% 543 54 3 0.7 07 expected p<0.0001 p00001 0001 (p<0.0001 61.5% 615 61 5 33.0%, 330 33.0% 33 33.0%) summary recommended 0.1 01 85.7 (85.7 6/ (100 101 10/1 p>0.0 p00 (p>0.0 38 55.6 54.3 0. p<0.000 p0000 000 (p<0.000 61.5 33.0 85. (85. (10 10/ p>0. p0 (p>0. 55. 54. p<0.00 p000 00 (p<0.00 61. 33. (85 (1 p>0 (p>0 p<0.0 (p<0.0 (8 ( p> (p> p<0. (p<0. p<0 (p<0 p< (p<

https://doi.org/10.1590/1984-3143-ar2023-0123

15.

Soil carbon stocks as affected by land-use changes across the Pampa of southern Brazil landuse land use
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Machado, Jessica Maciel

; Johnson, Jonathas Carvalhedo

; Tornquist, Carlos Gustavo

; Taborda, Elena Polto

; Winck, Bruna Raquel

Revista Brasileira de Ciência do Solo

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2024, Volume 48 elocation e0230124

Resumo: En | Texto: En | PDF: En

ABSTRACT The “campos” of the Pampa are unique Brazilian ecosystems, which provide key environmental services, including C storage. These grassy ecosystems have been rapidly converted to intensive land-uses, mainly intensive grain crops (soybeans) and Eucalyptus silviculture. These new land-uses could decrease soil C stocks, depending on soil management. This study aimed to assess soil organic carbon (SOC) changes after the conversion of native grasslands to cropland (soybeans/cover crops under no-tillage) and forestry (Eucalyptus). Eight representative sites in this biome were selected for soil sampling (Alegrete-ALE, Aceguá-ACE, Jari-JAR, Jaguarão-JAG, Pinheiro Machado-PIM, Lavras-LAV, Santo Antônio das Missões-SAM, São Gabriel-SAG). Soil sampling was conducted in dug pits (0.30 m wide × 0.30 m long × 0.40 m depth) spaced by 50 m at each site, to 0.30 m depth. Soil bulk density and SOC were obtained by samples obtained with volumetric rings. Soil organic C was analyzed by dry combustion. Soil C stocks were calculated per layer and cumulatively (0.00-0.20 and 0.00-0.30 m). Soil C content was higher under grasslands in soils from sites with finer, clayey texture (ACE, JAG), and lower in soils at sites with sandier topsoil. Land-use conversion to silviculture and cropland minimally affected SOC stocks. The same pattern was observed with soil N, because of the tight connection between C and N cycles. Soil bulk density was similar across sites and layers, but higher values were measured in sites with coarser texture. Mean SOC stock of the grassland sites was 62 ± 24.6 Mg ha-1, similar to 66 Mg ha-1 reported for grasslands soils of Rio Grande do Sul State, and higher than that reported by IPCC for this region (55 ± 4.4 Mg ha-1). Adopting these default values would lead to underestimation of baseline SOC stocks in the region. Land-use conversion to cropland did not affect SOC stocks significantly, probably because of the adoption of no-tillage system with winter cover crops. Soil C stocks were lower in Eucalyptus stands in the 0.00-0.30 m soil layer, which could be attributed to intensive soil management at planting and lower soil fertility in some sites. This lack of effect of conversion on soil C was attributed to the short time since conversion and adoption of soil conservation practices (no-tillage) in cropland. The study contributed to reduce existing soil data gaps in the region and supports Brazilian public initiatives like the ABC Program and National Greenhouse Gas Inventories. campos “campos services storage landuses, landuses land uses, uses soybeans (soybeans (SOC soybeans/cover soybeanscover notillage no tillage Eucalyptus. . (Eucalyptus) AlegreteALE, AlegreteALE Alegrete ALE, ALE (Alegrete-ALE AceguáACE, AceguáACE Aceguá ACE, ACE Aceguá-ACE JariJAR, JariJAR Jari JAR, JAR Jari-JAR JaguarãoJAG, JaguarãoJAG Jaguarão JAG, JAG Jaguarão-JAG MachadoPIM, MachadoPIM Machado PIM, PIM Machado-PIM LavrasLAV, LavrasLAV Lavras LAV, LAV Lavras-LAV MissõesSAM, MissõesSAM Missões SAM, SAM Missões-SAM GabrielSAG. GabrielSAG Gabriel SAG Gabriel-SAG) 030 0 30 (0.3 0.3 040 40 0.4 depth 5 site rings combustion 0.000.20 000020 0.00 0.20 00 20 (0.00-0.2 0.000.30 000030 0.00-0.3 m. m) finer (ACE , JAG) topsoil Landuse Land use cycles layers 6 246 24 24. ha1, ha1 ha 1, 1 ha- State 55 (5 44 4 4. ha1. ha-1) significantly (no-tillage Inventories (Eucalyptus Gabriel-SAG 03 3 (0. 0. 04 000 0.000.2 00002 0.0 020 0.2 2 (0.00-0. 0.000.3 00003 0.00-0. ( (0 0.000. 0000 02 (0.00-0 0.00-0 0.000 (0.00- 0.00- (0.00 (0.0

https://doi.org/10.36783/18069657rbcs20230124

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