ABSTRACT: Protocols to artificially induce cows and heifers into lactation are effective and commercially available in Brazil. However, these protocols demand long hormonal treatments, which is debatable since little research has been done in the subject. To further understand artificial induction to lactation (AIL) protocols, we conducted two experiments. In experiment 1, our objective was to better characterize steroidal profile during an AIL protocol and assess the estradiol (E2) and progesterone (P4) serum profiles of Jersey cows (n=6) subjected to a conventional protocol. In experiment 2, we aimed to compare milk production and serum E2 concentrations of Holstein heifers induced into lactation by the standard AIL protocol (15 injections of E2 and 8 P4 injections) and by a short protocol in which the number of E2 injections and, consequently, the overall dosage of E2, were reduced (8 injections of E2 and 8 P4 injections). We hypothesized that a short AIL protocol (8 days) would be as efficient as the long standard protocol of 15 days. Our hypothesis was confirmed, since we demonstrated that a shorter protocol was able to induce lactation in Holstein heifers without hindering milk production. ABSTRACT Brazil However treatments subject (AIL experiments 1 E (E2 P (P4 n=6 n6 n 6 (n=6 2 (1 consequently ( injections. . days confirmed (E (P n= (n= (n

RESUMO: Protocolos que induzem à lactação artificial em vacas e novilhas são eficazes e estão comercialmente disponíveis no Brasil. No entanto, esses protocolos demandam longos tratamentos hormonais, o que é discutível visto que poucas pesquisas foram feitas sobre o assunto. Para entender melhor os protocolos de indução artificial à lactação (IAL), realizamos dois experimentos. Foi testada a hipótese de que um protocolo curto (oito dias) de IAL é tão eficiente quanto o protocolo padrão de 15 dias. No experimento 1 objetivou-se caracterizar o perfil esteroidal durante um protocolo de IAL e avaliou-se os perfis séricos de estradiol (E2) e progesterona (P4) de vacas Jersey (n=6) submetidas a um protocolo convencional. No experimento 2 foram comparadas a produção de leite e as concentrações séricas de E2 de novilhas holandesas induzidas à lactação pelo protocolo padrão de IAL (15 injeções de E2 e 8 injeções de P4) e por um protocolo curto, no qual o número de injeções de E2 e, consequentemente, a dosagem geral de E2 foram reduzidas (oito injeções de E2 e oito injeções de P4). A hipótese foi confirmada, demonstrado que um protocolo mais curto induziu a lactação em novilhas holandesas sem prejudicar a produção de leite. RESUMO Brasil entanto hormonais assunto IAL, , (IAL) experimentos dias objetivouse objetivou se avaliouse avaliou E (E2 P4 P (P4 n=6 n6 n 6 (n=6 convencional (1 consequentemente P4. . confirmada (IAL (E (P n= (n= ( (n

Abstract Nonalcoholic fatty liver disease (NAFLD) is a public health problem developed by different etiologies, which induces metabolic dysfunctions and triglycerides accumulation in hepatocytes. This lipid accumulation can generate lipotoxicity, inflammation and the production of reactive oxygen species, collaborating with the progression of liver pathogenesis to more deleterious stage. Among the elements that initiate the establishment of liver diseases, pesticides should be considered. Worldwide, the use of agricultural chemicals to increase food production may accumulate in the environment, affecting non-target organisms. Thus, worldwide legislation must control pesticides use to preserve economies and lives. In this context, to address pesticide toxicity, the alternative animal model, Drosophila melanogaster, emerges as relevant biotechnological tool to investigate molecular connectors of toxic mechanisms in the establishment and development of NAFLD and liver diseases. In this review a comprehensive explanation about pesticides on human health and the use of Drosophila melanogaster as an alternative approach to defeat NAFLD will be presented. (NAFLD etiologies hepatocytes lipotoxicity species stage diseases considered Worldwide environment nontarget non target organisms Thus lives context toxicity model presented

Resumen Objetivo conocer el itinerario terapéutico de los niños con labio hendido y/o paladar hendido. Método estudio cualitativo descriptivo realizado con familias de niños con labio y paladar hendido. La recolección de datos se realizó entre junio y julio de 2022 mediante entrevistas semiestructuradas, y se aplicó análisis de contenido temático. Resultados participaron ocho familias y surgieron tres categorías: I) Frente a lo desconocido: diagnóstico de labio y paladar hendido en niños: se observaron sentimientos de shock, miedo e incertidumbre que permean durante el diagnóstico temprano o tardío; II) Un camino arduo: pausas e inicios durante el itinerario terapéutico – se observó que las familias siguieron caminos diferentes debido a la especificidad de la configuración familiar y de la propia hendidura; III) Tejer la red de apoyo para la atención: el apoyo de amigos, familiares, profesionales e instituciones de salud resultó ser extremadamente necesario. Conclusiones e implicaciones para la práctica el itinerario terapéutico de los niños con labio y paladar hendido es arduo y está acompañado de desafíos, que comienzan desde el diagnóstico y continúan después del nacimiento. Se espera que los resultados de este estudio fomenten el diálogo entre los profesionales de la salud y conozcan las necesidades de esta población y puedan actuar en los diferentes puntos de la atención en salud. yo 202 semiestructuradas temático categorías I desconocido shock tardío II hendidura III amigos familiares necesario desafíos nacimiento 20 2

Abstract Objective to understand the therapeutic itinerary of children with cleft lip and/or palate. Method a descriptive qualitative study carried out with families of children with cleft lip and palate. Data collection took place between June and July 2022 through semi-structured interviews, and thematic content analysis was applied. Results eight families participated and three categories emerged: I) Facing the unknown: diagnosis of cleft lip and palate in children – feelings of shock, fear and uncertainty were noted that permeate during early or late diagnosis; II) An arduous path: pauses and beginnings during the therapeutic itinerary – it was observed that the families followed different paths due to the specificity of the family configuration and the cleft itself; III) Weaving the support network for care – support from friends, family, professionals and health institutions proved to be extremely necessary. Conclusions and implications for practice the therapeutic itinerary of children with cleft lip and palate is arduous and followed by challenges, which begin at diagnosis and continue after birth. It is hoped that the results of this study will encourage dialogue among health professionals and become familiar with the needs of this population and be able to act at different points of health care. andor 202 semistructured semi structured interviews applied emerged I unknown shock II path itself III friends necessary challenges birth 20 2

Resumo Objetivo conhecer o itinerário terapêutico de crianças com fissuras de lábio e/ou palato. Método estudo descritivo de natureza qualitativa realizado com famílias de crianças com fissura labiopalatina. A coleta de dados ocorreu entre junho e julho de 2022 por meio de entrevistas semiestruturadas, e aplicou-se a análise de conteúdo temática. Resultados participaram oito famílias e emergiram três categorias: I) Enfrentando o desconhecido: diagnóstico de fissura labiopalatina na criança – notaram-se sentimentos de choque, medo e incerteza que permeiam durante o diagnóstico precoce ou tardio; II) Um caminho árduo: pausas e recomeços durante o itinerário terapêutico – observou-se que as famílias percorreram caminhos diferentes devido à especificidade da configuração familiar e da própria fissura; III) Tecendo a rede de apoio para o cuidado – mostrou-se ser de extrema necessidade o apoio dos amigos, família, profissionais e instituições de saúde. Conclusões e implicações para prática o itinerário terapêutico de crianças com fissura labiopalatina é árduo e acompanhado de desafios, que se iniciam no diagnóstico e permanecem após o nascimento. Espera-se que os resultados deste estudo suscitem o diálogo entre os profissionais de saúde e se familiarizem com as necessidades dessa população e possam atuar nos diferentes pontos de atenção à saúde. eou palato 202 semiestruturadas aplicouse aplicou temática categorias I desconhecido notaramse notaram choque tardio II observouse observou III mostrouse mostrou amigos família desafios nascimento Esperase Espera 20 2

Abstract This study is the first to apply training impulse (TRIMP) and Training Monotony (TM) methodologies, within the realm of sport science, in animal model studies. Rats were divided into Sedentary (SED, n=10) and Training (TR, n=13). TR performed a four-week moderate-intensity interval training with load progression. Lactate kinetics, lactate training impulse (TRIMPLac), maximal speed training impulse (TRIMPSmax) and TM were utilized to develop and monitor training protocol. TR showed an 11.9% increase in time to exhaustion at the second maximum incremental test and a 17.5% increase at the third test. External work was increased by 17.8% at the second test and 30.3% at the third. There was a 10.6% increase in external work at the third test compared to the second for TR. No difference in TRIMPLac between the 1st week (94±9 A.U) and 3rdweek (83±10 A.U) were seen. TRIMPSmax was 2400 A.U. in the 1st week, 2760 A.U. in the 2nd and 3rd weeks, and 3120 A.U. in the 4th week. The TM remained at 1.24 A.U throughout the protocol and there was no dropouts. TRIMPLac and TRIMPSmax contributed to the development and monitoring loads, demonstrating their potential to improve the accuracy of training protocols in animal model research. TRIMP (TRIMP (TM methodologies science studies SED, SED (SED n=10 n10 n 10 TR, (TR n=13. n13 n=13 . 13 n=13) fourweek four moderateintensity moderate intensity progression kinetics TRIMPLac, , (TRIMPLac) (TRIMPSmax 119 11 9 11.9 175 17 5 17.5 178 8 17.8 303 30 3 30.3 106 6 10.6 st 94±9 949 94 (94± AU A U rdweek 83±10 8310 83 (83±1 seen 240 276 nd rd weeks 312 th 124 1 24 1.2 dropouts loads research n=1 n1 (TRIMPLac 11. 17. 30. 10. 94± (94 83±1 831 (83± 27 31 12 2 1. n= (9 83± (83 ( (8

Aim The main purpose of this study was to conduct a narrative review investigating the possible relationship between permanent maxillary anterior teeth and anthropometric facial parameters in different populations. Methods Searches were performed in the PubMed, BVS (Biblioteca Virtual em Saúde) and SciELO databases to identify relevant scientific articles using the following search terms: “maxillary anterior teeth”, “facial measurements” and “anthropometry”, in such a way that 218 publications were found. After application of inclusion and exclusion criteria, 13 publications remained for full-text reading. Results All studies involved male and female samples and it was notorious that male measurements were unanimously higher than those obtained in the opposite sex. The age of the analyzed participants ranged from 17 to 60 years; however, a mean age of 18 to 25 years was the most investigated in literature. In addition, facial measurements including the bizygomatic width, interpupillary distance, intercanthal distance, interalar width and intercommissural width have been proposed to help determine the correct size of anterior teeth. Conclusion It was concluded that despite the limited number of studies, some factors that influence dental and facial dimensions, such as sex and age, can be identified. However, there is no standardization of the facial or dental parameters used in the studies, a fact that makes it difficult to establish a universal ratio for clinical dental practice. populations PubMed Biblioteca Saúde terms teeth, , teeth” anthropometry, anthropometry “anthropometry” 21 found criteria 1 fulltext full text reading 6 however 2 literature addition distance dimensions identified However practice “anthropometry

Abstract Background: People with haemophilia (PwH) are living longer. Therefore, they can develop atherosclerotic cardiovascular disease (ASCVD). Electrocardiogram (ECG) alterations may be a sign of initial ASCVD before the occurrence of symptoms. Objective: To describe the prevalence of resting ECG alterations among PwH adults asymptomatic for ASCVD. Methods: PwH aged ≥ 30 years without previous ASCVD events were considered for the analysis. Resting ECG traces were analysed according to international reference values and the Brazilian Longitudinal Adult Health Study (ELSA-Brasil) results for asymptomatic Brazilian men. Based on the established normal values and using the QT index, we further described the altered ECGs as minor or major changes, according to the Minnesota Code. Differences between prevalences were evaluated by Pearson's χ2 test. Differences between medians were evaluated by the Mann-Whitney U test. A p-value < 0.05 was accepted as statistically significant. Results: A total of 64 PwH were included in the study. Median age was 44 years (interquartile range 35-52). Most patients had haemophilia A (81%) and 47% were severe. The prevalence of obesity, systemic arterial hypertension (SAH), diabetes mellitus (DM), and dyslipidaemia were 16%, 56%, 14%, and 72%, respectively. All the PwH had sinus rhythm, except for one, who had an implanted pacemaker due to idiopathic third-degree atrioventricular block. Altered ECGs were found in 25% and 30% of PwH, according to established criteria and ELSA-Brasil criteria, respectively. Major changes were found in eight (13%) PwH according to the Minnesota Code, including two ECGs with ischaemia-like wall inactivity. Conclusions: The prevalence of altered ECG varied from 25% to 30% among asymptomatic PwH. Background (PwH longer Therefore . (ASCVD) (ECG symptoms Objective Methods 3 analysis ELSABrasil ELSA Brasil (ELSA-Brasil men index Code Pearsons Pearson s χ test MannWhitney Mann Whitney pvalue p value 005 0 05 0.0 significant Results 6 study 4 interquartile 3552. 3552 35 52 35-52) 81% 81 (81% 47 severe obesity SAH, SAH , (SAH) DM, DM (DM) 16 16% 56 56% 14 14% 72 72% respectively rhythm one thirddegree third degree block 25 13% 13 (13% ischaemialike ischaemia like inactivity Conclusions (ASCVD 00 0. 355 5 35-52 8 (81 (SAH (DM 1 7 2 (13 35-5 (8 (1 35- (

ABSTRACT Objective: This study aimed to assess the consistency of data regarding the provision of fluoridation in Brazilian municipalities with water supply systems. Methods: Official data from the National Basic Sanitation Survey and the National Information System on Sanitation for 2017 were compared. Results: Out of 5,570 municipalities in Brazil, 4,546 (81.6%) had water supply systems. The agreement between data sources was 84%, with a Kappa of 0.668, indicating substantial agreement. However, the estimates of fluoridation provision exhibited an average discrepancy of 8.1 percentage points, ranging from 1.2 points in the Central-West region to 21.4 points in the Northeast region. Conclusion: To address these inconsistencies, it is essential to enhance information sources, ensuring more reliable data for health, sanitation authorities, and society at large. Objective systems Methods 201 compared Results 5570 5 570 5,57 Brazil 4546 4 546 4,54 81.6% 816 81 6 (81.6% 84 84% 0668 0 668 0.668 However 8 1 8. 12 2 1. CentralWest Central West 214 21 21. Conclusion inconsistencies health authorities large 20 557 57 5,5 454 54 4,5 81.6 (81.6 066 66 0.66 55 5, 45 4, 81. (81. 06 0.6 (81 0. (8 (

RESUMO Objetivo: Avaliar a consistência dos dados sobre a provisão de fluoretação em municípios brasileiros com sistemas de abastecimento de água. Métodos: Foram comparados os dados da Pesquisa Nacional de Saneamento Básico e do Sistema Nacional de Informações sobre Saneamento referentes a 2017. Resultados: De 5.570 municípios no Brasil, 4.546 (81,6%) possuíam sistemas de água. A concordância entre as fontes foi de 84%, com Kappa de 0,668, indicando substancial concordância. Entretanto, as estimativas de provisão divergiram em média 8,1 pontos percentuais, variando de 1,2 ponto na região Centro-Oeste a 21,4 pontos na região Nordeste. Conclusão: Para superar essa inconsistência, é fundamental aprimorar as fontes de informação, garantindo dados mais confiáveis para as autoridades de saúde, saneamento e para a sociedade em geral. Objetivo água Métodos 2017 Resultados 5570 5 570 5.57 Brasil 4546 4 546 4.54 81,6% 816 81 6 (81,6% 84 84% 0668 0 668 0,668 Entretanto 8 1 8, percentuais 12 2 1, CentroOeste Centro Oeste 214 21 21, Nordeste Conclusão inconsistência informação saúde geral 201 557 57 5.5 454 54 4.5 81,6 (81,6 066 66 0,66 20 55 5. 45 4. 81, (81, 06 0,6 (81 0, (8 (

Abstract Introduction COVID-19 could leave important consequences, including functional decline. Objective Eval-uate functional status in pediatric patients hospitalized with COVID-19 and correlate with clinical variables. Methods Prospective and retrospective longitudinal study with patients with COVID-19. Hospitalization data were collected from medical record review and post discharge data were collected by telephone contact. Functional status was evaluated by Functional Status Scale (FSS-Brazil) in three moments (hospital admission, hospi-tal discharge and after hospital discharge). Spearman test was used to correlate continuous variables and the linear model with generalized estimation equations was used to verify differences in the proportion of functional impairment occurrence (FSS-Brazil ≥ 8) at different mo-ments of the study and previous disease presence. Results It was included 232 patients, 56% male, median age of five years old. Seventy (30.2%) patients had post discharge data. The mean global score of FSS-Brazil was 7.3 at hospital admission, 6.8 at discharge hospital and 6.8 after discharge hospital. Functional status was adequate in the three different moments evaluated in 75% of the sample. The ventilatory support needed was not correlated with functional status and the length of hos-pital stay and oxygen therapy showed weak correlations with functional status. Having no previous disease reduced the risk of functional impairment by 94%. Conclusion The majority of the patients maintained adequate functional status. Absence of previous disease was a protective factor for long term functional impairment. COVID19 COVID 19 COVID-1 consequences decline Evaluate Eval uate COVID19. 19. contact FSSBrazil FSS Brazil admission hospi tal discharge. . discharge) 8 mo ments presence 23 56 male old 30.2% 302 30 2 (30.2% 73 7 3 7. 68 6 6. 75 sample hos pital 94 94% COVID1 1 COVID- 5 30.2 (30.2 9 30. (30. (30 (3 (

Resumo Introdução A COVID-19 pode deixar sequelas impor-tantes, como declínio funcional. Objetivo Avaliar a funcionalidade dos pacientes pediátricos internados com COVID-19 e correlacionar com variáveis clínicas. Métodos Estudo longitudinal retrospectivo e prospectivo, com pacientes pediátricos com COVID-19. Os dados de internação hospitalar foram coletados a partir da revisão de prontuários e os dados pós-alta através de contato telefônico. A funcionalidade foi avaliada através da Escala de Estado Funcional Pediátrica (FSS-Brasil) em três momentos (admissão, alta e pós-alta hospitalar). A correlação entre as variáveis contínuas foi avaliada pelo teste de Spearman e utilizou-se o modelo linear com equações de estimação generalizada para verificar as diferenças nas proporções de ocorrência de prejuízo funcional (FSS-Brasil ≥ 8) nos diferentes momentos do estudo e na presença de doenças prévias. Resultados Foram incluídos 232 pacientes, 56% do sexo masculino, mediana de 5 anos de idade. Foram obtidos dados de seguimento pós-alta hospitalar de 70 (30,2%) crianças. O escore global médio da FSS-Brasil foi de 7,3 na admissão, 6,8 na alta e 6,8 após a alta. A funcionalidade apresentou-se adequada nos três momentos de avalia-ção em 75% da amostra. A necessidade de suporte ven-tilatório não foi correlacionado com a funcionalidade, e o tempo de internação e oxigenoterapia apresentaram correlações fracas com a funcionalidade. A inexistência de doenças prévias reduziu em 94% o risco de prejuízo funcional. Conclusão A maioria das crianças manteve funcionalidade adequada. Não ter doenças prévias foi um fator de proteção para o prejuízo funcional em longo prazo. COVID19 COVID 19 COVID-1 importantes, importantes impor tantes, tantes impor-tantes clínicas prospectivo COVID19. 19. pósalta pós telefônico FSSBrasil FSS Brasil admissão (admissão hospitalar. . hospitalar) utilizouse utilizou se 8 23 56 masculino idade 7 30,2% 302 30 2 (30,2% 73 3 7, 68 6 6, apresentouse apresentou avaliação avalia ção 75 amostra ventilatório ven tilatório 94 prazo COVID1 1 COVID- 30,2 (30,2 9 30, (30, (30 (3 (

ABSTRACT Purpose To propose a methodology for analyzing data generated by an instrument measuring non-nutritive sucking pressure in newborns. Methods An analytical observational study was developed, with a cross-sectional design, considering the data collected from 24 full-term newborns without complications. Three collections from each neonate were analyzed, with duration of 2 minutes and a 2-minute interval between them. The defined parameters were extracted using a program developed in Matlab®. The results were obtained by analyzing and comparing 12 variables at a 5% confidence level. Comparison of manual and computerized analyzes was also carried out using the intraclass correlation coefficient. Results The multiple comparison between the three collection moments showed that the significant statistical differences occurred between collections one and two and two and three. When analyzing and comparing each variable separately, it was noted that the second collection showed: greater number of sucking groups, greater number of suctions, less time to start the sucking groups, longer time of sucking groups, less number of sporadic suctions, higher mean pressure values and with less standard deviation, more number of pauses with shorter time of pauses. The intraclass correlation coefficient revealed almost perfect agreement for the 12 evaluated parameters. Conclusion The 12 variables analyzed are relevant, especially in the second collection. The Matlab® program proved to be viable and effective in extracting and analyzing parameters, showing high agreement when compared to manual evaluation. nonnutritive non nutritive crosssectional cross sectional design fullterm full term complications 2minute minute them Matlab 1 5 level separately groups suctions deviation relevant evaluation

RESUMO Objetivo Propor uma metodologia de análise dos dados gerados por um instrumento de medição da pressão de sucção não-nutritiva do recém-nascido. Método Estudo observacional analítico, transversal com dados de 24 recém-nascidos a termo sem comprometimentos. Após a avaliação clínica foram analisadas três coletas de cada neonato empregando-se o referido instrumento, com duração de 2 minutos e intervalo de 2 minutos entre elas. Os parâmetros definidos foram extraídos por meio de um programa desenvolvido em Matlab®. Os resultados foram obtidos pela análise e comparação de 12 variáveis ao nível de confiança de 5%. Foi realizada ainda comparação das análises manual e computadorizada por meio do coeficiente de correlação intraclasse. Resultados A comparação múltipla entre os três momentos de coleta, mostrou que as diferenças estatísticas significantes ocorreram entre as coletas um e dois e dois e três. Ao se analisar e comparar cada variável separadamente, notou-se que a segunda coleta apresentou: maior número de grupos de sucção, maior número de sucções, menor tempo para iniciar os grupos de sucção, maior tempo de grupos de sucção, menor número de sucções esporádicas, valores de pressão média maiores e com menor desvio padrão, maior número de pausas com tempo de pausas menor. O coeficiente de correlação intraclasse revelou concordância quase perfeita para os 12 parâmetros avaliados. Conclusão As 12 variáveis analisadas mostram-se relevantes, especialmente na segunda coleta. O programa em Matlab® mostrou-se viável e eficaz na extração e análise dos parâmetros, apresentando alta concordância quando comparado à avaliação manual. nãonutritiva não nutritiva recémnascido. recémnascido recém nascido. nascido recém-nascido analítico recémnascidos nascidos comprometimentos empregandose empregando elas Matlab 1 5 5% separadamente notouse notou apresentou esporádicas padrão avaliados mostramse mostram relevantes mostrouse

ABSTRACT The objective of this study was to monitor the temporal variation in penetration resistance (PR) after soil saturation under different management systems in three areas of the Cerrado biome: two in no-till systems (NT with 3 and 10 years of implementation) and one of crop-livestock integration (CL with 9 years of implementation) with soybean/forage succession. Four transects were delimited in each area. The delimited area was saturated and the PR measurements were performed daily for 11 days at 10 transect points, up to 0.40 m of depth. Soil moisture was determined with PR measurements, soil hydraulic conductivity, and organic carbon. PR values were more significant in the 0.10 - 0.20 m layer than in the 0.0 - 0.10 and 0.20 - 0.40 m layers. The NT-3 area showed a lower PR value (1.65 MPa) than the area under NT-10 and CL-9, with 2.48 and 2.69 MPa, respectively. Thus, critical soil moisture values, that is, soil moisture values most susceptible to soil compaction were determined. Thus, in the NT-3 area, the critical moisture was 0.20 kg kg-1, in the NT-10, ranged from 0.19 - 0.20 kg kg-1, and in the CL-9, between 0.23 and 0.20 kg kg-1. Monitoring soil moisture can prevent management operations from restricting root growth. (PR biome notill no till NT 1 implementation croplivestock crop livestock CL soybeanforage soybean forage succession points 040 0 40 0.4 depth conductivity carbon 010 0.1 020 20 0.2 00 0. layers NT3 NT- 1.65 165 65 (1.6 MPa NT10 NT-1 CL9, CL9 9, CL-9 248 2 48 2.4 269 69 2.6 respectively Thus is kg1, kg1 1, kg-1 NT10, 10, 019 19 023 23 kg1. 1. growth 04 4 01 02 1.6 16 6 (1. NT1 CL- 24 2. 26 kg- (1 (

ABSTRACT Objective: to analyze the patient care flow in a Hemodynamics service grounded on Lean Thinking based on Value Stream Mapping. Method: an exploratory-descriptive case study carried out in the Hemodynamics service of a public university hospital from southern Brazil. Data collection was conducted through participant observation with twelve members of the multiprofessional team and interviews with five participants from May 2021 to February 2022. The analysis was based on the Lean framework and on the stages foreseen in Value Stream Mapping. Results: the Value Stream Map of the current situation of the service was prepared, identifying suppliers and customers of the process and their requirements. A total of 61 problems related to unmet requirements were listed, of which 12 were prioritized in order to promote improvement planning. Conclusion: with Value Stream Mapping it was possible to establish improvement priorities that exert impacts on operational performance of the service. It was identified that improvements related to standardization of the activities minimize waste from failures and waiting times, which were the most prevalent in the service, among others observed. Objective Method exploratorydescriptive exploratory descriptive Brazil 202 2022 Results prepared 6 listed 1 planning Conclusion times observed 20 2

RESUMO Objetivo: analisar o fluxo do atendimento de pacientes em um serviço de hemodinâmica sustentado no pensamento Lean com base no Mapa de Fluxo de Valor. Método: estudo de caso, exploratório-descritivo, realizado no serviço de hemodinâmica de um hospital público universitário do sul do Brasil. A coleta de dados ocorreu por meio de observação participante com doze integrantes da equipe multiprofissional e entrevistas com cinco participantes no período de maio de 2021 a fevereiro de 2022. A análise sustentou-se no referencial Lean e nas etapas previstas no Mapa de Fluxo de Valor. Resultados: elaborou-se o Mapa de Fluxo de Valor da situação atual do serviço, identificando-se fornecedores e clientes do processo e seus requisitos. Elencaram-se 61 problemas relacionados a requisitos não atendidos, dos quais 12 foram priorizados, a fim de promover o planejamento de melhorias. Conclusão: com o Mapa de Fluxo de Valor foi possível estabelecer prioridades de melhoria que impactam no desempenho operacional do serviço. Identificou-se que melhorias relacionadas à padronização das atividades minimizam os desperdícios de falha e espera, que foram os mais prevalentes no serviço, entre outros observados. Objetivo Método caso exploratóriodescritivo, exploratóriodescritivo exploratório descritivo, descritivo exploratório-descritivo Brasil 202 2022 sustentouse sustentou se Resultados elaborouse elaborou identificandose identificando Elencaramse Elencaram 6 atendidos 1 priorizados Conclusão Identificouse Identificou espera observados 20 2

RESUMEN Objetivo: analizar el flujo de la atención provista a los pacientes en un servicio de Hemodinámica, sustentado en la filosofía Lean sobre la base del Mapa de Flujo de Valor. Método: estudio de casos, exploratorio y descriptivo, realizado en el servicio de Hemodinámica de un hospital público universitario del sur de Brasil. Los datos se recolectaron por medio de observación participante con doce integrantes del equipo multiprofesional y de entrevistas con cinco participantes entre mayo de 2021 y febrero de 2022. El análisis se sustentó en el referencial Lean y en las etapas previstas en el Mapa de Flujo de Valor. Resultados: se elaboró el Mapa de Flujo de Valor correspondiente a la situación actual del servicio, con la debida identificación de proveedores y clientes del proceso y sus requisitos. Se elaboró una lista con 61 problemas relacionados a requisitos no cumplidos, 12 de los cuales 12 fueron priorizados con el fin de promover la planificación de mejoras. Conclusión: con el Mapa de Flujo de Valor fue posible establecer prioridades de mejora que ejercieron un impacto sobre el desempeño operativo del servicio. Se identificó que las mejoras relacionadas con la estandarización de las actividades minimizan los desperdicios por fallas y esperas, que fueron los más prevalentes en el servicio, entre otros observados. Objetivo Método casos descriptivo Brasil 202 2022 Resultados 6 cumplidos 1 Conclusión esperas observados 20 2

RESUMO Objetivo: Avaliar associação entre estressores ocupacionais e transtornos mentais comuns (TMC) entre trabalhadores e trabalhadoras "invisíbilizados" da saúde, no contexto da pandemia de COVID-19. Métodos: Estudo transversal com amostra probabilística de 1.014 trabalhadores(as) da saúde de três municípios baianos. Os TMC foram avaliados pelo SRQ-20. A escala Desequilíbrio Esforço-Recompensa (DER) e o Modelo Demanda-Controle avaliaram os estressores ocupacionais. Análise descritiva, bivariada e múltipla avaliaram associação entre as variáveis de interesse. Resultados: A prevalência global de TMC foi de 39,9%, sendo mais elevada entre os Agentes Comunitários de Saúde/Agente de Combate às Endemias — ACS/ACE (47,2%), seguidos pelo pessoal da gestão e vigilância (38,6%), técnicos (35,4%) e pessoal de apoio/conservação/limpeza (29,9%). A associação entre estressores ocupacionais e TMC variou entre as ocupações: 1. Comprometimento excessivo com o trabalho (CET), DER e demandas psicológicas associaram-se aos TMC entre trabalhadores de apoio/conservação/limpeza; 2. CET e DER estavam associadas aos TMC entre ACS/ACE; 3. CET, DER e baixo controle sobre o trabalho associaram-se aos TMC entre os técnicos; 4. Entre trabalhadores de gestão e vigilância, apenas o DER estava associado aos TMC. Conclusões: Estressores ocupacionais tiveram papel relevante no adoecimento mental, com variação entre os estratos de ocupação, demandando atenção, acompanhamento e controle. Objetivo (TMC invisíbilizados "invisíbilizados COVID19. COVID19 COVID 19. 19 COVID-19 Métodos 1014 1 014 1.01 trabalhadoresas trabalhadores(as baianos SRQ20. SRQ20 SRQ 20. 20 SRQ-20 EsforçoRecompensa Esforço Recompensa (DER DemandaControle Demanda Controle descritiva interesse Resultados 399 39 9 39,9% SaúdeAgente Saúde Agente ACSACE ACS ACE 47,2%, 472 47,2% , 47 2 (47,2%) 38,6%, 386 38,6% 38 6 (38,6%) 35,4% 354 35 4 (35,4% apoioconservaçãolimpeza apoio conservação limpeza 29,9%. 299 29,9% . 29 (29,9%) ocupações (CET) associaramse associaram se 3 Conclusões mental ocupação atenção COVID1 COVID-1 101 01 1.0 SRQ2 SRQ-2 39,9 47,2 (47,2% 38,6 (38,6% 35,4 (35,4 29,9 (29,9% (CET COVID- 10 0 SRQ- 39, 47, (47,2 38, (38,6 35, (35, 29, (29,9 (47, (38, (35 (29, (47 (38 (3 (29 (4 ( (2

ABSTRACT Objective: To evaluate the association between occupational stressors and common mental disorders (CMD) among "invisible" health workers in the context of the COVID-19 pandemic. Method: Cross-sectional study including a probabilistic sample of 1,014 health workers from three municipalities in Bahia. CMDs were assessed using the SRQ-20. The Effort-Reward Imbalance (ERI) scale and the Demand-Control Model assessed occupational stressors. Descriptive, bivariate, and multiple analysis to evaluate the association between the variables of interest. Results: The global prevalence of CMD was 39.9%; it was higher among CHA/EDCA (47.2%), followed by management and surveillance staff (38.6%), technicians (35.4%), and support/maintenance/cleaning staff (29.9%). The association between occupational stressors and CMD varied among occupations: 1. Excessive work commitment (EWC), effort-reward imbalance (ERI), and psychological demand were associated with CMD among support/maintenance/cleaning workers; 2. EWC and ERI were associated with CMD among CHA/EDCA; 3. EWC, ERI, and low control over work were associated with CMD among technicians; 4. Among management and surveillance workers, only ERI remained associated with CMD. Conclusions: Occupational stressors played a relevant role in mental illness, with variation between occupational strata, demanding attention, monitoring, and control. Objective (CMD invisible "invisible COVID19 COVID 19 COVID-1 pandemic Method Crosssectional Cross sectional 1014 1 014 1,01 Bahia SRQ20. SRQ20 SRQ 20. 20 SRQ-20 EffortReward Effort Reward (ERI DemandControl Demand Control Descriptive bivariate interest Results 39.9% 399 39 9 CHAEDCA CHA EDCA 47.2%, 472 47.2% , 47 2 (47.2%) 38.6%, 386 38.6% 38 6 (38.6%) 35.4%, 354 35.4% 35 4 (35.4%) supportmaintenancecleaning support maintenance cleaning 29.9%. 299 29.9% . 29 (29.9%) occupations (EWC) effortreward effort reward 3 Conclusions illness strata attention monitoring COVID1 COVID- 101 01 1,0 SRQ2 SRQ-2 39.9 47.2 (47.2% 38.6 (38.6% 35.4 (35.4% 29.9 (29.9% (EWC 10 0 1, SRQ- 39. 47. (47.2 38. (38.6 35. (35.4 29. (29.9 (47. (38. (35. (29. (47 (38 (35 (29 (4 (3 (2 (

RESUMO Objective Determinar a aceitabilidade e os fatores associados à realização do exame físico para detecção de infecções sexualmente transmissíveis (IST) sintomáticas em mulheres trans e travestis no Brasil. Métodos: Foram utilizados dados do “TransOdara”, estudo transversal de prevalência de IST, realizado em cinco capitais brasileiras (Campo Grande, Manaus, Porto Alegre, Salvador e São Paulo) entre dezembro de 2019 e julho de 2021. As 1.317 mulheres trans e travestis, com idade ≥18 anos, recrutadas por meio do método respondent-driven sampling passaram por entrevistas e responderam a um questionário estruturado. Foi ofertada consulta médica, incluindo realização de exame físico e coleta de amostras de vários locais para detectar diversas IST. Para a análise dos fatores associados à aceitabilidade do exame físico (geral, genital e anorretal), considerou-se as características sociodemográficas das participantes que permitiram a sua realização. Resultados: A maioria (65,4%; intervalo de confiança – IC95% 62,7–68,0) concedeu permissão para o exame geral (incluindo orofaríngeo), com permissão concedida em menor proporção para os exames genitais (42,3%; IC95% 39,6–46,0) ou anorretais (42,1%; IC95% 39,4–44,9). No geral, 34,4% (IC95% 31,8–37,0) delas recusaram todos os exames. As participantes com sintomas de IST foram significativamente mais propensas a conceder permissão para o exame completo do que as participantes assintomáticas (64,3 vs 37,4%, odds ratio ajustado – AOR=3,6, IC95% 2,4–5,5). Os fatores significativamente associados à aceitabilidade do exame completo na análise multivariada incluíram idade (AOR=1,5 para ≥25 anos), religião (AOR=2,0 para afro-brasileiras, AOR=1,9 para outras religiões em comparação com nenhuma religião) e nível de escolaridade (AOR=2,0 para nível superior). Conclusão: No contexto do manejo de IST, nós observamos aceitação limitada de exames anogenitais entre mulheres trans e travestis, com maior aceitação entre aquelas com sintomas de IST. (IST Brasil Métodos TransOdara, TransOdara , “TransOdara” Campo Grande Manaus Alegre Paulo 201 2021 1317 1 317 1.31 18 ≥1 anos respondentdriven respondent driven estruturado médica (geral anorretal, anorretal anorretal) considerouse considerou se Resultados 65,4% 654 65 4 (65,4% IC95 IC 62,7–68,0 627680 62 7 68 0 orofaríngeo, orofaríngeo orofaríngeo) 42,3% 423 42 3 (42,3% 39,6–46,0 396460 39 6 46 42,1% 421 (42,1% 39,4–44,9. 394449 39,4–44,9 . 44 9 39,4–44,9) 344 34 34,4 (IC95 31,8–37,0 318370 31 8 37 64,3 643 64 (64, 374 37,4% AOR36 AOR AOR=3,6 2,4–5,5. 2455 2,4–5,5 2 5 2,4–5,5) AOR=1,5 AOR15 (AOR=1, 25 ≥2 anos) AOR=2,0 AOR20 (AOR=2, afrobrasileiras, afrobrasileiras afro brasileiras, afro-brasileiras AOR19 AOR=1, superior. superior superior) Conclusão “TransOdara 20 202 131 1.3 ≥ 65,4 (65,4 IC9 62,7–68, 62768 42,3 (42,3 39,6–46, 39646 42,1 (42,1 39444 39,4–44, 34, (IC9 31,8–37, 31837 64, (64 37,4 AOR3 AOR=3, 245 2,4–5, AOR1 (AOR=1 AOR=2, AOR2 (AOR=2 AOR=1 13 1. 65, (65, 62,7–68 6276 42, (42, 39,6–46 3964 3944 39,4–44 (IC 31,8–37 3183 (6 37, AOR=3 24 2,4–5 (AOR= AOR=2 AOR= (65 62,7–6 627 (42 39,6–4 396 394 39,4–4 31,8–3 318 ( 2,4– (AOR 62,7– (4 39,6– 39,4– 31,8– 2,4 62,7 39,6 39,4 31,8 2, 62, 39, 31,

ABSTRACT Objective This study aimed to determine the acceptability and factors associated with uptake of a physical examination for the detection of symptomatic sexually transmitted infections (STIs) by transgender women and travestis in Brazil. Methods: TransOdara was a multi-centric, cross-sectional STI prevalence study conducted among transgender women and travestis in five capital cities (Campo Grande, Manaus, Porto Alegre, Salvador and São Paulo) representing all Brazilian regions, between December 2019 and July 2021. A total of 1,317 self-identified transgender women and travestis aged ≥18 years were recruited using respondent-driven sampling and responded to a standard questionnaire. A medical consultation was offered including a physical examination and collection of samples from multiple sites to detect various STIs. Factors associated with uptake were investigated by reviewing demographic characteristics of participants who gave permission for physical examination (general, genital, and anorectal). Results: Most participants (65.4%, 95% confidence interval — 95%CI 62.7–68.0) gave permission for a general examination (including oropharyngeal), with fewer permitting genital (42.3%, 95%CI 39.6–46.0) or anorectal (42.1%, 95%CI 39.4–44.9) examinations. Overall, 34.4% (95%CI 31.8–37.0) of participants refused all examinations. Participants with STI symptoms were significantly more likely to give permission for full examination than asymptomatic participants (64.3 vs. 37.4%, adjusted odds ratio — AOR=3.6, 95%CI 2.4–5.5). Other factors significantly associated with uptake of a full examination in multivariate analysis included age (AOR=1.5 for ≥25 years), religion (AOR=1.7 for Afro-Brazilian, AOR=1.9 for other religions compared to no religion), and education (AOR=2.0 for higher-level). Conclusion: In the context of STI management, this study found limited acceptance of anogenital examinations among transgender women and travestis, with higher acceptance among those with STI symptoms. STIs (STIs Brazil Methods multicentric, multicentric multi centric, centric multi-centric crosssectional cross sectional Campo Grande Manaus Alegre Paulo regions 201 2021 1317 1 317 1,31 selfidentified self identified 18 ≥1 respondentdriven respondent driven questionnaire general, (general anorectal. . anorectal) Results 65.4%, 654 65 4 (65.4% 95 95CI CI 62.7–68.0 627680 62 7 68 0 oropharyngeal, oropharyngeal , oropharyngeal) 42.3%, 423 42 3 (42.3% 39.6–46.0 396460 39 6 46 42.1%, 421 (42.1% 39.4–44.9 394449 44 9 Overall 344 34 34.4 31.8–37.0 318370 31 8 37 64.3 643 64 (64. vs 374 37.4% AOR36 AOR AOR=3.6 2.4–5.5. 2455 2.4–5.5 2 5 2.4–5.5) AOR=1.5 AOR15 (AOR=1. 25 ≥2 years, years) AOR=1.7 AOR17 AfroBrazilian, AfroBrazilian Afro Brazilian, Afro-Brazilian AOR19 AOR=1. religion, religion) AOR=2.0 AOR20 (AOR=2. higherlevel. higherlevel level higher-level) Conclusion management 20 202 131 1,3 ≥ 65.4% (65.4 62.7–68. 62768 42.3% (42.3 39.6–46. 39646 42.1% (42.1 39.4–44. 39444 34. 31.8–37. 31837 64. (64 37.4 AOR3 AOR=3. 245 2.4–5. AOR1 (AOR=1 AOR=1 AOR=2. AOR2 (AOR=2 higher-level 13 1, 65.4 (65. 62.7–68 6276 42.3 (42. 39.6–46 3964 42.1 39.4–44 3944 31.8–37 3183 (6 37. AOR=3 24 2.4–5 (AOR= AOR= AOR=2 65. (65 62.7–6 627 42. (42 39.6–4 396 39.4–4 394 31.8–3 318 ( 2.4– (AOR 62.7– (4 39.6– 39.4– 31.8– 2.4 62.7 39.6 39.4 31.8 2. 62. 39. 31.

ABSTRACT Objective: To evaluate the association between occupational stressors and common mental disorders (CMD) among "invisible" health workers in the context of the COVID-19 pandemic. Method: Cross-sectional study including a probabilistic sample of 1,014 health workers from three municipalities in Bahia. CMDs were assessed using the SRQ-20. The Effort-Reward Imbalance (ERI) scale and the Demand-Control Model assessed occupational stressors. Descriptive, bivariate, and multiple analysis to evaluate the association between the variables of interest. Results: The global prevalence of CMD was 39.9%; it was higher among CHA/EDCA (47.2%), followed by management and surveillance staff (38.6%), technicians (35.4%), and support/maintenance/cleaning staff (29.9%). The association between occupational stressors and CMD varied among occupations: 1. Excessive work commitment (EWC), effort-reward imbalance (ERI), and psychological demand were associated with CMD among support/maintenance/cleaning workers; 2. EWC and ERI were associated with CMD among CHA/EDCA; 3. EWC, ERI, and low control over work were associated with CMD among technicians; 4. Among management and surveillance workers, only ERI remained associated with CMD. Conclusions: Occupational stressors played a relevant role in mental illness, with variation between occupational strata, demanding attention, monitoring, and control.

RESUMO Objetivo: Avaliar associação entre estressores ocupacionais e transtornos mentais comuns (TMC) entre trabalhadores e trabalhadoras "invisíbilizados" da saúde, no contexto da pandemia de COVID-19. Métodos: Estudo transversal com amostra probabilística de 1.014 trabalhadores(as) da saúde de três municípios baianos. Os TMC foram avaliados pelo SRQ-20. A escala Desequilíbrio Esforço-Recompensa (DER) e o Modelo Demanda-Controle avaliaram os estressores ocupacionais. Análise descritiva, bivariada e múltipla avaliaram associação entre as variáveis de interesse. Resultados: A prevalência global de TMC foi de 39,9%, sendo mais elevada entre os Agentes Comunitários de Saúde/Agente de Combate às Endemias — ACS/ACE (47,2%), seguidos pelo pessoal da gestão e vigilância (38,6%), técnicos (35,4%) e pessoal de apoio/conservação/limpeza (29,9%). A associação entre estressores ocupacionais e TMC variou entre as ocupações: 1. Comprometimento excessivo com o trabalho (CET), DER e demandas psicológicas associaram-se aos TMC entre trabalhadores de apoio/conservação/limpeza; 2. CET e DER estavam associadas aos TMC entre ACS/ACE; 3. CET, DER e baixo controle sobre o trabalho associaram-se aos TMC entre os técnicos; 4. Entre trabalhadores de gestão e vigilância, apenas o DER estava associado aos TMC. Conclusões: Estressores ocupacionais tiveram papel relevante no adoecimento mental, com variação entre os estratos de ocupação, demandando atenção, acompanhamento e controle.

ABSTRACT Objective This study aimed to determine the acceptability and factors associated with uptake of a physical examination for the detection of symptomatic sexually transmitted infections (STIs) by transgender women and travestis in Brazil. Methods: TransOdara was a multi-centric, cross-sectional STI prevalence study conducted among transgender women and travestis in five capital cities (Campo Grande, Manaus, Porto Alegre, Salvador and São Paulo) representing all Brazilian regions, between December 2019 and July 2021. A total of 1,317 self-identified transgender women and travestis aged ≥18 years were recruited using respondent-driven sampling and responded to a standard questionnaire. A medical consultation was offered including a physical examination and collection of samples from multiple sites to detect various STIs. Factors associated with uptake were investigated by reviewing demographic characteristics of participants who gave permission for physical examination (general, genital, and anorectal). Results: Most participants (65.4%, 95% confidence interval — 95%CI 62.7–68.0) gave permission for a general examination (including oropharyngeal), with fewer permitting genital (42.3%, 95%CI 39.6–46.0) or anorectal (42.1%, 95%CI 39.4–44.9) examinations. Overall, 34.4% (95%CI 31.8–37.0) of participants refused all examinations. Participants with STI symptoms were significantly more likely to give permission for full examination than asymptomatic participants (64.3 vs. 37.4%, adjusted odds ratio — AOR=3.6, 95%CI 2.4–5.5). Other factors significantly associated with uptake of a full examination in multivariate analysis included age (AOR=1.5 for ≥25 years), religion (AOR=1.7 for Afro-Brazilian, AOR=1.9 for other religions compared to no religion), and education (AOR=2.0 for higher-level). Conclusion: In the context of STI management, this study found limited acceptance of anogenital examinations among transgender women and travestis, with higher acceptance among those with STI symptoms.

RESUMO Objective Determinar a aceitabilidade e os fatores associados à realização do exame físico para detecção de infecções sexualmente transmissíveis (IST) sintomáticas em mulheres trans e travestis no Brasil. Métodos: Foram utilizados dados do “TransOdara”, estudo transversal de prevalência de IST, realizado em cinco capitais brasileiras (Campo Grande, Manaus, Porto Alegre, Salvador e São Paulo) entre dezembro de 2019 e julho de 2021. As 1.317 mulheres trans e travestis, com idade ≥18 anos, recrutadas por meio do método respondent-driven sampling passaram por entrevistas e responderam a um questionário estruturado. Foi ofertada consulta médica, incluindo realização de exame físico e coleta de amostras de vários locais para detectar diversas IST. Para a análise dos fatores associados à aceitabilidade do exame físico (geral, genital e anorretal), considerou-se as características sociodemográficas das participantes que permitiram a sua realização. Resultados: A maioria (65,4%; intervalo de confiança – IC95% 62,7–68,0) concedeu permissão para o exame geral (incluindo orofaríngeo), com permissão concedida em menor proporção para os exames genitais (42,3%; IC95% 39,6–46,0) ou anorretais (42,1%; IC95% 39,4–44,9). No geral, 34,4% (IC95% 31,8–37,0) delas recusaram todos os exames. As participantes com sintomas de IST foram significativamente mais propensas a conceder permissão para o exame completo do que as participantes assintomáticas (64,3 vs 37,4%, odds ratio ajustado – AOR=3,6, IC95% 2,4–5,5). Os fatores significativamente associados à aceitabilidade do exame completo na análise multivariada incluíram idade (AOR=1,5 para ≥25 anos), religião (AOR=2,0 para afro-brasileiras, AOR=1,9 para outras religiões em comparação com nenhuma religião) e nível de escolaridade (AOR=2,0 para nível superior). Conclusão: No contexto do manejo de IST, nós observamos aceitação limitada de exames anogenitais entre mulheres trans e travestis, com maior aceitação entre aquelas com sintomas de IST.