Abstract Background: Pemphigus constitutes a group of autoimmune bullous diseases. A reduction in the incidence of endemic pemphigus foliaceus and an increase in pemphigus vulgaris has been described, but there are no studies in Minas Gerais that address the subject. Objective: To describe the epidemiological and clinical profile of patients with pemphigus treated at the Dermatology Service of a public University Hospital in the state of Minas Gerais, Brazil. Methods: An observational, descriptive, and cross-sectional study was carried out of cases of endemic pemphigus foliaceus and pemphigus vulgaris, for a period of six months. A questionnaire was filled out with epidemiological and clinical data on the disease. Results: A total of 122 patients were included in the study, 64 with endemic pemphigus foliaceus and 58 with pemphigus vulgaris. When comparing patients with endemic pemphigus foliaceus and those with pemphigus vulgaris, a statistical difference was observed between the median age of initial disease manifestation (p = 0.001), patient occupation (p = 0.010), area of residence (p = 0.000), forests (p = 0.000) and rivers/streams close to the dwelling (p = 0.001) and the number of systemic medications required to control the disease (p = 0.002). When comparing patients with endemic pemphigus foliaceus to those evaluated in a study carried out at the same service in 2008, there was a statistical difference in the area of residence (p = 0.030). Study limitations: The assessed population comes from a tertiary care service that is not a reference for the entire state. Conclusions: Patients with endemic pemphigus foliaceus and pemphigus vulgaris maintain statistically significant differences regarding their main variables in the literature, such as age and area of residence. Historically, there has been a reduction in cases of endemic pemphigus foliaceus and an increase in cases of pemphigus vulgaris in this population. Background diseases described subject Objective Brazil Methods observational descriptive crosssectional cross sectional months Results 12 6 5 p 0.001, 0001 0.001 , 0 001 0.010, 0010 0.010 010 0.010) 0.000, 0000 0.000 000 riversstreams rivers streams 0.002. 0002 0.002 . 002 0.002) 2008 0.030. 0030 0.030 030 0.030) limitations Conclusions literature Historically 1 0.00 00 0.01 01 200 003 0.03 03 0.0 20 0. 2

ABSTRACT: The objectives of this study were to assess the effects of i) pre-incubation storage time of Pekin duck eggs on incubation parameters and ii) different levels of in ovo injection with maltodextrin on Pekin duckling weight. The study was divided into two experiments using hatching eggs of Cherry Valley SM2 hens with egg-laying ages between 31 and 40 weeks. In experiment I, 8,820 eggs were subjected to different periods of pre-incubation storage (one-seven days). For experiment II, 120 eggs weighing between 75 and 85 g were selected and inoculated with 250 µL of 0.75% saline solution with different concentrations of maltodextrin treatments (0%, 1.5%, 3.0%, and 4.5%). In relation to pre-incubation storage time, eggs stored for one day had lower hatching and hatchability rates and higher duckling mortality rates than eggs stored for longer periods (P < 0.05). In ovo injection with 3.0% maltodextrin in 0.75% saline solution significantly increased the hatching weight of Pekin ducklings (53.62 g) compared to that by other study treatments (P < 0.05). Therefore, Pekin duck eggs produced between 31 and 40 weeks of life may be stored between two and seven days without affecting hatchery productivity parameters. The hatching weight of Pekin ducks may be improved with in ovoinjection with 3.0% maltodextrin in 0.75% saline solution. ABSTRACT i preincubation pre ii SM egglaying egg laying 3 4 I 8820 8 820 8,82 oneseven days. . days) II 12 7 25 075 0 0.75 0%, (0% 15 1 5 1.5% 30 4.5%. 45 4.5% 4.5%) P 0.05. 005 0.05 05 0.05) 3.0 53.62 5362 53 62 (53.6 Therefore 882 82 8,8 2 07 0.7 0% (0 1.5 4.5 00 0.0 3. 53.6 536 6 (53. 88 8, 0. ( 1. 4. 53. (53 (5

RESUMO: Os objetivos deste estudo foram i) avaliar a influência do tempo de estocagem pré-incubação dos ovos de marrecos de Pequim sobre os parâmetros de incubação, e ii) avaliar o efeito de diferentes níveis de inclusão da maltodextrina in ovo sobre o peso inicial dos pintinhos de marrecos de Pequim. O estudo foi dividido em dois experimentos, onde foram utilizados ovos incubáveis de matrizes Cherry Valley SM2 com idade de postura entre 31 e 40 semanas. No experimento I 8.820 ovos foram submetidos a diferentes períodos de estocagem pré-incubação (um a sete dias). Para o experimento II, foram selecionados 120 ovos com peso entre 75 a 85 gramas, sendo inoculado 250 µL de solução salina 0,75% associada à maltodextrina em diferentes concentrações nos tratamentos (0%, 1,5%, 3,0% e 4,5%). Em relação ao tempo de estocagem pré-incubação, os ovos estocados por um dia apresentaram menores percentuais de eclosão e eclodibilidade e maior percentual de descarte ao nascimento quando comparado com os ovos estocados por mais tempo (P< 0,05). A inoculação de 3,0% maltodextrina em solução salina 0,75% in ovo resultou em maiores peso ao nascimento dos pintinhos (53,62g), diferindo dos demais tratamentos avaliados (P< 0,05). Portanto, ovos de marrecos produzidos entre as 31 e 40 semanas de vida das aves podem ficar estocados entre dois a sete dias em sala de estocagem sem influenciar os parâmetros de produtividade do incubatório e a inclusão de 3,0% de maltodextrina associada a solução salina 0,75% in ovo melhorou o peso ao nascimento de marrecos de Pequim. RESUMO i préincubação pré incubação ii experimentos SM 3 4 8820 8 820 8.82 dias. . dias) II 12 7 gramas 25 075 0 0,75 0%, (0% 15 1 5 1,5% 30 3,0 4,5%. 45 4,5% 4,5%) préincubação, P< P (P 0,05. 005 0,05 05 0,05) 53,62g, 5362g g 53,62g , 53 62g (53,62g) Portanto 882 82 8.8 2 07 0,7 0% (0 1,5 3, 4,5 00 0,0 (53,62g 88 8. 0, ( 1, 4,

ABSTRACT We report a case of eosinophilic meningitis associated with the ingestion of raw fish (Cichla sp.) from the Brazilian Amazon, likely caused by Gnathostoma. A 36-year-old male visited Juruena river on a fishing trip. After 50 days, the patient presented with an intense frontal headache. A cerebrospinal fluid examination revealed 63% eosinophilia. Another individual who ingested raw fish developed linear dermatitis on the abdominal wall. Anti-Gnathostoma serum antibodies were detected, and the patient made a full recovery after treatment with corticosteroids and albendazole. To date, autochthonous Gnathostoma spp. infections in Latin American countries have only caused linear panniculitis. This report raises awareness of gnathostomiasis-causing meningitis. Cichla sp. sp Amazon 36yearold yearold 36 year old trip 5 days headache 63 eosinophilia wall AntiGnathostoma Anti detected albendazole date spp panniculitis gnathostomiasiscausing gnathostomiasis causing 3 6

ABSTRACT Purpose The objective of this study was analyzed the neuropsychological functions of students from a public school in Brazil, enrolled in the 1st and 2nd year of Elementary School at the time of the reopening of schools during the COVID-19 pandemic and to access the influence of family and contextual information on the performance of these skills. Methods 117 students participated in the study, as well as their parents or guardians. The children were evaluated in person using the Brief Child Neuropsychological Assessment Instrument (NEUPSILIN-Inf). The parents/guardians answered remotely the Inventory of Resources of the Family Environment and questions about socioeconomic classification and maternal education. Results The data showed a high prevalence of children who had problems or deficits in the functions of orientation, memory, language, visuospatial skills, arithmetic skills and verbal fluency. Furthermore, predictable activities that signal some degree of stability in family life are predictors of children's performance in orientation skills and resources that promote proximal processes significantly reflect on language performance. The results suggest that children included in families with a household income below one Brazilian minimum monthly salary presented poorer inhibitory control performances. Conclusion The impact of changes in neuropsychological skills in children's learning were presented and discussed, highlighting the need for immediate and targeted intervention of these functions. Contextual factors that influenced the performance of neuropsychological skills were also considered. Brazil st nd COVID19 COVID 19 COVID-1 11 guardians NEUPSILINInf. NEUPSILINInf NEUPSILIN Inf . (NEUPSILIN-Inf) parentsguardians education memory fluency Furthermore childrens s performances discussed considered COVID1 1 COVID- (NEUPSILIN-Inf

RESUMO Objetivo O objetivo desse estudo foi analisar as funções neuropsicológicas de estudantes de uma escola pública do Distrito Federal (Brasil), matriculadas 1º e 2º ano de Ensino Fundamental na reabertura das escolas públicas na pandemia da COVID-19 e a influência dos fatores familiares e contextuais sobre o desempenho dessas habilidades. Métodos Participaram 117 estudantes, bem como seus responsáveis. As crianças foram avaliadas presencialmente por meio do Instrumento de Avaliação Neuropsicológica Breve Infantil (NEUPSILIN-Inf). Os pais/responsáveis responderam remotamente ao Inventário de Recursos do Ambiente Familiar e as questões para classificação socioeconômica e de escolaridade materna. Resultado Os dados apontam alta prevalência de crianças em fase de alfabetização que apresentam alerta ou déficit das funções de orientação, memória, linguagem, habilidades visuoespaciais, habilidades aritméticas e fluência verbal. Ainda, as atividades previsíveis que sinalizam algum grau de estabilidade na vida familiar são preditoras do desempenho das crianças na habilidade de orientação e os recursos que promovem processos proximais refletem significativamente no desempenho em linguagem. Os resultados sugerem que crianças inseridas em família com estimativas da renda domiciliar abaixo de um salário mínimo apresentam piores desempenhos do controle inibitório. Conclusão Foram apresentados e discutidos os impactos das alterações das habilidades neuropsicológicas para o aprendizado das crianças, destacando a necessidade de intervenções imediatas e direcionadas para essas funções. Foram considerados os fatores contextuais que apresentaram influência sobre o desempenho das habilidades neuropsicológicas. Brasil, Brasil , (Brasil) º COVID19 COVID 19 COVID-1 11 responsáveis NEUPSILINInf. NEUPSILINInf NEUPSILIN Inf . (NEUPSILIN-Inf) paisresponsáveis pais materna memória linguagem visuoespaciais verbal Ainda inibitório (Brasil COVID1 1 COVID- (NEUPSILIN-Inf

ABSTRACT Purpose To compare the speech and voice patterns of myasthenia gravis (MG) patients over four years, and correlate the results with clinical aspects of the disease. Methods Data was collected for 4 years. The clinical assessment tools included the Quantitative Myasthenia Gravis (QMG) score, the Myasthenia Gravis Foundation of America (MGFA) clinical classification, and the Myasthenia Gravis Quality of Life 15-item Scale (MG-QoL). To assess speech, the recorded speaking tasks were analyzed acoustically and given auditory-perceptual ratings. Sex (equal distribution) and age (p=0.949) were used as matching criteria in the final sample, which consisted of 10 individuals in the MG group (MGG) and 10 individuals in the control group (CG). Results After 4 years, the MG participants presented stable health status, increased mild and moderate dysarthria (from 40% to 90% of the subjects), and a significant deterioration in the respiration, phonation, and articulation subsystems. The acoustic analysis showed a decline in articulatory patterns (speech rate p=0.047, articulation rate p=0.007, mean syllable duration p=0.007) and vocal quality (increased jitter p=0.022). In the follow-up comparison, there was a significant difference between the phonation variables (shimmer and harmonic-to-noise ratio) of the MGG and CG. Conclusion The MG patients presented a decline in speech over four years and an increase in mild and moderate dysarthria. Despite presenting stable health status, their respiratory, phonatory, and articulatory subsystems worsened. There was no correlation between speech patterns and clinical characteristics of the disease (severity and motor scale). (MG QMG (QMG score MGFA (MGFA classification 15item item 15 MGQoL. MGQoL QoL . (MG-QoL) auditoryperceptual auditory perceptual ratings equal distribution p=0.949 p0949 p 0 949 (p=0.949 sample 1 (MGG CG (CG) status from 40 90 subjects, subjects , subjects) respiration p0047 047 p=0.047 p0007 007 p=0.007 p=0.022. p0022 p=0.022 022 p=0.022) followup follow up comparison shimmer harmonictonoise harmonic noise ratio respiratory phonatory worsened severity scale. scale scale) (MG-QoL p=0.94 p094 94 (p=0.94 (CG 9 p004 04 p=0.04 p000 00 p=0.00 p002 p=0.02 02 p=0.9 p09 (p=0.9 p00 p=0.0 p=0. p0 (p=0. p=0 (p=0 p= (p= (p

RESUMO Objetivo Comparar o padrão de fala e voz de indivíduos com Miastenia Gravis (MG) em um intervalo de quatro anos e correlacionar com aspectos clínicos da doença. Método A coleta de dados foi realizada ao longo de 4 anos. A avaliação clínica foi composta pelo Quantitative Myasthenia Gravis Score (QMGS), pela Myasthenia Gravis Foundation of America Classification (MGFA) e pela escala de qualidade de vida para Miastenia Gravis (MG-QOL). A avaliação da fala foi composta por gravação de tarefas, análise perceptivo-auditiva e análise acústica. A amostra final foi composta por 10 indivíduos em MG e 10 indivíduos no grupo controle (GC), pareados por sexo (distribuição igualitária) e idade (p=0,949). Resultados Após 4 anos, os indivíduos com MG apresentaram estabilidade clínica, aumento do diagnóstico de disartria leve e moderada (de 40% para 90% dos sujeitos) e diminuição significativa no desempenho dos subsistemas da fala: respiração, fonação e articulação. Na análise acústica, houve declínio do padrão articulatório (taxa de fala p=0,047, taxa de articulação p=0,007, duração média das sílabas p=0,007) e qualidade vocal (jitter aumentado p=0,022). Houve diferença significativa nas variáveis fonatórias (shimmer e harmonic-to-noise ratio) entre os grupos MG e GC na comparação do seguimento. Conclusão Indivíduos com MG apresentaram declínio no padrão de fala em um intervalo de quatro anos, com aumento no número de disártricos (leve e moderado). Mesmo com a estabilidade da doença, houve piora dos subsistemas respiratório, fonatório e articulatório. Não houve correlação entre o padrão de fala e as características clínicas da doença (gravidade e escala motora). (MG QMGS, QMGS , (QMGS) MGFA (MGFA MGQOL. MGQOL QOL . (MG-QOL) tarefas perceptivoauditiva perceptivo auditiva acústica 1 GC, (GC) distribuição igualitária p=0,949. p0949 p p=0,949 0 949 (p=0,949) 40 90 sujeitos respiração p0047 047 p=0,047 p0007 007 p=0,007 jitter p=0,022. p0022 p=0,022 022 p=0,022) shimmer harmonictonoise harmonic to noise ratio seguimento moderado. moderado moderado) respiratório gravidade motora. motora motora) (QMGS (MG-QOL (GC p094 p=0,94 94 (p=0,949 9 p004 04 p=0,04 p000 00 p=0,00 p002 p=0,02 02 p09 p=0,9 (p=0,94 p00 p=0,0 p0 p=0, (p=0,9 p=0 (p=0, p= (p=0 (p= (p

Abstract Difficult airway management represents a major challenge, requiring a careful approach, advanced technical expertise, and accurate protocols. The task force of the Brazilian Society of Anesthesiology (SBA) presents a report with updated recommendations for the management of difficult airway in adults. These recommendations were developed based on the consensus of a group of expert anesthesiologists, aiming to provide strategies for managing difficulties during tracheal intubation. They are based on evidence published in international guidelines and opinions of experts. The report underlines the essential steps for proper difficult airway management, encompassing assessment, preparation, positioning, pre-oxygenation, minimizing trauma, and maintaining arterial oxygenation. Additional strategies for using advanced tools, such as video laryngoscopy, flexible bronchoscopy, and supraglottic devices, are discussed. The report considers recent advances in understanding crisis management, and the implementation seeks to further patient safety and improve clinical outcomes. The recommendations are outlined to be uncomplicated and easy to implement. The report underscores the importance of ongoing education, training in realistic simulations, and familiarity with the latest technologies available. challenge approach expertise protocols SBA (SBA adults anesthesiologists intubation experts assessment preparation positioning preoxygenation, preoxygenation pre oxygenation, oxygenation pre-oxygenation trauma tools laryngoscopy bronchoscopy devices discussed outcomes implement education simulations available

Abstract Given the high content of unsaturated fatty acids that high oleic sunflower oil has and thinking in terms of healthiness and innovation, this study aimed to characterize organogels and to investigate the effect of the addition of organogels in chocolate spreads to reduce saturated fatty acids (SFA). The characterization of the organogels was carried out in terms of solids fat content (SFC), crystallization kinetics, thermal behavior, polymorphism, microstructure, hardness, and rheological properties. The organogels analysed showed 5.22% to 6.20% solids at 10 °C, melted at 45 °C, and dropped to < 2.34% at 37.5 °C. Induction time was 4 to 8 minutes, with max solids at 2.29% to 4.72%. The melting and crystallization curves could be subdivided into different regions, which reflected the different classes of triacylglycerol present in the organogels. All organogels showed β polymorphism. The average diameter of the organogels was less than 30 μm, thus minimizing the perception of grittiness in the mouth resulting from the lipid phase. Hardness values varied between 3.53 and 4.58 N. The elastic modulus (G’) value was greater than the viscous modulus (G”), indicating the behavior of a solid material. The results of chocolate spreads were characterized by consistency, distribution particle size, rheological properties and dynamic turbidimetry. The range of consistency of spreads ranged from 13.83 to 631.60 gF. All chocolate spreads formulated with organogels showed particle size between 14.59 and 46.23 µm at index d 0.5 and d 0.9, respectively. As for the rheological parameters, the G' value was observed superior to G”, indicating properties of solid materials. The chocolate spreads with organogels analyzed showed characteristic stability. There was no exudation of liquid oil in the stabilization period for 36 days, thus the chocolate spreads showed a predominant elastic behavior. This characterization proves to be fundamental for the reformulation of products in terms of greater healthiness. innovation SFA. SFA . (SFA) SFC, SFC , (SFC) kinetics polymorphism microstructure hardness 522 5 22 5.22 620 6 20 6.20 1 C °C 234 2 34 2.34 375 37 37. minutes 229 29 2.29 472 72 4.72% regions 3 μm phase 353 53 3.5 458 58 4.5 N G (G’ G, (G”) material turbidimetry 1383 13 83 13.8 63160 631 60 631.6 gF 1459 14 59 14.5 4623 46 23 46.2 05 0 0. 09 9 0.9 respectively parameters G” materials stability days (SFA (SFC 52 5.2 62 6.2 2.3 2.2 47 7 4.72 35 3. 4. (G (G” 138 13. 6316 63 631. 145 14. 462 46. 5. 6. 2. 4.7

ABSTRACT Objective: To evaluate questions concerning oral medicineand pharmacology-related specialties of asynchronous dental teleconsulting sessions of the Telehealth Brazil Networks Program. Material and Methods: Data were collected from secondary databases of asynchronous dental teleconsulting sessions of the telehealth centers of Minas Gerais from July 2015 to July 2017. The variables for dental underlying fields and the types of questions were evaluated. Descriptive analysis was performed with the SPSS v.22.0 program. Results: 3,920 teleconsulting sessions were referred to the telehealth centers of Minas Gerais during the study period. Regarding oral medicine-related questions (n=745), most (n=469; 62.95%) addressed diagnosis, whereas the underlying field questions mostly regarded fungal, viral, and bacterial infections (17.3%), biopsies (16.4%), developmental defects and dental abnormalities (9.9%), and soft tissue tumors (9.4%). Pharmacology-related questions (n=738) mostly addressed general approaches (n=672; 91.06%), and the most common questions were about underlying fields' prescriptions (44.7%), anesthetics (17.6%), adverse effects of medications and anesthetics (10.2%), and selection of anesthetics for patients with systemic conditions (9.8%). Conclusion: Most teleconsulting sessions regarded conditions or procedures common in primary health care and essential for diagnosis and treatment planning at all care levels, which suggests a need for more academic learning processes for healthcare professionals, especially in dentistry primary fields. Objective pharmacologyrelated pharmacology related Program Methods 201 2017 evaluated v220 v 22 0 v.22. program Results 3920 3 920 3,92 period medicinerelated medicine n=745, n745 n n=745 , 745 (n=745) n=469 n469 469 (n=469 62.95% 6295 62 95 fungal viral 17.3%, 173 17.3% 17 (17.3%) 16.4%, 164 16.4% 16 4 (16.4%) 9.9%, 99 9.9% 9 (9.9%) 9.4%. 94 9.4% . (9.4%) Pharmacologyrelated Pharmacology n=738 n738 738 (n=738 n=672 n672 672 (n=672 91.06%, 9106 91.06% 91 06 91.06%) 44.7%, 447 44.7% 44 7 (44.7%) 17.6%, 176 17.6% 6 (17.6%) 10.2%, 102 10.2% 10 2 (10.2%) 9.8%. 98 9.8% 8 (9.8%) Conclusion levels professionals 20 v22 v.22 392 92 3,9 n74 n=74 74 (n=745 n=46 n46 46 (n=46 62.95 629 17.3 1 (17.3% 16.4 (16.4% 9.9 (9.9% 9.4 (9.4% n=73 n73 73 (n=73 n=67 n67 67 (n=67 910 91.06 44.7 (44.7% 17.6 (17.6% 10.2 (10.2% 9.8 (9.8% v2 v.2 39 3, n7 n=7 (n=74 n=4 n4 (n=4 62.9 17. (17.3 16. (16.4 9. (9.9 (9.4 (n=7 n=6 n6 (n=6 91.0 44. (44.7 (17.6 10. (10.2 (9.8 v. n= (n= 62. (17. (16. (9. 91. (44. (10. (n (17 (16 (9 (44 (10 (1 ( (4

BACKGROUND Leprosy is a highly neglected disease that is considered a serious public health problem in many countries. This illness is characterised by a variety of clinical and histopathological manifestations that are related to the patient immune response. OBJECTIVES This work aimed evaluate the profile of circulating immune mediators in the plasma from patients classified clinically as paucibacillary (PB), multibacillary (MB), households contacts (HHC), type1 leprosy reaction (T1R), type2 leprosy reaction (T2R) and control individuals without medical history of leprosy (CTL). METHODS To assessment of the plasma immune mediators was used multiplex microbeads immunoassay “Luminex”. FINDINGS The results showed that patients (PB) had a regulatory-biased profile, while MB revealed a pro-inflammatory trend of highly expressed biomarkers. HHC display conspicuously increased levels in the plasma of the chemokines (CCL2, CCL3, CCL4, CCL5 and CXCL8), pro-inflammatory cytokines (IFN-γ,TNF and IL-1β), modulating cytokines (IL-9 and IL-1Ra) and growth factors (PDGF, G-CSF and IL-2). Interestingly, HHC displayed superior production of IFN-γ as compared to other leprosy groups, indicating a putative protective role for this cytokine during chronic Mycobacterium leprae exposure. MAIN CONCLUSION Further investigations are currently underway to elucidate the potential of these mediators as biomarkers applicable to the diagnosis/prognosis of leprosy and also T1R and T2R leprosy reactions. countries response PB, PB , MB, (MB) HHC, (HHC) type T1R, TR T R (T1R) (T2R CTL. CTL . (CTL) Luminex. Luminex “Luminex” (PB regulatorybiased regulatory biased proinflammatory pro inflammatory CCL2, CCL2 CCL (CCL2 CCL3 CCL4 CXCL8, CXCL8 CXCL CXCL8) IFNγ,TNF IFNγTNF IFN γ,TNF γ TNF IL1β, IL1β ILβ IL 1β β IL-1β) IL9 9 (IL- IL1Ra ILRa 1Ra Ra IL-1Ra PDGF, PDGF (PDGF GCSF G CSF IL2. IL2 2 IL-2) Interestingly IFNγ groups exposure diagnosisprognosis diagnosis prognosis reactions (MB (HHC (T1R (CTL “Luminex (CCL γTNF IL-1β (IL IL-2 IL-

ABSTRACT The construction sector plays a fundamental role in social development, but is responsible for the consumption of the world’s natural and energy resources. Therefore, research seeks to incorporate waste into the production of materials, aligning with global goals for reducing CO2 emissions, disposal in landfills and resource extraction. Among industrial waste, waste from the glass cutting process (GCW) stands out, little explored in the literature and with significant rates of disposal in landfills. Therefore, this research aims to evaluate the properties of mortars incorporating GCW, as a partial replacement for Portland cement and aggregate, through a comprehensive investigation of the properties of the material produced. The materials that make up the mixtures and mortars were characterized in accordance with regulatory requirements. The data obtained were analyzed using the analysis of variance (ANOVA) methodology and Tukey test. The results showed that the GCW influenced the consistency index, the specific gravity and the tensile bond strength of the mortars, reducing water absorption, capillary absorption and shrinkage. As for compressive strength, it was observed that up to 10% by GCW, replacing cement, does not compromise this property, with a relative increase in strength when replacing sand. As for durability, there was an improvement in this property. It is concluded that the use of GCW, in partial replacement of Portland cement and fine aggregate, in the production of mortars is a technical alternative, as it presented performance that enables its use, and meets the principles of sustainable development, which present capable alternatives to contribute to saving energy and natural resources. development worlds world s resources Therefore CO emissions extraction (GCW out aggregate produced requirements ANOVA (ANOVA test index shrinkage 10 property sand durability alternative 1

RESUMO O setor da construção civil desempenha um papel fundamental no desenvolvimento social, mas é responsável pelo consumo de recursos naturais e energéticos do mundo. Portanto, as pesquisas buscam incorporar resíduos na produção de materiais, alinhando-se com metas globais de redução das emissões de CO2, descarte em aterros sanitários e extração dos recursos. Entre os resíduos industrias, destaca-se o resíduo proveniente do processo de lapidação do vidro (RLV), pouco explorado na literatura e com taxas significativas de descarte em aterros. Assim, esta pesquisa tem como objetivo avaliar as propriedades de argamassas com incorporação de RLV, em substituição parcial ao cimento Portland e ao agregado, por meio de uma investigação abrangente das propriedades do material produzido. Os materiais componentes das misturas e as argamassas foram caracterizados de acordo com as prescrições normativas. Os dados obtidos foram analisados por meio da metodologia de análise de variância (ANOVA) e teste de Tukey. Os resultados mostraram que o RLV influenciou no índice de consistência, na massa específica real e na aderência à tração das argamassas, reduziu a absorção de água, absorção por capilaridade e retração. Quanto à resistência à compressão, observou-se que até 10% pelo RLV, em substituição ao cimento, não compromete esta propriedade, havendo aumento relativo de resistência, quando em substituição à areia. Já para a durabilidade, houve uma melhoria nesta propriedade. Conclui-se que a utilização de RLV, em substituição parcial ao cimento Portland e ao agregado miúdo, na produção de argamassas é uma alternativa técnica, pois apresentou desempenho que possibilita seu uso, e atende aos princípios do desenvolvimento sustentável, os quais apresentam alternativas capazes de contribuir para a economia de energia e recursos naturais. social mundo Portanto alinhandose alinhando se CO2 CO industrias destacase destaca , (RLV) Assim produzido normativas ANOVA (ANOVA Tukey consistência água retração compressão observouse observou 10 propriedade areia durabilidade Concluise Conclui miúdo técnica uso sustentável (RLV 1

Abstract This study aimed to investigate the antioxidant and anti-inflammatory properties of quercetin on the cellular components of the Enteric Nervous System in the ileum of rats with arthritis. Rats were distributed into five groups: control (C), arthritic (AIA), arthritic treated with ibuprofen (AI), arthritic treated with quercetin (AQ) and arthritic treated with both ibuprofen and quercetin (AIQ). The ileum was processed for immunohistochemical techniques for HuC/D, calcitonin gene-related peptide, and vasoactive intestinal polypeptide. Measurements in histological sections, chemiluminescence assays, and total antioxidant capacity were also performed. Rheumatoid arthritis resulted in a decrease in neuronal density, yet neuroplasticity mechanisms were evident through observed changes in varicosities size and neuronal area compared to the control group. Reduced paw edema and neuroprotective effects were predominantly noted in both plexuses, as evidenced by the increased density preservation of HuC/D-IR neurons in the AIQ group. The increase of lipoperoxidation levels and paw edema volume in the AQ group was observed compared to the arthritic, whereas the AIQ group mainly showed similar results to those observed in the control. The enteropathy associated with arthritis proved to be significant in the field of gastroenterology, and the combination of quercetin and ibuprofen demonstrated promising anti-inflammatory and neuroprotective effects. antiinflammatory anti inflammatory groups C, C , (C) AIA, AIA (AIA) AI, AI (AI) (AQ AIQ. . (AIQ) HuCD HuC D HuC/D generelated gene related peptide polypeptide sections assays performed plexuses HuC/DIR HuCDIR IR gastroenterology (C (AIA (AI (AIQ DIR

ABSTRACT HIV infection is a chameleon, mimicking several diseases. Herein, we report a previously healthy 39-year-old woman who, over 2 months, developed arthritis, weight loss, and confluent multiple mononeuropathy. Extensive laboratory investigation showed positive serology for HIV, with a CD4 count of 100 cells, and necrotizing vasculitis on a nerve biopsy not associated with CMV co-infection, allowing the diagnosis of polyarteritis nodosa-like vasculitis in an HIV-infected patient. Apart from the infection, HIV-related autoimmunity can affect any organ and contribute to the complexity of the clinical presentation of HIV infection. chameleon diseases Herein 39yearold yearold 39 year old who months arthritis loss mononeuropathy CD 10 cells coinfection, coinfection co co-infection nodosalike nodosa like HIVinfected infected patient HIVrelated related 3 1

ABSTRACT Purpose Present the step of evidence of validity based on the responses to procedures of the MMBGR Protocol Infants and Preschoolers: Instructional and Orofacial Myofunctional Clinical History. Methods Study developed according to phonoaudiologic tests validations recommendations. Validity analysis performed based on the process of instrument response. Ten speech therapists, that work on phonoaudiology clinic and/or orofacial myofunctional research on the population with age between 6 to 71 months, participated and applied the MMBGR Protocol Infants and Preschoolers: Instructional and Orofacial Myofunctional Clinical History with those responsible for the children. The speech therapists appraised the instrument applicability via Google®️ electronic forms, containing dichotic and/or multiple-choice questions, and likert scale with space to justify negative answers. The data was tabulated on Microsoft Excel 2016®️ worksheets and analyzed by the content validity index (CVI). The software R Core Team 2022 (Versão 4.2.2) was used. Results All items from the MMBGR Protocol Infants and Preschoolers: Instructional and Orofacial Myofunctional Clinical History were valid when applied to real contexts. Orofacial Myofunctional Clinic history protocol- IVC 100% in terms of ease of application and filling and usage in professional practice; IVC 90% in terms of usefulness for phonoaudiology clinic. The instructional got IVC 80% in terms of clinic usefulness and 70% regarding to the prior reading necessity to fill the MMBGR Protocol Infants and Preschoolers. Conclusion The Instrucional and Orofacial Myofunctional Clinical History, in the MMBGR Protocol Infants and Preschoolers had its validity proven based on the processes of responses to the usage on phonoaudiology clinic. recommendations response andor or 7 months children Google Google® forms multiplechoice multiple choice questions answers 2016 2016® CVI. CVI . (CVI) 202 Versão 4.2.2 422 4 2 used contexts protocol 100 practice 90 80 70 201 (CVI 20 4.2. 42 10 9 8 4.2 1 4.

RESUMO Objetivo Apresentar a etapa da evidência de validade baseada nos processos de respostas do Protocolo MMBGR Lactentes e Pré-escolares: Instrutivo e História Clínica Miofuncional Orofacial. Método Estudo desenvolvido conforme recomendações para validação de testes em Fonoaudiologia. Realizada análise da validade baseada nos processos de resposta do instrumento. Participaram dez fonoaudiólogos, que atuam em clínica e/ou pesquisa da Motricidade Orofacial com população entre 6 e 71 meses de idade, que aplicaram o Protocolo MMBGR Lactentes e Pré-escolares: Instrutivo e História Clínica Miofuncional Orofacial junto aos responsáveis pelas crianças. Os fonoaudiólogos emitiram apreciação sobre aplicabilidade do instrumento via formulário eletrônico do Google®, contendo questões dicóticas e/ou múltipla escolha, e escala likert com espaço para justificar respostas negativas. Os dados foram tabulados em planilhas Microsoft Excel 2016® e analisados pelo Índice de Validade de Conteúdo (IVC). Utilizado software R Core Team 2022 (Versão 4.2.2). Resultados Todos os itens do Protocolo MMBGR Lactentes e Pré-escolares: Instrutivo e História Clínica Miofuncional Orofacial foram válidos na aplicação em contexto real. Protocolo de História Clínica Miofuncional Orofacial - IVC 100% quanto à facilidade de aplicação e preenchimento, e uso na prática profissional; e IVC 90% quanto à utilidade para clínica fonoaudiológica. O Instrutivo obteve IVC 80% quanto à utilidade e 70% referente à necessidade de leitura prévia para preenchimento do Protocolo MMBGR Lactentes e Pré-escolares. Conclusão O Instrutivo e o Protocolo História Clínica Miofuncional Orofacial, pertencentes ao protocolo MMBGR – Lactentes e Pré-escolares tiveram comprovada validade baseada nos processos de resposta, para uso na clínica fonoaudiológica. Préescolares Pré escolares Fonoaudiologia eou ou 7 idade crianças Google Google® escolha negativas 2016 IVC. . (IVC) 202 Versão 4.2.2. 422 4.2.2 4 2 4.2.2) real 100 profissional 90 fonoaudiológica 80 70 Préescolares. escolares. 201 (IVC 20 42 4.2. 10 9 8 4.2 1 4.

ABSTRACT Objective: To grasp the meaning of perinatal palliative care for the multidisciplinary team. Methods: This is a qualitative study guided by content analysis. The study included 56 health professionals working in maternal and child units of a public university hospital. A semi-structured interview was conducted, which was recorded and subsequently fully transcribed. The collection took place from June 2018 to May 2019. Data were entered and exported to Atlas ti: The Qualitative Date Analysis & Research Software, version 23.1.1.0. Results: Four thematic categories emerged from the data analysis: palliative care and eligible public in the view of professionals; communication between family and team in decision-making; assistance in palliative care; humanized care. Conclusions: The professionals think of palliative care in Perinatology in a similar way and perceive the difficulties of communication with the family and decision-making. They agree that it is necessary to provide greater support to the family, and to provide comfort measures, either for the non-viable fetus or for the baby eligible for palliative care. Objective Methods analysis 5 hospital semistructured semi structured conducted transcribed 201 2019 ti Software 23110 23 1 0 23.1.1.0 Results decisionmaking decision making decision-making Conclusions decisionmaking. making. measures nonviable non viable 20 2311 2 23.1.1. 231 23.1.1 23.1. 23.1 23.

RESUMO Objetivo: Apreender o significado dos cuidados paliativos perinatais para a equipe multiprofissional. Métodos: Trata-se de um estudo qualitativo orientado pela análise de conteúdo. Participaram do estudo 56 profissionais de saúde atuantes em unidades materno-infantis de um hospital universitário público. Foi realizada uma entrevista semiestruturada, a qual foi gravada e posteriormente transcrita na íntegra. A coleta ocorreu no período de junho de 2018 a maio de 2019. Os dados foram digitados e exportados para o software Atlas ti: The Qualitative Date Analysis & Research Software, versão 23.1.1.0. Resultados: Quatro categorias temáticas emergiram da análise dos dados: cuidados paliativos e público elegível na visão dos profissionais; comunicação entre família e equipe na tomada de decisão; assistência no cuidado paliativo; cuidado humanizado. Conclusões: Os profissionais significam os cuidados paliativos em perinatologia de modo semelhante e percebem as dificuldades de comunicação com a família e a tomada de decisão. Concordam que é necessário fornecer maior apoio à família e proporcionar medidas de conforto, seja para o feto inviável, seja para o bebê elegível para cuidados paliativos. Objetivo multiprofissional Métodos Tratase Trata se conteúdo 5 maternoinfantis materno infantis semiestruturada íntegra 201 2019 ti Software 23110 23 1 0 23.1.1.0 Resultados decisão paliativo humanizado Conclusões conforto inviável 20 2311 2 23.1.1. 231 23.1.1 23.1. 23.1 23.