Resumen El análisis de los ácidos orgánicos urinarios juega un papel crucial en el diagnóstico y seguimiento de pacientes con trastornos metabólicos congénitos. La falta de datos completos, las variaciones en los hábitos alimentarios entre países y el aumento del consumo de alimentos procesados subrayan la necesidad de realizar investigaciones actualizadas. Con el fin de establecer los intervalos de confianza y medianas de ácidos orgánicos urinarios se evaluaron mediante cromatografía gaseosa acoplada a espectrometría de masas, 125 muestras de orina de pacientes sanos, con edades comprendidas entre 2 días y 13 años. Los resultados fueron analizados teniendo en cuenta el grupo etario, y evidenciaron que las concentraciones de la mayoría de los ácidos orgánicos urinarios varían de acuerdo a la edad, lo que enfatiza la importancia de los valores de referencia emparejados con la edad para interpretar los datos de los pacientes. Existen pocos informes en esta área; sin embargo, la comparación de estos resultados con los valores de referencia informados por otros trabajos muestra una concordancia razonable y las pocas disparidades podrían atribuirse a factores genéticos o influencias dietéticas. Se presentan resultados e interpretaciones de niños previamente diagnosticados con trastornos metabólicos y otras afecciones, lo que confirma la confiabilidad de nuestros datos y métodos analíticos. Este estudio proporciona datos de referencia esenciales para los profesionales clínicos, destaca la importancia de los valores de referencia específicos de la edad para diagnosticar y tratar con precisión a pacientes con trastornos metabólicos y sirve como recurso fundamental para futuras investigaciones en este campo.

Resumo A análise dos ácidos orgânicos urinários desempenha um papel crucial no diagnóstico e monitoramento de pacientes com distúrbios metabólicos congênitos. A falta de dados completos, as variações nos hábitos alimentares entre países e o aumento do consumo de alimentos processados destacam a necessidade de realizar pesquisas atualizadas. Para estabelecer os intervalos de confiança e medianas de ácidos orgânicos urinários, 125 amostras de urina de pacientes saudáveis, com idades entre 2 dias e 13 anos, foram avaliadas por cromatografia gasosa acoplada à espectrometria de massa. Os resultados foram analisados levando em consideração o grupo etário, evidenciando que as concentrações da maioria dos ácidos orgânicos urinários variam de acordo com a idade, o que destaca a importância dos valores de referência pareados com a idade para interpretar os dados dos pacientes. Há poucos relatos nesta área; no entanto, a comparação destes resultados com os valores de referência informados por outros trabalhos demonstra uma concordância razoável, e as poucas disparidades poderiam ser atribuídas a fatores genéticos ou influências dietéticas. São apresentados resultados e interpretações de crianças previamente diagnosticadas com distúrbios metabólicos e outras condições, o que confirma a confiabilidade de nossos dados e métodos analíticos. Este estudo fornece dados de referência essenciais para profissionais clínicos, enfatizando a importância dos valores de referência específicos da idade para diagnosticar e tratar com precisão pacientes com distúrbios metabólicos, e serve como recurso fundamental para futuras pesquisas nesse campo.

Abstract Analysis of urinary organic acids plays a crucial role in the diagnosis and monitoring of patients with congenital metabolic disorders. The lack of complete data, variations in dietary habits between countries, and increasing consumption of processed foods highlight the need for up-to-date research. In order to establish the confidence intervals and medians of urinary organic acids, 125 urine samples from healthy patients, aged between 2 days and 13 years, were evaluated by gas chromatography coupled to mass spectrometry. The results were analysed taking into account the age group, showing that the concentrations of most urinary organic acids vary according to age, which emphasises the importance of paired age reference values to interpret patient data. There are few reports in this area; however, comparing our results with those reference values reported by other papers demonstrates reasonable agreement, and minor disparities could be attributed to genetic factors or dietary influences. Results and interpretations from children previously diagnosed with metabolic disorders and other conditions are presented, confirming the reliability of our data and analytical methods. This study provides essential reference data for clinicians, highlighting the importance of age-specific reference values to accurately diagnose and treat patients with metabolic disorders and serves as a critical resource for future research in this field.

RESUMO Objetivo: Descrever o primeiro caso conhecido de bertielose humana no Paraná, Brasil. Descrição do caso: Criança de seis anos do sexo masculino, residente no Paraná, Brasil, apresentava dor abdominal inespecífica intermitente e distensão abdominal, associadas à expulsão de helmintos vivos em suas fezes havia sete meses. Tinha um histórico de interação com macacos em uma ilha. Sua primeira análise de fezes foi inconclusiva, com hipótese inicial de uma Taenia atípica. No entanto, após pesquisas adicionais, o parasitologista identificou proglótides gravídicas de Bertiella sp. O paciente foi inicialmente tratado com uma dosagem desconhecida de albendazol e nitazoxanida, pois se acreditava que havia sido infectado por Taenia sp. Diante da persistência dos sintomas, foi prescrito praziquantel 10 mg/kg, sem mais eliminação de proglótides. Comentários: A bertielose humana é uma zoonose rara, com menos de cem casos relatados. No entanto, é uma causa de dor abdominal crônica e deve ser mantida como diagnóstico diferencial, principalmente nos casos que relatam expulsão recorrente de helmintos nas fezes e que são refratários ao tratamento com albendazol. Objetivo Paraná Brasil masculino meses ilha inconclusiva atípica entanto adicionais sp nitazoxanida sintomas 1 mgkg mg kg mg/kg Comentários rara relatados diferencial

ABSTRACT Objective: To describe the first known case of human Bertiellosis in Paraná (Brazil). Case description: A 6-year-old male residing in the Brazilian state of Paraná was suffering from intermittent nonspecific abdominal pain and abdominal distension, associated with expulsion of live tapeworms in his feces for 7 months. He had a history of interaction with monkeys on an island. His first feces analysis was inconclusive, with an initial hypothesis of an atypical Taenia. However, after additional research, the parasitologist identified pregnant proglottids of Bertiella sp. The patient was initially treated with an unknown dosage of albendazole and nitazoxanide, as it was believed he had been infected with Taenia sp. Since the symptoms persisted, praziquantel 10 mg/kg was prescribed without further proglottids elimination. Comments: Human Bertiellosis is a rare zoonosis, with less than one hundred cases reported. However, it is a cause of chronic abdominal pain and should be kept as a differential diagnosis, especially in cases reporting recurrent tapeworm expulsion in feces and refractory treatment with albendazole. Objective Brazil. Brazil . (Brazil) description 6yearold yearold 6 year old distension months island inconclusive However research sp nitazoxanide persisted 1 mgkg mg kg elimination Comments zoonosis reported diagnosis (Brazil

RESUMO Este artigo visa mapear como o campo das capacidades dinâmicas se desenvolveu desde os artigos seminais de Teece et al. (1997) e Eisenhardt e Martin (2000). Identificamos 10.838 artigos e usamos o algoritmo de alocação latente de Dirichlet para modelagem de tópicos. Realizamos dois tipos distintos de análise: a primeira foi baseada na temporalidade e características dos estudos, enquanto a segunda foi interpretativa e baseada na rede de conceitos teóricos estabelecidos. Os resultados indicam que há uma aproximação entre as ideias dos dois artigos seminais, que inicialmente eram vistas como opostas. Observamos um movimento de valorização das questões relacionais, seguindo um caminho de construção coletiva e de menor atenção à empresa isoladamente. A contribuição do artigo está em apontar a consolidação do campo das capacidades dinâmicas e suas tendências, ampliar a compreensão dos principais elementos envolvidos no desenvolvimento dessas capacidades e definir seus conceitos originais e atuais, bem como oferecer uma possível agenda para futuras pesquisas. al 1997 (1997 2000. 2000 . (2000) 10838 10 838 10.83 tópicos análise estudos estabelecidos opostas relacionais isoladamente tendências atuais pesquisas 199 (199 200 (2000 1083 1 83 10.8 19 (19 20 (200 108 8 10. (1 2 (20 ( (2

ABSTRACT This paper aims to map out how the field of dynamic capabilities has developed since the seminal studies by Teece et al. (1997) and Eisenhardt and Martin (2000). We identified 10,838 papers and used the Latent Dirichlet Allocation algorithm for topic modeling. We conducted two analyses: the first was based on the temporality and characteristics of the studies; the second was interpretative and based on the network of theoretical concepts. Results indicate an approximation between the ideas of the two seminal studies, which were initially viewed as opposite. We observe a movement to value relational issues, following a collective construction path, and paying less attention to the firm itself. Overall, we were able to understand the consolidation of the dynamic capabilities field; understand the core elements involved in the development of dynamic capabilities; set out the original and current concepts of dynamic capabilities; and indicate tendencies and a possible future research agenda. al 1997 (1997 2000. 2000 . (2000) 10838 10 838 10,83 modeling analyses opposite issues path itself Overall agenda 199 (199 200 (2000 1083 1 83 10,8 19 (19 20 (200 108 8 10, (1 2 (20 ( (2

RESUMEN Este artículo pretende mapear cómo se ha desarrollado el campo de las capacidades dinámicas desde los artículos de Teece et al. (1997) y Eisenhardt y Martin (2000). Identificamos 10.838 artículos y utilizamos el algoritmo de asignación latente de Dirichlet para el modelado de temas. Realizamos dos tipos de análisis: el primero, basado en la temporalidad y características de los estudios; y el segundo, en la red de conceptos teóricos establecidos. Los resultados indican que existe aproximación entre las ideas de dos artículos seminales que inicialmente se veían como opuestas. Observamos un movimiento hacia la valoración de las cuestiones relacionales, siguiendo un camino de construcción colectiva y prestando menos atención a la empresa de forma aislada. El artículo contribuye a: señalar la consolidación del campo de las capacidades dinámicas; comprender los principales elementos involucrados en el desarrollo de las capacidades dinámicas; definir sus conceptos originales y actuales; e indicar las tendencias en el campo y una posible agenda para futuras investigaciones. al 1997 (1997 2000. 2000 . (2000) 10838 10 838 10.83 temas análisis primero estudios segundo establecidos opuestas relacionales aislada actuales investigaciones 199 (199 200 (2000 1083 1 83 10.8 19 (19 20 (200 108 8 10. (1 2 (20 ( (2

Resumo Objetivos Os efeitos da pandemia de COVID-19 no comportamento suicida continuam sendo tema de estudos. Hipotetiza-se que a pandemia pode ter contribuído para a ideação suicida ao intensificar fatores de risco psicossociais. Nosso objetivo foi investigar tais fatores correlatos no Brasil. Método Este estudo realizou uma coleta de dados online e transversal, englobando 448 participantes adultos. Utilizaram-se questionários sociodemográficos e o Self-Reporting Questionnaire, empregando-se regressão logística binária para identificação de preditores. Resultados A prevalência de ideação suicida foi de 22,3%. Os resultados apontam que pessoas autoidentificadas como negros e pardos (OR = 2,42), que faziam parte do grupo de risco para COVID-19 (OR = 2,41), e que reportaram mais sintomas psicológicos (OR = 1,50) tiveram maior chance de apresentar ideação suicida. Conclusão Políticas públicas de prevenção do comportamento suicida e promoção de saúde mental nos grupos mais vulneráveis podem ser necessárias para além do contexto pandêmico, sobretudo entre a população negra. COVID19 COVID 19 COVID-1 estudos Hipotetizase Hipotetiza se psicossociais Brasil transversal 44 adultos Utilizaramse Utilizaram SelfReporting Self Reporting Questionnaire empregandose empregando preditores 223 22 3 22,3% OR 2,42, 242 2,42 , 2 42 2,42) 2,41, 241 2,41 41 2,41) 1,50 150 1 50 pandêmico negra COVID1 COVID- 4 22,3 24 2,4 1,5 15 5 22, 2, 1,

Abstract Objective The effects of the COVID-19 pandemic on suicidal behavior are still the subject of studies. It is hypothesized that the pandemic may have contributed to the development of suicidal ideation by intensifying psychosocial risk factors. Our objective was to investigate such correlated factors in Brazil. Method The study used an online and cross-sectional survey encompassing 448 adult participants. Sociodemographic questionnaires and the Self-Reporting Questionnaire were used, and binary logistic regression was employed to identify predictors. Results The prevalence of suicidal ideation was 22.3%. The results indicate that people who self-identified as black and brown (OR = 2.42), who were part of the risk group for COVID-19 (OR = 2.41), and who reported more psychological symptoms (OR = 1.50) were more likely to have suicidal ideation. Conclusion Public policies to prevent suicidal behavior and promote mental health in the most vulnerable groups might be needed beyond the pandemic context, especially among the black population. COVID19 COVID 19 COVID-1 studies Brazil crosssectional cross sectional 44 participants SelfReporting Self Reporting predictors 223 22 3 22.3% selfidentified self identified OR 2.42, 242 2.42 , 2 42 2.42) 2.41, 241 2.41 41 2.41) 1.50 150 1 50 context population COVID1 COVID- 4 22.3 24 2.4 1.5 15 5 22. 2. 1.

Abstract Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions affecting the digestive tract. This study examines 188 IBD patients in a private healthcare service in Canoas/RS, Brazil, aiming to understand their clinical profiles. Most patients were young adults, primarily white, with more women affected. Both CD and UC patients commonly experienced diarrhea, but blood in stools was more prevalent in UC. CD mostly affected the small intestine, while UC involved the rectum or extended through the colon. The diagnosis was prompt, with most CD cases diagnosed within six months and UC cases within twelve months of symptom onset. Family histories of IBD and colorectal cancer were observed, particularly in CD patients. Extraintestinal manifestations were more frequent in CD. Elevated CRP levels were common in CD, while FC values were elevated in both groups. Treatment approaches differed, with 5-ASA primarily used in UC and immunomodulators in CD. Biological therapy was less commonly employed initially. This study aligns with global IBD trends in demographics, symptoms, and disease locations. Early diagnosis likely results from specialized private healthcare, emphasizing the importance of timely diagnosis and tailored treatment. IBD, , (IBD) Crohns Crohn s (CD UC, (UC) tract 18 CanoasRS Canoas RS Canoas/RS Brazil profiles adults white diarrhea intestine colon prompt onset observed groups differed 5ASA ASA 5 initially demographics symptoms locations treatment (IBD (UC 1

Abstract Gluten-free products and non-alcoholic beverages have become popular global trends. This study assessed strategies for producing low-alcoholic and low or gluten-free beers. Barley malts were fermented by Saccharomyces cerevisiae or Saccharomycodes ludwigii, and commercial endopeptidase was used to reduce gluten. S. cerevisiae is the most used yeast in alcoholic beer, so vacuum evaporation was used to reduce values of ethanol. S. ludwigii produces less alcohol, however, there was no data reported it would ferment on a semi-industrial scale. The physiochemical parameters in rice malt beers were similar to both yeasts. However, the parameters found differed for beer with barley malt mainly ethanol values, confirming the fermentative difference by tested strains. Volatile composition was evaluated and analyzed by multivariate analysis. The beers proposed by different methodologies: S. cerevisiae with barley malt, peptidase, and evaporation exhibited aromas of floral and featuring beer and spice notes, among others; S. ludwigii fermentation with barley malt and peptidase showcased aromas rich in floral and fresh accents, among others; and, S. cerevisiae with malted rice exhibited notes evoking fruity notes reminiscent of roses and S. ludwigii using malted rice was associated with aromas featuring fruity attributes and emitting rancid notes, among others. Among all the strategies tested, the one using barley malt, enzyme, and S. cerevisiae proved results in terms of aromatic parameters, even with the final boiling process to remove the alcohol. Glutenfree Gluten free nonalcoholic non trends lowalcoholic glutenfree gluten S alcohol however semiindustrial semi industrial scale yeasts However strains analysis methodologies others accents enzyme

Abstract This study aimed to assess the cortisol, body and reproductive development of prepubertal Holstein and Holstein-Gir ¾ heifers at 27 months of age maintained in an integrated livestock-forest (ILF) system for 60 summer days compared to the monoculture system in full sun (FS). The ILF system promoted changes (P=0.02) in the cortisol levels of Holstein-Gir ¾ heifers and did not affect weight gain in any of the breed groups studied. Animals in ILF system presented a lower (P=0.006) vulvar development for the rima height parameter and similar for the vulva width parameter. The ovarian follicular population of Holstein-Gir ¾ heifers in the ILF system was lower (P=0.004); however, for the Holstein heifers, no statistical difference was found, and numbers were higher (P=0.08) in the ILF system. None of the other ovarian parameters studied had any changes, and we also found important racial differences. Weight gain (P=0.003), vulvar development (P<0.001), and mean follicular size (P=0.008) were higher in the Holstein-Gir ¾ animals. Based on such results, the effect of the ILF system at 27 months of age on stress and reproductive parameters in the Holstein breed is considered positive, although negative effects have been detected on reproductive parameters in the Holstein-Gir ¾ breed. HolsteinGir Gir 2 livestockforest livestock forest (ILF 6 FS. FS . (FS) P=0.02 P002 P 0 02 (P=0.02 P=0.006 P0006 006 (P=0.006 P=0.004 P0004 004 (P=0.004) however P=0.08 P008 08 (P=0.08 differences P=0.003, P0003 P=0.003 , 003 (P=0.003) P<0.001, P0001 P<0.001 001 (P<0.001) P=0.008 P0008 008 (P=0.008 animals results positive (FS P=0.0 P00 (P=0.0 P=0.00 P000 00 (P=0.00 (P=0.004 (P=0.003 P<0.00 (P<0.001 P=0. P0 (P=0. P<0.0 (P<0.00 P=0 (P=0 P<0. (P<0.0 P= (P= P<0 (P<0. (P P< (P<0 (P<

RESUMEN Se analizan los campos espaciales de la varianza del espectro de radiación de onda larga saliente (OLR, por su sigla en inglés) durante los meses del verano austral 1979-2016 en el sur de Brasil, para diferentes escalas de tiempo: sinóptica, submensual e intraestacional. Los campos de variabilidad difieren tanto en intensidad como en ubicación y resaltan los ciclos de convección dominantes en el área de estudio. La amplitud de la variabilidad submensual es mayor que la de las otras escalas en la región sudeste de Brasil, mientras que la escala sinóptica prevalece en la región sur. Las escalas mencionadas anteriormente muestran mayores amplitudes sobre el Océano Pacífico occidental donde la Oscilación Madden-Julian juega un papel importante, a lo largo de la Zona de Convergencia del Pacífico Sur y sobre las áreas de trayectoria de tormentas sobre el Océano Pacífico sur. También se analiza la influencia de la interacción espectral de OLR asociada con la ocurrencia de dos eventos de lluvia intensa en el sudeste de Brasil en los veranos de 2011 y 2014, cuando la Zona de Convergencia del Atlántico Sur (SACZ) estuvo activa en ambos eventos. Los resultados obtenidos sugieren que la interacción entre escalas espectrales de OLR tiene lugar de forma tal que fortalece la SACZ, ya que los patrones espaciales de la escala temporal de dos a ocho días (sinóptica), la escala temporal de 10 a 30 días (submensual) y la escala temporal de 30 a 60 días (intraestacional), se superponen en la región de estudio.

ABSTRACT Spatial fields of outgoing long wave radiation (OLR) spectrum variance of the 1979-2016 austral summer months in southern Brazil are analyzed on different timescales: synoptic, sub-monthly, and intra-seasonal. Variability fields differ both in intensity and location and highlight dominant convection cycles in the study area. The results show that the amplitude of sub-monthly variability is greater than that of the other scales in the southeastern region of Brazil, while the synoptic scale prevails in the southern region. The above-mentioned scales show greater amplitudes over the western Pacific Ocean where the Madden-Julian Oscillation plays an important role, along the South Pacific Convergence Zone, and over the storm track areas over the South Pacific Ocean. The influence of spectral OLR scale interaction is also analyzed, associated to the occurrence of two intense rainfall events over the southeastern Brazil in the austral summers of 2011 and 2014 when the South Atlantic Convergence Zone (SACZ) was active in both events. The results obtained suggest that spectral OLR scale interaction takes place in such way that it strengthens the SACZ, since the spatial pattern footprints of the two to eight-day timescale (synoptic), 10 to 30-day timescale (sub-monthly) and 30 to 60-day timescale (intra-seasonal) overlap in the study region.

Resumo: O objetivo foi estimar a prevalência do atraso nas três doses da vacina tetravalente (DTP+Hib) em crianças de 12 a 23 meses de idade, no Brasil, por meio dos dados da Pesquisa Nacional de Saúde (PNS) de 2013 e descrever o atraso em cada uma das doses segundo variáveis sociodemográficas, utilização de serviços e intervenções públicas de saúde. Foram utilizados dados da PNS, estudo transversal realizado em 2013. O desfecho foi o atraso pelo menos em uma das três doses da vacina tetravalente. Considerou-se como atraso a dose recebida pelo menos 30 dias após a data preconizada, segundo informação da caderneta de vacinação. A prevalência do atraso foi descrita segundo variáveis sociodemográficas e utilização de serviços de saúde. Realizou-se análise descritiva obtendo-se frequências absolutas e relativas e seus respectivos intervalos de 95% de confiança. Das 2.016 crianças com informações coletadas, 1.843 foram analisadas. A prevalência de atraso de pelo menos uma dose da vacina foi de 44%. Observou-se atraso de 14,8% na primeira, 28,8% na segunda e 45,4% na terceira dose, sendo que 10% das crianças tiveram atraso nas três doses. Maiores prevalências de atraso foram encontradas em crianças do sexo masculino, de cor da pele parda, pertencentes ao quintil mais pobre de riqueza, moradores da zona rural e da Região Norte do Brasil. Evidenciou-se alta prevalência de atraso na vacina tetravalente (DTP+Hib) em crianças de 12 a 23 meses do Brasil, sendo maior na terceira dose.

Abstract: The study aimed to estimate the prevalence of delay in the three doses of quadrivalent vaccine (DTP+Hib) in children 12 to 23 months of age in Brazil, based on data from the Brazilian National Health Survey (PNS) of 2013 and to analyze the delay in each of the doses according to sociodemographic variables and use of health services and public health interventions. The data are from the PNS a cross-sectional study performed in 2013. The outcome was delay in at least one of the three doses of the quadrivalent vaccine. Delay was defined as a dose received at least 30 days after the recommended date according to information on the child’s vaccination card. Prevalence of delay was analyzed according to sociodemographic variables and use of health services. A descriptive analysis was performed to obtain absolute and relative frequencies and their respective 95% confidence intervals. Of the 2,016 children with information collected, 1,843 were analyzed. The prevalence of delay in at least one dose of the vaccine was 44%. There was a delay of 14.8% in the first dose, 28.8% in the second, and 45.4% in the third, and 10% of the children had delays in all three doses. Higher prevalence of delay was associated with male gender, brown skin color, the poorest income quintile, and residence in rural areas and the North of Brazil. The study revealed high prevalence of delay with the quadrivalent vaccine (DTP+Hib) in children 12 to 23 months of age in Brazil, with the highest delay in the third dose.

Resumen: El objetivo fue estimar la prevalencia del atraso en las tres dosis de la vacuna tetravalente (DTP+Hib) en niños de 12 a 23 meses de edad, en Brasil, mediante los datos de la Encuesta Nacional de Salud (PNS) de 2013 y describir el retraso en cada una de las dosis, según variables sociodemográficas, utilización de servicios e intervenciones públicas de salud. Se trata de un estudio transversal, realizado en 2013, con datos de la PNS. El resultado fue el retraso por lo menos en una de las tres dosis de la vacuna tetravalente. Se consideró como un atraso la dosis recibida por lo menos 30 días tras la fecha prefijada, según la información de la cartilla de vacunación. La prevalencia del atraso fue descrita según variables sociodemográficas y utilización de servicios de salud. Se realizó un análisis descriptivo, obteniéndose frecuencias absolutas y relativas, así como sus respectivos intervalos de 95% de confianza. De los 2016 niños con información recogida, se analizaron 1843. La prevalencia de atraso de por lo menos una dosis de la vacuna fue de un 44%. Se observó un retraso de 14,8% en la primera, un 28,8% en la segunda y un 45,4% en la tercera dosis, siendo que un 10% de los niños sufrieron atraso en las tres dosis. Las mayores prevalencias de atraso se encontraron en niños de sexo masculino, mestizos, pertenecientes al quintil más pobre de riqueza, habitantes de la zona rural y de la Región Norte de Brasil. Se evidenció una alta prevalencia de atraso en la vacuna tetravalente (DTP+Hib) en niños de 12 a 23 meses de Brasil, siendo mayor en la tercera dosis.

Resumo: O objetivo foi estimar a prevalência do atraso nas três doses da vacina tetravalente (DTP+Hib) em crianças de 12 a 23 meses de idade, no Brasil, por meio dos dados da Pesquisa Nacional de Saúde (PNS) de 2013 e descrever o atraso em cada uma das doses segundo variáveis sociodemográficas, utilização de serviços e intervenções públicas de saúde. Foram utilizados dados da PNS, estudo transversal realizado em 2013. O desfecho foi o atraso pelo menos em uma das três doses da vacina tetravalente. Considerou-se como atraso a dose recebida pelo menos 30 dias após a data preconizada, segundo informação da caderneta de vacinação. A prevalência do atraso foi descrita segundo variáveis sociodemográficas e utilização de serviços de saúde. Realizou-se análise descritiva obtendo-se frequências absolutas e relativas e seus respectivos intervalos de 95% de confiança. Das 2.016 crianças com informações coletadas, 1.843 foram analisadas. A prevalência de atraso de pelo menos uma dose da vacina foi de 44%. Observou-se atraso de 14,8% na primeira, 28,8% na segunda e 45,4% na terceira dose, sendo que 10% das crianças tiveram atraso nas três doses. Maiores prevalências de atraso foram encontradas em crianças do sexo masculino, de cor da pele parda, pertencentes ao quintil mais pobre de riqueza, moradores da zona rural e da Região Norte do Brasil. Evidenciou-se alta prevalência de atraso na vacina tetravalente (DTP+Hib) em crianças de 12 a 23 meses do Brasil, sendo maior na terceira dose.

Abstract: The study aimed to estimate the prevalence of delay in the three doses of quadrivalent vaccine (DTP+Hib) in children 12 to 23 months of age in Brazil, based on data from the Brazilian National Health Survey (PNS) of 2013 and to analyze the delay in each of the doses according to sociodemographic variables and use of health services and public health interventions. The data are from the PNS a cross-sectional study performed in 2013. The outcome was delay in at least one of the three doses of the quadrivalent vaccine. Delay was defined as a dose received at least 30 days after the recommended date according to information on the child’s vaccination card. Prevalence of delay was analyzed according to sociodemographic variables and use of health services. A descriptive analysis was performed to obtain absolute and relative frequencies and their respective 95% confidence intervals. Of the 2,016 children with information collected, 1,843 were analyzed. The prevalence of delay in at least one dose of the vaccine was 44%. There was a delay of 14.8% in the first dose, 28.8% in the second, and 45.4% in the third, and 10% of the children had delays in all three doses. Higher prevalence of delay was associated with male gender, brown skin color, the poorest income quintile, and residence in rural areas and the North of Brazil. The study revealed high prevalence of delay with the quadrivalent vaccine (DTP+Hib) in children 12 to 23 months of age in Brazil, with the highest delay in the third dose.

Resumen: El objetivo fue estimar la prevalencia del atraso en las tres dosis de la vacuna tetravalente (DTP+Hib) en niños de 12 a 23 meses de edad, en Brasil, mediante los datos de la Encuesta Nacional de Salud (PNS) de 2013 y describir el retraso en cada una de las dosis, según variables sociodemográficas, utilización de servicios e intervenciones públicas de salud. Se trata de un estudio transversal, realizado en 2013, con datos de la PNS. El resultado fue el retraso por lo menos en una de las tres dosis de la vacuna tetravalente. Se consideró como un atraso la dosis recibida por lo menos 30 días tras la fecha prefijada, según la información de la cartilla de vacunación. La prevalencia del atraso fue descrita según variables sociodemográficas y utilización de servicios de salud. Se realizó un análisis descriptivo, obteniéndose frecuencias absolutas y relativas, así como sus respectivos intervalos de 95% de confianza. De los 2016 niños con información recogida, se analizaron 1843. La prevalencia de atraso de por lo menos una dosis de la vacuna fue de un 44%. Se observó un retraso de 14,8% en la primera, un 28,8% en la segunda y un 45,4% en la tercera dosis, siendo que un 10% de los niños sufrieron atraso en las tres dosis. Las mayores prevalencias de atraso se encontraron en niños de sexo masculino, mestizos, pertenecientes al quintil más pobre de riqueza, habitantes de la zona rural y de la Región Norte de Brasil. Se evidenció una alta prevalencia de atraso en la vacuna tetravalente (DTP+Hib) en niños de 12 a 23 meses de Brasil, siendo mayor en la tercera dosis.

Abstract Objective The objective of this study was to translate and adapt the National Institute of Mental Health Life Chart Method – Self/Prospective (NIMH-LCM-S/P™) instrument for self-monitoring of mood into Brazilian Portuguese and provide evidence of content validity. Additionally, a user guide was prepared for the instrument and evaluated by mental health professionals. Methods The study was divided into two stages – Stage 1: Translation and cross-cultural adaptation and Stage 2: Determination of content validity index (CVI) scores. The translation and cross-cultural adaptation process involved 37 participants between translators, experts, target population, and evaluators. Results The CVI was evaluated by 15 mental health professionals. 11 (78.57%) of the items evaluated attained the maximum CVI score of 1.00, which constitutes the highest level of content validity, and no changes were suggested by participants. Only one of the items evaluated had a CVI score lower than 0.80. Conclusion The final translated and adapted version of the NIMH-LCM-S/P™ and its user guide were evaluated by the target population and the mental health professionals. Both groups displayed satisfactory comprehension levels, suggesting there is potential for using this instrument in clinical practice to assess therapeutic interventions in Brazilian settings.

Abstract In this paper, we propose an interdisciplinary approach to the analysis and translation of Calcidius’De silua, through the combination of discursive analysis from the Systemic Functional Linguistics and the conceptual analysis of the philosophical and doctrinal elements of the work. Our aim is to establish the discursive configuration ofDe siluaas an original reading of Plato’s work and of the philosophical tradition in which the author inscribes himself. We begin with a general introduction of our approach and, in a second part, we analyze specifically the first paragraph as an example of the results that we have reached with our methodology, through which we will examine, in future works, the rest of the treatise.

Resumen En el presente trabajo proponemos un acercamiento al análisis y la traducción del tratado De silua (Sobre la materia) de Calcidio, sección final de su Comentario al Timeo, utilizando un enfoque interdisciplinario que combina el análisis discursivo sobre la base de la lingüística sistémico-funcional, y el análisis conceptual que lidia con los elementos doctrinales filosóficos presentes en la obra de Calcidio. En este marco, buscamos caracterizar la configuración discursiva del De silua como operación original de Calcidio en su lectura de Platón y de la tradición filosófica en la que se inscribe. En una primera parte, nos ocupamos de hacer una presentación general de nuestro abordaje y, en una segunda parte, analizamos específicamente el primer parágrafo, como una primera muestra de los resultados alcanzados a partir de la metodología propuesta, mediante la cual abordaremos, en trabajos sucesivos, el resto del tratado.

Abstract Objective The objective of this study was to translate and adapt the National Institute of Mental Health Life Chart Method – Self/Prospective (NIMH-LCM-S/P™) instrument for self-monitoring of mood into Brazilian Portuguese and provide evidence of content validity. Additionally, a user guide was prepared for the instrument and evaluated by mental health professionals. Methods The study was divided into two stages – Stage 1: Translation and cross-cultural adaptation and Stage 2: Determination of content validity index (CVI) scores. The translation and cross-cultural adaptation process involved 37 participants between translators, experts, target population, and evaluators. Results The CVI was evaluated by 15 mental health professionals. 11 (78.57%) of the items evaluated attained the maximum CVI score of 1.00, which constitutes the highest level of content validity, and no changes were suggested by participants. Only one of the items evaluated had a CVI score lower than 0.80. Conclusion The final translated and adapted version of the NIMH-LCM-S/P™ and its user guide were evaluated by the target population and the mental health professionals. Both groups displayed satisfactory comprehension levels, suggesting there is potential for using this instrument in clinical practice to assess therapeutic interventions in Brazilian settings.

Abstract In this review, we present some ethical imperatives observed in this pandemic from a data ethics perspective. Our exposition connects recurrent ethical problems in the discipline, such as, privacy, surveillance, transparency, accountability, and trust, to broader societal concerns about equality, discrimination, and justice. We acknowledge data ethic’s role as significant to develop technological, inclusive, and pluralist societies.

Resumen En esta revisión, exponemos algunos de los imperativos éticos observados desde la ética de datos en esta pandemia. Nuestra exposición busca conectar problemas éticos típicos dentro de esta disciplina, a saber, privacidad, vigilancia, transparencia, responsabilidad y confianza, con preocupaciones a nivel social relacionadas con la igualdad, discrimi nación y justicia. Consideramos que la ética de datos tiene un rol significativo para desarrollar sociedades tecnificadas, inclusivas y pluralistas.