Resumo O objetivo do trabalho foi comparar o comportamento de elementos climáticos e eventos térmicos extremos entre duas unidades de paisagem da cidade de Neuquén, Argentina, no período de 2013 a 2020. Foram analisados dados diários de temperatura mínima (Tmin), temperatura máxima (Tmax) e umidade relativa (UR) das estações meteorológicas “Neuquén Aero” (NA) e “Paseo de la Costa” (PC), que são referências do vale (área periurbana) e do corredor fluvial (ambiente ribeirinho), respectivamente. Foi analisada a influência da margem nas Tmin e Tmax diárias durante ondas de calor (OC) e ondas de frio (OF) no vale de acordo com a metodologia do Serviço Meteorológico Nacional. As médias de Tmax (Tmin), em resoluções anuais, sazonais e mensais, foram menores (maiores) em PC. Os valores médios de UR foram superiores em NA. Durante as OC, foi observado um efeito regulador em relação à quantidade de dias em que os valores limites foram excedidos de forma consecutiva no litoral fluvial.

Abstract This paper aimed to compare the behavior of climatic elements and extreme thermal events between two landscape units of the city of Neuquén, Argentina, for the period 2013-2020. The study involved daily data of minimum temperature (Tmin), maximum temperature (Tmax), and relative humidity (RH) obtained from the meteorological stations “Neuquén Aero” (NA) and “Paseo de la Costa” (PC), referring to the valley (peri-urban area) and the fluvial corridor (riparian environment) respectively. The influence of the riverbank on the daily Tmin and Tmax during Heat Waves (HW) and Cold Waves (CW) in the valley was analyzed using the methodology of the National Meteorological Service. The mean Tmax (Tmin), at annual, seasonal, and monthly resolutions, were lower (higher) in PC. The mean RH values were higher in NA. During the HW, a regulatory effect was exhibited regarding the number of days that the threshold values were exceeded consecutively in the fluvial littoral.

Resumen El objetivo del trabajo fue comparar el comportamiento de elementos climáticos y eventos térmicos extremos entre dos unidades de paisaje de la ciudad de Neuquén (Argentina) para el período 2013-2020. Se examinaron datos diarios de temperatura mínima -Tmin-, temperatura máxima -Tmax- y humedad relativa -HR- de las estaciones meteorológicas “Neuquén Aero” (NA) y “Paseo de la Costa” (PC), referentes del valle (área periurbana) y del corredor fluvial (entorno ripario) respectivamente. Se analizó la influencia de la ribera en las Tmin y Tmax diarias durante Olas de Calor (OC) y Olas de Frío (OF) en el valle según metodología del Servicio Meteorológico Nacional. Las Tmax (Tmin) medias, a resoluciones anual, estacional y mensual, resultaron menores (mayores) en PC. Los valores medios de HR fueron superiores en NA. Durante las OC, se exhibió un efecto regulador respecto a la cantidad de días que se excedieron los valores umbrales de manera consecutiva en el litoral fluvial.

Abstract Type 2 diabetes mellitus (T2DM) is associated with an increase of premature appearance of several disorders such as cardiac complications. Thus, we test the hypothesis that a combination of a high fat diet (HFD) and low doses of streptozotocin (STZ) recapitulate a suitable mice model of T2DM to study the cardiac mitochondrial disturbances induced by this disease. Animals were divided in 2 groups: the T2DM group was given a HFD and injected with 2 low doses of STZ, while the CNTRL group was given a standard chow and a buffer solution. The combination of HFD and STZ recapitulate the T2DM metabolic profile showing higher blood glucose levels in T2DM mice when compared to CNTRL, and also, insulin resistance. The kidney structure/function was preserved. Regarding cardiac mitochondrial function, in all phosphorylative states, the cardiac mitochondria from T2DM mice presented reduced oxygen fluxes when compared to CNTRL mice. Also, mitochondria from T2DM mice showed decreased citrate synthase activity and lower protein content of mitochondrial complexes. Our results show that in this non-obese T2DM model, which recapitulates the classical metabolic alterations, mitochondrial function is impaired and provides a useful model to deepen study the mechanisms underlying these alterations.

Los sarcomas de tejidos blandos son raros y representan menos del 1% de las neoplasias malignas recién diagnosticadas. La rareza de los tumores retroperitoneales, combinada con las variedades de subtipos histológicos, ha complicado los conocimientos sobre estos e impedido el desarrollo de terapia efectivas. Los liposarcomas retroperitoneales crecen lenta y silenciosamente, su pronóstico es malo y el tratamiento de elección es la resección quirúrgica. Se expone el caso de paciente femenino de 50 años de edad con el diagnóstico de ingreso de tumor abdominal, operada hace 39 meses por la misma causa, refiriendo liposarcoma tipo mixoide grado II, se realizó una laparotomía y se identificó masa tumoral retroperitoneal gigante con un peso de 6 100 gr. y se establece el diagnostico de tumor lipomatoso atipico/ liposarcoma bien diferenciado. Se informa este caso por la rareza de su conformación y la ausencia de reportes en la literatura nacional, con escasas patologías de similares características de presentación a nivel mundial.

Soft tissue sarcomas are rare and represent less than 1% of newly diagnosed malignancies. The rarity of retroperitoneal tumors, combined with the varieties of histological subtypes, has complicated the knowledge about these and impeded the development of effective therapy. Retroperitoneal liposarcomas grow slowly and silently, their prognosis is bad and the treatment of choice is surgical resection. We present the case of a female patient of 50 year old with a diagnosis of admission of an abdominal tumor, operated 39 months ago for the same cause, referring grade II myxoid-type liposarcoma, a laparotomy was performed and a giant retroperitoneal tumor was identified a weight of 6 100 gr. and the diagnosis of atypical lipomatous tumor / well differentiated liposarcoma is established. This case is reported due to the rarity of its conformation, the absence of reports in the national literature with few pathologies of similar presentation characteristics worldwide.