ABSTRACT Purpose: Statins are one of the most prescribed classes of drugs worldwide to treat hypercholesterolemia and dyslipidemia. By lowering the level of cholesterol, the use of statin could cause a reduction in testosterone levels. The objective was to evaluate whether the continued use of statins in patients with hypercholesterolemia causes a deficiency in testosterone and other sex hormones. Materials and Methods: Systematic Review with Meta-analysis, performed in Embase, Medline and Cochrane databases, until May 2023; PROSPERO CRD42021270424protocol. Selection performed by two independent authors with subsequent conference in stages. Methodology based on PRISMA statement. There were selected comparative studies, prospective cohorts (CP), randomized clinical trials (RCT) and cross-sectional studies (CSS) with comparison of testosterone levels before and after statin administration and between groups. Bias analysis were evaluated with Cochrane Tool, The Newcastle-Ottawa Scale (NOS), and using the Assess the Quality of Cross-sectional studies (AXIS) tool. Results: There were found on MedLine, Embase and Cochrane, after selected comparative studies, 10CP and 6RCT and 6CSS for the meta-analysis. In the Forrest plot with 6CSS, a correlation between patients with continuous use of statins and a reduction in total testosterone was evidenced with a statistically significant reduction of 55.02ng/dL (95%CI=[39.40,70.64],I²=91%,p<0.00001). In the analysis with 5RCT, a reduction in the mean total testosterone in patients who started continuous statin use was evidenced, with a statistical significance of 13.12ng/dL (95%CI=[1.16,25.08],I²=0%,p=0.03). Furthermore, the analysis of all prospective studies with 15 articles showed a statistically significant reduction in the mean total testosterone of 9.11 ng/dL (95%CI=[0.16,18.06],I²=37%,p=0.04). A reduction in total testosterone has been shown in most studies and in its accumulated analysis after statin use. However, this decrease was not enough to reach levels below normal. Conclusion: Statins use causes a decrease in total testosterone, not enough to cause a drop below the normal range and also determines increase in FSH levels. No differences were found in LH, Estradiol, SHBG and Free Testosterone analysis. Purpose dyslipidemia cholesterol hormones Methods Metaanalysis, Metaanalysis Meta analysis, Meta-analysis databases 2023 CRD42021270424protocol CRDprotocol CRD protocol stages statement CP, CP , (CP) RCT (RCT crosssectional cross sectional CSS (CSS groups Tool NewcastleOttawa Newcastle Ottawa NOS, NOS (NOS) Crosssectional Cross AXIS (AXIS tool Results MedLine metaanalysis. metaanalysis meta meta-analysis 5502ngdL ngdL 55 02ng dL ng 95%CI=39.40,70.64,I²=91%,p<0.00001. 95CI39407064I²91p000001 CIIp 95%CI= 39.40,70.64 ,I²=91%,p<0.00001 . 95 CI 39 40 70 64 I² 91 p 0 00001 I (95%CI=[39.40,70.64],I²=91%,p<0.00001) 5RCT 1312ngdL 13 12ng 95%CI=1.16,25.08,I²=0%,p=0.03. 95CI1162508I²0p003 1.16,25.08 ,I²=0%,p=0.03 1 16 25 08 03 (95%CI=[1.16,25.08],I²=0%,p=0.03) Furthermore 911 9 11 9.1 95%CI=0.16,18.06,I²=37%,p=0.04. 95CI0161806I²37p004 0.16,18.06 ,I²=37%,p=0.04 18 06 37 04 (95%CI=[0.16,18.06],I²=37%,p=0.04) However Conclusion LH Estradiol 202 (CP (NOS 5 95%CI=39.40,70.64,I²=91%,p<0.00001 95CI39407064I²91p00000 95CI 95%CI 39407064 39.40,70.6 I²91p000001 Ip ,I²=91%,p<0.0000 3 4 7 6 0000 (95%CI=[39.40,70.64],I²=91%,p<0.00001 95%CI=1.16,25.08,I²=0%,p=0.03 95CI1162508I²0p00 1162508 1.16,25.0 I²0p003 ,I²=0%,p=0.0 2 (95%CI=[1.16,25.08],I²=0%,p=0.03 9. 95%CI=0.16,18.06,I²=37%,p=0.04 95CI0161806I²37p00 0161806 0.16,18.0 I²37p004 ,I²=37%,p=0.0 (95%CI=[0.16,18.06],I²=37%,p=0.04 20 95%CI=39.40,70.64,I²=91%,p<0.0000 95CI39407064I²91p0000 3940706 39.40,70. I²91p00000 ,I²=91%,p<0.000 000 (95%CI=[39.40,70.64],I²=91%,p<0.0000 95%CI=1.16,25.08,I²=0%,p=0.0 95CI1162508I²0p0 116250 1.16,25. I²0p00 ,I²=0%,p=0. (95%CI=[1.16,25.08],I²=0%,p=0.0 95%CI=0.16,18.06,I²=37%,p=0.0 95CI0161806I²37p0 016180 0.16,18. I²37p00 ,I²=37%,p=0. (95%CI=[0.16,18.06],I²=37%,p=0.0 95%CI=39.40,70.64,I²=91%,p<0.000 95CI39407064I²91p000 394070 39.40,70 I²91p0000 ,I²=91%,p<0.00 00 (95%CI=[39.40,70.64],I²=91%,p<0.000 95%CI=1.16,25.08,I²=0%,p=0. 95CI1162508I²0p 11625 1.16,25 I²0p0 ,I²=0%,p=0 (95%CI=[1.16,25.08],I²=0%,p=0. 95%CI=0.16,18.06,I²=37%,p=0. 95CI0161806I²37p 01618 0.16,18 I²37p0 ,I²=37%,p=0 (95%CI=[0.16,18.06],I²=37%,p=0. 95%CI=39.40,70.64,I²=91%,p<0.00 95CI39407064I²91p00 39407 39.40,7 I²91p000 ,I²=91%,p<0.0 (95%CI=[39.40,70.64],I²=91%,p<0.00 95%CI=1.16,25.08,I²=0%,p=0 1162 1.16,2 I²0p ,I²=0%,p= (95%CI=[1.16,25.08],I²=0%,p=0 95%CI=0.16,18.06,I²=37%,p=0 0161 0.16,1 I²37p ,I²=37%,p= (95%CI=[0.16,18.06],I²=37%,p=0 95%CI=39.40,70.64,I²=91%,p<0.0 95CI39407064I²91p0 3940 39.40, I²91p00 ,I²=91%,p<0. (95%CI=[39.40,70.64],I²=91%,p<0.0 95%CI=1.16,25.08,I²=0%,p= 116 1.16, ,I²=0%,p (95%CI=[1.16,25.08],I²=0%,p= 95%CI=0.16,18.06,I²=37%,p= 016 0.16, ,I²=37%,p (95%CI=[0.16,18.06],I²=37%,p= 95%CI=39.40,70.64,I²=91%,p<0. 95CI39407064I²91p 394 39.40 I²91p0 ,I²=91%,p<0 (95%CI=[39.40,70.64],I²=91%,p<0. 95%CI=1.16,25.08,I²=0%,p 1.16 (95%CI=[1.16,25.08],I²=0%,p 95%CI=0.16,18.06,I²=37%,p 01 0.16 (95%CI=[0.16,18.06],I²=37%,p 95%CI=39.40,70.64,I²=91%,p<0 39.4 I²91p ,I²=91%,p< (95%CI=[39.40,70.64],I²=91%,p<0 1.1 0.1 95%CI=39.40,70.64,I²=91%,p< 39. ,I²=91%,p (95%CI=[39.40,70.64],I²=91%,p< 1. 0. 95%CI=39.40,70.64,I²=91%,p (95%CI=[39.40,70.64],I²=91%,p

Abstract The Atlantic goliath grouper Epinephelus itajara is the largest grouper species in the Atlantic Ocean. Despite the conservation status being Vulnerable (VU) globally and Critically Endangered (CR) in Brazil, the species continues to face threats from overfishing throughout its range. We used DNA barcoding employing the mitochondrial Cytochrome c oxidase subunit I (COI) gene to identify the illegal commercialization of E. itajara in fish markets from the northern (NC) and southern (SC) Brazilian coasts. Sampling was conducted in fish markets and aimed to confirm the identification of mischaracterized fish sold as E. itajara in the NC, as well as identifying fish fillets sold as the Dusky grouper in the SC. DNA barcoding allowed the unambiguous identification of 22 (84.6%) of the 26 analyzed fish market samples. Both sampled areas had confirmation of E. itajara illegal commercialization and from the 22 analyzed samples, 17 (77.3%) were confirmed to be E. itajara. Here we report two crimes, the illegal sale of E. itajara and commercial fraud by species substitution. This study has highlighted that the existing legislation that protects E. itajara in Brazilian waters requires the adoption of better public policies for the conservation of the species. Ocean VU (VU CR (CR Brazil range COI (COI E NC (NC SC (SC coasts 2 84.6% 846 84 6 (84.6% samples 1 77.3% 773 77 3 (77.3% crimes substitution 84.6 8 (84.6 77.3 7 (77.3 84. (84. 77. (77. (84 (77 (8 (7 (

Resumo O mero do Atlântico Epinephelus itajara é a maior espécie de garoupa no Oceano Atlântico. Apesar do seu status de conservação Vulnerável (VU) globalmente e Criticamente em Perigo (CR) no Brasil, a espécie continua enfrentando ameaças da sobrepesca em toda a sua área de distribuição. Utilizamos o sequenciamento de DNA por código de barras, empregando o gene mitocondrial da Citocromo c oxidase subunidade I (COI), para identificar a comercialização ilegal de E. itajara em mercados de peixe nas costas norte (CN) e sul (CS) do Brasil. A coleta de amostras foi realizada em mercados de peixe e teve como objetivo confirmar a identificação de peixes descaracterizados e vendidos como E. itajara na CN, bem como identificar filés de peixe vendidos como garoupa verdadeira na CS. O sequenciamento de DNA por código de barras permitiu a identificação inequívoca de 22 (84,6%) das 26 amostras de mercado de peixe analisadas. Ambas as áreas amostradas tiveram confirmação da comercialização ilegal de E. itajara, e das 22 amostras analisadas, 17 (77,3%) foram confirmadas como E. itajara. Nós relatamos aqui dois crimes, a venda ilegal de E. itajara e a fraude comercial por substituição de espécies. Este estudo ressaltou que a legislação existente que protege E. itajara em águas brasileiras requer a adoção de melhores políticas públicas para a conservação da espécie. VU (VU CR (CR Brasil distribuição COI, COI , (COI) E CN (CN CS (CS 2 84,6% 846 84 6 (84,6% analisadas 1 77,3% 773 77 3 (77,3% crimes espécies (COI 84,6 8 (84,6 77,3 7 (77,3 84, (84, 77, (77, (84 (77 (8 (7 (

ABSTRACT Purpose To investigate whether there are differences in cepstral and spectral acoustic measures between women with behavioral dysphonia with and without laryngeal lesions and verify whether there is a correlation between such measures and the auditory-perceptual evaluation of voice quality. Methods The sample comprised 78 women with behavioral dysphonia without laryngeal lesions (BDWOL) and 68 with behavioral dysphonia with laryngeal lesions (vocal nodules) (BDWL). Cepstral peak prominence (CPP), cepstral peak prominence-smoothed (CPPS), spectral decrease, and H1-H2 (difference between the amplitude of the first and second harmonics) were extracted. They were submitted to the auditory-perceptual evaluation (APE) of the grade of hoarseness (GH), roughness (RO), breathiness (BR), and strain (ST). Results BDWL women had higher H1-H2 values and lower CPP and CPPS values than BDWOL women. More deviant voices had lower CPP and CPPS values. Breathy voices had lower CPP and CPPS values and higher H1-H2 values than rough ones. There was a weak negative correlation between CPP and RO, a moderate negative correlation with GH, and a strong negative correlation with BR. CPPS had a moderate negative correlation with GH, RO, and BR. H1-H2 had a weak positive correlation with BR. There was a weak positive correlation between spectral decrease and ST. Conclusion H1-H2, CPP, and CPPS were different between BDWOL and BDWL women. Furthermore, cepstral and spectral measures were correlated with the different APE parameters. auditoryperceptual auditory perceptual quality 7 (BDWOL 6 vocal nodules BDWL. . (BDWL) , (CPP) prominencesmoothed smoothed CPPS, (CPPS) H1H2 HH H1 H2 H H1-H difference harmonics extracted (APE GH (GH) RO (RO) BR, BR (BR) ST (ST) ones H1H2, H2, Furthermore parameters (BDWL (CPP (CPPS H1H (GH (RO (BR (ST

RESUMO Objetivo Investigar se existem diferenças nas medidas acústicas cepstrais e espectrais entre mulheres com disfonia comportamental com e sem lesão laríngea, bem como verificar se existe correlação entre tais medidas e o julgamento perceptivo-auditivo da qualidade vocal. Método Participaram 78 mulheres com disfonia comportamental sem lesão laríngea (DCSL) e 68 com disfonia comportamental com lesão laríngea (nódulos vocais) (DCCL). Foram extraídas as medidas CPP (cepstral peak prominence), CPPS (cepstral peak prominence smoothed), declínio espectral e H1-H2 (diferença entre a amplitude do primeiro e do segundo harmônico), assim como o julgamento perceptivo-auditivo (JPA) do grau geral de desvio vocal (GG), graus de rugosidade (GR), de soprosidade (GS) e de tensão (GT). Resultados Mulheres com DCCL apresentaram maiores valores de H1-H2 e menores valores no CPP e CPPS, em relação às mulheres com DCSL. As vozes mais desviadas apresentaram menores valores do CPP e CPPS. As vozes soprosas apresentaram menores valores de CPP e CPPS, assim como maior valor de H1-H2 em relação às vozes rugosas. Houve correlação negativa fraca entre o CPP e o GR, negativa moderada com o GG e negativa forte com o GS. O CPPS apresentou correlação negativa moderada com o GG, GR e GS. A medida H1-H2 apresentou correlação positiva fraca com o GS. Houve correlação positiva fraca entre o declínio espectral e o GT. Conclusão As medidas acústicas H1-H2, CPP e CPPS apresentam diferenças entre mulheres com DCSL e DCCL. Além disso, há correlação entre as medidas cepstrais e espectrais e os diferentes parâmetros do JPA. perceptivoauditivo perceptivo auditivo 7 (DCSL 6 nódulos vocais . (DCCL) cepstral prominence, , prominence) smoothed, smoothed smoothed) H1H2 HH H1 H2 H H1-H diferença harmônico, harmônico harmônico) JPA (JPA (GG) (GR) GS (GS GT (GT) rugosas H1H2, H2, disso (DCCL H1H (GG (GR (GT

ABSTRACT present study aimed to determine the effects of different light restriction levels (shading levels) on soybean genetic parameters using a Bayesian multi-trait model (MTM) and select high-yielding soybean cultivars. Eighteen commercial soybean cultivars bred in a soybean breeding program were evaluated over two agricultural seasons. Three shading levels were used over two agricultural crop seasons, giving six treatments (light restriction × crop season). The experiments were arranged in a randomized complete block design with six treatments replicated thrice. The genetic values and parameters were estimated using a Monte Carlo Markov Chain algorithm. Broad-sense heritability range from 0.2093 to 0.7153. The lowest genotypic variance estimate was observed at the 45 % photosynthetically active radiation level in the 2019/2020 crop season year compared with that of other shading levels. Furthermore, a 40 % selection intensity had the highest soybean yield under different shading levels. The Bayesian MTM combined with the factor analysis and genotype-ideotype distance method can be used to evaluate and select soybean genotypes considering different shading levels. The soybean cultivars 8579RSF, NS8338, NS7901, NS7667, RK8115, and 8473RSF had higher genetic potential than other cultivars under different shading levels. multitrait multi trait (MTM highyielding high yielding seasons season. . season) thrice algorithm Broadsense Broad sense 02093 0 2093 0.209 07153 7153 0.7153 4 20192020 2019 2020 2019/202 Furthermore genotypeideotype genotype ideotype 8579RSF RSF NS8338 NS NS7901 NS7667 RK8115 RK 0209 209 0.20 0715 715 0.715 2019202 201 202 2019/20 NS833 NS790 NS766 RK811 020 20 0.2 071 71 0.71 201920 2019/2 NS83 NS79 NS76 RK81 02 2 0. 07 7 0.7 20192 2019/ NS8 NS7 RK8

ABSTRACT Purpose To develop the validity step based on the response processes of the Spectrographic Analysis Protocol (SAP). Methods 10 speech therapists and 10 undergraduate students of the Speech Therapy course were recruited, who applied the SAP in 10 spectrograms, performed the evaluation of the PAE items, and participated in a cognitive interview (CI). The SAP was reanalyzed to reformulate or exclude items based on the responses. The chi-square test and the accuracy values were used to analyze the answers to the questionnaires and qualitative analysis of the CI data. Results the participants achieved accuracy > 70% in most items of the SAP. Only seven items achieved accuracy ≤ 70%. There was a difference between presence vs. absence of difficulty in identifying items in the spectrogram. Most participants had no problem identifying the SAP items. In the CI, only six items did not correctly identify the intention, verified in the qualitative analysis. In addition, participants suggested excluding five items. Conclusion After the validation step based on the response processes, the SAP is reformulated. Seven items were deleted, and two items were reformulated. Thus, the final version of the SAP after this stage was reduced from 25 to 18 items, distributed in the five domains. . (SAP) 1 recruited spectrograms CI. (CI) responses chisquare chi square data 70 vs spectrogram intention addition reformulated deleted Thus 2 domains (SAP (CI 7

RESUMO Objetivo desenvolver a etapa de validade baseada nos processos de resposta do Protocolo de Análise Espectrográfica da Voz (PAEV). Métodos foram recrutados dez fonoaudiólogos e dez alunos de graduação em Fonoaudiologia, que aplicaram o PAEV em dez espectrogramas, realizaram o julgamento dos itens do PAEV e participaram de uma entrevista cognitiva. A partir das respostas, o PAEV foi reanalisado para reformulação ou para exclusão de itens. Utilizou-se o teste Qui-Quadrado e os valores de acurácia para análise das respostas dos questionários, assim como análise qualitativa dos dados da entrevista cognitiva. Resultados os participantes obtiveram acurácia maior que 70% na maioria dos itens do PAE. Apenas sete itens alcançaram acurácia menor ou igual a 70%. Houve diferença entre as respostas de presença versus ausência de dificuldade na identificação dos itens no espectrograma. A maioria dos participantes não teve dificuldade na identificação dos itens do PAEV. Na entrevista cognitiva, apenas seis itens não obtiveram correta identificação da intenção, conforme verificado na análise qualitativa. Além disso, os participantes sugeriram exclusão de cinco itens. Conclusão após a etapa de validação baseada nos processos de resposta, o PAEV foi reformulado. Sete itens foram excluídos e dois itens foram reformulados. Dessa forma, a versão final do PAEV após essa etapa foi reduzida de 25 para 18 itens, distribuídos nos cinco domínios. . (PAEV) Fonoaudiologia espectrogramas cognitiva Utilizouse Utilizou se QuiQuadrado Qui Quadrado questionários 70 PAE espectrograma intenção disso reformulado reformulados forma 2 1 domínios (PAEV 7

This is an initial study using infrared (IR) in silico data as a standard database in preliminary method for new synthetic seized drugs. For this purpose, ten of the most common synthetic illicit seized substances on the Brazilian market were compared and computational chemistry was used as a tool for theoretical standard database. Infrared data from standard electronic library, experimental data from seized samples and data simulated by Density Functional Theory (DFT) were evaluated. The feasibility of the method was based on the degree of correlation of evaluated data. The results suggest that the computational methodology can be a viable way to analyze the structures of new synthetic drugs and obtain preliminary infrared profiles. Correlations data indicated a presumptive identification of the analyzed samples and it was also possible to observe a preliminary identification of drugs in five classes. However, it was observed that some synthetic cathinones and phenylethylamines were confused with amphetamines. Therefore, new studies must be developed to optimize the use of these data, because the simulated IR spectra can be advantageous to evaluate the profile of possible substances that may be synthesized in the future. (IR purpose library DFT (DFT profiles classes However amphetamines Therefore future

Abstract This opinion article consists of an interview with Leonardo Peçanha, a Black trans man, a human rights and trans people rights activist and a researcher in Collective Health. In this interview, he reflects intersectionally on the place of beauty, body changes, and physical activity in the gender transition process of trans and transmasculine men. He discusses the (im)possibilities of trans people in high-performance sports and tells us about the Mister Trans Brazil beauty pageant contest. Peçanha man Health changes men impossibilities im possibilities highperformance high performance contest

Resumo Este artigo de opinião consiste em uma entrevista realizada com Leonardo Peçanha, um homem negro trans, ativista no campo dos direitos humanos e dos direitos das pessoas trans e pesquisador do campo da Saúde Coletiva. Na conversa que se segue Leonardo Peçanha, de forma interseccional, reflete sobre o lugar da beleza, modificações corporais e atividade física no processo de transição de gênero de sujeitos homens trans e transmasculinos, como também toca no tema das (im)possibilidades das pessoas trans no campo dos esportes de alto rendimento e nos conta sobre o concurso de beleza Mister Trans Brasil. Peçanha Coletiva interseccional transmasculinos impossibilidades im possibilidades Brasil

ABSTRACT This study aimed to investigate the effects of different levels of vitamin D3 in broiler diets on performance and bone health. A total of 360 one-day old male Cobb500® broiler chicks were subjected to five treatments of different levels of vitamin D3 in diets during two rearing phases: 0 IU/kg in both phases; 625 IU/kg in starter and 500 IU/kg in grower phase (25% of commercial inclusion); 1,250 IU/kg in starter and 1,000 IU/kg in grower phase (50% of commercial inclusion); 1,875 IU/kg in starter and 1,500 IU/kg in grower phase (75% of commercial inclusion); and 2,500 IU/kg in starter and 2,000 IU/kg in grower phase (100% of commercial inclusion). The traits studied weekly were feed intake, body weight, feed conversion, and viability. At 21 and 35 days of age, tibiae and femurs were removed, dissected, and evaluated for dry matter (DM), ash (%MM), calcium (%Ca), phosphorus (%P) and breaking strength. At 35 days of age, the bones were subjected to histopathological analysis for macro- and microscopic morphological evaluation. Data were subjected to regression analysis, using α = 0.05. The variables of percentage %MM, %Ca, %P, and breaking strength experienced a positive linear effect up to the supplementation levels of approximately 25% of inclusion. The histopathological analysis found that the group that received the diet with 100% inclusion of vitamin D3 presented lesions compatible with osteopetrosis and tibial dyschondroplasia. The observed results showed that for isonutritive diets, reduced levels of vitamin D3 guaranteed performance during the evaluated period while the use of 100% of vitamin D3, as commonly used, can cause bone diseases and harm the welfare of broilers. D health 36 oneday one day Cobb500 Cobb phases IUkg IU kg 62 50 25 (25 inclusion) 1250 1 250 1,25 1000 000 1,00 50% (50 1875 875 1,87 1500 1,50 75% 75 (75 2500 2 2,50 2000 2,00 100 (100 . intake weight conversion viability 3 age removed dissected DM, DM , (DM) MM %MM (%MM) Ca %Ca (%Ca) %P P (%P macro evaluation 005 05 0.05 dyschondroplasia used broilers Cobb50 6 5 (2 125 1,2 00 1,0 (5 187 87 1,8 150 1,5 7 (7 2,5 200 2,0 10 (10 (DM (%MM (%Ca 0.0 Cobb5 ( 12 1, 18 8 15 2, 20 (1 0.

ABSTRACT Purpose: To evaluate the effects on peripheral neural regeneration of the end-to-side embracing repair technique compared to the autograft repair technique in Wistar rats. Methods: Fifteen male Wistar rats were divided into three groups with five animals each: denervated group (GD), autograft group (GA), and embracing group (EG). For the evaluation, the grasping test, electroneuromyography (ENMG), and muscle weight assessment were used. Results: Muscle weight assessment and ENMG did not show significant neural regeneration at the end of 12 weeks in the DG and GE groups, but only in GA. The grasping test showed an increase in strength between the surgery and the fourth week in all groups, and only the GA maintained this trend until the 12th week. Conclusions: The present study indicates that the neural regeneration observed in the end-to-side embracing neurorrhaphy technique, in the repair of segmental neural loss, is inferior to autograft repair in Wistar rats. Purpose endtoside side Methods each GD, GD , (GD) GA, (GA) EG. EG . (EG) evaluation ENMG, (ENMG) used Results 1 th Conclusions loss (GD (GA (EG (ENMG

RESUMO Introdução: O conceito do cuidado seguro permeia as instituições de saúde no mundo todo, no entanto, é preciso entender a cultura de segurança de uma instituição para melhorar a oferta de segurança aos pacientes e aos profissionais. Metodologia: Estudo transversal com abordagem quantitativa. A amostra foi composta por 119 profissionais de saúde que compunham a equipe multiprofissional do centro cirúrgico nos meses de agosto a setembro de 2021, onde ocorreu a coleta de dados. Foi utilizado o instrumento Hospital Survey on Patient Safety Culture (HSOPSC), para avaliar as doze dimensões que compõem a cultura de segurança do paciente. A análise dos dados foi feita através de estatística descritiva, para avaliar a confiabilidade das respostas ao instrumento HSOPSC, utilizou-se o teste Alpha de Cronbach. Resultados: Das doze dimensões avaliadas, não houve nenhuma dimensão considerada forte para segurança do paciente na unidade. As dimensões com potencial para segurança do paciente foram “Expectativas e ações do supervisor/chefia para a promoção da segurança do paciente”; “Trabalho em equipe dentro das unidades” e “Aprendizado organizacional - melhoria contínua”, enquanto todas as outras dimensões foram avaliadas como fracas para segurança do paciente. 39,50% dos participantes consideram a segurança do paciente na unidade como regular, apesar disso 89,91% dos participantes relataram não ter realizado nenhuma notificação de evento nos últimos 12 meses. Conclusão: O estudo apontou a necessidade do fortalecimento de todas as dimensões da cultura de segurança do paciente pela equipe do hospital pesquisado, uma vez que nenhuma delas foi apontada como forte. Introdução todo entanto Metodologia quantitativa 11 2021 HSOPSC , (HSOPSC) descritiva utilizouse utilizou se Cronbach Resultados Expectativas supervisorchefia supervisor chefia paciente” Trabalho unidades Aprendizado contínua, contínua contínua” 3950 39 50 39,50 regular 8991 89 91 89,91 1 Conclusão pesquisado 202 (HSOPSC 395 3 5 39,5 899 8 9 89,9 20 39, 89, 2

ABSTRACT Introduction: The concept of safe care permeates health institutions around the world, however, it is necessary to understand the safety culture of an institution to improve the provision of safety to patients and professionals. Methodology: Cross-sectional study with a quantitative approach. The sample was made up of 119 health professionals who made up the multidisciplinary team at the surgical center from August to September 2021, where data collection took place. The Hospital Survey on Patient Safety Culture (HSOPSC) instrument was used to evaluate the twelve dimensions that make up patient safety culture. Data analysis was carried out using descriptive statistics, to evaluate the reliability of the responses to the HSOPSC instrument, the Cronbachs Alpha test was used. Results: Of the twelve dimensions evaluated, there was no dimension considered strong for patient safety in the unit. The dimensions with potential for patient safety were “Expectations and actions of the supervisor/manager to promote patient safety”; “Teamwork within units” and “Organizational learning - continuous improvement”, while all other dimensions were evaluated as weak for patient safety. 39.50% of participants consider patient safety in the unit to be regular, despite this, 89.91% of participants reported not having made any event notifications in the last 12 months. Conclusion: The study highlighted the need to strengthen all dimensions of the patient safety culture by the team at the hospital studied, as none of them were identified as strong. Introduction world however Methodology Crosssectional Cross sectional approach 11 2021 place (HSOPSC statistics Results Expectations supervisormanager supervisor manager safety” Teamwork units Organizational improvement, improvement , improvement” 3950 39 50 39.50 regular this 8991 89 91 89.91 1 months Conclusion studied 202 395 3 5 39.5 899 8 9 89.9 20 39. 89. 2

RESUMO Objetivo: Verificar a associação entre baixa qualidade do sono autorrelatada (BQS) e quedas em adultos de meia-idade e idosos a cada meia década de vida. Método: Um estudo transversal foi conduzido utilizando dados da primeira onda (2015–2016) do Estudo Longitudinal Brasileiro do Envelhecimento (ELSI-Brasil), que é nacionalmente representativo. A população consistiu em 8.950 participantes que foram alocados em oito grupos etários: 50–54, 55–59, 60–64, 65–69, 70–74, 75–79, 80–84 e ≥ 85 anos. Os questionários utilizados incluíram qualidade do sono autorrelatada e o Questionário Internacional de Atividade Física versão curta. O teste exato de Fisher seguido pela análise de regressão logística binária foi conduzida para identificar a razão de chances da BQS para ocorrência de queda, controlando por variáveis de confusão. Resultados: Pessoas com idades entre 50 e 105 anos (63,6 ± 10,2 anos), sendo 57,0% do sexo feminino e 43,0% do sexo masculino, participaram deste estudo. No geral, 21,5% dos participantes experimentaram pelo menos uma queda. A frequência relativa de participantes classificados como tendo BQS ou alta permaneceu constante em cada meia década de vida. A BQS exibiu uma OR (p < 0,05) notável para quedas em grupos etários até 84 anos, mesmo após o ajuste para variáveis de confusão. Conclusão: A BQS está significativamente associada a uma maior ocorrência de queda em adultos com mais de 50 anos, mas não para ≥ 85 anos, independentemente do sexo e do nível de atividade física. Objetivo (BQS meiaidade idade vida Método 2015–2016 20152016 2015 2016 (2015–2016 ELSIBrasil, ELSIBrasil ELSI Brasil , (ELSI-Brasil) representativo 8950 8 950 8.95 5054 54 50–54 5559 55 59 55–59 6064 60 64 60–64 6569 65 69 65–69 7074 70 74 70–74 7579 75 79 75–79 8084 80 80–8 curta confusão Resultados 5 10 63,6 636 63 6 (63, 102 2 10, anos) 570 57 0 57,0 430 43 43,0 masculino geral 215 21 21,5 p 0,05 005 05 Conclusão física 2015–201 2015201 201 (2015–201 (ELSI-Brasil 895 95 8.9 505 50–5 555 55–5 606 60–6 656 65–6 707 7 70–7 757 75–7 808 80– 1 63, (63 57, 4 43, 21, 0,0 00 2015–20 201520 20 (2015–20 89 9 8. 50– 55– 60– 65– 70– 75– (6 0, 2015–2 20152 (2015–2 ( 2015– (2015– (2015 (201 (20 (2

RESUMEN Objetivo: Verificar la asociación entre la baja calidad del sueño autorreportada (BCS) y las caídas en adultos de mediana edad y mayores cada media década de vida. Método: Se realizó un estudio transversal utilizando datos de la primera oleada (2015–2016) del Estudio Longitudinal Brasileño sobre el Envejecimiento (ELSI-Brasil), que es representativo a nivel nacional. La muestra consistió en 8,950 participantes que fueron asignados a ocho grupos de edad: 50–54, 55–59, 60–64, 65–69, 70–74, 75–79, 80–84 y ≥ 85 años. Los cuestionarios utilizados incluyeron calidad del sueño autorreportada y el Cuestionario Internacional de Actividad Física versión corta. Se realizó una prueba exacta de Fisher seguida por un análisis de regresión logística binaria para identificar la razón de probabilidades de la calidad del sueño para la ocurrencia de caídas, controlando las variables de confusión. Resultados: Participaron en este estudio individuos con edades entre 50 y 105 años (63,6 ± 10,2 años), siendo el 57,0% mujeres y el 43,0% hombres. En general, el 21,5% de los participantes experimentaron al menos una caída. La frecuencia relativa de participantes clasificados como con alta calidad de sueño o baja calidad de sueño (BCS) se mantuvo constante a lo largo de cada media década de vida. La BCS mostró un OR (p < 0,05) notable para las caídas en grupos de edad hasta los 84 años, incluso después de ajustar por variables de confusión. Conclusión: La BCS está significativamente asociada con una mayor ocurrencia de caídas en adultos mayores de 50 años, pero no para ≥ 85 años, independientemente del sexo y del nivel de actividad física. Objetivo (BCS vida Método 2015–2016 20152016 2015 2016 (2015–2016 ELSIBrasil, ELSIBrasil ELSI Brasil , (ELSI-Brasil) nacional 8950 8 950 8,95 5054 54 50–54 5559 55 59 55–59 6064 60 64 60–64 6569 65 69 65–69 7074 70 74 70–74 7579 75 79 75–79 8084 80 80–8 corta confusión Resultados 5 10 63,6 636 63 6 (63, 102 2 10, años) 570 57 0 57,0 430 43 43,0 hombres general 215 21 21,5 caída p 0,05 005 05 Conclusión física 2015–201 2015201 201 (2015–201 (ELSI-Brasil 895 95 8,9 505 50–5 555 55–5 606 60–6 656 65–6 707 7 70–7 757 75–7 808 80– 1 63, (63 57, 4 43, 21, 0,0 00 2015–20 201520 20 (2015–20 89 9 8, 50– 55– 60– 65– 70– 75– (6 0, 2015–2 20152 (2015–2 ( 2015– (2015– (2015 (201 (20 (2

ABSTRACT Objective: To verify the association between low self-reported sleep quality (LSQ) and fall in middle-aged and older adults every half-decade of life. Method: A cross-sectional study was conducted using data from the first wave (2015–2016) of the Brazilian Longitudinal Study of Aging (ELSI-Brazil), which is nationally representative. The sample consisted of 8,950 participants who were allocated into eight age groups: 50–54, 55–59, 60–64, 65–69, 70–74, 75–79, 80–84, and ≥ 85 years. The questionnaires used included self-reported sleep quality and the International Physical Activity Questionnaire short version. Fisher’s exact test followed by binary logistic regression analysis was performed to identify the odds ratio of sleep quality for fall occurrence, controlled for confounding variables. Results: Individuals aged 50–105 years (63.6 ± 10.2 years), 57.0% females and 43.0% males, participated in this study. Overall, 21.5% of participants experienced at least one fall. The relative frequency of participants classified as having high or LSQ remained constant across each half-decade of life. The LSQ exhibited a statistically significant OR (p < 0.05) for falls across age groups up to 84, even after accounting for confounding variables. Conclusion: LSQ is significantly associated with an increased occurrence of fall in adults aged >50 years, but not for ≥ 85 years regardless of sex and physical activity level. Objective selfreported self reported (LSQ middleaged middle halfdecade half decade life Method crosssectional cross sectional 2015–2016 20152016 2015 2016 (2015–2016 ELSIBrazil, ELSIBrazil ELSI Brazil , (ELSI-Brazil) representative 8950 8 950 8,95 5054 50 54 50–54 5559 55 59 55–59 6064 60 64 60–64 6569 65 69 65–69 7074 70 74 70–74 7579 75 79 75–79 8084 80 84 80–84 version Fishers Fisher s variables Results 50105 105 50–10 63.6 636 63 6 (63. 102 10 2 10. years) 570 57 0 57.0 430 43 43.0 males Overall 215 21 5 21.5 p 0.05 005 05 Conclusion >5 level 2015–201 2015201 201 (2015–201 (ELSI-Brazil 895 95 8,9 505 50–5 555 55–5 606 60–6 656 65–6 707 7 70–7 757 75–7 808 80–8 5010 50–1 63. (63 1 57. 4 43. 21. 0.0 00 > 2015–20 201520 20 (2015–20 89 9 8, 50– 55– 60– 65– 70– 75– 80– 501 (6 0. 2015–2 20152 (2015–2 ( 2015– (2015– (2015 (201 (20 (2

Abstract This opinion article consists of an interview with Leonardo Peçanha, a Black trans man, a human rights and trans people rights activist and a researcher in Collective Health. In this interview, he reflects intersectionally on the place of beauty, body changes, and physical activity in the gender transition process of trans and transmasculine men. He discusses the (im)possibilities of trans people in high-performance sports and tells us about the Mister Trans Brazil beauty pageant contest.

Resumo Este artigo de opinião consiste em uma entrevista realizada com Leonardo Peçanha, um homem negro trans, ativista no campo dos direitos humanos e dos direitos das pessoas trans e pesquisador do campo da Saúde Coletiva. Na conversa que se segue Leonardo Peçanha, de forma interseccional, reflete sobre o lugar da beleza, modificações corporais e atividade física no processo de transição de gênero de sujeitos homens trans e transmasculinos, como também toca no tema das (im)possibilidades das pessoas trans no campo dos esportes de alto rendimento e nos conta sobre o concurso de beleza Mister Trans Brasil.

Resumo O objetivo deste trabalho foi comparar o uso de a priori não informativas e informativas em modelos bayesianos, bem como avaliar a viabilidade da inclusão de a priori informativas na estimativa dos componentes de variância e dos valores genotípicos em programas de melhoramento de soja. Os dados fenotípicos utilizados referem-se à avaliação de 80 genótipos de soja, em dez ambientes, ao longo de três anos. Para cada safra avaliada, foram utilizadas a priori informativas e não informativas, e os parâmetros foram estimados com uso do algoritmo de amostragem de Gibbs. As estimativas dos parâmetros da safra anterior foram utilizadas como informação prévia para a próxima safra avaliada. A qualidade do ajuste foi calculada com uso do critério de informação de desvio (DIC). A acurácia seletiva apresentou maiores valores nos modelos escolhidos por meio do DIC, para ambas as safras. No entanto, os intervalos de maior densidade a posteriori são menores para todos os modelos que adotaram a priori informativas. Adicionar informações à inferência bayesiana nem sempre resulta em melhor ajuste ao modelo. bayesianos soja referemse referem se 8 ambientes anos avaliada Gibbs DIC. DIC . (DIC) safras entanto modelo (DIC

Abstract The objective of this work was to compare the use of noninformative and informative priors in Bayesian models, as well as to evaluate the viability of including informative priors in the estimation of variance components and genetic values in soybean breeding programs. The used phenotypic data refer to the evaluation of 80 soybean genotypes in ten environments over three years. For each evaluated crop year, informative and noninformative priors were used, and the parameters were estimated using the Gibbs sampler algorithm. Parameter estimates from the previous crop year were used as prior information for the next evaluated crop year. The goodness-of-fit was calculated using the deviance information criterion (DIC). Selective accuracy showed the highest values for the models chosen through DIC for both crop years. However, the intervals of the highest posterior density are narrower for all models that adopted informative priors. Adding information into Bayesian inference does not always result in a better model fitting. programs 8 years algorithm goodnessoffit goodness fit DIC. . (DIC) However fitting (DIC

Objectives: To summarize evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The literature on CBT interventions for adult OCD, including BT and exposure and response prevention, was systematically reviewed to develop updated clinical guidelines for clinicians, providing comprehensive details about the necessary procedures for the CBT protocol. We searched the literature from 2013-2020 in five databases (PubMed, Cochrane, Embase, PsycINFO, and Lilacs) regarding study design, primary outcome measures, publication type, and language. Selected articles were assessed for quality with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association. Results: We examined 44 new studies used to update the 2013 American Psychiatric Association guidelines. High-quality evidence supports CBT with exposure and response prevention techniques as a first-line treatment for OCD. Protocols for Internet-delivered CBT have also proven efficacious for adults with OCD. Conclusion: High-quality scientific evidence supports the use of CBT with exposure and response prevention to treat adults with OCD. Objectives evidencebased based cognitivebehavioral cognitive behavioral (CBT obsessivecompulsive obsessive compulsive OCD . (OCD) Methods clinicians protocol 20132020 2020 2013-202 PubMed, PubMed (PubMed Cochrane Embase PsycINFO Lilacs design measures type language tools Results 4 201 Highquality High firstline first line Internetdelivered Internet delivered Conclusion (OCD 2013202 202 2013-20 20 201320 2013-2 2 20132 2013-