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Abstract Sjogren’s disease (SjD) is an autoimmune disease that is characterized not only by the sicca symptoms it causes but also by its systemic nature, which is capable of several and not yet fully understood extraglandular manifestations. To gain a clearer understanding of these manifestations as well as a better practical approach, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of the extraglandular manifestations present in ESSDAI (EULAR Sjogren´s syndrome disease activity index), followed by a voting panel with recommendations for clinical practice. This publication is complementary to others already published and covers cutaneous and hematological manifestations, with prevalence data generated by a meta-analysis of 13 clinical or laboratory manifestations and 6 clinical management recommendations. Sjogrens Sjogren s SjD (SjD nature approach metaanalysis meta analysis EULAR index, index , index) practice 1

https://doi.org/10.1186/s42358-024-00391-x

The SISBIOTA-Diptera Brazilian Network: A long-term survey of Diptera from unexplored Brazilian Western Arc of Amazon, Cerrado, and Pantanal SISBIOTADiptera SISBIOTA Network longterm long term Amazon Cerrado
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Lamas, Carlos José Einicker

; Fachin, Diego Aguilar

; Falaschi, Rafaela Lopes

; Alcantara, Daniel Máximo Correa de

; Ale-Rocha, Rosaly

; Amorim, Dalton de Souza

; Araújo, Maíra Xavier

; Ascendino, Sharlene

; Baldassio, Letícia

; Bellodi, Carolina Ferraz

; Bravo, Freddy

; Calhau, Julia

; Capellari, Renato Soares

; Carmo-Neto, Antonio Marcelino do

; Cegolin, Bianca Melo

; Couri, Márcia Souto

; Carvalho, Claudio José Barros de

; Dios, Rodrigo de Vilhena Perez

; Falcon, Aida Vanessa Gomez

; Fusari, Livia Maria

; Garcia, Carolina de Almeida

; Gil-Azevedo, Leonardo Henrique

; Gomes, Marina Morim

; Graciolli, Gustavo

; Gudin, Filipe Macedo

; Henriques, Augusto Loureiro

; Krolow, Tiago Kütter

; Mendes, Luanna Layla

; Limeira-de-Oliveira, Francisco

; Maia, Valéria Cid

; Marinoni, Luciane

; Mello, Ramon Luciano

; Mello-Patiu, Cátia Antunes de

; Morales, Mírian Nunes

; Oliveira, Sarah Siqueira

; Patiu, Claudemir

; Proença, Barbara

; Pujol-Luz, Cristiane Vieira de Assis

; Pujol-Luz, José Roberto

; Rafael, José Albertino

; Riccardi, Paula Raile

; Rodrigues, João Paulo Vinicios

; Roque, Fabio de Oliveira

; Sallum, Maria Anice Mureb

; Santis, Marcelo Domingos de

; Santos, Charles Morphy Dias dos

; Santos, Josenilson Rodrigues dos

; Savaris, Marcoandre

; Shimabukuro, Paloma Helena Fernandes

; Silva, Vera Cristina

; Schelesky-Prado, Daniel de Castro

; Silva-Neto, Alberto Moreira da

; Camargo, Alexssandro

; Sousa, Viviane Rodrigues de

; Urso-Guimarães, Maria Virginia

; Wiedenbrug, Sofia

; Yamaguchi, Carolina

; Nihei, Silvio Shigueo

Revista Brasileira de Entomologia

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2023, Volume 67 Nº 4 elocation e20230051

Resumo: En | Texto: En | PDF: En

ABSTRACT The SISBIOTA-BRASIL was a three-year multimillion-dollar research program of the Brazilian government to document plants and animals in endangered/understudied areas and biomes in Brazil. Distributional patterns and the historical events that generated them are extensively unknown regarding Brazilian fauna and flora. This deficiency hinders the development of conservation policies and the understanding of evolutionary processes. Conservation decisions depend on precise knowledge of the taxonomy and geographic distribution of species. Given such a premise, we proposed to research the diversity of Diptera of the Brazilian western arc of Amazon, Cerrado, and Pantanal in the states of Mato Grosso, Mato Grosso do Sul, and Rondônia. Three important biomes of the South American continent characterize these Brazilian states: Amazon forest, Cerrado (Brazilian Savannah), and Pantanal. Besides their ecological relevance, these biomes historically lack intensive entomological surveys. Therefore, they are much underrepresented in the Brazilian natural history collections and in the scientific literature, which is further aggravated by the fact that these areas are being exponentially and rapidly converted to commercial lands. Our project involved over 90 collaborators from 24 different Brazilian institutions and one from Colombia among researchers, postdocs, graduate and undergraduate students, and technicians. We processed and analyzed nearly 300,000 specimens from ~60 families of Diptera collected with a large variety of methods in the sampled areas. Here, we provide a detailed overview of the genera and species diversity of 41 families treated. Our results point to a total of 2,130 species and 514 genera compiled and identified for the three states altogether, with an increase of 41% and 29% in the numbers of species and genera known for the three states combined, respectively. Overall, the 10 most species-rich families were Tachinidae, Cecidomyiidae, Tabanidae, Psychodidae, Sarcophagidae, Stratiomyidae, Bombyliidae, Syrphidae, Tephritidae, and Asilidae. The 10 most diverse in the number of genera were Tachinidae, Stratiomyidae, Asilidae, Mycetophilidae, Syrphidae, Tabanidae, Muscidae, Dolichopodidae, Sarcophagidae, and Chloropidae. So far, 111 scientific papers were published regarding taxonomic, phylogenetic, and biogeographical aspects of the studied families, with the description of 101 new species and three new genera. We expect that additional publications will result from this investigation because several specimens are now curated and being researched by specialists. SISBIOTABRASIL SISBIOTA BRASIL threeyear year multimilliondollar multimillion dollar endangeredunderstudied endangered understudied Brazil flora processes premise Sul Rondônia forest Savannah, Savannah , Savannah) relevance surveys Therefore literature lands 9 2 researchers postdocs students technicians 300000 300 000 300,00 60 ~6 Here 4 treated 2130 130 2,13 51 altogether 29 combined respectively Overall 1 speciesrich rich Tachinidae Cecidomyiidae Tabanidae Psychodidae Sarcophagidae Stratiomyidae Bombyliidae Syrphidae Tephritidae Asilidae Mycetophilidae Muscidae Dolichopodidae Chloropidae far 11 taxonomic phylogenetic specialists 30000 30 00 300,0 6 ~ 213 13 2,1 5 3000 3 0 300, 21 2,

https://doi.org/10.1590/1806-9665-rbent-2023-0051

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary Sjögren syndrome: results of an epidemiologic systematic review/ meta-analysis and a consensus guideline from the Brazilian society of rheumatology (hepatic, gastrointestinal and pancreatic)
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Trevisani, Virginia Fernandes Moça

; Pinheiro, Aysa César

; Fialho, Sonia Cristina de Magalhães Souza

; Fernandes, Marilena Leal Mesquita Silvestre

; Pugliesi, Alisson

; Pasoto, Sandra Gofinet

; Lopes, Maria Lucia Lemos

; Guedes, Lissiane Karine Noronha

; Miyamoto, Samira Tatiyama

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lúcia Euzébio

; Brito, Danielle Christinne Soares Egypto de

; Libório-Kimura, Tatiana Nayara

; Santos, Maria Carmen Lopes Ferreira Silva

; Cantali, Diego Ustárroz

; Gennari, Juliana D.’Agostino

; Capobianco, Karina Gatz

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha, Aline Pereira da

; Rocha Filho, César Ramos

; Oliveira, Fabiola Reis

; Valim, Valeria

Advances in Rheumatology

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2022, Volume 62 elocation 35

Resumo: En | Texto: En | PDF: En

Abstract Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, some systemic manifestations, mainly liver, gastrointestinal, and pancreatic are not routinely evaluated. To address these manifestations, the Sjögren's Syndrome Committee of the Brazilian Society of Rheumatology conducted a broad systematic review of the literature on studies investigating prevalence and diagnosis of these symptoms in Sjogren´s patients and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. This is the second part of this guideline, providing 6 recommendations for liver, gastrointestinal, and pancreatic care of SS patients.

https://doi.org/10.1186/s42358-022-00267-y

Recommendations for evaluation and diagnosis of extra-glandular manifestations of primary sjogren syndrome: results of an epidemiologic systematic review/ meta-analysis and a consensus guideline from the Brazilian Society of Rheumatology (articular, pulmonary and renal)
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Trevisani, Virginia Fernandes Moça

; Pugliesi, Alisson

; Pasoto, Sandra Gofinet

; Lopes, Maria Lucia Lemos

; Guedes, Lissiane Karine Noronha

; Miyamoto, Samira Tatiyama

; Fernandes, Marilena Leal Mesquita Silvestre

; Fialho, Sonia Cristina de Magalhães Souza

; Pinheiro, Aysa César

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lúcia Euzébio

; Brito, Danielle Christinne Soares Egypto de

; Libório-Kimura, Tatiana Nayara

; Santos, Maria Carmen Lopes Ferreira Silva

; Cantali, Diego Ustárroz

; Gennari, Juliana D’Agostino

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha-Filho, César Ramos

; Oliveira, Fabiola Reis

; Rocha, Aline Pereira da

; Valim, Valeria

Advances in Rheumatology

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2022, Volume 62 elocation 18

Resumo: En | Texto: En | PDF: En

Abstract Sjogren’s Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, these systemic manifestations are not routinely evaluated and there is no homogenous approach to their diagnosis or evaluation. To close this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of these manifestations and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. The first part of this guideline summarizes the most important topics, and 11 recommendations are provided for the articular, pulmonary, and renal care of SS patients.

https://doi.org/10.1186/s42358-022-00248-1

2021 recommendations of the Brazilian Society of Rheumatology for the gynecological and obstetric care of patients with Sjogren’s syndrome
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Oliveira, Fabiola Reis

; Valim, Valeria

; Pasoto, Sandra Gofinet

; Fernandes, Marilena Leal Mesquita Silvestre

; Lopes, Maria Lucia Lemos

; Souza Fialho, Sonia Cristina de Magalhães

; Pinheiro, Aysa César

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lucia Euzébio

; Brito, Danielle Christinne Soares Egypto de

; Libório, Tatiana

; Santos, Maria Carmen Lopes Ferreira Silva

; Tanure, Leandro

; Gennari, Juliana DAgostino

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Rocha Filho, César Ramos

; Miyamoto, Samira Tatiyama

; Guedes, Lissiane Karine Noronha

; Pugliesi, Alisson

; Trevisani, Virginia Fernandes Moça

Advances in Rheumatology

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2021, Volume 61 elocation 54

Resumo: En | Texto: En | PDF: En

Abstract Sjogren’s syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs. Women with SS often experience gynecological symptoms due to the disease and need extra care regarding their sexual activity, reproductive health and during pregnancy, conditions that are not properly conducted in the clinical practice. To cover this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of symptoms, diagnosis, monitoring, prognosis, and treatment of these manifestations. A Focus Group meeting was held and included experts in the field and methodologists, based on a previously developed script, with themes related to the objective of the study. The most important topics were summarized and 11 recommendations were provided.

https://doi.org/10.1186/s42358-021-00208-1 54 downloads

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in inadvertently vaccinated healthy children
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Fernandes, Eder Gatti

; López-Lopes, Giselle Ibette Silva

; Silva, Valeria Oliveira

; Yamashiro, Rosemeire

; Madureira, Karen Cristina Rolim

; Gallo, Juliana Failde

; Lindoso, José Angelo

; Sato, Helena Keico

; de Araujo, Núbia Virginia D’Avila Limeira

; Nerger, Maria Ligia Bacciotte Ramos

; Brigido, Luis Fernando Macedo

Revista do Instituto de Medicina Tropical de São Paulo

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2021, Volume 63 elocation e83

Resumo: En | Texto: En | PDF: En

ABSTRACT Twenty-seven children aged seven months to 5 years were inadvertently vaccinated with a COVID-19 vaccine, the CoronaVac (Sinovac, China), an inactivated SARS-CoV-2 vaccine, in two different cities of Sao Paulo State, Brazil. After the event, these children were monitored by local pediatricians and serum samples were collected at the first visit and 30 days after vaccination and tested for SARS-CoV-2 S1 serology with Ortho total IgG anti-S1 protein and Cpass, an ACE2 receptor binding domain inhibition assay. Only one child had a mild symptom after vaccination, with no other adverse events documented up to the 30 days follow-up. Of 27 children tested 3-9 days after vaccination, 5 (19%) had positive serology suggesting a previous natural SARS-CoV-2 infection, with all 19 tested on day 30 after vaccination and presenting with positive tests, with an increment of antibody titers in those initially positive. A low Cpass binding inhibition was observed in the first collection in 11 seronegative cases, with high titers among those anti-S1 positive. All children showed an important increase in antibody titers on day 30. The event allowed the documentation of a robust serological response to one dose of CoronaVac in this small population of young children, with no major adverse effects. Although it was an unfortunate accident, this event may contribute with future vaccine strategies in this age group. The data suggest that CoronaVac is safe and immunogenic for children.

https://doi.org/10.1590/s1678-9946202163083

Decision-making for the treatment of occlusal caries in the Brazilian public health system
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Gomes, Catia

; Nayalle Lopes, Barbara

; Fernandes Maranhão, Valéria

; Guerra Botelho, Kátia Virginia

; Vilela Heimer, Mônica

; Elias dos Santos Junior, Valdeci

Revista Cubana de Estomatología

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Jun 2019, Volume 56 Nº 2 elocation e1686

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: Caries diagnosis errors have become a public health problem. Objective: Verify the consistency in terms of decision-making between Brazilian dentists from the country’s public health system and the International Caries Detection and Assessment System (ICDAS), and evaluate the influence of professional experience on the management of the decay. Methods: There are 80 dentists in the public health service of Recife city, Brazil. All dentists were invited to participate in this cross-sectional study. Forty dentists agreed to answer questions about their decision-making in relation to the treatment of occlusal caries in low, moderate and high-risk caries situations. The time of clinical experience, the use of methods for the assessment of caries risk and the lesion activity were also inquired about. The T-test was applied with a significance level of 5 % to compare the correlation between the International Caries Detection and Assessment System scores regarding the mean age of participants. Results: The disagreement between the dentists and the criteria used by the International Caries Detection and Assessment System for decision-making were mainly related to the sound surfaces or lesions restricted to the tooth enamel. It was thus verified that lack of consistency for the low-risk condition reached a score of 3 (32 %), while moderate (95 %) and high-risk (85 %) conditions lay at a classification code of 0. The time of professional experience was not considered to have interfered with decision-making on any scale, regardless of the risk condition of the patient (p> 0.05). Conclusions: A divergence in terms of decision-making between dentists of the public health system and the International Caries Detection and Assessment System could be observed, specifically regarding sound surfaces or surfaces with lesions restricted to the tooth enamel. Furthermore, professional experience was seen as not influencing the management of caries.

RESUMEN Introducción: Los errores de diagnóstico de caries se han convertido en un problema de salud pública. Objetivo: Verificar la concordancia de la toma de decisiones entre los dentistas brasileños del sistema de salud pública del país y el Sistema Internacional de Detección y Evaluación de Caries (ICDAS), así como evaluar la influencia de la experiencia profesional en el manejo de la caries. Métodos: De los 80 dentistas que existen en servicio público de salud en la ciudad de Recife, Brasil, todos fueron invitados a participar en este estudio transversal. Cuarenta dentistas acordaron responder sobre su toma de decisión en relación con el tratamiento de la caries oclusal en situaciones de caries de bajo, moderado y alto riesgo. El tiempo de experiencia clínica, el uso de métodos para la evaluación del riesgo de caries y la actividad de la lesión también fueron cuestionados. La prueba T, para un nivel de significancia del 5 %, fue aplicada para comparar la correlación entre los escores del Sistema Internacional de Detección y Evaluación de Caries en relación con el promedio de edad de los participantes. Resultados: El desacuerdo entre los dentistas y los criterios utilizados por el ICDAS para la toma de decisiones se concentró en los códigos de clasificación que representan superficies sanas o lesiones restringidas al esmalte de los dientes. Se verificó así que la falta de consistencia para la condición de bajo riesgo se concentró en la puntuación de 3 (32 %), mientras que las condiciones moderada (95 %) y de alto riesgo (85 %) se concentraron en los códigos de clasificación de 0. El factor tiempo de experiencia profesional no interfirió en la prevalencia de concordancia de la toma de decisión para cualquier escore, independientemente de la condición de riesgo del paciente (p> 0,05). Conclusiones: Se pudo observar una divergencia en cuanto a la toma de decisiones entre los dentistas del sistema de salud pública y el Sistema Internacional de Detección y Evaluación de Caries, específicamente con respecto a superficies sanas o superficies con lesiones restringidas al esmalte de los dientes. Además, la experiencia profesional no influyó en el manejo de la caries.

Brazilian recommendations on the safety and effectiveness of the yellow fever vaccination in patients with chronic immune-mediated inflammatory diseases
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Pileggi, Gecilmara Salviato

; Mota, Licia Maria Henrique Da

; Kakehasi, Adriana Maria

; Souza, Alexandre Wagner De

; Rocha, Aline

; Melo, Ana Karla Guedes de

; Fonte, Caroline Araujo M. da

; Bortoletto, Cecilia

; Brenol, Claiton Viegas

; Marques, Claudia Diniz Lopes

; Zaltman, Cyrla

; Borba, Eduardo Ferreira

; Reis, Enio Ribeiro

; Freire, Eutilia Andrade Medeiros

; Klumb, Evandro Mendes

; Christopoulos, Georges Basile

; Laurindo, Ieda Maria M.

; Ballalai, Isabella

; Costa, Izaias Pereira Da

; Michelin, Lessandra

; Valadares, Lilian David de Azevêdo

; Chebli, Liliana Andrade

; Lacerda, Marcus

; Toscano, Maria Amazile Ferreira

; Yazbek, Michel Alexandre

; Vieira, Rejane Maria R. De Abreu

; Magalhães, Renata

; Kfouri, Renato

; Richtmann, Rosana

; Merenlender, Selma Da Costa Silva

; Valim, Valeria

; Assis, Marcos Renato De

; Kowalski, Sergio Candido

; Trevisani, Virginia Fernandes Moça

Advances in Rheumatology

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2019, Volume 59 elocation 17

Resumo: En | Texto: En | PDF: En

Abstract Background: In Brazil, we are facing an alarming epidemic scenario of Yellow fever (YF), which is reaching the most populous areas of the country in unvaccinated people. Vaccination is the only effective tool to prevent YF. In special situations, such as patients with chronic immune-mediated inflammatory diseases (CIMID), undergoing immunosuppressive therapy, as a higher risk of severe adverse events may occur, assessment of the risk-benefit ratio of the yellow fever vaccine (YFV) should be performed on an individual level. Main body of the abstract: Faced with the scarcity of specific orientation on YFV for this special group of patients, the Brazilian Rheumatology Society (BRS) endorsed a project aiming the development of individualized YFV recommendations for patients with CIMID, guided by questions addressed by both medical professionals and patients, followed an internationally validated methodology (GIN-McMaster Guideline Development). Firstly, a systematic review was carried out and an expert panel formed to take part of the decision process, comprising BRS clinical practitioners, as well as individuals from the Brazilian Dermatology Society (BDS), Brazilian Inflammatory Bowel Diseases Study Group (GEDIIB), and specialists on infectious diseases and vaccination (from Tropical Medicine, Infectious Diseases and Immunizations National Societies); in addition, two representatives of patient groups were included as members of the panel. When the quality of the evidence was low or there was a lack of evidence to determine the recommendations, the decisions were based on the expert opinion panel and a Delphi approach was performed. A recommendation was accepted upon achieving ≥80% agreement among the panel, including the patient representatives. As a result, eight recommendations were developed regarding the safety of YFV in patients with CIMID, considering the immunosuppression degree conferred by the treatment used. It was not possible to establish recommendations on the effectiveness of YFV in these patients as there is no consistent evidence to support these recommendations. Conclusion: This paper approaches a real need, assessed by clinicians and patient care groups, to address specific questions on the management of YFV in patients with CIMID living or traveling to YF endemic areas, involving specialists from many areas together with patients, and might have global applicability, contributing to and supporting vaccination practices. We recommended a shared decision-making approach on taking or not the YFV.

https://doi.org/10.1186/s42358-019-0056-x 1111 downloads

Recommendations from the Brazilian society of rheumatology for the diagnosis of Sjögren's syndrome (Part I): glandular manifestations (systematic review)
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Trevisani, Virginia Fernandes Moça

; Pasoto, Sandra Gofinet

; Fernandes, Marilena Leal Mesquita Silvestre

; Lopes, Maria Lucia Lemos

; Fialho, Sonia Cristina de Magalhães Souza

; Pinheiro, Aysa César

; Santos, Laura Caldas dos

; Appenzeller, Simone

; Fidelix, Tania

; Ribeiro, Sandra Lucia Euzébio

; Brito, Danielle Christinne Soares Egypto de

; Libório, Tatiana

; Santos, Maria Carmen Lopes Ferreira Silva

; Tanure, Leandro

; Gennari, Juliana D Agostino

; Civile, Vinicius Tassoni

; Pinto, Ana Carolina Pereira Nunes

; Oliveira, Fabiola Reis

; Sousa, Jaqueline Martins de

; Miyamoto, Samira Tatiyama

; Valim, Valeria

Advances in Rheumatology

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2019, Volume 59 elocation 58

Resumo: En | Texto: En | PDF: En

Abstract Background: Primary Sjögren's syndrome (pSS) is a systemic immune-mediated disease whose main characteristic is exocrine gland inflammation and, subsequent reduction in tear and saliva production. A delayed diagnosis is common due to the nonspecific clinical manifestations of disease. The aim of the present study was to develop recommendations for the diagnosis of glandular manifestations of pSS based on evidence and expert opinion. Main body of the abstract: We conducted a systematic literature review to retrieve the best evidence available on the accuracy of diagnostic tests for pSS. We also held two in-person meetings with experts (rheumatologists, pathologists, ophthalmologists and dentists) to establish their level of agreement using the Delphi method. Ultimately, we generated 18 recommendations that aim to facilitate the diagnosis of the glandular manifestations of pSS. Conclusion: The diagnosis of glandular manifestations of pSS is complex and multidisciplinary. It requires specific knowledge in the field of ophthalmology, immunology, pathology and imaging, making it compulsory for the rheumatologist to work with professionals from these different areas in order to improve accuracy and early diagnosis. Glandular dysfunction tests, ANA, RF, Anti-Ro, protein electrophoresis, urinalysis, blood count, C-Reactive protein, complement, testing for syphilis and viruses (HCV, HIV) and SGUS should be investigated when dryness or systemic manifestation are present. Minor salivary gland biopsy is recommended for all anti-Ro negative or incomplete criteria cases.

https://doi.org/10.1186/s42358-019-0102-8 878 downloads

10.

Recomendações para o tratamento da síndrome de Sjögren
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Valim, Valéria

; Trevisani, Virgínia Fernandes Moça

; Pasoto, Sandra Gofinet

; Serrano, Erica Vieira

; Ribeiro, Sandra Lúcia Euzébio

; Fidelix, Tania Sales de Alencar

; Vilela, Verônica Silva

; Prado, Leandro Lara do

; Tanure, Leandro Augusto

; Libório-Kimura, Tatiana Nayara

; Brito Filho, Odvaldo Honor de

; Barros, Liliana Aparecida Pimenta de

; Miyamoto, Samira Tatiyama

; Lourenço, Silvia Vanessa

; Santos, Maria Carmen Lopes Ferreira Silva

; Vieira, Luis Antonio

; Adán, Consuelo Bueno Diniz

; Bernardo, Wanderley Marques

Revista Brasileira de Reumatologia

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Out 2015, Volume 55 Nº 5 Páginas 446 - 457

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMOAs recomendações propostas pela Comissão de Síndrome de Sjögren da Sociedade Brasileira de Reumatologia para tratamento da síndrome de Sjögren foram baseadas em uma revisão sistemática da literatura nas bases de dados Medline (PubMed) e Cochrane até outubro de 2014 e opinião de especialistas na ausência de artigos sobre o assunto. Foram incluídos 131 artigos classificados de acordo com Oxford & Grade. Essas recomendações foram elaboradas com o objetivo de orientar o manejo adequado e facilitar o acesso aos tratamentos para aqueles pacientes com adequada indicação de recebê-los, considerando o contexto socioeconômico brasileiro e os medicamentos disponíveis no país.

ABSTRACTThe recommendations proposed by the Sjögren's Syndrome Committee of the Brazilian Society of Rheumatology for the treatment of Sjögren's syndrome were based on a systematic review of literature in Medline (PubMed) and the Cochrane databases until October 2014 and on expert opinion in the absence of studies on the subject. 131 articles classified according to Oxford & Grade were included. These recommendations were developed in order to guide the management and facilitate the access to treatment for those patients with an appropriate indication, considering the Brazilian socioeconomic context and pharmacological agents available in this country.

https://doi.org/10.1016/j.rbr.2015.07.004 60323 downloads

11.

Contratos, convênios e parcerias na gestão da educação em municípios de regiões metropolitanas: tensões e desafios
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Martins, Angela Maria

; Pimenta, Cláudia Oliveira

; Lopes, Valéria Virgínia

Educação & Sociedade

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- Sobre o periódico
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Dez 2013, Volume 34 Nº 125 Páginas 1049 - 1074

Resumo: Pt En Fr | Texto: Pt En Fr | PDF: Pt | PDF: En | PDF: Fr

Este artigo discute resultados de estudo-piloto que apresentava como propósito examinar a capacidade institucional de dez municípios paulistas na gestão da educação básica. Na investigação original, os dados foram sistematizados e agregados em torno de cinco categorias de análise, a saber: estrutura e funcionamento do sistema/rede de ensino; gestão de pessoas; gestão pedagógica; financiamento e, finalmente, a quinta categoria - programas e projetos - estruturada com base na análise da realização de convênios, contratos e parcerias com os governos, federal e estadual; outros municípios; o setor privado lucrativo e não lucrativo; universidades; outras secretarias e/ou órgãos da administração municipal. Foram considerados também os programas e projetos implementados por iniciativa da própria Secretaria/Diretoria de educação e de suas equipes. Este artigo focará estas últimas questões.

This article discusses the results of a pilot study which aimed at examining the institutional capability of ten cities in the state of São Paulo, Brazil in managing basic education. In the original investigation, the data were systematized and brought together into five categories: structure and functioning of the teaching system/network; human resources management; pedagogical management; financing and programs and projects. The last category was structured according to criteria based on the analysis of contracts, grants and partnerships with the federal and state governments, other municipalities, the private sector (for-profit or non-profit), universities, other secretariats and/or organs belonging to the municipal administration. Programs and projects implemented by the own Education Secretariat/board and their staff were also considered. This article will focus on the latter aspects.

Cet article discute les résultats de l'étude-pilote qui présentait comme intention examiner la capacité institutionnelle de dix villes de l'Etat de São Paulo dans la gestion de l'enseignement de base. Dans la recherche originale, les données ont été systématisées et ajoutées autour de cinq catégories d'analyse, à savoir: structure et fonctionnement du système/réseau d'enseignement; gestion du personnel; gestion pédagogique; financement et, finalement, cinquième catégorie - programmes et projets - structurée sur l'analyse de la réalisation d'accords, de contrats et de partenariats avec les gouvernements fédéral et de l'état; autres villes; le secteur privé lucratif et non lucratif; universités; autres secrétariats et/ou des agences de l'administration de la municipalité. Aussi, ont été considérés les programmes et les projets mis en œuvre par l'initiative de la Direction et du Secrétariat d'éducation et de leurs équipes. Cet article met en évidence ces dernières questions.

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12.

A capacidade institucional de municípios paulistas na gestão da educação básica
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Martins, Angela Maria

; Pimenta, Cláudia Oliveira

; Fernandes, Fabiana Silva

; Novaes, Gláucia Torres Franco

; Lopes, Valéria Virgínia

Cadernos de Pesquisa

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Dez 2013, Volume 43 Nº 150 Páginas 812 - 8350

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Este artigo tem como propósito apresentar e discutir parte de resultados de pesquisa que se propôs a analisar a capacidade institucional de municípios paulistas no planejamento de políticas educacionais, com base nos aspectos que se referem à estrutura e funcionamento de sistemas/redes de ensino, à gestão de pessoas e à gestão pedagógica. O estudo-piloto foi realizado em dez municípios de três Regiões Metropolitanas do Estado de São Paulo. O artigo apresenta, inicialmente, diferentes visões sobre o conceito de capacidade institucional e, na sequência, analisa dados obtidos em fontes oficiais e em entrevistas realizadas nos municípios pesquisados.

This article presents and discusses part of the results of the research intended to examine the institutional capacity of São Paulo state municipalities regarding education policy planning, based on the aspects pertaining to: structure and operation of school systems; human resource management; pedagogical approach. The pilot study was carried out in ten municipalities of three metropolitan areas of the State of São Paulo. Initially, it presents different views on the concept of institutional capacity, followed by an analysis of the data obtained from official sources and in interviews done at the chosen municipalities.

Este artículo tiene el propósito de presentar y discutir parte de los resultados de la investigación que se propuso a analizar la capacidad institucional de los municipios de São Paulo para planificar políticas educativas en base a los aspectos que se refieren a la estructura y al funcionamiento de sistemas/redes de enseñanza, a la gestión de personas y a la gestión pedagógica. El estudio-piloto se llevó a cabo en diez municipios de tres Regiones Metropolitanas del Estado de São Paulo. El artículo presenta inicialmente distintas visiones sobre el concepto de capacidad institucional y, a continuación, analiza datos que se obtuvieron en fuentes oficiales y en entrevistas realizadas en los municipios investigados.

2717 downloads

13.

Analysis of the chemical composition of the essential oils extracted from Lippia lacunosa Mart. & Schauer and Lippia rotundifolia Cham. (Verbenaceae) by gas chromatography and gas chromatography-mass spectrometry
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Leitão, Suzana G.

; Oliveira, Danilo R. de

; Sülsen, Valeria

; Martino, Virginia

; Barbosa, Ymira Galico

; Bizzo, Humberto R.

; Lopes, Daíse

; Viccini, Lyderson F.

; Salimena, Fatima R. G.

; Peixoto, Paulo H. P.

; Leitão, Gilda G.

Journal of the Brazilian Chemical Society

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2008, Volume 19 Nº 7 Páginas 1388 - 1393

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Lippia lacunosa e L. rotundifolia são duas espécies brasileiras que formam um complexo de difícil delimitação taxonômica. A composição química do óleo essencial das folhas e flores dessas plantas foi investigada por cromatografia com fase gasosa (CG) e por cromatografia com fase gasosa acoplada à espectrometria de massas (CG-EM). Principais constituintes dos óleos essenciais de L. lacunosa (flores e folhas): mirceno (14,7% e 11,9%), mircenona (45,2% e 64,2%), Z-ocimenona (5,7% e 5,2%), e E-ocimenona (14,7% e 4,1%), respectivamente; L. rotundifolia (flores e folhas): a-pineno (8,7% e 1,8%), mirceno (5,1% e 3,6%), limoneno (26,0% e 7,9 %), cis-pinocanfona (4,5% e 3,1%) e mirtenal (22,3% e 16,7%), respectivamente. Os óleos essenciais de L. lacunosa apresentaram um forte e agradável aroma de manga, que foi relacionado à presença de mirceno e mircenona. Diferenças fundamentais na composição química de seus óleos essenciais podem representar uma poderosa ferramenta na classificação botânica das espécies.

Lippia lacunosa and L. rotundifolia (Verbenaceae) are two Brazilian species of complex taxonomic delimitation. The composition of the essential oils from leaves and flowers of these plants was investigated by gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC-MS) analysis. The major components of the essential oils of flowers and leaves of L. lacunosa were: myrcene (14.7% and 11.9%), myrcenone (45.2% and 64.2%), Z-ocimenone (5.7% and 5.2%), and E-ocimenone (14.7% and 4.1%), respectively; whereas in L. rotundifolia (flowers and leaves) were a-pinene (8.7% and 1.8%), myrcene (5.1% and 3.6%), limonene (26.0% and 7.9 %), cis-pinocamphone (4.5% and 3.1%) and myrtenal (22.3% and 16.7%), respectively. The essential oils from L. lacunosa exhibited a strong and pleasant mango aroma, which was related to the presence of myrcene and myrcenone. The marked differences in the chemical composition of their essential oils may represent a powerful tool for the botanical classification.

6954 downloads

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