Abstract Objective: To report the case of a patient with Glanzmann’s thrombasthenia who receives management with platelet transfusion with activated factor VII and a literature review regarding the treatment and prognosis of this pathology during pregnancy. Method: We present the case of a 27 year old patient with Glanzmann’s thrombasthenia and a 33-week pregnancy, with a cesarean section at term without complications. Medline databases were searched via PubMed, Lilacs, SciELO and ScienceDirect; case reports, case series and bibliographic reviews were included until 2021. Results: A total of 21 articles were found, with 23 reported cases; the pregnancies occurred between the third and fourth decades of life, the majority being patients with anti-platelet antigen antibodies in 43.4% of the cases. The main management was with platelet transfusion. Conclusions: Glanzmann’s thrombasthenia during pregnancy is rare and is associated with hemorrhagic events. The presence of anti-platelet antigen antibodies conditions management with a higher risk of perinatal complications. It does not have a unified therapeutic approach, with platelet transfusion being the management of choice and activated factor VII as second line.

Resumen Objetivo: Reportar el caso de una paciente con trombastenia de Glanzmann que recibe manejo con transfusión de plaquetas con factor VII activado y realizar una revisión de la literatura referente al tratamiento y el pronóstico de esta patología durante la gestación. Método: Se presenta el caso de una paciente de 27 años con trombastenia de Glanzmann y embarazo de 33 semanas, con cesárea al término sin complicaciones. Se realizó una búsqueda en las bases de datos Medline vía PubMed, Lilacs, SciELO y ScienceDirect; se incluyeron reportes de caso, series de casos y revisiones bibliográficas hasta 2021. Resultados: Se encontraron 21 artículos, con 23 casos reportados. Los embarazos se presentaron entre la tercera y la cuarta décadas de la vida, siendo la mayoría pacientes con anticuerpos frente a antígenos plaquetarios (43,4% de los casos). El principal manejo fue con transfusión plaquetaria. Conclusiones: La trombastenia de Glanzmann durante el embarazo es infrecuente y se asocia a eventos hemorrágicos. La presencia de anticuerpos frente a antígenos plaquetarios condiciona el manejo con mayor riesgo de complicaciones perinatales. No tiene un enfoque terapéutico unificado, siendo el de elección la transfusión de plaquetas y como segunda línea el factor VII activado.

Abstract: The aim of the study was to evaluate how the association of solvents (tetrahydrofuran [THF], dimethyl sulfoxide [DMSO], ethanol [ET] or acetone [ACT]) with experimental dental adhesives affects selected properties of experimental dental adhesives and dentin bond durability. Six adhesive combinations were prepared containing: 30 % ET, 30 % ACT, 30 % THF, 28 % ET + 2 % DMSO (ET+DMSO), 15 % ethanol + 15 % THF (ET+THF), or 28 % THF + 2 % DMSO (THF+DMSO). Thirty-six molars (n = 6) were cut to expose the coronary dentin, and were randomly divided according to the adhesives. They were restored, and then cut into resindentin sticks (1 mm²), and stored in distilled water for 24 h or 6 months, until conducting the microtensile bond strength and nanoleakage tests. Other experiments performed with adhesives included viscosity assessment using a rheometer, and degree of conversion using Fourier-transform infrared spectroscopy (FTIR). The data were analyzed statistically using two-way ANOVA and Tukey’s test (p < 0.05). The adhesive formulated exclusively with THF showed the highest viscosity, followed by ET+THF, which obtained the highest degree of conversion compared to ET, and THF alone. ET+DMSO obtained the highest 24-h and aged bond strengths (p < 0.05). ET+THF increased the nanoleakage slightly after 6 months, but attained the only gap-free adhesive interface among all the groups. The combination of alternative solvents, particularly THF, with conventional ones (ET) has improved chemical properties, and the dentin bonding of experimental simplified adhesives.

Aedes aegypti is the main vector of three neglected tropical diseases: dengue, zika and chikungunya. Dengue is under surveillance by health organizations worldwide due to the risk of epidemics. Since there is no specific treatment for dengue, most studies have focused on preventing the reproduction and/or development of the mosquitoes. We studied the larvicidal activity of five phosphates and phosphorothioates derived from cardol, one of the four main components of cashew nut shell liquid (Anacardium occidentale L.), at different concentrations. The organophosphorothioate derivatives were tested for their in vitro inhibitory potential against acetylcholinesterase (AChE). One compound, Cdl.i-dPS (median lethal concentration (LC50) = 0.8 ppm), was four times more efficient compared to an important commercial larvicide, Temephos (LC50 = 3.2 ppm), and showed greater AChE inhibition than its monosubstituted analogue and Temephos.

RESUMO O trabalho apresenta o potencial energético de blendas de bagaço de cana-de-açúcar e podas de mangueira e cajueiro. As amostras foram caracterizadas por meio da determinação do poder calorífico superior, densidade, análise imediata (umidade, cinzas, matéria volátil e carbono fixo), análise elementar e termogravimetria. As misturas foram preparadas com diferentes frações em massa. Após avaliação qualitativa e quantitativa das amostras verificou-se quais blendas apresentaram os melhores resultados e, em seguida, os briquetes foram produzidos. As misturas de bagaço de cana:poda de mangueira (frações 50%: 50%), bagaço de cana:poda de cajueiro (frações 50%: 50%) e bagaço de cana:poda de cajueiro:poda de mangueira (frações 50%: 25%: 25%) foram utilizadas na produção dos briquetes. A última parte do trabalho apresenta a diferença entre o potencial energético dos briquetes e do bagaço de cana. A densidade energética dos briquetes de bagaço de cana-de-açúcar e poda de mangueira aumentou de 1,79 para 13,55 (kJ cm-3), em relação ao material não compactado. Os briquetes com poda de cajueiro variaram de 1,97 a 12,75 (kJ cm-3) e os briquetes de bagaço de cana:poda de cajueiro:poda de mangueira variaram de 2,46 a 12,18 (kJ cm-3). O briquete de bagaço de cana apresentou variação de 1,25 para 13,22 (kJ cm-3). A investigação do potencial energético de bioprodutos agrícolas (podas de mangueira e cajueiro) em mistura com bagaço de cana-de-açúcar, apresenta à indústria sucroalcooleira uma nova possibilidade de reutilização de resíduos de biomassa para obtenção de energia.

ABSTRACT The work shows the energy potential of blends of sugarcane bagasse with the mango tree and cashew tree's pruning. The samples were characterized by gross calorific value, density, proximate analysis (moisture, ash, volatile matter and fixed carbon), elemental analysis and thermogravimetry. The blends were prepared with different mass fractions. After evaluation of the samples qualitative and quantitative analyses, it was verified which blends showed the better results and then the briquettes were prepared. The blends of sugarcane bagasse:mango tree pruning (fractions 50%:50%), sugarcane bagasse:cashew tree pruning (fractions 50%:50%), and sugarcane bagasse:cashew tree pruning:mango tree pruning (fractions 50%:25%:25%) were used to the briquettes production. The last part of the work shows the difference between the energy potential of the briquettes and the sugarcane bagasse. The energy density of the briquettes of sugarcane bagasse and mango tree pruning increased from 1.79 to 13.55 (kJ cm-3), in relation to the uncompacted material. The cashew tree pruning's briquettes varied from 1.97 to 12.75 (kJ cm-3), and the briquettes of sugarcane bagasse:cashew tree pruning:mango tree pruning varied from 2.46 to 12.18 (kJ cm-3). The sugarcane bagasse briquette showed a variation of 1.25 to 13.22 (kJ cm-3). The investigation of the energy potential of agricultural bioproducts (mango and cashew tree's pruning) in mixture with sugarcane bagasse presents to the sugar-alcohol industry a new possibility of reuse of biomass waste to obtain of energy.

New asymmetric cardanol-based porphyrins, free-base and coordinated with Ni, Co and Cu, were synthesized and completely characterized as A3B type. Such porphyrins were obtained aiming improved solubility in polar solvents due insertion of an -OH phenolic group. Their thermal and dielectric properties were also evaluated. Changes in the synthetic route reduced the reaction time and improved the yields of the aldehyde precursor obtainment. Electronic absorption spectra of the new porphyrins in CH2Cl2, EtOH and acetone, indicated a decrease in the ε (molar absorptivity) values with increasing solvent polarity, except for the nickel complex which, in acetone, showed a slight increase of 2% in the ε value. The dielectric measurements showed that the conductivity (σ) and the loss tangent (tan δ) increased with frequency, but the permittivity (ε') decreased. The results showed that the coordination of the porphyrin promoted a significant change in thermal and dielectric properties, specially for to the Ni-complex compound, which presented the best dielectric properties with interesting values of permittivity and loss tangent at 100 MHz (19.46 and 0.011 a.u., respectively).

Abstract A growing global trend for maximum use of natural resources through new processes and products has enhanced studies and exploration of renewable natural materials. In this study, cardanol, a component of the cashew nut shell liquid (CNSL), was used as a building block for the development of a thermosetting matrix, which was reinforced by raw and modified sponge gourd fibers (Luffa cylindrica). DSC and TG results showed that among biocomposites, the one reinforced by sponge gourd fibers treated with NaOH 10 wt% (BF10) had the highest thermal stability, besides the best performance in the Tensile testing, showing good incorporation, dispersion, and adhesion to polymer matrix, observed by SEM. After 80 days of simulated soil experiments, it has been discovered that the presence of treated fiber allowed better biodegradability behavior to biocomposites. The biobased thermoset plastic and biocomposites showed a good potential to several applications, such as manufacturing of articles for furniture and automotive industries, especially BF10.

The new millennium is marked by a growing search for renewable fuels and alternative raw materials from biomass in the petrochemicals industry. However, there are many challenges to overcome regarding technological and human resources aspects. In this scenario, cashew nut oil, which is rich in natural phenols, is considered to be very promising for the development of synthetic and functional products and as a feedstock for production of fine chemicals and a wide variety of new materials.