Nitroaromatic acids, ubiquitous intermediates in nitro compounds, find broad applications in pharmaceuticals and fine chemical industries, yet their safety often receives inadequate attention. This paper investigates the thermal decomposition process of three isomers of nitrobenzoic acid using differential scanning calorimetry (DSC) and thermogravimetric analysis (TG), complemented by calculations of the apparent activation energy using typical kinetic methods. The reaction type was verified using a nonlinear fitting method. Thermal safety parameters including the time to maximum rate (TMR), critical temperature of self-acceleration (TCL), and thermal risk index (TRI) were employed to elucidate the thermal hazards. The thermal decomposition mechanism was further explained using density functional theory (DFT) methods, focusing on the Mayer bond order. The findings revealed that the average apparent activation energies for p-nitrobenzoic acid (PNBA), m-nitrobenzoic acid (MNBA), and o-nitrobenzoic acid (ONBA) were 157.00, 203.43, and 131.31 kJ mol-1, respectively. A single n-order reaction characterized the thermal decomposition process. The TMR and TCL parameters indicated a decomposition tendency at high temperatures, with the thermal stability at elevated temperatures following the order: PNBA < ONBA < MNBA. The TRI parameter indicates the danger level of the nitrobenzoic acids. The thermal decomposition mechanism was elucidated using Mayer bond energies, offering valuable insights into storage and transportation, and contributing to developing predictive models for thermal characteristics.

SUMMARY: To measure and study the anatomical morphological data of the lumbar 5 to sacral 1 intervertebral space with the aid of CT and design an anatomical anterior lumbosacral 3D printed integrated interbody fusion for the treatment of degenerative lumbosacral spine diseases. 100 adults (50 of each sex) who underwent CT examination of the lumbar spine in our hospital were selected, and their lumbar 5 to sacral 1 intervertebral space anatomical data were measured, including the anterior lumbar convexity angle, different sagittal and coronal heights, and the sagittal and coronal diameters of the superior and inferior endplates. The measured data were also statistically analyzed, and morphological design and study of the 3D printed integrated fusion device in the anterior lumbosacral spine was performed by applying computer software. When comparing the coronal and sagittal diameters of the superior and inferior endplates from lumbar 5 to sacral 1, the differences were statistically greater in men than in women (P<0.001). The differences were not statistically significant when comparing the anterior convexity angle of the lumbosacral space (P>0.001). When comparing the height at different positions in the median sagittal plane, both males and females showed an anterior high and posterior low pattern. In the coronal plane, both males and females showed the highest height in the middle position (P<0.001), and there was no statistically significant difference between the left and the right height (P>0.001). CT can measure the anatomical data of the lumbosacral spinal hiatus more accurately. The 3D-printed anterior integrated fusion device of the lumbosacral spine designed according to the analysis of the data results is more in line with the anatomical structure of the lumbosacral spine, fits well with the superior and inferior endplates, and effectively restores the height and anterior convexity angle of the lumbosacral space.

RESUMEN: El objetivo de este trabajo fue medir y estudiar los datos morfológicos anatómicos del espacio intervertebral lumbar 5 a sacro 1 con la ayuda de TC y diseñar una fusión intersomática integrada anatómica lumbosacra anterior impresa en 3D para el tratamiento de enfermedades degenerativas de la columna lumbosacra. Se seleccionaron en nuestro hospital 100 adultos (50 de cada sexo) que se sometieron a un examen de TC de la columna lumbar y se midieron los datos anatómicos del espacio intervertebral lumbar 5 al sacro 1, incluyendo el ángulo de la convexidad lumbar anterior, diferentes alturas sagital y coronal, y los diámetros sagital y coronal de las placas terminales superior e inferior. Los datos medidos también se analizaron estadísticamente y se realizó el diseño morfológico y el estudio del dispositivo de fusión integrado impreso en 3D en la columna lumbosacra anterior mediante la aplicación de software informático. Al comparar los diámetros coronal y sagital de las placas terminales superior e inferior desde lumbar 5 hasta sacro 1, las diferencias fueron estadísticamente mayores en hombres que en mujeres (P <0,001). Las diferencias no fueron estadísticamente significativas al comparar el ángulo de convexidad anterior del espacio lumbosacro (P>0,001). Al comparar la altura en diferentes posiciones en el plano mediano, tanto hombres como mujeres mostraron un patrón anterior alto y posterior bajo. En el plano coronal, tanto hombres como mujeres mostraron la altura más alta en la posición media (P<0,001), y no hubo diferencia estadísticamente significativa entre las alturas izquierda y derecha (P>0,001). La TC puede medir los datos anatómicos del hiato espinal lumbosacro con mayor precisión. El dispositivo de fusión anterior integrado impreso en 3D de la columna lumbosacra diseñado de acuerdo con el análisis de los resultados de los datos está más en línea con la estructura anatómica de la columna lumbosacra, se adapta bien a las placas terminales superior e inferior y restaura eficazmente la altura y la parte anterior del ángulo de convexidad del espacio lumbosacro.

SUMMARY: Esophageal cancer is one of the most aggressive gastrointestinal cancers. Invasion and metastasis are the main causes of poor prognosis of esophageal cancer. SPRY2 has been reported to exert promoting effects in human cancers, which controls signal pathways including PI3K/AKT and MAPKs. However, the expression of SPRY2 in esophageal squamous cell carcinoma (ESCC) and its underlying mechanism remain unclear. In the present study, we aimed to investigate the detailed role of SPRY2 in the regulation of cell proliferation, invasion and ERK/AKT signaling pathway in ESCC. It was identified that the expression level of SPRY2 in ESCC was remarkably decreased compared with normal tissues, and it was related to clinicopathologic features and prognosis ESCC patients. The upregulation of SPRY2 expression notably inhibited the proliferation, migration and invasion of Eca-109 cells. In addition, the activity of ERK /AKT signaling was also suppressed by the SPRY2 upregulation in Eca-109 cells. Our study suggests that overexpression of SPRY2 suppress cancer cell proliferation and invasion of by through suppression of the ERK/AKT signaling pathways in ESCC. Therefore, SPRY2 may be a promising prognostic marker and therapeutic target for ESCC.

RESUMEN: El cáncer de esófago es uno de los cánceres gastrointestinales más agresivos. La invasión y la metástasis son las principales causas de mal pronóstico del cáncer de esófago. Se ha informado que SPRY2 ejerce efectos promotores en los cánceres humanos, que controla las vías de señales, incluidas PI3K/AKT y MAPK. Sin embargo, la expresión de SPRY2 en el carcinoma de células escamosas de esófago (ESCC) y su mecanismo subyacente aún no están claros. En el presente estudio, nuestro objetivo fue investigar el papel detallado de SPRY2 en la regulación de la proliferación celular, la invasión y la vía de señalización ERK/AKT en ESCC. Se identificó que el nivel de expresión de SPRY2 en ESCC estaba notablemente disminuido en comparación con los tejidos normales, y estaba relacionado con las características clínico-patológicas y el pronóstico de los pacientes con ESCC. La regulación positiva de la expresión de SPRY2 inhibió notablemente la proliferación, migración e invasión de células Eca-109. Además, la actividad de la señalización de ERK/AKT también fue suprimida por la regulación positiva de SPRY2 en las células Eca-109. Nuestro estudio sugiere que la sobreexpresión de SPRY2 suprime la proliferación y la invasión de células cancerosas mediante la supresión de las vías de señalización ERK/AKT en ESCC. Por lo tanto, SPRY2 puede ser un marcador de pronóstico prometedor y un objetivo terapéutico para la ESCC.

SUMMARY: The objective of this study was to investigate the therapeutic wound healing potential and molecular mechanisms of shikonin as small molecules in vitro. A mouse burn model was used to explore the potential therapeutic effect of shikonin; we traced proliferating cells in vivo to locate the active area of skin cell proliferation. Through the results of conventional pathological staining, we found that shikonin has a good effect on the treatment of burned skin and promoted the normal distribution of skin keratin at the damaged site. At the same time, shikonin also promoted the proliferation of skin cells at the damaged site; importantly, we found a significant increase in the number of fibroblasts at the damaged site treated with shikonin. Most importantly, shikonin promotes fibroblasts to repair skin wounds by regulating the PI3K/AKT signaling pathway. This study shows that shikonin can effectively promote the proliferation of skin cell, and local injection of fibroblasts in burned skin can play a certain therapeutic role.

RESUMEN: El objetivo de este trabajo fue investigar el potencial terapéutico de cicatrización de heridas y los mecanismos moleculares de la shikonina como moléculas pequeñas in vitro. Se utilizó un modelo de quemaduras en ratones para explorar el posible efecto terapéutico de la shikonina; Rastreamos las células en proliferación in vivo para localizar el área activa de proliferación de células de la piel. A través de los resultados de la tinción para patología convencional, encontramos que la shikonina tiene un buen efecto en el tratamiento de la piel quemada y promueve la distribución normal de la queratina de la piel en el sitio dañado. Al mismo tiempo, la shikonina también promovió la proliferación de células de la piel en el sitio dañado. Es importante destacar que encontramos un aumento significativo en la cantidad de fibroblastos en el sitio dañado tratado con shikonina. Lo más importante es que la shikonina promueve la función reparadora de fibroblastos en las heridas de la piel regulando la vía de señalización PI3K/ AKT. Este estudio muestra que la shikonina puede promover eficazmente la proliferación de células de la piel y que la inyección local de fibroblastos en la piel quemada puede desempeñar un cierto papel terapéutico.

Abstract Background As a common disabling disease, irreversible neuronal death due to spinal cord injury (SCI) is the root cause of functional impairment; however, the capacity for neuronal regeneration in the developing spinal cord tissue is limited. Therefore, there is an urgent need to investigate how defective neurons can be replenished and functionally integrated by neural regeneration; the reprogramming of intrinsic cells into functional neurons may represent an ideal solution. Methods A mouse model of transection SCI was prepared by forceps clamping, and an adeno-associated virus (AAV) carrying the transcription factors NeuroD1 and Neurogenin-2(Ngn2) was injected in situ into the spinal cord to specifically overexpress these transcription factors in astrocytes close to the injury site. 5-bromo-2´-deoxyuridine (BrdU) was subsequently injected intraperitoneally to continuously track cell regeneration, neuroblasts and immature neurons marker expression, neuronal regeneration, and glial scar regeneration. In addition, immunoprotein blotting was used to measure the levels of transforming growth factor-β (TGF-β) pathway-related protein expression. We also evaluated motor function, sensory function, and the integrity of the blood-spinal cord barrier(BSCB). Results The in situ overexpression of NeuroD1 and Ngn2 in the spinal cord was achieved by specific AAV vectors. This intervention led to a significant increase in cell regeneration and the proportion of cells with neuroblasts and immature neurons cell properties at the injury site(p < 0.0001). Immunofluorescence staining identified astrocytes with neuroblasts and immature neurons cell properties at the site of injury while neuronal marker-specific staining revealed an increased number of mature astrocytes at the injury site. Behavioral assessments showed that the intervention did not improve The BMS (Basso mouse scale) score (p = 0.0726) and gait (p > 0.05), although the treated mice had more sensory sensitivity and greater voluntary motor ability in open field than the non-intervention mice. We observed significant repair of the BSCB at the center of the injury site (p < 0.0001) and a significant improvement in glial scar proliferation. Electrophysiological assessments revealed a significant improvement in spinal nerve conduction (p < 0.0001) while immunostaining revealed that the levels of TGF-β protein at the site of injury in the intervention group were lower than control group (p = 0.0034); in addition, P70 s6 and PP2A related to the TGF-β pathway showed ascending trend (p = 0.0036, p = 0.0152 respectively). Conclusions The in situ overexpression of NeuroD1 and Ngn2 in the spinal cord after spinal cord injury can reprogram astrocytes into neurons and significantly enhance cell regeneration at the injury site. The reprogramming of astrocytes can lead to tissue repair, thus improving the reduced threshold and increasing voluntary movements. This strategy can also improve the integrity of the blood-spinal cord barrier and enhance nerve conduction function. However, the simple reprogramming of astrocytes cannot lead to significant improvements in the striding function of the lower limbs.

Abstract This study synthesized novel nano-biochar supported TiO2 composites using various methods and biochar/TiO2 ratios to effectively remove dichloroacetic acid (DCA) from swimming pool water. The hydrothermally prepared HBT-5 composite with 5 wt% biochar exhibited the highest photocatalytic activity, degrading 92.5% of DCA within 180 min under UV-vis light irradiation, outperforming pure TiO2 and HBT-1. Comprehensive characterization confirmed the strong interaction and synergistic effects between biochar and TiO2, attributing the enhanced performance to high surface area, pore volume, interfacial Ti-O-C bonding, visible light absorption, efficient charge separation, and N and O heteroatoms in biochar. The photocatalyst showed excellent reusability, maintaining 87.3% of its initial activity after three cycles. This work provides insights into designing biochar-based photocatalysts for water purification, benefiting public health and environmental protection. nanobiochar nano TiO biocharTiO2 biocharTiO biochar/TiO (DCA HBT5 HBT HBT- wt 925 92 92.5 18 UVvis UV vis irradiation HBT1. HBT1 1. 1 HBT-1 area volume TiOC Ti C bonding absorption separation reusability 873 87 3 87.3 cycles biocharbased based purification protection 9 92. 8 87.

Abstract Objective: This study mainly explores (2R,6R; 2S,6S)-HNK and its compounds whether there are antidepressant effects. Methods: Four HNK compounds were obtained from 2-(Chlorophenyl) Cyclopentylmethanone. Forced swimming test, locomotor sensitization test, and conditioned location preference test were used to screen the antidepressant activity of the synthesized target compounds. Results: In the case of 10 mg HNK treatment, compared with saline, the immobile time of mice in the HNK group, I5 group and I6 group at 1 h and 7 days had statistical significance. In the case of 10 mg HNK treatment, compared with saline, the immobile time of compound C and D groups in the glass cylinder area was significantly different. In the locomotor sensitization test, the movement distance of compound C and D groups on day 15 and day 7 mice increased significantly compared with the first day. In the conditioned place preference experiment, compound C and compound D induced conditioned place preference in mice compared with the Veh group. Conclusion: The results of the forced swimming test, locomotor sensitization test, and conditioned location preference test showed that compounds C and D may have certain anti-depressant activity. However, HNK exerts a rapid and significant antidepressant effect within 1 week, but the duration is short. Objective 2R,6R 2R6R RR 2R 6R R (2R,6R 2S,6SHNK 2S6SHNK SSHNK 2S,6S 2S 6S S effects Methods 2Chlorophenyl Chlorophenyl 2 2-(Chlorophenyl Cyclopentylmethanone Results treatment saline I significance different experiment Conclusion anti depressant However week short 6SHNK SHNK 2S6S SS

ABSTRACT Objectives: The aims of the present study were to compare the long-term outcomes for ascending aortic dilatation and adverse aortic events after isolated aortic valve replacement between patients with bicuspid aortic valve (BAV) and tricuspid aortic valve ( TAV). Methods: This retrospective study included 310 patients who had undergone isolated aortic valve replacement with an ascending aorta diameter ≤ 45 mm between January 2010 and September 2021. The patients were divided into BAV group (n=90) and TAV group (n=220). The differences in the dilation rate of the ascending aorta and long-term outcomes were analyzed. Results: Overall survival was 89 ± 4% in the BAV group vs. 75 ± 6% in the TAV group at 10 years postoperatively (P=0.007), yet this difference disappeared after adjusting exclusively for age (P=0.343). The mean annual growth rate of the ascending aorta was similar between the two groups during follow-up (0.5 ± 0.6 mm/year vs. 0.4 ± 0.5 mm/year; P=0.498). Ten-year freedom from adverse aortic events was 98.1% in the BAV group vs. 95.0% in the TAV group (P=0.636). Multivariable analysis revealed preoperative ascending aorta diameter to be a significant predictor of adverse aortic events (hazard ratio: 1.76; 95% confidence interval: 1.33 to 2.38; P<0.001). Conclusion: Our study revealed that the long-term survival and the risks of adverse aortic events between BAV and TAV patients were similar after isolated aortic valve replacement. BAV was not a risk factor of adverse aortic events. Objectives longterm long term (BAV TAV. . TAV) Methods 31 4 201 2021 n=90 n90 n 90 (n=90 n=220. n220 n=220 220 (n=220) analyzed Results 8 vs 7 6 1 P=0.007, P0007 P P=0.007 , 0 007 (P=0.007) P=0.343. P0343 P=0.343 343 (P=0.343) followup follow up 05 5 (0. 06 0. mmyear year 04 P=0.498. P0498 P=0.498 498 P=0.498) Tenyear Ten 981 98 98.1 950 95 95.0 P=0.636. P0636 P=0.636 636 (P=0.636) hazard ratio 1.76 176 76 interval 133 33 1.3 2.38 238 2 38 P<0.001. P0001 P<0.001 001 P<0.001) Conclusion 3 20 202 n=9 n9 9 (n=9 n22 n=22 22 (n=220 P000 P=0.00 00 (P=0.007 P034 P=0.34 34 (P=0.343 (0 P049 P=0.49 49 98. 95. P063 P=0.63 63 (P=0.636 1.7 17 13 1. 2.3 23 P<0.00 n= (n= n2 n=2 (n=22 P00 P=0.0 (P=0.00 P03 P=0.3 (P=0.34 P04 P=0.4 P06 P=0.6 (P=0.63 2. P<0.0 (n (n=2 P0 P=0. (P=0.0 (P=0.3 (P=0.6 P<0. P=0 (P=0. P<0 P= (P=0 P< (P= (P

Resumo: Este estudo emprega metodologia de teoria fundamentada, utilizando técnicas de codificação aberta, codificação axial e codificação seletiva, para conduzir uma análise sistemática da “Coleção de Padrões Decorativos Chineses”, de Pang Xunqin. Uma estrutura teórica é construída para explorar a fusão de padrões tradicionais chineses com o design de arte decorativa moderna. Como pioneira nesse domínio, a obra de Pang Xunqin não apenas preenche lacunas históricas nas artes decorativas chinesas, mas também oferece insights inovadores para a progressão da arte e do design chineses contemporâneos. A análise de codificação do estudo revela a integração hábil de padrões tradicionais em práticas de design modernas, por Pang Xunqin, aprimorando, assim, a identidade cultural e o vigor artístico. Além disso, um modelo dinâmico é introduzido, traçando caminhos inovadores para a evolução moderna de padrões tradicionais e promovendo sua disseminação cultural global e inovação. Esse modelo enriquece nossa compreensão da fusão de tradição e modernidade e apresenta uma nova perspectiva para a observação e a aplicação da cultura tradicional em cenários contemporâneos. Resumo fundamentada aberta seletiva Coleção Chineses, Chineses , Chineses” domínio chinesas contemporâneos modernas aprimorando assim artístico disso introduzido inovação

Abstract: This study employs grounded theory methodology, utilizing open coding, axial coding, and selective coding techniques, to conduct a systematic analysis of Pang Xunqin’s “Chinese Decorative Pattern Collection.” A theoretical framework is constructed to explore the fusion of traditional Chinese patterns with modern decorative art design. As a pioneer in this domain, Pang Xunqin’s oeuvre not only bridges historical gaps in Chinese decorative arts, but also offers innovative insights for the progression of contemporary Chinese art and design. The coding analysis of the study reveals the adept integration of traditional patterns into modern design practices by Pang Xunqin, thereby enhancing cultural identity and artistic vigor. Additionally, a dynamic model is introduced, charting innovative pathways for the modern evolution of traditional patterns and fostering their global cultural dissemination and innovation. This model enriches our comprehension of the amalgamation of tradition and modernity and presents a novel perspective for the observation and application of traditional culture in contemporary settings. Abstract methodology techniques Xunqins Xunqin s Collection. Collection domain arts vigor Additionally introduced innovation settings

Abstract Aim Primary Signet Ring Cell Carcinoma (SRCC) of the bladder accounts for only 1%‒4% of all bladder malignancies. To date, few studies have been conducted to investigate the characteristics of SRCC. This study aimed to investigate the clinical features and treatments of SRCC and explore the independent risk factors of survival in SRCC patients. Patients and methods A retrospective study was conducted on 32 eligible patients. The survival rate was calculated with the Kaplan-Meier method, and the COX proportional hazards model was used to investigate the independent risk factors of prognosis. Results In the present study, the 1-year and 2-year survival rates of SRCC patients were 53.1% and 9.4%, respectively. The TNM stage, tumor differentiation, and metastasis after treatment were risk factors for the prognosis of SRCC patients (p < 0.05), while surgical treatment, chemotherapy, and positive GATA3 expression were protective for prognosis (p < 0.05). Multivariate analysis showed that GATA3 was an independent protective factor for prognosis (p < 0.05), and T-stage was an independent risk factor (p < 0.05). Conclusions Primary SRCC of the bladder is highly malignant and has a poor prognosis. Its clinical and imaging findings are usually non-specific. Early radical cystectomy and postoperative adjuvant systemic chemotherapy are helpful to improve the survival rate. T-stage is an independent risk factor for survival, and positive GATA3 expression is protective for primary SRCC of the bladder. (SRCC 14 1 4 1%‒4 malignancies date 3 KaplanMeier Kaplan Meier method 1year year 2year 2 531 53 53.1 94 9 9.4% respectively stage differentiation p 0.05, 005 0.05 , 0 05 0.05) GATA 0.05. . Tstage T nonspecific. nonspecific non specific. specific non-specific 1%‒ 5 53. 9.4 00 0.0 1% 9. 0.

Abstract Objective: To investigate the clinical implications of Golgi glycoprotein 73 (GP73) and granulocyte colony-stimulating factor (G-CSF) in children with bronchopneumonia (BP). Methods: Seventy-two children with BP (observation group) and 81 healthy children (control group) consecutively brought to the present study's hospital between June 2019 and October 2020 were enrolled. GP73 and G-CSF levels were determined to analyze their diagnostic value for pediatric BP. High-sensitivity C-reactive protein (hs-CRP) was also measured. The clinical implications of GP73 and G-CSF in pediatric BP complicated with respiratory failure and their connections with the inflammatory response were discussed. Results: GP73 and G-CSF levels were remarkably higher in the observation group (p< 0.05). The sensitivity and specificity of combined detection (GP73+G-CSF) in predicting pediatric BP were 72.22% and 86.42%, respectively (p < 0.001 ). GP73 and G-CSF, which are closely related to X-ray classification and complications in the observation group, decreased after treatment and were positively correlated with hs-CRP (p < 0.05), especially in children complicated with respiratory failure. Regression analysis identified the independence of the course of the disease, hs-CRP, X-ray classification, GP73, and G-CSF as influencing factors of respiratory failure in children with BP (p < 0.05). Conclusion: GP73 and G-CSF, with elevated levels in children with BP, are strongly linked to disease progression and are independent influencing factors of respiratory failure, which may be the key to diagnosing and treating pediatric BP in the future. Objective 7 GP (GP73 colonystimulating colony stimulating GCSF G CSF (G-CSF . (BP) Methods Seventytwo Seventy two 8 control studys study s 201 202 enrolled GP7 Highsensitivity High Creactive C reactive hsCRP hs CRP (hs-CRP measured discussed Results p< p 0.05. 005 0.05 0 05 0.05) GP73+GCSF GP73GCSF GPGCSF GP73+G (GP73+G-CSF 7222 72 22 72.22 8642 86 42 86.42% 0001 001 0.00 ) GCSF, CSF, Xray X ray 0.05, , hsCRP, CRP, Conclusion future (GP7 (BP 20 00 0.0 GP73G GPG 722 2 72.2 864 4 86.42 000 (GP 0. 72. 86.4 86.

RESUMEN Introducción: El entrenamiento especial temprano se ha utilizado ampliamente con el objetivo de mejorar el rendimiento deportivo en los jóvenes atletas de boxeo chinos. Para que los deportistas aprovechen mejor su tiempo de entrenamiento y acumulen el máximo de habilidades competitivas especiales, es necesario un entrenamiento intensivo desde su juventud. Objetivo: Estudiar la capacidad competitiva de los atletas chinos de boxeo bajo fortalecimiento a través del entrenamiento físico temprano. Métodos: Mediante el método bibliográfico, los métodos experimentales y el análisis estadístico matemático, se analizó la composición corporal de los atletas y su rendimiento en actividades físicas específicas y funcionales. Resultados: Hubo diferencias significativas en el IMC, la altura y la longitud de las extremidades entre los jóvenes atletas (P<0,05). No hubo diferencias significativas en la altura, la distancia entre los dedos y la longitud del tendón de Aquiles (P>0,05). No se encontraron diferencias significativas en la flexibilidad y la sensibilidad entre los voluntarios (P>0,05). Conclusión: Los atletas que participan en el entrenamiento temprano están uniformemente emparejados, el nivel de habilidad táctica de los atletas en entrenamiento tiene un diferencial que puede impactar directamente en el futuro rendimiento deportivo, siendo recomendada esta práctica para mejorar el rendimiento deportivo de los atletas. Nivel de evidencia II; Estudios terapéuticos - investigación de los resultados del tratamiento. Introducción especiales juventud Objetivo Métodos bibliográfico matemático funcionales Resultados IMC P<0,05. P005 P P<0,05 . 0 05 (P<0,05) P>0,05. P>0,05 (P>0,05) Conclusión emparejados II tratamiento P00 P<0,0 (P<0,05 P>0,0 (P>0,05 P0 P<0, (P<0,0 P>0, (P>0,0 P<0 (P<0, P>0 (P>0, P< (P<0 P> (P>0 (P< (P> (P

RESUMO Introdução: O treinamento especial precoce tem sido amplamente utilizado visando melhorar o desempenho atlético em jovens atletas de boxe chinês. No intuito dos atletas aproveitarem melhor o tempo de treino e acumular o máximo de habilidades competitivas especiais, é requerido um treinamento intensivo desde sua juventude. Objetivo: Estudar a capacidade competitiva dos atletas de boxe chinês sob o fortalecimento através do treinamento físico precoce. Métodos: Através do método de literatura, métodos experimentais e análise estatística matemática, analisou-se a composição corporal dos atletas, seu desempenho em atividades físicas específicas e funcionais. Resultados: Houve diferenças significativas no IMC, altura e comprimento de membros entre os jovens atletas (P<0,05). Não houve diferença significativa na altura, distância entre os dedos, comprimento do tendão de Aquiles (P>0,05). Não foi encontrada diferença significativa na flexibilidade e na sensibilidade entre os voluntários (P>0,05). Conclusão: Os atletas participantes do treinamento precoce são uniformemente equiparados, o nível de habilidade tática dos atletas sob capacitação nesse treinamento tem um diferencial que pode impactar diretamente sobre o desempenho esportivo futuro, sendo recomendada essa prática para melhorar o desempenho esportivo dos atletas. Nível de evidência II; Estudos terapêuticos - investigação dos resultados do tratamento. Introdução especiais juventude Objetivo Métodos literatura matemática analisouse analisou se funcionais Resultados IMC P<0,05. P005 P P<0,05 . 0 05 (P<0,05) dedos P>0,05. P>0,05 (P>0,05) Conclusão equiparados futuro II tratamento P00 P<0,0 (P<0,05 P>0,0 (P>0,05 P0 P<0, (P<0,0 P>0, (P>0,0 P<0 (P<0, P>0 (P>0, P< (P<0 P> (P>0 (P< (P> (P

ABSTRACT Introduction: Early special training has been widely used to improve athletic performance in young Chinese boxing athletes. For athletes to make better use of training time and accumulate maximum special competitive skills, intensive training is required from their youth. Objective: Study the competitive ability of Chinese boxing athletes under strengthening through early physical training. Methods: Through literature method, experimental methods, and mathematical statistical analysis, the athletes’ body composition and their performance in specific and functional physical activities were analyzed. results: Young athletes significantly differed in BMI, height, and limb length (P<0.05). There was no significant difference in height, the distance between fingers, Achilles tendon length (P>0.05). No significant difference was found in flexibility and sensitivity among volunteers (P>0.05). Conclusion: The athletes participating in early training are uniformly matched, the level of tactical ability of the athletes under training has a differential that can directly impact future sports performance, and this practice is recommended to improve the athletes’ sports performance. Level of evidence II; Therapeutic studies - investigation of treatment outcomes. Introduction skills youth Objective Methods method methods analysis analyzed results BMI height P<0.05. P005 P P<0.05 . 0 05 (P<0.05) fingers P>0.05. P>0.05 (P>0.05) Conclusion matched II outcomes P00 P<0.0 (P<0.05 P>0.0 (P>0.05 P0 P<0. (P<0.0 P>0. (P>0.0 P<0 (P<0. P>0 (P>0. P< (P<0 P> (P>0 (P< (P> (P

Abstract The conversion of sesamin to asarinin is a promising route for the production of asarinin. This work reports the affection of acid type and strength of the catalyst on the conversion of sesamin to asarinin and the effect of various reaction conditions in anhydrous ethanol using phosphotungstic acid (HPW) as catalyst. The experimental results indicate that the activity of sesamin conversion is determined by strong B acids. L acids are not active for the reaction, and do not show synergy with B acids for the formation of asarinin. Reaction time, HPW dosage and temperature have significant effects on sesamin conversion. A maximum asarinin yield of 57.93% was achieved. The reaction kinetics in the temperature range 55-75 °C were studied. The kinetic curves can be successfully fitted with an opposing first-order reaction model. The activation energy (Ea) for this reaction is found to be 105.2 ± 0.4 kJ/mol. (HPW time 5793 57 93 57.93 achieved 5575 55 75 55-7 C studied firstorder first order model Ea (Ea 1052 105 2 105. 04 0 4 0. kJmol kJ mol kJ/mol 579 5 9 57.9 557 7 55- 10 57. 1

ABSTRACT To provide an efficient and reliable calibration method with reduced time cost and increased accuracy, the angle of repose (AoR) in the simulation is batch-processed based on Python and the GA-BP neural network is used to improve the prediction accuracy of the DEM parameters of coated fertilizer particles. The single-factor test data were firstly interpolated to obtain sufficient training samples, thus avoiding the drawback that the BP network tends to fall into the local minimum during the training process. Then the GA-BP neural network was trained in combination with the orthogonal combination test, and the fitted correlation coefficients were all greater than 0.975, indicating that the algorithm has strong generalization performance and good stability. The predicted values matched the expected output values, indicating that the GA-BP neural network can accurately predict the nonlinear function output, and the network predicted output can be approximated as the actual output of the function. With the actual AoR as the output value, the simulation value of the AoR was obtained as 24.457° when the coefficient of restitution (CoR), coefficient of static friction (CoSF), and coefficient of rolling friction (CoRF) were 0.509, 0.176, and 0.0332, respectively, and the relative error with the actual value was 0.068%, indicating that the well-fitted GA-BP neural network could accurately predict the DEM parameters of fertilizer particles. (AoR batchprocessed batch processed GABP GA particles singlefactor single factor samples process 0975 0 975 0.975 stability 24457 24 457 24.457 CoR, CoR , (CoR) CoSF, CoSF (CoSF) CoRF (CoRF 0509 509 0.509 0176 176 0.176 00332 0332 0.0332 respectively 0068 068 0.068% wellfitted well 097 97 0.97 2445 2 45 24.45 (CoR (CoSF 050 50 0.50 017 17 0.17 0033 033 0.033 006 06 0.068 09 9 0.9 244 4 24.4 05 5 0.5 01 1 0.1 003 03 0.03 00 0.06 0. 24. 0.0

Resumo Para avaliar quantitativamente o efeito da altura do restolho e da cobertura morta na resistência do solo à erosão do vento em terras cultivadas protegidas de castanheiros sob diferentes condições de velocidade do vento, foram realizados testes de conservação e lavoura convencional no planalto da Mongólia, China, utilizando um túnel móvel de vento de erosão do vento. Os solos de castanha são um tipo de solo em ecossistemas semi-áridos frágeis que são suscetíveis à desertificação após a erosão pelo vento e são encontrados principalmente na Ásia Central e no continente norte-americano. Os resultados mostram que a erosão do solo na lavoura de conservação é menor do que a lavoura convencional em diferentes velocidades de vento. A resistência da lavoura de conservação à erosão do solo pelo vento aumenta com o aumento da altura do restolho e da cobertura. Com uma altura do restolho de 300 mm e uma cobertura de 50%, a eficiência média de resistência da lavoura de conservação à erosão pelo vento é de 74,82%, evitando efetivamente a erosão pelo vento dos solos agrícolas. Mongólia China semiáridos semi áridos norteamericano. norteamericano norte americano. americano norte-americano 30 50 50% 7482 74 82 74,82% agrícolas 3 5 748 7 8 74,82 74,8 74,

ABSTRACT >To quantitatively evaluate the effect of stubble height and mulching on soil resistance to wind erosion in protected cultivated chestnut soil farmland under different wind speed conditions, tests were carried out on conservation and conventional tillage in Mongolian Plateau, China, using a mobile wind erosion wind tunnel. Chestnut soils were a soil type in fragile semi-arid ecosystems that were susceptible to desertification following wind erosion and were found mainly in Central Asia and the North American continent. The results show that soil erosion on conservation tillage was lower than conventional tillage at different wind speeds. The resistance of conservation tillage to soil wind erosion increases with increasing stubble height and cover. At a stubble height of 300 mm and 50% cover, conservation tillage's average wind erosion resistance efficiency was 74.82%, effectively preventing wind erosion of agricultural soils. To conditions Plateau China tunnel semiarid semi arid continent speeds cover 30 50 tillages s 7482 74 82 74.82% 3 5 748 7 8 74.82 74.8 74.