Abstract Background In recent years, cyclooxygenase-2 (COX-2) has been identified as a cancer stem cell (CSC) marker in gliomas. Nevertheless, the clinical and prognostic significance of COX-2 in glioma patients remains controversial. Objective To evaluate the correlation of COX-2 with the prognosis in glioma patients. Methods Eligible studies on this subject were included, and pooled odd ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (95%CIs) were estimated. Publication bias was assessed through funnel plots, and heterogeneity and sensitivity were analyzed as well. Results In the present study, 11 articles with a total of 641 patients were included. The high expression of COX-2 in glioma patients was negatively associated with overall survival (OS) (n = 11; HR = 2.26; 95%CI = 1.79–2.86), and the subgroup analysis showed no differences in OS between Asian (n = 5; HR = 2.16; 95%CI = 1.57–2.97) and non-Asian (n = 6; HR = 2.39; 95%CI = 1.69–3.38) glioma patients. The Begg funnel plots test indicated that there was no evident risk of publication bias in the meta-analysis. Conclusion The present study suggests that COX-2 could be recommended as a useful pathological and prognostic biomarker in the clinical practice. years cyclooxygenase2 cyclooxygenase 2 cyclooxygenase- COX2 COX (COX-2 CSC (CSC gliomas Nevertheless COX- controversial included ORs (ORs HRs (HRs 95 95%CIs 95CIs CIs (95%CIs estimated well 1 64 (OS n 2.26 226 26 95CI CI 1.79–2.86, 179286 1.79–2.86 , 79 86 1.79–2.86) 5 2.16 216 16 1.57–2.97 157297 57 97 nonAsian non 6 2.39 239 39 1.69–3.38 169338 69 3 38 metaanalysis. metaanalysis meta analysis. meta-analysis practice (COX- 9 2.2 22 17928 1.79–2.8 7 8 2.1 21 1.57–2.9 15729 2.3 23 1.69–3.3 16933 (COX 2. 1792 1.79–2. 1.57–2. 1572 1.69–3. 1693 179 1.79–2 1.57–2 157 1.69–3 169 17 1.79– 1.57– 15 1.69– 1.79 1.57 1.69 1.7 1.5 1.6 1.

Resumo Introdução Nos últimos anos, a ciclooxigenase-2 (COX-2) foi identificada como um marcador de células-tronco cancerígenas (CSC) em gliomas. No entanto, o significado clínico e prognóstico da COX-2 em pacientes com glioma permanece controverso. Objetivo Avaliar a correlação da COX-2 com o prognóstico em pacientes com glioma. Métodos Estudos elegíveis sobre este assunto foram incluídos e foram estimadosodds ratios (ORs) ehazard ratios (HRs) com intervalos de confiança de 95% (IC 95%). O viés de publicação foi avaliado por meio de gráficos de funil, e a heterogeneidade e a sensibilidade também foram analisadas. Resultados No presente estudo foram incluídos 11 artigos com um total de 641 pacientes. A alta expressão de COX-2 em pacientes com glioma foi negativamente associada à sobrevida global (OS) (n = 11; HR = 2,26; IC 95% = 1,79-2,86), e a análise de subgrupo não mostrou diferenças na OS entre asiáticos (n = 5; HR = 2,16; IC 95% = 1,57–2,97) e não asiáticos (n = 6; HR = 2,39; IC 95% = 1,69–3,38) pacientes com glioma. O teste de gráficos de funil de Begg indicou que não havia risco evidente de viés de publicação na metanálise. Conclusão O presente estudo sugere que a COX-2 pode ser recomendada como um biomarcador patológico e prognóstico útil na prática clínica. anos ciclooxigenase2 ciclooxigenase 2 ciclooxigenase- COX2 COX (COX-2 célulastronco células tronco CSC (CSC gliomas entanto COX- controverso ORs (ORs HRs (HRs 95 95%. . 95%) analisadas 1 64 (OS n 2,26 226 26 1,792,86, 179286 1,79 2,86 , 79 86 1,79-2,86) 5 2,16 216 16 1,57–2,97 157297 57 97 6 2,39 239 39 1,69–3,38 169338 69 3 38 metanálise clínica (COX- 9 2,2 22 792 1,792,86 17928 179 1,7 286 2,8 7 8 1,79-2,86 2,1 21 1,57–2,9 15729 2,3 23 1,69–3,3 16933 (COX 2, 1,792,8 1792 17 1, 28 1,79-2,8 1,57–2, 1572 1,69–3, 1693 1,792, 1,79-2, 1,57–2 157 1,69–3 169 1,792 1,79-2 1,57– 15 1,69– 1,79- 1,57 1,69 1,5 1,6

Precipitation interpolation is widely used to generate continuous rainfall surfaces for hydrological simulations. However, increasing the precision of values at the unknown points generated by different spatial interpolation methods is challenging. This study used the Chaohe River Basin, which is an important source of Beijing's drinking water, as a research area to comprehensively evaluate several precipitation interpolation methods (Thiessen polygon, inverse distance weighting, ordinary kriging and ANUSPLIN) for inputs in hydrological simulations. This research showed that the precipitation time-series surface generated using the ANUSPLIN interpolation method had higher accuracy and reliability. Using this precipitation input to drive the hydrological models, we explored the parameter uncertainties of four typical hydrological models (GR4J, IHACRES, Sacramento and MIKE SHE) based on the multi-objective generalized likelihood uncertainty estimation (GLUE) method. The GLUE method was used to study the parameter sensitivity and uncertainty of the model. Results showed that the ANUSPLIN precipitation interpolation surface combined with the Sacramento model performed best. The multi-objective GLUE method had obvious advantages in parameter uncertainty analysis in hydrological models. Simultaneously exploring the convex line and point density distributions of the behavioural parameters with multi-objective functions determined their distribution and sensitivity more effectively.

Abstract Fundamental motor skills (FMS) are the foundation for the development of advanced motor skills. To assess the effect of physical activity intervention on the promotion of FMS and explore the influencing factor of physical activity intervention on the development of FMS in preschool children. Trails with children aged 3-7yeas in kindergarten settings that applied physical activity intervention programs were included. We calculated the effects on overall FMS, locomotor skill and object control skill subscales (LMS and OCS) by weighted standardized mean differences using random-effects models. In this study, 23 trials involving 2258 preschoolers (aged 3.3-6.5years) were selected, including 7 high quality studies, 11 medium quality studies and 5 low quality studies. Analysis of the effects of physical activity intervention revealed significant differences among groups in favor of intervention group, FMS (SMD = 1.50, 95% CL [1.29, 1.71], I2 = 89.7%), locomotor skills (SMD = 1.56, 95% CL [1.38, 1.75], I2 = 59.2%), object control skills (SMD = 1.43, 95% CL [1.25, 1.61], I2 = 93.8%). Physical activity interventions can significantly improve FMS in healthy preschool aged children. However, we should be cautious due to the limited researches, low-quality evidence and immediate post-intervention effects without long-term follow-up.

Abstract A novel two-step process of Cr-Mn pack cementation and thermal oxidation was applied to fabricate a MnCr2O4 spinel coating on HP 40 alloy. The Cr-Mn diffusion layer formed after the Cr-Mn pack cementation process is lacking in Fe and Ni. A dense and uniform coating formed on the alloy following thermal oxidation. The coating is mainly composed of MnCr2O4 spinel phase, while the outer surface of the coating is completely MnCr2O4 spinel. The coating exhibits a favorable thickness of about 7 µm according to SEM and EDS maps of its cross-section. The MnCr2O4 spinel coating significantly affects the coking mechanism and coke property according to coking experiments. Raman spectroscopy shows that the coated sample inhibits catalytic coke formation as more disordered carbon and amorphous carbon layers are present. Moreover, the coating is stable in coking and decoking environments.

Systematic investigation was made on the magnetic property of a series of Nd2Fe14B/α-Fe nanocomposites prepared by crystallization of amorphous Nd8Fe84Ti2B6 ribbon at annealing temperatures in the range of 800-860 °C. Both remanence and energy product increase with increasing annealing temperature, reaching the maximum values at 850 °C. Coercivity remains around 5.5 kOe for the annealing temperatures above 800 °C. Although the smooth demagnetization curve indicates effective exchange coupling between the Nd2Fe14B/α-Fe dual phases, FORC diagram reveals the existence of α-Fe for the Nd8Fe84Ti2B6 ribbon annealed at 850 °C. In addition, the variation of microcoercivity at different locations indicates a distributed exchange interaction, which can be caused by the nonuniform microstructure. The magnetic property is also affected by the demagnetization effect caused by the particle shape, which is evidenced by the negative region in the first-order reversal curve (FORC) diagram.