Abstract Objective: This study aimed to investigate non-alcoholic fatty liver disease (NAFLD) occurrence and factors associated with the disease in phenylketonuria (PKU) patients undergoing exclusive dietary treatment. Method: This cross-sectional study included 101 adolescents 10 to < 20 years of age with PKU, who were undergoing exclusive dietary treatment and monitored since early diagnosis at a single reference service. Anthropometric and biochemical assessments were performed and food intake was documented, and an ultrasound diagnosis of NAFLD was established. Data were evaluated using the Student’s t-test for continuous variables, the chi-square for categorical variables, and logistic regression using the Wald chi-squared test; differences with p < 0.05 were considered to be statistically significant. Results: NAFLD was detected in 26 (25.7%) teenagers. There was no difference in prevalence between the sexes or nutritional status. The final logistic regression model revealed low sensitivity (26.1%) and high specificity (94.7%). The specificity suggested a lower likelihood of NAFLD in older adolescents, in the presence of normal or high levels of alkaline phosphatase, lower carbohydrate intake, and adequate protein and lipid intake. Conclusions: The prevalence of NAFLD in adolescents with PKU was higher than that found in healthy Brazilian adolescents and similar to that found in obese Brazilian children, suggesting a higher risk for NAFLD in patients with PKU treated exclusively by dietary modification. Objective nonalcoholic non alcoholic (NAFLD (PKU Method crosssectional cross sectional 1 2 service documented established Students Student s ttest t test variables chisquare chi square chisquared squared 005 0 05 0.0 significant Results 25.7% 257 25 7 (25.7% teenagers status 26.1% 261 (26.1% 94.7%. 947 94.7% . 94 (94.7%) phosphatase Conclusions children modification 00 0. 25.7 (25.7 26.1 (26.1 94.7 9 (94.7% 25. (25. 26. (26. 94. (94.7 (25 (26 (94. (2 (94 ( (9

Abstract Objective: To estimate the prevalence and factors associated with overweight/obesity development in adolescents with early diagnosed phenylketonuria treated exclusively by diet. Methodology: In this cross-sectional study anthropometric measurements, serum phenylalanine levels, and 10 metabolites associated with lipid and carbohydrate metabolism were analyzed in 101 adolescents aged 10–20 years. Adolescents were categorized into overweight/obesity and eutrophic/low body mass index groups. These patients were compared using Student’s t-test, Pearson’s chi-square test, Wald’s chi-square test for multivariate analysis. Further, to verify whether the prevalence of overweight/obesity found in the study population was similar to that in the general population, the authors compared the nutritional status of 46 patients aged 13–17 years with that of healthy students of the same age from the National School Health Survey using the chi-square test for adherence. The significance threshold was p < 0.5. Results: The prevalence of overweight/obesity in adolescents was 27.7%. There was no difference in prevalence between sexes. Older age was a protective factor and Increased Homeostasis Model Assessment Insulin Resistance index and high phenylalanine and low-density lipoprotein cholesterol levels were predictive factors for overweight/obesity. The equality hypothesis was not rejected in the comparison of nutritional states of 46 patients aged 13–17 years and healthy students of the same age. Conclusion: The prevalence of overweight/obesity in phenylketonuria adolescents was similar to what is found in healthy adolescents.

OBJETIVO: apresentar o percurso seguido pela Fonoaudiologia no estado de Minas Gerais desde a chegada dos primeiros profissionais até os dias de hoje. MÉTODO: trata-se de pesquisa de campo, exploratória e histórica, de abordagem qualiquantitativa. Participaram 27 profissionais, fonoaudiólogos e médicos envolvidos no processo de implantação, organização e gestão de serviços, cursos e consultórios de Fonoaudiologia. A coleta de dados ocorreu por meio do levantamento de documentos e entrevistas semi-estruturadas. Após essa fase, houve a categorização dos documentos e das entrevistas. RESULTADOS: o relato do histórico se inicia com a chegada dos primeiros fonoaudiólogos em Minas Gerais. A descrição das entrevistas se divide nas seguintes categorias: contato com a Fonoaudiologia; motivação para a escolha da profissão; inserção na Fonoaudiologia; motivação para o trabalho em Minas; contexto da Fonoaudiologia em Minas Gerais nas décadas de 70 a 90; formação profissional; impulsos para o reconhecimento e avanços da profissão; perspectivas da Fonoaudiologia; avaliação do estudo histórico. CONCLUSÃO: foi possível demonstrar o caminho que a Fonoaudiologia traçou no estado de Minas Gerais desde a chegada dos primeiros fonoaudiólogos até os dias de hoje.

PURPOSE: to present the course traced by Speech-language Pathology in Minas Gerais state since the arrival of the first professionals up to the current time. METHOD: it is an exploratory and historical field research based on a quality-quantitative approach. Twenty-seven professionals including speech-language pathologists and doctors involved in the process of implementing, organizing and managing services, courses and Speech-language pathology offices took part in this study. Data were collected by using documents research and semi-structured interviews. Then, there was a categorization of the documents and interviews. RESULTS: the historical report begins with the arrival of the first speech-language pathologists in Minas Gerais. The description of the interviews is divided in the following categories: first time in touch with Speech-language pathology; motivation for choosing this professional occupation; insertion in Speech-language pathology; motivation for working in Minas Gerais; context of this science from the 1970s to the 1990s; career development; boost to the recognition and progress of the profession; Speech-language pathology perspectives; evaluation of the historical study. CONCLUSION: it was possible to demonstrate the course traced by Speech-language Pathology in Minas Gerais province since the arrival of the first professionals up to the current time.