Pesquisa | SciELO

Lantana caatingensis Moldenke (Verbenaceae) is an endemic plant from northeastern Brazil. However, its chemical composition is almost unknown. This study aimed to characterize the chemical compounds found in L. caatingensis and investigate the antileishmanial potential of its hydroalcoholic extract and polar fractions. Compounds present in the hydroalcoholic extract obtained from L. caatingensis leaves and its polar fractions (ethyl acetate and methanolic) were analyzed by liquid chromatography with a photodiode-array detector coupled to electrospray ionization quadrupole time-of-flight mass spectrometry. An antileishmanial assay was performed in a 96-well plate against Leishmania major promastigotes using resazurin on a plate spectrophotometer and the results were expressed as percentage of growth inhibition. Nine compounds were determined in the investigated extract and fractions, classified as flavonoids, flavonoid C-glycosides and phenylethanoid glycosides. The antileishmanial activity revealed that the hydroalcoholic extract and the ethyl acetate fraction were active against L. major promastigotes with inhibitory concentration of 71.78 and 26.86 µg mL-1, respectively, while the methanolic fraction was inactive (478.40 µg mL-1). This is the first report on the chemical composition and antileishmanial activity of L. caatingensis extracts. These results contribute to further knowledge of species belonging to the Lantana genus. Verbenaceae (Verbenaceae Brazil However unknown L photodiodearray photodiode array timeofflight time flight spectrometry 96well well 96 inhibition flavonoids Cglycosides C glycosides 7178 71 78 71.7 2686 26 86 26.8 mL1, mL1 mL 1, 1 mL-1 respectively 478.40 47840 478 40 (478.4 mL1. . mL-1) extracts genus 9 717 7 71. 268 2 8 26. mL- 478.4 4784 47 4 (478. 478. (478 (47 (4 (

https://doi.org/10.21577/0103-5053.20240113

[SciELO Preprints] - Vertical Transmission of Oropouche Virus in a Newly Affected Extra-Amazon Region: A Case Study of Fetal Infection and Death in Ceará, Brazil
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Garcia Filho, Carlos Lima Neto, Antônio Silva Maia, Ana Maria Peixoto Cabral Silva, Luiz Osvaldo Rodrigues Cavalcante, Robson da Costa Monteiro, Higor da Silva Marques , Kamilla Carneiro Alves Oliveira, Rebeca de Souza Gadelha, Sami de Andrade Cordeiro Melo, Deborah Nunes de Mota, Anacelia Gomes de Matos Lima, Shirlene Telmos Silva de Cavalcante, Karene Ferreira Duarte, Larissa Maria Façanha Cavalcante, Ítalo José Mesquita Mello, Leda Maria Simões Alencar, Carlos Henrique Freitas, Andre Ricardo Ribas Cavalcanti, Luciano Pamplona de Góes

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Data de publicação: 2024-08-27

Resumo: Pt En Es

A transmissão do vírus Oropouche (OROV) para novas regiões, juntamente com um aumento de casos e o surgimento de formas graves, anteriormente não suspeitas, expressas preocupações de saúde pública. Uma fazendeira grávida de 40 anos, com 30 semanas de gestação, desenvolvimento de febre, mialgia e dor de cabeça, com infecção por OROV confirmada por RT-qPCR. as avaliações maternas e fetais não foram inicialmente concluídas. No entanto, na semana seguinte, um paciente notou diminuição dos movimentos fetais, e o ultrassom confirmou a morte fetal. O diagnóstico molecular detectou o RNA do OROV em vários espécimes fetais. Este caso de transmissão vertical ressalta a necessidade urgente de proteger as mulheres grávidas, incorporar o OROV no diagnóstico diferencial de doenças febris e investigar mais profundamente os potenciais mecanismos patogênicos do vírus.

A transmissão do vírus Oropouche (OROV) para novas regiões, juntamente com um aumento de casos e o surgimento de formas graves, anteriormente não suspeitas, expressas preocupações de saúde pública. Uma fazendeira grávida de 40 anos, com 30 semanas de gestação, desenvolvimento de febre, mialgia e dor de cabeça, com infecção por OROV confirmada por RT-qPCR. as avaliações maternas e fetais não foram inicialmente concluídas. No entanto, na semana seguinte, um paciente notou diminuição dos movimentos fetais, e o ultrassom confirmou a morte fetal. O diagnóstico molecular detectou RNA do OROV em vários espécimes fetais. Este caso de transmissão vertical ressalta a necessidade urgente de proteger as mulheres grávidas, incorporar o OROV no diagnóstico diferencial de doenças febris e investigar mais profundamente os potenciais mecanismos patogênicos do vírus.

A propagação do vírus Oropouche (OROV) em novas regiões, junto com um aumento de casos e o aparecimento de formas graves não reconhecidas anteriormente, suscitou preocupações importantes de saúde pública. Uma granjera embarazada de 40 anos em 30 semanas de gestação apresentou febre, mialgia e dor de cabeça, e a infecção por OROV foi confirmada por RT-qPCR. As avaliações maternas e fetais não foram avaliadas inicialmente. No entanto, na semana seguinte, o paciente notou uma diminuição dos movimentos fetais e a ecografia confirmada a morte fetal. Os diagnósticos moleculares detectam ARN de OROV em múltiplas amostras fetais. Este caso de transmissão vertical justifica a necessidade urgente de proteger as mulheres embaraçadas, incorporar o OROV no diagnóstico diferencial de doenças febris e investigar mais o fundo dos possíveis mecanismos patogênicos do vírus.

https://doi.org/10.1590/SciELOPreprints.9667

Alert for the high prevalence of vitamin D deficiency in adolescents in a large Brazilian sample
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Radonsky, Vanessa

; Lazaretti-Castro, Marise

; Chiamolera, Maria Izabel

; Biscolla, Rosa Paula Mello

; Lima Junior, José Viana

; Vieira, José Gilberto Henriques

; Brandão, Cynthia Maria Alvares

; Ramalho, Rodrigo Fernandes

; Maeda, Sergio Setsuo

; Cavichio, Marcia Wehba Esteves

Jornal de Pediatria

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Ago 2024, Volume 100 Nº 4 Páginas 360 - 366

Resumo: En | Texto: En | PDF: En

Abstract Objective: To estimate the prevalence of vitamin D deficiency and severe deficiency in children and adolescents, in a large Brazilian sample. Methodology: Results of 413,988 25(OH)D measurements in children and adolescents aged 0 to 18 years collected between 01/2014 and 10/2018 were obtained from the database of a Clinical Laboratory. In this population, 25 hydroxyvitamin D concentrations below 20 ng/mL are considered deficient, and below 12 ng/mL as severe deficiency. All measurements were performed by immunoassay and the results were distributed by gender, age group, seasonality, and latitude. Results: The mean of 25(OH)D levels was 29.2 ng/mL with a standard deviation of 9.2 ng/mL. Of the total samples, 0.8% had a concentration < 12 ng/mL, and 12.5% of the samples had a concentration < 20 ng/mL, with a higher prevalence in females. Children under 2 years of age had the lowest prevalence. The effects of latitude and seasonality were quite evident. In samples of female adolescents from the southern region in winter, 36% of vitamin D deficiency and 5% of severe deficiency were found. Conclusion: In this large number of measurements of 25(OH)D in children and adolescents, 12.5% had a deficiency and 0.8% had severe deficiency. A greater deficiency was observed among adolescents, especially females, which raises questions about the need for supplementation during this period of life. Objective sample Methodology 413988 413 988 413,98 25OHD OHD OH 1 012014 01 2014 01/201 102018 10 2018 10/201 Laboratory population ngmL ng mL deficient gender group 292 29 29. 92 9 9. 08 8 0.8 125 5 12.5 females evident winter 36 found Conclusion life 41398 41 98 413,9 01201 201 01/20 10201 10/20 0. 12. 3 4139 4 413, 0120 01/2 1020 10/2 012 01/ 102 10/

https://doi.org/10.1016/jped.2024.01.003

High-fidelity simulation versus case-based discussion for training undergraduate medical students in pediatric emergencies: a quasi-experimental study Highfidelity High fidelity casebased case based emergencies quasiexperimental quasi experimental
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Moliterno, Nathalia Veiga

; Paravidino, Vitor Barreto

; Robaina, Jaqueline Rodrigues

; Lima-Setta, Fernanda

; Cunha, Antônio José Ledo Alves da

; Prata-Barbosa, Arnaldo

; Magalhães-Barbosa, Maria Clara de

Jornal de Pediatria

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Ago 2024, Volume 100 Nº 4 Páginas 422 - 429

Resumo: En | Texto: En | PDF: En

Abstract Objective: To evaluate the effect of high-fidelity simulation of pediatric emergencies compared to case-based discussion on the development of self-confidence, theoretical knowledge, clinical reasoning, communication, attitude, and leadership in undergraduate medical students. Methods: 33 medical students were allocated to two teaching methods: high-fidelity simulation (HFS, n = 18) or case-based discussion (CBD, n = 15). Self-confidence and knowledge tests were applied before and after the interventions and the effect of HFS on both outcomes was estimated with mixed-effect models. An Objective Structured Clinical Examination activity was conducted after the interventions, while two independent raters used specific simulation checklists to assess clinical reasoning, communication, attitude, and leadership. The effect of HFS on these outcomes was estimated with linear and logistic regressions. The effect size was estimated with the Hedge’sg. Results: Both groups had an increase in self-confidence (HFS 59.1 × 93.6, p < 0.001; CDB 50.5 × 88.2, p < 0.001) and knowledge scores over time (HFS 45.1 × 63.2, p = 0.001; CDB 43.5 × 56.7, p-value < 0.01), but no difference was observed between groups (group*time effect in the mixed effect models adjusted for the student ranking) for both tests (p = 0.6565 and p = 0.3331, respectively). The simulation checklist scores of the HFS group were higher than those of the CBD group, with large effect sizes in all domains (Hedges g 1.15 to 2.20). Conclusion: HFS performed better than CBD in developing clinical reasoning, communication, attitude, and leadership in undergraduate medical students in pediatric emergency care, but no significant difference was observed in self-confidence and theoretical knowledge. highfidelity high fidelity casebased case based selfconfidence, selfconfidence self confidence, confidence reasoning communication attitude Methods 3 methods HFS, 18 CBD, (CBD 15. 15 . 15) Selfconfidence Self mixedeffect regressions Hedgesg. Hedgesg Hedge sg. sg Hedge’sg Results 591 59 1 59. 936 93 6 93.6 0.001 0001 0 001 505 50 5 50. 882 88 2 88.2 451 45 45. 632 63 63.2 435 43 43. 567 56 7 56.7 pvalue value 0.01, 0.01 , 01 0.01) group*time grouptime ranking 06565 6565 0.656 03331 3331 0.3331 respectively. respectively respectively) Hedges 115 1.1 2.20. 220 2.20 20 2.20) Conclusion care 9 93. 0.00 000 00 8 88. 4 63. 56. 0.0 0656 656 0.65 0333 333 0.333 11 1. 22 2.2 0. 065 65 0.6 033 0.33 2. 06 03 0.3

https://doi.org/10.1016/j.jped.2024.03.007

Causalidade e Gravidade das Reações Adversas e Alterações Laboratoriais ao Tratamento com Benznidazol em Pacientes com Doença de Chagas Crônica
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Belmino, Alanna Carla da Costa

; Sousa, Emanuela Kelly Silva

; Silva Filho, José Damião da

; Rocha, Eduardo Arrais

; Nunes, Francisca Mylena Melgaço

; Sampaio, Tiago Lima

; Evangelista, Leones Fernandes

; Duque, Bruna Ribeiro

; Araújo, Isabel Cristina da Silva

; Jacó, José Igor de Oliveira

; Oliveira, Maria de Fátima

Arquivos Brasileiros de Cardiologia

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Ago 2024, Volume 121 Nº 8 elocation e20230787

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Fundamento A Doença de Chagas (DC) representa um grave problema de saúde pública na América Latina. O Benznidazol (BNZ) é utilizado para o tratamento DC e, apesar do seu amplo uso, poucas informações estão disponíveis sobre sua toxicidade e mecanismos das Reações Adversas ao Medicamento (RAM). Objetivos Identificar e classificar as reações adversas clínicas e laboratoriais ocasionadas pelo uso do BNZ quanto à sua causalidade e gravidade. Métodos Estudo de coorte prospectivo realizado no período de janeiro de 2018 a dezembro de 2021. O acompanhamento do tratamento incluiu consultas e análises laboratoriais antes, 30 e 60 dias após o início do tratamento. As RAM foram classificadas quanto à causalidade e gravidade. Na análise estatística o nível de significância adotado foi p<0,05. Resultados Participaram do estudo 40 pacientes com DC crônica, observou-se alta prevalência de RAM com um total de 161 em 30 (90%) pacientes. Destas, 104 (64,6%) foram classificadas como possíveis e 57 (35,4%) como prováveis. As reações foram classificadas em moderadas e leves. Dos 40 pacientes, nove (22,5%) suspenderam o tratamento. As RAM associadas à interrupção e intervenções foram as que afetaram o sistema dermatológico, sistema nervoso central e periférico ou que culminaram em ageusia. Após 30 dias de tratamento, alterações hematológicas e bioquímicas leves foram observadas como linfopenia. Conclusão Apesar do elevado percentual de RAM, muitos pacientes foram capazes de completar o tratamento, o que se atribui ao êxito da estratégia de acompanhamento com intervenções de tratamento sintomático juntamente ao aconselhamento, levando à compreensão da sintomatologia e manutenção do tratamento. (DC Latina (BNZ RAM. . (RAM) gravidade 201 2021 antes 3 6 p005 p 0 05 p<0,05 4 crônica observouse observou 16 90% 90 (90% Destas 10 64,6% 646 64 (64,6% 5 35,4% 354 35 (35,4% prováveis 22,5% 225 22 (22,5% dermatológico ageusia linfopenia aconselhamento (RAM 20 202 p00 p<0,0 1 9 (90 64,6 (64,6 35,4 (35,4 22,5 2 (22,5 p0 p<0, (9 64, (64, 35, (35, 22, (22, p<0 ( (64 (35 (22 p< (6 (3 (2

Abstract Background Chagas disease (CD) is a serious public health problem in Latin America. Benznidazole (BNZ) is used for the treatment of CD and, despite its wide use, little information is available about its toxicity and mechanisms of adverse drug reactions (ADR). Objectives To identify and classify clinical and laboratory adverse reactions caused by BNZ in terms of causality and severity. Methods Prospective cohort study from January 2018 to December 2021. Treatment follow-up included visits and biochemical tests (complete blood count, liver and kidney function tests) before, during and after treatment. ADR were classified according to causality and severity. In the statistical analysis, the significance level was set at p<0.05. Results Forty patients with chronic CD were included. A high prevalence of ADR was observed 161 ADR in 30 patients [90%]; of these, 104 (64.6%) were classified as possible and 57 (35.4%) as probable. The ADR were classified as moderate and mild. Of the 40 patients, nine (22.5%) discontinued treatment. ADR associated with treatment discontinuation and interventions were those that affected the dermatological system, central and peripheral nervous system and sense organs such as ageusia. Mild hematological and biochemical changes such as lymphopenia were observed after 30 days of treatment. Conclusion Many patients were able to complete the treatment even with ADR, which can be attributed to the successful follow-up strategy with symptomatic treatment and counseling, leading to patient’s awareness of symptoms and treatment adherence. (CD America (BNZ use ADR. . (ADR) severity 201 2021 followup follow up count before analysis p005 p 0 05 p<0.05 16 3 90% 90 [90%] these 10 64.6% 646 64 6 (64.6% 5 35.4% 354 35 4 (35.4% probable mild 22.5% 225 22 (22.5% ageusia counseling patient s adherence (ADR 20 202 p00 p<0.0 1 9 [90% 64.6 (64.6 35.4 (35.4 22.5 2 (22.5 p0 p<0. [90 64. (64. 35. (35. 22. (22. p<0 [9 (64 (35 (22 p< [ (6 (3 (2 (

https://doi.org/10.36660/abc.20230787

Progression of valve heart disease in a cohort of patients undergoing renal replacement therapy
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Tompson, Maria Eduarda Cavalcanti

; Pimentel, José Arthur Viana de Oliveira

; Silva, Manuella de Amorim

; Santos-Veloso, Marcelo Antônio Oliveira

; Lordsleem, Andrea Bezerra de Melo da Silveira

; Lima, Sandro Gonçalves de

Brazilian Journal of Nephrology

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Jun 2024, Volume 46 Nº 2 elocation e20230036

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Introduction: Cardiovascular disease is an important cause of death among patients with chronic kidney disease (CKD). Valve calcification is a predictor of cardiovascular mortality and coronary artery disease. Objective: To assess heart valve disease frequency, associated factors, and progression in CKD patients. Methods: We conducted a retrospective study on 291 CKD patients at Hospital das Clínicas de Pernambuco. Inclusion criteria were age ≥ 18 with CKD and valve disease, while those on conservative management or with missing data were excluded. Clinical and laboratory variables were compared, and patients were categorized by dialysis duration (<5 years; 5–10 years; >10 years). Statistical tests, including chi-square, Fisher’s exact, ANOVA, and Kruskal-Wallis, were employed as needed. Simple and multivariate binary regression models were used to analyze valve disease associations with dialysis duration. Significance was defined as p < 0.05. Results: Mitral valve disease was present in 82.5% (240) of patients, followed by aortic valve disease (65.6%; 86). Over time, 106 (36.4%) patients developed valve disease. No significant association was found between aortic, pulmonary, mitral, or tricuspid valve disease and dialysis duration. Secondary hyperparathyroidism was the sole statistically significant factor for mitral valve disease in the regression model (OR 2.59 [95% CI: 1.09–6.18]; p = 0.031). Conclusion: CKD patients on renal replacement therapy exhibit a high frequency of valve disease, particularly mitral and aortic valve disease. However, no link was established between dialysis duration and valve disease occurrence or progression. Introduction CKD. . (CKD) Objective factors Methods 29 Pernambuco 1 excluded compared <5 5 (< years 510 10 5–1 >1 years. years) tests chisquare, chisquare chi square, square chi-square Fishers Fisher s exact ANOVA KruskalWallis, KruskalWallis Kruskal Wallis, Wallis Kruskal-Wallis needed 005 0 05 0.05 Results 825 82 82.5 240 (240 65.6% 656 65 6 (65.6% 86. 86 86) time 36.4% 364 36 4 (36.4% pulmonary OR 259 2 59 2.5 95% 95 [95 CI 1.09–6.18 109618 09 1.09–6.18] 0.031. 0031 0.031 031 0.031) Conclusion However (CKD ( 51 5– > 00 0.0 8 82. 24 (24 65.6 (65.6 36.4 3 (36.4 25 2. 9 [9 1.09–6.1 10961 003 0.03 03 0. (2 65. (65. 36. (36. [ 1.09–6. 1096 (65 (36 1.09–6 109 (6 (3 1.09– 1.09 1.0 1.

Resumo Introdução: Doenças cardiovasculares são uma causa significativa de morte em pacientes com Doença Renal Crônica (DRC). A calcificação valvar é preditor de mortalidade cardiovascular e doença arterial coronariana. Objetivo: Avaliar a frequência, fatores associados e progressão de valvopatias em pacientes com DRC. Métodos: Coorte retrospectiva com 291 pacientes ambulatoriais no Hospital das Clínicas de Pernambuco. Inclusão: ≥18 anos com DRC e valvopatia; exclusão: tratamento conservador ou dados incompletos. Variáveis clínicas e laboratoriais foram comparadas e categorizadas por tempo de terapia dialítica (TTD): <5 anos, 5–10 anos, >10 anos. Foram aplicados os testes Qui-quadrado, exato de Fisher, ANOVA, Kruskal-Wallis. Associação entre valvopatia e TTD foi avaliada por regressão binária. Significância foi definida como p < 0,05. Resultados: A valvopatia mitral foi encontrada em 82,5% (240) dos casos, seguida da aórtica (65,6%; 86). Houve progressão da doença valvar em 106 (36,4%) pacientes. Não houve associação entre valvopatias aórtica, pulmonar, mitral ou tricúspide e TTD. Hiperparatireoidismo secundário foi a única variável explicativa significativa na regressão para valvopatia mitral (OR 2,59 [IC95%: 1,09–6,18]; p = 0,031). Conclusão: Encontramos alta frequência de valvopatias, especialmente mitral e aórtica, aem pacientes com DRC. Não houve associação entre TTD e valvopatia. Introdução . (DRC) coronariana Objetivo Métodos 29 Pernambuco Inclusão 18 ≥1 exclusão incompletos (TTD) 5 510 10 5–1 >1 Quiquadrado, Quiquadrado Qui quadrado, quadrado Qui-quadrado Fisher ANOVA KruskalWallis. KruskalWallis Kruskal Wallis. Wallis Kruskal-Wallis binária 005 0 05 0,05 Resultados 825 82 82,5 240 (240 casos 65,6% 656 65 6 (65,6% 86. 86 86) 36,4% 364 36 4 (36,4% pulmonar OR 259 2 59 2,5 IC95% IC95 IC [IC95% 1,09–6,18 109618 1 09 1,09–6,18] 0,031. 0031 0,031 031 0,031) Conclusão (DRC ≥ (TTD 51 5– > 00 0,0 8 82, 24 (24 65,6 (65,6 36,4 3 (36,4 25 2, IC9 [IC95 1,09–6,1 10961 003 0,03 03 0, (2 65, (65, 36, (36, [IC9 1,09–6, 1096 ( (65 (36 [IC 1,09–6 109 (6 (3 1,09– 1,09 1,0 1,

https://doi.org/10.1590/2175-8239-jbn-2023-0036en

Brazilian growth charts for Williams–Beuren Syndrome at ages 2 to 18 years WilliamsBeuren Williams Beuren 1
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Strafacci, Amanda de Sousa Lima

; Bertapelli, Fabio

; Kim, Chong Ae

; Rivadeneira, Maria José

; Honjo, Rachel Sayuri

; Kulikowski, Leslie Domenici

; Ferreira, Danilo Moretti

; Batista, Letícia Cassimiro

; Lopes, Vera Lúcia Gil da Silva

; Guerra Junior, Gil

Jornal de Pediatria

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Jun 2024, Volume 100 Nº 3 Páginas 277 - 282

Resumo: En | Texto: En | PDF: En

Abstract Objective: To develop growth charts for weight-for-age, height-for-age, and body mass index (BMI)-for-age for both genders aged 2 to 18 years for Brazilian patients with Williams-Beuren Syndrome (WBS). Methods: This is a multicenter, retrospective, and longitudinal study, data were collected from the medical records of boys and girls with a confirmed diagnosis of WBS in three large university centers in the state of Sao Paulo, Brazil. Growth charts stratified by gender and age in years were developed using LMSchartmaker Pro software. The LMS (Lambda Mu Sigma) method was used to model the charts. The quality of the settings was checked by worm plots. Results: The first Brazilian growth charts for weight-for-age, height-for-age, and BMI-for-age stratified by gender were constructed for WBS patients aged 2 to 18 years. Conclusion: The growth charts developed in this study can help to guide family members and to improve the health care offered by health professionals. Objective weightforage, weightforage weight age, weight-for-age heightforage, heightforage height height-for-age BMIforage BMI 1 WilliamsBeuren Williams Beuren WBS. . (WBS) Methods multicenter retrospective Paulo Brazil software Lambda Sigma plots Results Conclusion professionals (WBS

https://doi.org/10.1016/j.jped.2023.11.009

Acesso e cuidado a saúde de mulheres privadas de liberdade na penitenciária cearense
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Campelo, Isabella Lima Barbosa

; Bezerra, Antônio Diego Costa

; Guimarães, José Maria Ximenes

; Morais, Ana Patrícia Pereira

; Albuquerque, Grayce Alencar

; Ferreira, Regina Glaucia Lucena Aguiar

; Vieira-Meyer, Anya Pimentel Gomes Fernandes

Ciência & Saúde Coletiva

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Jun 2024, Volume 29 Nº 6 elocation e09172023

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract This study investigated access to health care among female prisoners in the state of Ceará, Brazil, and screened for common mental disorders. We conducted an analytical cross-sectional study in the only female prison in the state. Ninety detainees participated in the study. All participants were either pregnant or postpartum women or had one or more of the following health problems: hypertension, diabetes mellitus, tuberculosis, syphilis, hepatitis B, HIV/AIDS. The data were collected using a structured questionnaire. The findings reveal that access to health care was limited, violating the fundamental rights of the prisoners. Screening for diseases on admission to prison was limited, especially among non-pregnant women. Differences in health care were found between health conditions, with priority being given to pregnant and postpartum women. Most of the inmates (68.24%) were found to be at risk for common mental disorders (SRQ score > 7). A positive correlation was found between age and mental health problems (p = 0.0002). Despite legislation guaranteeing access to health care in prisons, the prison system is unprepared to meet the health needs of female prisoners with comorbidities and pregnant and puerperal women. Ceará Brazil crosssectional cross sectional hypertension mellitus tuberculosis syphilis B HIVAIDS HIV AIDS HIV/AIDS questionnaire limited nonpregnant non conditions 68.24% 6824 68 24 (68.24% SRQ 7. 7 . 7) p 0.0002. 00002 0.0002 0 0002 0.0002) prisons 68.24 682 6 2 (68.24 0000 0.000 000 68.2 (68.2 0.00 00 68. (68. 0.0 (68 0. (6 (

Resumo O estudo analisa o acesso ao cuidado em saúde de mulheres encarceradas no estado do Ceará, rastreando transtornos mentais comuns. Estudo analítico, transversal, de natureza quantitativa, desenvolvido na única penitenciária feminina do Ceará. Participaram 90 detentas, todas com alguma das seguintes questões de saúde: gestantes, puérperas, portadoras de hipertensão arterial sistêmica, diabetes mellitus, tuberculose, sífilis, hepatite B ou HIV/Aids. Os dados foram coletados por entrevista estruturada. Evidenciou-se acesso limitado à atenção à saúde das detentas, violando direitos básicos sob tutela do Estado. Foram constatadas limitações de exames de rastreamento de doenças nas presidiárias na ocasião de seu acesso ao cárcere, principalmente as que não se encontravam grávidas no momento do encarceramento. Houve diferenças entre as distintas condições de saúde analisadas, com prioridade da atenção às gestantes e puérperas. Entre as detentas, 68,24% apresentavam risco de transtornos mentais comuns (SRQ > 7). Houve correlação positiva entre idade e saúde mental (p = 0,0002). Embora exista legislação pertinente de garantia de acesso à saúde no cárcere, o sistema prisional está despreparado para atender às necessidades de portadoras de comorbidades, gestantes e puérperas. Ceará analítico transversal quantitativa 9 detentas puérperas sistêmica mellitus tuberculose sífilis HIVAids HIV Aids HIV/Aids estruturada Evidenciouse Evidenciou Estado cárcere encarceramento analisadas 6824 68 24 68,24 SRQ 7. 7 . 7) p 0,0002. 00002 0,0002 0 0002 0,0002) comorbidades 682 6 2 68,2 0000 0,000 000 68, 0,00 00 0,0 0,

https://doi.org/10.1590/1413-81232024296.09172023

Acesso e cuidado a saúde de mulheres privadas de liberdade na penitenciária cearense
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Campelo, Isabella Lima Barbosa

; Bezerra, Antônio Diego Costa

; Guimarães, José Maria Ximenes

; Morais, Ana Patrícia Pereira

; Albuquerque, Grayce Alencar

; Ferreira, Regina Glaucia Lucena Aguiar

; Vieira-Meyer, Anya Pimentel Gomes Fernandes

Ciência & Saúde Coletiva

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Jun 2024, Volume 29 Nº 6 elocation e09172023

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232024296.09172023

10.

The effectiveness of parasacral transcutaneous electrical nerve stimulation in the treatment of monosymptomatic enuresis in children and adolescents: a systematic review adolescents
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Dutra, Melissa Faria

; Bessa Junior, José de

; Almeida, Emerson Coelho Luiz de

; Lima, Eleonora Moreira

; Vasconcelos, Mônica Maria de Almeida

; Mrad, Flávia Cristina de Carvalho

International braz j urol

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Abr 2024, Volume 50 Nº 2 Páginas 136 - 151

Resumo: En | Texto: En | PDF: En

ABSTRACT Background: Parasacral Transcutaneous Electrical Nerve Stimulation (PTENS) is a treatment used in enuresis refractory to first-line treatment. This review aimed to evaluate the effectiveness of PTENS in treating monosymptomatic enuresis (MNE) in children and adolescents. Methods: The study followed the Preferred Reporting Items for Systematic (PRISMA) guidelines. The search was carried out in the following databases: MEDLINE (via PubMed), Web of Science, SCOPUS, Central Cochrane Library and Physiotherapy Evidence Database (PEDro). The selected studies were randomized clinical trials (RCTs). The "Risk of Bias tool for randomized trials" and the "Risk of Bias VISualization" were used to analyze the risk of bias. Results: Of the 624 studies selected, four RCTs were eligible. Three included 146 children and adolescents aged between six and 16.3 years and used similar PTENS protocols with a frequency of 10 Hz, pulse duration of 700 µs and 20 minutes three times/week. One study enrolled 52 patients aged seven to 14 years used PTENS at home, with a pulse duration of 200 µs and 20 to 60 minutes twice/day. Risk of bias was observed in three studies due to results’ randomization and measurement. Two studies showed a partial response with a reduction in wet nights, one a complete response in 27% of patients, and one showed no improvement. Conclusion: PTENS reduces wet nights’ frequency but does not cure them, except in 27% of patients in one study. Limited RCTs and data heterogeneity are limitations. Background (PTENS firstline first line MNE (MNE Methods PRISMA (PRISMA guidelines databases via PubMed, PubMed , PubMed) Science SCOPUS PEDro. PEDro . (PEDro) RCTs. (RCTs) VISualization Results 62 eligible 163 16 3 16. 1 Hz 70 2 timesweek times week times/week 5 home 6 twiceday twice day twice/day results measurement nights 27 improvement Conclusion them limitations (PEDro (RCTs 7

https://doi.org/10.1590/s1677-5538.ibju.2023.0618

11.

Translation, cross-cultural adaptation and validation of the Short Screening Instrument for Psychological Problems in Enuresis for use in Brazil (SSIPPE-Br) Translation crosscultural cross cultural SSIPPEBr SSIPPE Br (SSIPPE-Br
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Dias, Gláucia Cristina Medeiros

; Vasconcelos, Mônica Maria de Almeida

; Bastos Netto, José Murillo

; Miranda, Débora Marques de

; Lima, Eleonora Moreira

; Silva, Ana Cristina Simões e

; Moreira, Janaina Matos

; Mrad, Flávia Cristina de Carvalho

Jornal de Pediatria

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Abr 2024, Volume 100 Nº 2 Páginas 218 - 225

Resumo: En | Texto: En | PDF: En

Abstract Objective: Enuresis is associated with attentional and emotional comorbidities in 20 to 30 % of cases. The Short Screening Instrument for Psychological Problems in Enuresis (SSIPPE) is a questionnaire that allows the initial screening of these comorbidities. This study aimed to translate, culturally adapt, and validate the SSIPPE for Brazilian children and adolescents (SSIPPE-Br). Methods: Six steps were performed for translation and cross-cultural adaptation: translation, synthesis of translations, back-translation, preparation of the pre-final version of the translated instrument, test of comprehensibility of the pre-final version of the tool, and elaboration of the instrument cross-culturally adapted for Brazil, named 13-itens version SSIPPE-Br. To validate the SSIPPE-Br, a cross-sectional study was carried out, in which the validated Brazilian version of the Child and Adolescent Behavior Inventory (CABI) was used. Results: Validation was performed on 127 children and adolescents with a mean age of 9.7 ± 2.8 years, 48 % male. The reliability was estimated using Cronbach’s alpha, ranging from 0.86 to 0.89, indicating good internal consistency. The factorial analysis had a good agreement adjustment (KMO 0.755, Bartlett’s test < 0.001) and explained 70.5 % of the data variability. In the reproducibility analysis, the Kappa coefficient ranged from 0.94 to 1, which can be considered almost perfect. A highly significant (p-value < 0.001) and direct correlation existed between the three SSIPPE-Br domains and all evaluated CABI domains. Conclusion: The SSIPPE-Br is a valid and reliable tool for emotional problems screening and ADHD symptoms in children and adolescents with enuresis whose first language is Brazilian Portuguese. Objective 2 3 cases (SSIPPE translate adapt SSIPPEBr. SSIPPEBr Br . (SSIPPE-Br) Methods crosscultural cross cultural adaptation translations backtranslation, backtranslation back back-translation prefinal pre final crossculturally Brazil 13itens itens 13 Br. SSIPPEBr, Br, crosssectional sectional out (CABI used Results 12 97 9 7 9. 28 8 2. years 4 male Cronbachs Cronbach s alpha 086 0 86 0.8 089 89 0.89 consistency KMO 0755 755 0.755 Bartletts Bartlett 0.001 0001 001 705 70 5 70. variability 094 94 0.9 1 perfect pvalue p value Conclusion Portuguese (SSIPPE-Br 08 0. 075 75 0.75 0.00 000 00 09 07 0.7 0.0

https://doi.org/10.1016/j.jped.2023.11.001

12.

Advanced glycation end products consumption and the decline of functional capacity in patients with Parkinson's disease: Cross-sectional study Parkinsons Parkinson s disease Crosssectional Cross sectional
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Almeida, Jenifer Kristina Alves de

; Brech, Guilherme Carlos

; Luna, Natália Mariana Silva

; Iborra, Rodrigo Tallada

; Soares-Junior, Jose Maria

; Baracat, Edmund Chada

; Greve, Júlia Maria D'Andrea

; Alonso, Angélica Castilho

; Machado-Lima, Adriana

Clinics

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2024, Volume 79 elocation 100320

Resumo: En | Texto: En | PDF: En

Abstract Introduction Advanced Glycation End-Products (AGEs) are a diverse group of highly reactive molecules that play a vital role in the development of neurodegenerative disorders, such as Parkinson's Disease (PD), leading to a decline in functional and cognitive capacity. The objective of this study was to assess the intake and quantification of AGEs in individuals with PD and to correlate them with their functional and cognitive abilities. Methods This was a cross-sectional study involving 20 PD patients and 20 non-PD individuals as the Control group (C). The autofluorescence reader was used to evaluate skin AGEs, while food recall was used to quantify AGEs consumed for three different days. The Montreal Cognitive Assessment, Short Physical Performance Battery, and handgrip tests were used. PD patients demonstrated greater impairment in functional capacity compared to the control group. Results Dominant Handgrip (p = 0.02) and motor performance, in the sit and stand test (p = 0.01) and Short Physical Performance Battery (SPPB) (p = 0.01) were inferior in PD patients than the control group. Although PD patients tended to consume less AGEs than the control group, AGE intake was negatively correlated with handgrip strength in individuals with PD (r = -0.59; p < 0.05). Conclusion PD patients had lower strength and functional capacity, suggesting that the effects of AGEs might be exacerbated during chronic diseases like Parkinson's. EndProducts End Products (AGEs disorders Parkinsons Parkinson s PD, , (PD) abilities crosssectional cross sectional 2 nonPD non C. C . (C) days Assessment 0.02 002 0 02 performance 0.01 001 01 SPPB (SPPB r 0.59 059 59 -0.59 0.05. 005 0.05 05 0.05) Parkinsons. s. (PD (C 0.0 00 0.5 5 -0.5 0. -0. -0 -

https://doi.org/10.1016/j.clinsp.2023.100320

13.

Fatores associados ao policonsumo de álcool, tabaco e drogas ilícitas: Pesquisa Nacional de Saúde do Escolar 2019 álcool ilícitas 201 20 2
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Sousa, Maria das Graças de Melo

; Castro, Lucélia da Cunha

; Malta, Deborah Carvalho

; Gonçalves, Angelica Martins de Souza

; Silva Júnior, Fernando José Guedes da

; Lima, Luisa Helena de Oliveira

Ciência & Saúde Coletiva

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2024, Volume 29 Nº 5 elocation e06882023

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract The aim of this study was to analyze the factors associated with concurrent alcohol, tobacco and illicit drug use among Brazilian schoolchildren aged 13-17. We conducted a cross-sectional study using data from the 2019 National School-Based Health Survey. The outcome was use of the three substances during the last 30 days. Hierarchical multiple logistic regression was carried out with independent variables grouped into four blocks: sociodemographic characteristics; family context; behavioral aspects; and stressors. Variables with p<0.05 were retained in the final model. The prevalence of concurrent substance use was 3.3%. Being male, living in the Midwest, South and Southeast, skipping school without parent permission, parents not knowing what their children do in their free time, having parents who smoke, having experienced physical aggression from parents, feeling that life is not worth living, trying drinking and illicit drugs before the age of 13, and having friends who drink alcohol, smoke and use drugs in their presence remained associated with the outcome in the final model. The findings reveal high prevalence of concurrent alcohol, cigarette and illicit drug use among adolescents and that poly use is associated with sociodemographic, family, and behavioral factors and stressors. alcohol 1317. 1317 13 17. 17 13-17 crosssectional cross sectional 201 SchoolBased School Based Survey 3 days blocks characteristics context aspects stressors p005 p 0 05 p<0.0 model 33 3.3% male Midwest Southeast permission time 131 1 13-1 20 p00 p<0. 3.3 13- 2 p0 p<0 3. p<

Resumo Objetivou-se analisar os fatores associados ao policonsumo de álcool, tabaco e drogas ilícitas, entre adolescentes escolares brasileiros de 13 a 17 anos. Estudo transversal, com dados da Pesquisa Nacional de Saúde do Escolar (2019). A variável desfecho foi o relato de consumo das três substâncias nos últimos 30 dias. As variáveis independentes foram agrupadas em quatro blocos: características sociodemográficas; contexto familiar; situações estressoras; aspectos comportamentais. Foi realizada análise de regressão logística múltipla hierarquizada, permanecendo no modelo final as variáveis com p<0,05. A prevalência de policonsumo em adolescentes escolares foi 3,3%. No modelo final, sexo masculino, morar na região Centro-Oeste, Sul e Sudeste, faltar a escola sem permissão, pais não saberem o que fazem no tempo livre, ter pais fumantes, sofrer agressão física pelos pais, sentir que a vida não vale a pena ser vivida, experimentar bebida alcoólica e drogas ilícitas antes dos 13 anos, ter amigos que bebem bebida alcoólica, fumam e usam drogas na sua presença permaneceram associados ao desfecho. Os dados mostram alta prevalência de policonsumo de três substâncias entre adolescentes e sua associação a fatores sociodemográficos, familiares, comportamentais e a eventos estressantes. Objetivouse Objetivou se álcool 1 anos transversal 2019. 2019 . (2019) 3 dias blocos sociodemográficas familiar estressoras hierarquizada p005 p 0 05 p<0,05 33 3,3% masculino CentroOeste, CentroOeste Centro Oeste, Oeste Centro-Oeste Sudeste permissão livre fumantes vivida sociodemográficos familiares estressantes 201 (2019 p00 p<0,0 3,3 20 (201 p0 p<0, 3, 2 (20 p<0 (2 p< (

https://doi.org/10.1590/1413-81232024295.06882023

14.

Adequação do Consumo de Ácidos Graxos entre Pacientes em Prevenção Cardiovascular Secundária
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Marcadenti, Aline

; Machado, Rachel H. Vieira

; Santos, Renato Hideo Nakagawa

; Kasai, Caio Cesar dos Santos

; Kovacs, Cristiane

; Bello, Annie

; de Matos, Cristina H.

; Bertacco, Renata Torres Abib

; Souza, Gabriela C.

; Schirmann, Gabriela da S.

; Nagano, Francisca Eugenia Zaina

; Poloni, Soraia

; Kik, Raquel Milani El

; Feres, Naoel Hassan

; Rodrigues, Isa G.

; Sousa, Antônio Carlos Sobral

; Pinheiro, Josilene M. F.

; Vasconcelos, Sandra Mary Lima

; Carlos, Daniele Maria de Oliveira

; Souza, Viviane Sahade

; Gomes, Adriana Barros

; Figueiredo Neto, José Albuquerque de

; Moriguchi, Emilio Hideyuki

; Izar, Maria Cristina

; Pinto, Sônia Lopes

; Bressan, Josefina

; de Souza, Simone Raimondi

; Kumbier, Magali C.

; de Araújo, Celme Barroncas Passos

; Torreglosa, Camila R.

; Weber, Bernardete

; Bersch-Ferreira, Ângela Cristine

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 Nº 3 elocation e20230487

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Background: Adhering to a diet adequate in macronutrients is crucial for the secondary prevention of cardiovascular diseases. Objective: To assess the prevalence of adherence to recommendations for the consumption of dietary fatty acids for the prevention and treatment of cardiovascular diseases and to estimate whether the presence of certain cardiovascular risk factors would be associated with adherence. Methods: Cross-sectional study using baseline data from 2,358 participants included in the "Brazilian Cardioprotective Nutritional Program Trial". Dietary intake and cardiovascular risk factors were assessed. Adequate intake of polyunsaturated fatty acids (PUFA) was considered as ≥10% of total daily energy intake; for monounsaturated fatty acids (MUFA), 20%; and for saturated fatty acids (SFA), <7% according to the Brazilian Society of Cardiology. A significance level of 5% was considered in the statistical analysis. Results: No participant adhered to all recommendations simultaneously, and more than half (1,482 [62.9%]) did not adhere to any recommendation. Adherence exclusively to the SFA recommendation was the most prevalent, fulfilled by 659 (28%) participants, followed by adherence exclusively to the PUFA (178 [7.6%]) and MUFA (5 [0.2%]) recommendations. There was no association between the number of comorbidities and adherence to nutritional recommendations (p = 0.269). Participants from the Brazilian Northeast region showed a higher proportion of adherence to SFA consumption recommendations (38.42%) and lower adherence to PUFA intake (3.52%) (p <0.001) compared to other regions. Conclusions: Among the evaluated sample, there was low adherence to nutritional recommendations for dietary fatty acid consumption. Background Objective Methods Crosssectional Cross sectional 2358 2 358 2,35 Trial. Trial . Trial" assessed (PUFA 10 ≥10 MUFA, , (MUFA) 20% 20 SFA, (SFA) 7 <7 Cardiology 5 analysis Results simultaneously 1,482 1482 1 482 (1,48 62.9% 629 62 9 [62.9%] prevalent 65 28% 28 (28% 178 (17 7.6% 76 6 [7.6%] ( 0.2% 02 0 [0.2%] p 0.269. 0269 0.269 269 0.269) 38.42% 3842 38 42 (38.42% 3.52% 352 3 52 (3.52% <0.001 0001 001 regions Conclusions sample 235 35 2,3 ≥1 (MUFA (SFA < 1,48 148 48 (1,4 62.9 [62.9% (28 17 (1 7.6 [7.6% 0.2 [0.2% 026 0.26 26 38.42 384 4 (38.42 3.52 (3.52 <0.00 000 00 23 2, ≥ 1,4 14 (1, 62. [62.9 (2 7. [7.6 0. [0.2 38.4 (38.4 3.5 (3.5 <0.0 1, [62. [7. [0. 38. (38. 3. (3. <0. [62 [7 [0 (38 (3 <0 [6 [

Resumo Fundamento: A adesão à uma alimentação adequada em macronutrientes é fundamental para a prevenção secundária de doenças cardiovasculares. Objetivo: Avaliar a prevalência de adesão às recomendações de consumo de ácidos graxos para prevenção e tratamento de doenças cardiovasculares, e estimar se a presença de determinados fatores de risco cardiovascular estaria associada à adesão. Métodos: Estudo transversal com os dados de linha de base de 2358 participantes do estudo "Brazilian Cardioprotective Nutritional Program Trial". Dados de consumo alimentar, e fatores de risco cardiovascular foram avaliados. Foi considerada, de acordo com a Sociedade Brasileira de Cardiologia, uma ingestão adequada de ácidos graxos poli-insaturados (AGPI) ≥10% do consumo total de energia diária, para ácidos graxos monoinsaturados (AGM), 20% e para ácidos graxos saturados (AGS), <7%. Na análise estatística foi considerando nível de significância de 5%. Resultados: Nenhum participante aderiu a todas as recomendações de forma simultânea e mais da metade (1482 [62,9%]) não aderiu a nenhuma recomendação. A adesão exclusivamente à recomendação de AGS foi a mais prevalente, sendo cumprida por 659 (28%) dos participantes, seguida da adesão exclusivamente à recomendação de AGP (178 [7,6%]) e de AGM (5 [0,2%]). Não houve associação entre o número de comorbidades e a adesão às recomendações nutricionais (p =0,269). Os participantes da região Nordeste do país apresentaram maior proporção de adesão às recomendações para consumo de AGS (38,42%), e menor para ingestão de AGPI (3,52%) (p <0,001) em comparação às demais. Conclusões: Na amostra avaliada, evidenciou-se baixa adesão às recomendações nutricionais para consumo de ácidos graxos. Fundamento cardiovasculares Objetivo Métodos 235 Brazilian Trial. Trial . Trial" alimentar avaliados considerada Cardiologia poliinsaturados poli insaturados (AGPI 10 ≥10 diária AGM, , (AGM) 20 AGS, (AGS) 7 <7% 5 5% Resultados 1482 (148 62,9% 629 62 9 [62,9%] prevalente 65 28% 28 (28% 178 (17 7,6% 76 6 [7,6%] ( 0,2%. 02 0,2% 0 2 [0,2%]) p =0,269. 0269 =0,269 269 =0,269) 38,42%, 3842 38,42% 38 42 (38,42%) 3,52% 352 3 52 (3,52% <0,001 0001 001 demais Conclusões avaliada evidenciouse evidenciou 23 1 ≥1 (AGM (AGS <7 148 (14 62,9 [62,9% (28 17 (1 7,6 [7,6% 0,2 [0,2%] 026 =0,26 26 384 38,42 4 (38,42% 3,52 35 (3,52 <0,00 000 00 ≥ < 14 62, [62,9 (2 7, [7,6 0, [0,2% =0,2 38,4 (38,42 3,5 (3,5 <0,0 [62, [7, [0,2 =0, 38, (38,4 3, (3, <0, [62 [7 [0, =0 (38, (3 <0 [6 [ [0 = (38

https://doi.org/10.36660/abc.20230487

15.

The effect of biopolymer gel derived from sugarcane on healing of traumatic oral ulcers: an experimental study ulcers
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Barbosa, Lívia Mirelle

; Oliveira, Lívia Maria Lopes de

; Queiroz, Camylla Pinheiro Verissimo

; Freitas, Bruna Andrade Santos

; Lima, Tarciana Maria Pereira de

; Aguiar, José Lamartine de Andrade

; Medeiros Júnior, Martinho Dinoá

; Perez, Danyel Elias da Cruz

; Godoy, Gustavo Pina

Acta Cirúrgica Brasileira

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2024, Volume 39 elocation e390724

Resumo: En | Texto: En | PDF: En

ABSTRACT Purpose: The extracellular polysaccharide (EPS) is produced by the bacterium Zoogloea sp. and plays a positive role in tissue repair. The purpose of this study was to clinically and histologically compare the effects of EPS in the healing of traumatic oral ulcers in rats with the effects of triamcinolone. Methods: Ulcers were induced in the oral mucous of 45 male Wistar rats, divided into three groups: control group, treated with triamcinolone, and treated with biopolymer gel. In the clinical evaluation, we considered the weight variation of the animals and the size of the lesion area, at baseline and on treatment days 1, 3 and 7. The histological parameters evaluated were the type and intensity of the inflammatory infiltration, the presence of necrosis and foreign body granuloma and the degree of re-epithelialization of the lesion. Results: The reduction of the lesion area was greater in the animals treated with EPS, with no difference in the intensity of the inflammatory infiltration between the groups on days 3 and 7 of treatment. Conclusions: The results suggest that topical application of EPS in traumatic oral ulcers of rats promotes faster repair than triamcinolone ointment, without increasing the intensity of inflammatory infiltration under the lesion. Purpose (EPS sp Methods 4 group gel evaluation 1 reepithelialization re epithelialization Results Conclusions ointment

https://doi.org/10.1590/acb390724

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aff_country	código do país de afiliação do autor
aff_institution	instituição de afiliação do autor
volume	volume do artigo
issue	número do artigo
elocation	elocation
doi	número DOI
issn	ISSN da revista
in	código da coleção SciELO (ex. scl - Brasil, col - Colômbia)
use_license	código da licença de uso do artigo

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