Abstract This study explored the effects of L-PRF on pain, soft tissue healing, periodontal condition, and post-extraction bone repair of mandibular third molars (3Ms). A randomized, prospective, triple-blind, split-mouth clinical trial was conducted with 34 volunteers. Eligible patients were randomly allocated into two treatments: G1 (without L-PRF), G2 (alveoli filled with L-PRF), in which the removal of bilateral 3Ms was performed at the same surgical time. Outcomes were assessed according to a visual analogue scale (pain), soft tissue scoring system (wound healing), periodontal probing of mandibular second molar. Bone repair was determined by volumetric analysis (ITK-SNAP software) and fractal analysis (ImageJ software). An intention-to-treat approach to Statistical analysis was used. L-PRF reduced pain in the 7-day postoperative follow-up (p = 0.019) and not only improved soft tissue healing after 1 month of follow-up (p = 0.021), but also probing depth (distal face) in 3 months postoperatively (p = 0.011). Significant alveolar reduction occurred in 3 months after surgery in both treatments (p < 0.05), however, this was more significant in G1 (p = 0.016). The fractal dimension showed no statistical differences. L-PRF improved postoperative clinical parameters of pain, soft tissue healing, and periodontal condition, suggesting that it has a beneficial effect on preserving the alveolar ridge and accelerating the initial repair process. LPRF L PRF condition postextraction post extraction 3Ms. Ms . (3Ms) randomized prospective tripleblind, tripleblind triple blind, blind triple-blind splitmouth split mouth volunteers G without LPRF, , L-PRF) alveoli time (pain) wound healing) molar ITKSNAP ITK SNAP software ImageJ software. intentiontotreat intention treat used 7day day 7 followup follow up p 0.019 0019 0 019 0.021, 0021 0.021 021 0.021) distal face 0.011. 0011 0.011 011 0.011) 0.05, 005 0.05 05 0.05) however 0.016. 0016 0.016 016 0.016) differences process (3Ms (pain 0.01 001 01 002 0.02 02 00 0.0 0.

■ ABSTRACT Introduction: Complex wounds are serious tegumentary injuries that are difficult to resolve with conventional dressings. This study aimed to describe a third-intention wound healing technique, reproducible and low cost, applicable to complex wounds, using polyvinyl chloride (PVC) prosthesis temporarily placed in the injured area to promote the protection and stimulate its “granulation,” followed by autologous partial-thickness skin grafting. Method: Consecutively, 20 patients with complex wounds resulting from external causes were selected and divided into 2 groups: A - patients who underwent the coverage technique with PVC prosthesis, followed by grafting, and B - patients submitted to the care of the dressing team, with daily changes until wound granulation, standard in our institution. Patients were evaluated regarding length of stay; costs; local pain; complications; the time until medical discharge; and patient satisfaction. Results: The length of hospital stay, its costs, and the time until medical discharge were shorter in group A (p<0.05). However, there was no statistically significant difference in local pain between techniques A and B. Conclusion: The technique using PVC prosthesis and graft has good efficacy for treating complex wounds, being reproducible and inexpensive.

■ RESUMO Introdução: Feridas complexas são lesões tegumentares graves, de difícil resolução com curativos convencionais. O objetivo deste estudo foi descrever uma técnica de cicatrização de feridas por terceira intenção, reprodutível e de baixo custo, aplicável a feridas complexas, utilizando uma prótese de policloreto de vinila (PVC) colocada temporariamente na área da lesão para promover proteção e estimular sua “granulação”, seguida de enxerto autólogo de pele de espessura parcial. Método: De forma consecutiva, foram selecionados 20 pacientes com feridas complexas, decorrentes de causas externas, divididos em 2 grupos: A - pacientes que foram submetidos à técnica de cobertura com prótese de PVC, seguida de enxerto; e B - pacientes submetidos aos cuidados da equipe de curativo, com trocas diárias até granulação da ferida, padrão da nossa instituição. Os pacientes foram avaliados quanto ao tempo de internação; custos; em relação à dor local; à presença de complicações; ao tempo até a alta médica; e à satisfação do paciente. Resultados: O tempo de internamento e seus custos, assim como o tempo até a alta médica, foram menores no grupo A (p<0,05). Todavia, não houve diferença estatisticamente significativa em relação à dor local entre as técnicas A e B. Conclusão: A técnica utilizando prótese de PVC e enxerto possui boa eficácia para o tratamento de feridas complexas, sendo reprodutível e de baixo custo.

Abstract This paper presents the proposition of a set of technical and managerial actions recommended for the management of energy in industry. Economic, environmental, political and social aspects have been putting pressure on the whole society for a more conscious and efficient use and consumption of energy in its diverse forms. Energy-intensive industries show a high energy consumption, they work with processes in severe temperature conditions, residual dissipation of heat and flux of not used residues, always being subject to great environment risks. These large-sized companies offer great opportunities for making energy more efficient, use of co-generation and various other possibilities for a better management and improvement of energetic performance. The research is characterized as quali-quantitative, exploratory and descriptive, presenting a statistical analysis for the questionnaire answers. The energy management practices refer to procedures used for dealing with energetic issues. In function of the interdisciplinary aspect of energy management in the industry, the management practices can be better understood with technical and managerial continuous or frequent actions. A Delphi study for verification of the validity of the proposed technical and managerial actions was carried out together with academia and industry specialists. The results show a favorable positioning, confirmed by a reliability rate among suitable evaluators (IRR - Inter Rater Reliability). The set of technical and managerial actions is made up of reference elements for creation, organization and conduction of an energy management system in the industry. Economic environmental forms Energyintensive Energy intensive conditions residues risks largesized large sized cogeneration co generation performance qualiquantitative, qualiquantitative quali quantitative, quantitative quali-quantitative descriptive answers issues specialists positioning IRR Reliability. Reliability . Reliability) creation

A ocorrência de microepidemias de infecção pelo Trypanosoma cruzi atribuidas à ingestão de alimentos contaminados com excreta de vetores ou de reservatórios vertebrados, em áreas rurais chamou a atenção para este tipo não vetorial de transmissão da doença de Chagas. Considerando que cepas de diferentes biodemas se distribuem diferentemente nos ciclos silvestre e domiciliar de transmissão, a ocorrência de microepidemias predominantes em áreas próximas aos ecótopos silvestres pode estar relacionada com a cepa do parasito, tendo-se em conta a predominância do Biodema Tipo III, Z1 nestas áreas. No presente estudo foi investigada a infectividade de cepas do T. cruzi de diferentes biodemas quando inoculadas por via digestiva. Foi feita inoculação por via intragástrica (VIG) em camundongos Suíços com a cepa Peruana (Biodema Tipo I, Z2b) ou com a Colombiana (Biodema Tipo III, Z1, T. cruzi I). Para controle da infecção, camundongos foram também inoculados por via intraperitoneal (VIP). A cepa Colombiana mostrou alta infectividade e patogenicidade tanto por VIP como por VIG. A cepa Peruana apresentou alta infectividade e patogenicidade pela VIP e mostrou baixa infectividade pela VIG. A mais elevada infectividade pela VIG, da cepa Colombiana, cujo biodema Tipo III, Z1 é o mais freqüentemente encontrado nos hospedeiros silvestres, está de acordo com a ocorrência dos episódios epidêmicos registrados na literatura.

Oral transmission of Trypanosoma cruzi has been suspected when epidemic episodes of acute infection were observed in areas devoid of domiciled insect vectors. Considering that the distribution of T. cruzi biodemes differs in sylvatic and domestic cycles, results of studies on biodemes can be of interest regarding oral transmission. The infectivity of T. cruzi strains of different biodemes was tested in mice subjected to infection by the digestive route (gavage). Swiss mice were infected either with the Peruvian strain (Biodeme Type I, Z2b) or the Colombian strain (Biodeme Type III, Z1, or T. cruzi I); for control, intraperitoneal inoculation was performed in a group of mice. The Colombian strain revealed a similar high infectivity and pathogenicity when either route of infection was used. However, the Peruvian strain showed contrasting levels of infectivity and pathogenicity, being high by intraperitoneal inoculation and low when the gastric route was used. The higher infectivity of the Colombian strain (Biodeme Type III) by gastric inoculation is in keeping with its role in the epidemic episodes of acute Chagas disease registered in the literature, since strains belonging to Biodeme III are most often found in sylvatic hosts.