RESUMO O presente estudo teve por objetivo analisar a exposição aos agrotóxicos e os danos à saúde dos trabalhadores das plantações de cana-de-açúcar em Pernambuco. Trata-se de pesquisa participante desenvolvida em territórios rurais de cinco municípios com forte expressão em área plantada de cana-de-açúcar. Os dados primários foram produzidos em oficinas com trabalhadores rurais para construção de diagnóstico rural participativo, analisados mediante condensação de significados e interpretados à luz do referencial teórico da epidemiologia crítico latino-americana. Os resultados estão apresentados em três seções: i) Fluxograma do trabalho nas plantações de cana-de-açúcar; ii) Exposição aos agrotóxicos utilizados nas lavouras; iii) Danos à saúde do trabalhador. Conclui-se que a exposição permanente aos agrotóxicos envolve o trabalho nas plantações de cana-de-açúcar e emerge de um construto histórico e socioambiental, em que se encontram subsumidos os modos de vida dos territórios sob o domínio do agronegócio canavieiro. Recomendam-se políticas públicas de fomento à agricultura familiar com diversificação, escoamento e distribuição da produção agroecológica, além do fortalecimento da Atenção Primária à Saúde e de ações integradas de vigilância epidemiológica, sanitária, ambiental e do trabalhador. canadeaçúcar cana açúcar Pernambuco Tratase Trata canadeaçúcar. açúcar. participativo latinoamericana. latinoamericana latino americana. americana latino-americana seções i ii lavouras iii trabalhador Concluise Conclui socioambiental canavieiro Recomendamse Recomendam diversificação agroecológica epidemiológica sanitária

ABSTRACT This study aims to analyze exposure to pesticides and harm to the health of workers on sugarcane plantations in Pernambuco. This participatory research was conducted in rural territories of five municipalities with a strong presence in sugarcane-planted areas. The primary data were produced in workshops with rural workers to construct a participatory rural diagnosis, analyzed through condensation of meanings, and interpreted in light of the theoretical framework of Latin American critical epidemiology. The results are presented in three sections: i) Flowchart of work on sugarcane plantations; ii) Exposure to pesticides used on crops; iii) Harm to worker’s health. We conclude that permanent exposure to pesticides involves working on sugarcane plantations and emerges from a historical and socio-environmental construct in which the ways of life of the territories under the control of sugarcane agribusiness are subsumed. Public policies are recommended to promote family farming with diversification, flow, distribution of agroecological production, and strengthening primary health care and integrated epidemiological, health, environmental, and worker surveillance actions. Pernambuco sugarcaneplanted planted areas diagnosis meanings epidemiology sections i ii crops iii s socioenvironmental socio environmental subsumed diversification flow production epidemiological actions

ABSTRACT This study aims to analyze exposure to pesticides and harm to the health of workers on sugarcane plantations in Pernambuco. This participatory research was conducted in rural territories of five municipalities with a strong presence in sugarcane-planted areas. The primary data were produced in workshops with rural workers to construct a participatory rural diagnosis, analyzed through condensation of meanings, and interpreted in light of the theoretical framework of Latin American critical epidemiology. The results are presented in three sections: i) Flowchart of work on sugarcane plantations; ii) Exposure to pesticides used on crops; iii) Harm to worker’s health. We conclude that permanent exposure to pesticides involves working on sugarcane plantations and emerges from a historical and socio-environmental construct in which the ways of life of the territories under the control of sugarcane agribusiness are subsumed. Public policies are recommended to promote family farming with diversification, flow, distribution of agroecological production, and strengthening primary health care and integrated epidemiological, health, environmental, and worker surveillance actions.

RESUMO O presente estudo teve por objetivo analisar a exposição aos agrotóxicos e os danos à saúde dos trabalhadores das plantações de cana-de-açúcar em Pernambuco. Trata-se de pesquisa participante desenvolvida em territórios rurais de cinco municípios com forte expressão em área plantada de cana-de-açúcar. Os dados primários foram produzidos em oficinas com trabalhadores rurais para construção de diagnóstico rural participativo, analisados mediante condensação de significados e interpretados à luz do referencial teórico da epidemiologia crítico latino-americana. Os resultados estão apresentados em três seções: i) Fluxograma do trabalho nas plantações de cana-de-açúcar; ii) Exposição aos agrotóxicos utilizados nas lavouras; iii) Danos à saúde do trabalhador. Conclui-se que a exposição permanente aos agrotóxicos envolve o trabalho nas plantações de cana-de-açúcar e emerge de um construto histórico e socioambiental, em que se encontram subsumidos os modos de vida dos territórios sob o domínio do agronegócio canavieiro. Recomendam-se políticas públicas de fomento à agricultura familiar com diversificação, escoamento e distribuição da produção agroecológica, além do fortalecimento da Atenção Primária à Saúde e de ações integradas de vigilância epidemiológica, sanitária, ambiental e do trabalhador.

Abstract Objective The purpose of this study was to evaluate the clinical-epidemiological profile, associated risk factors and clinical outcomes of patients with acute myeloid leukemia (AML), identifying the main causes of morbidity and mortality and overall survival rate of patients at five years of follow-up. Method This was a retrospective cohort study evaluating the prognosis and clinical outcomes of 222 patients diagnosed with AML at three large hematology centers in Ceará (northeastern Brazil) over a period of five years. Results The mean age at diagnosis was 44.1 ± 16 years, with a female prevalence of 1.3:1. No additional relevant risk factors associated with the development of AML were found, except for the well-established cytogenetic assessment. The overall 5-year survival rate was 39.4% (95%CI: 35.47 - 42.17). The main causes of death were disease progression (37.72%; n = 84) and sepsis (31.58%; n = 70). Conclusion The clinical outcomes in our sample of AML patients were similar to those of other reported groups. Disease progression and infection were the main causes of death. Access to diagnostic flow cytometry and karyotyping was greater in our sample than in the national average. As expected, overall survival differed significantly according to the risk, as determined by cytogenetic testing. clinicalepidemiological epidemiological profile AML, , (AML) followup. followup follow up. up follow-up 22 northeastern Brazil 441 44 1 44. 1.31. 131 1.3 1. 3 1.3:1 found wellestablished well established assessment 5year year 5 394 39 4 39.4 95%CI 95CI CI 95 (95%CI 3547 35 47 35.4 42.17. 4217 42.17 . 42 17 42.17) 37.72% 3772 37 72 (37.72% 84 31.58% 3158 31 58 (31.58% 70. 70 70) groups average expected testing (AML 2 1.31 13 1.3: 39. 9 354 35. 421 42.1 37.72 377 7 (37.72 8 31.58 315 (31.58 42. 37.7 (37.7 31.5 (31.5 37. (37. 31. (31. (37 (31 (3 (

Aim To evaluate the surface roughness and color stability of bulk-fill resin composites after simulated toothbrushing with whitening dentifrices. The radioactive/relative dentin abrasion (RDA) and radioactive/relative enamel abrasion (REA) of dentifrices were also assessed. Methods Specimens (n=10) of Tetric N Ceram Bulk Fill (TNCB), Filtek One Bulk Fill (FOB) resin composites, and Z100(Control) were prepared using a cylindrical Teflon matrix. Surface roughness (Ra, μm) was assessed by a roughness meter and the color evaluations (ΔEab, ΔE00, WID) were performed using a digital spectrophotometer based on the CIELAB system. Three measurements were performed per sample, before and after simulated toothbrushing with 3D Oral-B White Perfection (3DW) and Black is White (BW) dentifrices. The abrasivity (REA and RDA values) of the used dentifrices was also determined by the Hefferren abrasivity test. Results The Ra values increased significantly in all resin composites after 3DW and BW toothbrushing. The acceptable threshold color varied among resin composites, and TNCB and Z100 presented the highest ΔEab and ΔE00 for BW dentifrice. The 3DW dentifrice was significantly more abrasive than BW dentifrice on enamel and dentin. Conclusions simulated toothbrushing with tested whitening dentifrices increased the surface roughness at acceptable levels. The Tetric N Ceram Bulk-fill and Z100 composite showed the highest color alteration in BW. 3D White Perfection dentifrice was more abrasive on dentin and enamel than Black is White. bulkfill bulk fill radioactiverelative radioactive relative (RDA REA n=10 n10 n 10 (n=10 TNCB, , (TNCB) FOB (FOB Z100Control ZControl Control Z Z100(Control matrix Ra, (Ra μm ΔEab, (ΔEab ΔE WID system sample D OralB Oral B DW (3DW (BW test Z10 ΔE0 levels Bulkfill n=1 n1 1 (n=1 (TNCB Z1 n= (n= (n

Resumen Objetivo Proponer un diagrama de prevención de caídas para personas mayores, basado en el modelo de promoción de la salud de Nola Pender. Métodos La elaboración del diagrama se basó en el modelo de Nola Pender y sus elementos. Para tal fin, se realizó un estudio de revisión integradora con el objetivo de recopilar datos sobre características y experiencias individuales, sentimientos y conocimientos y adopción de un comportamiento saludable para la prevención de caídas. Después de recopilar la información, se realizó un análisis de similitud de los estudios seleccionados mediante IRaMuTeQ. Los elementos obtenidos del análisis de similitud permitieron agrupar los estudios respecto a los elementos encontrados y, de esta forma, proporcionaron la organización del diagrama de prevención de caídas. Resultados La muestra final estuvo compuesta por 54 artículos, divididos de acuerdo con los elementos del modelo de Nola Pender: 36 abordaban características y experiencias individuales, 40 sentimientos y conocimientos y 20 eran sobre el comportamiento. Los elementos obtenidos del análisis de similitud generaron un conjunto semántico de palabras más frecuentes: caída, prevención, mujer y miedo. Por otro lado, las palabras menos frecuentes fueron: cognición, autoeficacia, transporte y planificación, que contribuyeron para la elaboración del diagrama. Conclusión A partir de la revisión, se elaboró un diagrama que favoreció la identificación de los factores personales, barreras y facilidades para un comportamiento conveniente en la prevención de caídas. mayores fin individuales información IRaMuTeQ forma 5 artículos 3 4 2 caída miedo lado fueron cognición autoeficacia planificación personales

Abstract Objective To propose a fall prevention diagram for older adults, based on Nola Pender’s Health Promotion Model. Methods Diagram construction was based on Nola Pender’s model and its elements. For this, an integrative review study was carried out with the objective of collecting data on individual characteristics and experiences, behavior-specific cognitions and affect and behavioral outcome for fall prevention. After collecting this information, a similarity analysis of the selected studies was carried out using IRaMuTeQ. The elements obtained from similarity analysis facilitated the grouping of studies regarding the elements found and thus provided fall prevention diagram organization. Results The final sample consisted of 54 articles, divided according to the elements of Nola Pender’s model: 36 addressed individual characteristics and experiences, 40 referred to behavior-specific cognitions and affect, and 20 referred to behavioral outcome. The elements obtained from the similarity analysis generated a semantic range of the most frequent words: fall, prevention, woman and fear. The least frequent words were cognition, self-efficacy, transportation and planning, which contributed to diagram construction. Conclusion From the review, a diagram was prepared, which favored identifying personal factors, barriers and facilities for a desirable behavior to prevent falls. adults Penders Pender s Model experiences behaviorspecific specific information IRaMuTeQ organization 5 articles 3 4 2 fear cognition selfefficacy, selfefficacy self efficacy, efficacy self-efficacy planning prepared factors falls

Resumo Objetivo Propor um diagrama de prevenção de quedas para pessoas idosas, baseado no Modelo de Promoção da Saúde de Nola Pender. Métodos A construção do diagrama foi embasada no modelo de Nola Pender e em seus elementos. Para isso, foi realizado um estudo de revisão integrativa, com o objetivo de coletar dados sobre características e experiências individuais, sentimentos e conhecimentos e adoção de comportamento saudável para prevenção de quedas. Após a coleta dessas informações, realizou-se análise de similitude dos estudos selecionados por meio do IRaMuTeQ. Os elementos obtidos da análise de similitude facilitaram o agrupamento dos estudos quanto aos elementos encontrados e, assim, proporcionaram a organização do diagrama de prevenção de quedas. Resultados A amostra final foi constituída de 54 artigos, divididos de acordo com os elementos do modelo de Nola Pender: 36 abordavam características e experiências individuais, 40 sentimentos e conhecimentos, e 20 eram referentes ao comportamento. Os elementos obtidos da análise de similitude geraram um leque semântico de palavras mais frequentes: queda, prevenção, mulher e medo. Já as palavras menos frequentes foram cognição, autoeficácia, transporte e planejamento, os quais contribuíram para a construção do diagrama. Conclusão A partir da revisão, elaborou-se um diagrama, que favoreceu a identificação dos fatores pessoais, barreiras e facilidades, para um comportamento desejável à prevenção de quedas. idosas isso integrativa individuais informações realizouse realizou se IRaMuTeQ assim 5 artigos 3 4 2 queda medo cognição autoeficácia planejamento elaborouse elaborou pessoais facilidades

RESUMEN Objetivo: Informar sobre las adaptaciones realizadas a la Técnica de Grupo Nominal (TGN) original, permitiendo su aplicación al formato virtual, preservando todos sus elementos clave. Método: Se trata de un informe de experiencia sobre las adaptaciones y ajustes realizados a la TGN original para el formato virtual mediante el uso de las Tecnologías de la Información y la Comunicación (TIC), utilizando herramientas digitales disponibles de forma gratuita o de bajo coste y fácil uso. Resultados: El TGN se realizó íntegramente de manera virtual y sufrió adaptaciones en cada una de sus cuatro etapas mediante la incorporación de recursos digitales específicos. Fue posible presentar las ideas más votadas y obtener la aprobación final de los participantes. Los participantes no tuvieron dificultades para utilizar los recursos virtuales proporcionados y, según los comentarios recibidos, se mostraron satisfechos con las herramientas facilitadas. Conclusión: El TGN adaptado demostró ser un método eficaz cuando se utiliza en un entorno virtual, capaz de producir un número significativo de ideas y desarrollar el consenso. La herramienta adaptada puede ser utilizada por otros investigadores en países con recursos o dimensiones similares a las de Brasil. Objetivo (TGN clave Método TIC, TIC , (TIC) Resultados específicos recibidos facilitadas Conclusión consenso Brasil (TIC

ABSTRACT Objective: To report on the adaptations made to the original Nominal Group Technique (NGT), allowing it to be applied to the virtual format, preserving all its key elements. Method: An experience report on the adaptations and adjustments made to the original NGT to the virtual format using Information and Communication Technologies (ICT), using digital tools that are available free of charge or are low cost and easy to use. Results: The NGT was carried out entirely virtually and underwent adaptations in each of its four stages through the incorporation of specific digital resources. It was possible to present the most voted ideas and obtain final approval from the participants. The participants had no difficulty in using the virtual resources provided and, based on the reaction evaluation, they were satisfied with the tools provided. Conclusion: The adapted NGT proved to be an effective method when used in a virtual setting, capable of producing a significant number of ideas and developing consensus. The adapted tool can be used by other researchers in countries with similar resources or dimensions to Brazil. Objective NGT, , (NGT) elements Method ICT, ICT (ICT) use Results evaluation Conclusion setting consensus Brazil (NGT (ICT

RESUMO Objetivo: Relatar as adaptações realizadas na Técnica de Grupo Nominal (TGN) original, permitindo sua aplicação ao formato virtual, preservando todos os seus elementos-chave. Método: Relato de experiência sobre as adaptações e adequações realizadas na TGN original ao formato virtual aplicando as Tecnologias da Informação e Comunicação (TIC), por meio de ferramentas digitais disponibilizadas gratuitamente ou de baixo custo e de fácil manejo. Resultados: A TGN foi realizada integralmente de forma virtual e sofreu adaptações em cada uma das suas quatro etapas através da incorporação de recursos digitais específicos. Foi possível apresentar as ideias mais votadas e obter a aprovação final dos participantes. Os participantes não apresentaram dificuldade para utilizar os recursos virtuais disponibilizados, e, partir da avaliação de reação, mostram-se satisfeitos com as ferramentas disponibilizadas. Conclusão: A TGN adaptada mostrou-se um método efetivo quando utilizada em cenário virtual, sendo capaz de produzir um significativo número de ideias e desenvolver consenso. A ferramenta adaptada pode ser usada por outros pesquisadores em países com recursos ou dimensões semelhantes ao Brasil. Objetivo (TGN elementoschave. elementoschave elementos chave. chave elementos-chave Método TIC, TIC , (TIC) manejo Resultados específicos disponibilizados reação mostramse mostram se Conclusão mostrouse mostrou consenso Brasil (TIC

Scaffolds are devices with interconnected pores that favor cell interaction and proliferation. They play a significant role in tissue engineering, as they mimic the conditions of tissue production in vivo. The aim of this study was to synthesize scaffolds of chitosan, collagen, and Jatropha mollissima by lyophilization and characterize their chemical/biodegradability and morphological properties. For that, techniques of optical microscopy, infrared spectrometry, biodegradation test, and degree of swelling were performed. A 2% (m/v) chitosan/collagen (1:9) in lactic acid solution was produced. Then, Jatropha mollissima crude extract was added to this solution in different proportions of mass (5, 10, and 15%). Optical microscope images indicated the three-dimensional network formation with interconnected pores and predominantly lamellar shape. Through infrared spectrometry, characteristic bands indicated a physical mixture. Also, the swelling degree of all samples was proportional to the amount of Jatropha mollissima extract with the highest percentage of 1852%. Biodegradation test also revealed a proportional ratio between the amount of sap used and the degraded percentage with the lowest value of around 35% in 28 days. In conclusion, it can be inferred that the scaffolds produced show potential to be used in tissue engineering as dressings. proliferation vivo chitosan collagen chemicalbiodegradability chemical biodegradability properties microscopy spectrometry performed 2 m/v mv m v (m/v chitosancollagen 19 1 9 (1:9 Then 5, 5 (5 10 15%. 15 15% . 15%) threedimensional three dimensional shape mixture Also 1852 1852% 35 days conclusion dressings (1: ( 185 3 (1 18

Abstract Objective To evaluate the quality of primary healthcare services for older adults during the COVID-19 pandemic through studies evaluating health services. Method A systematic literature review was conducted. The search for articles covered the databases Web of Science, Embase, Scopus, and Medline/Pubmed. Original scientific articles with a case-control or cross-sectional design, involving populations that included older adults, focusing on primary healthcare, and assessing the quality of health services were included. Exclusion criteria were studies without specific analysis for older adults, studies evaluating health access or economic evaluation of health. The risk of bias analysis was conducted according to JBI protocols, and data synthesis was performed using SWiM guidelines. Results Seven studies were included in the review. The primary care services evaluated were mostly outpatient, with diverse quality assessment parameters related to individual care. The evaluation of quality identified a decrease in in-person consultations and visits, and an increase in the use of telehealth, with good satisfaction ratings among older adults. Conclusion The studies highlighted the difficulties maintaining and accessing in-person services during the COVID-19 pandemic, which directly contributed to a reduction in consultations and exams, usage of and access to health services, and the quality of primary healthcare. COVID19 COVID 19 COVID-1 Science Embase Scopus MedlinePubmed Medline Pubmed Medline/Pubmed casecontrol case control crosssectional cross sectional design protocols guidelines outpatient inperson person visits telehealth exams COVID1 1 COVID-

Resumo Objetivo Avaliar a qualidade da atenção primária à saúde voltada para pessoas idosas, durante a pandemia de covid-19, por meio de estudos de avaliação de serviços de saúd Método Foi realizada uma revisão sistemática da literatura. A busca de artigos abrangeu as bases de dados Web of Science, Embase, Scopus e Medline/Pubmed. Foram incluídos artigos científicos originais, com desenho, caso-controle ou seccional, população contendo pessoas idosas, objeto do estudo atenção primária à saúde e estudos sobre a qualidade dos serviços de saúde. Os critérios de exclusão adotados foram: estudos sem análise específica para idosos, estudos de avaliação do acesso ou avaliação econômica da saúde. A análise do risco de viés foi realizada de acordo com os protocolos JBI e a síntese de dados foi realizada com as diretrizes SWiM. Resultados Foram incluídos na revisão sete estudos. Os serviços de atenção primária avaliados foram, em sua maioria, ambulatoriais, com parâmetros de avaliação da qualidade diversos, relacionados ao cuidado individual. A avaliação da qualidade identificou diminuição de consultas e visitas presenciais e aumento do uso de telessaúde, com boa avaliação da satisfação por pessoas idos Conclusão Os estudos evidenciaram as dificuldades na manutenção e no acesso aos serviços presenciais durante a pandemia de covid-19, o que impactou diretamente na redução da oferta de consultas e exames, na utilização e acesso aos serviços de saúde e na qualidade da assistência à saúde na atenção primária. idosas covid19, covid19 covid 19, 19 covid-19 literatura Science Embase MedlinePubmed Medline Pubmed Medline/Pubmed originais desenho casocontrole caso controle seccional foram idosos SWiM maioria ambulatoriais diversos individual telessaúde exames covid1 1 covid-1 covid-

ABSTRACT In recent years the concern of environmentalists has been growing due to the large use of products that have non-renewable fossil sources as raw material. An alternative adopted by the researchers is the production of thermoplastic matrix composites with lignocellulosic waste fibers. The oticica or oiti is a fruit rich in oil and is widely used for soap production. The co-product generated from this process is rich in fiber, oil and impurities and is currently widely used for animal feed and soil fertilizer. The objective of the present work is the production and evaluation of the properties of HDPE composites with Oiticica waste. As matrix was used a green HDPE supplied by Braskem and the dispersed phase was the pie de oiticica supplied by a soap factory. Compositions with 5, 10 and 20% of waste de oiticica were processed by double screw extrusion and the specimens made by the injection process. The composites were characterized by uniaxial tensile test to evaluate mechanical properties (deformation to rupture, modulus, and stress at maximum force). The interaction between pie and matrix was analyzed through the fracture surface using scanning electron microscopy and the analysis. Thermal analysis was assessed by DSC. The results showed decrease in the deformation for 10 and 20% waste compositions. There was a gradual decrease at the stress at the maximum strength of the composites when compared to HDPE. The micrographs showed little interaction between fiber and matrix and the presence of voids. Thermal analysis showed a decrease in the degree of crystallinity, concluding that the presence of the oiticica may have made it difficult to organize the chains, generating a greater number of amorphous regions. nonrenewable non renewable material fibers coproduct co product fertilizer factory 5 1 20 rupture modulus force. force . force) DSC compositions voids crystallinity chains regions 2

RESUMO Nos últimos anos a preocupação de ambientalistas vem crescendo devido ao grande uso de produtos que tem como matéria-prima fontes fósseis não renováveis. Uma alternativa adotada entre os pesquisadores é a produção de compósitos de matriz termoplástica com fibras de resíduos de lignocelulósicas. A oiticica ou oiti é um fruto rico em óleo e é muito utilizado para a produção de sabão. O co-produto gerado desse processo é rico em fibras, óleo e impurezas e atualmente é muito utilizado para ração animal e adubo para solo. O objetivo do presente trabalho é a produção e avaliação das propriedades de compósitos de PEAD com Torta de Oiticica. Como matriz foi utilizado um PEAD verde fornecido pela Braskem e a fase dispersa foi a Torta de oiticica fornecida por uma fábrica de sabão. As composições com 5, 10 e 20% de Torta de oiticica foram processadas por extrusão dupla rosca e os corpos de provas confeccionados pelo processo de injeção. Os compósitos foram caracterizados através do ensaio de tração uniaxial para avaliação de propriedades mecânicas (deformação até a ruptura, módulo e tensão na força máxima). A interação entre torta e matriz foi analisada através da superfície de fratura utilizando microscopia eletrônica de varredura e a análise térmica foi avaliada através de DSC. Os resultados mostraram diminuição na deformação para composições com 10 e 20% de torta. Houve uma queda gradativa na tensão na força máxima nos compósitos quando comparada com a do PEAD. As micrografias mostraram pouca interação entre fibra e matriz e a presença de vazios. As análises térmicas apresentaram uma diminuição no grau de cristalinidade. concluindo-se que a presença da torta pode ter dificultado a organização das cadeias, gerando maior número de regiões amorfas. matériaprima matéria prima renováveis lignocelulósicas sabão coproduto co produto solo Oiticica 5 1 20 injeção ruptura máxima. . máxima) DSC vazios cristalinidade concluindose concluindo se cadeias amorfas 2

Abstract Laterite gravels have been successfully adopted as pavement materials in the field. Despite that, they are often rejected in material selection processes because of its base on traditional gradation and consistency limits requirements. To allow a deeper evaluation of such material found abundantly in tropical countries, along to characterizing traditional parameters, repeated load triaxial tests were performed in a Laterite Gravel from Acre/Brazil to evaluate its elastic and plastic behavior through Resilient Modulus (RM) and Permanent Deformation (PD), respectively. In addition, a simulation was conducted in the MeDiNa software, based on the test results considering stress states that are usually applied in pavement layers. The material showed RM values higher than 500 MPa, which was considered high compared to materials such as Quartz and Granite. It was also observed low permanent deformation (below 1 mm for higher tensions applied) and accommodation of displacement (shakedown) for most specimens. The simulation results showed low rutting prediction for the Laterite Gravel applied in highway pavement layers. Thus, the results indicated that the lateritic gravel can be adopted in the composition of base or subbase layers of flexible pavements, even though some limits of the parameters specified by traditional specifications were violated, as expected. In addition, we also highlight the need for adoption of new material selection strategies that are based on key mechanical characteristics to avoid discarding potentially well performing materials. field requirements countries AcreBrazil Acre Brazil (RM PD, PD , (PD) respectively addition software 50 MPa Granite below shakedown (shakedown specimens Thus pavements violated expected (PD 5

ABSTRACT The global reemergence of measles in 2018–2019 reinforces the relevance of high-coverage immunization to maintain the disease elimination. During an outbreak in the Sao Paulo State in 2019, several measles cases were reported in individuals who were adequately vaccinated according to the current immunization schedule recommends. This study aimed to assess measles IgG antibody seropositivity and titers in previously vaccinated adults. A cross-sectional study was conducted at CRIE-HC-FMUSP (Sao Paulo, Brazil) in 2019. It included healthy adults who had received two or more Measles-Mumps-Rubella vaccines (MMR) and excluded individuals with immunocompromising conditions. Measles IgG antibodies were measured and compared by ELISA (Euroimmun®) and chemiluminescence (LIASON®). The association of seropositivity and titers with variables of interest (age, sex, profession, previous measles, number of measles-containing vaccine doses, interval between MMR doses, and time elapsed since the last MMR dose) was analyzed. A total of 162 participants were evaluated, predominantly young (median age 30 years), women (69.8%) and healthcare professionals (61.7%). The median interval between MMR doses was 13.2 years, and the median time since the last dose was 10.4 years. The seropositivity rate was 32.7% by ELISA and 75.3% by CLIA, and a strong positive correlation was found between the tests. Multivariate analyses revealed that age and time since the last dose were independently associated with positivity. Despite being a single-center evaluation, our results suggest that measles seropositivity may be lower than expected in adequately immunized adults. Seropositivity was higher among older individuals and those with a shorter time since the last MMR vaccine dose. 20182019 2018 2019 2018–201 highcoverage high coverage elimination recommends crosssectional cross sectional CRIEHCFMUSP CRIE HC FMUSP Brazil MeaslesMumpsRubella Mumps Rubella (MMR conditions Euroimmun® Euroimmun (Euroimmun® LIASON®. LIASON LIASON® . (LIASON®) age, (age sex profession measlescontaining containing analyzed 16 evaluated 3 years , years) 69.8% 698 69 8 (69.8% 61.7%. 617 61.7% 61 7 (61.7%) 132 13 2 13. 104 10 4 10. 327 32 32.7 753 75 75.3 CLIA tests positivity singlecenter single center evaluation 2018201 201 2018–20 (Euroimmun (LIASON® 1 69.8 6 (69.8 61.7 (61.7% 32. 75. 201820 20 2018–2 (LIASON 69. (69. 61. (61.7 20182 2018– (69 (61. (6 (61 (

ABSTRACT Objective: To identify online recommendations from pediatric and pediatric dentistry associations of the Americas regarding the pacifier habit. Material and Methods: A search was conducted on the associations' website (November/2021 to March/2023) to the questions: (1) Recommend using a pacifier?, (2) What care?, (3) Advantages and (4) disadvantages, (5) Ideal age, and (6) methods for habit removal. Results: Among the 36 American countries, 21 were represented on websites, social media, and official guides. The most significant portion of pediatric dentistry associations (23.81%) does not recommend the use of a pacifier if the infant is exclusively breastfeeding, and recommends avoiding the offer of a pacifier in the first days of life to facilitate the establishment of breastfeeding. Some pediatric (29.63%) associations suggested that use reduces the risk of sudden infant death syndrome. Most pediatric dentistry associations (85.71%) and some pediatric associations (22.22%) linked pacifier use to breastfeeding difficulties and the occurrence of orthodontics. Most of the 20 pediatric dentistry associations stated that the habit should be removed by a maximum of three years of age (90.48%). The most reported recommendations were behavior modification techniques and positive reinforcement. Conclusion: Most pediatric dentistry associations recommend the care and disadvantages of pacifiers and the ideal age to remove them. The few pediatric associations that provide information address indications, care, advantages and disadvantages of pacifiers, age, and methods for removing them. Objective Methods November/2021 November2021 November 2021 (November/202 March/2023 March2023 March 2023 questions 1 (1 pacifier, , pacifier? 2 (2 care? 3 (3 4 (4 5 (5 6 (6 removal Results countries websites media guides 23.81% 2381 23 81 (23.81% 29.63% 2963 29 63 (29.63% syndrome 85.71% 8571 85 71 (85.71% 22.22% 2222 22 (22.22% orthodontics 90.48%. 9048 90.48% . 90 48 (90.48%) reinforcement Conclusion them indications November/202 November202 202 (November/20 March/202 March202 ( 23.81 238 8 (23.81 29.63 296 (29.63 85.71 857 7 (85.71 22.22 222 (22.22 904 90.48 9 (90.48% November/20 November20 (November/2 March/20 March20 23.8 (23.8 29.6 (29.6 85.7 (85.7 22.2 (22.2 90.4 (90.48 November/2 November2 (November/ March/2 March2 23. (23. 29. (29. 85. (85. 22. (22. 90. (90.4 November/ (November March/ (23 (29 (85 (22 (90. (8 (90 (9

ABSTRACT The areas of Amazonian floodplains have added ecological value to their multiple ecosystem services, including water supply, local climate regulation, biodiversity with a marked number of endemic species, and diversity of micro-habitat. Considering the importance of conserving these environments, this study aimed to analyze the behavior and delimit the areas of the natural distribution of forest species Alchornea castaneifolia (Willd.) A. Juss and Laetia corymbulosa (lowland low), Maquira coriacea (H.Karst.) C.C. Berg (Moraceae), and Ocotea cymbarum Kunth (high floodplain), besides evaluating the potential impacts of climate change on the future distribution inferring on its conservation. The potential species distribution was modeled using Environmental Modelling & Software, by employing algorithms such as Bioclim, Domain, Maximum Entropy, Random Forests, and Support Vector Machine (SVM). The projections indicate that climate change threatens the occurrence of floodplain species. Under the SSP 585 scenario for both periods, the four species studied will lose areas of climatic adequacy until the end of the 21st century, especially in the Brazilian Amazon. The study shows the need to increase socio-environmental responsibility through conserving current protected areas in freshwater ecosystems and implementing new priority areas for conserving wetlands (Ramsar Sites) in the Amazon. Such measures are essential to ensure in situ conservation and protect them from habitat loss. services supply regulation microhabitat. microhabitat micro habitat. micro-habitat environments Willd. Willd (Willd. A lowland low, low , low) H.Karst. HKarst H Karst (H.Karst. CC C C.C Moraceae, Moraceae (Moraceae) high floodplain, floodplain) Software Bioclim Domain Entropy Forests SVM. SVM . (SVM) 58 periods st century Amazon socioenvironmental socio environmental Ramsar Sites loss (Willd H.Karst (H.Karst (Moraceae (SVM 5

RESUMO As áreas de várzeas amazônicas possuem valor ecológico agregado aos seus múltiplos serviços ecossistêmicos, incluindo o abastecimento de água, regulagem do clima local, biodiversidade com um número acentuado de espécies endêmicas e com diversidade de micro-habitat. Considerando a importância da conservação desses ambientes, este estudo objetivou analisar o comportamento e delimitar as áreas de distribuição natural das espécies florestais Alchornea castaneifolia (Willd.) A. Juss e Laetia corymbulosa (várzea baixa) e Maquira coriacea (H. Karst.) C.C. Berg (Moraceae) e Ocotea cymbarum Kunth (várzea alta), além de avaliar os impactos potenciais das mudanças climáticas sobre a distribuição futura, inferindo sobre a sua conservação. A modelagem de distribuição potencial das espécies foi feita com o uso do Environmental Modelling & Software, a partir dos algoritmos como: Bioclim, Domain, Maximum Entropy, Random Forests e Support Vector Machine (SVM). As projeções indicam que as mudanças climáticas representam ameaça à ocorrência das espécies de várzea. Sob o cenário SSP 585 para ambos os períodos, as quatro espécies estudadas perderão áreas de adequação climática até o final do século XXI, principalmente, na Amazônia brasileira. O estudo mostra a necessidade de aumentar a responsabilidade socioambiental para conservação das áreas protegidas atuais em ecossistemas de água doce e, implementar novas áreas prioritárias para a conservação de zonas úmidas (Sítios Ramsar) na Amazônia. Tais medidas são fundamentais para garantir a conservação in situ e protegê-las de uma perda de habitat. ecossistêmicos local microhabitat. microhabitat micro habitat micro-habitat ambientes Willd. Willd (Willd. várzea baixa H. H (H Karst. Karst CC C C.C Moraceae (Moraceae alta, alta , alta) futura Software como Bioclim Domain Entropy SVM. SVM . (SVM) 58 períodos XXI principalmente brasileira Sítios Ramsar protegêlas protegê las (Willd (SVM 5

Abstract Lipids are compounds that play an important role in coffee bean development, contributing to beverage quality. Genome-wide association studies (GWAS) were conducted to pinpoint quantitative trait nucleotides (QTNs) linked to lipid metabolism in Coffea arabica. Genotyping by sequencing (GBS) and phenotyping data from 104 wild C. arabica accessions, Mundo Novo cultivar, and C. arabica var. Typica were utilized. GBS data were aligned to C. arabica Et039 reference genome, and both single-locus and multi-locus GWAS methods were employed. Methods were adjusted for kinship matrix, population structure, and principal component analysis. Of the 19 QTNs identified, 5 showed consistency across different population structure adjustments. The multi-locus methods mrMLM and FarmCPU proved more effective in identifying QTNs associated with lipid content. Four QTNs were situated near seven genes potentially involved in lipid metabolism. Higher frequencies of identified QTNs in accessions with elevated lipid content suggest their utility as markers for coffee plant breeding. development quality Genomewide Genome wide (GWAS (QTNs (GBS 10 C cultivar var utilized Et Et03 genome singlelocus single locus multilocus multi employed matrix analysis 1 adjustments breeding Et0

Abstract This article aims to describe theoretical and methodological aspects of research on the concept of function in teaching training education based on a systematic literature review. The systematic review was conducted according to the principles of the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA), culminating in the categorization of the reviewed articles in order to identify the formative contexts for a reflection on the theoretical approaches and methodological strategies used in surveys. The results, communicated in a meta-synthesis and condensed in a table, point to theoretical-methodological directions of formative moments on the concept of function, evidencing the need to master the didactic-pedagogical resources to be used, to coordinate the knowledge transition process from arithmetic to algebraic and managing assessment and training processes, highlighting professional learning opportunities. MetaAnalyses Meta Analyses PRISMA, PRISMA , (PRISMA) surveys results metasynthesis meta synthesis table theoreticalmethodological didacticpedagogical didactic pedagogical processes opportunities (PRISMA

Resumo Este artigo visa descrever aspectos teóricos e metodológicos de pesquisas sobre o conceito de função na formação continuada, a partir da realização de uma revisão sistemática da literatura. A revisão sistemática foi realizada, segundo os princípios do Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA), e os artigos revisados foram categorizados, a fim de identificar os contextos formativos para uma reflexão sobre as abordagens teóricas e as estratégias metodológicas utilizadas nas pesquisas. Os resultados, comunicados em uma metassíntese e condensados em um quadro, apontam direcionamentos teórico-metodológicos de momentos formativos centrados no estudo do conceito de função e evidenciam a necessidade de dominar os recursos didático-pedagógicos a serem utilizados, de coordenar o processo de transição do conhecimento aritmético para o algébrico e de gerenciar os processos de avaliação e formação, destacando oportunidades de aprendizagem profissional. continuada literatura realizada MetaAnalyses Meta Analyses PRISMA, PRISMA , (PRISMA) categorizados resultados quadro teóricometodológicos teórico didáticopedagógicos didático pedagógicos utilizados profissional (PRISMA