The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stands for being the most serious epidemic (so far) of the 21st century. However, only a few computational studies have investigated the molecular mechanisms underlying the neutralization of the spike protein by antibodies of different classes. Hence, bioinformatic methods were employed to unravel the factors contributing to the remarkable neutralization capacity exhibited by specific antibodies. Initially, crystallographic structures of IgA monomeric / dimeric, IgG, and IgM antibodies binding with the receptor-binding domain region of the SARS-CoV-2 spike protein were retrieved. Subsequently, rigid molecular docking and molecular dynamic simulations were performed over 100 ns with explicit water solvation. Lastly, an energy decomposition was conducted to estimate the binding affinity using the last frames from molecular dynamics. The results revealed a higher binding affinity for both monomeric and dimeric forms of IgA antibodies against the spike protein. Additionally, a greater number of hydrogen bonds were observed during their interaction with the spike protein, as well as greater structural instability along the time and especially a more thermodynamically favorable interaction affinity. In this way, the research contributes a small piece to the complex puzzle of understanding the humoral immune response induced by the SARS-CoV-2 virus. SARSCoV2 SARSCoV SARS CoV (SARS-CoV-2 so far st century However classes Hence Initially IgG receptorbinding receptor SARS-CoV- retrieved Subsequently 10 solvation Lastly dynamics Additionally way virus (SARS-CoV- SARS-CoV 1 (SARS-CoV

ABSTRACT Purpose: Although Brazil has a high prevalence of retinoblastoma, there is a lack of epidemiological data on the disease. Thus, in this study, we aimed to evaluate the epidemiological profile of patients diagnosed with retinoblastoma in the ophthalmology department of a pediatric tertiary referral hospital in Ceara, Brazil. Methods: A descriptive and cross-sectional study was conducted by retrospectively analyzing the clinical and socioeconomic data from the medical records of pediatric patients followed-up at the hospital between 2007 and 2021. Retinoblastoma was diagnosed on the basis of a fundoscopic or histopathologic examination. Results: The data of 105 patients were included in the study, and the mean patient age at the time of diagnosis was 1.7 years. Most of the patients were women (50.5%) and hailed from rural areas (57.4%), which was associated with a higher tumor stage. Of the 150 patients, 57.1% initially presented with leukocoria. Ocular hyperemia was associated with more advanced stages of retinoblastoma (p=0.004). Bilateral involvement was observed in 25.7% of the patients and at a significantly younger age (p=0.009). The presence of retinal detachment, vascularized lesions, and vitreous seeds significantly increased the likelihood of requiring enucleation. Discussion: This study presents an epidemiological description of retinoblastoma in Brazil, which highlights the significance of early detection. Delayed diagnosis is associated with a poorer visual prognosis and higher mortality rate, particularly in patients with unilateral disease. Risk factors for a more severe disease were retinal detachment, vascularized lesions, and vitreous seeds. The correlation between histopathological features and clinical outcomes was limited. Conclusion: Further studies are required to assess the influence of ocular hyperemia, fundoscopic assessment, and histopathologic findings on the prognosis of retinoblastoma. Moreover, it is critical to devise interventions to reduce the time-to-diagnosis in rural areas. Purpose Thus Ceara Methods crosssectional cross sectional followedup followed up 200 2021 examination Results 10 17 1 7 1. years 50.5% 505 50 5 (50.5% 57.4%, 574 57.4% , 57 4 (57.4%) stage 15 571 57.1 leukocoria p=0.004. p0004 p p=0.004 . 0 004 (p=0.004) 257 25 25.7 p=0.009. p0009 p=0.009 009 (p=0.009) detachment lesions enucleation Discussion detection rate limited Conclusion assessment Moreover timetodiagnosis 20 202 50.5 (50.5 57.4 (57.4% 57. p000 p=0.00 00 (p=0.004 2 25. (p=0.009 50. (50. (57.4 p00 p=0.0 (p=0.00 (50 (57. p0 p=0. (p=0.0 (5 (57 p=0 (p=0. ( p= (p=0 (p= (p

Resumo: Chatbots podem utilizar-se de interações rápidas, e por vezes, especializada em diferentes situações, tornando-os uma opção na escolha de ferramentas para coletar informações. Na avaliação psicológica de crianças e adolescentes, podem atuar como fontes complementares, e auxiliar a descrever, qualificar e mensurar características psicológicas e comportamentais, nas suas diversas formas de expressão, em diferentes contextos. Este estudo objetivou apresentar o Psico Bot, um chatbot desenvolvido para avaliar sintomas de ansiedade e depressão em crianças e adolescentes. Composto por 20 questões que mapeiam sintomas físicos e psicológicos dos constructos selecionados, sendo desenvolvido por meio da linguagem natural Dialogflow para uso na plataforma de conversação Google Assistente, o design do Psico Bot pauta-se em representação neutra, sem sexo ou idade determinados, facilitando a rápida identificação do usuário. Respaldando-se na utilização de multimétodos avaliativos, o Psico Bot pode oferecer informações relevantes sobre a saúde mental de crianças e adolescentes utilizando linguagem e dispositivos de fácil compreensão e manuseio por essa população. Para o avaliador, a ferramenta oferece resposta rápida e informações específicas sobre cada constructo, possibilitando intervenções mais efetivas em elementos de maior necessidade.

Abstract: Chatbots can use fast, and sometimes specialized interactions in different situations, making them an option in the choice of tools to collect information. In the psychological assessment of children and adolescents, they can act as complementary sources, and help to describe, qualify and measure psychological and behavioral characteristics, in its various forms of expression, in different contexts. This study aimed to present Psico Bot, a chatbot developed to assess symptoms of anxiety and depression in children and adolescents. Consisting of 20 questions that map physical and psychological symptoms of the selected constructs, it was developed through the natural language Dialogflow for use in the Google Assistant conversation platform. The design of Psico Bot is based on a neutral representation, with no determined gender or age, facilitating quick identification by the user. Based on the use of multimethod evaluations, the Psico Bot can offer relevant information about the mental health of children and adolescents using language and devices that are easy to understand and handle by this population. For the evaluator, the tool offers quick response and specific information about each construct, enabling more effective interventions in elements of greatest need.

Resumen: Los chatbots pueden utilizar interacciones rápidas y, a veces especializadas, en diferentes situaciones, lo que los convierte en una opción en la elección de herramientas para recopilar información. En la evaluación psicológica de niños y adolescentes pueden actuar como fuentes complementarias y ayudar a describir, calificar y medir las características psicológicas y de comportamiento en sus diversas formas de expresión en diferentes contextos. Este estudio tuvo como objetivo presentar Psico Bot, un chatbot desarrollado para evaluar síntomas de ansiedad y depresión en niños y adolescentes. Compuesto por 20 preguntas que mapean síntomas físicos y psicológicos de los constructos seleccionados, fue desarrollado mediante el lenguaje natural Dialogflow para su uso en la plataforma de conversación Google Assistant. El diseño de Psico Bot se basa en una representación neutra, sin género ni edad determinados, lo que facilita la rápida identificación por parte del usuario. A partir del uso de evaluaciones multimétodo, Psico Bot puede ofrecer información relevante sobre la salud mental de niños y adolescentes utilizando un lenguaje y dispositivos de fácil comprensión y manejo para esta población. Para el evaluador, la herramienta ofrece una respuesta rápida e información específica sobre cada constructo, lo que permite intervenciones más eficaces en los elementos de mayor necesidad.

ABSTRACT The interaction between bean (Phaseolus vulgaris L.) genotypes and N-fixing microorganisms has the potential to be utilized in sustainable agricultural production. Thus, the aim of this study was to verify the effects of the interaction for growth, production and nodulation characteristics between the bacteria Rhizobium tropici and Azospirillum brasilense among different bean genotypes. The experiments were conducted in the Selvíria, Mato Grosso do Sul, Brazil, in 2018 and 2019, in randomized block design with three replicates in a 20 × 3 factorial scheme; 20 common bean genotypes were tested under three forms of inoculation (no inoculation, inoculation with R. tropici, co-inoculation of R. tropici + A. brasilense). The number of grains per pod and nodule mass had the most significant direct positive effect on grain yield. For nodulation, a positive correlation of strong magnitude was observed between mass of the aerial part and number of pods per plant (0.68), stem diameter and mass of nodules (0.92) and first pod insertion height and number of nodules (0.64). In the path analysis, the number of grains per pod had the most significant direct effect (0.57) on the grain productivity variable. Regarding nodulation characteristics, selection for nodule mass was preferred due to its direct effect on grain yield as opposed to the number of nodules, which has a negative effect. This suggests an advantage of larger nodules with greater individual mass than a large number of small nodules for both improved yield and N fixing by common bean plants.

RESUMO O desastre-crime do petróleo em 2019 é tido como o maior desastre ocorrido no litoral do Brasil. Considerada a primeira linha de enfrentamento de desastres no território, a gestão municipal de saúde é fundamental no processo de gestão de risco de desastre. Objetivou-se analisar a atuação de uma secretaria municipal de saúde da região metropolitana do Recife, Pernambuco, em relação ao derramamento do petróleo ocorrido em 2019. Foi realizado um estudo de caso do tipo descritivo com abordagem qualitativa. Foi realizada Análise de Conteúdo, com utilização do software IRaMuTeQ, das entrevistas com gestores da saúde, cujos resultados revelaram quatro categorias: gestão municipal na atenção com o mar; governança de risco de desastre e suas ausências; sindemia da covid-19 e impactos na reabilitação e recuperação das comunidades afetadas pelo desastre do petróleo; o que fazer se um desastre voltar a acontecer. No município em análise, houve a organização antecipada das ações de enfrentamento, a ausência da governança no desastre-crime e o enfoque da gestão em saúde na sindemia da covid-19, que foram apontados como dificuldades e vulnerabilidades na atuação, enquanto a educação permanente e a articulação com pescadores(as) e marisqueiras foram algumas das lições aprendidas. desastrecrime crime 201 Brasil território Objetivouse Objetivou Recife Pernambuco qualitativa Conteúdo IRaMuTeQ categorias mar ausências covid19 covid 19 covid-1 acontecer análise covid19, 19, pescadoresas pescadores as pescadores(as aprendidas 20 covid1 1 covid- 2

ABSTRACT The 2019 oil disaster-crime is considered the largest disaster on the Brazilian coast. Given the frontline in disaster response, the municipal health secretariat is crucial in the disaster risk management process. This study aimed to analyze the performance of a municipal health secretariat in the metropolitan region of Recife, Pernambuco, regarding the 2019 oil spill, adopting a descriptive, qualitative case study. We performed content Analysis with the IRaMuTeQ software on interviews with health managers, and the results revealed four categories: municipal management in marine care; disaster risk governance and its absence; the COVID-19 syndemic and its impacts on the rehabilitation and recovery of oil disaster-affected communities; what to do if a disaster strikes again. In the municipality under study, we noted early organization of response actions, the lack of governance in the disaster-crime, and health management focus on COVID-19 syndemic, which were identified as difficulties and vulnerabilities in their actions, while continuing education and coordination with fishermen and shellfish gatherers were among the lessons learned. 201 disastercrime crime coast process Recife Pernambuco spill descriptive managers categories care absence COVID19 COVID 19 COVID-1 disasteraffected affected communities again actions disastercrime, crime, learned 20 COVID1 1 COVID- 2

Abstract This integrative review aims to identify the mental health care measures that were produced during the COVID-19 pandemic. This research was conducted on three databases (SciELO, PubMed, and LILACS) with the following descriptors in Portuguese, English, and Spanish: “SAÚDE MENTAL” or “SALUD MENTAL” or “MENTAL HEALTH” AND “COVID-19” from 2020 to 2021. In total, 3,451 articles were found, 43 of which were analyzed. Most measures were digital, stemmed from public institutions, focused on the local perspective, and were integrated with the public health care system. This study discusses the models of care in mental health based on measures to cope with the COVID-19 pandemic. It also discusses the Brazilian health care system, reiterating its resilience. In conclusion, digital measures occurred most often. This study suggest the evaluation of the accessibility of this mental health care model for most vulnerable groups. Finally, this research reinforces the importance of the Brazilian health care system for public health and access to information to cope with the COVID-19 pandemic. COVID19 COVID 19 COVID-1 pandemic SciELO, SciELO (SciELO PubMed LILACS Portuguese English Spanish SAÚDE MENTAL SALUD HEALTH “COVID-19 202 2021 total 3451 3 451 3,45 found 4 analyzed institutions perspective resilience conclusion often groups Finally COVID1 1 COVID- “COVID-1 20 345 45 3,4 “COVID- 2 34 3, “COVID

Resumo A presente revisão integrativa tem por objetivo identificar os arranjos de cuidado em saúde mental que foram implementados no enfrentamento à pandemia de COVID-19. Realizou-se busca em três bases de dados (SciELO, PubMed e LILACS), em português, inglês e espanhol, com os descritores “SAÚDE MENTAL” or “SALUD MENTAL” or “MENTAL HEALTH” AND “COVID-19”, no período de 2020 a 2021. Foram encontrados 3.451 artigos, sendo 43 selecionados para análise. Em relação ao cuidado em saúde mental, os principais arranjos identificados foram os digitais, de natureza pública, desenvolvidos na esfera municipal e com integração com a rede de saúde. Os modelos de cuidado em saúde mental para o enfrentamento da pandemia são discutidos a partir dos tipos de arranjo produzidos nesse contexto sanitário emergencial e crítico. Apresenta-se, ainda, um recorte da realidade encontrada no Sistema Único de Saúde (SUS), reiterando sua resiliência. Concluiu-se que os arranjos digitais foram os mais usados e que há necessidade de investigar a acessibilidade deste modelo para populações com maior vulnerabilidade social. Reafirma-se a importância do SUS para o enfrentamento da COVID-19 e no acesso a informações de saúde. COVID19. COVID19 COVID 19. 19 Realizouse Realizou se SciELO, SciELO (SciELO LILACS, LILACS , LILACS) português espanhol SAÚDE MENTAL SALUD HEALTH COVID19, “COVID-19” 202 2021 3451 3 451 3.45 artigos 4 análise pública crítico Apresentase, Apresentase Apresenta se, Apresenta-se ainda SUS, (SUS) resiliência Concluiuse Concluiu social Reafirmase Reafirma COVID-1 COVID1 1 “COVID-19 20 345 45 3.4 (SUS COVID- “COVID-1 2 34 3. “COVID- “COVID

Abstract Primary Health Care (PHC) proved to be an important part of the prevention, control and treatment measures against COVID-19, a situation in which it was challenged to keep up its provision of regular services as well. This article identifies the main arrangements made to provide PHC care in the context of the COVID-19 pandemic. An integrative literature review of articles found in PubMed, SciELO and LILACS databases was performed using the descriptors “Primary Health Care” and “COVID-19”. Findings were analyzed considering three questions: Information and Communication Technologies (ICT), Organizations of Work Processes and Non-COVID Chronic Diseases. The use of different forms of ICT to provide PHC is highlighted regarding patients with respiratory symptoms and chronic patients. Changes in team composition, service flows, physical spaces and working hours were also introduced. Although strategies aimed at monitoring chronic patients and at remote care may have helped minimize deterioration of their health, the decrease in the number of visits performed during this period could have resulted in an increased demand for PHC in post-pandemic years. (PHC prevention COVID19, COVID19 COVID 19, 19 well COVID-1 pandemic PubMed COVID19. . “COVID-19” questions ICT, , (ICT) NonCOVID Non Diseases composition flows introduced health postpandemic post years COVID1 1 COVID- “COVID-19 (ICT “COVID-1 “COVID- “COVID

Resumo A Atenção Primária à Saúde (APS) demonstrou ser parte importante das medidas de prevenção, controle e tratamento do COVID-19, ao mesmo tempo em que foi desafiada a manter a oferta dos serviços regulares. O objetivo deste artigo é identificar os principais arranjos desenvolvidos para ofertar cuidados na APS na pandemia do COVID-19. A revisão integrativa foi realizada nas bases de dados PubMed, SciELO e LILACS por meio dos descritores “Atenção Primária à Saúde” e “COVID-19”. Os resultados foram analisados por meio de três questões: Tecnologias de Informação e Comunicação (TIC), Organizações dos Processos de Trabalho e Doenças Crônicas Não-COVID. Ganha grande destaque o uso das TIC no cuidado ofertado na APS, tanto para pacientes com sintomas respiratórios quanto para pacientes crônicos. Alterações na composição das equipes, fluxos de atendimento, espaços físicos e horários de atendimento também foram implantadas. Ainda que estratégias que visaram o monitoramento dos pacientes crônicos e o atendimento remoto podem ter contribuído para minimizar os agravos à saúde desses usuários, a diminuição dos atendimentos realizados neste período poderá resultar em uma grande demanda para a APS nos anos pós-pandemia. (APS prevenção COVID19, COVID19 COVID 19, 19 COVID-19 regulares COVID19. 19. PubMed . “COVID-19” questões TIC, , (TIC) NãoCOVID. NãoCOVID Não COVID. Não-COVID equipes implantadas usuários póspandemia. póspandemia pós pandemia. pós-pandemia COVID1 1 COVID-1 “COVID-19 (TIC COVID- “COVID-1 “COVID- “COVID

Resumo A Atenção Primária à Saúde (APS) demonstrou ser parte importante das medidas de prevenção, controle e tratamento do COVID-19, ao mesmo tempo em que foi desafiada a manter a oferta dos serviços regulares. O objetivo deste artigo é identificar os principais arranjos desenvolvidos para ofertar cuidados na APS na pandemia do COVID-19. A revisão integrativa foi realizada nas bases de dados PubMed, SciELO e LILACS por meio dos descritores “Atenção Primária à Saúde” e “COVID-19”. Os resultados foram analisados por meio de três questões: Tecnologias de Informação e Comunicação (TIC), Organizações dos Processos de Trabalho e Doenças Crônicas Não-COVID. Ganha grande destaque o uso das TIC no cuidado ofertado na APS, tanto para pacientes com sintomas respiratórios quanto para pacientes crônicos. Alterações na composição das equipes, fluxos de atendimento, espaços físicos e horários de atendimento também foram implantadas. Ainda que estratégias que visaram o monitoramento dos pacientes crônicos e o atendimento remoto podem ter contribuído para minimizar os agravos à saúde desses usuários, a diminuição dos atendimentos realizados neste período poderá resultar em uma grande demanda para a APS nos anos pós-pandemia.

Abstract Primary Health Care (PHC) proved to be an important part of the prevention, control and treatment measures against COVID-19, a situation in which it was challenged to keep up its provision of regular services as well. This article identifies the main arrangements made to provide PHC care in the context of the COVID-19 pandemic. An integrative literature review of articles found in PubMed, SciELO and LILACS databases was performed using the descriptors “Primary Health Care” and “COVID-19”. Findings were analyzed considering three questions: Information and Communication Technologies (ICT), Organizations of Work Processes and Non-COVID Chronic Diseases. The use of different forms of ICT to provide PHC is highlighted regarding patients with respiratory symptoms and chronic patients. Changes in team composition, service flows, physical spaces and working hours were also introduced. Although strategies aimed at monitoring chronic patients and at remote care may have helped minimize deterioration of their health, the decrease in the number of visits performed during this period could have resulted in an increased demand for PHC in post-pandemic years.

Resumo Objetivou-se refletir sobre o impacto do racismo estrutural na saúde dos adolescentes afrodescendentes brasileiros, considerando o contexto político e social do período pós-abolição, quando foi iniciada uma nova configuração de exploração e manutenção das desigualdades sociais relacionadas aos escravizados libertos e seus descendentes. É na adolescência, fase da vida ligada ao contexto social e cultural, e não apenas determinada pelo período cronológico da vida, quando geralmente o indivíduo negro começa a vivenciar de modo mais consciente o estigma da raça. Este ensaio, inicialmente, apresenta o percurso histórico da construção social da raça nos padrões de dominação e o racismo. Em seguida, reflete, balizado no racismo estrutural, sobre o papel do capitalismo monopolista no desenvolvimento e crescimento econômico do Brasil pós-abolicionista, como um dos principais mecanismos de recrutamento e manutenção da população negra nas classes sociais inferiores e marginalizadas. Por fim, discute como o racismo impacta a saúde dos adolescentes afrodescendentes brasileiros a partir da teoria ecossocial, proposta por Nancy Krieger, e de bibliografia representativa. O racismo estrutural em nossa sociedade impacta na saúde dos adolescentes negros, com forte determinação no processo de saúde-doença. Por isso, é preciso combater as disparidades históricas, no sentido de se construir uma sociedade mais democrática e igualitária. Objetivouse Objetivou pósabolição, pósabolição pós abolição, abolição pós-abolição descendentes adolescência cultural ensaio inicialmente seguida reflete pósabolicionista, pósabolicionista abolicionista, abolicionista pós-abolicionista marginalizadas fim ecossocial Krieger representativa negros saúdedoença. saúdedoença doença. doença saúde-doença isso históricas igualitária

Abstract The objective was to reflect on the impact of structural racism on the health of Brazilian Afro-descendant adolescents, considering the political and social context of the post-abolition period, when a new configuration of exploitation and maintenance of social inequalities related to freed slaves and their descendants began. It is during adolescence, a phase of life linked to the social and cultural context, and not just determined by the chronological period of life, when black individuals generally begin to experience the stigma of race more consciously. This essay initially presents the historical path of the social construction of race in patterns of domination and racism. It then reflects, based on structural racism, on the role of monopoly capitalism in the development and economic growth of post-abolitionist Brazil, as one of the main mechanisms for recruiting and maintaining the black population in lower and marginalized social classes. Finally, it discusses how racism impacts the health of Brazilian Afro-descendant adolescents based on the ecosocial theory, proposed by Nancy Krieger, and representative bibliography. Structural racism in our society impacts the health of black adolescents, with a strong determination in the health-disease process; Therefore, it is necessary to combat historical disparities, to build a more democratic and egalitarian society. Afrodescendant Afro descendant postabolition post abolition began adolescence consciously reflects postabolitionist abolitionist Brazil classes Finally theory Krieger bibliography healthdisease disease process Therefore disparities

Resumen Objetivo Comprender la percepción del acceso y de la calidad de la alimentación según personas en situación de calle. Métodos Estudio descriptivo cualitativo, realizado en un Centro de Referencia de Personas de la Calle en la región centro-sur de Belo Horizonte (Minas Gerais). Se utilizó un guion semiestructurado para realizar entrevistas a 18 participantes. La recopilación de datos se realizó entre diciembre de 2020 y enero de 2021. El análisis temático del material, propuesto por Bardin, permitió la elaboración de tres categorías empíricas. Resultados El público entrevistado era masculino, de 43 años de edad promedio y tiempo promedio de situación de calle de 44,6 meses. El acceso a la alimentación fue proveniente de donaciones de alimentos, comidas en instituciones gubernamentales y adquisiciones al disponer de ingresos. Las personas relataron dificultades con relación a la cantidad y calidad de los alimentos, a la adquisición de comida los fines de semana, a los sentimientos de miedo y angustia ante el hambre, a la falta de alimentos y al estigma social, agravados por el COVID-19. Conclusión Ante el escenario de iniquidades sociales, el derecho al acceso a la alimentación no está garantizado, por lo cual es necesario implementar políticas públicas de protección social que garanticen los derechos básicos. cualitativo centrosur centro sur Minas Gerais. Gerais . Gerais) 1 participantes 202 2021 material Bardin empíricas masculino 4 446 44 6 44, meses ingresos semana hambre COVID19. COVID19 COVID 19. 19 COVID-19 sociales garantizado básicos 20 COVID1 COVID-1 2 COVID-

Abstract Objective To understand the perception of access to food and food quality for the street population. Methods This qualitative descriptive study was performed in a Reference Center for the Homeless Population in the south-central region of Belo Horizonte (MG). A semi-structured script was used to conduct interviews with 18 participants. Data collection occurred between December 2020 and January 2021. The thematic analysis of the material, as proposed by Bardin, made it possible to elaborate three empirical categories. Results The public interviewed was male, with a mean age of 43 years, and a mean time on the streets of 44.6 months. Access to food came from donations, meals at government institutions, and acquisition when income was available. Difficulties were reported regarding the quantity and quality of food, acquisition of meals on weekends, feelings of fear and anguish in the face of hunger, lack of food, and social stigma, which were aggravated by COVID-19. Conclusion As in this scenario of social inequalities the access to food is not guaranteed, implementing public policies of social protection is necessary to guarantee basic rights. population southcentral south central MG. MG . (MG) semistructured semi structured 1 participants 202 2021 material Bardin categories male 4 years 446 44 6 44. months donations institutions available weekends hunger stigma COVID19. COVID19 COVID 19. 19 COVID-19 guaranteed rights (MG 20 COVID1 COVID-1 2 COVID-

Resumo Objetivo Compreender a percepção do acesso e da qualidade da alimentação para a população em situação de rua. Métodos Estudo descritivo qualitativo, realizado em um Centro de Referência da População de Rua na região centro-sul de Belo Horizonte (MG). Utilizou-se roteiro semiestruturado para a realização das entrevistas de 18 participantes. A coleta de dados ocorreu entre dezembro de 2020 e janeiro de 2021. A análise temática do material, proposta por Bardin, possibilitou a elaboração de três categorias empíricas. Resultados O público entrevistado era masculino, com idade média de 43 anos e tempo médio de situação de rua de 44,6 meses. O acesso à alimentação foi proveniente das doações de alimentos, refeições em instituições governamentais e aquisições ao dispor de renda. Foram relatadas dificuldades quanto à quantidade e qualidade dos alimentos, à aquisição das refeições nos fins de semana, aos sentimentos de medo e angústia perante a fome, à falta do alimento e pelo estigma social, agravados pela COVID-19. Conclusão Diante do cenário de iniquidades sociais, o direito ao acesso à alimentação não é garantido, sendo necessária a implementação de políticas públicas de proteção social que garantam os direitos básicos. qualitativo centrosul centro sul MG. MG . (MG) Utilizouse Utilizou se 1 participantes 202 2021 material Bardin empíricas masculino 4 446 44 6 44, meses alimentos renda semana fome COVID19. COVID19 COVID 19. 19 COVID-19 sociais garantido básicos (MG 20 COVID1 COVID-1 2 COVID-

Objective: To ascertain whether sociodemographic and health-related characteristics known from previous research to have a substantive impact on recovery from depression modified the effect of a digital intervention designed to improve depressive symptoms (CONEMO). Methods: The CONEMO study consisted of two randomized controlled trials, one conducted in Lima, Peru, and one in São Paulo, Brazil. As a secondary trial plan analysis, mixed logistic regression was used to explore interactions between the treatment arm and subgroups of interest defined by characteristics measured before randomization – suicidal ideation, race/color, age, gender, income, type of mobile phone, alcohol misuse, tobacco use, and diabetes/hypertension – in both trials. We estimated interaction effects between the treatment group and these subgroup factors for the secondary outcomes using linear mixed regression models. Results: Increased effects of the CONEMO intervention on the primary outcome (reduction of at least 50% in depressive symptom scores at 3-month follow-up) were observed among older and wealthier participants in the Lima trial (p = 0.030 and p = 0.001, respectively). Conclusion: There was no evidence of such differential effects in São Paulo, and no evidence of impact of any other secondary outcomes in either trial. Clinical trial registration: NCT02846662 (São Paulo, Brazil – SP), NCT03026426 (Lima, Peru – LI). Funded by the U.S. National Institute of Mental Health (grant U19MH098780). Objective healthrelated health related CONEMO. . (CONEMO) Methods trials Paulo analysis ideation racecolor race color race/color age gender income phone misuse use diabeteshypertension diabetes hypertension models Results reduction 50 3month month 3 followup follow up follow-up 0030 0 030 0.03 0001 001 0.001 respectively. respectively respectively) Conclusion registration NCT NCT0284666 SP, SP , SP) NCT0302642 (Lima LI. LI LI) US U S U.S grant U19MH098780. U19MH098780 UMH MH U19MH098780) (CONEMO 5 003 03 0.0 000 00 0.00 NCT028466 NCT030264 U19MH09878 0. NCT02846 NCT03026 U19MH0987 NCT0284 NCT0302 U19MH098 NCT028 NCT030 U19MH09 NCT02 NCT03 U19MH0 NCT0 U19MH

ABSTRACT Land sharing (Lsh) and land sparing (Lsp) are land use strategies that present different potentials for achieving multiple objectives in the land use planning, such as biodiversity conservation and provision of ecosystem services. Through a case study in the Saltinho Watershed in Imbaú/PR, we evaluated the extent to which the application of each of these strategies in landscape planning can contribute to the conservation of biodiversity and maintenance of water quality. The analysis was performed based on the comparison between three scenarios: native vegetation cover in 2008, compliance with the law nº. 12,651/12 and watershed-scale vegetation planning, in accordance with the precepts of the Lsh and Lsp. For each scenario, landscape metrics and sediment production were calculated, using a vector-based analysis tool (V-LATE) and an ecosystem service management tool (InVEST). In the studied models, the results indicate that the application of Lsh and Lsp contributed to the improvement of landscape metrics and to the reduction of the quantity of sediments exported to water courses, which could represent positive effects for biodiversity and water quality in the watershed. However, these effects were not directly proportional, according to the transition of the analyzed scenarios. Therefore, the exploration of different land use configurations and proportions between these strategies can contribute to identify potential thresholds for biodiversity conservation and provision of ecosystem services, and, in addition, assist in land use planning for sustainable agricultural landscapes. (Lsh (Lsp services ImbaúPR Imbaú PR Imbaú/PR scenarios 2008 nº 1265112 12 651 12,651/1 watershedscale watershed scale scenario calculated vectorbased vector VLATE V LATE (V-LATE InVEST. InVEST . (InVEST) models courses However proportional Therefore addition landscapes 200 126511 1 65 12,651/ (InVEST 20 12651 6 12,651 2 1265 12,65 126 12,6 12,

RESUMO Land sharing (Lsh) e land sparing (Lsp) são estratégias de uso do solo que apresentam diferentes potenciais para o alcance de múltiplos objetivos no processo de planejamento da paisagem, como a conservação da biodiversidade e a provisão de serviços ecossistêmicos. Por meio da realização de um estudo de caso na bacia hidrográfica do rio Saltinho em Imbaú/PR, buscou-se avaliar em que medida a aplicação dessas estratégias contribui para a conservação da biodiversidade e a manutenção da qualidade da água na bacia. A análise foi realizada a partir da comparação entre três cenários: cobertura de vegetação nativa em 2008, conformidade com a Lei n.º 12.651/12 e planejamento da vegetação na escala da bacia, de acordo com os preceitos do Lsh e do Lsp. Para cada cenário, foram calculadas as métricas de paisagem e a produção de sedimentos, com o uso de uma ferramenta de análise baseada em vetores (V-LATE) e uma ferramenta de gestão de serviços ecossistêmicos (InVEST). Nos modelos estudados, os resultados indicam que a aplicação do Lsh e Lsp contribuiu para a melhoria de métricas de paisagem e para a redução da quantidade de sedimentos exportados aos corpos hídricos, o que poderia representar efeitos positivos para a biodiversidade e qualidade da água na bacia. No entanto, esses efeitos não se mostraram diretamente proporcionais, conforme transição dos cenários analisados. Dessa forma, a exploração de diferentes configurações e proporções de usos do solo entre essas estratégias pode auxiliar a identificação de potenciais limiares para conservação da biodiversidade e provisão de serviços ecossistêmicos, e, além disso, no planejamento de paisagens agrícolas sustentáveis. (Lsh (Lsp ImbaúPR Imbaú PR Imbaú/PR buscouse buscou 2008 nº n º 1265112 12 651 12.651/1 cenário VLATE V LATE (V-LATE InVEST. InVEST . (InVEST) estudados hídricos entanto proporcionais analisados forma disso sustentáveis 200 126511 1 65 12.651/ (InVEST 20 12651 6 12.651 2 1265 12.65 126 12.6 12.

Abstract Objectives Olfactory loss is a recognized long-term dysfunction after Coronavirus Disease 2019 (COVID-19) infection. This investigation aimed to assess the effect of alpha-lipoic acid as an adjuvant treatment of olfactory training on the improvement of smell loss in post-COVID-19 patients. Methods This randomized controlled trial included 128 adult outpatients who had persistent smell loss for more than 3-months after COVID-19 infection. The participants were randomly allocated into two groups: the intervention treatment group, which received alpha-lipoic acid associated to olfactory training, and comparison treatment group, which received placebo pills associated to olfactory training. The participants were followed-up for 12-weeks. Olfactory dysfunction was assessed in terms of Visual Analog Scale (VAS), and the Connecticut Chemosensory Clinical Research Center (CCCRC) test for the Brazilian population. Results A total of 100 participants completed the follow-up period and were analyzed in this study. Both groups have improved CCCRC score (p= 0.000), olfactory threshold (p= 0.000), identification score (p= 0.000) and VAS score (p= 0.000) after 12-weeks follow-up. No significant differences were determined between the intervention and comparison treatment groups in CCCRC score (p= 0.63), olfactory threshold (p= 0.50), identification score (p= 0.96) and VAS score (p= 0.97). In all these criteria, comparison treatment group went slightly worse. At the endpoint of the study, the frequency of anosmia reduced to 2% in the intervention treatment group and to 7.8% in the comparison treatment group. Also, 16.8% of the intervention group’ subjects, and 15.7% of comparison treatment group’s patients reached normosmia. Conclusions Overall, there was a strongly significant difference in olfactory function between baseline and endpoint for both groups. However, based on the lack of significant difference between the intervention treatment and the comparison treatment groups in terms of olfactory changes, our study appoints that the alpha-lipoic acid is not better than olfactory training alone to treat olfactory loss after COVID-19. Level of evidence Level 2. longterm long term 201 COVID19 COVID 19 (COVID-19 infection alphalipoic alpha lipoic postCOVID19 postCOVID post post-COVID-1 12 3months months 3 COVID-1 followedup followed up 12weeks. 12weeks weeks weeks. VAS, , (VAS) (CCCRC population 10 followup follow p= p (p 0.000, 0000 0.000 0 000 followup. up. 0.63, 063 0.63 63 0.63) 0.50, 050 0.50 50 0.50) 0.96 096 96 0.97. 097 0.97 . 97 0.97) criteria worse 2 78 7 8 7.8 Also 168 16 16.8 subjects 157 15 15.7 s normosmia Overall However changes COVID19. 19. 20 COVID1 1 (COVID-1 postCOVID1 post-COVID- COVID- (VAS 0.00 00 06 0.6 6 05 0.5 5 0.9 09 9 7. 16. 15. (COVID- post-COVID 0.0 0. (COVID

ABSTRACT: Wischnewsky spots (WS) are hemorrhagic, non-erosive, and non-ulcerative lesions that affect the gastric mucosa. They are considered common in the stomachs of humans who have died from hypothermia and are rarely described in other animal species. This study describes the occurrence of WS in cattle that had died of hypothermia in two cities in the state of Mato Grosso do Sul. Two properties were visited, and three cattle were necropsied by the team from the Pathological Anatomy Laboratory of the Federal University of Mato Grosso do Sul (LAP-UFMS). The epidemiological conditions and clinical signs of the cattle examined on both properties were similar. The deaths occurred on days when there was a sudden drop in environmental temperature, with continuous rain for more than 24 hours. During the visits, the most affected live cattle were found in sternal decubitus, with their heads resting on their flanks, or laterally in a comatose state, with nystagmus and a rectal temperature below 32°C. Macroscopically, there were multifocal to coalescent red and black areas on the mucosal surface of the abomasums of the three cattle necropsied, mainly at the apex of the folds, oval or punctate in shape, measuring 0.1 to 1.0cm in diameter. Microscopically, these dark areas corresponded to areas of rarefaction of the mucosal epithelial cells associated with hemorrhage and the frequent deposition of golden-brown pigment (hematin) in the extracellular medium. The diagnosis of hypothermia in cattle was based on epidemiology, clinical-pathological examination, and the exclusion of differential diagnoses. The lesions found in the abomasum of cattle that had died from hypothermia were compatible with WS, highlighting the importance of recognizing them in cases of cattle deaths in which this condition is suspected. ABSTRACT (WS hemorrhagic nonerosive, nonerosive non erosive, erosive non-erosive nonulcerative ulcerative mucosa species visited LAPUFMS. LAPUFMS LAP UFMS . (LAP-UFMS) similar 2 hours visits decubitus flanks 32C C 32 32°C Macroscopically folds shape 01 0 1 0. 10cm cm 0cm diameter Microscopically goldenbrown golden brown hematin (hematin medium epidemiology clinicalpathological pathological examination diagnoses suspected (LAP-UFMS 3

RESUMO: As manchas de Wischnewsky (WS) são lesões hemorrágicas, não erosivas e não ulcerativas que acometem a mucosa gástrica. Eles são considerados comuns no estômago de humanos que morreram de hipotermia e raramente são descritos em outras espécies animais. Este estudo descreve a ocorrência de WS em bovinos que morreram por hipotermia em duas cidades do estado de Mato Grosso do Sul. Duas propriedades foram visitadas e três bovinos foram necropsiados pela equipe do Laboratório de Anatomia Patológica da Universidade Federal de Mato Grosso do Sul (LAP-UFMS). As condições epidemiológicas e os sinais clínicos dos bovinos examinados nas duas propriedades foram semelhantes. As mortes ocorreram em dias em que houve queda brusca da temperatura ambiente, com chuva contínua por mais de 24 horas. Os bovinos vivos mais acometidos no momento das visitas foram encontrados em decúbito esternal, com a cabeça apoiada nos flancos, ou lateralmente em estado de coma, com nistagmo e temperatura retal abaixo de 32°C. Macroscopicamente, havia áreas vermelhas e pretas multifocais a coalescentes na superfície mucosa dos abomasos dos três bovinos necropsiados, principalmente no ápice das pregas, de formato oval ou pontiforme, medindo de 0,1 a 1,0cm de diâmetro. Microscopicamente, essas áreas escuras correspondiam a áreas de rarefação das células epiteliais da mucosa associadas à hemorragia e à frequente deposição de pigmento marrom-dourado (hematina) no meio extracelular. O diagnóstico de hipotermia em bovinos foi baseado na epidemiologia, no exame clínico-patológico e na exclusão de diagnósticos diferenciais. As lesões encontradas no abomaso de bovinos que morreram por hipotermia foram compatíveis com WS, destacando a importância de reconhecê-las em casos de mortes de bovinos em que haja suspeita desta condição. RESUMO (WS hemorrágicas gástrica animais LAPUFMS. LAPUFMS LAP UFMS . (LAP-UFMS) semelhantes ambiente 2 horas esternal flancos coma 32C C 32 32°C Macroscopicamente pregas pontiforme 01 0 1 0, 10cm cm 0cm diâmetro Microscopicamente marromdourado marrom dourado hematina (hematina extracelular epidemiologia clínicopatológico clínico patológico diferenciais reconhecêlas reconhecê las condição (LAP-UFMS 3