Pesquisa | SciELO

Objectives: To summarize evidence-based cognitive-behavioral therapy (CBT) treatment and propose clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The literature on CBT interventions for adult OCD, including BT and exposure and response prevention, was systematically reviewed to develop updated clinical guidelines for clinicians, providing comprehensive details about the necessary procedures for the CBT protocol. We searched the literature from 2013-2020 in five databases (PubMed, Cochrane, Embase, PsycINFO, and Lilacs) regarding study design, primary outcome measures, publication type, and language. Selected articles were assessed for quality with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association. Results: We examined 44 new studies used to update the 2013 American Psychiatric Association guidelines. High-quality evidence supports CBT with exposure and response prevention techniques as a first-line treatment for OCD. Protocols for Internet-delivered CBT have also proven efficacious for adults with OCD. Conclusion: High-quality scientific evidence supports the use of CBT with exposure and response prevention to treat adults with OCD.

https://doi.org/10.47626/1516-4446-2023-3081

Current clinical and research practices on frontotemporal dementia in Brazil: a national survey
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Souza, Leonardo Cruz de

; Brucki, Sonia Maria Dozzi

; Schilling, Lucas Porcello

; Silva, Letícia Costa da

; Takada, Leonel Tadao

; Bahia, Valéria Santoro

; Barbosa, Breno José Alencar Pires

; Balthazar, Marcio Luiz Figueredo

; Frota, Norberto Anizio Ferreira

; Nitrini, Ricardo

; Caramelli, Paulo

; Smid, Jerusa

Arquivos de Neuro-Psiquiatria

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Jul 2023, Volume 81 Nº 7 Páginas 632 - 640

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Background Frontotemporal dementia (FTD) is a frequent cause of young-onset dementia and represents a major challenge for the diagnosis and clinical management. It is essential to evaluate the difficulties faced by physicians on the diagnostic workup and on patient care. Objective The aim of this study was to investigate the current practices and the local limits on the diagnosis and management of FTD in Brazil. Methods We elaborated an online survey, composed of 29 questions and divided in four parts, comprising questions about existing health facilities, clinical practices related to FTD, and suggestions to increment the national research on FTD. The invitation to participate was sent by email to all neurologists affiliated to the Brazilian Academy of Neurology (n = 3658), and to all physicians who attended the XII Meeting of Researchers on Alzheimer's disease, in 2019 (n = 187). The invitation was also diffused through social media. Results 256 Brazilian physicians answered the questionnaire. The three most relevant disorders for the differential diagnosis of FTD were Alzheimer's disease (AD) (n = 211), bipolar disorder (n = 117) and dementia with Lewy bodies (n = 92). Most respondents (125/256) reported the difficulty in performing genetic testing as the main limit in the diagnostic of FTD. 93% and 63% of participants considered that the assessment of social cognition and AD CSF biomarkers are useful for the diagnosis of FTD, respectively. Conclusions The present study may provide valuable insights for the medical education and clinical training of physicians, and to foster future research on FTD in Brazil.

Resumo Antecedentes A demência frontotemporal (DFT) é causa frequente de demência pré-senil e representa um desafio em termos de diagnóstico e de manejo clínico. É essencial avaliar as dificuldades existentes na propedêutica e nos cuidados médicos. Objetivo Investigar as práticas médicas e as dificuldades para diagnóstico e manejo da DFT no Brasil. Métodos Elaborou-se um questionário online, composto de 29 questões, divididas em quatro partes, com perguntas sobre infraestrutura existente, práticas clínicas relacionadas à DFT e sugestões para desenvolver a pesquisa nacional na área. O convite para participação foi enviado por e-mail a todos neurologistas afiliados à Academia Brasileira de Neurologia (n = 3658), e aos médicos que participaram da XII Reunião de Pesquisadores de Doença de Alzheimer, em 2019 (n = 187). O convite também foi divulgado através de mídias sociais. Resultados 256 médicos brasileiros responderam o questionário. Os três principais diagnósticos diferenciais de DFT foram doença de Alzheimer (n = 211), transtorno bipolar (n = 117) e demência com corpos de Lewy (n = 92). A maior parte dos respondedores (125/256) apontou a dificuldade em realizar testagem genética como o maior limite no diagnóstico de DFT. 93% e 63% dos respondedores indicaram que a avaliação de cognição social e o uso de biomarcadores liquóricos de doença de Alzheimer são úteis no diagnóstico de DFT, respectivamente. Conclusões Estes resultados devem ser considerados na educação e treinamento médicos, e no desenvolvimento da pesquisa brasileira em DFT.

https://doi.org/10.1055/s-0043-1771173

Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders guidelines for the treatment of adult obsessive-compulsive disorder. Part I: pharmacological treatment
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de Oliveira, Marcos Vinícius Sousa

; de Barros, Pedro Macul Ferreira

; de Mathis, Maria Alice

; Boavista, Rodrigo

; Chacon, Priscila

; Echevarria, Marco Antonio Nocito

; Ferrão, Ygor Arzeno

; Vattimo, Edoardo Felippo de Queiroz

; Lopes, Antônio Carlos

; Torres, Albina Rodrigues

; Diniz, Juliana Belo

; Fontenelle, Leonardo F.

; Rosário, Maria Conceição do

; Shavitt, Roseli Gedanke

; Miguel, Eurípedes Constantino

; da Silva, Renata de Melo Felipe

; Costa, Daniel Lucas da Conceição

Brazilian Journal of Psychiatry

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Abr 2023, Volume 45 Nº 2 Páginas 146 - 161

Resumo: En | Texto: En | PDF: En

Objectives: To summarize evidence-based pharmacological treatments and provide guidance on clinical interventions for adult patients with obsessive-compulsive disorder (OCD). Methods: The American Psychiatric Association (APA) guidelines for the treatment of OCD (2013) were updated with a systematic review assessing the efficacy of pharmacological treatments for adult OCD, comprising monotherapy with selective serotonin reuptake inhibitors (SSRIs), clomipramine, serotonin and norepinephrine reuptake inhibitors (SNRIs), and augmentation strategies with clomipramine, antipsychotics, and glutamate-modulating agents. We searched for the literature published from 2013-2020 in five databases, considering the design of the study, primary outcome measures, types of publication, and language. Selected articles had their quality assessed with validated tools. Treatment recommendations were classified according to levels of evidence developed by the American College of Cardiology and the American Heart Association (ACC/AHA). Results: We examined 57 new studies to update the 2013 APA guidelines. High-quality evidence supports SSRIs for first-line pharmacological treatment of OCD. Moreover, augmentation of SSRIs with antipsychotics (risperidone, aripiprazole) is the most evidence-based pharmacological intervention for SSRI-resistant OCD. Conclusion: SSRIs, in the highest recommended or tolerable doses for 8-12 weeks, remain the first-line treatment for adult OCD. Optimal augmentation strategies for SSRI-resistant OCD include low doses of risperidone or aripiprazole. Pharmacological treatments considered ineffective or potentially harmful, such as monotherapy with antipsychotics or augmentation with ketamine, lamotrigine, or N-acetylcysteine, have also been detailed.

https://doi.org/10.47626/1516-4446-2022-2891

Influence of humus on chromium absorption by coffee seedlings grown on substrate containing tannery sludge
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Berilli, Sávio da Silva

; Oliveira, Dhiego da Silva

; Martineli, Leonardo

; Pereira, Lucas Louzada

; Cunha, Maura Da

; Pireda, Saulo

Revista Ceres

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Jan 2023, Volume 70 Nº 1 Páginas 87 - 97

Resumo: En | Texto: En | PDF: En

ABSTRACT Chromium is present in the tannery sludges worldwide making it a problem for agriculture. This study aimed to evaluate whether humus functions as a chromium stabilizing agent when using tannery sludge in the substrate of conilon coffee seedlings (Coffea canephora) and to determine what effects there are on leaf development and anatomy. Treatments consisted of a fixed dose of tannery sludge (30% of volume) on substrates of conilon coffee seedlings with different proportions of humus and subsoil (T-10, T-20, T-30, T-40% of humus). Information for the evaluation of leaf anatomy and seedling development was collected at 180 days after the planting of cuttings. From the phenological point of view, the treatments that best promoted seedling quality were T-30 and T-40. However, the greater the amount of humus in the substrate the greater the absorption of chromium by plants, which directly affected the organization of epidermal cells and leaf mesophyll. In addition, intense cytoplasmic degradation, ultrastructural changes in chloroplasts and mitochondria, and an increase in autophagic vacuoles were observed. We conclude that increasing the amount of humus in substrate with tannery sludge provides higher quality coffee seedlings, despite promoting greater absorption of chromium by plants and the consequent major intracellular disturbances.

https://doi.org/10.1590/0034-737x202370010010

Health in prison: coronavirus disease 2019's challenges in the Brazilian criminal justice system
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Paiva, João Paulo Silva de

; Leal, Thiago Cavalcanti

; Silva, Leonardo Feitosa da

; Santos, Lucas Gomes

; Santana, Gibson Barros de Almeida

; Machado, Michael Ferreira

; Souza, Carlos Dornels Freire de

Revista da Associação Médica Brasileira

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Jan 2023, Volume 69 Nº 1 Páginas 186 - 190

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/1806-9282.20210889

BRAZILIAN SOCIETY OF HEPATOLOGY UPDATED RECOMMENDATIONS FOR SYSTEMIC TREATMENT OF HEPATOCELLULAR CARCINOMA
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CHAGAS, Aline Lopes

; LEAL, Cassia Regina Guedes

; MELLO, Vivianne Barreto de

; BARROS, Fábio Marinho Do Rego

; BITTENCOURT, Paulo Lisboa

; MATTOS, Angelo A

; AROUCHA, Dayse

; FONSECA, Leonardo G da

; SILVA, Joyce Roma Lucas de

; DOTTORI, Mariana Fonseca

; TEIXEIRA, Rosangela

; MENDES, Liliana Sampaio Costa

; REZENDE, Rosamar Eulira Fontes

; FILGUEIRA, Norma Arteiro

; COUTINHO, Anelisa K

; ARAÚJO NETO, João Marcello de

; COELHO, Henrique Sergio Moraes

; PESSOA, Mario Guimarães

; CHEINQUER, Hugo

; PARISE, Edison Roberto

; FRANÇA, Alex

; ÁLVARES-DA-SILVA, Mário Reis

; CARRILHO, Flair José

; CORAL, Gabriela P

; PINTO, Paulo de Tarso Aparecida

; PEREIRA, Leila M M Beltrão

; PARANÁ, Raymundo

; ALVES, Rogério Camargo Pinheiro

; BRANDÃO-MELLO, Carlos Eduardo

Arquivos de Gastroenterologia

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Jan 2023, Volume 60 Nº 1 Páginas 106 - 131

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide. The Brazilian Society of Hepatology (SBH) published in 2020 the updated recommendations for the diagnosis and treatment of HCC. Since then, new data have emerged in the literature, including new drugs approved for the systemic treatment of HCC that were not available at the time. The SBH board conducted an online single-topic meeting to discuss and review the recommendations on the systemic treatment of HCC. The invited experts were asked to conduct a systematic review of the literature on each topic related to systemic treatment and to present the summary data and recommendations during the meeting. All panelists gathered together for discussion of the topics and elaboration of the updated recommendations. The present document is the final version of the reviewed manuscript containing the recommendations of SBH and its aim is to assist healthcare professionals, policy-makers, and planners in Brazil and Latin America with systemic treatment decision-making of patients with HCC.

RESUMO O carcinoma hepatocelular (CHC) é uma das principais causas de mortalidade relacionada a câncer no Brasil e no mundo. A Sociedade Brasileira de Hepatologia (SBH) publicou em 2020 a atualização das recomendações da SBH para o diagnóstico e tratamento do CHC. Desde então, novas evidências científicas sobre o tratamento sistêmico do CHC foram relatadas na literatura médica, incluindo novos medicamentos aprovados que não estavam disponíveis na época do último consenso, levando a diretoria da SBH a promover uma reunião monotemática on-line para discutir e rever as recomendações sobre o tratamento sistêmico do CHC. Um grupo de experts foi convidado para realizar uma revisão sistemática da literatura e apresentar uma atualização, baseada em evidências científicas, sobre cada tópico relacionado ao tratamento sistêmico e a apresentar os dados e recomendações resumidas durante a reunião. Todos os painelistas se reuniram para discutir os tópicos e elaborar as recomendações atualizadas. O presente documento é a versão final do manuscrito revisado, contendo as recomendações da SBH, e seu objetivo é auxiliar os profissionais de saúde, formuladores de políticas e planejadores no Brasil e na América Latina na tomada de decisões sobre o tratamento sistêmico de pacientes com CHC.

https://doi.org/10.1590/s0004-2803.202301000-14

Translation, cross-cultural adaptation, and validation of the Behavioral Activity Rating Scale (BARS) for the Brazilian population
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Pereira, Lucas Alves

; da Silva, Antônio Geraldo

; Hemanny, Curt

; de Jesus, Rogério

; Moromizato, Maíra

; Vieira, Túlio

; Souza, Murilo

; Lima, Manuela Garcia

; Baldaçara, Leonardo

Trends in Psychiatry and Psychotherapy

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2023, Volume 45 elocation e20210310

Resumo: En | Texto: En | PDF: En

Abstract Introduction Few instruments are available in Brazil to evaluate psychomotor activity in psychiatric emergency, clinical, and research settings. This study aimed to perform a cross-cultural adaptation of the Behavioral Activity Rating Scale (BARS) into Brazilian Portuguese and assess the adapted scale’s psychometric properties. Method An expert consensus committee conducted a translation and back-translation of the original scale, resulting in the BARS-BR. Four pairs of physicians administered the BARS-BR and the Sedation-Agitation Scale (SAS) to patients in a hospital psychiatry emergency room and patients in the hospital’s psychiatric wards. The BARS-BR was compared to the SAS to assess concurrent validity and internal consistency was evaluated with the Bland-Altman technique. Results In the emergency room, the correlation coefficients between the first and second assessments were rho = 0.997 and rho = 1.0, respectively. In the hospital wards, the correlation coefficient between the pair of evaluators was rho = 0.951. There were strong correlations between the BARS-BR score of the first examiner and the SAS score of the second examiner (rho = 0.903) and between the SAS score of the first examiner and the BARS-BR score of the second examiner (rho = 0.893). Conclusion The BARS-BR showed good psychometric properties, and we recommend its use because it constitutes an easy method for assessment of changes in psychomotor activity. Further studies are suggested to evaluate adoption and comprehension of the BARS-BR scale by all classes of healthcare professionals.

https://doi.org/10.47626/2237-6089-2021-0310

Repeatability estimates in longitudinal data on guava trees
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Silva, Flavia Alves da

; Viana, Alexandre Pio

; Corrêa, Caio Cezar Guedes

; Leal, Lucas Souza da Silva

; Glória, Leonardo Siqueira

Scientia Agricola

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2023, Volume 80 elocation e20220065

Resumo: En | Texto: En | PDF: En

ABSTRACT The use of longitudinal measurements is an essential practice both in Psidium guajava L. breeding and in other perennial crops in which covariance structures can be introduced to explain the form of dependence between measurements. Hence, this study aimed to analyze six covariance structures to identify one that best described the correlation between the repeated measurements in time in traits of guava full-sib families. The repeatability coefficient for each trait was estimated and the minimum number of evaluations required for estimates representing the population was determined. The work was performed based on average data of three yield-related variables from nine harvests of a guava tree population evaluated from 2011 to 2018. The best model was chosen based on the Akaike and Schwarz Bayesian information criterion. The autoregressive covariance structure best represented the dependencies among families between crops for all traits. The number of variables of fruits and total yield per plant presented repeatability estimates higher than 0.5 and may be essential traits for indirect selection of others, such as fruit mass, which had an estimated repeatability of 0.24, proving low regularity in the repetition of the character from one cycle to another. It was also possible to define four harvests as the minimum acceptable number of observations necessary on the same individual for these traits; therefore, the repetitions represented the individuals.

https://doi.org/10.1590/1678-992x-2022-0065

COPING IN SOCCER ATHLETES: A SYSTEMATIC REVIEW
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Silva, Adson Alves da

; Freire, Gabriel Lucas Morais

; Fortes, Leonardo de Sousa

; Moraes, José Fernando Vila Nova de

; Carvalho, Rodrigo Gustavo da Silva

; Nascimento Junior, José Roberto Andrade do

Journal of Physical Education

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2023, Volume 34 elocation e3412

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: Review the studies that investigated coping in soccer. Methods: A systemic search was carried out in the following databases: Pubmed, Web of Science, Scielo, Scopus, PsychINFO and SPORTDiscus. The descriptors related to the terms (Coping skills, Sport and Football) were verified in the MeSH (Medical Subject Headings) database. The inclusion criteria used were: Empirical studies published in journals peer-reviewed scientific papers; b) Studies published from December 2014 to December 2019; c) with at least one quantitative measure; d) Studies with samples of soccer athletes; and e) Articles with specific reference to the topic 'Coping skills'. Results: The results showed that coping skills interact with important variables for good performance in elite soccer, such as competitive level, sports talent, psychopathologies, age group and sex. More specifically, it was noted that the development of some coping strategies, such as facing adversity, trust/motivation and performance under pressure, are potentially common to these variables. Conclusion: It is concluded that the development of some coping strategies is fundamental to the elite athlete, since it is positively associated with the optimal development of most of the variables analyzed in the synthesized studies.

RESUMO Objetivo: Revisar sistematicamente os estudos que investigaram o coping no futebol. Métodos: Foi realizada busca sistêmica nas seguintes bases de dados: Pubmed, Web of Science, Scielo, Scopus, PsychINFO e SPORTDiscus. Os descritores relacionados aos termos (Habilidades de enfrentamento, Esporte e Futebol) foram verificados na base de dados MeSH (Medical Subject Headings). Os critérios de inclusão utilizados foram: Estudos empíricos publicados em periódicos artigos científicos revisados por pares; b) Estudos publicados de dezembro de 2014 a dezembro de 2019; c) com pelo menos uma medida quantitativa; d) Estudos com amostras de atletas de futebol; e e) Artigos com referência específica ao tema 'Habilidades de enfrentamento'. Resultados: Os resultados mostraram que as habilidades de enfrentamento interagem com variáveis importantes para o bom desempenho no futebol de elite, como nível competitivo, talento esportivo, psicopatologias, faixa etária e sexo. Mais especificamente, notou-se que o desenvolvimento de algumas estratégias de enfrentamento, como enfrentar adversidades, confiança/motivação e desempenho sob pressão, são potencialmente comuns a essas variáveis. Conclusão: Conclui-se que o desenvolvimento de algumas estratégias de enfrentamento é fundamental para o atleta de elite, pois está positivamente associado ao desenvolvimento ótimo da maioria das variáveis analisadas nos estudos sintetizados.

https://doi.org/10.4025/jphyseduc.v34i1.3412

10.

Epidemiological profile of COVID-19 in patients with prostate cancer undergoing androgen deprivation therapy at a Brazilian Cancer Center
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Travalini, Isabela Granato

; Vergamini, Lucas Bonachi

; Silva, Ivan Leonardo Avelino Franca e

; Caruso, Pedro

; Orellana, Fernanda Monteiro

; Curado, Maria Paula

; Zequi, Stênio de Cássio

einstein (São Paulo)

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2023, Volume 21 elocation eAO0273

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective To describe the epidemiological aspects of COVID-19 in patients with prostate cancer who received androgen deprivation therapy and those who did not. Methods We retrospectively analyzed the medical records of patients with prostate cancer undergoing androgen deprivation therapy and those who did not undergo androgen deprivation therapy. These patients were treated at the A.C.Camargo Cancer Center between March 2020 and March 2021. Results Of the 78 patients with prostate cancer and positive RT-PCR test results, 50% were undergoing androgen deprivation therapy, and 49% were experiencing a non-metastatic biochemical relapse. Of these, 80.6% were symptomatic on the day of examination compared to 97.2% in the Control Group. A total of 82.1% of the patients receiving androgen deprivation therapy required hospitalization, with 30.8% admitted to the intensive care unit compared to 21.6% in the Control Group. There was no statistically significant difference in the use of a high-flow oxygen cannula, the need for orotracheal intubation and mechanical ventilation, the need for dialysis, multiple organ failure, or death. A significant difference was found between the groups in terms of the average length of stay in the intensive care unit. Conclusion Androgen deprivation therapy was not associated with protective factors or potential treatments in patients with prostate cancer and COVID-19. Although the number of patients analyzed was limited, and there may have been a selection bias, this is a unique study that cannot be expanded or replicated in similar (unvaccinated) populations.

https://doi.org/10.31744/einstein_journal/2023ao0273

11.

Assessing Endoscopic Suture Performance of Gynecology and Obstetrics Residents Following Methodic Training
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Nogueira, Lucas Ribeiro

; Lustosa, Kathiane Augusto

; Galindo, Larissa Almeida Oliveira

; Castro, Stephany Ellen de

; Picanço, Liz Rodrigues

; Silva, Lucas Lima da

; Coutinho, Samuel Soares

; Bezerra, Leonardo Robson Pinheiro Sobreira

Revista Brasileira de Ginecologia e Obstetrícia

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2023, Volume 45 Nº 10 Páginas 603 - 608

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Objective To evaluate the performance of residents in gynecology and obstetrics before and after practicing laparoscopic sutures, to establish when the training shows the best results, in addition to comparing whether being in different years of residency influences this progression. Methods A prospective cohort study involving 32 medical residents evaluated with a pretest to establish their previous knowledge in laparoscopic suture. This test consisted of knotting two wires, one made of polypropylene and the other of polyglactin, with a blocking sequence of five semi-knots. We set a 30-minute limit to complete the task. Then, the residents held four training meetings, focusing on suture, Gladiator rule, knot, and symmetries, in addition to executing blocking sequences. A second test to establish progress was performed. Results Regarding the time spent to make the stiches using polyglactin wire, a statistically significant time improvement (p< 0.01) was observed, with a 10.67-minute pretraining median (mean 12.24 minutes) and a 2.53-minute posttraining median (mean 3.25 minutes). Regarding the stitches with polypropylene wire, a statistically significant time improvement (p< 0.05) was also observed, with a 9.38-minute pretraining median (mean 15.43 minutes) and a 3.65-minute posttraining median (mean 4.54 minutes). A total of 64.2% of the residents had been able to make the knot with polypropylene previously. One hundred percent were able to complete the task in the posttest. Conclusion Model training using the Gladiator rule for laparoscopic suture improves the knotting time with statistically similar performance, regardless of the year of residency, after systematic training.

Resumo Objetivo Avaliar a performance de residentes em ginecologia e obstetrícia antes e depois de praticarem suturas laparoscópicas, com o intuito de estabelecer quando o treinamento mostra os melhores resultados, comparando se estar em diferentes da residência influencia essa progressão. Métodos Um estudo coorte prospectivo envolvendo 32 médicos residentes avaliados com um teste pré-treinamento para avaliar seus conhecimentos prévios em sutura laparoscópica. Esse teste consistia em atar nós em dois fios, um de polipropileno e o outro de poliglactina, com uma sequencia de bloqueio de cinco seminós. Definiu-se um limite de 30 minutos para se completar a tarefa. Depois, os residentes tiveram quatro reuniões de treinamento, focadas em sutura, técnica da Regra do Gladiador, nós e simetria, executando, ainda, uma sequência de pontos. Um segundo teste foi feito para avaliar o progresso. Resultados Com relação ao tempo para realizarem os pontos com fio de poliglactina, uma melhora de tempo estatisticamente significativa (p< 0.01) foi observada, com uma mediana de 10.67 minutos no pré-treinamento (média de 12.24 minutos) e uma mediana de 2.53 minutos no pós-treinamento (média de 3.25 minutos). Com relação ao fio de polipropileno, uma melhora de tempo estatisticamente significativa (p< 0.05) também foi observada, com uma mediana de pré-treinamento de 9.38 minutos (média de 15.43 minutos) e uma mediana de pós-treinamento de 3.65 minutos (média de 4.54 minutos). Um total de 64.2% dos residentes foram capazes de realizar os nós com polipropileno inicialmente. Cem por cento do residentes foram capazes de completar a tarefa no pós-teste. Conclusão O modelo de treino usando a técnica da Regra do Gladiador para sutura laparoscópica melhora o tempo de atar nós com uma performance estatisticamente similar, não havendo diferenças quanto ao ano da residência, após treinamento sistematizado.

https://doi.org/10.1055/s-0043-1772476

12.

Corticioid and poroid fungi from Brazilian Cerrado: a history of research and a checklist of species
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LEONARDO-SILVA, LUCAS

; XAVIER-SANTOS, SOLANGE

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Supl. 2 elocation e20220165

Resumo: En | Texto: En | PDF: En

Abstract Corticioid and poroid fungi are widely known for wood decomposition which confers an important ecological role and biotechnological properties upon these species. Although being one of the most studied groups of fungi worldwide, data on diversity and geographic occurrence patterns in Brazil are insufficient, especially in poorly studied areas, including the Cerrado biome. Here we present an overview of the scientific literature concerning the corticioid and poroid fungi from Cerrado, along with a list of species found in the biome so far. The historic research at Cerrado comprised 47 articles published between 1876 and 2021, of which 55% were published in the last decade. We found 387 records and 223 species, while 94 species are new additions to the checklists published in the last decade. Six of the listed species are endemic to Cerrado. Furthermore, 29 species are only known from Cerrado in Brazil, although they occur in other regions of the world. The main research groups focused on these fungi in Brazil have already published at least one article with samples from Cerrado. Therefore, intensifying studies throughout Cerrado could help in a better understanding of its Funga, its evolutionary relationship, and its threatens status.

https://doi.org/10.1590/0001-3765202320220165

13.

Assessment of morphophysiological and genotypic diversity of endophytic bacteria isolated from rice (Oryza sativa L.) plants
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Leonardo-Silva, Lucas

; Silva, Larissa B. da

; Ferreira, Enderson P. de B.

; Reis, Karina F. D. N. S. dos

; Naves, Plínio L. F.

; Martin-Didonet, Claudia C. G.

Revista Caatinga

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2023, Volume 36 Nº 4 Páginas 775 - 784

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Rice production in Brazil incurs high costs due to the significant use of agrochemicals. Some plant growth-promoting rhizobacteria (PGPR) can be used as alternative to fertilizers and phytosanitary products. Thus, the objective of this study was to characterize endophytic bacteria isolated from roots of rice plants. The isolates were characterized based on colony morphology, antibiotic resistance, carbon sources utilization, enzyme activity (catalase, amylase, protease, cellulase, and lipase), inorganic phosphate solubilization, and the 16S-23S rDNA intergenic region. Morphologically, 68% of the isolates presented a rapid growth rate, 46% presented abundant mucus production, and 77% formed viscous colonies. All isolates were resistant to nalidixic acid and 16% presented resistance to streptomycin. The majority (90%) used monosaccharides and disaccharides in carbon source assays. Most of the isolates (95%) were positive for catalase and 63.6% were positive for amylase, protease, lipase, and cellulase activities. Additionally, 59% of them were able to solubilize phosphate. The mean enzymatic index for amylase, cellulase, and protease was 2.8, 3.5, and 1.7 respectively. The similarity analysis revealed high diversity among the isolates, with similarity indices of 70% (based on morphological characteristics) and 60% (based on the intergenic region 16S-23S rDNA). Considering morphophysiological and genotypic characteristics, three promising isolates should be evaluated in studies under field conditions for the potential development of bioproducts to replace industrially manufactured inputs in rice crops.

RESUMO O arroz apresenta altos custos de produção no Brasil devido ao elevado uso de agroquímicos. Algumas rizobactérias promotoras de crescimento de plantas (PGPR) podem ser utilizadas como alternativa aos fertilizantes e produtos fitossanitários. Este trabalho teve como objetivo caracterizar bactérias endofíticas obtidas de raízes de arroz. A caracterização dos isolados foi baseada na morfologia da colônia, resistência a antibióticos, uso de fontes de carbono, atividade enzimática (catalase, amilase, protease, celulase e lipase), solubilização de fosfato inorgânico e região intergênica do 16S-23S rDNA. Com base na morfologia, 68% dos isolados apresentaram crescimento rápido, 46% apresentaram produção abundante de muco e 77% apresentaram colônia viscosa. Todos os isolados foram resistentes ao ácido nalidíxico e 16% deles à estreptomicina. A maioria dos isolados (90%) utilizou monossacarídeos e dissacarídeos no ensaio da fonte de carbono. A maioria dos isolados (95%) foi positiva para catalase e 63,6% foram positivas para amilase, protease, lipase e celulase. Além disso, 59% foram capazes de solubilizar o fosfato. A média do índice enzimático para amilase, celulase e protease foi de 2,8, 3,5 e 1,7, respectivamente. A análise de similaridade revelou alta diversidade entre os isolados, com índice de similaridade de 70% (baseado nas características morfológicas) e 60% (baseado na análise da região intergênica 16S-23S rDNA). Com base nas características morfofisiológicas e genotípicas, três isolados promissores devem ser avaliados em estudos futuros em condições de campo, podendo gerar bioprodutos destinados a substituir insumos industrializados na cultura do arroz.

https://doi.org/10.1590/1983-21252023v36n405rc

14.

Efeitos da solução balanceada em desfechos de curto prazo em pacientes com traumatismo craniencefálico: uma análise secundária do ensaio clínico randomizado BaSICS
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Zampieri, Fernando Godinho

; Damiani, Lucas Petri

; Biondi, Rodrigo Santos

; Freitas, Flávio Geraldo Rezende

; Veiga, Viviane Cordeiro

; Figueiredo, Rodrigo Cruvinel

; Serpa-Neto, Ary

; Manoel, Airton Leonardo de Oliveira

; Miranda, Tamiris Abait

; Corrêa, Thiago Domingos

; Azevedo, Luciano César Pontes de

; Silva, Nilton Brandão da

; Machado, Flavia Ribeiro

; Cavalcanti, Alexandre Biasi

Revista Brasileira de Terapia Intensiva

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Dez 2022, Volume 34 Nº 4 Páginas 410 - 417

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Objective: To describe the effects of balanced solution use on the short-term outcomes of patients with traumatic brain injury enrolled in BaSICS trial. Methods: Patients were randomized to receive either 0.9% saline or balanced solution during their intensive care unit stay. The primary endpoint was 90-day mortality, and the secondary outcomes were days alive and free of intensive care unit stay at 28 days. The primary endpoint was assessed using Bayesian logistic regression. The secondary endpoint was assessed using a Bayesian zero-inflated beta binomial regression. Results: We included 483 patients (236 in the 0.9% saline arm and 247 in the balanced solution arm). A total of 338 patients (70%) with a Glasgow coma scale score ≤ 12 were enrolled. The overall probability that balanced solutions were associated with higher 90-day mortality was 0.98 (OR 1.48; 95%CrI 1.04 - 2.09); this mortality increment was particularly noticeable in patients with a Glasgow coma scale score below 6 at enrollment (probability of harm of 0.99). Balanced solutions were associated with -1.64 days alive and free of intensive care unit at 28 days (95%CrI -3.32 - 0.00) with a probability of harm of 0.97. Conclusion: There was a high probability that balanced solutions were associated with high 90-day mortality and fewer days alive and free of intensive care units at 28 days. ClinicalTrials.gov:NCT02875873

RESUMO Objetivo: Descrever os efeitos do uso de soluções balanceadas nos desfechos de curto prazo de pacientes com traumatismo craniencefálico incluídos no estudo BaSICS. Métodos: Os pacientes foram randomizados para receber solução salina 0,9% ou solução balanceada durante a internação em unidade de terapia intensiva. O desfecho primário foi mortalidade em 90 dias, já os desfechos secundários foram dias de vida e sem internação em unidade de terapia intensiva aos 28 dias. O desfecho primário foi avaliado por regressão logística bayesiana. O desfecho secundário foi avaliado usando regressão beta-binomial inflada de zeros bayesiana. Resultados: Incluímos 483 pacientes (236 no braço de solução salina 0,9% e 247 no braço de solução balanceada). Foram incluídos 338 pacientes (70%) com pontuação na escala de coma de Glasgow ≤ 12. A probabilidade geral de que soluções balanceadas estivessem associadas a maior mortalidade em 90 dias foi de 0,98 (RC de 1,48; ICr95% 1,04 - 2,09). Esse aumento de mortalidade foi particularmente perceptível em pacientes com pontuação na escala de coma de Glasgow abaixo de 6 no momento da inclusão (probabilidade de dano de 0,99). Soluções balanceadas foram associadas a -1,64 dia de vida e sem internação em unidade de terapia intensiva aos 28 dias (ICr95% -3,32 - 0,00) com probabilidade de dano de 0,97. Conclusão: Houve alta probabilidade de que soluções balanceadas estivessem associadas a alta mortalidade em 90 dias, menos dias de vida e sem internação em unidade de terapia intensiva aos 28 dias. ClinicalTrials.gov:NCT02875873

https://doi.org/10.5935/0103-507x.20220261-pt

15.

[SciELO Preprints] - FEMALE AUTOBIOGRAPHIC NARRATIVES ABOUT POSTPARTUM DEPRESSION ON YOUTUBE®: A QUALITATIVE STUDY
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Silva, Marília da Mata Oliveira, Leonardo Pestillo de Marques, Andrea Grano Garcia, Lucas

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Data de publicação: 2022-05-10

Resumo: En Es Pt

With the tremendous technological advance, women have access to sharing information on social networks, expanding the interaction and discussion of their experiences of motherhood. This study aimed to analyze female autobiographical narratives about postpartum depression published on the Youtube® platform. A qualitative study was carried out from a sample of 2, classified by their company and published in the last five years by health professionals. It can be respected if the YouTube® platform is used as a site where women frequently turn to exchange postpartum experiences. It is also essential to highlight the importance of creating videos of professional treatment for education for post-participation character education, disseminating information that they seek in scientific research, and providing information for professional education.

Con el tremendo avance tecnológico, las mujeres tienen acceso a compartir información en las redes sociales, ampliando la interacción y discusión de sus experiencias de maternidad. Este estudio tuvo como objetivo analizar las narrativas autobiográficas femeninas sobre la depresión posparto publicadas en la plataforma Youtube®. Se realizó un estudio cualitativo a partir de una muestra de 2, clasificados por su empresa y publicados en los últimos cinco años por profesionales de la salud. Se puede respetar si la plataforma de YouTube® se utiliza como un sitio donde las mujeres acuden con frecuencia para intercambiar experiencias posparto. También es fundamental resaltar la importancia de crear videos de tratamiento profesional para la formación del carácter post-participación, difundir la información que buscan en la investigación científica y brindar información para la formación profesional.

Com o grande avanço tecnológico, as mulheres têm tido acesso tanto à criação quanto ao compartilhamento de informações nas redes sociais sobre a maternidade, ampliando a interação e a discussão de suas experiências acerca da maternidade. O objetivo deste estudo foi analisar as narrativas autobiográficas femininas sobre a depressão pós-parto publicadas na plataforma Youtube®. Foi realizado um estudo qualitativo a partir de uma amostra de 26 vídeos, classificados por sua relevância e publicados nos últimos cinco anos por profissionais da saúde. Pode-se concluir que a plataforma do YouTube® é utilizada como um site onde as mulheres recorrem com frequência para troca de experiências a respeito da depressão pós-parto. Ressalta-se, ainda, a importância da criação de vídeos de caráter educativo que visem desmistificar a busca por tratamento profissional para a depressão pós-parto, disseminando informações baseadas em evidências científicas e eficazes.

https://doi.org/10.1590/SciELOPreprints.4098

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