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Importance of genetic cancer risk assessment as a strategy to stratify risk and provide precision prevention in high-risk patients and families highrisk high
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Ashton-Prolla, Patricia
; Achatz, Maria Isabel Waddington
; Moreira, Miguel Angelo Martins
; Palmero, Edenir Inez
; Soares, Diogo Cordeiro de Queiroz
; Ferraz, Victor Evangelista de Faria
; Caires, Inacelli Queiroz de Souza
; Guindalini, Rodrigo Santa Cruz
; Gifoni, Ana Carolina Leite Vieira Costa
.
Revista da Associação Médica Brasileira
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2.
Unraveling clinical outcomes of long-term cART treatment in HIV-1 patients with or without the Brazilian GWGR motif in the V3 loop longterm long term HIV1 HIV 1 HIV- V
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Folgosi, Victor Ângelo
; Komninakis, Shirley Vasconcelos
; Lopes, Luciano
; Monteiro, Mariana Amélia
; Assone, Tatiane
; Fonseca, Luiz Augusto Marcondes
; Domingues, Wilson
; Leite Junior, Pedro Domingos
; Victor, Jefferson Russo
; Casseb, Jorge
.
Revista do Instituto de Medicina Tropical de São Paulo
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ABSTRACT The presence of genetic mutations in HIV poses a significant challenge, potentially leading to antiretroviral resistance and hampering therapeutic development. The Brazilian population has presented variations in the HIV envelope V3 loop gene, especially the GWGR motif. This motif has been linked to reduced transmission potential and slower CD4+ T cell decline. This study aimed to assess clinical outcomes in patients with HIV-1 infected with strains containing the GWGR motif compared with those without it during long-term cART. A cohort of 295 patients with HIV was examined for the GWGR motif presence in the V3 loop. A total of 58 samples showed the GWGR signature, while 237 had other signatures. Multifactorial analyses showed no significant differences in demographic characteristics, CD4+ cell count, AIDS progression, or mortality between GWGR carriers and others. However, the mean interval between the first positive HIV test and the initial AIDS-defining event was more than two times longer for women carrying the GWGR signature (p = 0.0231). We emphasize the positive impact of cART on HIV/AIDS treatment, including viral suppression, CD4+ cell preservation, and immune function maintenance. Although no significant differences were found during cART, residual outcomes reflecting adherence challenges were observed between diagnosis and the first AIDS-defining event. The previously described outcomes, highlighting statistically significant differences between individuals carrying the GPGR motif compared with those with the Brazilian GWGR motif, may be directly linked to the natural progression of infection before advancements in cART. Presently, these physicochemical aspects may no longer hold the same relevance. challenge development V gene CD4 CD decline HIV1 1 HIV- longterm long term 29 5 23 signatures characteristics count others However AIDSdefining defining p 0.0231. 00231 0.0231 . 0 0231 0.0231) HIVAIDS treatment suppression preservation maintenance Presently relevance 2 0023 0.023 023 002 0.02 02 00 0.0 0.
3.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
; Slipinski, Adam
; Linzmeier, Adelita M.
; Calor, Adolfo R.
; Garda, Adrian A.
; Kury, Adriano B.
; Fernandes, Agatha C.S.
; Agudo-Padrón, Aisur I.
; Akama, Alberto
; Silva Neto, Alberto M. da
; Burbano, Alejandro L.
; Menezes, Aleksandra
; Pereira-Colavite, Alessandre
; Anichtchenko, Alexander
; Lees, Alexander C.
; Bezerra, Alexandra M.R.
; Domahovski, Alexandre C.
; Pimenta, Alexandre D.
; Aleixo, Alexandre L.P.
; Marceniuk, Alexandre P.
; Paula, Alexandre S. de
; Somavilla, Alexandre
; Specht, Alexandre
; Camargo, Alexssandro
; Newton, Alfred F.
; Silva, Aline A.S. da
; Santos, Aline B. dos
; Tassi, Aline D.
; Aragão, Allan C.
; Santos, Allan P.M.
; Migotto, Alvaro E.
; Mendes, Amanda C.
; Cunha, Amanda
; Chagas Júnior, Amazonas
; Sousa, Ana A.T. de
; Pavan, Ana C.
; Almeida, Ana C.S.
; Peronti, Ana L.B.G.
; Henriques-Oliveira, Ana L.
; Prudente, Ana L.
; Tourinho, Ana L.
; Pes, Ana M.O.
; Carmignotto, Ana P.
; Wengrat, Ana P.G. da Silva
; Dornellas, Ana P.S.
; Molin, Anamaria Dal
; Puker, Anderson
; Morandini, André C.
; Ferreira, André da S.
; Martins, André L.
; Esteves, André M.
; Fernandes, André S.
; Roza, André S.
; Köhler, Andreas
; Paladini, Andressa
; Andrade, Andrey J. de
; Pinto, Ângelo P.
; Salles, Anna C. de A.
; Gondim, Anne I.
; Amaral, Antonia C.Z.
; Rondón, Antonio A.A.
; Brescovit, Antonio
; Lofego, Antônio C.
; Marques, Antonio C.
; Macedo, Antonio
; Andriolo, Artur
; Henriques, Augusto L.
; Ferreira Júnior, Augusto L.
; Lima, Aurino F. de
; Barros, Ávyla R. de A.
; Brito, Ayrton do R.
; Romera, Bárbara L.V.
; Vasconcelos, Beatriz M.C. de
; Frable, Benjamin W.
; Santos, Bernardo F.
; Ferraz, Bernardo R.
; Rosa, Brunno B.
; Sampaio, Brunno H.L.
; Bellini, Bruno C.
; Clarkson, Bruno
; Oliveira, Bruno G. de
; Corrêa, Caio C.D.
; Martins, Caleb C.
; Castro-Guedes, Camila F. de
; Souto, Camilla
; Bicho, Carla de L.
; Cunha, Carlo M.
; Barboza, Carlos A. de M.
; Lucena, Carlos A.S. de
; Barreto, Carlos
; Santana, Carlos D.C.M. de
; Agne, Carlos E.Q.
; Mielke, Carlos G.C.
; Caetano, Carlos H.S.
; Flechtmann, Carlos H.W.
; Lamas, Carlos J.E.
; Rocha, Carlos
; Mascarenhas, Carolina S.
; Margaría, Cecilia B.
; Waichert, Cecilia
; Digiani, Celina
; Haddad, Célio F.B.
; Azevedo, Celso O.
; Benetti, Cesar J.
; Santos, Charles M.D. dos
; Bartlett, Charles R.
; Bonvicino, Cibele
; Ribeiro-Costa, Cibele S.
; Santos, Cinthya S.G.
; Justino, Cíntia E.L.
; Canedo, Clarissa
; Bonecker, Claudia C.
; Santos, Cláudia P.
; Carvalho, Claudio J.B. de
; Gonçalves, Clayton C.
; Galvão, Cleber
; Costa, Cleide
; Oliveira, Cléo D.C. de
; Schwertner, Cristiano F.
; Andrade, Cristiano L.
; Pereira, Cristiano M.
; Sampaio, Cristiano
; Dias, Cristina de O.
; Lucena, Daercio A. de A.
; Manfio, Daiara
; Amorim, Dalton de S.
; Queiroz, Dalva L. de
; Queiroz, Dalva L. de
; Colpani, Daniara
; Abbate, Daniel
; Aquino, Daniel A.
; Burckhardt, Daniel
; Cavallari, Daniel C.
; Prado, Daniel de C. Schelesky
; Praciano, Daniel L.
; Basílio, Daniel S.
; Bená, Daniela de C.
; Toledo, Daniela G.P. de
; Takiya, Daniela M.
; Fernandes, Daniell R.R.
; Ament, Danilo C.
; Cordeiro, Danilo P.
; Silva, Darliane E.
; Pollock, Darren A.
; Muniz, David B.
; Gibson, David I.
; Nogueira, David S.
; Marques, Dayse W.A.
; Lucatelli, Débora
; Garcia, Deivys M.A.
; Baêta, Délio
; Ferreira, Denise N.M.
; Rueda-Ramírez, Diana
; Fachin, Diego A.
; Souza, Diego de S.
; Rodrigues, Diego F.
; Pádua, Diego G. de
; Barbosa, Diego N.
; Dolibaina, Diego R.
; Amaral, Diogo C.
; Chandler, Donald S.
; Maccagnan, Douglas H.B.
; Caron, Edilson
; Carvalho, Edrielly
; Adriano, Edson A.
; Abreu Júnior, Edson F. de
; Pereira, Edson H.L.
; Viegas, Eduarda F.G.
; Carneiro, Eduardo
; Colley, Eduardo
; Eizirik, Eduardo
; Santos, Eduardo F. dos
; Shimbori, Eduardo M.
; Suárez-Morales, Eduardo
; Arruda, Eliane P. de
; Chiquito, Elisandra A.
; Lima, Élison F.B.
; Castro, Elizeu B. de
; Orlandin, Elton
; Nascimento, Elynton A. do
; Razzolini, Emanuel
; Gama, Emanuel R.R.
; Araujo, Enilma M. de
; Nishiyama, Eric Y.
; Spiessberger, Erich L.
; Santos, Érika C.L. dos
; Contreras, Eugenia F.
; Galati, Eunice A.B.
; Oliveira Junior, Evaldo C. de
; Gallardo, Fabiana
; Hernandes, Fabio A.
; Lansac-Tôha, Fábio A.
; Pitombo, Fabio B.
; Dario, Fabio Di
; Santos, Fábio L. dos
; Mauro, Fabio
; Nascimento, Fabio O. do
; Olmos, Fabio
; Amaral, Fabio R.
; Schunck, Fabio
; Godoi, Fábio S. P. de
; Machado, Fabrizio M.
; Barbo, Fausto E.
; Agrain, Federico A.
; Ribeiro, Felipe B.
; Moreira, Felipe F.F.
; Barbosa, Felipe F.
; Silva, Fenanda S.
; Cavalcanti, Fernanda F.
; Straube, Fernando C.
; Carbayo, Fernando
; Carvalho Filho, Fernando
; Zanella, Fernando C.V.
; Jacinavicius, Fernando de C.
; Farache, Fernando H.A.
; Leivas, Fernando
; Dias, Fernando M.S.
; Mantellato, Fernando
; Vaz-de-Mello, Fernando Z.
; Gudin, Filipe M.
; Albuquerque, Flávio
; Molina, Flavio B.
; Passos, Flávio D.
; Shockley, Floyd W.
; Pinheiro, Francielly F.
; Mello, Francisco de A.G. de
; Nascimento, Francisco E. de L.
; Franco, Francisco L.
; Oliveira, Francisco L. de
; Melo, Francisco T. de V.
; Quijano, Freddy R.B.
; Salles, Frederico F.
; Biffi, Gabriel
; Queiroz, Gabriel C.
; Bizarro, Gabriel L.
; Hrycyna, Gabriela
; Leviski, Gabriela
; Powell, Gareth S.
; Santos, Geane B. dos
; Morse, Geoffrey E.
; Brown, George
; Mattox, George M.T.
; Zimbrão, Geraldo
; Carvalho, Gervásio S.
; Miranda, Gil F.G.
; Moraes, Gilberto J. de
; Lourido, Gilcélia M.
; Neves, Gilmar P.
; Moreira, Gilson R.P.
; Montingelli, Giovanna G.
; Maurício, Giovanni N.
; Marconato, Gláucia
; Lopez, Guilherme E.L.
; Silva, Guilherme L. da
; Muricy, Guilherme
; Brito, Guilherme R.R.
; Garbino, Guilherme S.T.
; Flores, Gustavo E.
; Graciolli, Gustavo
; Libardi, Gustavo S.
; Proctor, Heather C.
; Gil-Santana, Helcio R.
; Varella, Henrique R.
; Escalona, Hermes E.
; Schmitz, Hermes J.
; Rodrigues, Higor D.D.
; Galvão Filho, Hilton de C.
; Quintino, Hingrid Y.S.
; Pinto, Hudson A.
; Rainho, Hugo L.
; Miyahira, Igor C.
; Gonçalves, Igor de S.
; Martins, Inês X.
; Cardoso, Irene A.
; Oliveira, Ismael B. de
; Franz, Ismael
; Fernandes, Itanna O.
; Golfetti, Ivan F.
; S. Campos-Filho, Ivanklin
; Oliveira, Ivo de S.
; Delabie, Jacques H.C.
; Oliveira, Jader de
; Prando, Jadila S.
; Patton, James L.
; Bitencourt, Jamille de A.
; Silva, Janaina M.
; Santos, Jandir C.
; Arruda, Janine O.
; Valderrama, Jefferson S.
; Dalapicolla, Jeronymo
; Oliveira, Jéssica P.
; Hájek, Jiri
; Morselli, João P.
; Narita, João P.
; Martin, João P.I.
; Grazia, Jocélia
; McHugh, Joe
; Cherem, Jorge J.
; Farias Júnior, José A.S.
; Fernandes, Jose A.M.
; Pacheco, José F.
; Birindelli, José L.O.
; Rezende, José M.
; Avendaño, Jose M.
; Duarte, José M. Barbanti
; Ribeiro, José R. Inácio
; Mermudes, José R.M.
; Pujol-Luz, José R.
; Santos, Josenilson R. dos
; Câmara, Josenir T.
; Teixeira, Joyce A.
; Prado, Joyce R. do
; Botero, Juan P.
; Almeida, Julia C.
; Kohler, Julia
; Gonçalves, Julia P.
; Beneti, Julia S.
; Donahue, Julian P.
; Alvim, Juliana
; Almeida, Juliana C.
; Segadilha, Juliana L.
; Wingert, Juliana M.
; Barbosa, Julianna F.
; Ferrer, Juliano
; Santos, Juliano F. dos
; Kuabara, Kamila M.D.
; Nascimento, Karine B.
; Schoeninger, Karine
; Campião, Karla M.
; Soares, Karla
; Zilch, Kássia
; Barão, Kim R.
; Teixeira, Larissa
; Sousa, Laura D. do N.M. de
; Dumas, Leandro L.
; Vieira, Leandro M.
; Azevedo, Leonardo H.G.
; Carvalho, Leonardo S.
; Souza, Leonardo S. de
; Rocha, Leonardo S.G.
; Bernardi, Leopoldo F.O.
; Vieira, Letícia M.
; Johann, Liana
; Salvatierra, Lidianne
; Oliveira, Livia de M.
; Loureiro, Lourdes M.A. El-moor
; Barreto, Luana B.
; Barros, Luana M.
; Lecci, Lucas
; Camargos, Lucas M. de
; Lima, Lucas R.C.
; Almeida, Lucia M.
; Martins, Luciana R.
; Marinoni, Luciane
; Moura, Luciano de A.
; Lima, Luciano
; Naka, Luciano N.
; Miranda, Lucília S.
; Salik, Lucy M.
; Bezerra, Luis E.A.
; Silveira, Luis F.
; Campos, Luiz A.
; Castro, Luiz A.S. de
; Pinho, Luiz C.
; Silveira, Luiz F.L.
; Iniesta, Luiz F.M.
; Tencatt, Luiz F.C.
; Simone, Luiz R.L.
; Malabarba, Luiz R.
; Cruz, Luiza S. da
; Sekerka, Lukas
; Barros, Lurdiana D.
; Santos, Luziany Q.
; Skoracki, Maciej
; Correia, Maira A.
; Uchoa, Manoel A.
; Andrade, Manuella F.G.
; Hermes, Marcel G.
; Miranda, Marcel S.
; Araújo, Marcel S. de
; Monné, Marcela L.
; Labruna, Marcelo B.
; Santis, Marcelo D. de
; Duarte, Marcelo
; Knoff, Marcelo
; Nogueira, Marcelo
; Britto, Marcelo R. de
; Melo, Marcelo R.S. de
; Carvalho, Marcelo R. de
; Tavares, Marcelo T.
; Kitahara, Marcelo V.
; Justo, Marcia C.N.
; Botelho, Marcia J.C.
; Couri, Márcia S.
; Borges-Martins, Márcio
; Felix, Márcio
; Oliveira, Marcio L. de
; Bologna, Marco A.
; Gottschalk, Marco S.
; Tavares, Marcos D.S.
; Lhano, Marcos G.
; Bevilaqua, Marcus
; Santos, Marcus T.T.
; Domingues, Marcus V.
; Sallum, Maria A.M.
; Digiani, María C.
; Santarém, Maria C.A.
; Nascimento, Maria C. do
; Becerril, María de los A.M.
; Santos, Maria E.A. dos
; Passos, Maria I. da S. dos
; Felippe-Bauer, Maria L.
; Cherman, Mariana A.
; Terossi, Mariana
; Bartz, Marie L.C.
; Barbosa, Marina F. de C.
; Loeb, Marina V.
; Cohn-Haft, Mario
; Cupello, Mario
; Martins, Marlúcia B.
; Christofersen, Martin L.
; Bento, Matheus
; Rocha, Matheus dos S.
; Martins, Maurício L.
; Segura, Melissa O.
; Cardenas, Melissa Q.
; Duarte, Mércia E.
; Ivie, Michael A.
; Mincarone, Michael M.
; Borges, Michela
; Monné, Miguel A.
; Casagrande, Mirna M.
; Fernandez, Monica A.
; Piovesan, Mônica
; Menezes, Naércio A.
; Benaim, Natalia P.
; Reategui, Natália S.
; Pedro, Natan C.
; Pecly, Nathalia H.
; Ferreira Júnior, Nelson
; Silva Júnior, Nelson J. da
; Perioto, Nelson W.
; Hamada, Neusa
; Degallier, Nicolas
; Chao, Ning L.
; Ferla, Noeli J.
; Mielke, Olaf H.H.
; Evangelista, Olivia
; Shibatta, Oscar A.
; Oliveira, Otto M.P.
; Albornoz, Pablo C.L.
; Dellapé, Pablo M.
; Gonçalves, Pablo R.
; Shimabukuro, Paloma H.F.
; Grossi, Paschoal
; Rodrigues, Patrícia E. da S.
; Lima, Patricia O.V.
; Velazco, Paul
; Santos, Paula B. dos
; Araújo, Paula B.
; Silva, Paula K.R.
; Riccardi, Paula R.
; Garcia, Paulo C. de A.
; Passos, Paulo G.H.
; Corgosinho, Paulo H.C.
; Lucinda, Paulo
; Costa, Paulo M.S.
; Alves, Paulo P.
; Roth, Paulo R. de O.
; Coelho, Paulo R.S.
; Duarte, Paulo R.M.
; Carvalho, Pedro F. de
; Gnaspini, Pedro
; Souza-Dias, Pedro G.B.
; Linardi, Pedro M.
; Bartholomay, Pedro R.
; Demite, Peterson R.
; Bulirsch, Petr
; Boll, Piter K.
; Pereira, Rachel M.M.
; Silva, Rafael A.P.F.
; Moura, Rafael B. de
; Boldrini, Rafael
; Silva, Rafaela A. da
; Falaschi, Rafaela L.
; Cordeiro, Ralf T.S.
; Mello, Ramon J.C.L.
; Singer, Randal A.
; Querino, Ranyse B.
; Heleodoro, Raphael A.
; Castilho, Raphael de C.
; Constantino, Reginaldo
; Guedes, Reinaldo C.
; Carrenho, Renan
; Gomes, Renata S.
; Gregorin, Renato
; Machado, Renato J.P.
; Bérnils, Renato S.
; Capellari, Renato S.
; Silva, Ricardo B.
; Kawada, Ricardo
; Dias, Ricardo M.
; Siewert, Ricardo
; Brugnera, Ricaro
; Leschen, Richard A.B.
; Constantin, Robert
; Robbins, Robert
; Pinto, Roberta R.
; Reis, Roberto E. dos
; Ramos, Robson T. da C.
; Cavichioli, Rodney R.
; Barros, Rodolfo C. de
; Caires, Rodrigo A.
; Salvador, Rodrigo B.
; Marques, Rodrigo C.
; Araújo, Rodrigo C.
; Araujo, Rodrigo de O.
; Dios, Rodrigo de V.P.
; Johnsson, Rodrigo
; Feitosa, Rodrigo M.
; Hutchings, Roger W.
; Lara, Rogéria I.R.
; Rossi, Rogério V.
; Gerstmeier, Roland
; Ochoa, Ronald
; Hutchings, Rosa S.G.
; Ale-Rocha, Rosaly
; Rocha, Rosana M. da
; Tidon, Rosana
; Brito, Rosangela
; Pellens, Roseli
; Santos, Sabrina R. dos
; Santos, Sandra D. dos
; Paiva, Sandra V.
; Santos, Sandro
; Oliveira, Sarah S. de
; Costa, Sávio C.
; Gardner, Scott L.
; Leal, Sebastián A. Muñoz
; Aloquio, Sergio
; Bonecker, Sergio L.C.
; Bueno, Sergio L. de S.
; Almeida, Sérgio M. de
; Stampar, Sérgio N.
; Andena, Sérgio R.
; Posso, Sergio R.
; Lima, Sheila P.
; Gadelha, Sian de S.
; Thiengo, Silvana C.
; Cohen, Simone C.
; Brandão, Simone N.
; Rosa, Simone P.
; Ribeiro, Síria L.B.
; Letana, Sócrates D.
; Santos, Sonia B. dos
; Andrade, Sonia C.S.
; Dávila, Stephane
; Vaz, Stéphanie
; Peck, Stewart B.
; Christo, Susete W.
; Cunha, Suzan B.Z.
; Gomes, Suzete R.
; Duarte, Tácio
; Madeira-Ott, Taís
; Marques, Taísa
; Roell, Talita
; Lima, Tarcilla C. de
; Sepulveda, Tatiana A.
; Maria, Tatiana F.
; Ruschel, Tatiana P.
; Rodrigues, Thaiana
; Marinho, Thais A.
; Almeida, Thaís M. de
; Miranda, Thaís P.
; Freitas, Thales R.O.
; Pereira, Thalles P.L.
; Zacca, Thamara
; Pacheco, Thaynara L.
; Martins, Thiago F.
; Alvarenga, Thiago M.
; Carvalho, Thiago R. de
; Polizei, Thiago T.S.
; McElrath, Thomas C.
; Henry, Thomas
; Pikart, Tiago G.
; Porto, Tiago J.
; Krolow, Tiago K.
; Carvalho, Tiago P.
; Lotufo, Tito M. da C.
; Caramaschi, Ulisses
; Pinheiro, Ulisses dos S.
; Pardiñas, Ulyses F.J.
; Maia, Valéria C.
; Tavares, Valeria
; Costa, Valmir A.
; Amaral, Vanessa S. do
; Silva, Vera C.
; Wolff, Vera R. dos S.
; Slobodian, Verônica
; Silva, Vinícius B. da
; Espíndola, Vinicius C.
; Costa-Silva, Vinicius da
; Bertaco, Vinicius de A.
; Padula, Vinícius
; Ferreira, Vinicius S.
; Silva, Vitor C.P. da
; Piacentini, Vítor de Q.
; Sandoval-Gómez, Vivian E.
; Trevine, Vivian
; Sousa, Viviane R.
; Sant’Anna, Vivianne B. de
; Mathis, Wayne N.
; Souza, Wesley de O.
; Colombo, Wesley D.
; Tomaszewska, Wioletta
; Wosiacki, Wolmar B.
; Ovando, Ximena M.C.
; Leite, Yuri L.R.
.
ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
4.
Novel approaches for HTLV-1 therapy: innovative applications of CRISPR-Cas9 HTLV1 HTLV 1 HTLV- therapy CRISPRCas9 CRISPRCas CRISPR Cas9 Cas CRISPR-Cas
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Domingues, Wilson
; Folgosi, Victor Ângelo
; Sanabani, Sabri Saeed
; Leite Junior, Pedro Domingos
; Assone, Tatiane
; Casseb, Jorge
.
Revista do Instituto de Medicina Tropical de São Paulo
- Métricas do periódico
ABSTRACT The human T-cell lymphotropic virus type 1 (HTLV-1) is a single-stranded positive-sense RNA virus that belongs to the Retroviridae family, genus Deltaretro, and infects approximately five to 10 million people worldwide. Although a significant number of individuals living with HTLV-1 remain asymptomatic throughout their lives, some develop one or more severe clinical conditions, such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive and debilitating disease, and/or a subtype of non-Hodgkin’s lymphoma with a more threatening course known as adult T-cell leukemia/lymphoma (ATLL). Moreover, current therapeutic options are limited and focus primarily on treating symptoms and controlling viral latency. CRISPR-Cas9 gene editing is proposed as a promising tool to address the intricate links associated with HTLV-1. By targeting or silencing key genes during initial infection and dysregulating immune signaling pathways, CRISPR-Cas9 offers potential intervention opportunities. In this review, we address the therapeutic potential of CRISPR-Cas9 gene editing, as well as examine the primary mechanisms involved in editing potential target genes and discuss the existing evidence in the current scientific literature. Tcell T cell HTLV1 HTLV (HTLV-1 singlestranded single stranded positivesense positive sense family Deltaretro worldwide HTLV- lives conditions HTLV1associated HTLVassociated myelopathytropical myelopathy tropical HAM/TSP, HAMTSP HAM/TSP , HAM TSP (HAM/TSP) disease andor nonHodgkins non Hodgkin s leukemialymphoma leukemia ATLL. ATLL . (ATLL) Moreover latency CRISPRCas9 CRISPRCas CRISPR Cas9 Cas CRISPR-Cas HTLV1. 1. pathways opportunities review literature (HTLV- (HAM/TSP (ATLL (HTLV
5.
Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region 1
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Martins, Luís Felipe Leite
; Moreira, Miguel Ângelo Martins
; Pinto, Rodrigo Alves
; Reis, Neilane Bertoni dos
; Felix, Shayany Pinto
; Vidal, João Paulo Castello Branco
; Torres, Leuridan Cavalcante
; Souza, Ariani Impieri
; Almeida, Liz Maria de
.
Revista Brasileira de Ginecologia e Obstetrícia
- Métricas do periódico
Abstract Objective Similar to Human Papillomavirus (HPV) genotypes, different lineages of a genotype also have different carcinogenic capabilities. Studies have shown that specific genotype lineages of oncogenic HPV are associated with variable risks for the development of cervical intraepithelial neoplasia (CIN2/CIN3) and cervical cancer. The present study aimed to analyze the genetic diversity of the HPV16 genotype in women with CIN2/CIN3 and cervical cancer, from the northeast region of Brazil. Methods A cross-sectional multicenter study was conducted in the northeast region of Brazil, from 2014 to 2016. This study included 196 cases of HPV16 variants (59 and 137 cases of CIN2/CIN3 and cervical cancer, respectively). The difference of proportion test was used to compare patients with CIN2/CIN3 and cervical cancer, based on the prevalent HPV16 lineage (p < 0.05). Results According to the histopathological diagnosis, the percentage of lineage frequencies revealed a marginal difference in the prevalence of lineage A in CIN2/CIN3, compared with that in cervical cancer (p = 0.053). For lineage D, the proportion was higher in cancer cases (32.8%), than in CIN2/CIN3 cases (16.9%), with p = 0.023. Conclusion HPV16 lineage A was the most frequent lineage in both CIN2/CIN3 and cervical cancer samples, while lineage D was predominant in cervical cancer, suggesting a possible association between HPV16 lineage D and cervical cancer. (HPV genotypes capabilities CIN2CIN3 CINCIN CIN2 CIN3 CIN (CIN2/CIN3 HPV1 CIN2/CIN Brazil crosssectional cross sectional 201 2016 19 59 (5 13 respectively. respectively . respectively) 0.05. 005 0.05 0 05 0.05) diagnosis 0.053. 0053 0.053 053 0.053) 32.8%, 328 32.8% , 32 8 (32.8%) 16.9%, 169 16.9% 16 9 (16.9%) 0023 023 0.023 samples CIN2CIN (CIN2/CIN 20 1 5 ( 00 0.0 32.8 3 (32.8% 16.9 (16.9% 002 02 0.02 2 0. 32. (32.8 16. (16.9 (32. (16. (32 (16 (3 (1
Resumo Objetivo Tanto os tipos quanto as linhagens do Papilomavírus Humano (HPV) parecem ter diferentes capacidades carcinogênicas e estão associados a riscos variados para o desenvolvimento de neoplasia intraepitelial cervical (NIC) e câncer de colo do útero. O presente estudo tem como objetivo analisar a diversidade genética do genótipo HPV 16 nos casos de NIC2/NIC3 e câncer de colo de útero em mulheres da região Nordeste do Brasil. Métodos Estudo transversal de base hospitalar realizado na região Nordeste do Brasil no período de 2014 a 2016. A amostra foi composta por 196 casos da variante HPV-16 (59 casos de NIC2/NIC3 e 137 de câncer do colo do útero). O teste de diferença de proporção foi usado para comparar os grupos NIC2/NIC3 e câncer de colo do útero por linhagem viral em relação à prevalência da linhagem HPV-16. Foi considerada significância estatística o valor de p < 0,05. Resultados As frequências de linhagem por diagnóstico histopatológico mostraram diferença limítrofe da linhagem A no grupo NIC2/NIC3 em relação ao grupo câncer de colo de útero (p = 0,053). Por outro lado, em relação à linhagem D, houve uma proporção maior nos casos de câncer (32,8%) quando comparado ao grupo NIC2/NIC3 (16,9%) e esta diferença se mostrou estatisticamente significante (p = 0,023). Conclusão A linhagem A do HPV-16 foi a mais frequente tanto nas amostras CIN2/CIN3 quanto nas amostras de câncer de colo de útero, enquanto a linhagem D predominou no câncer de colo do útero, sugerindo uma possível associação da linhagem D de HPV-16 com câncer de colo de útero. (HPV NIC (NIC 1 NIC2NIC3 NICNIC NIC2 NIC3 NIC2/NIC 201 2016 19 HPV16 HPV-1 59 (5 13 . útero) HPV16. 16. 005 0 05 0,05 0,053. 0053 0,053 053 0,053) lado 32,8% 328 32 8 (32,8% 16,9% 169 9 (16,9% 0,023. 0023 0,023 023 0,023) CIN2CIN3 CINCIN CIN2 CIN3 CIN CIN2/CIN NIC2NIC 20 HPV1 HPV- 5 ( 00 0,0 32,8 3 (32,8 16,9 (16,9 002 0,02 02 CIN2CIN 2 0, 32, (32, 16, (16, (32 (16 (3 (1
6.
DAILY PHYSICAL ACTIVITY IN CHILDREN ENROLLED IN EXTRACURRICULAR ACTIVITY
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ABSTRACT This study aimed to verify and compare the physical activity practices of children enrolled and non-enrolled on different days of week in a specific program offered at school. Seventy-eight children comprised two groups: children with extra physical activity (EPA; n=39; 15 females and 24 males; age: 9.2±0.8 years) and those with no involvement in extra physical activity (NPA; n=39; 21 females and 18 males; age: 9.0±0.4 years). To infer caloric expenditure, number of steps per day, and total distance traveled, children were monitored with pedometers during three nonconsecutive days: a day with a physical education class at school, a normal activity weekday, and a weekend day. Children enrolled in extra activities at school presented higher levels of caloric expenditure (EPA=132±61, NPA=61±25), performed more steps per day (EPA=7742±2473, NPA=5245±2306) and traveled longer distances (EPA=4201±1318, NPA=2799±1269), with boys (calories=154.1±91.6; steps=9763±3804; traveled distance=5114±2205) more active than girls (calories=94.4±46.7; steps=6691±2394; traveled distance=3726±1387). In the extracurricular physical activity day, children expended more calories (155.8±88.3), performed mores steps (10133±3724) and traveled longer distance (5442±2118) than in the physical education day (calories=127.2±79.3; steps=8409±3283; traveled distance=4478±1864) and in the weekend (calories=96.8±58.8; steps=6493±2687; traveled distance=3500±1466). Extracurricular physical activity at school leads to an increase of physical activity of boys and girls, even on days when the extracurricular activity is not offered. nonenrolled non Seventyeight Seventy eight groups EPA (EPA n=39 n39 n 39 1 2 males age 9208 9 0 8 9.2±0. years NPA (NPA 9004 4 9.0±0. years. . weekday EPA=132±61, EPA13261 132 61 (EPA=132±61 NPA=61±25, NPA6125 NPA=61±25 , 25 NPA=61±25) EPA=7742±2473, EPA77422473 7742 2473 (EPA=7742±2473 NPA=5245±2306 NPA52452306 5245 2306 EPA=4201±1318, EPA42011318 4201 1318 (EPA=4201±1318 NPA=2799±1269, NPA27991269 NPA=2799±1269 2799 1269 NPA=2799±1269) calories=154.1±91.6 calories1541916 154 91 6 (calories=154.1±91.6 steps=9763±3804 steps97633804 9763 3804 distance=5114±2205 distance51142205 5114 2205 calories=94.4±46.7 calories944467 94 46 7 (calories=94.4±46.7 steps=6691±2394 steps66912394 6691 2394 distance=3726±1387. distance37261387 distance=3726±1387 3726 1387 distance=3726±1387) 155.8±88.3, 1558883 155.8±88.3 155 88 3 (155.8±88.3) 10133±3724 101333724 10133 3724 (10133±3724 5442±2118 54422118 5442 2118 (5442±2118 calories=127.2±79.3 calories1272793 127 79 (calories=127.2±79.3 steps=8409±3283 steps84093283 8409 3283 distance=4478±1864 distance44781864 4478 1864 calories=96.8±58.8 calories968588 96 58 (calories=96.8±58.8 steps=6493±2687 steps64932687 6493 2687 distance=3500±1466. distance35001466 distance=3500±1466 3500 1466 distance=3500±1466) n=3 n3 920 9.2±0 900 9.0±0 EPA=132±61 EPA1326 13 (EPA=132±6 NPA612 NPA=61±2 EPA=7742±2473 EPA7742247 774 247 (EPA=7742±247 NPA=5245±230 NPA5245230 524 230 EPA=4201±1318 EPA4201131 420 131 (EPA=4201±131 NPA2799126 NPA=2799±126 279 126 calories=154.1±91. calories154191 (calories=154.1±91. steps=9763±380 steps9763380 976 380 distance=5114±220 distance5114220 511 220 calories=94.4±46. calories94446 (calories=94.4±46. steps=6691±239 steps6691239 669 239 distance3726138 distance=3726±138 372 138 155888 155.8±88. (155.8±88.3 10133±372 10133372 1013 (10133±372 5442±211 5442211 544 211 (5442±211 calories=127.2±79. calories127279 12 (calories=127.2±79. steps=8409±328 steps8409328 840 328 distance=4478±186 distance4478186 447 186 calories=96.8±58. calories96858 5 (calories=96.8±58. steps=6493±268 steps6493268 649 268 distance3500146 distance=3500±146 350 146 n= 92 9.2± 90 9.0± EPA=132±6 EPA132 (EPA=132± NPA61 NPA=61± EPA=7742±247 EPA774224 77 (EPA=7742±24 NPA=5245±23 NPA524523 52 23 EPA=4201±131 EPA420113 42 (EPA=4201±13 NPA279912 NPA=2799±12 27 calories=154.1±91 calories15419 (calories=154.1±91 steps=9763±38 steps976338 97 38 distance=5114±22 distance511422 51 22 calories=94.4±46 calories9444 (calories=94.4±46 steps=6691±23 steps669123 66 distance372613 distance=3726±13 37 15588 155.8±88 (155.8±88. 10133±37 1013337 101 (10133±37 5442±21 544221 54 (5442±21 calories=127.2±79 calories12727 (calories=127.2±79 steps=8409±32 steps840932 84 32 distance=4478±18 distance447818 44 calories=96.8±58 calories9685 (calories=96.8±58 steps=6493±26 steps649326 64 26 distance350014 distance=3500±14 35 14 9.2 9.0 EPA=132± EPA13 (EPA=132 NPA6 NPA=61 EPA=7742±24 EPA77422 (EPA=7742±2 NPA=5245±2 NPA52452 EPA=4201±13 EPA42011 (EPA=4201±1 NPA27991 NPA=2799±1 calories=154.1±9 calories1541 (calories=154.1±9 steps=9763±3 steps97633 distance=5114±2 distance51142 calories=94.4±4 calories944 (calories=94.4±4 steps=6691±2 steps66912 distance37261 distance=3726±1 1558 155.8±8 (155.8±88 10133±3 101333 10 (10133±3 5442±2 54422 (5442±2 calories=127.2±7 calories1272 (calories=127.2±7 steps=8409±3 steps84093 distance=4478±1 distance44781 calories=96.8±5 calories968 (calories=96.8±5 steps=6493±2 steps64932 distance35001 distance=3500±1 9. EPA=132 EPA1 (EPA=13 NPA=6 EPA=7742±2 EPA7742 (EPA=7742± NPA=5245± NPA5245 EPA=4201±1 EPA4201 (EPA=4201± NPA2799 NPA=2799± calories=154.1± calories154 (calories=154.1± steps=9763± steps9763 distance=5114± distance5114 calories=94.4± calories94 (calories=94.4± steps=6691± steps6691 distance3726 distance=3726± 155.8± (155.8±8 10133± (10133± 5442± (5442± calories=127.2± calories127 (calories=127.2± steps=8409± steps8409 distance=4478± distance4478 calories=96.8± calories96 (calories=96.8± steps=6493± steps6493 distance3500 distance=3500± EPA=13 (EPA=1 NPA= EPA=7742± EPA774 (EPA=7742 NPA=5245 NPA524 EPA=4201± EPA420 (EPA=4201 NPA279 NPA=2799 calories=154.1 calories15 (calories=154.1 steps=9763 steps976 distance=5114 distance511 calories=94.4 calories9 (calories=94.4 steps=6691 steps669 distance372 distance=3726 155.8 (155.8± (10133 (5442 calories=127.2 calories12 (calories=127.2 steps=8409 steps840 distance=4478 distance447 calories=96.8 (calories=96.8 steps=6493 steps649 distance350 distance=3500 EPA=1 (EPA= EPA=7742 EPA77 (EPA=774 NPA=524 NPA52 EPA=4201 EPA42 (EPA=420 NPA27 NPA=279 calories=154. calories1 (calories=154. steps=976 steps97 distance=511 distance51 calories=94. (calories=94. steps=669 steps66 distance37 distance=372 155. (155.8 (1013 (544 calories=127. (calories=127. steps=840 steps84 distance=447 distance44 calories=96. (calories=96. steps=649 steps64 distance35 distance=350 EPA= EPA=774 EPA7 (EPA=77 NPA=52 NPA5 EPA=420 EPA4 (EPA=42 NPA2 NPA=27 calories=154 (calories=154 steps=97 steps9 distance=51 distance5 calories=94 (calories=94 steps=66 steps6 distance3 distance=37 (155. (101 (54 calories=127 (calories=127 steps=84 steps8 distance=44 distance4 calories=96 (calories=96 steps=64 distance=35 EPA=77 (EPA=7 NPA=5 EPA=42 (EPA=4 NPA=2 calories=15 (calories=15 steps=9 distance=5 calories=9 (calories=9 steps=6 distance=3 (155 (10 (5 calories=12 (calories=12 steps=8 distance=4 EPA=7 EPA=4 calories=1 (calories=1 steps= distance= calories= (calories= (15 (1 ( (calories
RESUMO O objetivo deste estudo foi verificar e comparar a prática de atividade física de crianças em diferentes dias da semana envolvidas e não envolvidas em um programa de atividade física extracurricular. Setenta e oito crianças formaram dois grupos: crianças com atividade física extracurricular (CAF; n=39; 15 meninas e 24 meninos; idade: 9,2±0,8 anos) e crianças sem atividade física extracurricular (NAF; n=39; 21 meninas e 18 meninos; idade: 9,0±0,4 anos). Foram estimados o dispêndio calórico, o número de passos por dia e a distância percorrida, por meio de pedômetros em dias não consecutivos: um dia com aula de educação física, um dia com atividades cotidianas e um dia de final de semana. Crianças envolvidas em atividades extracurriculares na escola apresentaram maior dispêndio calórico (CAF=132±61, NAF=61±25), número de passos (CAF=7742±2473, NAF=5245±2306) e distância percorrida (CAF=4201±1318, NAF=2799±1269), sendo ainda meninos (calorias=154,1±91,6; passos=9763±3804; distância=5114±2205) mais ativos que meninas (calorias=94,4±46,7; passos=6691±2394; distância=3726±1387). No dia de atividade extracurricular, crianças dispendem mais calorias (155,8±88,3), realizam mais passos (10133±3724) e percorrem maior distância (5442±2118) do que nos dias de educação física (calorias=127,2±79,3; passos=8409±3283; distância=4478±1864) e final de semana (calorias=96,8±58,8; passos=6493±2687; distância=3500±1466). Atividade física extracurricular na escola promove aumento de atividade física de meninos e meninas, mesmo nos dias em que a atividade física extracurricular não foi oferecida. grupos CAF (CAF n=39 n39 n 39 1 2 idade 9208 9 0 8 9,2±0, anos NAF (NAF 9004 4 9,0±0, anos. . consecutivos CAF=132±61, CAF13261 132 61 (CAF=132±61 NAF=61±25, NAF6125 NAF=61±25 , 25 NAF=61±25) CAF=7742±2473, CAF77422473 7742 2473 (CAF=7742±2473 NAF=5245±2306 NAF52452306 5245 2306 CAF=4201±1318, CAF42011318 4201 1318 (CAF=4201±1318 NAF=2799±1269, NAF27991269 NAF=2799±1269 2799 1269 NAF=2799±1269) calorias=154,1±91,6 calorias1541916 154 91 6 (calorias=154,1±91,6 passos=9763±3804 passos97633804 9763 3804 distância=5114±2205 distância51142205 5114 2205 calorias=94,4±46,7 calorias944467 94 46 7 (calorias=94,4±46,7 passos=6691±2394 passos66912394 6691 2394 distância=3726±1387. distância37261387 distância=3726±1387 3726 1387 distância=3726±1387) 155,8±88,3, 1558883 155,8±88,3 155 88 3 (155,8±88,3) 10133±3724 101333724 10133 3724 (10133±3724 5442±2118 54422118 5442 2118 (5442±2118 calorias=127,2±79,3 calorias1272793 127 79 (calorias=127,2±79,3 passos=8409±3283 passos84093283 8409 3283 distância=4478±1864 distância44781864 4478 1864 calorias=96,8±58,8 calorias968588 96 58 (calorias=96,8±58,8 passos=6493±2687 passos64932687 6493 2687 distância=3500±1466. distância35001466 distância=3500±1466 3500 1466 distância=3500±1466) oferecida n=3 n3 920 9,2±0 900 9,0±0 CAF=132±61 CAF1326 13 (CAF=132±6 NAF612 NAF=61±2 CAF=7742±2473 CAF7742247 774 247 (CAF=7742±247 NAF=5245±230 NAF5245230 524 230 CAF=4201±1318 CAF4201131 420 131 (CAF=4201±131 NAF2799126 NAF=2799±126 279 126 calorias=154,1±91, calorias154191 (calorias=154,1±91, passos=9763±380 passos9763380 976 380 distância=5114±220 distância5114220 511 220 calorias=94,4±46, calorias94446 (calorias=94,4±46, passos=6691±239 passos6691239 669 239 distância3726138 distância=3726±138 372 138 155888 155,8±88, (155,8±88,3 10133±372 10133372 1013 (10133±372 5442±211 5442211 544 211 (5442±211 calorias=127,2±79, calorias127279 12 (calorias=127,2±79, passos=8409±328 passos8409328 840 328 distância=4478±186 distância4478186 447 186 calorias=96,8±58, calorias96858 5 (calorias=96,8±58, passos=6493±268 passos6493268 649 268 distância3500146 distância=3500±146 350 146 n= 92 9,2± 90 9,0± CAF=132±6 CAF132 (CAF=132± NAF61 NAF=61± CAF=7742±247 CAF774224 77 (CAF=7742±24 NAF=5245±23 NAF524523 52 23 CAF=4201±131 CAF420113 42 (CAF=4201±13 NAF279912 NAF=2799±12 27 calorias=154,1±91 calorias15419 (calorias=154,1±91 passos=9763±38 passos976338 97 38 distância=5114±22 distância511422 51 22 calorias=94,4±46 calorias9444 (calorias=94,4±46 passos=6691±23 passos669123 66 distância372613 distância=3726±13 37 15588 155,8±88 (155,8±88, 10133±37 1013337 101 (10133±37 5442±21 544221 54 (5442±21 calorias=127,2±79 calorias12727 (calorias=127,2±79 passos=8409±32 passos840932 84 32 distância=4478±18 distância447818 44 calorias=96,8±58 calorias9685 (calorias=96,8±58 passos=6493±26 passos649326 64 26 distância350014 distância=3500±14 35 14 9,2 9,0 CAF=132± CAF13 (CAF=132 NAF6 NAF=61 CAF=7742±24 CAF77422 (CAF=7742±2 NAF=5245±2 NAF52452 CAF=4201±13 CAF42011 (CAF=4201±1 NAF27991 NAF=2799±1 calorias=154,1±9 calorias1541 (calorias=154,1±9 passos=9763±3 passos97633 distância=5114±2 distância51142 calorias=94,4±4 calorias944 (calorias=94,4±4 passos=6691±2 passos66912 distância37261 distância=3726±1 1558 155,8±8 (155,8±88 10133±3 101333 10 (10133±3 5442±2 54422 (5442±2 calorias=127,2±7 calorias1272 (calorias=127,2±7 passos=8409±3 passos84093 distância=4478±1 distância44781 calorias=96,8±5 calorias968 (calorias=96,8±5 passos=6493±2 passos64932 distância35001 distância=3500±1 9, CAF=132 CAF1 (CAF=13 NAF=6 CAF=7742±2 CAF7742 (CAF=7742± NAF=5245± NAF5245 CAF=4201±1 CAF4201 (CAF=4201± NAF2799 NAF=2799± calorias=154,1± calorias154 (calorias=154,1± passos=9763± passos9763 distância=5114± distância5114 calorias=94,4± calorias94 (calorias=94,4± passos=6691± passos6691 distância3726 distância=3726± 155,8± (155,8±8 10133± (10133± 5442± (5442± calorias=127,2± calorias127 (calorias=127,2± passos=8409± passos8409 distância=4478± distância4478 calorias=96,8± calorias96 (calorias=96,8± passos=6493± passos6493 distância3500 distância=3500± CAF=13 (CAF=1 NAF= CAF=7742± CAF774 (CAF=7742 NAF=5245 NAF524 CAF=4201± CAF420 (CAF=4201 NAF279 NAF=2799 calorias=154,1 calorias15 (calorias=154,1 passos=9763 passos976 distância=5114 distância511 calorias=94,4 calorias9 (calorias=94,4 passos=6691 passos669 distância372 distância=3726 155,8 (155,8± (10133 (5442 calorias=127,2 calorias12 (calorias=127,2 passos=8409 passos840 distância=4478 distância447 calorias=96,8 (calorias=96,8 passos=6493 passos649 distância350 distância=3500 CAF=1 (CAF= CAF=7742 CAF77 (CAF=774 NAF=524 NAF52 CAF=4201 CAF42 (CAF=420 NAF27 NAF=279 calorias=154, calorias1 (calorias=154, passos=976 passos97 distância=511 distância51 calorias=94, (calorias=94, passos=669 passos66 distância37 distância=372 155, (155,8 (1013 (544 calorias=127, (calorias=127, passos=840 passos84 distância=447 distância44 calorias=96, (calorias=96, passos=649 passos64 distância35 distância=350 CAF= CAF=774 CAF7 (CAF=77 NAF=52 NAF5 CAF=420 CAF4 (CAF=42 NAF2 NAF=27 calorias=154 (calorias=154 passos=97 passos9 distância=51 distância5 calorias=94 (calorias=94 passos=66 passos6 distância3 distância=37 (155, (101 (54 calorias=127 (calorias=127 passos=84 passos8 distância=44 distância4 calorias=96 (calorias=96 passos=64 distância=35 CAF=77 (CAF=7 NAF=5 CAF=42 (CAF=4 NAF=2 calorias=15 (calorias=15 passos=9 distância=5 calorias=9 (calorias=9 passos=6 distância=3 (155 (10 (5 calorias=12 (calorias=12 passos=8 distância=4 CAF=7 CAF=4 calorias=1 (calorias=1 passos= distância= calorias= (calorias= (15 (1 ( (calorias
7.
Meningoencephalitis secondary to rhinitis caused by Pythium insidiosum in sheep
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Firmino, Millena de Oliveira
; Leite, Ialys Macêdo
; Sousa, Davi Emanuel Ribeiro de
; Maia, Lisanka Ângelo
; Simões, Sara Vilar Dantas
; Kommers, Glaucia Denise
; Galiza, Glauco José Nogueira de
; Dantas, Antônio Flávio Medeiros
.
RESUMO: Relata-se um caso de meningoencefalite por Pythium insidiosum secundária a rinite em uma ovelha mestiça, três anos de idade, proveniente de um rebanho de 15 animais, criados extensivamente e com acesso livre a açude. O animal apresentava dispneia leve, cegueira, midríase, opistótono, nistagmo, incoordenação, diminuição do tônus mandibular e espasticidade dos membros pélvicos. O exame macroscópico da cavidade nasal evidenciou uma massa vermelho-escura, irregular, friável, que comprometia bilateralmente o septo nasal e a porção rostral dos cornetos nasais. No encéfalo, havia espessamento difuso das leptomeninges do cerebelo e porção ventral do tronco encefálico caracterizado por material granular amarelado associado à hiperemia dos vasos. No assoalho do quarto ventrículo, havia deposição de material amarelado, irregular, levemente granuloso, que se projetava em direção ao óbex e deslocava o cerebelo dorsolateralmente. Microscopicamente, havia rinite piogranulomatosa, eosinofílica, necrosante e meningoencefalite fibrinossupurativa, eosinofílica, necrosante, ambas associadas à trombose, vasculite e hifas intralesionais. Pela utilização da técnica de GMS as hifas foram impregnadas pela prata e apresentavam paredes finas e paralelas, raramente septadas e ramificadas. Na imuno-histoquímica, houve imunomarcação com o anticorpo policlonal anti-P. insidiosum em fragmentos do cerebelo e cavidade nasal. Os achados evidenciaram que rinite por P. insidiosum pode afetar secundariamente o sistema nervoso de ovinos, causando sinais clínicos neurológicos inespecíficos.
ABSTRACT: A case of meningoencephalitis caused by Pythium insidiosum secondary to rhinitis is reported in a three-year-old crossbred sheep from a herd of 15 animals, raised extensively and with free access to a weir. The animal presented mild dyspnea, blindness, mydriasis, opisthotonos, nystagmus, incoordination, decreased mandibular tone, and spasticity of the pelvic limbs. Macroscopic examination of the nasal cavity showed a blackish-red, irregular, friable mass that bilaterally compromised the nasal septum and the rostral portion of the nasal turbinates. In the brain, there was diffuse thickening of the leptomeninges of the cerebellum and ventral portion of the brainstem characterized by yellowish, granular material associated with vessel hyperemia. On the floor of the fourth ventricle, there was deposition of yellowish, irregular, slightly granular material that protruded towards the obex and displaced the cerebellum dorsolaterally. Microscopically, there were pyogranulomatous, eosinophilic, necrotizing rhinitis and fibrinosuppurative, eosinophilic, necrotizing meningoencephalitis, both associated with thrombosis, vasculitis, and intralesional hyphae. The hyphae were impregnated with silver and presented thin, parallel walls, rarely septate and branched. At immunohistochemistry, the hyphae were immunostained with polyclonal anti-P. insidiosum antibody in fragments of the cerebellum and nasal cavity. The findings showed that P. insidiosum rhinitis can secondarily affect the nervous system of sheep, causing nonspecific neurological clinical signs.
8.
A potência do SUS no enfrentamento à Covid-19: alocação de recursos e ações nos municípios brasileiros
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Resumo Neste artigo, objetivou-se analisar a forma como os governos municipais responderam à crise sanitária e quais medidas desenvolveram em termos de diagnóstico da Covid-19 e alocação dos recursos provenientes de fontes federais. Para tanto, informações oriundas de uma pesquisa com 4.061 prefeitos coordenada pela Confederação Nacional dos Municípios foram sistematizadas e comparadas com outras bases de dados oficiais. Conclui-se que, a despeito da falta de instrumentos de coordenação desenvolvidos em âmbito federal, a destinação dos recursos e o desenvolvimento de políticas por parte dos municípios se orientaram pela concentração de serviços de referência regional em municípios de grande e médio portes.
Abstract This article aimed to analyze how municipal governments responded to the health crisis and what measures they developed in terms of diagnosing Covid-19 and allocating resources from Brazil’s federal sources. To this end, information from a survey with 4,061 mayors coordinated by the National Confederation of Municipalities was systematized and compared with other official databases. We concluded that, despite the lack of coordination instruments developed at the federal level, the allocation of resources and the development of policies by the municipalities were guided by the concentration of regional reference services in large and medium-sized municipalities.
Resumen El trabajo tiene como objetivo analizar cómo los gobiernos municipales respondieron a la crisis sanitaria, qué medidas desarrollaron en términos de diagnóstico de Covid-19 y cómo asignaron los recursos transferidos desde el gobierno federal de Brasil. Para ello, se sistematizó la información de una encuesta coordinada por la Confederación Nacional de Municipios y se comparó con otras bases de datos oficiales. En cuanto a la conclusión, se argumenta que, a pesar de la falta de instrumentos de coordinación desarrollados a nivel federal, la asignación de recursos y el desarrollo de políticas por parte de los municipios estuvieron orientados por la concentración de los servicios regionales de referencia en los municipios grandes y medianos.
9.
Relation between red blood cell distribution width and acute kidney injury in patients with sepsis
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Ramires, Marina Larissa Vettorello
; Leite, Manoela Fidelis Batista
; Lo, Daniel Zu Yow
; Silveira, Leonardo Bonilla da
; Ferraz, Leonardo José Rolim
; Pardini, Andreia
; Sakashita, Araci Massami
; Kondo, Andrea Tiemi
; Olivato, Guilherme Benfatti
; Durão Junior, Marcelino de Souza
; Rodrigues, Adelson Marçal
; Chiloff, Daniela Mendes
; Almeida, Danilo Candido de
; Goes, Miguel Angelo
.
ABSTRACT Objective The objective of the present study is to evaluate the association of red blood cell distribution width with acute kidney injury in sepsis. Methods This is a retrospective study of 849 critically ill patients with sepsis in intensive care unit. Demographic data, renal function, inflammation, complete blood count, and acid-base parameters were compared between acute kidney injury and non-acute kidney injury groups. Therefore, a multivariate analysis was performed to observe independent predictive factors. Results Comparatively, higher levels of C-reactive protein, lactate, red blood cell distribution width, and Simplified Acute Physiology Score 3 were found in the acute kidney injury group. The study showed a higher frequency of women, hemoglobin (Hgb) concentration, platelets, bicarbonate and PaO2/FiO2 ratio in the non-acute kidney injury group. In addition, there was an independent association of comorbidity-chronic kidney disease [OR 3.549, 95%CI: 1.627-7.743; p<0.001], urea [OR 1.047, 95%CI: 1.036-1.058; p<0.001] and RDW [OR 1.158, 95%CI: 1.045-1.283; p=0.005] with acute kidney injury in sepsis patients. Conclusion As an elective risk factor, red blood cell distribution width was independently associated with sepsis-related acute kidney injury. Thus, red blood cell distribution width acts like a predictive factor for sepsis-induced acute kidney injury in intensive care unit admission.
10.
Professor Ângelo Machado: career, scientific contributions, and the iconic neuroanatomy book
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MEIRA, Alex Tiburtino
; FRANKLIN, Gustavo Leite
; CARDOSO, Francisco
; TEIVE, Hélio Afonso Ghizoni
; BARSOTTINI, Orlando Graziani Povoas
; PEDROSO, José Luiz
.
RESUMO O professor Ângelo Barbosa Monteiro Machado (22/05/1934-06/04/2020) foi um dos mais destacados e respeitados professores da história do Brasil. Ele trabalhou amplamente como professor, neurocientista, escritor, dramaturgo e entomologista. A publicação do livro de neuroanatomia é pioneira, revolucionária e icônica na história da educação médica acadêmica no Brasil. No campo da literatura, também escreveu diversos livros nos quais adaptou o conhecimento científico para as crianças. Neste artigo, os autores abordam a vida acadêmica do professor Ângelo Machado e as etapas que culminaram no mais conceituado livro brasileiro de neuroanatomia: Neuroanatomia Funcional.
ABSTRACT Professor Ângelo Barbosa Monteiro Machado (May 22, 1934 to April 6, 2020) was one of the most outstanding and respected professors in the Brazilian history. He worked broadly as a professor, neuroscientist, writer, dramaturgist, neurobiologist, and entomologist. The publication of the neuroanatomy book is pioneer, revolutionary, and iconic in the history of academic medical education in Brazil. In the literature field, he also wrote many books in which he adapted scientific knowledge to children. In this article, the authors approach the academic life of Professor Ângelo Machado and the steps that culminated in the most renowned Brazilian textbook of neuroanatomy: Neuroanatomia Funcional.
https://doi.org/10.1590/0004-282x-anp-2021-0172
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11.
[SciELO Preprints] - The COVID-19 pandemic and plans for economic reopening in Brazil: a documental analysis
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Melo Sousa, Brenda Caroline
Pereira de Paiva, Miguel Henrique
Alencar Miranda Filho, Valberto
Leite Sousa Campelo, Eloina Hadigyna
Alves Franco Bravin, Andressa
Sobrinho Silva, Maria Yanaelle
Brito Rodrigues, Ângelo
Tajra, Fábio Solon
Guedes Alcoforado Aguiar, Bruno
Resumo:
En
BACKGROUND: In March 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic. In Brazil, the high rate of dissemination made it necessary to adopt restrictive measures nationwide with the discussion regarding the resumption of economic activities starting in April. In mid-December the country had 6,970,034 cases diagnosed and 182,799 deaths from COVID-19.
OBJECTIVE: To analyze the content and characteristics of official documents, which guided the period of transition and resumption of economic activities in Brazil based on health indicators. METHODS: This is a documental research, carried out between May and July 2020, using official websites and publications from the state governments of the 27 federative units in Brazil as sources. In the study, only documents that used epidemiological and health indicators were included as determining criteria for decision making in relation to the easing, permanence or regression of social isolation measures adopted during the COVID-19 pandemic.
FINDINGS: Plans, decrees and technical notes were identified for 18 Brazilian federal units. In most documents, the scientific team was made up exclusively of technicians (n = 10). The number of indicators found ranged from 2 to 11, being stratified into 5 categories: frequency and distribution of the disease; social and collective adherence; installed capacity or service profile; productive potential; and availability of supplies.
MAIN CONCLUSIONS: Knowing governmental strategies, adopted in the easing of restrictive measures, in the face of the coronavirus (SARS-CoV-2) pandemic based on indicators and with the possibility of comparison between different federative units, provides subsidies for understanding the outcome of the disease by place of occurrence, allowing the construction of a panorama pathology in the country. The appropriation of the findings of this study by Brazil and other countries also serves as an instrument for reflection and planning of policies adopted during the COVID-19 pandemic.
12.
Dietary supplementation with multi-strain formula of probiotics modulates inflammatory and immunological markers in apical periodontitis
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COSME-SILVA, Leopoldo
; DAL-FABBRO, Renan
; CINTRA, Luciano Tavares Angelo
; ERVOLINO, Edilson
; PRADO, Alana Sant’Ana do
; OLIVEIRA, Daniel Pinto de
; MARCELOS, Priscylla Gonçalves Correia Leite de
; GOMES-FILHO, João Eduardo
.
Abstract Objective The aim of this study was to evaluate whether probiotics multi-strain formula affects the development of apical periodontitis (AP) induced in rats. Methodology 16 Wistar rats were divided in two groups (n=8): rats with AP fed with regular diet (Control-C (CG)); rats with AP, fed with regular diet and supplemented with multi-strain formula (one billion colony-forming units (CFU)): GNC Probiotic Complex (PCG) ( Lactobacillus acidophilus, Lactobacillus salivaris, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium bifidum, Bifidobacterium animalis subs. lactis and Streptococcus thermofilus ). AP was induced in the upper and lower first molars by dental pulp exposure to the oral environment. PCG was administered orally through gavage for 30 days during the AP development. After this period the animals were euthanized and the mandibles were removed and processed for histologic analysis, and immunochemical assays for interleukin (IL)-6, IL-10, IL-1β, RANKL, OPG, and TRAP. The Mann–Whitney U test and Student’s t test were performed (P<.05). Results The CG showed more intense inflammatory infiltrate than the PCG group (P<.05). IL-1β, IL 6 and RANKL decreased in the PCG group compared with CG (P<.05). The IL-10 level increased in the PCG group (P<.05). The OPG level was similar in both groups (P>.05). The number of mature osteoclasts (TRAP-positive multinucleated cells) was lower in PCG group when compared to the CG (P<.05). Conclusion Probiotic Complex modulates inflammation and bone resorption in apical periodontitis.
https://doi.org/10.1590/1678-7757-2020-0483
1001 downloads
13.
STRUCTURAL ANALYSIS OF THE SOCIAL REPRESENTATIONS ON COVID-19 AMONG ASSISTANCE NURSES
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Coelho, Manuela de Mendonça Figueirêdo
; Cavalcante, Viviane Mamede Vasconcelos
; Cabral, Riksberg Leite
; Oliveira, Roberta Meneses
; Araújo, Michell Ângelo Marques
; Gomes, Antônio Marcos Tosoli
.
RESUMO Objetivo analisar a estrutura das representações sociais sobre a Covid-19 entre enfermeiros assistenciais. Método estudo qualitativo fundamentado na Teoria das Representações Sociais, com análise estrutural, realizado com 178 enfermeiros do Ceará, Brasil, no período de maio a junho de 2020. As evocações foram tratadas pelo software EVOC 2000 originando o quadro de quatro casas. Utilizou-se o IRAMUTEQ para produzir a árvore de similitudes. Resultados o possível núcleo central foi constituído pelos elementos “medo” e “isolamento”, com a “morte” constituindo a primeira periferia; “tristeza”, “dor” e “insegurança”, na segunda periferia; e “dispneia”, “angústia” e “pandemia”, na zona de contraste. Conclusão no primeiro momento, as representações foram construídas em torno de emoções e sentimentos negativos. Indicam-se novos estudos, com adoção de outros métodos de análise para confronto dos achados.
ABSTRACT Objective to analyze the structure of the social representations on Covid-19 among assistance nurses. Method a study with a qualitative approach, based on the Theory of Social Representations, with structural analysis, conducted with 178 nurses from Ceará, Brazil, from May to June 2020. The evocations were processed with the EVOC 2000® software, creating the four-house chart. IRAMUTEQ® was used to produce the similarity tree. Results the potential central nucleus was composed of “fear” and “isolation”, with “death” constituting the first periphery; “sadness”, “pain”, and “uncertainty” in the second periphery; and “dyspnea”, “anguish”, and “pandemic”, in the contrast zone. Conclusion at the first moment, the representations were constructed around negative feelings and emotions. New studies are indicated, with the adoption of other analysis methods to confront the findings.
RESUMEN Objetivo analizar la estructura de las representaciones sociales sobre Covid-19 entre enfermeros asistenciales. Método estudio de enfoque cualitativo, fundamentado en la Teoría de las Representaciones Sociales, con análisis estructural, realizado con 178 enfermeros de Ceará, Brasil, entre mayo y junio de 2020. Las evocaciones se sometieron a tratamiento en el software EVOC 2000® dando origen al cuadro de las cuatro casas. Se utilizó el IRAMUTEQ® para generar el árbol de similitud. Resultados el posible núcleo central estuvo constituido por los siguientes elementos: “miedo” y “aislamiento”, con la “muerte” constituyendo la primera periferia; “tristeza”, “dolor” e “inseguridad”, en la segunda periferia; y “disnea”, “angustia” y “pandemia”, en la zona de contraste. Conclusión en el primer momento, las representaciones se construyeron en torno a emociones y sentimientos negativos. Se indican nuevos estudios, con la adopción de otros métodos de análisis para confrontar los hallazgos.
https://doi.org/10.1590/1980-265x-tce-2020-0358
760 downloads
14.
New sensitive real-time PCR targeting p28 gene for detection of Ehrlichia canis in blood samples from dogs
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Paulino, Patrícia Gonzaga
; Camilo, Tays Araujo
; Mota Junior, Miguel Angelo Leite
; Senne, Nathália Alves de
; Ramirez, Olga Lucia Herrán
; Costa, Renata Lins da
; Massard, Carlos Luiz
; Santos, Huarrisson Azevedo
.
RESUMO: Este estudo tem como objetivo descrever um novo método de detecção de uma reação em cadeia da polimerase quantitativa em tempo real (qPCR) visando o gene da proteína da membrana externa de 28 kDa (p28), bem como comparar este método com um PCR convencional (cPCR), que visa o mesmo gene, a fim de avaliar o desempenho da técnica desenhada neste estudo na detecção de Ehrlichia canis (E. canis). As concentrações ideais de oligonucleotídeos foram alcançadas e a sensibilidade analítica e a especificidade do qPCR foram determinadas. Um total de 218 amostras de sangue total de cães foram coletadas convencionalmente para este estudo. O DNA foi extraído de cada amostra. Posteriormente, as amostras foram testadas por um cPCR estabelecido e o novo qPCR para comparar os desempenhos entre cada técnica. A curva padrão revelou 100% de eficiência e coeficiente de determinação (R2) equivalente a 99,8%. Dentre as amostras examinadas por qPCR, 24,31% foram consideradas positivas, percentual significativamente maior do que as detectadas por cPCR (15,13%). A técnica qPCR atingiu uma sensibilidade maior do que a cPCR na detecção de E. canis. A qPCR padronizada neste estudo é um método eficiente para a confirmação do diagnóstico de erliquiose monocítica canina (EMC) e pode fornecer o monitoramento de níveis de parasitemia ao longo do tratamento da doença.
ABSTRACT: This study aims to describe a new detection method of a quantitative real-time polymerase chain reaction (qPCR) targeting the 28 kDa outer membrane protein gene (p28) as well as to compare this method with a conventional PCR (cPCR), which targets the same gene, in order to evaluate the performance of the technique designed in this study in detecting Ehrlichia canis (E. canis). Optimum oligonucleotides concentrations were reached, and the analytical sensitivity and specificity of the qPCR were performed. A total of 218 dogs’ whole blood samples were conventionally collected for this study. The DNA was extracted from each sample. Subsequently, the samples were tested by an established cPCR and the new qPCR to compare each technique’s performances. This new qPCR method for the molecular detection of E. canis presented a detection limit of ten copies of the fragment and was considered specific for E. canis according to analytical specificity analyses performed in vitro and in silico. The standard curve revealed 100% efficiency and a coefficient of determination (R2) equivalent to 99.8%. Among the samples examined by qPCR, 24.31% were considered positive, significantly greater than those detected by cPCR (15.13%). The qPCR technique reached a higher sensitivity than the cPCR when targeting the p28 gene in detecting E. canis. The qPCR standardized in this study is an efficient method for confirming canine monocytic ehrlichiosis (CME) diagnosis and might provide the parasitemia monitoring during the disease treatment.
https://doi.org/10.1590/0103-8478cr20200891
143 downloads
15.
Synthesis of a chitosan nanoparticle suspension and its protective effects against enamel demineralization after an in vitro cariogenic challenge
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MAGALHÃES, Taís Chaves
; TEIXEIRA, Natália Moreira
; FRANÇA, Renata Sobreira
; DENADAI, Ângelo Márcio Leite
; SANTOS, Rogério Lacerda dos
; CARLO, Hugo Lemes
; MUNCHOW, Eliseu Aldrighi
; CARVALHO, Fabíola Galbiatti de
.
Abstract Objective Our study aims to synthesize, characterize, and determine the effects of a ChNPs suspension on human enamel after cariogenic challenge via pH-cycling. Methodology ChNPs were synthesized by ion gelation and characterized by Transmission Electron Microscopy (TEM) and Dynamic Light Scattering. Forty enamel blocks were divided into four groups (n=10/group): (i) ChNPs suspension; (ii) chitosan solution; (iii) 0.05% sodium fluoride (NaF) solution; and (iv) distilled water. Specimens were exposed to cariogenic challenge by cycling in demineralization solution (3 h) and then remineralized (21h) for 7 days. Before each demineralization cycle, the corresponding solutions were passively applied for 90 s. After 7 days, specimens were examined for surface roughness (Ra) and Knoop hardness (KHN) before and after the cariogenic challenge; % KHN change (variation between initial and final hardness), and surface topography by an optical profilometer. The data were analyzed by repeated-measures ANOVA, One-way ANOVA, and Tukey tests (α=0.05). Results TEM images showed small spherical particles with diameter and zeta potential values of 79.3 nm and +47.9 mV, respectively. After the challenge, all groups showed an increase in Ra and a decrease in KHN values. Optical profilometry indicated that ChNPs- and NaF-treated specimens showed uneven roughness interspersed with smooth areas and the lowest %KHN values. Conclusion The ChNPs suspension was successfully synthesized and minimized human enamel demineralization after a cariogenic challenge, showing an interesting potential for use as an oral formulation for caries prevention.
https://doi.org/10.1590/1678-7757-2021-0120
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Você pode enriquecer sua busca de uma forma muito simples. Use os índices de pesquisa combinados com os conectores (AND ou OR) e especifique cada vez mais sua busca.
Por exemplo, se você deseja buscar artigos sobre
casos de dengue no Brasil em 2015, use:ti:dengue and publication_year:2015 and aff_country:Brasil
Veja abaixo a lista completa de índices de pesquisa que podem ser usados:
Cód. do Índice | Elemento |
---|---|
ti | título do artigo |
au | autor |
kw | palavras-chave do artigo |
subject | assunto (palavras do título, resumo e palavras-chave) |
ab | resumo |
ta | título abreviado da revista (ex. Cad. Saúde Pública) |
journal_title | título completo da revista (ex. Cadernos de Saúde Pública) |
la | código do idioma da publicação (ex. pt - Português, es - Espanhol) |
type | tipo do documento |
pid | identificador da publicação |
publication_year | ano de publicação do artigo |
sponsor | financiador |
aff_country | código do país de afiliação do autor |
aff_institution | instituição de afiliação do autor |
volume | volume do artigo |
issue | número do artigo |
elocation | elocation |
doi | número DOI |
issn | ISSN da revista |
in | código da coleção SciELO (ex. scl - Brasil, col - Colômbia) |
use_license | código da licença de uso do artigo |