Abstract Background The perception of family support in chronic disease can be relevant. Objective To assess the perception of family support in adult patients with epilepsy (PWEs) and relate it to quality of life (QoL) and clinical aspects. Methods Data from the Perceived Family Support Inventory (IPFS) of 130 PWEs were related to the clinical variables, QOLIE-31 scores, and the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) with statistical tests, with p < 0.05. Results The mean age was 49.9 ± 17.2 years, and the duration of epilepsy was 20.8 ± 15.4 years. The presence of depression (scores ≥ 15) was associated with lower family support. Being married and non-occurrence of depression were the variables associated with a higher IPFS score (R = 0.2112), in the multiple linear regression. Conclusion The perception of greater family support was associated with demographic aspects, the absence of depression, and better QoL. Family relationships may play an essential role in health adjustment behaviors and QoL in epilepsy. relevant (PWEs (QoL aspects (IPFS 13 QOLIE31 QOLIE 31 QOLIE-3 scores NDDIE NDDI E (NDDI-E tests 005 0 05 0.05 499 49 9 49. 172 17 2 17. years 208 20 8 20. 154 15 4 15. nonoccurrence non occurrence R 0.2112, 02112 0.2112 , 2112 0.2112) regression 1 QOLIE3 3 QOLIE- 00 0.0 0211 0.211 211 0. 021 0.21 21 02 0.2

Resumo Antecedentes A percepção do suporte familiar nas doenças crônicas pode ser relevante. Objetivo Avaliar em pacientes adultos com epilepsia (PCE) a percepção do suporte familiar e relacioná-la com os aspectos clínicos e com a qualidade de vida (QV). Métodos Os dados do Inventário de Percepção de Suporte Familiar (IPSF) de 130 PCE foram relacionados com as variáveis clínicas, os escores do QOLIE-31 e com o Neurological Disorders Depression Inventory for Epilepsy (NDDI-E), com testes estatísticos, com p < 0.05. Resultados A idade média foi 49.9 ± 17.2 anos e o tempo de epilepsia foi de 20.8 ± 15.4 anos. Escores ≥ 15 no NDDI-E (presença de depressão) associaram-se a menor suporte familiar. Ser casado e não ter depressão são as variáveis associadas a maiores escores no IPSF (R = 0.2112), na regressão linear múltipla. Conclusão A percepção de maior suporte familiar associou-se à aspectos demográficos, a ausência de depressão e a melhor QV. As relações familiares podem ter papel essencial nos comportamentos de ajustamento na saúde e na QV na epilepsia. relevante (PCE relacionála relacioná la . (QV) (IPSF 13 clínicas QOLIE31 QOLIE 31 QOLIE-3 NDDIE, NDDIE NDDI E , (NDDI-E) estatísticos 005 0 05 0.05 499 49 9 49. 172 17 2 17. 208 20 8 20. 154 4 15. 1 presença associaramse associaram se R 0.2112, 02112 0.2112 2112 0.2112) múltipla associouse associou demográficos (QV QOLIE3 3 QOLIE- (NDDI-E 00 0.0 0211 0.211 211 0. 021 0.21 21 02 0.2

Abstract Objective: to assess the occurrence of overweight/obesity in patient with epilepsy (PWEs) and to relate it to cognitive aspects and clinical variables. Methodology: the measurements of waist circumference, calf circumference, arm circumference, and the body mass index were related to the scores of the Mini-Mental State Examination and the Brief Cognitive Battery-Edu, as well as to the clinical variables of 164 PWEs, with a significance level of p < 0.05. Data were compared to a similar control group (CG) comprising 71 cases. Linear and multiple logistic regression models were used to assess factors related to cognitive aspects. Results: the mean age of the PWEs was 49.8 ± 16.6 years with a mean length of epilepsy of 22 ± 15.9 years. Overweight/obesity occurred in 106 (64.6 %) PWEs and in 42 (59.1 %) CG subjects. The PWEs had a worse performance in several cognitive functions when compared to CG subjects. In the PWEs, overweight/obesity was associated with lower educational level, older age, and cognitive impairment. Greater waist circumference, overweight, age at the first seizure, and use of polytherapy with antiseizure medications were predictive factors of memory impairment in multiple linear regression. Greater arm and calf circumference values were associated with better performance in several cognitive areas. Conclusion: the occurrence of overweight/obesity in PWEs and CG subjects was high. Cognitive impairment occurred in a high number of PWEs and was associated with overweight, greater waist circumference values, and clinical aspects of epilepsy. Better cognitive performance was associated with greater arm and calf circumference.

Resumen Objetivo: evaluar la ocurrencia de sobrepeso/obesidad en pacientes con epilepsia y relacionarla con aspectos cognitivos y variables clínicas. Metodología: las medidas de circunferencia de cintura, circunferencia de pantorrilla, circunferencia de brazo e índice de masa corporal se relacionaron con los puntajes del Mini-Mental State Exam y de la Batería Cognitiva Breve-Edu, así como con las variables clínicas de 164 pacientes con epilepsia, con un nivel de significación de p < 0,05. Los datos se compararon con un grupo de control similar (GC) compuesto por 71 casos. Se utilizaron modelos de regresión logística lineal y múltiple para evaluar factores relacionados con aspectos cognitivos. Resultados: la edad media de las pacientes con epilepsia fue de 49,8 ± 16,6 años con una duración media de la epilepsia de 22 ± 15,9 años. Presentaron sobrepeso/obesidad 106 (64,6 %) pacientes con epilepsia y 42 (59,1 %) sujetos del GC. Los pacientes con epilepsia tuvieron un peor desempeño en varias funciones cognitivas en comparación con los sujetos del GC. En las pacientes con epilepsia, el sobrepeso/obesidad se asoció con menor nivel educativo, mayor edad y deterioro cognitivo. La mayor circunferencia de la cintura, el sobrepeso, la edad de la primera convulsión y el uso de politerapia con medicamentos anticonvulsivos fueron factores predictivos del deterioro de la memoria en la regresión lineal múltiple. Los valores mayores de circunferencia del brazo y la pantorrilla se asociaron con un mejor rendimiento en varias áreas cognitivas. Conclusión: la incidencia de sobrepeso/obesidad en sujetos pacientes con epilepsia y GC fue alta. El deterioro cognitivo ocurrió en un alto número de pacientes con epilepsia y se asoció con sobrepeso, mayores valores de circunferencia de la cintura y aspectos clínicos de la epilepsia. Un mejor rendimiento cognitivo se asoció con una mayor circunferencia del brazo y la pantorrilla.

ABSTRACT Background: Several mechanisms, including excessive hunger, account for patients’ difficulties in maintaining weight loss and dietary changes after caloric restriction. Objective: To evaluate the effect of short-term high-fiber calorie-restricted diet in appetite-regulating hormones, and hunger and satiety sensations in women with obesity. Methds: In a randomized controlled trial study, thirty women with body mass index (BMI) higher than 30 kg/m2, and aged from 20 to 50 years were hospitalized following a calorie-restricted diet (1000 kcal/day) for three days. The experimental group (n=15) received high-fiber diet and the control group (n=15), conventional diet. Body weight, BMI, resting energy expenditure (REE), acylated and total ghrelin, leptin, insulin and glucose, and hunger and satiety sensations were evaluated. Linear regression models with mixed effects (fixed and random effects) helped to assess the variables between the two groups and within the groups. Results: Body weight and BMI decreased in both the experimental and control groups (P<0.001). After the high-fiber diet, postprandial acylated ghrelin (P=0.04), glucose (P<0.001), insulin (P=0.04), and leptin (P=0.03) levels as well as the HOMA-IR index (P=0.01) decreased, whereas satiety improved (P=0.02). Obese women that followed the conventional diet had increased body fat percentage (P=0.04) and lower REE (P=0.02). The two diets did not differ in terms of hunger sensation. Conclusion: A short-term high-fiber diet improves satiety sensations and metabolic parameters while suppressing postprandial acylated ghrelin (60 minutes) and maintaining the resting energy expenditure. Background mechanisms patients restriction Objective shortterm short term highfiber high fiber calorierestricted calorie restricted appetiteregulating appetite regulating hormones obesity Methds study (BMI 3 kgm2 kgm kg m2 m kg/m2 2 5 1000 (100 kcal/day kcalday kcal day days n=15 n15 n 15 (n=15 n=15, , REE, (REE) evaluated fixed Results P<0.001. P0001 P P<0.001 . 0 001 (P<0.001) P=0.04, P004 P=0.04 04 P<0.001, P=0.03 P003 03 (P=0.03 HOMAIR HOMA IR P=0.01 P001 01 (P=0.01 P=0.02. P002 P=0.02 02 (P=0.02) (P=0.04 sensation Conclusion 60 (6 minutes kg/m 100 (10 n=1 n1 1 (n=1 (REE P000 P<0.00 00 (P<0.001 P00 P=0.0 (P=0.0 (P=0.02 6 ( 10 (1 n= (n= P<0.0 (P<0.00 P0 P=0. (P=0. (n P<0. (P<0.0 P=0 (P=0 P<0 (P<0. P= (P= P< (P<0 (P (P<

RESUMO Contexto: Vários mecanismos, incluindo a fome excessiva, são responsáveis pelas dificuldades dos pacientes em manter a perda de peso e mudanças na dieta após a restrição calórica. Objetivo: Avaliar o efeito da dieta de curta duração rica em fibras e com restrição calórica nos hormônios reguladores do apetite e nas sensações de fome e saciedade em mulheres com obesidade. Métodos: Em um estudo randomizado controlado, 30 mulheres com índice de massa corporal (IMC) superior a 30 kg/m2 e com idade entre 20 e 50 anos foram hospitalizadas seguindo dieta com restrição calórica (1000 kcal/dia) por 3 dias. O grupo experimental (n=15) recebeu dieta rica em fibras e o grupo controle (n=15), dieta convencional. Foram avaliados peso corporal, IMC, gasto energético de repouso (GER), grelina acilada e total, leptina, insulina e glicose e sensações de fome e saciedade. Modelos de regressão linear com efeitos mistos (efeitos fixos e aleatórios) ajudaram a avaliar as variáveis entre os dois grupos e dentro dos grupos. Resultados: O peso corporal e o IMC diminuíram tanto no grupo experimental quanto no controle (P<0,001). Após a dieta rica em fibras, os níveis de grelina acilada pós-prandial (P=0,04), glicose (P<0,001), insulina (P=0,04) e leptina (P=0,03), bem como o índice HOMA-IR (P=0,01) diminuiu, enquanto a saciedade melhorou (P=0,02). Mulheres obesas que seguiram a dieta convencional apresentaram aumento do percentual de gordura corporal (P=0,04) e menor GER (P=0,02). As duas dietas não diferiram em termos de sensação de fome. Conclusão: Uma dieta rica em fibras de curto prazo melhora as sensações de saciedade e os parâmetros metabólicos, suprimindo a grelina acilada pós-prandial (60 minutos) e mantendo o gasto energético de repouso. Contexto mecanismos excessiva Objetivo obesidade Métodos controlado (IMC kgm2 kgm kg m2 m kg/m 2 5 1000 (100 kcal/dia kcaldia kcal dia dias n=15 n15 n 15 (n=15 n=15, , GER, (GER) total aleatórios Resultados P<0,001. P0001 P P<0,001 . 0 001 (P<0,001) pósprandial pós prandial P=0,04, P004 P=0,04 04 P<0,001, (P=0,04 P=0,03, P003 P=0,03 03 (P=0,03) HOMAIR HOMA IR P=0,01 P001 01 (P=0,01 diminuiu P=0,02. P002 P=0,02 02 (P=0,02) Conclusão metabólicos 60 (6 minutos 100 (10 n=1 n1 1 (n=1 (GER P000 P<0,00 00 (P<0,001 P00 P=0,0 (P=0,0 (P=0,03 (P=0,02 6 ( 10 (1 n= (n= P<0,0 (P<0,00 P0 P=0, (P=0, (n P<0, (P<0,0 P=0 (P=0 P<0 (P<0, P= (P= P< (P<0 (P (P<

ABSTRACT Objective This study investigated the factors associated with satisfactory early postoperative wound conditions. Method A prospective study was conducted with patients (n=179) submitted to osteosynthesis in general, in a hospital orthopedics service. In the preoperative period, patients underwent laboratory exams and the surgical indications were based on the type of fracture and the patient’s clinical conditions. In the postoperative period, patients were evaluated based on the presence of complications and considering their surgical wounds. Chi-square, Fisher, Mann-Whitney, and Kruskal-Wallis tests were used in the analysis. To identify the factors associated with wound condition, univariate and multiple logistic regression analysis was used. Results In the univariate analysis, each transferring unit reduction increased the chance of satisfactory outcome by 1.1% (p=0.0306; OR= 0.989 (1.011); 95%CI= 0.978;0.999; 1.001;1.023). The presence of SAH increased 2.7 fold the chance of satisfactory outcome (p=0.0424; OR= 2,667; 95%CI= 1,034;6,877). Hip fracture increased 2.6 fold the chance of satisfactory outcome (p=0.0272; OR=2.593; IC95%=1.113; 6.039). And the absence of a compound fracture increased 5.5 fold the chance of satisfactory wound outcome (p=0.0004; OR=5,493; 95%CI=2,132;14,149). In the multiple analysis, patients with non compound fractures were 9.7 times more likely to experience a satisfactory outcome when compared to patients with compound fractures (p=0.0014; OR=9,687; 95%CI= 2,399; 39,125). Conclusion There was an inverse relationship between plasma proteins levels and satisfactory surgical wounds outcome. Only exposure remained associated with wound conditions. Level Of Evidence: II, Prospective Study. conditions n=179 n179 n 179 (n=179 general service period patient s Chisquare, Chisquare Chi square, square Chi-square Fisher MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney KruskalWallis Kruskal Wallis condition 11 1 1.1 p=0.0306 p00306 p 0 0306 (p=0.0306 OR 0989 989 0.98 1.011 1011 011 (1.011) 95CI CI 95 95%CI 0.9780.999 09780999 0.978 0.999 978 999 0.978;0.999 1.0011.023. 10011023 1.001 1.023 . 001 023 1.001;1.023) 27 2 7 2. p=0.0424 p00424 0424 (p=0.0424 2,667 2667 667 1,0346,877. 10346877 1,034 6,877 034 6 877 1,034;6,877) 26 p=0.0272 p00272 0272 (p=0.0272 OR=2.593 OR2593 593 IC95%=1.113 IC951113 IC IC95 113 6.039. 6039 6.039 039 6.039) 55 5 5. p=0.0004 p00004 0004 (p=0.0004 OR=5,493 OR5493 493 95%CI=2,13214,149. 95CI213214149 95%CI=2,132 14,149 132 14 149 95%CI=2,132;14,149) 97 9 9. p=0.0014 p00014 0014 (p=0.0014 OR=9,687 OR9687 687 2,399 2399 399 39,125. 39125 39,125 39 125 39,125) Evidence II Study n=17 n17 17 (n=17 1. p=0.030 p0030 030 (p=0.030 098 98 0.9 1.01 101 01 (1.011 9780 0.9780.99 0978099 0978 0.97 0999 0.99 99 0.978;0.99 0011 1.0011.023 1001102 1001 1.00 1023 1.02 00 02 1.001;1.023 p=0.042 p0042 042 (p=0.042 2,66 266 66 0346 1,0346,877 1034687 1034 1,03 6877 6,87 03 87 1,034;6,877 p=0.027 p0027 027 (p=0.027 OR=2.59 OR259 59 IC95%=1.11 IC95111 IC9 603 6.03 p=0.000 p0000 000 (p=0.000 OR=5,49 OR549 49 13214 95%CI=2,13214,149 95CI21321414 95CI2132 95%CI=2,13 14149 14,14 13 95%CI=2,132;14,149 p=0.001 p0001 (p=0.001 OR=9,68 OR968 68 2,39 239 3912 39,12 3 12 n=1 n1 (n=1 p=0.03 p003 (p=0.03 09 0. 1.0 10 (1.01 0.9780.9 097809 097 099 0.978;0.9 1.0011.02 100110 100 102 1.001;1.02 p=0.04 p004 04 (p=0.04 2,6 1,0346,87 103468 103 1,0 6,8 8 1,034;6,87 p=0.02 p002 (p=0.02 OR=2.5 OR25 IC95%=1.1 IC9511 60 6.0 p=0.00 p000 (p=0.00 OR=5,4 OR54 4 1321 95%CI=2,13214,14 95CI2132141 95CI213 95%CI=2,1 1414 14,1 95%CI=2,132;14,14 OR=9,6 OR96 2,3 23 391 39,1 n= (n= p=0.0 p00 (p=0.0 (1.0 0.9780. 09780 0.978;0. 1.0011.0 10011 1.001;1.0 2, 1,0346,8 10346 1, 6, 1,034;6,8 OR=2. OR2 IC95%=1. IC951 6. OR=5, OR5 95%CI=2,13214,1 95CI213214 95CI21 95%CI=2, 141 14, 95%CI=2,132;14,1 OR=9, OR9 39, (n p=0. p0 (p=0. (1. 0.9780 0.978;0 1.0011. 1.001;1. 1,0346, 1,034;6, OR=2 IC95%=1 OR=5 95%CI=2,13214, 95CI21321 95CI2 95%CI=2 95%CI=2,132;14, OR=9 p=0 (p=0 (1 0.978; 1.0011 1.001;1 1,0346 1,034;6 IC95%= 95%CI=2,13214 95%CI=2,132;14 p= (p= ( 1.001; 1,034; IC95% 95%CI=2,1321 95%CI=2,132;1 (p 95%CI=2,132;

RESUMO Objetivo Este estudo investigou os fatores associados à condição satisfatória de ferida pós-operatória precoce. Método Foi desenvolvido um estudo prospectivo com pacientes (n=179) submetidos a osteossínteses em geral, em um serviço de ortopedia hospitalar. No período pré-operatório os pacientes foram submetidos a exames laboratoriais e as indicações cirúrgicas foram baseadas no tipo de fratura e condições clínicas. No período pós-operatório, os pacientes foram avaliados conforme a presença de complicações e feridas operatórias. Foram utilizados na análise os testes Qui-quadrado, Fisher, Mann-Whitney, Kruskal-Wallis. Para identificar os fatores associados à condição da ferida, foi utilizada a análise de regressão logística univariada e múltipla. Resultados Na análise univariada, cada unidade a menos de transferrina, aumentou a chance de condição satisfatória em 1.1% (p= 0.0306; OR= 0.989 (1.011); IC95%= 0.978;0.999; 1.001;1.023). A presença de HAS aumentou a chance de condição satisfatória em 2.7 vezes (p=0.0424; OR= 2.667; IC95%= 1.034;6.877). Fratura de quadril aumentou a chance de condição satisfatória em 2.6 vezes (p=0.0272; OR=2.593; IC95%=1.113;6.039). E não apresentar fratura exposta, aumentou a chance de condição satisfatória da ferida em 5.5 vezes (p=0.0004; OR=5.493; IC95%=2.132;14.149). Na análise múltipla, fraturas sem exposição, apresentaram chance 9.7 vezes maior de apresentar condição satisfatória do que insatisfatória; quando comparadas às que apresentaram exposição (p=0.0014; OR=9.687; IC95%= 2,399; 39.125). Conclusão Houve uma relação inversa entre proteínas plasmáticas e presença de feridas operatórias satisfatórias. Apenas a exposição se manteve associada à condição da ferida. Nível de Evidência: II; Estudo Prospectivo. pósoperatória pós operatória precoce n=179 n179 n 179 (n=179 geral hospitalar préoperatório pré operatório clínicas pósoperatório, pósoperatório operatório, pós-operatório Quiquadrado, Quiquadrado Qui quadrado, quadrado Qui-quadrado Fisher MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney KruskalWallis. KruskalWallis Kruskal Wallis. Wallis Kruskal-Wallis múltipla transferrina 11 1 1.1 p= p (p 0.0306 00306 0 0306 OR 0989 989 0.98 1.011 1011 011 (1.011) IC95 IC IC95% 0.9780.999 09780999 0.978 0.999 978 999 0.978;0.999 1.0011.023. 10011023 1.001 1.023 . 001 023 1.001;1.023) 27 2 7 2. p=0.0424 p00424 0424 (p=0.0424 2.667 2667 667 1.0346.877. 10346877 1.034 6.877 034 6 877 1.034;6.877) 26 p=0.0272 p00272 0272 (p=0.0272 OR=2.593 OR2593 593 IC95%=1.1136.039. IC9511136039 IC95%=1.113 6.039 113 039 IC95%=1.113;6.039) exposta 55 5 5. p=0.0004 p00004 0004 (p=0.0004 OR=5.493 OR5493 493 IC95%=2.13214.149. IC95213214149 IC95%=2.132 14.149 132 14 149 IC95%=2.132;14.149) 97 9 9. insatisfatória p=0.0014 p00014 0014 (p=0.0014 OR=9.687 OR9687 687 2,399 2399 399 39.125. 39125 39.125 39 125 39.125) satisfatórias Evidência II Prospectivo n=17 n17 17 (n=17 1. 0.030 0030 030 098 98 0.9 1.01 101 01 (1.011 IC9 9780 0.9780.99 0978099 0978 0.97 0999 0.99 99 0.978;0.99 0011 1.0011.023 1001102 1001 1.00 1023 1.02 00 02 1.001;1.023 p=0.042 p0042 042 (p=0.042 2.66 266 66 0346 1.0346.877 1034687 1034 1.03 6877 6.87 03 87 1.034;6.877 p=0.027 p0027 027 (p=0.027 OR=2.59 OR259 59 1136 IC95%=1.1136.039 IC951113603 IC951113 IC95%=1.11 6039 6.03 IC95%=1.113;6.039 p=0.000 p0000 000 (p=0.000 OR=5.49 OR549 49 13214 IC95%=2.13214.149 IC9521321414 IC952132 IC95%=2.13 14149 14.14 13 IC95%=2.132;14.149 p=0.001 p0001 (p=0.001 OR=9.68 OR968 68 2,39 239 3912 39.12 3 12 n=1 n1 (n=1 0.03 003 09 0. 1.0 10 (1.01 0.9780.9 097809 097 099 0.978;0.9 1.0011.02 100110 100 102 1.001;1.02 p=0.04 p004 04 (p=0.04 1.0346.87 103468 103 6.8 8 1.034;6.87 p=0.02 p002 (p=0.02 OR=2.5 OR25 IC95%=1.1136.03 IC95111360 IC95111 IC95%=1.1 603 6.0 IC95%=1.113;6.03 p=0.00 p000 (p=0.00 OR=5.4 OR54 4 1321 IC95%=2.13214.14 IC952132141 IC95213 IC95%=2.1 1414 14.1 IC95%=2.132;14.14 OR=9.6 OR96 2,3 23 391 39.1 n= (n= 0.0 (1.0 0.9780. 09780 0.978;0. 1.0011.0 10011 1.001;1.0 p=0.0 p00 (p=0.0 1.0346.8 10346 6. 1.034;6.8 OR=2. OR2 IC95%=1.1136.0 IC9511136 IC9511 IC95%=1. 60 IC95%=1.113;6.0 OR=5. OR5 IC95%=2.13214.1 IC95213214 IC9521 IC95%=2. 141 14. IC95%=2.132;14.1 OR=9. OR9 2, 39. (n (1. 0.9780 0.978;0 1.0011. 1.001;1. p=0. p0 (p=0. 1.0346. 1.034;6. OR=2 IC95%=1.1136. IC951 IC95%=1 IC95%=1.113;6. OR=5 IC95%=2.13214. IC9521321 IC952 IC95%=2 IC95%=2.132;14. OR=9 (1 0.978; 1.0011 1.001;1 p=0 (p=0 1.0346 1.034;6 IC95%=1.1136 IC95%=1.113;6 IC95%=2.13214 IC95%=2.132;14 ( 1.001; 1.034; IC95%=1.113; IC95%=2.1321 IC95%=2.132;1 IC95%=2.132;

ABSTRACT There are several factors associated with lower participation in regular physical activity (PA) in adult patients with epilepsy (PWEs). Objective: To assess the relationship between the regular practice of PA with clinical and cognitive variables and quality of life (QoL) in PWEs. Methods: Habitual Physical Activity Questionnaire (HPAQ) was related to clinical variables, scores on the Mini-Mental State Examination (MMSE), on the Brief Cognitive Battery-Edu (BCB-Edu), on the Satisfaction Scale for Physical Activity (SSPA), and on the Quality of Life in Epilepsy Inventory (QOLIE)-31 in 60 PWEs, with a significance level of p<0.05. Results: The PWEs had a mean age of 42.4±13.6 years, 50% of whom were female. Longer length of epilepsy correlated with lower PA in leisure time (Pearson correlation [r]= -0.276; p-value [p]=0.036). The occupational physical activity scores of the HPAQ correlated positively with perception (r=0.300; p=0.021), memory (r=0.381; p=0.003), semantic verbal fluency test (SVF) (r=0.427; p=0.001), and with the total score in the MMSE (r=0.327; p=0.012). The total HPAQ score correlated with the SVF (r=0.336; p=0.009) and with the MMSE (r=0.254; p=0.049). There was no correlation among the QOLIE–31, the HPAQ, and the SSPA. Conclusions: Longer duration of epilepsy was associated with the lower practice of PA. Physical activity was associated with better performance in aspects of cognition. There was no relationship between QoL and practice and satisfaction with PA, suggesting different psychosocial aspects involved. (PA . (PWEs) Objective (QoL Methods (HPAQ MiniMental Mini Mental MMSE, , (MMSE) BatteryEdu Battery Edu BCBEdu, BCBEdu BCB (BCB-Edu) SSPA, SSPA (SSPA) QOLIE31 QOLIE 31 (QOLIE)-3 6 p005 p 0 05 p<0.05 Results 424136 42 4 13 42.4±13. years 50 female Pearson r= r = [r] 0.276 0276 276 -0.276 pvalue value p=0.036. p0036 =0.036 036 [p]=0.036) r=0.300 r0300 300 (r=0.300 p=0.021, p0021 p=0.021 021 p=0.021) r=0.381 r0381 381 (r=0.381 p=0.003, p0003 p=0.003 003 p=0.003) (SVF r=0.427 r0427 427 (r=0.427 p=0.001, p0001 p=0.001 001 p=0.001) r=0.327 r0327 327 (r=0.327 p=0.012. p0012 p=0.012 012 p=0.012) r=0.336 r0336 336 (r=0.336 p=0.009 p0009 009 r=0.254 r0254 254 (r=0.254 p=0.049. p0049 p=0.049 049 p=0.049) QOLIE–31 Conclusions cognition involved (PWEs (MMSE (BCB-Edu (SSPA QOLIE3 3 (QOLIE)- p00 p<0.0 42413 1 42.4±13 5 [r 0.27 027 27 -0.27 p=0.036 p003 0036 =0.03 03 [p]=0.036 r=0.30 r030 30 (r=0.30 p002 p=0.02 02 r=0.38 r038 38 (r=0.38 p000 p=0.00 00 r=0.42 r042 (r=0.42 r=0.32 r032 32 (r=0.32 p001 p=0.01 01 r=0.33 r033 33 (r=0.33 r=0.25 r025 25 (r=0.25 p004 p=0.04 04 QOLIE–3 (QOLIE) p0 p<0. 4241 42.4±1 0.2 2 -0.2 p=0.03 =0.0 [p]=0.03 r=0.3 r03 (r=0.3 p=0.0 r=0.4 r04 (r=0.4 r=0.2 r02 (r=0.2 QOLIE– (QOLIE p<0 424 42.4± 0. -0. =0. [p]=0.0 r=0. r0 (r=0. p=0. p< 42.4 -0 =0 [p]=0. r=0 (r=0 p=0 42. - [p]=0 (r= p= [p]= (r [p] [p

RESUMO Existem vários fatores associados à menor participação em atividade física regular (AF) em pacientes adultos com epilepsia (PCE). Objetivo: Avaliar em PCEs a relação entre a prática regular de AF com as variáveis clínicas e cognitivas e com a qualidade de vida (QV). Métodos: Foi relacionado o Habitual Physical Activity Questionnaire (HPAQ) com as variáveis clínicas, escores no Mini-Mental State Examination (MMSE), no Brief Cognitive Battery-Edu (BCB-Edu), Satisfaction Scale for Physical Activity (SSPA) e no Quality of Life in Epilepsy Inventory (QOLIE–31) de 60 PCE, com nível de significância p<0,05. Resultados: Idade média 42,4±13,6 anos, 50% do sexo feminino. O maior tempo de epilepsia correlacionou-se com a menor prática de AF no lazer (Correlação de Person, r= -0,276; p=0,036). Escores da AF ocupacional do HPAQ correlacionaram-se positivamente com a percepção (r=0,300; p=0,021) e a memória (r=0,381; p=0,003) no teste de fluência verbal (SVF); (r=0,427; p=0,001) e com o escore total no MMSE (r=0,327; p=0,012). O escore total do HPAQ correlacionou-se com o SVF (r=0,336; p=0,009) e com o MMSE (r=0,254; p=0,049). Não houve correlação entre o QOLIE–31 com o HPAQ e a SSPA. Conclusão: A maior duração da epilepsia associou-se com a menor prática de AF. A AF associou-se com o melhor desempenho em aspectos da cognição. Não houve relação entre QV com a prática e a satisfação e a AF, sugerindo diferentes aspectos psicossociais envolvidos. (AF PCE. PCE . (PCE) Objetivo QV. (QV) Métodos (HPAQ MiniMental Mini Mental MMSE, , (MMSE) BatteryEdu Battery Edu BCBEdu, BCBEdu BCB (BCB-Edu) SSPA (SSPA QOLIE31 QOLIE 31 (QOLIE–31 6 p005 p 0 05 p<0,05 Resultados 424136 42 4 13 42,4±13, anos 50 feminino correlacionouse correlacionou se Correlação Person r 0,276 0276 276 -0,276 p=0,036. p0036 p=0,036 036 p=0,036) correlacionaramse correlacionaram r=0,300 r0300 300 (r=0,300 p=0,021 p0021 021 r=0,381 r0381 381 (r=0,381 p=0,003 p0003 003 (SVF) r=0,427 r0427 427 (r=0,427 p=0,001 p0001 001 r=0,327 r0327 327 (r=0,327 p=0,012. p0012 p=0,012 012 p=0,012) r=0,336 r0336 336 (r=0,336 p=0,009 p0009 009 r=0,254 r0254 254 (r=0,254 p=0,049. p0049 p=0,049 049 p=0,049) QOLIE–3 Conclusão associouse associou cognição envolvidos (PCE (QV (MMSE (BCB-Edu QOLIE3 3 (QOLIE–3 p00 p<0,0 42413 1 42,4±13 5 0,27 027 27 -0,27 p003 p=0,03 03 r=0,30 r030 30 (r=0,30 p=0,02 p002 02 r=0,38 r038 38 (r=0,38 p=0,00 p000 00 (SVF r=0,42 r042 (r=0,42 r=0,32 r032 32 (r=0,32 p001 p=0,01 01 r=0,33 r033 33 (r=0,33 r=0,25 r025 25 (r=0,25 p004 p=0,04 04 QOLIE– (QOLIE– p0 p<0, 4241 42,4±1 0,2 2 -0,2 p=0,0 r=0,3 r03 (r=0,3 r=0,4 r04 (r=0,4 r=0,2 r02 (r=0,2 (QOLIE p<0 424 42,4± 0, -0, p=0, r=0, r0 (r=0, p< 42,4 -0 p=0 r=0 (r=0 42, - p= (r= (r

ABSTRACT Objective: This study investigated the nutritional status, 25-hydroxyvitamin D (25OHD), albumin and risk factors associated with complications in patients with foot and ankle fragility fractures. Subjects and methods: Prospective study, developed with patients who suffered fractures due to fragility of the foot and ankle (n = 108); the type of fractured bone, fracture mechanisms and classification were studied and also pseudoarthrosis, treatment, surgical dehiscence, anthropometry, 25OHD and albumin. The Chi-square or Fisher's exact test, Mann-Whitney and Kruskal-Wallis tests were used in the statistical analysis and the multiple logistic regression analysis was used to identify the risk factors associated with complications. Results: The factors that, together, were associated with treatment complications were the level of 25OHD (p = 0.0055; OR = 0.868 [1,152]; 95% CI = 0.786; 0.959 [1.043;1.272]) and diabetes (p = 0.0034; OR = 30,181; 95% CI = 3.087; 295.036). The factors that, together, were associated with the presence of any complication, were age (p = 0.0139; OR = 1.058; 95% CI = 1.011; 1,106) and 25OHD level (p = 0.0198; OR = 0.917; 95% CI = 0.852; 0.986). There was a complication probability above 0.40 associated with lower 25OHD levels (values below 20 ng/mL) and older age (over 50 years). Conclusion: Lower or abnormal levels of 25OHD were associated with pseudoarthrosis, and age and 25OHD were both risk factors for treatment complications in patients with foot and ankle fractures. Objective status 25hydroxyvitamin hydroxyvitamin 25 25OHD, OHD , (25OHD) methods n 108 108) bone pseudoarthrosis dehiscence anthropometry Chisquare Chi square Fishers Fisher s test MannWhitney Mann Whitney KruskalWallis Kruskal Wallis Results that together p 0.0055 00055 0 0055 0868 868 0.86 1,152 1152 1 152 [1,152] 95 0.786 0786 786 0959 959 0.95 1.0431.272 10431272 1.043 1.272 043 272 [1.043;1.272] 0.0034 00034 0034 30,181 30181 30 181 3.087 3087 3 087 295.036. 295036 295.036 . 295 036 295.036) 0.0139 00139 0139 1.058 1058 058 1.011 1011 011 1,106 1106 106 0.0198 00198 0198 0.917 0917 917 0.852 0852 852 0.986. 0986 0.986 986 0.986) 040 40 0.4 values 2 ng/mL ngmL ng mL over 5 years. years years) Conclusion (25OHD 10 0.005 0005 005 086 86 0.8 1,15 115 15 [1,152 9 0.78 078 78 095 0.9 0431 1.0431.27 1043127 1043 1.04 1272 1.27 04 27 [1.043;1.272 0.003 0003 003 30,18 3018 18 3.08 308 08 29503 295.03 29 03 0.013 0013 013 1.05 105 05 1.01 101 01 1,10 110 0.019 0019 019 0.91 091 91 0.85 085 85 098 0.98 98 4 0. 0.00 000 00 8 1,1 11 [1,15 0.7 07 7 09 1.0431.2 104312 104 1.0 127 1.2 [1.043;1.27 30,1 301 3.0 2950 295.0 0.01 001 0.0 1, [1,1 1.0431. 10431 1. 12 [1.043;1.2 30, 3. 295. [1, 1.0431 [1.043;1. [1 [1.043;1 [ [1.043; [1.043 [1.04 [1.0 [1.

ABSTRACT BACKGROUND: Previous studies have shown a relationship between calf circumference (CC) and outcomes in hospitalized patients. AIMS: To investigate the relationship between CC and clinical and nutritional outcomes in older in-patients (OiP) in a surgery ward. METHODS: This was a cross-sectional study with 417 OiP in a surgery ward. Clinical variables, anthropometry, and nutritional screening instruments such as subjective global assessment (SGA), mini nutritional assessment (MNA), and nutritional risk screening (NRS) were used in the investigation. The tests Pearson’s chi-square, Mann-Whitney, Kruskal-Wallis, and Spearman’s coefficient, and multiple linear regression analyses were used to review the factors associated with CC. RESULTS: Lower CC values were found in the age group 80 years and over (p<0.0001), presence of complications (p=0.0269), NRS (p<0.0001), SGA (p<0.0001), and MNA (p<0.0001). Gender (p=0.0011; partial R2=0.01151), age (p=0.0002; partial R2=0.06032), body mass index (p≤0.0001; partial R2=0.40820), and arm circumference (p≤0.0001; partial R2=0.11890) are variables that together were associated with CC. There was also a relationship between SGA (p=0.0166; partial R2=0.00605) and absence of complications during hospitalization (p=0.0047; R2=0.01154) with CC. CONCLUSIONS: Gender, age, body mass index, and arm circumference were jointly associated with CC, in addition to SGA and absence of complications. The CC is a relevant indicator for OiP in the clinical practice. BACKGROUND (CC patients AIMS inpatients (OiP ward METHODS crosssectional cross sectional 41 anthropometry SGA, , (SGA) MNA, (MNA) (NRS investigation Pearsons Pearson s chisquare, chisquare chi square, square chi-square MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney KruskalWallis, KruskalWallis Kruskal Wallis, Wallis Kruskal-Wallis Spearmans Spearman coefficient RESULTS 8 p<0.0001, p00001 p p<0.0001 0 0001 (p<0.0001) p=0.0269, p00269 p=0.0269 0269 (p=0.0269) p<0.0001. . p=0.0011 p00011 0011 (p=0.0011 R2=0.01151, R2001151 R R2=0.01151 R2 01151 R2=0.01151) p=0.0002 p00002 0002 (p=0.0002 R2=0.06032, R2006032 R2=0.06032 06032 R2=0.06032) p≤0.0001 (p≤0.0001 R2=0.40820, R2040820 R2=0.40820 40820 R2=0.40820) R2=0.11890 R2011890 11890 p=0.0166 p00166 0166 (p=0.0166 R2=0.00605 R2000605 00605 p=0.0047 p00047 0047 (p=0.0047 R2=0.01154 R2001154 01154 CONCLUSIONS practice 4 (SGA (MNA p0000 p<0.000 000 (p<0.0001 p0026 p=0.026 026 (p=0.0269 p=0.001 p0001 001 (p=0.001 R200115 R2=0.0115 0115 p=0.000 (p=0.000 R200603 R2=0.0603 0603 p≤0.000 (p≤0.000 R204082 R2=0.4082 4082 R2=0.1189 R201189 1189 p=0.016 p0016 016 (p=0.016 R2=0.0060 R200060 0060 p=0.004 p0004 004 (p=0.004 p000 p<0.00 00 (p<0.000 p002 p=0.02 02 (p=0.026 p=0.00 (p=0.00 R20011 R2=0.011 011 R20060 R2=0.060 060 p≤0.00 (p≤0.00 R20408 R2=0.408 408 R2=0.118 R20118 118 p=0.01 p001 01 (p=0.01 R2=0.006 R20006 006 p00 p<0.0 (p<0.00 p=0.0 (p=0.02 (p=0.0 R2001 R2=0.01 R2006 R2=0.06 06 p≤0.0 (p≤0.0 R2040 R2=0.40 40 R2=0.11 R2011 11 R2=0.00 R2000 p0 p<0. (p<0.0 p=0. (p=0. R200 R2=0.0 p≤0. (p≤0. R204 R2=0.4 R2=0.1 R201 1 p<0 (p<0. p=0 (p=0 R20 R2=0. p≤0 (p≤0 p< (p<0 p= (p= R2=0 p≤ (p≤ (p< (p R2=

RESUMO RACIONAL: Estudos anteriores mostraram uma relação entre a circunferência da panturrilha (CP) e desfechos em pacientes hospitalizados. OBJETIVOS: Investigar a relação entre CP e desfecho clínico e nutricional em pacientes idosos hospitalizados (PIH) em uma enfermaria cirúrgica. MÉTODOS: Este foi um estudo transversal com 417 PIH em uma enfermaria de cirurgia. Variáveis clínicas, antropometria e instrumentos de triagem nutricional como avaliação subjetiva global (ASG), mini avaliação nutricional (MAN) e triagem de risco nutricional (NRS) foram utilizados na investigação. Qui-quadrado, Mann-Whitney, Kruskal-Wallis, coeficiente de Spearman e análise de regressão linear múltipla foram usados para analisar os fatores associados a CP. RESULTADOS: Menores valores de CP foram encontrados na faixa etária de 80 anos (p<0,0001), complicações (p=0,0269), risco nutricional pelo NRS (p<0,0001), ASG (p<0,0001) e MAN (p<0,0001). Sexo (p=0,0011; R2 parcial=0,01151), idade (p=0,0002; R2 parcial=0,06032), IMC (p≤0,0001; R2 parcial=0,40820) e circunferência do braço (CB) (p≤0,0001; R2 parcial=0,11890) foram variáveis que juntas estiveram associadas com a CP. Também houve relação entre ASG (p=0,0166; R2 parcial=0,00605) e ausência de complicações durante a internação (p=0,0047; R2= 0,01154) com a CP. CONCLUSÕES: Sexo, idade, IMC e CB associaram-se conjuntamente com CP, ASG e ausência de complicações. CP é um indicador relevante em PIH na prática clínica. RACIONAL (CP OBJETIVOS (PIH cirúrgica MÉTODOS 41 cirurgia clínicas ASG, , (ASG) (MAN (NRS investigação Quiquadrado, Quiquadrado Qui quadrado, quadrado Qui-quadrado MannWhitney, MannWhitney Mann Whitney, Whitney Mann-Whitney KruskalWallis, KruskalWallis Kruskal Wallis, Wallis Kruskal-Wallis RESULTADOS 8 p<0,0001, p00001 p p<0,0001 0 0001 p=0,0269, p00269 p=0,0269 0269 (p=0,0269) (p<0,0001 p<0,0001. . p=0,0011 p00011 0011 (p=0,0011 R parcial=0,01151, parcial001151 parcial parcial=0,01151 01151 parcial=0,01151) p=0,0002 p00002 0002 (p=0,0002 parcial=0,06032, parcial006032 parcial=0,06032 06032 parcial=0,06032) p≤0,0001 (p≤0,0001 parcial=0,40820 parcial040820 40820 (CB parcial=0,11890 parcial011890 11890 p=0,0166 p00166 0166 (p=0,0166 parcial=0,00605 parcial000605 00605 p=0,0047 p00047 0047 (p=0,0047 0,01154 001154 01154 CONCLUSÕES associaramse associaram se clínica 4 (ASG p0000 p<0,000 000 p0026 p=0,026 026 (p=0,0269 (p<0,000 p=0,001 p0001 001 (p=0,001 parcial00115 parcial=0,0115 0115 p=0,000 (p=0,000 parcial00603 parcial=0,0603 0603 p≤0,000 (p≤0,000 parcial=0,4082 parcial04082 4082 parcial=0,1189 parcial01189 1189 p=0,016 p0016 016 (p=0,016 parcial=0,0060 parcial00060 0060 p=0,004 p0004 004 (p=0,004 0,0115 00115 p000 p<0,00 00 p002 p=0,02 02 (p=0,026 (p<0,00 p=0,00 (p=0,00 parcial0011 parcial=0,011 011 parcial0060 parcial=0,060 060 p≤0,00 (p≤0,00 parcial=0,408 parcial0408 408 parcial=0,118 parcial0118 118 p=0,01 p001 01 (p=0,01 parcial=0,006 parcial0006 006 0,011 p00 p<0,0 p=0,0 (p=0,02 (p<0,0 (p=0,0 parcial001 parcial=0,01 parcial006 parcial=0,06 06 p≤0,0 (p≤0,0 parcial=0,40 parcial040 40 parcial=0,11 parcial011 11 parcial=0,00 parcial000 0,01 p0 p<0, p=0, (p<0, (p=0, parcial00 parcial=0,0 p≤0, (p≤0, parcial=0,4 parcial04 parcial=0,1 parcial01 1 0,0 p<0 p=0 (p<0 (p=0 parcial0 parcial=0, p≤0 (p≤0 0, p< p= (p< (p= parcial=0 p≤ (p≤ (p parcial=

RESUMO Contexto A prevalência de pacientes idosos hospitalizados tem crescido substancialmente e impactado os serviços de saúde hospitalar. Desta forma, acredita-se que uma investigação do estado nutricional, associado a situações clínicas variadas em pacientes idosos, poderia contribuir para ações de intervenção hospitalar multidisciplinares e de cuidado nutricional adequadas para esta população. Objetivo Investigar a relação entre dois instrumentos de triagem nutricional em pacientes idosos hospitalizados e comparar variáveis clínicas entre estes dois instrumentos. Métodos Estudo retrospectivo com pacientes idosos hospitalizados (n=277), sendo investigado a concordância entre dois instrumentos de triagem nutricional. Os dados foram analisados pelos testes McNemar, qui-quadrado, Fisher, Mann-Whitney e o coeficiente kappa para a avaliação de concordância. Resultados Houve diferença significativa (P=0,0002) entre as classificações de risco nutricional pelos dois instrumentos de triagem nutricional e concordância moderada (k=0,5430) entre eles. Verificou-se associação entre triagem de risco nutricional e idade (P=0,0255), tempo de internação (P<,0001), sexo (P=0,0365) e doenças (P=0,0001). Houve associação entre a Mini Avaliação Nutricional e tempo de internação (P<0,0001), doenças (P=0,0001) e evolução do peso corporal (P=0,0479). Conclusão Triagem de risco nutricional e a Mini Avaliação Nutricional apresentam concordância moderada para a avaliação de pacientes idosos.

ABSTRACT Background The prevalence of hospitalized elderly patients has grown substantially and has impacted the hospital health services. Thus, it is believed that an investigation of the nutritional status associated with different clinical situations in elderly patients could contribute to multidisciplinary hospital intervention and nutritional care actions suitable for this population. Objective To investigate the relationship between two nutritional screening instruments in hospitalized older patients and to compare clinical variables between these two instruments. Methods Retrospective study with hospitalized older patients (n=277), investigating the agreement between two nutritional screening instruments. The data were analyzed using the McNemar, chi-square, Fisher, Mann-Whitney tests and the kappa coefficient for the agreement assessment. Results There was a significant difference (P=0.0002) between the nutritional risk classifications of the two nutritional screening instruments and moderate agreement (k=0.5430) between them. The association between nutritional risk screening and age (P=0.0255), length of hospital stay (P<0.0001), gender (P=0.0365) and illness (P=0.0001) were assessed. There was an association between Mini Nutritional Assessment and length of stay (P<0.0001), illness (P=0.0001) and body weight evolution (P=0.0479). Conclusion The nutritional risk screening and Mini Nutritional Assessment showed moderate agreement in the assessment of elderly patients.

RESUMO Introdução: recentemente tem-se estudado a variável densidade linfonodal como possível influenciador na sobrevida de pacientes com diagnóstico de câncer de cabeça e pescoço. Objetivo: analisar a relação entre a densidade linfonodal e a sobrevida de pacientes recidivados previamente submetidos a cirurgia de esvaziamento cervical por carcinoma espinocelular de cabeça e pescoço. Método: foram analisados retrospectivamente 71 prontuários pacientes atendidos no Serviço de Cirurgia de Cabeça e Pescoço da Pontifícia Universidade Católica de Campinas que tinham sido submetidos a cirurgia de esvaziamento cervical e apresentaram recidiva tumoral entre os anos de 2006 e 2019. Dados relativos ao paciente e ao tumor tais como: idade, sexo, cor da pele, tabagismo, etilismo, localização do tumor primário, características anatomopatológicas e status linfonodal foram correlacionados ao tempo de sobrevida dos indivíduos. Resultados: encontramos predominância do sexo masculino e a média de idade foi de 59,5 anos. O sítio primário mais frequente foi a cavidade oral seguido da laringe e orofaringe. A taxa de mortalidade foi de 53,52% e a densidade linfonodal média 0,28. Encontramos influência na sobrevida com significância estatística para os parâmetros: densidade linfonodal, número de linfonodos dissecados e acometidos, estadiamento T e N, tipo de tratamento proposto (paliativo ou cirúrgico), presença de margens comprometidas no tumor primário e extravasamento linfonodal. Conclusão: o cálculo da densidade linfonodal em pacientes recidivados após cirurgia de esvaziamento cervical por carcinoma espinocelular de cabeça e pescoço deve ser levado em consideração durante o planejamento terapêutico e na avaliação prognóstica devido à sua direta influencia na sobrevida dos indivíduos.

ABSTRACT Introduction: the variable lymph node ratio has recently been studied as a possible influencer in the survival of patients diagnosed with head and neck cancer. Objective: to analyze the correlation between lymph node density and survival of recurred disease patients previously submitted to cervical dissection surgery due to head and neck squamous cell carcinoma. Method: we retrospectively analyzed 71 medical records of patients treated at the Head and Neck Surgery Service of the Pontifícia Universidade Católica de Campinas who had undergone cervical dissection surgery and presented tumor recurrence between 2006 and 2019. Patient and tumor data such as age, gender, skin color, smoking, alcohol consumption, location of the primary tumor, anatomopathological characteristics and lymph node status were correlated with the survival time. Results: we found a predominance of males and the mean age was 59.5 years. The most frequent primary site was the oral cavity followed by the larynx and oropharynx. The mortality rate was 53.52% and the mean lymph node ratio 0.28. We found influence on survival with statistical significance for the parameters: lymph node ratio, number of dissected and affected lymph nodes, T and N staging, type of treatment proposed (palliative or surgical), presence of compromited margins in the primary tumor and lymph node extravasation. Conclusion: the calculation of lymph node density in patients with recurred disease after cervical dissection surgery by head and neck squamous cell carcinoma should be taken into account during therapeutic planning and prognostic evaluation due to its direct influence on the survival.

Abstract Objective: the aim of this study was to assess weight loss, diet prescribed, and nutritional status in hospitalized patients, as well as their associated factors. Methods: weight loss during hospitalization, nutritional status, disease type, and prescribed diet were investigated in a retrospective study in 621 hospitalized patients. The chi-squared, Fisher's, Mann-Whitney, and Kruskal-Wallis tests were used for statistical analysis. To identify factors associated with weight loss a logistic regression analysis was performed. The significance level adopted for statistical tests was 5 %. Results: patients who experienced weight loss during hospitalization were associated with longer hospital stays (p < 0.0001; OR = 1.052; 95 % CI = 1.030 to 1.073), malnourishment according to the subjective global assessment (p = 0.0358; OR = 1.520; 95 % CI = 1,028 to 2,248), digestive disorders (p = 0.0081; OR = 3.177; 95 % CI = 1.351 to 7.469), and digestive neoplasms (p = 0.0407; OR = 2.410; 95 % CI = 1.038 to 5.597). Conclusion: weight loss during hospitalization was associated with neoplasms, digestive diseases, malnutrition, and length of stay.

Resumen Objetivo: el objetivo de este estudio fue evaluar la pérdida de peso, la dieta prescrita y el estado nutricional de pacientes hospitalizados y sus factores asociados. Métodos: se investigó la pérdida de peso durante la hospitalización, el estado nutricional, el tipo de enfermedad y la dieta prescrita en un estudio retrospectivo de 621 pacientes hospitalizados. Las pruebas del chi cuadrado, Fisher, Mann-Whitney y Kruskal-Wallis se utilizaron para el análisis estadístico. Para identificar los factores asociados con la pérdida de peso se utilizó la regresión logística. El nivel de significación adoptado para las pruebas estadísticas fue del 5 %. Resultados: los casos de pérdida de peso durante la hospitalización se asociaron a las estancias hospitalarias más largas (p < 0,0001; OR = 1,052; IC 95 % = 1,030; 1,073), la desnutrición según la evaluación global subjetiva (p = 0,0358; OR = 1,520; IC 95 % = 1,028; 2,248) los trastornos digestivos (p = 0,0081; OR = 3,177; IC 95 % = 1,351; 7,469) y las neoplasias digestivas (p = 0,0407; OR = 2,410; IC 95 % = 1,038; 5,597). Conclusión: la pérdida de peso durante la hospitalización se asoció con las neoplasias y las enfermedades digestivas, la desnutrición y la duración de la estancia.

Resumo Objetivos: avaliar o impacto da codetecção de Influenza A (FluA) e Vírus Sincicial Respiratório (VSR) por meio de testes imunocromatográficos rápidos em tempo real, em pacientes menores de 2 anos em hospital público e universitário. Métodos: estudo de coorte retrospectivo foi conduzido para analisar os desfechos clínicos de crianças hospitalizadas com doença respiratória viral com resultados positivos do teste rápido imunocromatográfico para VSR e/ou FluA, de 2013 a 2018. Um modelo de regressão logística foi ajustado para analisar preditores de intubação orotraqueal durante a internação. Resultados: foram analisados 220 casos: RSV (192), FluA (9) eco-detecção (19). A letalidade foi de 1,8% (2 casos) e 88% (194) casos em menores de 1 ano. O tempo médio de internação foi maior nos pacientes com codetecção. As variáveis significativamente associadas à intubação orotraqueal foram: menor idade em meses, comorbidades, codetecção de VSR e Flu-A e pneumonia bacteriana durante a internação. Conclusões: codetecção VSR e FluA foi associada a prognósticos clínicos desfavoráveis. O teste rápido fornece informações importantes a beira-leito, pois os painéis moleculares não são amplamente acessíveis em hospitais públicos. O diagnóstico rápido permite a avaliação e tratamento oportunos.

Abstract Objectives: the aim of this study is to evaluate the impact of co-detection of Flu A and RSV using rapid immunochromatographic tests at the point of care, in pediatric patients under 2 years of age in a general hospital. Methods: a retrospective cohort study was conducted to analyze clinical outcomes in hospitalized infants with viral respiratory disease with positive results of rapid immunochromatographic test for RSV and/or Flu-A, from 2013 to 2018. A logistic regression model was adjusted to analyze predictors of orotracheal intubation during hospitalization. Results: we analyzed 220 cases: RSV (192), Flu-A (9), co-detection (19). Lethality rate was 1.8% (2 cases), and 88% (194) were under 1 year of age. Mean time of hospitalizations was higher in patients with co-detection. Variables significantly associated with orotracheal intubation were: younger age in months, comorbidities, RSV and Flu-A co-detection, and bacterial pneumonia during hospitalization. Conclusions: RSV and Flu-Aco-detection was associated with the least favorable clinical prognoses in this study. Rapid test diagnosis may provide important information at the point of care, because molecular panels are not widely accessible in general hospitals. Rapid diagnosis allows timely evaluation and treatment.

ABSTRACT Objective: To assess whether there are differences between oral problems and food, energy, and nutrient intake and anthropometric indicators of institutionalized older adults. Methods: A total of 150 older people participated in the study. Their nutritional status was determined by anthropometric indicators and food intake. Oral problems were examined by a trained dentist who checked for caries, periodontitis, dry mouth, edentulism, and poorly-fitting partial or complete dentures. The categorical variables were analyzed by the Fisher's Exact Test and the continuous variables were analyzed by the Student's t-test for parametric data and the Mann–Whitney test for nonparametric data (p≤0.05). Results: Older people with oral problems presented lower anthropometric measurements and indices except for biceps skinfold thickness and consumed less energy (p= 0.027), protein (p= 0.012), lipids (0.012), and pan-fried meats (p= 0.001). Conclusion: Anthropometric indicators and the energy, protein and lipid intake were lower in elderly people with oral problems. This work warns about the importance of oral health for the good nutrition of older people and the need to establish strategies to adapt the diet of this population.

RESUMEN Objetivo: Evaluar si existe una diferencia entre los problemas orales y la ingesta de alimentos, energía y nutrientes e indicadores antropométricos de adultos mayores institucionalizados. Métodos: Un total de 150 personas mayores participaron en el estudio. Su estado nutricional se determinó mediante indicadores antropométricos y la ingesta de alimentos. Los problemas orales fueron examinados por un dentista capacitado que verificó la presencia de caries, periodontitis, boca seca, edentulismo y dentaduras postizas parciales o completas mal ajustadas. Las variables categóricas se evaluaron mediante la Prueba Exacta de Fisher y las variables continuas se evaluaron mediante la prueba t de Student para datos paramétricos y la prueba de Mann-Whitney para datos no paramétricos (p≤0.05). Resultados: Las personas mayores con problemas orales presentaron mediciones e índices antropométricos más bajos, excepto el grosor del pliegue cutáneo del bíceps y consumieron menos energía (p= 0.027), proteínas (p= 0.012), lípidos (0.012) y carnes fritas (p= 0.001). Conclusión: Los indicadores antropométricos y el consumo de energía, proteínas y lípidos fueron menores en personas mayores con problemas bucales. Este trabajo advierte sobre la importancia de la salud oral para la buena nutrición de las personas mayores y la necesidad de establecer estrategias para adaptar la dieta de esta población.

RESUMO CONTEXTO: Pacientes oncológicos podem apresentar alterações gastrointestinais que influenciam o estado nutricional. OBJETIVO: Investigar a ocorrência de alterações gastrointestinais decorrentes do tratamento ambulatorial de quimioterapia, em pacientes oncológicos. MÉTODOS: Num estudo longitudinal retrospectivo, investigou-se o estado nutricional e as alterações gastrointestinais (náuseas, vômito, diarreia, constipação, mucosite, disfagia, xerostomia, inapetência, disgeusia e pirose) de pacientes oncológicos (n=187), em acompanhamento ambulatorial de quimioterapia. Para o estudo dos parâmetros ao longo do tempo, utilizou-se o método das equações de estimação generalizadas (EEG). Também foram utilizados os testes de Kruskal-Wallis, Mann-Whitney e o coeficiente de Spearman, com nível de significância de 5%. RESULTADOS: A maioria dos pacientes era do sexo feminino (63,64%) e a média de idade foi 57,5±12,1 anos. Os sintomas mais frequentes foram náuseas (18,54%); inapetência (18,31%); constipação intestinal (11,58%); diarreia (7,98%); xerostomia (7,59%) e vômito (7,43%). O estado nutricional não apresentou alterações relevantes (P=0,7594). No entanto, observou-se maior prevalência de eutrofia, seguido do sobrepeso e o vômito apresentou diferença significativa (P=0,0211). O sintoma de náusea apresentou diferença significativa com maior prevalência na neoplasia colorretal, quando comparado à neoplasia de mama (P=0,0062); assim como o vômito nas neoplasias de pulmão e colorretal (P=0,0022). E a disfagia, na neoplasia de cabeça e pescoço, quando comparada às demais neoplasias (P<0,001). Houve diferença estatisticamente significante entre o número de consultas médicas e sexo (P=0,0102) e entre disfagia e sexo (P<0,0001). CONCLUSÃO: Os achados encontrados no estudo permitem reforçar a necessidade do acompanhamento de sinais e sintomas, bem como do estado nutricional, de pacientes em acompanhamento ambulatorial de quimioterapia.

ABSTRACT BACKGROUND: Cancer patients may have gastrointestinal changes that influence nutritional status. OBJECTIVE: To investigate the occurrence of gastrointestinal changes resulting from outpatient chemotherapy treatment in cancer patients. METHODS: In a retrospective longitudinal study, the nutritional status and chemotherapy gastrointestinal changes (nausea, vomit, diarrhea, constipation, mucositis, dysphagia, xerostomia, inappetence, dysgeusia and heartburn) in cancer patients (n=187) were investigated in an outpatient follow-up. For the study of the parameters over time, the generalized estimating equation (GEE) method was used. Kruskal-Wallis, Mann-Whitney tests and Spearman coefficient, at a significance level of 5% were also used. RESULTS: The majority of the patients were female (63.64%) and the mean age was 57.5±12.1 years. The most frequent symptoms were nausea (18.54%); inappetence (18.31%); intestinal constipation (11.58%); diarrhea (7.98%); xerostomia (7.59%) and vomiting (7.43%). The nutritional status did not exhibit any relevant changes (P=0.7594). However, a higher prevalence of eutrophy was observed, followed by overweight; vomiting exhibited a significant difference (P=0.0211). The nausea symptom exhibited a significant difference with a higher prevalence of colorectal neoplasia when compared to breast neoplasia (P=0.0062); as well as vomiting in lung and colorectal neoplasias (P=0.0022), and dysphagia, in head and neck neoplasia, when compared to other neoplasms (P<0.001). There was a statistically significant difference between the number of medical appointments and gender (P=0.0102) and between dysphagia and gender (P<0.0001). CONCLUSION: The study findings enhance the need for signs and symptoms follow up, as well as nutritional status follow up of patients undergoing outpatient chemotherapy.

RESUMO Objetivo O objetivo deste trabalho foi revisar as publicações que trataram da terapia nutricional do paciente hospitalizado com Covid-19 desde o início da pandemia até o mês de setembro de 2020. Métodos Trata-se de uma revisão dos trabalhos indexados nas bases de dados Scopus, Pubmed e Lilacs, incluindo consensos da área. Resultados A revisão mostrou que as recomendações iniciais pautaram-se em pressupostos genéricos e, conforme o conhecimento específico foi sendo produzido, as recomendações passaram a ser mais direcionadas. Conclusão Na crise sanitária gerada pela Covid-19, no contexto de incertezas relacionadas aos procedimentos de atenção nutricional, foram gerados conhecimentos e estratégias de ação, coordenados por pesquisadores e profissionais de saúde.

ABSTRACT Objective The objective of this work was to review papers that deal with nutritional therapy of inpatients with Covid-19 from the beginning of the pandemic. The survey covered the period until the month of September 2020. Methods This is a review of the indexed literature (Scopus, Pubmed and Lilacs), including area consensus. Results The review showed that the initial recommendations were based on generic assumptions and, as specific knowledge was being produced, the recommendations became more targeted. Conclusion In the health crisis generated by Covid-19, in the context of uncertainties related to nutritional care procedures, knowledge and action strategies were generated, coordinated by researchers and health professionals.