ABSTRACT Objective: To investigate exclusive breastfeeding (EBF) intention and associated variables among women in the third trimester of pregnancy. Methods: The data were collected with a questionnaire for the pregnant women (n=653), from December/2018 to November/2019. They answered the Infant Feeding Intentions (IFI) scale, translated and adapted to Brazilian Portuguese, and a questionnaire on sociodemographic, biological, family, pregnancy, breastfeeding, health care, and habits variables. Descriptive statistics and multiple logistic regression analyses were performed with a 5% significance level, following a multilevel hierarchical model that estimated the association between the dependent and independent variables. The outcome EBF intention measured by the IFI score was dichotomized by the median (<16 or =16). Results: Mean±standard deviation score for the IFI scale was 14.4±2.6 (score 0: very strong intention to not breastfeed at all; score 16: very strong EBF intention up to six months). The results from the regression analysis showed that pregnant women who had no intention to bottle feed (OR=4.33; 95%CI 2.79-6.72) or did not know (OR=1.85; 95%CI 1.21–2.82), those who planned the pregnancy (OR=1.52; 95%CI 1.09–2.12), those who believed they would have help to care for the baby (OR=3.60; 95%CI 1.51–8.56) or did not know (OR=3.97; 95%CI 1.26–12.51), and those who reported knowing the World Health Organization recommendations on breastfeeding (OR=1.73; 95%CI 1.13–2.64) were more likely to show a very strong EBF intention. Conclusions: Pregnant women in the third trimester of pregnancy presented a strong EBF intention. The higher EBF intention score was significantly associated with the structural, setting, and individual determinants. Objective (EBF Methods n=653, n653 n n=653 , 653 (n=653) December2018 December 2018 December/201 November2019 November 2019 November/2019 (IFI Portuguese sociodemographic biological family 5 level <16 16 (<1 =16. =16 . =16) Results Meanstandard Mean standard 14426 14 4 2 6 14.4±2. 0 all months. months months) OR=4.33 OR433 OR 33 (OR=4.33 95CI CI 95 2.796.72 279672 2.79 6.72 79 72 2.79-6.72 OR=1.85 OR185 1 85 (OR=1.85 1.21–2.82, 121282 1.21–2.82 21 82 1.21–2.82) OR=1.52 OR152 52 (OR=1.52 1.09–2.12, 109212 1.09–2.12 09 12 1.09–2.12) OR=3.60 OR360 3 60 (OR=3.60 1.51–8.56 151856 51 8 56 OR=3.97 OR397 97 (OR=3.97 1.26–12.51, 1261251 1.26–12.51 26 1.26–12.51) OR=1.73 OR173 73 (OR=1.73 1.13–2.64 113264 13 64 Conclusions structural setting determinants n65 n=65 65 (n=653 December201 201 December/20 November201 November/201 <1 (< =1 1442 14.4±2 OR=4.3 OR43 (OR=4.3 9 796 2.796.7 27967 279 2.7 672 6.7 7 2.79-6.7 OR=1.8 OR18 (OR=1.8 12128 1.21–2.8 OR=1.5 OR15 (OR=1.5 10921 1.09–2.1 OR=3.6 OR36 (OR=3.6 1.51–8.5 15185 OR=3.9 OR39 (OR=3.9 126125 1.26–12.5 OR=1.7 OR17 (OR=1.7 1.13–2.6 11326 n6 n=6 (n=65 December20 20 December/2 November20 November/20 < ( = 144 14.4± OR=4. OR4 (OR=4. 2.796. 2796 27 2. 67 6. 2.79-6. OR=1. OR1 (OR=1. 1212 1.21–2. 1092 1.09–2. OR=3. OR3 (OR=3. 1.51–8. 1518 12612 1.26–12. 1.13–2. 1132 n= (n=6 December2 December/ November2 November/2 14.4 OR=4 (OR=4 2.796 2.79-6 OR=1 (OR=1 121 1.21–2 109 1.09–2 OR=3 (OR=3 1.51–8 151 1261 1.26–12 1.13–2 113 (n= November/ 14. OR= (OR= 2.79- 1.21– 10 1.09– 1.51– 15 126 1.26–1 1.13– 11 (n (OR 1.21 1.09 1.51 1.26– 1.13 1.2 1.0 1.5 1.26 1.1 1.

RESUMO Objetivo: Investigar a intenção materna de amamentar exclusivamente (IMA) e variáveis associadas entre as mulheres no terceiro trimestre de gravidez. Métodos: A coleta de dados foi realizada por meio de entrevista e questionário semiestruturado e autoadministrado, entre dezembro/2018 e novembro/2019. As gestantes (n=653) responderam à escala Infant Feeding Intentions (IFI) testada, traduzida e adaptada para o português do Brasil e ao questionário contendo perguntas sobre variáveis sociodemográficas, biológicas e familiares, bem como relacionadas à gestação, ao aleitamento materno, à assistência à saúde e a hábitos. Foram realizadas análises estatísticas descritivas e de regressão logística múltipla hierarquizada, com nível de significância de 5%, para estimar a associação entre as variáveis independentes e o desfecho. A IMA, medida pela escala IFI, foi dicotomizada pela mediana (<16 ou =16). Resultados: A pontuação média±desvio padrão para a escala IFI foi de 14,4±2,6. Os resultados da análise de regressão mostraram que as gestantes que não tinham intenção de oferecer mamadeira (OR=4,33; IC95% 2,79-6,72) ou não sabiam (OR=1,85; IC95% 1,21–2,82), que planejaram a gestação (OR=1,52; IC95% 1,09–2,12), aquelas que acreditavam que teriam ajuda nos cuidados com o bebê (OR=3,60; IC95% 1,51–8,56) ou que não sabiam (OR=3,97; IC95% 1,26–12,51), bem como aquelas que relataram conhecer as recomendações da Organização Mundial de Saúde sobre amamentação (OR=1,73; IC95% 1.13–2.64) tinham mais chances de mostrar uma IMA muito forte. Conclusões: As gestantes no terceiro trimestre de gestação apresentaram forte IMA. A maior IMA esteve significativamente associada aos determinantes estruturais, contextuais e individuais. Objetivo (IMA gravidez Métodos autoadministrado dezembro2018 dezembro 2018 dezembro/201 novembro2019 novembro 2019 novembro/2019 n=653 n653 n 653 (n=653 (IFI testada sociodemográficas familiares materno hábitos hierarquizada 5 5% desfecho <16 16 (<1 =16. =16 . =16) Resultados médiadesvio média desvio 14426 14 4 2 6 14,4±2,6 OR=4,33 OR433 OR 33 (OR=4,33 IC95 IC 2,796,72 279672 2,79 6,72 79 72 2,79-6,72 OR=1,85 OR185 1 85 (OR=1,85 1,21–2,82, 121282 1,21–2,82 , 21 82 1,21–2,82) OR=1,52 OR152 52 (OR=1,52 1,09–2,12, 109212 1,09–2,12 09 12 1,09–2,12) OR=3,60 OR360 3 60 (OR=3,60 1,51–8,56 151856 51 8 56 OR=3,97 OR397 97 (OR=3,97 1,26–12,51, 1261251 1,26–12,51 26 1,26–12,51) OR=1,73 OR173 73 (OR=1,73 1.13–2.64 113264 13 64 Conclusões estruturais individuais dezembro201 201 dezembro/20 novembro201 novembro/201 n=65 n65 65 (n=65 <1 (< =1 1442 14,4±2, OR=4,3 OR43 (OR=4,3 IC9 796 2,796,7 27967 279 2,7 672 6,7 7 2,79-6,7 OR=1,8 OR18 (OR=1,8 12128 1,21–2,8 OR=1,5 OR15 (OR=1,5 10921 1,09–2,1 0 OR=3,6 OR36 (OR=3,6 1,51–8,5 15185 OR=3,9 OR39 9 (OR=3,9 126125 1,26–12,5 OR=1,7 OR17 (OR=1,7 1.13–2.6 11326 dezembro20 20 dezembro/2 novembro20 novembro/20 n=6 n6 (n=6 < ( = 144 14,4±2 OR=4, OR4 (OR=4, 2,796, 2796 27 2, 67 6, 2,79-6, OR=1, OR1 (OR=1, 1212 1,21–2, 1092 1,09–2, OR=3, OR3 (OR=3, 1,51–8, 1518 12612 1,26–12, 1.13–2. 1132 dezembro2 dezembro/ novembro2 novembro/2 n= (n= 14,4± OR=4 (OR=4 2,796 2,79-6 OR=1 (OR=1 121 1,21–2 109 1,09–2 OR=3 (OR=3 1,51–8 151 1261 1,26–12 1.13–2 113 novembro/ (n 14,4 OR= (OR= 2,79- 1,21– 10 1,09– 1,51– 15 126 1,26–1 1.13– 11 14, (OR 1,21 1,09 1,51 1,26– 1.13 1,2 1,0 1,5 1,26 1.1 1, 1.

Abstract Prognostic factors for local recurrence in patients with rectal cancer submitted to neoadjuvant chemoradiotherapy and total mesorectal excision. Background: The standard curative treatment for locally advanced rectal cancer of the middle and lower thirds is long-course chemoradiotherapy followed by total mesorectal excision. Purpose: To evaluate the prognostic factors associated with local recurrence in patients with rectal cancer submitted to neoadjuvant chemoradiotherapy and total mesorectal excision. Methods: Retrospective study including patients with rectal cancer T3–4N0M0 or T (any)N + M0 located within 10 cm from the anal border, or patients with T2N0M0 located within 5 cm, treated by long course chemoradio-therapy followed by total mesorectal excision with curative intent. Clinical, demographic, radiologic, surgical, and anatomopathological data were collected. Local recurrence was estimated using the Kaplan-Meier function, and risk was estimated according to each characteristic using univariate and multivariate analyses. Results: 270 patients were included, 57.8% male and mean age 61.7 (30‒88) years. At initial staging, 6.7% of patients were stage I, 21.5% stage II, and 71.8% stage III. Open surgery was performed in 65.2%, with sphincter preservation in 78.1%. Mortality within 30 postoperative days was 0.7%. After 49.4 (0.5‒86.1) months of median follow-up, overall and local recurrences were 26.3% and 5.9%. On multivariate analyses, local recurrence was associated with involvement of the mesorectal fascia on restaging MRI (HR = 9.11, p = 0.001) and with pathologic involvement of radial surgical margin (HR = 8.19, p < 0.001). Conclusion: Local recurrence of rectal cancer treated with long-course chemoradiation and total mesorectal excision is low and is associated with pathologic involvement of the radial surgical margin and can be predicted on restaging MRI. Background longcourse Purpose Methods T34N0M0 TNM T3 4N0M0 N M T3–4N0M anyN any 1 border T2N0M chemoradio therapy intent Clinical demographic radiologic collected KaplanMeier Kaplan Meier function analyses Results 27 included 578 57 8 57.8 617 61 7 61. 30‒88 3088 88 (30‒88 years staging 67 6 6.7 I 215 21 21.5 II 718 71 71.8 III 652 65 2 65.2% 781 78 78.1% 3 07 0 0.7% 494 49 4 49. 0.5‒86.1 05861 86 (0.5‒86.1 followup, followup follow up, up follow-up 263 26 26.3 59 9 5.9% HR 911 11 9.11 0.001 0001 001 819 19 8.19 0.001. . Conclusion T34N0M NM 4N0M 57. 30‒8 308 (30‒8 6. 21. 71. 65.2 78.1 0.7 0.5‒86. 0586 (0.5‒86. 26. 5.9 91 9.1 0.00 000 00 81 8.1 30‒ (30‒ 65. 78. 0. 0.5‒86 058 (0.5‒86 5. 9. 0.0 8. (30 0.5‒8 05 (0.5‒8 (3 0.5‒ (0.5‒ ( 0.5 (0.5 (0. (0

Resumen: Introducción: La enfermedad de Parkinson (EP) es un trastorno neurológico y progresivo caracterizado por síntomas motores y no motores que influyen en el deterioro de la calidad de vida. Objetivo: Esta investigación tiene como objetivo analizar los efectos de un programa de intervención multicomponente basado en la actividad física y el deporte en la funcionalidad de personas con EP, tanto con alta como con baja afectación. Metodología: Para ello, 16 personas (13 hombres y 3 mujeres) con EP participaron en este estudio, dividiéndose en 2 grupos según su nivel de afectación, el de baja (GBA, n = 12) y el de alta (GAA, n = 4). Se realizó una intervención de un programa de ejercicio físico multicomponente a todos los participantes durante 4 semanas (2 sesiones de 50 minutos, por semana). Se realizó una batería de test funcionales (Six minutes walk test (6MWT); Single-leg Stance test (SLS); Time Up and Go (TUG) y The five times sitto-stand Chair (FTSTS)) una semana antes (T1) y una semana después de la intervención (T2). Resultados: El total de la muestra mejoró significativamente en el test SLS (P < 0.05; d > 0.56, moderado). Sin embargo, analizando cada grupo, de conformidad con su nivel de afectación, el grupo GBA obtuvo mejoras significativas en SLS y 5STS (d= 0.44 - 0.68, p < 0.05), mientras que no se observaron diferencias significativas en el grupo GAA en ninguna variable analizada. Conclusiones: Los resultados del presente estudio muestran la necesidad de realizar más estudios con programas de larga duración y más frecuencia semanal.

Abstract: Introduction: Parkinson's disease (PD) is a progressive neurological disorder characterized by motor and non-motor symptoms that influence the impairment of quality of life. Objective: This research aims to analyze the effects of a multicomponent intervention program based on physical exercise and sport on the physiological functions of people with PD, both with high and low impairment. Methodology: For this purpose, sixteen people (13 men and 3 women) with PD participated in this study, divided into two groups according to their level of impairment, low (GBA, n = 12) and high (GAA, n = 4). A multicomponent physical exercise program intervention was administered to all participants for 4 weeks (2 sessions of 50 minutes per week). A battery of functional tests (Six minutes walk test (6MWT); Single-leg Stance test (SLS); Time Up and Go (TUG) and The five times sit-to-stand Chair (FTSTS)) was performed one week before (T1) and one week after the intervention (T2). Results: The total sample improved significantly on the SLS test (P < 0.05; d > 0.56, moderate). However, analyzing each group according to their level of impairment, the GBA group obtained significant improvements in SLS and 5STS (d= 0.44 - 0.68, P < 0.05), while no significant differences were observed in the GAA group in any of the variables analyzed. Conclusion: The results of the present study show the need for further studies with longer duration and more frequent weekly programs.

Resumo: Introdução: A doença de Parkinson (DP) é um distúrbio neurológico progressivo, caracterizado por sintomas motores e não motores que influenciam a deterioração da qualidade de vida. Objetivo: Esta pesquisa visa analisar os efeitos de um programa de intervenção multicomponente baseado na atividade física e no esporte sobre a funcionalidade das pessoas com DP, tanto com deficiência alta quanto baixa. Metodologia: Para este fim, 16 pessoas (13 homens e 3 mulheres) com DP participaram deste estudo, divididos em dois grupos de acordo com seu nível de afecção, o baixo (GBA, n = 12) e o alto (GAA, n = 4). Uma intervenção de um programa de exercícios físicos multicomponentes foi realizada com todos os participantes durante 4 semanas (2 sessões de 50 minutos por semana). Uma bateria de testes funcionais (Six minutes walk test (6MWT); Single-leg Stance test (SLS); Time Up and Go (TUG) y The five times sit-to-stand Chair (FTSTS)) foi realizada uma semana antes (T1) e uma semana após a intervenção (T2). Resultados: A amostra total melhorou significativamente no teste SLS (P < 0,05; d > 0,56, moderado). Não obstante, analisando cada grupo de acordo com seu nível de deficiência, o grupo GBA obteve melhorias significativas no SLS e 5STS (d= 0,44 - 0,68, p < 0,05), mas não se observaram diferenças significativas no grupo GAA em nenhuma variável analisada. Conclusões: Os resultados do presente estudo mostram a necessidade de mais estudos com programas de maior duração e mais frequência semanal.

Resumen El almidón resistente (AR) es una fracción del almidón no digerible por las α-amilasas y a diferencia de la fibra dietética, el AR es fermentado en el colon promoviendo beneficios en la salud. Dentro de los diferentes tipos de AR, el tipo 3 (AR3) se obtiene por autoclaveado y sin el uso de agentes químicos. El objetivo de este estudio fue obtener AR3 a partir de avena y evaluar su efecto a diferentes concentraciones (0, 5, 10, 15 y 20 %, p/p) sobre las propiedades reológicas de la masa, propiedades de textura de las galletas y su aceptabilidad sensorial. El análisis de perfil de textura (TPA) evidenció un incremento en la fracturabilidad, dureza, adhesividad y gomosidad. La incorporación de AR3 incrementó el módulo elástico (G´) y viscoso (G´´) en comparación con la masa control. Todos los tratamientos presentaron comportamiento elástico (G´ > G´´). La dureza en las galletas aumentó con la concentración de AR3, con valores de ≈ 8 N (control) hasta 20 N (AR3-20 %). Las pruebas sensoriales no fueron significativas entre tratamientos, aunque las galletas AR3-20 % tuvieron mayor preferencia. La adición de AR3 en la masa provocó cambios funcionales y de textura significativos que afectaron positivamente los atributos de calidad de las galletas.

Abstract Resistant starch (RS) is a portion of starch that is not digestible by α-amylases and unlike dietary fiber, RS is fermented in the colon, promoting health benefits. Among the different types of RS, type 3 (RS3) is obtained by autoclaving and without chemical agents. The objective of this work was to obtain RS3 from oats and to evaluate its effect at different concentrations (0, 5, 10, 15 and 20 % w/w) on the rheological properties of the dough, textural properties of the cookies and their sensory acceptability. Texture profile analysis (TPA) showed an increased fracturability, hardness, adhesiveness and gumminess. The incorporation of RS3 increased the elastic (G’) and viscous (G’’) modulus compared to the control dough. All treatments showed elastic behavior (G’ > G’’). Hardness in cookies increased with RS3 concentration, with values from ≈ 8 N (control) to 20 N (RS3 - 20 %). Sensory tests were not significant between treatments, although RS3-20 % cookies had a higher preference. The addition of RS3 in the dough caused significant functional and textural changes that positively affected the quality attributes of the cookies.

Abstract Introduction: The COVID-19 pandemic led to massive use of personal protective equipment (PPE). However, evidence on the frequency of appropriate use is sparse. In this study, we evaluated the level of knowledge about COVID-19 and biosafety measures, and the frequency of correct use of masks in workers at a university in Lima, Peru. Methods: Cross-sectional study conducted in a population of 109 workers of a private university who were physically onsite. We used a structured questionnaire to measure knowledge of COVID-19, together with use of and training in PPE. In addition, we explored factors associated with the correct use of masks and an adequate level of knowledge about COVID-19 and related biosafety measures. Results were expressed as prevalence, using student’s T-test and Pearson chi-square tests. Results: We evaluated 82 workers, 35.4% of whom showed an adequate level of knowledge about COVID-19 and biosafety measures. Younger participants and those who regularly washed their hands at work had an adequate level of knowledge, with 90.2% of these reporting correct use of their masks. Workers in general service areas or with a low level of education reported less frequent correct use of their mask compared to those who did not have these characteristics. Conclusion: We found a low level of knowledge about COVID-19 and biosafety measures among the workers of a private university; a higher level of education was associated with a greater prevalence of correct mask use. Training programs by work areas are needed, to improve biosafety practices among workers.

Resumen Introducción: La pandemia por la COVID-19 llevó al uso masivo de equipos de protección individual (EPI). Sin embargo, la evidencia sobre la frecuencia de su uso adecuado es escasa. El objetivo de este estudio es evaluar el nivel de conocimiento sobre la COVID-19 y medidas de bioseguridad, y la frecuencia de uso correcto de mascarilla en los trabajadores de una universidad en Lima, Perú, durante la pandemia. Métodos: Estudio transversal realizado en los 109 trabajadores de una universidad privada que se encontraban en modalidad presencial entre junio y septiembre 2021. Se utilizó un cuestionario estructurado sobre el conocimiento sobre la COVID-19, uso y capacitación en EPI, y posibles factores asociados al uso correcto de la mascarilla. Se estimaron las prevalencias del nivel de conocimiento y uso correcto de EPIs, y los factores asociados mediante la T student y Chi-2 de Pearson. Resultados: Participaron en total 82 trabajadores (75%). El 35% mostró un adecuado nivel de conocimiento sobre la COVID-19 y medidas de bioseguridad. Los más jóvenes y los que se lavaban las manos en el trabajo mostraron un mayor conocimiento, refiriendo el 90% utilizar correctamente su mascarilla. Los trabajadores de áreas de servicios generales o con bajo nivel de educación refirieron un menor uso correcto de su mascarilla. Conclusión: El nivel de conocimiento sobre la COVID-19 y las medidas de bioseguridad entre los trabajadores de una universidad privada fue bajo y el nivel de educación se mostró inversamente asociado al uso correcto de mascarilla. Es necesario implementar programas de capacitación por áreas de trabajo para mejorar las prácticas de bioseguridad en los trabajadores.

RESUMEN En Argentina, nitrógeno (N) y fósforo (P) y recientemente azufre (S) y cinc (Zn) son nutrientes reconocidos como limitantes de la producción de los cereales de invierno. Las decisiones de manejo de la fertilización en avena (Avena sativa L.), cebada (Hordeun vulgare L.) y trigo (Triticum aestivum L.) se realiza considerando aportes individuales de nutriente desconociendo la contribución combinada de elementos. La aplicación combinada de nutrientes mejoraría la respuesta a la fertilización comparada con el aporte individual de los elementos requiriendo su inclusión en los planteos o estrategias de manejo de la fertilización de cereales de invierno. El objetivo fue cuantificar los aportes a la producción de granos de avena, de cebada y de trigo de aplicar P, N, S, y Zn en forma individual y su relación con el uso combinado como NP y NPSZn. En 3 sitios (Tandil, San Manuel y Lobería, Argentina) y en tres cultivos (Trigo, Cebada y Avena) se realizaron experimentos de fertilización considerando aportes individuales y combinados de P, N, S y Zn. La fertilización combinada incorporando P, N, S y Zn presentó rendimientos mayores respec-to a los efectos individuales de estos nutrientes en trigo y en cebada. Los incrementos de rendimientos atribuidos a la diferencia entre la fertilización combinada sobre la suma de los efectos de fertilización individual fueron de 330 kg ha-1 en trigo y de 352 kg ha-1 en cebada. En avena, los datos disponibles no permiten determinar diferencias entre la fertilización combinada y los aportes individuales de cada nutriente. Para las condiciones evaluadas tanto en trigo como en cebada, en la decisión de fertilización con P-N-S-Zn, las fertilizaciones combinadas capturan respuestas de rendimientos adicionales a lo logrado en las respuestas a los nutrientes individuales.

ABSTRACT In Argentina, nitrogen (N) and phosphorus (P) and recently sulfur (S) and zinc (Zn) are recognized nutrients that limit the production of winter cereals. Fertilization decisions are made considering individual nutrient contributions, ignoring the combined contribution of elements. The combined application of nutrients would improve crops response to fertilization compared to the individual contribution of the elements. The objec-tive was to quantify the contributions to the production of oat (Avena sativa L.), barley (Hordeun vulgare L.) and wheat (Triticum aestivum L.) grains from either individual application of P, N, S, and Zn, or the combined use as NP and NPSZn. Fertilization experiments were carried out at three sites (Tandil, San Manuel and Lo-bería) in Argentina. Combined fertilization (NPSZn) resulted in greater yields than the that obtained with the nutrients applied alone in both wheat and barley. The yield advantage of the combined fertilization over the sum of individual fertilization effects was 330 kg ha-1 in wheat and 352 kg ha-1 in barley. In oats, the available data do not allow determining difference between individual or combined fertilization strategies. Under the conditions of this study, combined fertilization promote additional yield responses in both wheat and barley compared to that achieved with individual nutrient application.

RESUMEN Introducción: El Síndrome de Burnout es considerado una fatiga generalizada de la persona, se acompaña de agotamiento que produce decepción, pérdida de interés en la actividad laboral que desarrolla. Objetivo: Determinar la prevalencia del Síndrome de Burnout en estudiantes de 8vo semestre Clínica V de la Facultad de Odontología de la Universidad de Las Américas. Materiales y métodos: investigación descriptiva, comparativa, prospectiva y transversal, muestra de 69 alumnos; se utilizó test de Maslash Burnout Inventory para evaluación; test de signos y síntomas para determinar prevalencia y severidad; se compara Síndrome con género, hora y tipo de tratamientos clínicos que realiza el estudiante. Resultados: Nivel de cansancio emocional alto 53,6%; despersonalización bajo 46,4%; realización personal medio 44,9%. Los estudiantes encuestados presentaron Burnout alto 14,5%; medio 82,6%, bajo 2,9%; pruebas de Chi cuadrado de Pearson, no logró determinar la significancia, resultados similares entre la variable de género, tratamientos realizado y hora; en Síndrome con signos y síntomas, se determinaron algunas patologías: insomnio parcial, cefaleas; mialgias, dolor en cuello, dolor en extremidades superiores e inferiores, flatulencias, gastritis, presencia de nauseas, vómito. Conclusiones: el Síndrome de Burnout se presenta en ambos géneros, independiente de hora y acción clínica que realiza el estudiante.

ABSTRACT Introduction: Burnout Syndrome (SB)* is considered a generalized fatigue of the person, is accompanied by exhaustion that causes disappointment, loss of interest in the work activity that develops. Objective: Determine the prevalence of Burnout Syndrome in students of 8 semester Clinical V of the Faculty of Dentistry of the University of the Americas. Methods: Descriptive, comparative, prospective and transversal study, sample of 69 students; Maslash Burnout Inventory test was used for evaluation; tests of signs and symptoms to determine prevalence and severity; it compares syndrome with gender, time and type of clinical treatments performed by the student. Results: High emotional fatigue level 53.6%; depersonalization under 46.4%; average staffing 44.9%. Students surveyed presented burnout high 14.5%; average 82.6% and low 2.9%; Pearson's Chi squared tests, failed to determine significance, the results were similar among the gender variable, treatments performed and hour; in Syndrome with signs and symptoms, some pathologies were determined: partial insomnia, headaches; myalgia's, neck pain, pain in upper and lower extremities, flatulence, gastritis, presence of nausea, vomiting. Conclusions: Burnout Syndrome is presented in both genres, independent of the time and clinical action that the student performs

ABSTRACT Little is known about how Brazilian dentists’ treatment decisions for proximal carious lesions are compared to current evidence-based recommendations, so better understanding is needed to close any potential evidence-practice gap. Objectives: This cross-sectional study aimed to quantify the evidence-practice gap about proximal carious lesions treatment and identify dentist factors associated with this evidence-practice gap. Methods: Brazilian dentists (n=214) from Araraquara, São Paulo State, “completed a questionnaire about their dentist and practice characteristics and a translated version of the “Assessment of Caries Diagnosis and Caries Treatment” from the U.S. National Dental Practice-Based Research Network. Five radiographic images of proximal carious lesions in low-risk and high-risk patient scenarios were used. Associations between treatment recommendations and lesion, dentist, and practice characteristics were tested for statistical significance (p<0.05). Results: Lesions confined to the enamel would be restored by 35% and 71% of dentists in the low-risk and high-risk patient scenarios, respectively, suggesting a substantial evidence-practice gap given that surgical intervention of enamel lesions is not consistent with current evidence. The lesion depth threshold to recommend a permanent restoration differed between the low-risk and high-risk patient scenarios (p<0.001). Specific dentist/practice characteristics (dentist gender, graduate of a public dental school, postgraduate training, use of caries risk assessment) were significantly associated with the evidence-practice gap, but the magnitude of these differences was not major Conclusion: A substantial evidence-practice gap in treatment of proximal carious lesions was found for the sample overall, even when clinical scenarios presented low-risk patients. Global strategies are needed to close this substantial evidence-practice gap. evidencebased evidence based evidencepractice Objectives crosssectional cross sectional Methods n=214 n214 n 214 (n=214 Araraquara State completed Assessment Treatment US U S U.S PracticeBased Practice Based Network lowrisk low highrisk high used p<0.05. p005 p p<0.05 . 0 05 (p<0.05) Results 35 71 respectively p<0.001. p0001 p<0.001 001 (p<0.001) dentistpractice gender school training assessment Conclusion overall patients n=21 n21 21 (n=21 p00 p<0.0 (p<0.05 3 7 p000 p<0.00 00 (p<0.001 n=2 n2 2 (n=2 p0 p<0. (p<0.0 (p<0.00 n= (n= p<0 (p<0. (n p< (p<0 (p< (p

RESUMO Pouco se sabe se as decisões de tratamento dos dentistas brasileiros para lesões cariosas proximais são comparadas às recomendações atuais baseadas em evidências, portanto, é necessário um melhor entendimento para fechar qualquer potencial lacuna entre a evidência e a prática. Purpose: Este estudo transversal teve como objetivo quantificar a lacuna entre a evidência e a prática na decisão de tratamento das lesões cariosas proximais e identificar os fatores associados a essa lacuna entre a evidência e a prática. Methods: Cirurgiões-dentistas brasileiros (n=214) de Araraquara, Estado de São Paulo, preencheram um questionário sobre suas características odontológicas e clínicas e uma versão traduzida do “Assessment of Caries Diagnosis and Caries Treatment” da U.S. National Dental Practice-Based Research Network. Cinco imagens radiográficas de lesões cariosas proximais em cenários de pacientes de baixo risco e alto risco foram usadas. Associações entre recomendações de tratamento e lesão, dentista e características da prática foram testadas (p<0,05). Results: As lesões confinadas ao esmalte seriam restauradas por 35% e 71% dos dentistas nos cenários de pacientes de baixo risco e alto risco, respectivamente, sugerindo uma lacuna entre a evidência e a prática substancial, dado que a intervenção cirúrgica das lesões do esmalte não é consistente com as evidências atuais. O limiar de profundidade da lesão para recomendar uma restauração permanente diferiu entre os cenários de pacientes de baixo risco e alto risco (p<0,001). Características específicas do dentista/prática (sexo do dentista, graduado em uma faculdade pública, pós-graduação, uso da avaliação de risco de cárie) foram significativamente associadas à lacuna entre a evidência e a prática, mas a magnitude dessas diferenças não foi importante. Conclusions: uma lacuna entre a evidência e a prática substancial na decisão de tratamento de lesões cariosas proximais foi encontrada para a amostra como um todo, mesmo quando os cenários clínicos apresentavam pacientes de baixo risco. Estratégias globais são necessárias para fechar essa lacuna entre a evidência e a prática. portanto Purpose Methods Cirurgiõesdentistas Cirurgiões n=214 n214 n 214 (n=214 Araraquara Paulo Assessment Treatment US U S U.S PracticeBased Practice Based Network usadas p<0,05. p005 p p<0,05 . 0 05 (p<0,05) Results 35 71 respectivamente p<0,001. p0001 p<0,001 001 (p<0,001) dentistaprática sexo pública pósgraduação, pósgraduação pós graduação, graduação pós-graduação cárie importante Conclusions todo n=21 n21 21 (n=21 p00 p<0,0 (p<0,05 3 7 p000 p<0,00 00 (p<0,001 n=2 n2 2 (n=2 p0 p<0, (p<0,0 (p<0,00 n= (n= p<0 (p<0, (n p< (p<0 (p< (p

ABSTRACT Objective: To determine the prevalence and analyze the variables associated with the use of pacifiers and/or bottles by infants up to 6 months of age. Material and Methods: Data on sociodemographic characteristics, intention to offer pacifier and bottle-feeding, pregnancy and breastfeeding (BF) variables were collected at baseline by interviews and a self-administered questionnaire among pregnant women in the 3rd trimester. After delivery, mother-baby binomials were followed by phone calls at the 1st, 3rd, and 6th months of the baby's life (n=467) to gather information on the type of delivery, baby’s gender, BF in the first hour of the newborn’s life, baby’s weight, mother’s return to work, and oral habits. Association analyses were performed using logistic regression models with a 5% significance level with the pacifier/bottle-feeding use as the outcome. Results: Most mothers (52.5%) reported their babies used bottle-feeding, 48.2% used pacifiers and 33.4% used both of them throughout the 6 months. Intention to offer pacifier and bottle-feeding was reported by 45.0% and 54.8% of the mothers at the 3rd trimester of the pregnancy, respectively. Not living in one’s own residence (OR=1.53; 95%CI: 1.05-2.24) and having the prenatal intention of offering a pacifier (OR=2.50; 95%CI: 1.63-3.83) to the baby were significantly associated with pacifier use. Variables significantly associated with bottle-feeding were mother’s return to work (OR=2.48; 95%CI: 1.54-3.97), baby’s lower birth weight (OR=1.58; IC95%: 1.07-2.33), and prenatal intention to offer bottle-feeding (OR=2.51; 95%CI 1.56-4.04). Conclusion: About half of the babies used pacifiers or were bottle-fed, which were associated with the mother’s prenatal intention to offer them to their babies and socioeconomic factors. Objective andor age Methods characteristics bottlefeeding, bottlefeeding bottle feeding, feeding (BF selfadministered self administered rd delivery motherbaby mother 1st st th babys s n=467 n467 n 467 (n=467 gender newborns newborn habits 5 pacifier/bottlefeeding pacifierbottlefeeding pacifier/bottle outcome Results 52.5% 525 52 (52.5% 482 48 2 48.2 334 33 4 33.4 450 45 0 45.0 548 54 8 54.8 respectively ones one OR=1.53 OR153 OR 1 53 (OR=1.53 95CI CI 95 1.052.24 105224 1.05 2.24 05 24 1.05-2.24 OR=2.50 OR250 50 (OR=2.50 1.633.83 163383 1.63 3.83 63 3 83 1.63-3.83 OR=2.48 OR248 (OR=2.48 1.543.97, 154397 1.54 3.97 , 97 1.54-3.97) OR=1.58 OR158 58 (OR=1.58 IC95% IC95 IC 1.072.33, 107233 1.07 2.33 07 1.07-2.33) OR=2.51 OR251 51 (OR=2.51 1.564.04. 156404 1.56 4.04 . 56 04 1.56-4.04) Conclusion bottlefed, bottlefed fed, fed bottle-fed factors n=46 n46 46 (n=46 pacifierbottle 52.5 (52.5 48. 33. 45. 54. OR=1.5 OR15 (OR=1.5 9 052 1.052.2 10522 105 1.0 224 2.2 1.05-2.2 OR=2.5 OR25 (OR=2.5 633 1.633.8 16338 163 1.6 383 3.8 1.63-3.8 OR=2.4 OR24 (OR=2.4 543 1.543.97 15439 154 1.5 397 3.9 1.54-3.97 IC9 072 1.072.33 10723 107 233 2.3 1.07-2.33 564 1.564.04 15640 156 404 4.0 1.56-4.04 n=4 n4 (n=4 52. (52. OR=1. OR1 (OR=1. 1.052. 1052 10 1. 22 2. 1.05-2. OR=2. OR2 (OR=2. 1.633. 1633 16 38 3. 1.63-3. 1.543.9 1543 15 39 1.54-3.9 1.072.3 1072 23 1.07-2.3 1.564.0 1564 40 4. 1.56-4.0 n= (n= (52 OR=1 (OR=1 1.052 1.05-2 OR=2 (OR=2 1.633 1.63-3 1.543. 1.54-3. 1.072. 1.07-2. 1.564. 1.56-4. (n (5 OR= (OR= 1.05- 1.63- 1.543 1.54-3 1.072 1.07-2 1.564 1.56-4 ( (OR 1.54- 1.07- 1.56-

Abstract Introduction Right colon diverticulitis (RCD) is an uncommon condition in Western populations, but its incidence has increased over the last decades. Due to its rarity, many surgeons are unfamiliar with this disease, which is often mistakenly diagnosed as acute appendicitis. The lack of data about the diagnosis and management of RCD in Western populations makes it difficult to establish the optimal therapeutic strategy. Objective To evaluate the outcomes of patients treated for acute RCD and to propose a therapeutic algorithm for the diagnosis and treatment. Methods A retrospective analysis of the medical records of patients treated for acute RCD between 2008 and 2020 by a single experienced colorectal surgeon was performed. Results In total, 12 patients were identified, 8 male and 4 female subjects, with a mean age of 49.6 years; 9 of these patients were of Western origin. The median follow-up time was of 49 months (range: 12 to 144 months). The most frequent symptoms were abdominal pain (100%) and fever (66%). Diagnostic errors in imaging exams occurred in four patients. A total of 6 patients were managed clinically, and the other 6 underwent surgical treatment with right colectomy (n = 5) and total colectomy (n = 1), 2 via laparoscopy and 4 through a laparotomy. The anatomopathological examination confirmed RCD in all operated patients. There was no incidental finding of neoplasia and there were no deaths during the study period. Conclusion Uncomplicated RCD can be treated conservatively with a high success rate. Recurrent cases that impact quality of life or complicated forms of RCD should undergo surgical treatment, preferably through a right laparoscopic colectomy. The authors present a diagnostic and therapeutic algorithm to facilitate the diagnosis and to guide the management of this uncommon disease. (RCD decades rarity disease appendicitis strategy 200 202 performed 1 identified subjects 496 49. years origin followup follow up range (range 14 months. . months) 100% 100 (100% 66%. 66 66% (66%) clinically n 5 1, , 1) laparotomy period rate 20 10 (100 (66% (10 (66 (1 (6 (

Abstract Objective: In this paper we study, from the seller’s perspective, how to auction a finite set of identical items when the buyer who obtains the whole set of goods (if any) gets a bonus, such that the seller maximizes his expected revenue and taking into account the strategic behavior of the bidders. Methodology: We use Bayesian Games for modelling the situation considering a strategy space equal to R + m for each bidder. Results: We show a Symmetric Bayesian Equilibrium for the model as well as the seller’s indifference between several natural ways for offering the bonus to a bidder getting the whole set of items, because he obtains the same expected revenue. Limitations: The model regards only identical items. Originality: We show an equilibrium bid for a n-personal model of m Simultaneous Auctions under first-price close mechanism considering that there is a kind of extra profit. Conclusions: The seller is indifferent between several ways to offer the bonus. It could be interesting to contrast the theoretical results under an experimental framework.

Resumen Objetivo: Estudiar, desde el punto de vista del vendedor, la manera de subastar un conjunto finito de bienes idénticos donde se otorga un cierto premio al postor que obtenga el conjunto completo de bienes, tomando en cuenta el comportamiento estratégico de los postores. Metodología: Se modela la situación como un juego bayesiano considerando el espacio de estrategias de cada jugador como R + m. Resultados: Se muestra un equilibrio bayesiano simétrico y se demuestra que el vendedor es indiferente entre algunas maneras de ofrecer la utilidad extra, al obtener el mismo rendimiento esperado. Limitaciones: El modelo soló considera el caso de bienes idénticos. Originalidad: Se encuentra la puja de equilibrio para un caso de m subastas simultáneas y n postores, bajo el mecanismo del primer precio considerando utilidad extra modeladas mediante juegos bayesianos. Conclusiones: Los cambios en el rendimiento esperado del vendedor no son sensibles ante algunas maneras de otorgar el incentivo.

Abstract Background The Parkinson disease (PD) is frequently associated with autonomic dysfunctions. However, data regarding the influence of PD on the autonomic responses to postural changes is limited. Objective To analyze and compare the autonomic responses, evaluated through linear and non-linear methods of heart rate variability, and cardiorespiratory parameters in two groups: Parkinson disease (PDG) and control (CG), at rest and during the active tilt test. Methods A total of 48 participants were analyzed (PDG: n = 25;73.40 ± 7.01 years / CG: n = 23;70.17 ± 8.20 years). The autonomic modulation and cardiorespiratory parameters were evaluated at rest and during the active tilt test. To assess the autonomic modulation the linear indices, at the time (rMSSD, SDNN) and frequency (LF, HF, LF/HF) domains, and the non-linear indices, obtained through the Poincaré plot (SD1, SD2, SD1/SD2), were calculated. The cardiorespiratory parameters evaluated were heart rate (HR), systolic (SBP), and diastolic blood pressure (DBP), peripheral oxygen saturation (SpO2), and respiratory rate. Results At rest, the PDG presented significantly lower values of rMSSD, SDNN, LF, HF, SD1, SD2, and DBP, and higher values of SpO2. During test, in the PD group, modifications were observed in HR, and SBP, besides a reduced parasympathetic response, and an increased global modulation. The qualitative analysis of the Poincaré plot showed that the PDG has a lower dispersion of the RR intervals during rest and the active tilt test. Conclusion Individuals with PD present reduced global variability and parasympathetic modulation at rest, and reduced parasympathetic response and damage in HR regulation when performing the active tilt test, compared with controls. (PD dysfunctions However limited nonlinear non groups (PDG CG, CG , (CG) test 4 2573.40 257340 25 73.40 73 40 25;73.4 701 7 01 7.0 2370.17 237017 23 70.17 70 17 23;70.1 820 8 20 8.2 years. . years) indices rMSSD (rMSSD SDNN LF (LF HF LF/HF LFHF domains SD1 SD (SD1 SD2 SD1/SD2, SD1SD2 SDSD SD1/SD2 SD1/SD2) calculated (HR) SBP (SBP) DBP (DBP) SpO2, SpO2 SpO (SpO2) group controls (CG 2573 2573.4 25734 2 7340 73.4 25;73. 0 7. 2370 2370.1 23701 7017 70.1 1 23;70. 82 8. (SD SD1SD SD1/SD (HR (SBP (DBP (SpO2 257 2573. 734 73. 25;73 237 2370. 70. 23;70 (SpO 25;7 23;7 25; 23;

Resumo Antecedentes A doença de Parkinson (DP) está frequentemente associada a disfunções autonômicas. Porém, dados sobre a influência da DP nas respostas autonômicas às mudanças posturais são limitados. Objetivos Analisar e comparar as respostas autonômicas, avaliadas por métodos lineares e não lineares de variabilidade da frequência cardíaca e parâmetros cardiorrespiratórios em dois grupos: DP (GDP) e controle (CG), em repouso e durante o tilt test ativo. Métodos Foram analisados 48 participantes (GDP: n = 25;73,40 ± 7,01 anos/GC: n = 23; 70,17 ± 8,20 anos). A modulação autonômica e os parâmetros cardiorrespiratórios foram avaliados em repouso e durante o tilt test ativo. Para avaliar a modulação autonômica foram calculados os índices lineares, nos domínios do tempo (rMSSD, SDNN) e frequência (LF, HF, LF/HF), e os índices não lineares, obtidos através do plot de Poincaré (SD1, SD2, SD1/SD2). Os parâmetros cardiorrespiratórios avaliados foram frequência cardíaca (FC), pressão arterial sistólica (PAS), diastólica (PAD), saturação periférica de oxigênio (SpO2) e frequência respiratória. Resultados Em repouso, o GDP apresentou valores menores de rMSSD, SDNN, LF, HF, SD1, SD2 e PAD, e maiores valores de SpO2. No teste, foram observadas modificações na FC e na PAS, redução da resposta parassimpática e aumento da modulação global no GDP. A análise qualitativa do plot de Poincaré mostrou que o GDP apresentou menor dispersão dos intervalos RR no repouso e no tilt test ativo. Conclusão Indivíduos com DP apresentam redução da variabilidade global e modulação parassimpática em repouso, redução da resposta parassimpática e prejuízo na regulação da FC ao realizar o tilt test ativo, em comparação aos controles. (DP Porém limitados grupos (GDP CG, CG , (CG) ativo 4 2573,40 257340 25 73,40 73 40 25;73,4 701 7 01 7,0 anos/GC anosGC anos GC 23 7017 70 17 70,1 820 8 20 8,2 anos. . anos) rMSSD (rMSSD SDNN LF (LF HF LF/HF, LFHF LF/HF LF/HF) SD1 SD (SD1 SD1/SD2. SD1SD2 SDSD SD1/SD2 SD1/SD2) FC, (FC) PAS (PAS) PAD (PAD) SpO2 SpO (SpO2 respiratória teste controles (CG 2573 2573,4 25734 2 7340 73,4 25;73, 0 7, 1 70, 82 8, (SD SD1SD SD1/SD (FC (PAS (PAD (SpO 257 2573, 734 73, 25;73 25;7 25;

Abstract Objective: To estimate and compare the levels of empathy between undergraduate dentistry students and professors at a university in the Dominican Republic. Material and Methods: Cross-sectional and descriptive study. The studied population consisted of two groups. The first: students of the Dentistry Career (N=520; n=335: 64.42% of total students) were distributed in two areas, basic-preclinical and clinical, while the second group corresponded of teachers who work in both areas (N=92; n=56; 60.87% of all teachers). The total sample was n = 391. The Jefferson Scale of Physician Empathy (S-Version) was used. Reliability was estimated using Cronbach's α and intraclass correlation coefficient, descriptive statistics, two-way analysis of variance, Tukey's test, effect size, and power of the test. Significance level: α≤0.05 and β≤0.20. Results: The empathy and dimension values were, in general, higher in the professors of the clinical area in relation to the other areas studied, with the exception of the compassionate care dimension. Conclusion: The finding that clinical teachers have a greater value of empathy is potentially an advantage for training students, especially in the clinical area.

BACKGROUND High-risk human papillomaviruses (HR-HPVs) are the etiological agents of cervical cancer. Among them, types 16 and 18 are the most prevalent worldwide. The HPV genome encodes three oncoproteins (E5, E6, and E7) that possess a high transformation potential in culture cells when transduced simultaneously. In the present study, we analysed how these oncoproteins cooperate to boost key cancer cell features such as uncontrolled cell proliferation, invasion potential, and cellular redox state imbalance. Oxidative stress is known to contribute to the carcinogenic process, as reactive oxygen species (ROS) constitute a potentially harmful by-product of many cellular reactions, and an efficient clearance mechanism is therefore required. Cells infected with HR-HPVs can adapt to oxidative stress conditions by upregulating the formation of endogenous antioxidants such as catalase, glutathione (GSH), and peroxiredoxin (PRX). OBJECTIVES The primary aim of this work was to study how these oncoproteins cooperate to promote the development of certain cancer cell features such as uncontrolled cell proliferation, invasion potential, and oxidative stress that are known to aid in the carcinogenic process. METHODS To perform this study, we generated three different HaCaT cell lines using retroviral transduction that stably expressed combinations of HPV-18 oncogenes that included HaCaT E5-18, HaCaT E6/E7-18, and HaCaT E5/E6/E7-18. FINDINGS Our results revealed a statistically significant increment in cell viability as measured by MTT assay, cell proliferation, and invasion assays in the cell line containing the three viral oncogenes. Additionally, we observed that cells expressing HPV-18 E5/E6/E7 exhibited a decrease in catalase activity and a significant augmentation of GSH and PRX1 levels relative to those of E5, E6/E7, and HaCaT cells. MAIN CONCLUSIONS This study demonstrates for the first time that HPV-18 E5, E6, and E7 oncoproteins can cooperate to enhance malignant transformation.

La evaluación del perfil epidemiológico del Síndrome Metabólico en población general usando la metodología WHO-STEPS de la Organización Mundial de la Salud es incipiente o nula en muchos países Latino Americanos. Objetivo: caracterizar el perfil epidemiológico del Síndrome Metabólico y sus factores de riesgo asociados en población general mayor de 18 años en la ciudad de Cochabamba, Bolivia, durante la gestión II-2016. Métodos: se realizó un estudio observacional, analítico de corte transversal, en población general de 18 o más años, con una muestra de n=186 sujetos ajustados por grupo etario y sexo en base a la pirámide poblacional de Cochabamba-Bolivia. Se aplicó la metodología STEPS (pasos) de la OPS/OMS para la recolección de la información centrada en datos sociodemográficos, hábitos de vida, evaluación física y laboratorial. Se calcularon proporciones e intervalos de confianza al 95% conforme lo establecido en el manual de implementación de la metodología STEP; y regresión logística multivariada para la obtención del OR ajustado para el nivel de riesgo asociados al Síndrome Metabólico. Resultados: la prevalencia global de Síndrome metabólico fue de 44,1%; la prevalencia de sus factores de riesgo asociados fue: STEP-1, Tabaquismo 11,29%; consumo actual de alcohol 63,44%; bajo consumo de frutas y vegetales 76,88%; sedentarismo o bajo nivel de actividad física 75,81%. STEP-2: sobrepeso 44,62%; obesidad 24,73%; obesidad abdominal 38,7% y presión arterial elevada en 35,14%. STEP3: Glicemia alterada en ayunas 36,02%; Insulina basal alterada 36,56%; colesterol total elevado 36,02%; Triglicéridos elevados 46,77% y HDL-colesterol reducido en el 66,67%. Los niveles de OR ajustado fueron >1 y estadísticamente significativas para las medidas físicas y laboratoriales. Conclusión: el síndrome metabólico en altamente prevalente en la población general de la ciudad de Cochabamba y se asocia a niveles elevados de IMC, presión arterial elevada y perfil laboratorial alterado.

The epidemiological profile evaluation of Metabolic Syndrome in the general population using the WHO-STEPS approach of the World Health Organization is incipient or null in many Latin American countries. Objective: to characterize the epidemiological profile of Metabolic Syndrome and risk factors associated in the general population over 18 years of age in Cercado-Cochabamba city, from Bolivia, during the second semester of 2016. Methods: an observational, analytical, cross-sectional study was conducted in the general population of 18 years of age or older, with a sample of n = 186 subjects adjusted by age group and sex based on the population pyramid of Cochabamba-Bolivia. WHO-STEPS approach was applied for the collection of information focused on sociodemographic data, life habits, physical and laboratory evaluation. Proportions and 95% confidence intervals were calculated as established in the STEP´ implementation manual, and multivariate logistic regression was calculated to obtain adjusted OR for the level of risk associated with Metabolic Syndrome. Results: the overall prevalence of metabolic syndrome was 44.1%; the prevalence of risk factors associated were: STEP-1, Smoking 11.29%; current alcohol consumption 63.44%; low consumption of fruits and vegetables 76.88%; sedentary lifestyle or low level of physical activity 75.81%. STEP-2: overweight 44.62%; obesity 24.73%; abdominal obesity 38.7% and high blood pressure 35.14%. STEP3: Hyperglycemia in 36.02%; basal insulin elevated 36.56%; total cholesterol 36.02%; Triglycerides elevated 46.77% and HDL-cholesterol reduced in 66.67%. Conclusion: metabolic syndrome is highly prevalent in the general population in Cochabamba City and is associated with high levels of BMI, high blood pressure high values of the laboratorial profile.