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Abstract Objectives Our study aimed to verify the evidence of auditory training employed in the audiological treatment of tinnitus in adults and older adults. Methods Scoping review based on a search for articles in journals available in MEDLINE (PubMed), Embase (Elsevier), LILACS (BVS), and Cochrane Library. Titles and abstracts of the retrieved articles were assessed by peers, following the eligibility criteria; they were afterward read in full text, and the references were hand searched in the results found. Studies’ level of evidence was classified into very high (Level A+), high (Level A), moderate (Level B), limited (Level C), low (Level D), or very low (Level D−) based on the Critically Appraised Topics. Results 2160 records were identified in the searching stage and 15 studies were eligible for data extraction. Study design, sample characterization, auditory training tasks, sound stimuli, outcome measures, and results were extracted. Frequency discrimination training was the most frequent strategy, followed by auditory attentional skills training and multisensory training. Almost all studies with daily auditory training sessions reported significant benefits demonstrated in at least one outcome measure. Studies that used auditory discrimination training and attentional auditory skill stimulation to treat tinnitus obtained quality evidence levels ranging from limited to high (C‒A) and studies that applied multisensory training or attentional training combined with counseling and passive listening in tinnitus patients reached a high-quality evidence level (A). Conclusion Recent studies had higher levels of evidence and considered attentional factors and multisensory pathways in auditory training strategies. PubMed, PubMed , (PubMed) Elsevier, Elsevier (Elsevier) BVS, BVS (BVS) Library peers criteria text found Level A+, A A+ A+) A, A) B, B B) C, C C) D, D D) D− Topics 216 1 extraction design characterization tasks stimuli measures extracted strategy measure C‒A CA (C‒A highquality A. . (A) strategies (PubMed (Elsevier (BVS 21 (A 2

https://doi.org/10.1016/j.bjorl.2023.101361

Autumn Cover Crops Increase Deep Root Growth of Soybean in no-Tillage System noTillage no Tillage
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Koszalka, Victória

; Camilo, Edson Lucas

; Surkamp, Carolina

; Rampim, Leandro

; Pott, Cristiano Andre

; Müller, Marcelo Marques Lopes

Brazilian Archives of Biology and Technology

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2024, Volume 67 Nº spe1 elocation e24230805

Resumo: En | Texto: En | PDF: En

Abstract Root growth is crucial in crop production and is influenced by soil attributes, but also affects soil chemical, physical and biological quality, along with management and conservation practices. In this paper, soybean root growth data from a field study at Guarapuava, Paraná State, Brazil are examined. In 2019, at a farm with over 35 years of no-tillage system (NT) adoption, three management sets were established in 1,1 ha macroplots: 1) farmer's NT standard (FNT), without terraces, with downhill farming and with autumn fallow; 2) autumn cover crops and contour farming added to FNT, as best management practices (BMP); 3) terraces and contour farming (TC) added to FNT. Soybean was sowed in November 2020 and 2021, and minirhizotron tubes (1 m long, 7 cm wide) were installed into the soil just after soybean emerged in 2020. Root length, area, volume, and diameter were evaluated with the help of a root scanner. Data were submitted to descriptive statistics. The added conservation practices improved root length, area and volume, significantly for BMP in the subsoil (40-60 cm) compared to FNT standard. Minirhizotron enabled the study of roots in the field, but data variability was high, so that for annual crops with pivoting roots like soybean, root observation points (6 per plot) must be increased, and crop stand close to the observation points is a critical font of error. attributes chemical quality paper Guarapuava State examined 2019 3 notillage no tillage (NT adoption 11 1 1, macroplots farmers farmer s , (FNT) fallow 2 (BMP) TC (TC 202 2021 ( long wide length volume scanner statistics 4060 40 60 (40-6 high 6 plot increased error 201 (FNT (BMP 20 406 4 (40- (40 (4

https://doi.org/10.1590/1678-4324-pssm-2024230805

Mortality and years of life lost related to adverse drug events in Brazil
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Silva, Lunara Teles

; Modesto, Ana Carolina Figueiredo

; Oliveira, Rodrigo Alves de

; Amaral, Rita Goreti

; Lopes, Flavio Marques

Revista de Saúde Pública

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2024, Volume 58 elocation 20

Resumo: En | Texto: En | PDF: En

ABSTRACT OBJECTIVE To assess regional and national mortality and years of life lost (YLL) related to adverse drug events in Brazil. METHODS This is an ecological study in which death records from 2009 to 2018 from the Mortality Information System were analyzed. Codes from the International Classification of Diseases 10th revision (ICD-10) that indicated drugs as the cause of death were identified. The number of deaths and the YLL due to adverse drug events were obtained. Crude, age- and gender-specific, and age-adjusted mortality rates and YLL rates per 100,000 inhabitants were formed by year, age group, gender, and Brazilian Federative Unit. Rate ratios were calculated by comparing rates from 2009 to 2018. A joinpoint regression model was applied for temporal analysis. RESULTS For the selected ICD-10 codes, a total of 95,231 deaths and 2,843,413 YLL were recorded. Mortality rates from adverse drug events increased by a mean of 2.5% per year, and YLL rates increased by 3.7%. Increases in rates were observed in almost all age groups for both genders. Variations in rates were found between Federative Units, with the highest age-adjusted mortality and YLL rates occurring in the Distrito Federal. CONCLUSIONS The numbers and rates of deaths and YLL increased during the study period, and variations in rates of deaths and YLL were observed between Brazilian Federative Units. Information on multiple causes of death from death certificates can be useful for quantifying adverse drug events and analyzing them geographically, by age and by gender. (YLL Brazil 200 201 analyzed th ICD10 ICD 10 (ICD-10 identified obtained Crude genderspecific, genderspecific gender specific, specific gender-specific ageadjusted adjusted 100000 100 000 100,00 year group Unit analysis ICD-1 codes 95231 95 231 95,23 2843413 2 843 413 2,843,41 recorded 25 5 2.5 37 3 7 3.7% genders Units Federal period geographically 20 ICD1 1 (ICD-1 10000 00 100,0 ICD- 9523 9 23 95,2 284341 84 41 2,843,4 2. 3.7 (ICD- 1000 0 100, 952 95, 28434 8 4 2,843, 3. (ICD 2843 2,843 284 2,84 28 2,8 2,

https://doi.org/10.11606/s1518-8787.2024058005458

Fatores associados à capacidade funcional em pessoas idosas no serviço de emergência
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Souza, Lidia Ferreira de

; Santos, Eilane Souza Marques dos

; Campanharo, Cássia Regina Vancini

; Lopes, Maria Carolina Barbosa Teixeira

; Okuno, Meiry Fernanda Pinto

; Torres, Gilson de Vasconcelos

; Nunes, Vilani Medeiros de Araújo

; Batista, Ruth Ester Assayag

Acta Paulista de Enfermagem

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2024, Volume 37 elocation eAPE00723

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

Abstract Objective To relate sociodemographic, economic and clinical variables and having or not having a caregiver, risk for falls and perception of the risk for falls with the functional capacity of older adults in an Emergency Department. Methods Analytical cross-sectional study of 197 older adults conducted in the Emergency Department between September 2019 and March 2020. A questionnaire with sociodemographic, economic and clinical information was applied, as well as the instruments: Falls Risk Awareness Questionnaire, Morse Falls Scale, Katz Index and Lawton Scale. The Kruskal Wallis test was used to compare the Katz Index and the Lawton Scale, and the Spearman correlation coefficient was used to associate the Morse Falls Scale with continuous variables. The Mann-Whitney test and the Kruskal Wallis test were used to associate the Falls Risk Awareness Questionnaire with the categorical variables. Results Illiterate patients (p<0.0001) with lower income (p=0.0446) had a lower score on the Katz Index, that is, they presented a higher percentage of totally dependent people. Divorced older adults (p=0.0004) without a caregiver (p<0.0001) had a higher score on the Lawton Scale, that is, a greater degree of independence. The greater perception of risk for falls (p=0.0403) was associated with less independence for instrumental activities of daily living. The low risk for falls (p<0.0001) was associated with greater independence for instrumental activities of daily living. There was no association between perceived risk for falls (p=0.2693) and risk for falls (p=0.4984) with the Katz Index. Conclusion Lower education and income were associated with dependence for activities of daily living. Being divorced and not having a caregiver were associated with independence in instrumental activities of daily living. There was no association between the perception of risk for falls and the risk for falls with activities of daily living. The greater perception of risk for falls was associated with less independence, and the low risk for falls was associated with greater independence for instrumental activities of daily living. sociodemographic crosssectional cross sectional 19 201 2020 applied instruments MannWhitney Mann Whitney p<0.0001 p00001 p 0 0001 (p<0.0001 p=0.0446 p00446 0446 (p=0.0446 is people p=0.0004 p00004 0004 (p=0.0004 p=0.0403 p00403 0403 (p=0.0403 living p=0.2693 p02693 2693 (p=0.2693 p=0.4984 p04984 4984 (p=0.4984 1 20 202 p<0.000 p0000 000 (p<0.000 p=0.044 p0044 044 (p=0.044 p=0.000 (p=0.000 p=0.040 p0040 040 (p=0.040 p=0.269 p0269 269 (p=0.269 p=0.498 p0498 498 (p=0.498 2 p<0.00 p000 00 (p<0.00 p=0.04 p004 04 (p=0.04 p=0.00 (p=0.00 p=0.26 p026 26 (p=0.26 p=0.49 p049 49 (p=0.49 p<0.0 p00 (p<0.0 p=0.0 (p=0.0 p=0.2 p02 (p=0.2 p=0.4 p04 4 (p=0.4 p<0. p0 (p<0. p=0. (p=0. p<0 (p<0 p=0 (p=0 p< (p< p= (p= (p

Resumen Objetivo Relacionar variables sociodemográficas, económicas, clínicas y tener o no tener cuidador, riesgo de caída y percepción del riesgo de caída con la capacidad funcional de personas mayores en un servicio de emergencia. Métodos Estudio transversal y analítico, realizado entre septiembre de 2019 y marzo de 2020 en un servicio de emergencia con 197 personas mayores. Se aplicó un cuestionario con información sociodemográfica, económica y clínica; y se aplicaron los siguientes instrumentos: Falls Risk Awareness Questionnaire, Morse Falls Scale, Índice de Katz y Escala de Lawton. Para comparar el Índice de Katz y la Escala de Lawton se utilizó la prueba de Kruskal Wallis, y para asociar la Morse Falls Scale con las variables continuas se utilizó el coeficiente de correlación de Spearman. Para asociar el Falls Risk Awareness Questionnaire con las variables categóricas se utilizó la prueba de Mann-Whitney y la prueba de Kruskal Wallis. Resultados Las personas no letradas (p<0,0001) y con menores ingresos (p=0,0446) tuvieron un puntaje menor en el Índice de Katz, es decir, presentaron un mayor porcentaje de totalmente dependientes. Los divorciados (p=0,0004) y sin cuidador (p<0,0001) presentaron mayor puntaje en la Escala de Lawton, es decir, mayor nivel de independencia. Una mayor percepción de los riesgos de caída (p=0,0403) se asoció a una menor independencia para las actividades instrumentales de la vida diaria. El bajo riesgo de caída (p<0,0001) se asoció a una mayor independencia para las actividades instrumentales de la vida diaria. No hubo asociación entre percepción del riesgo de caída (p=0,2693) y riesgo de caída (p=0,4984) con el Índice de Katz. Conclusión Una menor escolaridad y menores ingresos se asociaron con la dependencia para actividades de la vida diaria. Ser divorciado y no tener cuidador se asoció con la independencia para actividades instrumentales de la vida diaria. No hubo asociación entre la percepción del riesgo de caída y el riesgo de caída con las actividades de la vida diaria. Una mayor percepción de los riesgos de caída se asoció a una menor independencia y el bajo riesgo de caída se asoció a una mayor independencia para las actividades instrumentales de la vida diaria. sociodemográficas económicas analítico 201 202 19 sociodemográfica clínica instrumentos Wallis Spearman MannWhitney Mann Whitney p<0,0001 p00001 p 0 0001 (p<0,0001 p=0,0446 p00446 0446 (p=0,0446 decir dependientes p=0,0004 p00004 0004 (p=0,0004 p=0,0403 p00403 0403 (p=0,0403 diaria p=0,2693 p02693 2693 (p=0,2693 p=0,4984 p04984 4984 (p=0,4984 20 1 p<0,000 p0000 000 (p<0,000 p=0,044 p0044 044 (p=0,044 p=0,000 (p=0,000 p=0,040 p0040 040 (p=0,040 p=0,269 p0269 269 (p=0,269 p=0,498 p0498 498 (p=0,498 2 p<0,00 p000 00 (p<0,00 p=0,04 p004 04 (p=0,04 p=0,00 (p=0,00 p=0,26 p026 26 (p=0,26 p=0,49 p049 49 (p=0,49 p<0,0 p00 (p<0,0 p=0,0 (p=0,0 p=0,2 p02 (p=0,2 p=0,4 p04 4 (p=0,4 p<0, p0 (p<0, p=0, (p=0, p<0 (p<0 p=0 (p=0 p< (p< p= (p= (p

Resumo Objetivo Relacionar variáveis sociodemográficas, econômicas, clínicas e ter ou não cuidador, risco de queda e percepção do risco de quedas com a capacidade funcional em pessoas idosas em um Serviço de Emergência. Métodos Estudo transversal e analítico, realizado entre setembro de 2019 e março de 2020, no Serviço de Emergência, com 197 pessoas idosas. Foi aplicado questionário com informações sociodemográficas, econômicas e clínicas; e os instrumentos: Falls Risk Awareness Questionnaire, Morse Falls Scale, Índice de Katz e Escala de Lawton. Para comparar o Índice de Katz e a Escala de Lawton; e associar a Morse Falls Scale com as variáveis contínuas foram utilizados, respectivamente, o teste de Kruskal Wallis e o coeficiente de correlação de Spearman. Para associar Falls Risk Awareness Questionnaire com as variáveis categóricas utilizou-se o teste de Mann-Whitney e o teste de Kruskal Wallis. Resultados Os nãos letrados (p<0,0001) e com menor renda (p=0,0446) tiveram menor escore no Índice de Katz, isto é, apresentaram maior percentual de totalmente dependentes. Os divorciados (p=0,0004) e sem cuidador (p<0,0001) apresentaram maior escore na Escala de Lawton, ou seja, maior grau de independência. A maior percepção dos riscos de queda (p=0,0403) associou-se à menor independência para as atividades instrumentais de vida diária. O risco baixo de quedas (p<0,0001) associou-se à maior independência para as atividades instrumentais de vida diária. Não houve associação entre percepção do risco de queda (p=0,2693) e risco de queda (p=0,4984) com o Índice de Katz. Conclusão A menor escolaridade e renda associaram-se com a dependência para atividades de vida diária. Ser divorciado e não ter cuidador associaram-se com a independência para atividades instrumentais de vida diária. Não houve associação entre a percepção do risco de queda e o risco de queda com as atividades de vida diária. A maior percepção dos riscos de queda associou-se à menor independência e o risco baixo de quedas associou-se à maior independência para as atividades instrumentais de vida diária. sociodemográficas Emergência analítico 201 2020 19 instrumentos Lawton utilizados respectivamente Spearman utilizouse utilizou se MannWhitney Mann Whitney p<0,0001 p00001 p 0 0001 (p<0,0001 p=0,0446 p00446 0446 (p=0,0446 é dependentes p=0,0004 p00004 0004 (p=0,0004 seja p=0,0403 p00403 0403 (p=0,0403 associouse associou diária p=0,2693 p02693 2693 (p=0,2693 p=0,4984 p04984 4984 (p=0,4984 associaramse associaram 20 202 1 p<0,000 p0000 000 (p<0,000 p=0,044 p0044 044 (p=0,044 p=0,000 (p=0,000 p=0,040 p0040 040 (p=0,040 p=0,269 p0269 269 (p=0,269 p=0,498 p0498 498 (p=0,498 2 p<0,00 p000 00 (p<0,00 p=0,04 p004 04 (p=0,04 p=0,00 (p=0,00 p=0,26 p026 26 (p=0,26 p=0,49 p049 49 (p=0,49 p<0,0 p00 (p<0,0 p=0,0 (p=0,0 p=0,2 p02 (p=0,2 p=0,4 p04 4 (p=0,4 p<0, p0 (p<0, p=0, (p=0, p<0 (p<0 p=0 (p=0 p< (p< p= (p= (p

https://doi.org/10.37689/acta-ape/2024ao000723

Mortality and years of life lost related to adverse drug events in Brazil
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Silva, Lunara Teles

; Modesto, Ana Carolina Figueiredo

; Oliveira, Rodrigo Alves de

; Amaral, Rita Goreti

; Lopes, Flavio Marques

Revista de Saúde Pública

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2024, Volume 58 elocation 20

Resumo: En | Texto: En | PDF: En

https://doi.org/10.11606/s1518-8787.2024058005458

Parental body mass index and maternal gestational weight gain associations with offspring body composition in young women from the Nutritionists’ Health Study Nutritionists
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Freitas, Renata Germano Borges de Oliveira Nascimento

; Vasques, Ana Carolina Junqueira

; Ribeiro, Francieli Barreiro

; Solar, Isabela

; Hanada, Alfredo Shigueo

; Barbosa, Marina Gomes

; Valente, Angélica Marques Martins

; Pititto, Bianca de Almeida

; Eshriqui, Ilana

; Lopes, Tito Lívio da Cunha

; Geloneze, Bruno

; Ferreira, Sandra Roberta Gouvea

Archives of Endocrinology and Metabolism

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Fev 2023, Volume 67 Nº 1 Páginas 101 - 110

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: Intrauterine environment can induce fetal metabolic programming that predisposes to adiposity-related chronic diseases in its lifespan. We examined the associations of parental nutritional status and gestational weight gain with offspring body composition in early adulthood. Materials and methods: This is cross-sectional analysis of female participants of the NutriHS who were submitted to questionnaires, clinical examinations and body composition assessed by DXA. Association of pre-conception parental BMI and maternal gestational weight gain (exposures) with body composition measurements (outcomes) were analyzed using multiple linear models adjusted for Directed Acyclic Graphs-based covariables (maternal and paternal educational level, maternal age, and tobacco, alcohol and/or drugs use). The sample included 124 women (median 28 (24-31) years) with a mean BMI of 25.4 ± 4.7 kg/m2. Results: No association between previous paternal BMI and offspring’s body composition was detected. In the fully adjusted linear regression model, maternal BMI was associated with offspring’s total lean mass (β = 0.66, p = 0.001), appendicular skeletal muscle mass index (ASMI) (β = 0.11, p = 0.003) and fat mass index (FMI) (β = 0.03, p = 0.039). Gestational weight gain was associated with increased offspring’s BMI (OR 1.12 [95% CI 1.02-1.20], p = 0.01). The linear regression model adjusted for maternal age and maternal and paternal education levels showed associations of gestational weight gain with offspring’s ASMI (β = 0.42, p = 0.046), FMI (β = 0.22, p = 0.005) and android-to-gynoid fat ratio (β = 0.09, p = 0.035). Conclusion: Our findings suggest that preconception maternal BMI could influence lean mass and general adiposity of young adult female offspring and that gestational weight gain could be useful for predicting centrally distributed adiposity. Objective adiposityrelated related lifespan adulthood methods crosssectional cross sectional questionnaires DXA pre conception exposures (exposures outcomes (outcomes Graphsbased Graphs based level tobacco andor or use. use . use) 12 median 2 2431 24 31 (24-31 years 254 25 4 25. 47 7 4. kgm2 kgm kg m2 m kg/m2 Results offsprings s detected β 066 0 66 0.66 0.001, 0001 0.001 , 001 0.001) (ASMI 011 11 0.11 0.003 0003 003 (FMI 03 0.03 0.039. 0039 0.039 039 0.039) OR 112 1 1.1 95% 95 [95 1.021.20, 102120 1.02 1.20 02 20 1.02-1.20] 0.01. 0.01 01 0.01) 042 42 0.42 0.046, 0046 0.046 046 0.046) 022 22 0.22 0.005 0005 005 androidtogynoid android gynoid 009 09 0.09 0.035. 0035 0.035 035 0.035) Conclusion 243 3 (24-3 kg/m 06 6 0.6 000 0.00 00 0.1 0.0 1. 9 [9 021 1.021.20 10212 102 1.0 120 1.2 1.02-1.20 04 0.4 004 0.04 0.2 (24- 0. [ 1.021.2 1021 10 1.02-1.2 (24 1.021. 1.02-1. (2 1.021 1.02-1 ( 1.02-

https://doi.org/10.20945/2359-3997000000516

Use of prophylactic phototherapy for RhD neonatal disease in a referral service
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Rodrigues, Joyce Marques da Silva Robalinho

; Méio, Maria Dalva Barbosa Baker

; Santos, Maria Cristina Pessoa dos

; Costa, Ana Carolina Carioca da

; Moreira, Maria Elisabeth Lopes

Jornal de Pediatria

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Jan 2023, Volume 99 Nº 1 Páginas 53 - 58

Resumo: En | Texto: En | PDF: En

Abstract Objective: This study aimed to describe the effect of prophylactic phototherapy in the treatment of infants with Neonatal Hemolytic Disease. Method: A retrospective cohort study was carried out with 199 RhD-positive infants, born to RhD-negative mothers, alloimmunized for RhD antigen, between January 2009 and December 2018. Results: The incidence of exchange transfusions in the study population was 9.5%, with a mean maximum bilirubin value of 11.3 mg % (± 4.3mg %). Bilirubin’s maximum peak was achieved with a mean of 119.2 life hours (± 70.6h). Conclusions: The low incidence of exchange transfusion, the extended maximum bilirubin peak for later ages, and the low mean of the maximum bilirubin values may indicate a positive effect of prophylactic phototherapy in the treatment of this disease. Further studies must be carried out to confirm these findings. Objective Disease Method 19 RhDpositive RhDnegative negative mothers antigen 200 2018 Results 95 9 5 9.5% 113 11 3 11. ± ( 43mg 4 3mg %. . %) Bilirubins Bilirubin s 1192 119 2 119. 70.6h. 706h h 70.6h 70 6h 70.6h) Conclusions transfusion ages disease findings 1 20 201 9.5 7 9.

https://doi.org/10.1016/j.jped.2022.04.004

Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data
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Silva, Lunara Teles

; Modesto, Ana Carolina Figueiredo

; Oliveira, Rodrigo Alves de

; Amaral, Rita Goreti

; Lopes, Flavio Marques

Revista de Saúde Pública

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2022, Volume 56 elocation 86

Resumo: En | Texto: En | PDF: En

ABSTRACT OBJECTIVE To describe the frequency and characteristics of hospitalizations for/with adverse drug events in the Brazilian unified health system routine data. METHODS Nationwide retrospective study using data obtained from a period of ten years from the Brazil Hospital Information System (SIH-SUS), an administrative database that registers hospitalizations in the unified health system. We selected hospitalizations with primary and/or secondary diagnosis related to adverse drug events according to a list of validated International Classification Disease 10th edition (ICD-10) codes. These events were described according to year, age group, sex, length of hospital stay, mortality, hospital costs, Brazilian geographical region, and category of ICD-10 codes. Crude hospitalization rates of adverse drug events per 100,000 inhabitants were obtained and Joinpoint Regression was used to analyze temporal changes in these rates along the years. The most frequent ICD-10 codes were also identified. RESULTS Over ten years, 603,663 hospitalizations in Brazil were found in the database, out of which 2.5% of the patients died. Though 2009 had the highest prevalence of hospitalization per 100,000 inhabitants (32.57), no significant annual change in rates was found for the entire period. All age groups and sexes presented a jointpoint in temporal series; however, only women had a significative increase trend. The most frequent codes were from the chapter of mental and behavioral disorders (F19.2, F19.0, and F19.5 codes). CONCLUSIONS The database methodology can be useful to estimate frequencies of adverse drug events and perform characterization nationwide and to help monitor morbidity along the years.

https://doi.org/10.11606/s1518-8787.2022056003913

Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data
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Silva, Lunara Teles

; Modesto, Ana Carolina Figueiredo

; Oliveira, Rodrigo Alves de

; Amaral, Rita Goreti

; Lopes, Flavio Marques

Revista de Saúde Pública

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2022, Volume 56 elocation 86

Resumo: En | Texto: En | PDF: En

https://doi.org/10.11606/s1518-8787.2022056003913

10.

Effect of Titanium Hardness on the Integrity and Stress Concentration of External Hexagon Dental Implants
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Silva, Alecsandro de Moura

; Matos, Jefferson David Melo de

; Tribst, João Paulo Mendes

; da Rocha Scalzer Lopes, Guilherme

; da Silva Machado Martinelli, Carolina

; de Souto Borges, Alexandre Luiz

; Tomomitsu Kimpara, Estevão

; Nogueira-Junior, Lafayette

; Marques de-Melo, Renata

; Bottino, Marco Antonio

International journal of odontostomatology

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Dez 2021, Volume 15 Nº 4 Páginas 1053 - 1059

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT: The aim of this study was to evaluate the influence of overtorque on integrity, strength and stress on external hexagonal implants (EH), with two different grades (N=10): conventional (C), grade 4; and modified (M), grade 4 with thermal treatment. The dimensions of EH were 3.75 x 13 mm; the specimens were fixed and submitted to SEM analysis and image acquisition. The abutment was then retained with 70 N/cm, re-analyzed by SEM, and a second image was obtained. The images were analyzed by Image J software (1.44o- NIH, USA) for dimensional variations measurement on surface of the hexagonal area. The finite element method was applied with a similar compliance to calculate the resultant stress (MPa) during the torque. Results were statistically analyzed with t-student test (5 %). The dimensional accuracy of M (0.22 mm2) was statistically significant (p<0.05). Minimum principal stress and von-Mises stress of C (-19.95 MPa, -19.94 MPa), were lower than M values (-55.83 MPa, -55.96 MPa), respectively. However, the M group showed lower deformation than C group. Therefore, more rigid titanium alloy is a promising alternative to avoid plastic deformation of prosthetic connec tions even concentrating higher stress magnitude on its structure.

RESUMEN: El objetivo de este estudio fue evaluar la influencia del sobrepar en la integridad, la fuerza y la tensión en los implantes hexagonales externos (EH), con dos grados diferentes (N = 10): convencional (C), grado 4; y modificado (M), grado 4 con tratamiento térmico. Las dimensiones de EH eran 3,75 de diámetro x 13 mm de longitud; las muestras se fijaron y se sometieron a análisis SEM y adquisición de imágenes. A continuación, el pilar se retuvo con 70 N / cm, se volvió a analizar por SEM y se obtuvo una segunda imagen. Las imágenes se analizaron con el software Image J (1.44o-NIH, EE. UU.) Para medir las variaciones dimensionales en la superficie superior del área hexagonal, que fue causada por un par excesivo. El método de los elementos finitos se aplicó con un cumplimiento similar para calcular la tensión resultante (MPa) durante el par. Los resultados se analizaron estadísticamente con la prueba t-student (5 %). La precisión dimensional de M (0,22 mm2) fue estadísticamente significativa (p <0,05). La tensión principal mínima y la tensión de von-Mises de C (-19,95 MPa, -19,94 MPa), fueron inferiores a los valores de M (-55,83 MPa, -55,96 MPa), respectivamente. Sin embargo, el hexágono del grupo M mostró menor deformación que el grupo C. Por lo tanto, la aleación de titanio más rígida es una alternativa prometedora para evitar la deformación plástica de las conexiones protésicas incluso concentrando una mayor magnitud de tensión en su estructura.

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11.

Physical quality of eggs of four strains of poultry
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Almeida, Guilherme Resende de

; Mendonça, Michele de Oliveira

; Weitzel, Lidianne Carolina de Castro

; Bittencourt, Tatiana Marques

; Matos, Anderson Soares de

; Valentim, Jean Kaique

; Araújo, Michele Lopes de

; Oliveira, Adna Quesia Costa de

Acta Scientiarum. Animal Sciences

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2021, Volume 43 elocation e52738

Resumo: En | Texto: En | PDF: En

ABSTRACT. The layer poultry is an important activity for food production with high biological value. Measuring egg quality has great relevance to ensure safety and quality products for consumers. Thus, the objective was to evaluate the egg physical quality of four laying hen’s strains. Were used 864 eggs from four laying hens’ lines (Hisex Brown®, Hy-Line Brown®, Isa Label®, and Lohmann Brown®). The experimental design was completely randomized composed of four treatments (strains) with nine replications with four eggs each. Egg weight, egg diameter, egg length, specific gravity, yolk, albumen and shell weight and percentage, Haugh units, and shell thickness were evaluated. There was a significant difference for all parameters evaluated. The Hisex Brown® strain showed the best results for egg diameter, egg length, specific weight, albumen height, Haugh units, yolk weight, albumen%, shell weight, shell%, and shell thickness, while the Hy-Line Brown® produced bigger and heavier eggs, and Isa Label® presented the highest yolk%. The Hisex Brown® strain showed the better physical quality of eggs when compared to the other studied lines, the strain being indicated when the objective is to produce eggs with better internal and external quality.

https://doi.org/10.4025/actascianimsci.v43i1.52738

12.

COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves

; Ximenez, João Paulo Bianchi

; Seiva, Fábio Rodrigues Ferreira

; Panis, Carolina

; Bezerra, Rafael dos Santos

; Ferrasa, Adriano

; Cecchini, Alessandra Lourenço

; Medeiros, Alexandra Ivo de

; Almeida, Ana Marisa Fusco

; Ramão, Anelisa

; Boldt, Angelica Beate Winter

; Moya, Carla Fredrichsen

; Chin, Chung Man

; Paula, Daniel de

; Rech, Daniel

; Gradia, Daniela Fiori

; Malheiros, Danielle

; Venturini, Danielle

; Tavares, Eliandro Reis

; Carraro, Emerson

; Ribeiro, Enilze Maria de Souza Fonseca

; Pereira, Evani Marques

; Tuon, Felipe Francisco

; Follador, Franciele Aní Caovilla

; Fernandes, Glaura Scantamburlo Alves

; Volpato, Hélito

; Cólus, Ilce Mara de Syllos

; Oliveira, Jaqueline Carvalho de

; Rodrigues, Jean Henrique da Silva

; Santos, Jean Leandro dos

; Visentainer, Jeane Eliete Laguila

; Brandi, Juliana Cristina

; Serpeloni, Juliana Mara

; Bonini, Juliana Sartori

; Oliveira, Karen Brajão de

; Fiorentin, Karine

; Lucio, Léia Carolina

; Faccin-Galhardi, Ligia Carla

; Ferreto, Lirane Elize Defante

; Lioni, Lucy Megumi Yamauchi

; Consolaro, Marcia Edilaine Lopes

; Vicari, Marcelo Ricardo

; Arbex, Marcos Abdo

; Pileggi, Marcos

; Watanabe, Maria Angelica Ehara

; Costa, Maria Antônia Ramos

; Giannini, Maria José S. Mendes

; Amarante, Marla Karine

; Khalil, Najeh Maissar

; Lima Neto, Quirino Alves de

; Herai, Roberto H.

; Guembarovski, Roberta Losi

; Shinsato, Rogério N.

; Mainardes, Rubiana Mara

; Giuliatti, Silvana

; Yamada-Ogatta, Sueli Fumie

; Gerber, Viviane Knuppel de Quadros

; Pavanelli, Wander Rogério

; Silva, Weber Claudio da

; Petzl-Erler, Maria Luiza

; Valente, Valeria

; Soares, Christiane Pienna

; Cavalli, Luciane Regina

; Silva Jr, Wilson Araujo

Genetics and Molecular Biology

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2021, Volume 44 Nº 1 elocation e20200452

Resumo: En | Texto: En | PDF: En

Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.

https://doi.org/10.1590/1678-4685-gmb-2020-0452

13.

Characterization of adverse drug events identified by trigger in Brazilian pediatric inpatients
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Silva, Lunara Teles

; Modesto, Ana Carolina Figueiredo

; Martins, Renato Rocha

; Lopes, Flavio Marques

Jornal de Pediatria

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Jun 2020, Volume 96 Nº 3 Páginas 393 - 401

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Descrever a frequência e as características dos eventos adversos a medicamentos em pacientes pediátricos internados em um hospital universitário terciário brasileiro. Métodos: Foi realizado um estudo transversal por meio da análise retrospectiva e manual de prontuários de 240 internações pediátricas para identificar eventos adversos a medicamentos utilizando 17 rastreadores. Quando foram identificados rastreadores no prontuário, os analistas investigaram extensivamente o prontuário para decidir a respeito da existência de um evento. O consenso sobre a ocorrência do evento foi obtido em reunião com uma equipe de profissionais da saúde. Os eventos foram classificados por categoria de dano e os medicamentos foram classificados de acordo com a Classificação Anatômica Terapêutico-Química. Os pacientes que sofreram eventos adventos foram comparados aos que não apresentaram eventos adversos, com o teste qui-quadrado e o teste U de Mann-Whitney. Resultados: Verificou-se um total de 62 eventos adversos e 18,8% dos pacientes apresentaram ao menos evento. As taxas de eventos adversos foram de 25,83 por 100 internações, 20,27 por 1.000 pacientes/dia, 25,94 por 1.000 medicamentos e 2,12 por 1.000 doses de medicamentos. Todos os eventos encontrados foram classificados como dano temporário e os medicamentos cardiovasculares foram frequentemente associados aos eventos. Grupos de pacientes com e sem eventos apresentaram diferenças (p < 0,05) em relação ao tempo de internação, número e doses de medicamentos. Conclusão: O uso de rastreadores demonstrou sua utilidade no contexto pediátrico ao identificar danos. As taxas de eventos adversos foram maiores do que as taxas de estudos anteriores, porém a categoria de dano foi menor que em outros estudos. Este estudo possibilita a medição dos eventos adversos a fim de definir estratégias para minimizar ou reduzir os danos.

Abstract Objective: To describe the frequency and characteristics of adverse drug events in pediatric inpatients in a Brazilian tertiary teaching hospital. Methods: A cross-sectional study was conducted by retrospective and manual chart review of 240 pediatric admissions to identify adverse drug events using 17 triggers. When triggers were detected in the chart, reviewers investigated the chart in depth to decide whether an event occurred. Consensus about the occurrence of the event was obtained in meeting with a healthcare team. Events were classified by harm category and drugs were classified according to the Anatomical Therapeutic Chemical Classification. Patients who had suffered were compared to those who had not experienced events using the chi-squared test and the Mann-Whitney U test. Results: A total of 62 adverse events were found, and 18.8% of the patients had at least one event. Adverse events rates were 25.83 per 100 admissions, 20.27 per 1000 patient-days, 25.94 per 1000 drugs, and 2.12 per 1000 drug doses. All events found were classified as temporary harm, and cardiovascular drugs were most frequently related to events. Groups of patients with and without event were segregated (p < 0.05) by the length of stay, number of drugs, and drug doses. Conclusion: The use of triggers demonstrated its utility in a pediatric setting by identifying harm. Adverse events rates were found to be higher than those of previous studies, but the harm rate was lower than other studies. This study enables the measurement of adverse events in order to define strategies to mitigate or reduce harm.

https://doi.org/10.1016/j.jped.2018.12.009 661 downloads

14.

The Brazilian Portuguese version of the Pediatric Trigger Toolkit is applicable to measure the occurrence of adverse drug events in Brazilian pediatric inpatients
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Silva, Lunara Teles

; Modesto, Ana Carolina Figueiredo

; Martins, Renato Rocha

; Bessa, Gabriela Guimarães

; Lopes, Flavio Marques

Jornal de Pediatria

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Fev 2019, Volume 95 Nº 1 Páginas 61 - 68

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo: Descrever o processo de tradução, adaptação e validação para o português do Pediatric Trigger Toolkit: Measuring Adverse Drug Events in the Children's Hospital. Métodos: O processo de validação do instrumento de pesquisa foi realizado em 5 etapas: (I) tradução do inglês para o português por dois tradutores independentes; (II) síntese das versões traduzidas; (III) adaptação dos rastreadores para realidade brasileira por meio do método Delphi modificado, em duas rodadas; (IV) aplicação do instrumento de pesquisa na revisão de 240 internações de 2014; e (V) retrotradução do português para o inglês. Resultados: A etapa de tradução resultou em duas versões traduzidas, que foram sintetizadas de forma a obter equivalência ao contexto cultural brasileiro. O processo de adaptação do instrumento de pesquisa possibilitou a inclusão e adaptação dos rastreadores, bem como a exclusão de rastreadores segundo consenso obtido entre os especialistas na etapa Delphi. O valor preditivo positivo do instrumento de pesquisa foi de 13,51% e o rastreador anti-histamínico foi o que apresentou maior valor preditivo positivo. Conclusão: O instrumento de pesquisa pode ser utilizado para rastrear a ocorrência de eventos adversos a medicamentos em pacientes pediátricos nos hospitais brasileiros. Apesar das adaptações realizadas, rastreadores que não foram identificados ou com baixo valor preditivo positivo podem indicar, ainda, a necessidade de modificações. Entretanto, mais estudos são necessários antes de modificar ou excluir algum rastreador.

Abstract Objective: To describe the process of translation, adaptation, and validation of the Brazilian Portuguese version of the Pediatric Trigger Toolkit: Measuring Adverse Drug Events in the Children's Hospital. Methods: The validation process for the research instrument was carried out in five steps: (I) translation from English into Brazilian Portuguese by two independent translators; (II) synthesis of the translated versions; (III) adaptation of the triggers to the Brazilian context using a modified Delphi method carried out in two rounds; (IV) application of the research instrument in the review of 240 hospitalizations during 2014; and (V) back-translation from Brazilian Portuguese to English. Results: The translation step resulted in two versions, which were then synthesized to obtain equivalence within the Brazilian cultural context. The process of adapting the research instrument allowed the inclusion and adaptation of some triggers, as well as the exclusion of others, based on the consensus reached among experts during the Delphi step. The positive predictive value of the research instrument was 13.51%, and the antihistamine trigger presented the highest positive predictive value. Conclusion: The research instrument can be used to track the occurrence of adverse drug events in pediatric patients in Brazilian hospitals. Despite the adjustments made, triggers that were not identified or that had low positive predictive value can suggest the need for additional changes. However, more studies are needed before modifying or removing a trigger.

https://doi.org/10.1016/j.jped.2017.10.009 1178 downloads

15.

What do Cochrane systematic reviews say about new practices on integrative medicine?
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Riera, Rachel

; Braga, Vinícius Lopes

; Rocha, Luana Pompeu dos Santos

; Bernardo, Daniel Damasceno

; Andrade, Luísa Avelar Fernandes de

; Hsu, Jessica Chiu

; Silva, Luciana Di Giovanni Marques da

; Suetsugu, Rodrigo Cesar de Sá

; Dittrich, Nicole Hosni

; Lima, Lucas Riguete Pereira de

; Silveira, Vicente Penido da

; Kruglensky, Barbara Caon

; Leonel, Letícia de Freitas

; Barros, Edivando de Moura

; Costa, Anderson Adriano Leal Freitas da

; Quintella, Miguel Lins

; Pacheco, Rafael Leite

; Cruz, Carolina de Oliveira

; Martimbianco, Ana Luiza Cabrera

; Pachito, Daniela Vianna

; Mozetic, Vania

; Teixeira, Tatiana de Bruyn Ferraz

; Torloni, Maria Regina

; Atallah, Alvaro Nagib

Sao Paulo Medical Journal

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Mai 2018, Volume 136 Nº 3 Páginas 251 - 261

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: This study identified and summarized all Cochrane systematic reviews (SRs) on the effects of ten integrative practices that were recently added to the Brazilian public healthcare system (SUS). DESIGN AND SETTING: Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp). METHODS: Review of Cochrane SRs on the following interventions were identified, summarized and critically assessed: apitherapy, aromatherapy, bioenergetics, family constellation, flower therapy, chromotherapy, geotherapy, hypnotherapy, hand imposition or ozone therapy. RESULTS: We included a total of 16 SRs: 4 on apitherapy, 4 on aromatherapy, 6 on hypnotherapy and 2 on ozone therapy. No Cochrane SR was found regarding bioenergetics, family constellation, chromotherapy, clay therapy, flower therapy or hand imposition. The only high-quality evidence was in relation to the potential benefit of apitherapy, specifically regarding some benefits from honey dressings for partial healing of burn wounds, for reduction of coughing among children with acute coughs and for preventing allergic reactions to insect stings. CONCLUSION: Except for some specific uses of apitherapy (honey for burn wounds and for acute coughs and bee venom for allergic reactions to insect stings), the use of ten integrative practices that have recently been incorporated into SUS does not seem to be supported by evidence from Cochrane SRs.

https://doi.org/10.1590/1516-3180.2018.0172170418 2326 downloads

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