Abstract This study evaluated the orofacial antinociceptive effect of (S)-(-)-perillyl alcohol (PA) associated with codeine (C) and investigated the possible molecular anchorage mechanisms of PA. Mice (n = 5 per group) were treated with PA alone and associated with codeine and assigned to the following groups: 75.0 mg/kg PA; 75.0 mg/kg PA + C 30 mg/kg; PA 37.5 mg/kg + C 15.0 mg/kg; C 30.0 mg/kg; and control. Nociception was induced by formalin, capsaicin, and glutamate, and was quantified based on the duration (in seconds) of face grooming. The possible mechanisms of action were evaluated by molecular docking study. In the formalin test, PA75/C30 presented an effect in the neurogenic (p < 0.0001) and inflammatory (p < 0.005) phases. Mice treated with PA75 (p < 0.0001) and PA75/C30 (p < 0.0005) showed a reduced nociceptive behavior in the capsaicin test. Glutamate-induced nociception also was blocked by PA75 (p < 0.0005) and C30 (p < 0.0005). The molecular anchorage analysis indicated high negative binding energy values for the evaluated receptors, especially glutamate receptors (AMPA -79.57 Kcal/mol, mGLUR6 -71.25, and NMDA -66.33 Kcal/mol). PA associated with codeine showed orofacial antinociceptive activity, with theoretical evidence of interaction with glutamate receptors.

Abstract Objective: This study sought to identify the differences between the oral changes presented by patients with solid and hematologic tumors during chemotherapeutic treatment. Methodology: This is an observational, prospective and quantitative study using direct documentation by follow-up of 105 patients from 0 to 18 years using the modified Oral Assessment Guide (OAG). Of the 105 patients analyzed, 57 (54.3%) were boys with 7.3 years (±5.2) mean age. Hematologic neoplasms accounted for 51.4% of all cases. Results: Voice, lips, tongue, and saliva changes were not significantly different (p>0.05) between patients with solid or hematologic tumors and during the follow-up. From the 6th until the 10th week of chemotherapeutic treatment alterations in swallowing function, in the mucous membrane (buccal mucosa and palate), in the labial mucosa, and in the gingiva occurred and were distributed differently between the two tumors groups (p<0.05). The main alterations were observed in patients with hematologic tumors. Conclusion: It was concluded that the oral changes during the chemotherapeutic treatment occurred especially in swallowing function, in the mucous membrane, in the labial mucosa and in the gingiva, and these alterations were found mainly in patients with hematologic tumors.

RESUMO Objetivo: verificar o perfil dos usuários com queixas fonoaudiológicas do serviço de atenção domiciliar do município de João Pessoa, Paraíba. Métodos: trata-se de um estudo transversal, descritivo, natureza quantitativa, mediante técnica de documentação indireta a partir da análise de documentos de fontes primárias, sendo caracterizado, portanto, como estudo documental. A pesquisa foi realizada junto ao serviço de atenção domiciliar (SAD) do município de João Pessoa/PB, que dispõe de informações dos usuários armazenadas em forma de prontuários. Todos os prontuários dos pacientes atendidos pelo SAD no período de junho de 2012 a junho de 2016 foram analisados, e após os critérios de elegibilidade, amostra ficou constituída por 114 prontuários. Os dados coletados foram inseridos em uma planilha do Microsoft Excel para realização de estatística descritiva no Software IBM SPSS (versão 21.0). Resultados: verificou-se que a maioria dos pacientes atendidos foi do sexo masculino (59,6%), idosos (62,3%) e diagnosticados com acidente vascular encefálico (57,9%). Além disso, apresentaram histórico de disfagia (76,3%), problemas de fala (58,8%), deglutição alterada (80,7%) e mastigação alterada (77,2%). A disfagia está frequentemente associada aos AVE’s apresentando predomínio de indivíduos do sexo masculino e idosos. Conclusão: concluiu-se que a alteração de dificuldade de deglutição, ou seja, a disfagia está frequentemente associada aos AVE’s apresentando o predomínio das variáveis sociodemográficas e clínicas de homens e idosos.

ABSTRACT Objective: to ascertain the profile of home care service (HCS) users with speech and language complaints in João Pessoa, Paraíba (PB). Methods: a descriptive and quantitative study using an indirect documentation technique based on an analysis of primary source documents, characterized as a documentary study, conducted at a HCS, in João Pessoa, PB, that stores user information in the form of medical records. All patient records included by the HCS from June 2012 to June 2016 were analyzed. After the eligibility criteria were applied, the sample consisted of 114 medical records. The collected data were entered into a Microsoft Excel spreadsheet to generate descriptive statistics using IBM SPSS (version 21.0). Results: most patients were males (59.6%), elderly (62.3%), had been diagnosed with a stroke (57.9%),had histories of dysphagia (76.3%), speech problems (58.8%), swallowing disorders (80.7%), and abnormal chewing (77.2%). Dysphagia is often associated with stroke, predominantly among males and the elderly. Conclusion difficulty in swallowing, or dysphagia, is often associated with stroke, predominantly in the presence of the sociodemographic and clinical variables associated with men and the elderly.

RESUMO Objetivo: objetivou-se avaliar a qualidade metodológica dos ensaios clínicos publicados em periódicos brasileiros. Métodos: trata-se de uma pesquisa bibliográfica sistemática. Participaram quatro pesquisadores independentes treinados que realizaram um levantamento dos últimos 10 anos em todos os periódicos nacionais da área da Fonoaudiologia, ativos ou inativos. Para tanto, foram selecionados todos os volumes desse período de tempo e cada pesquisador realizou análise individual a fim de identificar estudos que tinham o principal objeto de estudo enquadrado na Motricidade Orofacial. Foram utilizados os seguintes instrumentos Downs and Black Quality Checklist e escala de Jadad. Resultados: após a seleção e categorização dos estudos, a amostra final desta pesquisa foi composta por 6 artigos classificados como ensaios clínicos. Dentre as limitações metodológicas observadas destacam-se a ausência de plano amostral, randomização e cegamento. Identificou-se uma média de 16,3 pontos para o Downs and Black Quality Checklist e 2,3 para escala de Jadad. Conclusão: conclui-se que a literatura brasileira é escassa de ensaios clínicos controlados randomizados na área de motricidade orofacial, sugerindo ampliação e qualificação das investigações que adotam esse delineamento de pesquisa, promovendo, dessa forma, uma prática clínica baseada em evidência científica.

ABSTRACT Purpose: to evaluate the methodological quality of clinical trials published in Brazilian journals. Methods: four trained independent researchers conducted a systematic literature search of all Brazilian speech therapy-related journals over the last ten years, whether the journals were active or inactive. All journal volumes published during that period were selected, and each researcher conducted an individual analysis to identify articles that focused primarily on orofacial motricity. The tools used were the Downs and Black Quality Checklist and the Jadad scale. Results: after the studies were selected and categorized, the final sample comprised six articles, all of which were classified as clinical trials. The observed methodological limitations included a lack of sample planning, randomization and blinding. Mean scores of 16.3 points on the Downs and Black Quality Checklist and 2.3 on the Jadad scale were obtained. Conclusion: the randomized controlled trials in the area of orofacial motricity are scarce in Brazilian literature, suggesting that studies in this area adopting this research design should be expanded and their quality should be improved to promote clinical practice based on scientific evidence.

RESUMO Esta pesquisa revisou de modo integral a produção científica brasileira em Motricidade Orofacial nos últimos 10 anos e teve como objetivo realizar uma descrição e categorização geral das publicações em motricidade orofacial e analisar os estudos quantitativos na área. Os dados foram coletados em todas as publicações em motricidade orofacial publicadas nos últimos dez anos, após uma análise integral de todos os periódicos brasileiros em Fonoaudiologia. Os artigos foram categorizados quanto ao ano, tipo de artigo e área temática. Além disso, foram analisados sobre a faixa etária, abrangência, essência do objetivo e tipo de estudo todos os artigos realizados com seres humanos e com dados quantitativos. Os dados foram discutidos sob a ótica da metodologia científica aplicada ao aperfeiçoamento do método e desenvolvimento da ciência baseado em evidências. Além disto, os dados são analisados com sugestões de aspectos potenciais a serem considerados para futuras pesquisas na área.

ABSTRACT A complete review of Brazilian scientific articles on orofacial myology (OM) published in the last 10 years was conducted to describe, categorize and quantitatively analyze studies in the field of OM. Data were collected from all Brazilian journals on speech-language and hearing sciences published between 2005 and 2015. All articles were reviewed and categorized according to the year of publication, type of article and subject area. Furthermore, all studies conducted on humans that reported quantitative data were analyzed regarding age group, scope, main objective and type of study. The data were discussed from the standpoint of scientific methodology applied for the improvement of methods and for evidence-based scientific development. Moreover, aspects to be considered in future studies in this field are suggested.