SUMMARY OBJECTIVE: This study examines the relationship between two frailty screening tools and 90-day all-cause mortality in geriatric inpatients. METHODS: The study included patients aged ≥60 years who were admitted to the geriatrics unit of a university hospital between June 2021 and August 2022 and whose mortality status and duration of hospitalization data were obtained from the Health Ministry System. During hospitalization, the patients were screened using two different frailty scales: the Simpler Modified Fried Frailty Scale (sMFS) and the Clinical Frailty Scale (CFS). Patients scoring ≥5 on the CFS and ≥3 on the sMFS were considered frail. RESULTS: A total of 84 participants with a mean age of 78.3±7.6 years were included in this study, of which 36.9% were male. Of the total, 60.7% and 89.3% were considered frail according to the CFS and sMFS, respectively, and the prevalence of all-cause mortality within 90 days was 19%. A univariate analysis using the Kaplan-Meier survival method revealed CFS scores to be statistically significantly related to 90-day all-cause mortality (p<0.001), while sMFS scores were not found to be statistically significant (p=0.849). Furthermore, a statistically significant relationship was identified between CFS score and all-cause mortality in multivariate analysis with Cox regression analysis [(p<0.001), hazard ratio (HR): 3.078; (95% confidence interval: 1.746-5.425)]. CONCLUSION: An evaluation of frailty in hospitalized older adults using two different scales revealed the CFS to be superior to the sMFS in predicting all-cause mortality within 90 days. OBJECTIVE 90day day allcause all cause inpatients METHODS 60 ≥6 202 System (sMFS CFS. . (CFS) 5 ≥ 3 RESULTS 8 78376 78 7 6 78.3±7. 369 36 9 36.9 male 607 60.7 893 89 89.3 respectively 19 19% KaplanMeier Kaplan Meier p<0.001, p0001 p p<0.001 , 0 001 (p<0.001) p=0.849. p0849 p=0.849 849 (p=0.849) Furthermore [(p<0.001) HR (HR) 3.078 3078 078 95% 95 (95 interval 1.7465.425. 17465425 1.746 5.425 1 746 425 1.746-5.425)] CONCLUSION 20 (CFS 7837 78.3±7 36. 60. 89. p000 p<0.00 00 (p<0.001 p084 p=0.84 (p=0.849 [(p<0.001 (HR 3.07 307 07 (9 7465 1.7465.425 1746542 1746 1.74 5425 5.42 74 42 1.746-5.425) 2 783 78.3± p00 p<0.0 (p<0.00 p08 p=0.8 (p=0.84 [(p<0.00 3.0 30 ( 1.7465.42 174654 174 1.7 542 5.4 4 1.746-5.425 78.3 p0 p<0. (p<0.0 p=0. (p=0.8 [(p<0.0 3. 1.7465.4 17465 17 1. 54 5. 1.746-5.42 78. p<0 (p<0. p=0 (p=0. [(p<0. 1.7465. 1.746-5.4 p< (p<0 p= (p=0 [(p<0 1.7465 1.746-5. (p< (p= [(p< 1.746-5 (p [(p 1.746-

SUMMARY OBJECTIVE: While the literature contains several studies on the frailty assessed during hospitalization and/or outpatient settings and nursing homes, few studies have assessed frailty in community-dwelling older adults. We investigated the prevalence of frailty and associated factors among older adults in a sample of community-dwelling older adults. METHODS: We included community-dwelling older adults >60 years living in the Fatih District of the Istanbul Province. We conducted the study between November 2014 and May 2015. We collected the data such as age, sex, number of diseases and drugs, functional status, frailty, the presence of geriatric syndromes, common diseases, and quality-of-life assessment. Frailty was evaluated by the FRAIL scale. RESULTS: A total of 204 adults (mean age: 75.4±7.3 years) were included, of whom 30.4% were robust, 42.6% were pre-frail, and 27% were frail. In multivariate analyses, associated factors of frailty were the number of drugs [odds ratio (OR)=1.240, p=0.036], the presence of cognitive impairment (OR=0.300, p=0.016), and falls (OR=1.984, p=0.048). CONCLUSION: The present study established the prevalence of frailty in a large district in the largest metropolis in the country through a valid screening method. Our results suggest that clinicians should consider frailty evaluation in patients with multiple drug usage, cognitive impairment, and falls. OBJECTIVE andor or homes communitydwelling community dwelling METHODS 60 >6 Province 201 2015 age sex status syndromes qualityoflife quality life assessment scale RESULTS 20 mean 75473 75 4 7 3 75.4±7. 304 30 30.4 robust 426 42 6 42.6 prefrail, prefrail pre frail, frail pre-frail 27 analyses odds OR=1.240, OR1240 OR =1.240, 1 240 (OR)=1.240 p=0.036, p0036 p p=0.036 , 0 036 p=0.036] OR=0.300, OR0300 300 (OR=0.300 p=0.016, p0016 p=0.016 016 p=0.016) OR=1.984, OR1984 984 (OR=1.984 p=0.048. p0048 p=0.048 . 048 p=0.048) CONCLUSION method usage > 2 7547 75.4±7 30. 42. OR=1.240 OR124 1240 =1.240 24 (OR)=1.24 p003 p=0.03 03 OR=0.300 OR030 (OR=0.30 p001 p=0.01 01 OR=1.984 OR198 98 (OR=1.98 p004 p=0.04 04 754 75.4± OR=1.24 OR12 124 =1.24 (OR)=1.2 p00 p=0.0 OR=0.30 OR03 (OR=0.3 OR=1.98 OR19 9 (OR=1.9 75.4 OR=1.2 OR1 12 =1.2 (OR)=1. p0 p=0. OR=0.3 OR0 (OR=0. OR=1.9 (OR=1. 75. OR=1. =1. (OR)=1 p=0 OR=0. (OR=0 (OR=1 OR=1 =1 (OR)= p= OR=0 (OR= OR= = (OR) (OR

Abstract: We studied dynamic thiol/disulphide homeostasis, an indicator of oxidative stress, to investigate the effects of newly initiated exercise training on sedentary obese adults. Seventeen sedentary obese adults and 15 normal-weight controls were included in the sample for this study. The obese adults were given a physical exercise training program that lasted twelve weeks. Before and after the exercise training program, blood samples were collected, and serum thiol/disulphide parameters were measured by using a novel technique. Before the start of the exercise training, it was observed that thiol/disulphide homeostasis was impaired, and this impairment was positively correlated with body mass index in sedentary obese adults because of the higher reactive oxygen species production in adipose tissue. However, while the obese participants’ body mass index significantly decreased, the thiol/disulphide homeostasis parameters in the obese adults did not change over time as calculated at the baseline and compared to the calculation after the twelve weeks of exercise training. Despite a decrease in body mass index that occurred after the twelve weeks of exercise training, there was a lack of improvement in the obesity-induced impairment of thiol/disulphide homeostasis, which suggests that a newly initiated exercise training program may lead to oxidative stress.