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Abstract Background Sjogren-Larsson syndrome (SLS) is a neurocutaneous disease with an autosomal recessive inheritance, caused by mutations in the gene that encodes fatty aldehyde dehydrogenase (ALDH3A2), clinically characterized by ichthyosis, spastic diplegia, and cognitive impairment. Brain imaging plays an essential role in the diagnosis, demonstrating a nonspecific leukoencephalopathy. Data regarding brain atrophy and grey matter involvement is scarce and discordant. Objective We performed a volumetric analysis of the brain of two siblings with SLS with the aim of detecting deep grey matter nuclei, cerebellar grey matter, and brainstem volume reduction in these patients. Methods Volume data obtained from the brain magnetic resonance imaging (MRI) of the two patients using an automated segmentation software (Freesurfer) was compared with the volumes of a healthy control group. Results Statistically significant volume reduction was found in the cerebellum cortex, the brainstem, the thalamus, and the pallidum nuclei. Conclusion Volume reduction in grey matter leads to the hypothesis that SLS is not a pure leukoencephalopathy. Grey matter structures affected in the present study suggest a dysfunction more prominent in the thalamic motor pathways. SjogrenLarsson Sjogren Larsson (SLS inheritance ALDH3A2, ALDH3A2 ALDHA , ALDH A (ALDH3A2) ichthyosis diplegia impairment diagnosis leukoencephalopathy discordant nuclei MRI (MRI Freesurfer (Freesurfer group cortex thalamus pathways ALDH3A (ALDH3A2 (ALDH3A

Resumo Antecedentes A Síndrome de Sjogren-Larsson (SSL) é uma doença neurocutânea de herança autossômica recessiva, causada por mutações no gene que codifica a aldeído graxo desidrogenase (ALDH3A2), caracterizada clinicamente por ictiose, diplegia espástica e comprometimento cognitivo. A imagiologia cerebral desempenha um papel essencial no diagnóstico, demonstrando uma leucoencefalopatia inespecífica. Dados sobre atrofia cerebral e envolvimento da substância cinzenta são escassos e discordantes. Objetivo Realizamos uma análise volumétrica do cérebro de dois irmãos com SLS com o objetivo de detectar núcleos profundos de substância cinzenta, substância cerebral cinzenta e redução do volume do tronco encefálico nestes pacientes. Métodos Os dados de volume obtidos da ressonância magnética (RM) cerebral dos dois pacientes usando um software de segmentação automática (Freesurfer) foram comparados com os volumes de um grupo controle saudável. Resultados Redução de volume estatisticamente significativa foi encontrada no córtex do cerebelo, no tronco cerebral, no tálamo e nos núcleos pálidos. Conclusão A redução do volume da substância cinzenta leva à hipótese de que a SSL não é uma leucoencefalopatia pura. As estruturas da substância cinzenta afetadas no presente estudo sugerem uma disfunção mais proeminente nas vias motoras talâmicas. SjogrenLarsson Sjogren Larsson (SSL recessiva ALDH3A2, ALDH3A2 ALDHA , ALDH (ALDH3A2) ictiose cognitivo diagnóstico inespecífica discordantes RM (RM Freesurfer (Freesurfer saudável cerebelo pálidos pura talâmicas ALDH3A (ALDH3A2 (ALDH3A

https://doi.org/10.1055/s-0043-1772601

COVID-19 outcomes in people living with HIV: Peering through the waves COVID19 COVID 19 COVID-1 HIV COVID1 1 COVID-
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Sales, Thaís Lorenna Souza

; Souza-Silva, Maíra Viana Rego

; Delfino-Pereira, Polianna

; Neves, João Victor Baroni

; Sacioto, Manuela Furtado

; Assis, Vivian Costa Morais de

; Duani, Helena

; Oliveira, Neimy Ramos de

; Sampaio, Natália da Cunha Severino

; Ramos, Lucas Emanuel Ferreira

; Schwarzbold, Alexandre Vargas

; Jorge, Alzira de Oliveira

; Scotton, Ana Luiza Bahia Alves

; Castro, Bruno Mateus de

; Silva, Carla Thais Cândida Alves da

; Ramos, Carolina Marques

; Anschau, Fernando

; Botoni, Fernando Antonio

; Grizende, Genna Maira Santos

; Nascimento, Guilherme Fagundes

; Ruschel, Karen Brasil

; Menezes, Luanna Silva Monteiro

; Castro, Luís César de

; Nasi, Luiz Antônio

; Carneiro, Marcelo

; Godoy, Mariana Frizzo de

; Nogueira, Matheus Carvalho Alves

; Guimarães Júnior, Milton Henriques

; Ziegelmann, Patricia Klarmann

; Almeida, Rafaela Charão de

; Francisco, Saionara Cristina

; Silveira Neto, Sidney Teodoro

; Araújo, Silvia Ferreira

; Avelino-Silva, Thiago Junqueira

; Aliberti, Márlon Juliano Romero

; Pires, Magda Carvalho

; Silva, Eduardo Sérgio da

; Marcolino, Milena Soriano

Clinics

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2023, Volume 78 elocation 100223

Resumo: En | Texto: En | PDF: En

Abstract Objective To evaluate clinical characteristics and outcomes of COVID-19 patients infected with HIV, and to compare with a paired sample without HIV infection. Methods This is a substudy of a Brazilian multicentric cohort that comprised two periods (2020 and 2021). Data was obtained through the retrospective review of medical records. Primary outcomes were admission to the intensive care unit, invasive mechanical ventilation, and death. Patients with HIV and controls were matched for age, sex, number of comorbidities, and hospital of origin using the technique of propensity score matching (up to 4:1). They were compared using the Chi-Square or Fisher's Exact tests for categorical variables and the Wilcoxon for numerical variables. Results Throughout the study, 17,101 COVID-19 patients were hospitalized, and 130 (0.76%) of those were infected with HIV. The median age was 54 (IQR: 43.0;64.0) years in 2020 and 53 (IQR: 46.0;63.5) years in 2021, with a predominance of females in both periods. People Living with HIV (PLHIV) and their controls showed similar prevalence for admission to the ICU and invasive mechanical ventilation requirement in the two periods, with no significant differences. In 2020, in-hospital mortality was higher in the PLHIV compared to the controls (27.9% vs. 17.7%; p = 0.049), but there was no difference in mortality between groups in 2021 (25.0% vs. 25.1%; p > 0.999). Conclusions Our results reiterate that PLHIV were at higher risk of COVID-19 mortality in the early stages of the pandemic, however, this finding did not sustain in 2021, when the mortality rate is similar to the control group. COVID19 COVID 19 COVID-1 infection (202 2021. . 2021) records unit death sex comorbidities up 41. 41 4 1 4:1) ChiSquare Chi Square Fishers Fisher s study 17101 17 101 17,10 hospitalized 13 0.76% 076 0 76 (0.76% 5 IQR (IQR 43.064.0 430640 43.0 64.0 43 64 43.0;64.0 202 46.063.5 460635 46.0 63.5 46 63 46.0;63.5 (PLHIV differences inhospital 27.9% 279 27 9 (27.9 vs 17.7% 177 7 0.049, 0049 0.049 , 049 0.049) 25.0% 250 25 (25.0 25.1% 251 0.999. 0999 0.999 999 0.999) pandemic however group COVID1 COVID- (20 4:1 1710 10 17,1 0.76 07 (0.76 064 43.064. 43064 430 43. 640 64. 6 43.0;64. 20 063 46.063. 46063 460 46. 635 63. 46.0;63. 27.9 2 (27. 17.7 004 0.04 04 25.0 (25. 25.1 099 0.99 99 (2 4: 171 17, 0.7 (0.7 06 43.064 4306 43.0;64 46.063 4606 46.0;63 27. (27 17. 00 0.0 25. (25 09 0.9 ( 0. (0. 43.06 43.0;6 46.06 46.0;6 (0 43.0; 46.0;

https://doi.org/10.1016/j.clinsp.2023.100223

Transforming the invisible into the visible: disparities in the access to health in LGBT+ older people visible LGBT
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Crenitte, Milton Roberto Furst

; Melo, Leonardo Rabelo de

; Jacob Filho, Wilson

; Avelino-Silva, Thiago Junqueira

Clinics

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2023, Volume 78 elocation 100149

Resumo: En | Texto: En | PDF: En

Abstract Objectives: To compare variables of access to healthcare between the LGBT+ population aged 50 and over and those non-LGBT+. Methods: A cross-sectional study was carried out in Brazil through a confidential online questionnaire. The use of the health system was characterized by the number of preventive tests performed and measured by the PCATool-Brasil scale (a 10-point scale in which higher scores were associated with better assistance in healthcare). The association between being LGBT+ and access to health was analyzed in Poisson regression models. Results: 6693 participants (1332 LGBT+ and 5361 non-LGBT+) with a median age of 60 years were included. In the univariate analysis, it was observed not only lower scores on the PCATool scale (5.13 against 5.82, p < 0.001), but a greater proportion of individuals among those classified with the worst quintile of access to healthcare (< 4 points), 31% against 18% (p < 0.001). Being LGBT+ was an independent factor associated with worse access to health (PR = 2.5, 95% CI 2.04‒3.06). The rate of screening cancer, for breast, colon, and cervical cancer was also found to be lower in the LGBT+ population. Conclusion: Healthcare access and health service experiences were worse in the LGBT+ group than in their non-LGBT peers. Inclusive and effective healthcare public policies are essential to promote healthy aging for all. Objectives LGBT 5 nonLGBT+. nonLGBT non LGBT+. non-LGBT+ Methods crosssectional cross sectional questionnaire PCAToolBrasil Brasil 10point point 10 healthcare. . healthcare) models Results 669 1332 (133 536 nonLGBT+ 6 included analysis 5.13 513 13 (5.1 582 82 5.82 0.001, 0001 0.001 , 0 001 0.001) ( points, points points) 31 18 0.001. PR 25 2 2.5 95 2.04‒3.06. 204306 2.04‒3.06 04 3 06 2.04‒3.06) breast colon Conclusion peers all 1 66 133 (13 53 5.1 51 (5. 58 8 5.8 000 0.00 00 2. 9 20430 2.04‒3.0 (1 5. (5 0.0 2043 2.04‒3. 0. 204 2.04‒3 20 2.04‒ 2.04 2.0

https://doi.org/10.1016/j.clinsp.2022.100149

Recommendations by the Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and the Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) on vaccination in general and specifically against SARS-CoV-2 for patients with demyelinating diseases of the central nervous system
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Becker, Jefferson

; Ferreira, Lis Campos

; Damasceno, Alfredo

; Bichuetti, Denis Bernardi

; Christo, Paulo Pereira

; Callegaro, Dagoberto

; Peixoto, Marco Aurélio Lana

; Sousa, Nise Alessandra De Carvalho

; Almeida, Sérgio Monteiro De

; Adoni, Tarso

; Santiago-Amaral, Juliana

; Junqueira, Thiago

; Pereira, Samira Luisa Apóstolos

; Gomes, Ana Beatriz Ayroza Galvão Ribeiro

; Pitombeira, Milena

; Paolilo, Renata Barbosa

; Grzesiuk, Anderson Kuntz

; Piccolo, Ana Claudia

; D´Almeida, José Arthur Costa

; Gomes Neto, Antonio Pereira

; Oliveira, Augusto Cesar Penalva De

; Oliveira, Bianca Santos De

; Tauil, Carlos Bernardo

; Vasconcelos, Claudia Ferreira

; Kaimen-Maciel, Damacio

; Varela, Daniel

; Diniz, Denise Sisterolli

; Oliveira, Enedina Maria Lobato De

; Malfetano, Fabiola Rachid

; Borges, Fernando Elias

; Figueira, Fernando Faria Andrade

; Gondim, Francisco De Assis Aquino

; Passos, Giordani Rodrigues Dos

; Silva, Guilherme Diogo

; Olival, Guilherme Sciascia Do

; Santos, Gutemberg Augusto Cruz Dos

; Ruocco, Heloisa Helena

; Sato, Henry Koiti

; Soares Neto, Herval Ribeiro

; Cortoni Calia, Leandro

; Gonçalves, Marcus Vinícius Magno

; Vecino, Maria Cecilia Aragón De

; Pimentel, Maria Lucia Vellutini

; Ribeiro, Marlise De Castro

; Boaventura, Mateus

; Parolin, Mônica Koncke Fiuza

; Melo, Renata Brant De Souza

; Lázaro, Robson

; Thomaz, Rodrigo Barbosa

; Kleinpaul, Rodrigo

; Dias, Ronaldo Maciel

; Gomes, Sidney

; Lucatto, Simone Abrante

; Alves-Leon, Soniza Vieira

; Fukuda, Thiago

; Ribeiro, Taysa Alexandrino Gonsalves Jubé

; Winckler, Thereza Cristina D’ávila

; Fragoso, Yara Dadalti

; Nascimento, Osvaldo José Moreira Do

; Ferreira, Maria Lucia Brito

; Mendes, Maria Fernanda

; Brum, Doralina Guimarães

; Glehn, Felipe Von

Arquivos de Neuro-Psiquiatria

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Nov 2021, Volume 79 Nº 11 Páginas 1049 - 1061

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O DC de Neuroimunologia da ABN e o BCTRIMS trazem, nesse documento, as recomendações sobre vacinação da população com doenças desmielinizantes do sistema nervoso central (SNC) contra infecções em geral e contra o coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), causador da COVID-19. Destaca-se a gravidade do atual momento frente ao avanço da COVID-19 em nosso País, o que torna mais evidente e importante a criação de guia de referência para orientação aos médicos, pacientes e autoridades de saúde pública quanto à vacinação, meio efetivo e seguro no controle de determinadas doenças infecciosa. O DCNI/ABN e o BCTRIMS recomendam que os pacientes com doenças desmielinizantes do SNC (ex., EM e NMOSD) sejam constantemente monitorados, quanto a atualização do seu calendário vacinal, especialmente, no início ou antes da mudança do tratamento com uma droga modificadora de doença (DMD). É importante também salientar que as vacinas são seguras e os médicos devem estimular o seu uso em todos os pacientes. Evidentemente, deve ser dada especial atenção às vacinas com vírus vivos atenuados. Por fim, é importante que os médicos verifiquem qual DMD o paciente está em uso e quando foi feita a sua última dose, pois cada fármaco pode interagir de forma diferente com a indução da resposta imune.

ABSTRACT The Scientific Department of Neuroimmunology of the Brazilian Academy of Neurology (DCNI/ABN) and Brazilian Committee for Treatment and Research in Multiple Sclerosis and Neuroimmunological Diseases (BCTRIMS) provide recommendations in this document for vaccination of the population with demyelinating diseases of the central nervous system (CNS) against infections in general and against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. We emphasize the seriousness of the current situation in view of the spread of COVID-19 in our country. Therefore, reference guides on vaccination for clinicians, patients, and public health authorities are particularly important to prevent some infectious diseases. The DCNI/ABN and BCTRIMS recommend that patients with CNS demyelinating diseases (e.g., MS and NMOSD) be continually monitored for updates to their vaccination schedule, especially at the beginning or before a change in treatment with a disease modifying drug (DMD). It is also important to note that vaccines are safe, and physicians should encourage their use in all patients. Clearly, special care should be taken when live attenuated viruses are involved. Finally, it is important for physicians to verify which DMD the patient is receiving and when the last dose was taken, as each drug may affect the induction of immune response differently.

https://doi.org/10.1590/0004-282x-anp-2021-0162 1 downloads

Nystagmus may be the first neurological sign in early stages of spinocerebellar ataxia type 3
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Gama, Maria Thereza Drumond

; Rezende Filho, Flávio Moura

; Rezende, Thiago Junqueira Ribeiro

; Braga Neto, Pedro

; França Junior, Marcondes Cavalcante

; Pedroso, José Luiz

; Barsottini, Orlando Graziani Povoas

Arquivos de Neuro-Psiquiatria

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Out 2021, Volume 79 Nº 10 Páginas 891 - 894

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Antecedentes: A ataxia espinocerebelar tipo 3 (SCA3) é a ataxia espinocerebelar de herança autossômica dominante mais comum em todo o mundo. Quase todos os pacientes com SCA3 têm nistagmo e/ou comprometimento das sácades. Objetivo: Investigar a presença de nistagmo como manifestação neurológica precoce, antes do surgimento da ataxia, em alguns pacientes com SCA3 nos primeiros seis meses de doença. Métodos: Foram avaliados 155 pacientes com diagnóstico clínico e molecular de SCA3, entre 2013 e 2020, em relação a sexo, idade, idade de início, duração da doença, expansão da repetição CAG, primeiro sintoma, presença de ataxia, pontuações nas escalas SARA e ICARS, e presença e caracterização de nistagmo. Resultados: Identificamos sete pacientes com SCA3 que apresentavam nistagmo isolado. A idade de início da doença nesses pacientes variou de 24 a 57 anos e a duração da doença variou de quatro a seis meses. Conclusões: O nosso estudo mostrou que o nistagmo pode ser o primeiro sinal neurológico na SCA3. Essa observação clínica reforça a ideia de que o processo neurodegenerativo nos pacientes com SCA3 pode se iniciar nas conexões do sistema vestibular ou no lobo floculonodular. Este estudo adiciona informações relevantes sobre características pré-sintomáticas na SCA3 e que podem servir de base para melhor entendimento da degeneração cerebral e para futuras terapias.

Abstract Background: Spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant spinocerebellar ataxia worldwide. Almost all patients with SCA3 exhibit nystagmus and/or saccades impairment. Objective: To investigate the presence of nystagmus as an early neurological manifestation, before ataxia, in some patients with SCA3 in the first six months of the disease. Methods: We evaluated a series of 155 patients with clinically and molecularly proven SCA3 between 2013 and 2020. Data regarding sex, age, age at onset, disease duration, CAG repeat expansion length, first symptom, presence of ataxia, scores on SARA and ICARS scales, and presence and characteristics of nystagmus were collected. Results: We identified seven patients with symptomatic SCA3 who presented with isolated nystagmus. In these seven individuals the age at onset ranged from 24 to 57 years, and disease duration from four to six months. Conclusions: Our study showed that nystagmus may be the first neurological sign in SCA3. This clinical observation reinforces the idea that the neurodegenerative process in SCA3 patients may start in vestibular system connections or in flocculonodular lobe. This study adds relevant information about pre-symptomatic features in SCA3 that may work as basis for a better understanding of brain degeneration and for future therapeutic clinical trials.

https://doi.org/10.1590/0004-282x-anp-2020-0386 99 downloads

Safe sex: ant defense does not interfere with pollination in passion flowers
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Ferreira, Tiago Valadares

; Izzo, Thiago Junqueira

; Teixido, Alberto López

Acta Botanica Brasilica

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Jun 2021, Volume 35 Nº 2 Páginas 290 - 297

Resumo: En | Texto: En | PDF: En

ABSTRACT Ant defense against floral enemies incurs a two-fold ant-pollinator conflict, both via pollinator deterrence and nectar or pollen collection by non-pollinating protective ants. Some ant-plants have physical barriers whereas others produce ant-repellent chemicals to avoid ant visitation to flowers and subsequent pollination interference. Passiflora coccinea is a hummingbird-pollinated myrmecophilous plant in which floral enemy repellence occurs without limiting ant access to open flowers. To test the hypothesis that ant activity is restricted within flowers to prevent contact with anthers, we compared ant defense response between reproductive (anthers and stigmas) and non-reproductive (bracts, corona and perianth) floral structures by combining an observational survey with an experimental approach. A few insect species were found to visit flowers without providing pollination service, mostly pollen-collecting bees and nectar-thieving butterflies landing on petals. Ants always attacked floral visitors that landed on non-reproductive structures, but they never attacked insects visiting reproductive structures as ants never accessed anthers. Our results suggest that the differential ant defense response is an adaptative process to prevent ant-pollinator conflict. The eventual mechanism that regulates this process could be closely linked to the corona of filaments that protects nectar chambers, simultaneously restricting ant access to nectar and pollen.

https://doi.org/10.1590/0102-33062020abb0408 238 downloads

The Program for Biodiversity Research in Brazil: The role of regional networks for biodiversity knowledge, dissemination, and conservation
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ROSA, CLARISSA

; BACCARO, FABRICIO

; CRONEMBERGER, CECILIA

; HIPÓLITO, JULIANA

; BARROS, CLAUDIA FRANCA

; RODRIGUES, DOMINGOS DE JESUS

; NECKEL-OLIVEIRA, SELVINO

; OVERBECK, GERHARD E.

; DRECHSLER-SANTOS, ELISANDRO RICARDO

; ANJOS, MARCELO RODRIGUES DOS

; FERREGUETTI, ÁTILLA C.

; AKAMA, ALBERTO

; MARTINS, MARLÚCIA BONIFÁCIO

; TOMAS, WALFRIDO MORAES

; SANTOS, SANDRA APARECIDA

; FERREIRA, VANDA LÚCIA

; CUNHA, CATIA NUNES DA

; PENHA, JERRY

; PINHO, JOÃO BATISTA DE

; SALIS, SUZANA MARIA

; DORIA, CAROLINA RODRIGUES DA COSTA

; PILLAR, VALÉRIO D.

; PODGAISKI, LUCIANA R.

; MENIN, MARCELO

; BÍGIO, NARCÍSIO COSTA

; ARAGÓN, SUSAN

; MANZATTO, ANGELO GILBERTO

; VÉLEZ-MARTIN, EDUARDO

; SILVA, ANA CAROLINA BORGES LINS E

; IZZO, THIAGO JUNQUEIRA

; MORTATI, AMANDA FREDERICO

; GIACOMIN, LEANDRO LACERDA

; ALMEIDA, THAÍS ELIAS

; ANDRÉ, THIAGO

; SILVEIRA, MARIA AUREA PINHEIRO DE ALMEIDA

; SILVEIRA, ANTÔNIO LAFFAYETE PIRES DA

; MESSIAS, MARILUCE REZENDE

; MARQUES, MARCIA C.M.

; PADIAL, ANDRE ANDRIAN

; MARQUES, RENATO

; BITAR, YOUSZEF O.C.

; SILVEIRA, MARCOS

; MORATO, ELDER FERREIRA

; PAGOTTO, RUBIANI DE CÁSSIA

; STRUSSMANN, CHRISTINE

; MACHADO, RICARDO BOMFIM

; AGUIAR, LUDMILLA MOURA DE SOUZA

; FERNANDES, GERALDO WILSON

; OKI, YUMI

; NOVAIS, SAMUEL

; FERREIRA, GUILHERME BRAGA

; BARBOSA, FLÁVIA RODRIGUES

; OCHOA, ANA C.

; MANGIONE, ANTONIO M.

; GATICA, AILIN

; CARRIZO, MARÍA CELINA

; RETTA, LUCÍA MARTINEZ

; JOFRÉ, LAURA E.

; CASTILLO, LUCIANA L.

; NEME, ANDREA M.

; RUEDA, CARLA

; TOLEDO, JOSÉ JULIO DE

; GRELLE, CARLOS EDUARDO VIVEIROS

; VALE, MARIANA M.

; VIEIRA, MARCUS VINICIUS

; CERQUEIRA, RUI

; HIGASHIKAWA, EMÍLIO MANABU

; MENDONÇA, FERNANDO PEREIRA DE

; GUERREIRO, QUÊZIA LEANDRO DE MOURA

; BANHOS, AUREO

; HERO, JEAN-MARC

; KOBLITZ, RODRIGO

; COLLEVATTI, ROSANE GARCIA

; SILVEIRA, LUÍS FÁBIO

; VASCONCELOS, HERALDO L.

; VIEIRA, CECÍLIA RODRIGUES

; COLLI, GUARINO RINALDI

; CECHIN, SONIA ZANINI

; SANTOS, TIAGO GOMES DOS

; FONTANA, CARLA S.

; JARENKOW, JOÃO A.

; MALABARBA, LUIZ R.

; RUEDA, MARTA P.

; ARAUJO, PUBLIO A.

; PALOMO, LUCAS

; ITURRE, MARTA C.

; BERGALLO, HELENA GODOY

; MAGNUSSON, WILLIAM E.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 Nº 2 elocation e20201604

Resumo: En | Texto: En | PDF: En

Abstract The Program for Biodiversity Research (PPBio) is an innovative program designed to integrate all biodiversity research stakeholders. Operating since 2004, it has installed long-term ecological research sites throughout Brazil and its logic has been applied in some other southern-hemisphere countries. The program supports all aspects of research necessary to understand biodiversity and the processes that affect it. There are presently 161 sampling sites (see some of them at Supplementary Appendix), most of which use a standardized methodology that allows comparisons across biomes and through time. To date, there are about 1200 publications associated with PPBio that cover topics ranging from natural history to genetics and species distributions. Most of the field data and metadata are available through PPBio web sites or DataONE. Metadata is available for researchers that intend to explore the different faces of Brazilian biodiversity spatio-temporal variation, as well as for managers intending to improve conservation strategies. The Program also fostered, directly and indirectly, local technical capacity building, and supported the training of hundreds of undergraduate and graduate students. The main challenge is maintaining the long-term funding necessary to understand biodiversity patterns and processes under pressure from global environmental changes.

https://doi.org/10.1590/0001-3765202120201604 1034 downloads

A Method to Assess the Risk of Sun Coral Invasion in Marine Protected Areas
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COUTO, THIAGO D. T. C.

; OMENA, ELIANNE P.

; OIGMAN-PSZCZOL, SIMONE S.

; JUNQUEIRA, ANDREA O.R.

Anais da Academia Brasileira de Ciências

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2021, Volume 93 elocation e20200583

Resumo: En | Texto: En | PDF: En

Abstract The safest and most efficient method of avoiding costs and impacts associated with biological invasions is to prevent the introduction and establishment of non-native species. In Brazil, two invasive coral species have been causing ecological, economic and social impacts: Tubastraea coccinea and Tubastraea tagusensis. This work presents a protocol to analyze the risk of invasion in Marine Protected Areas (MPAs) in the State of Rio de Janeiro considering the main vector of these species on the Brazilian coast. This protocol takes five risk factors into account: environmental similarity between the donor area and the possible receiving area; available substrate for colonization; proximity to the donor region; proximity and quantity of oil platforms and drill ships that passed by the analyzed MPAs and proximity and quantity of oil platforms and drill ships that anchored near the MPAs. Results must be used by decision-makers for a better management of Marine Protected Areas. The protocol we present can be applied to analyze the relative risk of invasion throughout the Brazilian coast, in order to prioritize areas for early detection and monitoring of the presence of sun corals.

https://doi.org/10.1590/0001-3765202120200583 91 downloads

Diagnostic discrepancies between emergency department admissions and hospital discharges among older adults: secondary analysis on a population-based survey
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Avelino-Silva, Thiago Junqueira

; Steinman, Michael Alan

Sao Paulo Medical Journal

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Out 2020, Volume 138 Nº 5 Páginas 359 - 367

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Older adults frequently experience nonspecific clinical features. However, there is limited evidence on how often admission diagnoses for hospitalized older patients are incorrect, potentially leading to treatment delays. OBJECTIVES: To determine the consistency between hospital admission and discharge diagnoses, and identify factors associated with diagnostic discrepancies in older adults. DESIGN AND SETTING: Population-based cohort study in the United States. We included adults aged ≥ 18 years who were admitted from emergency departments (EDs) to hospitals, identified using the 2005-2010 National Hospital Ambulatory Medical Survey, a nationally representative survey. METHODS: Three admission diagnoses and the principal discharge diagnosis were captured and classified as discrepant if they involved considerably different conditions within the same organ system, or different organ systems altogether. RESULTS: Each year, 12 million adults were hospitalized following ED visits in the United States; 45% were aged ≥ 65 years. These patients' mean age was 79 years and 58% were women. Diagnostic discrepancies between admission and discharge were more common among adults ≥ 65 years (12.5 versus 8.3%; P < 0.001). Certain admission diagnoses had particularly high rates of diagnostic discrepancies: 26-27% of patients presenting with mental disorders or with endocrine and metabolic diseases had substantial diagnostic discrepancies between admission and discharge. Substantial diagnostic discrepancy was independently associated with longer hospitalization and higher in-hospital mortality. CONCLUSION: One out of eight older adults hospitalized from EDs was discharged with a principal diagnosis differing considerably from the admission diagnosis. Given that missed or delayed diagnoses are a critical safety problem, clinicians should be vigilant and frequently cogitate alternative diagnostic possibilities.

https://doi.org/10.1590/1516-3180.0471.r1.05032020 387 downloads

10.

Alterações da ECA2 e Fatores de Risco para Gravidade da COVID-19 em Pacientes com Idade Avançada
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Tavares, Caio de Assis Moura

; Avelino-Silva, Thiago Junqueira

; Benard, Gil

; Cardozo, Francisco Akira Malta

; Fernandes, Juliana Ruiz

; Girardi, Adriana Castello Costa

; Jacob Filho, Wilson

Arquivos Brasileiros de Cardiologia

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Out 2020, Volume 115 Nº 4 Páginas 701 - 707

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20200487 3733 downloads

11.

Fungal and bacterial population from spent mushroom substrate used to cultivate tomato plants
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Moraes, Tatiana Silveira Junqueira de

; Costa, Lívia Martinez Abreu Soares

; Souza, Thiago Pereira

; Collela, Carolina Figueiredo

; Dias, Eustáquio Souza

Ciência e Agrotecnologia

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2020, Volume 44 elocation e010120

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO A produção de mudas de tomateiro é conduzida em substratos comerciais com propriedades adequadas para a boa formação da parte aérea e da raiz. O composto pós-cultivo de cogumelos (“Spent Mushroom Substrate” ou SMS) apresenta algumas vantagens em relação aos substratos comerciais para a qualidade das mudas de hortaliças, que podem ser proporcionados pela presença de uma rica microbiota, trazendo maior equilíbrio e maior competição com microrganismos patogênicos, além do controle biológico de patógenos e nematoides. É importante conhecer a microbiota presente nesse material e sua relação com a planta, para que essa associação possa ser feita da melhor maneira possível. Este trabalho teve como objetivo identificar a microbiota presente na rizosfera de mudas de tomate produzidas em SMS de cogumelos das espécies Agaricus subrufescens e Agaricus bisporus, acrescidos ou não de substrato comercial. A microbiota foi analisada por DGGE e amostras representativas de DNA foram sequenciadas para identificação das espécies. Entre os eucariotos, foram encontradas espécies de Chaetomium globosum, Arthrobotrys amerospora, predominantes no SMS de A. subrufescens, e Geastrum floriforme, Chrysosporium chiropterum, Pleurotus sp., e Trichosporon sp. no SMS de A. bisporus. Os procariontes apresentam maior diversidade, sugerindo um grande número de espécies ainda não classificadas ou cujas sequências ainda não estão disponíveis.

ABSTRACT The production of tomato seedlings is conducted on commercial substrates with adequate properties for the good formation of the aerial part and root. The Spent Mushroom Substrate, or SMS, presents advantages over commercial substrates regarding the quality of the vegetable seedlings, which may be provided by the presence of a rich microbiota, bringing higher balance and competition with pathogenic microorganisms, in addition to the biological control of pathogens and nematodes. It is important to know the microbiota present in this material and its relation to the plant, in order for this association to occur in the best manner possible. This work had the objective of identifying the microbiota present in the rhizosphere of tomato seedlings produced in SMS of Agaricus subrufescens and Agaricus bisporus mushrooms, added or not with commercial substrate. The microbiota was analyzed by DGGE and the representative samples were sequenced in order to identify the species. Among the eukaryotes, the Chaetomium globosum, Arthrobotrys amerospora species were predominant in the A. subrufescens SMS, and Geastrum floriforme, Chrysosporium chiropterum, Pleurotus sp., and Trichosporon sp. in the A. bisporus SMS. Prokaryotes are the most diverse group, suggesting a large number of species not yet classified or which sequences are not yet available.

https://doi.org/10.1590/1413-7054202044010120 1293 downloads

12.

Migraine in 746 patients with multiple sclerosis
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Fragoso, Yara Dadalti

; Adoni, Tarso

; Alves-Leon, Soniza V.

; Apostolos-Pereira, Samira L.

; Carneiro, Marcos A. Diniz

; Chikota, Edila M.

; Diniz, Denise Sisterolli

; Eboni, Audred C. B.

; Gomes, Sidney

; Gonçalves, Marcus Vinicius M.

; Goncalves, Ricardo Pereira

; Inojosa, José Luiz

; Junqueira, Thiago F.

; Machado, Suzana Costa

; Malfetano, Fabiola Rachid

; Mansur, Letícia Fezer

; Mendes, Maria Fernanda

; Muniz, Andre

; Nobrega Junior, Adaucto W.

; Olival, Guilherme Sciascia do

; Parolin, Monica Fiuza

; Pimentel, Maria Lucia V.

; Rocha, Cristiane Franklin

; Ruocco, Heloisa Helena

; Santos, Gutemberg C.

; Siquineli, Fabio

; Soares, José Otavio D.

; Sousa, Nise Alessandra C.

; Tauil, Carlos Bernardo

; Winckler, Thereza Cristina A.

Arquivos de Neuro-Psiquiatria

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Set 2019, Volume 77 Nº 9 Páginas 617 - 621

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Enxaqueca piora o sofrimento do paciente que tem esclerose múltipla (EM). ID-migraine é uma ferramenta útil para seleção de pacientes com enxaqueca e Migraine Disability Assessment (MIDAS) é um questionário que avalia o impacto da doença. O objetivo do presente estudo foi avaliar a presença e impacto de enxaqueca em pacientes com EM. Métodos: Pacientes diagnosticados com EM e tratados em clínicas especializadas foram convidados a responder um questionário online se também apresentassem cefaleia. Resultados: O estudo incluiu 746 participantes com cefaleia e EM que preencheram completamente as respostas. Foram 625 mulheres e 121 homens, sendo 69% dos pacientes com idade entre 20 e 40 anos. Enxaqueca foi identificada em 404 pacientes (54,1%) e moderado a grave impacto da doença foi observado em 68,3% dos casos. Conclusão: Enxaqueca é uma cefaleia primária frequente e incapacitante relatada por pacientes com EM.

ABSTRACT Migraine adds to the burden of patients suffering from multiple sclerosis (MS). The ID-migraine is a useful tool for screening migraine, and the Migraine Disability Assessment questionnaire can evaluate disease burden. The aim of the present study was to assess the presence and burden of migraine in patients with MS. Methods: Patients diagnosed with MS attending specialized MS units were invited to answer an online survey if they also experienced headache. Results: The study included 746 complete responses from patients with MS and headache. There were 625 women and 121 men, and 69% of all the patients were aged between 20 and 40 years. Migraine was identified in 404 patients (54.1%) and a moderate-to-high burden of disease was observed in 68.3% of the patients. Conclusion: Migraine is a frequent and disabling type of primary headache reported by patients with MS.

https://doi.org/10.1590/0004-282x20190100 1666 downloads

13.

Utilization of the Brazilian public health system by privately insured individuals: a literature review
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Fontenelle, Leonardo Ferreira

; Sarti, Thiago Dias

; Camargo, Maria Beatriz Junqueira de

; Maciel, Ethel Leonor Noia

; Barros, Aluísio J. D.

Cadernos de Saúde Pública

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2019, Volume 35 Nº 4 elocation e00004118

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

Resumo: Mais de um em cada quatro brasileiros têm planos de saúde, apesar de estes planos cobrirem majoritariamente os mesmos procedimentos do Sistema Único de Saúde (SUS). Esta revisão da literatura incluiu artigos e monografias publicados desde 1990 sobre a utilização do SUS por indivíduos com plano de saúde. Ao considerar conjuntamente a assistência ambulatorial e hospitalar, os brasileiros com planos de saúde utilizam o SUS em aproximadamente 13% das vezes em que recebem cuidados; aproximadamente 7% das pessoas que recebem cuidados pagos pelo SUS dispõem de planos de saúde (os achados variam de acordo com o tipo de serviço analisado e com os detalhes metodológicos dos estudos). O aumento da utilização do SUS está associado a: regiões menos desenvolvidas do país, planos de saúde com pior cobertura e pessoas com pior saúde. Os brasileiros com plano de saúde citam as limitações dos planos como o motivo pelo qual recorrem ao SUS. Em alguns casos os beneficiários de planos de saúde comercializados por hospitais filantrópicos (os quais também prestam assistência financiada pelo SUS) relatam acesso mais fácil à assistência financiada pelo SUS, comparado com aqueles sem plano de saúde. Pessoas com plano de saúde eventualmente citam a satisfação com a utilização do SUS, mas não a ponto do SUS se tornar a fonte de assistência preferida. Em resumo, para os brasileiros com plano de saúde, o SUS desempenha papel secundário no financiamento dos cuidados de saúde. Embora os planos de saúde pareçam deslocar parte da demanda por assistência para fora do SUS, esses mesmos planos tendem a restringir o caráter universal e equitativo do SUS.

Abstract: More than one in four Brazilians have private health insurance (PHI), even thought it covers mostly the same procedures as the Brazilian Unified National Health System (SUS). This literature review included articles and monographs published since 1990 about the utilization of SUS by privately insured individuals. Considering outpatient care and hospitalization, privately insured people in Brazil use SUS in approximately 13% of the times they receive health care, and approximately 7% of people receiving care paid by SUS are privately insured; these findings vary depending on the type of service studied and on study methods. Utilization of SUS is more frequent in less developed regions, by people with more restricted PHI plans and by people with worse health status. Privately insured people report the limitations of PHI plans as their reasons for resorting to SUS. Sometimes, beneficiaries of PHI plans owned by nonprofit hospitals (which also provide health care financed by SUS) have easier access to care than uninsured people financed by SUS. Anecdotally, privately insured people are satisfied with SUS, but not to the point of adopting SUS as their preferred source of care. In short, for privately insured people, SUS only plays a secondary role in their health care. Despite PHI taking over part of the SUS’s health care demand, PHI represents a restriction of the universal, equitable character of the SUS.

Resumen: Más de uno de cada cuatro brasileños tiene un seguro de salud privado (PHI), a pesar de que estos últimos cubren en su mayoría los mismos procedimientos que en el Sistema Unificado de Salud (SUS). Esta revisión de la literatura incluyó artículos y monografías publicadas desde 1990 sobre la utilización del SUS por parte de personas aseguradas mediante el sistema privado. Considerando atención ambulatoria junto a hospitalización, la población con seguro médico privado en Brasil utiliza el SUS aproximadamente un 13% de las veces que reciben atención médica; además, aproximadamente un 7% de la gente que recibe atención médica pagada a través del SUS tiene seguro privado. Los resultados varían con el tipo de servicio estudiado y con los detalles de los métodos de estudio. La frecuencia de utilización del SUS es mayor en las regiones menos desarrolladas, por parte de la población con planes de seguros de salud más limitados, y personas con peor salud. Las personas con seguros privados identifican las limitaciones de sus planes PHI como la razón por la que usan el SUS. Algunas veces, los beneficiarios de los planes PHI de hospitales sin fines de lucro (que también proveen servicios de salud financiados por el SUS) cuentan con un acceso más sencillo a los cuidados de salud sufragados por el SUS que las personas sin seguro. Anecdóticamente, la población con seguro de salud privado está satisfecha con la utilización que hacen del SUS, pero no hasta el extremo de que el SUS se trasforme en su principal vía para recibir servicios médicos. En resumen, para la población con seguro privado, el SUS juega un papel secundario en la financiación de la asistencia a sus cuidados de salud. Pese a que el PHI parece desviar del SUS parte de la demanda de cuidados de salud, el PHI representa una restricción del carácter universal y equitativo del SUS.

https://doi.org/10.1590/0102-311x00004118 1997 downloads

14.

Utilization of the Brazilian public health system by privately insured individuals: a literature review
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Fontenelle, Leonardo Ferreira

; Sarti, Thiago Dias

; Camargo, Maria Beatriz Junqueira de

; Maciel, Ethel Leonor Noia

; Barros, Aluísio J. D.

Cadernos de Saúde Pública

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2019, Volume 35 Nº 4 elocation e00004118

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

https://doi.org/10.1590/0102-311x00004118

15.

Effects of concurrent training associated with N-acetylcysteine on bone density of spontaneously hypertensive rats
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Rogerio, Murillo Martins

; Santos, Lucas Silva

; Garcia, Thiago Alves

; Ozaki, Guilherme Akio Tamura

; Fernandes, Rodrigo Antonio

; Castoldi, Robson Chacon

; Louzada, Mario Jefferson Quirino

; Okoshi, Katashi

; Junqueira, Adriana

Motriz: Revista de Educação Física

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2019, Volume 25 Nº 2 elocation e101938

Resumo: En | Texto: En | PDF: En

Abstract Aim: The present study aimed to analyze the effects of N-acetylcysteine supplementation associated with concurrent training on the bone mineral density of spontaneously hypertensive elderly rats. Methods: For the present study, 28 male spontaneously hypertensive rats, six months old, were distributed in the following groups: control (C, n=7); control + N-acetylcysteine (CNAC, n=7); concurrent training (T, n=7); and concurrent training+N-acetylcysteine (TNAC, n=7). The concurrent training was composed of aerobic training on a treadmill and resistance training in the same training session, three times a week. Animals of the NAC groups received a dose equivalent to 120 mg/kg/day orally for eight weeks. The animals in the trained groups underwent training for eight weeks. The animals were evaluated at the beginning and end of the experiment. After euthanasia, the tibias and femurs were submitted to bone densitometry analysis in an X-ray dual emission device. Results: Lower weight variation was observed in the trained animals and a reduction in pressure values in all groups, but without a statistical difference (p> 0.05). The animals in the T and TNAC groups presented a better performance in the physical tests (p <0.05). In relation to bone, the NAC groups demonstrated a decrease in femoral bone density when compared to groups C and T. Finally, all experimental groups demonstrated an increase in tibial bone density, but with no statistical difference (p>0.05). Conclusion: The animals in group T demonstrated better performance in the physical tests. In addition, the NAC caused a reduction in the bone mineral density of the femur.

https://doi.org/10.1590/s1980-6574201900010020 728 downloads

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