SUMMARY BACKGROUND: Cerebrovascular accident (or stroke) and ischemic heart disease are the the major causes of death in the world. It is estimated that about 85% of strokes are ischemic in origin. Reperfusion therapy in the acute phase of ischemic stroke with a recombinant human tissue plasminogen activator is effective, but some factors influence the success of this treatment. OBJECTIVE: The aim of this study was to evaluate clinical aspects and possible determinants for reperfusion after venous thrombolysis. METHODS: This is a retrospective, cross-sectional, observational study based on a review of hospital records of inpatients diagnosed with ischemic stroke treated with intravenous thrombolysis, the main outcome being reperfusion or not. RESULTS: Data from this study revealed a predominance of females in the group of reperfused patients and males in the non-reperfused group, both maintaining moderate severity on the National Institutes of Health Stroke Scale and admission without statistical significance (p>0.18). In addition, the mean admission severity score was 13.2 for the group of reperfused patients and 14.2 for those not reperfused, and the mean ejection fraction of both groups was within normal functionality, with a mean of 0.50 for reperfused patients and 0.62 for non-reperfused patients. CONCLUSION: We found an association between successful venous chemical thrombolysis reperfusion and lower mortality in patients with acute stroke.

Resumen Objetivo Evaluar el nivel de incapacidad funcional e identificar los factores asociados en las personas después de un accidente cerebrovascular isquémico. Métodos Cohorte prospectiva, realizada en un hospital de referencia en neurología, con 224 personas con accidente cerebrovascular isquémico. La recopilación de datos se llevó a cabo entre marzo y octubre de 2019. Se acompañó a los participantes durante la internación, momento en que se recopilaron las variables sociodemográficas y clínicas mediante la utilización de instrumentos específicos, y se los contactó 90 días después, por teléfono, para aplicar el Índice de Barthel modificado. En el análisis se aplicó estadística descriptiva y la prueba χ2 de Pearson. Se adoptó significación estadística de 5 %. Resultados La mayoría presentó algún nivel de incapacidad funcional (58,5 %), de los cuales el 29,5 % presentó dependencia moderada y el 29,0 % dependencia severa o grave. Las siguientes variables fueron asociadas a un mayor nivel de incapacidad: sexo femenino (p=0,011), tiempo de llegada al hospital de referencia mayor o igual a 4,5 h (p=0,017), accidente cerebrovascular previo (p=0,031), no haber realizado trombólisis (p=0,023), tener hipertensión arterial (p=0,032) y mayor gravedad estimada por la National Institute of Health Stroke Scale (p=0,000). Conclusión Predominó la dependencia de moderada a grave. La gravedad del evento, evento previo, hipertensión, no realización de trombólisis, retraso de la llegada al hospital y sexo femenino fueron las variables asociadas a un mayor nivel de incapacidad funcional. isquémico prospectiva neurología 22 2019 internación específicos 9 teléfono modificado χ Pearson 58,5 585 58 (58, %, , %) 295 29 29, 290 0 grave p=0,011, p0011 p p=0,011 011 (p=0,011) 45 4 4, p=0,017, p0017 p=0,017 017 (p=0,017) p=0,031, p0031 p=0,031 031 (p=0,031) p=0,023, p0023 p=0,023 023 (p=0,023) p=0,032 p0032 032 (p=0,032 p=0,000. p0000 p=0,000 . 000 (p=0,000) 2 201 58, (58 p001 p=0,01 01 (p=0,011 (p=0,017 p003 p=0,03 03 (p=0,031 p002 p=0,02 02 (p=0,023 (p=0,03 p000 p=0,00 00 (p=0,000 20 (5 p00 p=0,0 (p=0,01 (p=0,02 (p=0,0 (p=0,00 ( p0 p=0, (p=0, p=0 (p=0 p= (p= (p

Abstract Objective To assess the functional disability level and identify associated factors in people after Ischemic Cerebral Vascular Accident. Methods A prospective cohort, carried out in a reference hospital in neurology with 224 people with ischemic stroke. Data collection took place between March and October 2019. Participants were followed up during hospitalization, when sociodemographic and clinical variables were collected using specific instruments and contacted after 90 days, by telephone call, to apply the Modified Barthel Index. In the analysis, descriptive statistics and Pearson’s chi-square test were applied. Statistical significance of 5% was adopted. Results Most had some degree of functional disability (58.5%), with 29.5% having moderate dependence and 29.0% having severe dependence. The variables being female (p=0.011), time of arrival at the reference hospital greater than or equal to 4.5 hours (p=0.017), previous stroke (p=0.031), not having undergone thrombolysis (p=0.023), having high blood pressure (p=0.032) and greater severity estimated by the National Institute of Health Stroke Scale (p=0.000) were associated with a higher disability level. Conclusion Moderate to severe dependence predominated. The severity of the event, previous event, hypertension, non-submission to thrombolysis, delay in arriving at the hospital and female gender were associated with a higher functional disability level. Accident cohort 22 2019 hospitalization 9 days call Index analysis Pearsons Pearson s chisquare chi square applied 5 adopted 58.5%, 585 58.5% , 58 (58.5%) 295 29 29.5 290 0 29.0 p=0.011, p0011 p p=0.011 011 (p=0.011) 45 4 4. p=0.017, p0017 p=0.017 017 (p=0.017) p=0.031, p0031 p=0.031 031 (p=0.031) p=0.023, p0023 p=0.023 023 (p=0.023) p=0.032 p0032 032 (p=0.032 p=0.000 p0000 000 (p=0.000 predominated event hypertension nonsubmission non submission 2 201 58.5 (58.5% 29. p001 p=0.01 01 (p=0.011 (p=0.017 p003 p=0.03 03 (p=0.031 p002 p=0.02 02 (p=0.023 (p=0.03 p=0.00 p000 00 (p=0.00 20 58. (58.5 p00 p=0.0 (p=0.01 (p=0.02 (p=0.0 (58. p0 p=0. (p=0. (58 p=0 (p=0 (5 p= (p= ( (p

Resumo Objetivo Avaliar o nível de incapacidade funcional e identificar os fatores associados em pessoas após Acidente Vascular Cerebral Isquêmico. Métodos Coorte prospectiva, realizada em hospital de referência em neurologia, com 224 pessoas com acidente vascular cerebral isquêmico. A coleta de dados ocorreu entre março a outubro de 2019. Os participantes foram acompanhados durante a internação, quando as variáveis sociodemográficas e clínicas foram levantadas empregando-se instrumentos específicos e contatados após 90 dias, por ligação telefônica, para aplicação do Índice de Barthel modificado. Na análise, aplicou-se estatística descritiva e o teste Qui-quadrado de Pearson. Adotou-se significância estatística de 5%. Resultados A maioria apresentou algum grau de incapacidade funcional (58,5%), sendo que 29,5% apresentaram dependência moderada e 29,0% severa ou grave. As variáveis sexo feminino (p=0,011), tempo de chegada ao hospital de referência maior ou igual a 4,5h (p=0,017), Acidente vascular cerebral prévio (p=0,031), não ter realizado trombólise (p=0,023), ter hipertensão arterial (p=0,032) e maior gravidade estimada pela National Institute of Health Stroke Scale (p=0,000) foram associadas a maior nível de incapacidade. Conclusão Predominou a dependência de moderada a grave. A gravidade do evento, evento prévio, hipertensão, não submissão à trombólise, retardo à chegada ao hospital e sexo feminino foram associados a maior nível de incapacidade funcional. Isquêmico prospectiva neurologia 22 isquêmico 2019 internação empregandose empregando se 9 dias telefônica modificado análise aplicouse aplicou Quiquadrado Qui quadrado Pearson Adotouse Adotou 5 5% 58,5%, 585 58,5% , 58 (58,5%) 295 29 29,5 290 0 29,0 grave p=0,011, p0011 p p=0,011 011 (p=0,011) 45h h 4 5h p=0,017, p0017 p=0,017 017 (p=0,017) p=0,031, p0031 p=0,031 031 (p=0,031) p=0,023, p0023 p=0,023 023 (p=0,023) p=0,032 p0032 032 (p=0,032 p=0,000 p0000 000 (p=0,000 2 201 58,5 (58,5% 29, p001 p=0,01 01 (p=0,011 (p=0,017 p003 p=0,03 03 (p=0,031 p002 p=0,02 02 (p=0,023 (p=0,03 p=0,00 p000 00 (p=0,00 20 58, (58,5 p00 p=0,0 (p=0,01 (p=0,02 (p=0,0 (58, p0 p=0, (p=0, (58 p=0 (p=0 (5 p= (p= ( (p

RESUMEN Creado en el día 2 de diciembre de 1837, el Imperial Colegio Pedro II fue la más importante institución de enseñanza secundaria de Brasil en los ochocientos. La institución formó parte de la elite letrada imperial y su currículo expresaba la preeminencia de un proyecto de invención de la identidad nacional pautado en la noción de civilización y amparada por el énfasis en el mundo antiguo. En este sentido, este artículo tiene como escopo la enseñanza de Geografía Antigua pensada por el maestro Fray Camillo Monserrate en el Imperial Colegio Pedro II entre 1850 y 1854. Para eso, movilizo los programas de las disciplinas y anotaciones producidas por el maestro, con el intento de comprender las finalidades atribuidas a los usos de la antigüedad en el currículo de la enseñanza secundaria en la edificación de un ideal de civilización y las inquietaciones cerca de la construcción del equilibrio de los contenidos entre la Europa e la América. 1837 ochocientos antiguo sentido 185 1854 eso América 183 18 1

ABSTRACT Created on December 2, 1837, the Imperial Colégio Pedro II was the most important secondary education institution in 19th century Brazil. The institution formed part of the imperial literate elite and its curriculum expressed the prominence of a project of invention of national identity based on the notion of civilization and supported by an emphasis on the ancient world. In this sense, this article has as its scope the teaching of Ancient Geography thought by Professor Frei Camillo Monserrate at the Imperial College Pedro between 1850 and 1854. to the uses of antiquity in the secondary education curriculum in the construction of an ideal of civilization and the concerns about the construction of a balance of contents between Europe and America. 2 1837 th Brazil world sense 185 1854 America 183 18 1

RESUMO Criado no dia 2 de dezembro de 1837, o Imperial Colégio Pedro II foi a mais importante instituição de ensino secundário do Brasil oitocentista. A instituição formou parte da elite letrada imperial e o seu currículo expressava a proeminência de um projeto de invenção da identidade nacional pautado na noção de civilização e amparada pela ênfase no mundo antigo. Nesse sentido, este artigo tem como escopo o ensino de Geografia Antiga pensado pelo professor frei Camillo Monserrate na instituição entre 1850 e 1854. Para isso, mobilizo os programas das disciplinas e anotações produzidas pelo docente, com o intuito de compreender as finalidades atribuídas aos usos da Antiguidade no currículo do ensino secundário na edificação de um ideal de civilização e as inquietações acerca da construção do equilíbrio de conteúdos entre a Europa e a América. 1837 oitocentista antigo sentido 185 1854 isso docente América 183 18 1

Resumo Objetivo Esta pesquisa buscou revisar as evidências atuais sobre intervenções de terapia ocupacional para promover independência nas atividades de vida diária e atividades instrumentais de vida diária em indivíduos com Mielomeningocele. Método Foram seguidos os critérios do PRISMA e pesquisadas as bases de dados PubMed, Web of Science, Cochrane Library, Embase, Lilacs, Scielo, PEDro e OTseeker, utilizando-se os descritores disrafismo espinhal, espinha bífida, mielomeningocele associados à reabilitação, independência, atividades de vida diária e terapia ocupacional. Resultados Dos 523 artigos encontrados, 19 preencheram os critérios de inclusão/exclusão. Destes, 18 foram intervenções e um de revisão, resultando na seleção de 18 estudos. A análise quantitativa e descritiva revelou que o maior número de estudos publicados foi de intervenção baseada em acampamento, orientação cognitiva CO-OP para o desempenho ocupacional diário, programa de educação integrativa em dois passos e sistema móvel de saúde e reabilitação. As intervenções baseadas em acampamento, CO-OP e terapia baseada em ocupação mostraram maior independência dos participantes. Conclusão Esta revisão apresentou uma síntese das intervenções que visam melhorar a independência nas AVDs e AIVDs em pessoas com MMC, seus referenciais teóricos e elementos comuns que favorecem a efetividade. Mielomeningocele PubMed Science Library Embase Lilacs Scielo OTseeker utilizandose utilizando se espinhal bífida reabilitação 52 encontrados 1 inclusãoexclusão inclusão exclusão inclusão/exclusão Destes acampamento COOP CO OP diário participantes MMC efetividade 5

Abstract: Objective This research reviews current evidence on occupational therapy interventions for promoting independence in activities of daily living and instrumental activities of daily living in individuals with Myelomeningocele. Method The PRISMA criteria were adopted and, PubMed, Web of Science, Cochrane Library, Embase, Lilacs, Scielo, PEDro and OTseeker were searched, using the descriptors spinal dysraphism, spina bifida and myelomeningocele associated with rehabilitation, independence, activities of daily living and occupational therapy. Results Of the 523 articles found, 19 met the inclusion/exclusion criteria. Of these, 18 were interventions and one a review, resulting in the selection of 18 studies. A quantitative and descriptive analysis revealed that the highest number of published studies were camp-based intervention, Cognitive Orientation to Daily Occupational Performance and Two-Step Integrative Education Program and Mobile Health and Rehabilitation system. The camp-based interventions, CO-OP and occupation-based therapy showed increased independence of the participants. Conclusion This review presented a synthesis of interventions aimed at improving independence in ADLs and IADLs in people with MMC, their theoretical frameworks and common elements that favor effectiveness. Abstract Myelomeningocele PubMed Science Library Embase Lilacs Scielo searched dysraphism rehabilitation 52 found 1 inclusionexclusion inclusion exclusion these campbased camp based intervention TwoStep Two Step system COOP CO OP occupationbased occupation participants MMC effectiveness 5

Abstract Objective To identify interventions in the literature that assist in promoting functionality in older adults during the hospital-to-home transition. Method Integrative literature review with searches conducted between October and November 2022, in the following databases: MEDLINE, Lilacs, IBECS, BDENF, WoS, SCOPUS, CINAHL, and PEDro, using the MeSH terms: Aged, Transitional Care, and Functional Status, in any language, without temporal restriction, employing boolean operators OR and AND. Result A total of 2,123 papers were identified, with nine meeting the inclusion criteria, resulting in four categories: Health education; Active involvement of older adults and family caregivers; Multidisciplinary team involvement; Follow-up care post-hospital discharge. Conclusion The continuity of care post-hospital discharge through interventions aimed at maintaining and restoring functionality is a strategy that strengthens the autonomy and independence of older adults. hospitaltohome hospital to home transition 2022 databases MEDLINE Lilacs IBECS BDENF WoS SCOPUS CINAHL PEDro terms Aged Care Status language restriction AND 2123 2 123 2,12 identified criteria categories education caregivers Followup Follow up posthospital post 202 212 12 2,1 20 21 1 2,

Resumo Objetivo Identificar na literatura, intervenções que auxiliam na promoção da funcionalidade da pessoa idosa durante a transição hospital domicílio. Método Revisão integrativa de literatura com buscas entre outubro e novembro de 2022, nas bases de dados: MEDLINE, Lilacs, IBECS, BDENF, WoS, SCOPUS, CINAHL e PEDro, com os MeSh: Aged, Transitional Care e Functional Status, em qualquer idioma, sem recorte temporal, com operador booleano OR e AND. Resultado: Identificou-se 2.123 artigos, nove atenderam aos critérios de inclusão, emergindo quatro categorias: Educação em saúde; Envolvimento ativo das pessoas idosas e cuidadores familiares; Atuação de equipe multidisciplinar; Acompanhamento após alta hospitalar. Conclusão A continuidade dos cuidados após alta hospitalar através de intervenções para manter e recuperar a funcionalidade é uma estratégia que fortalece a autonomia e a independência das pessoas idosas. domicílio 2022 dados MEDLINE Lilacs IBECS BDENF WoS SCOPUS PEDro MeSh Aged Status idioma temporal AND Resultado Identificouse Identificou se 2123 2 123 2.12 artigos inclusão categorias saúde familiares multidisciplinar 202 212 12 2.1 20 21 1 2.

Abstract Background: Evidence shows that systematizing the therapeutic approach to patients with post-stroke dysphagia reduces complications significantly. Objective: To design and implement a multimodal intervention to systematize an evidence-based approach to patients with dysphagia. Methodology: A continuous quality improvement project for nursing care was implemented in a rehabilitation inpatient unit in five phases: analysis of the model in use, design of the intervention, implementation, assessment, and dissemination of results. Data were collected through documentary analysis, audits, and focus groups. Results: There was an increase of 39.59% in the identified nursing foci and 45.33% in interventions. The translation of evidence into practice was also observed at the level of assessment, systematization of practices, and monitoring during meals and oral hygiene. Conclusion: This Project contributed to translating knowledge into practice, particularly concerning the success of the therapeutic plan, specifically in terms of dysphagia, for patients being cared for.

Resumen Marco contextual: Está demostrado que la sistematización del enfoque terapéutico de las personas con trastorno de la deglución tras un accidente cerebrovascular (ACV) tiene un impacto significativo en la reducción de las complicaciones. Objetivo: Diseñar e implementar una intervención multimodal para aplicar la evidencia en la sistematización del enfoque de la persona con trastorno de la deglución. Metodología: Proyecto de mejora continua de la calidad de los cuidados de enfermería desarrollado en una unidad hospitalaria de rehabilitación, en cinco fases: análisis del modelo en uso, diseño de la intervención, implementación, evaluación y puesta en común de los resultados. Los datos se recogieron mediante análisis de documentos, auditorías y grupos de discusión. Resultados: Se observa un incremento del 39,59% en los focos de enfermería identificados y del 45,33% en las intervenciones, así como la transposición a la práctica de la evidencia a nivel de la evaluación, la sistematización de las prácticas, el seguimiento durante las comidas y la higiene bucodental. Conclusión: Este proyecto contribuyó a la transposición de los conocimientos a la práctica, es decir, al éxito del plan terapéutico para la persona atendida, concretamente en el contexto del trastorno de la deglución.

Resumo Enquadramento: Existe evidência de que a sistematização da abordagem terapêutica à pessoa com deglutição comprometida após o acidente vascular cerebral (AVC) tem um impacte significativo na redução de complicações. Objetivo: Conceber e implementar uma intervenção multimodal para a implementação da evidência, na sistematização da abordagem à pessoa com deglutição comprometida. Metodologia: Projeto de melhoria contínua da qualidade dos cuidados de enfermagem desenvolvido num serviço de internamento de reabilitação, em cinco fases: análise do modelo em uso, construção da intervenção, implementação, avaliação e partilha dos resultados. Para a recolha de dados utilizaram-se a análise à documentação, a auditoria e grupos focais. Resultados: Verificou-se um incremento de 39,59% nos focos de enfermagem identificados e de 45,33% de intervenções, assim como a transposição para a prática da evidência ao nível da avaliação, da sistematização das práticas, acompanhamento durante as refeições e higiene oral. Conclusão: Este projeto contribuiu para a transposição do conhecimento para a prática, nomeadamente para o sucesso do plano terapêutico da pessoa alvo dos cuidados, concretamente no âmbito da deglutição comprometida.

Research to identify plant bioactive compounds led to the evolution of extraction methods. This study optimized ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE) to extract the flavonoids of Croton grewioides Baill. species contributing to characterize the polar extract profile and understand the antioxidant potential of these plant constituents. The use of experimental design and statistical treatments enabled the determination of the ideal conditions for each technique. The extracts of five accessions of C. grewioides were obtained under the optimized extraction conditions and were analyzed using ultra high-resolution mass spectrometry (FT-Orbitrap MS) operating at negative ionization mode for flavonoids detection. The accurate experimental mass obtained to the main compounds was used to attribute the molecular formula. Chemical structures of the main compounds detected were proposed using structure data bases. Chemometric analysis were performed with two FT-Orbitrap MS spectra samples using the identified metabolites and, the antioxidant activity data, showing that for this species the MAE was most effective in extracting the antioxidant compounds. It was possible to propose the structures for forty compounds in the C. grewioides extracts, demonstrating the excellent performance of the FT-Orbitrap MS in providing information on the chemical profile of polar compounds in plant extracts. methods ultrasoundassisted ultrasound assisted UAE (UAE microwaveassisted microwave (MAE Baill constituents technique C highresolution high resolution FTOrbitrap FT Orbitrap detection formula bases

Resumo Estudos em escala global apontam que as mudanças climáticas são uma realidade concreta a ser enfrentada. Dados atuais revelam uma variação em medidas de variáveis hidrológicas em biomas, tal como, o bioma Mata Atlântica. Esses estudos revelam tendências em mudanças acentuadas no padrão de períodos de secas e cheias, com consequente desaparecimento de ecossistemas. Nesse contexto, foi estruturada uma oficina visando levar estudantes de Ensino Médio a refletirem sobre as mudanças climáticas a partir de conceitos da Física, Matemática e Ciências Naturais, com um enfoque na articulação entre pensar e fazer, com o referencial da Ciência Cidadã e da Base Nacional Comum Curricular. Partindo de procedimentos de coleta de dados de pesquisa desenvolvida no INMA - Instituto Nacional da Mata Atlântica, estudantes engajaram na proposta apresentada. A oficina foi realizada tanto em sala de aula quanto em um hotspot de biodiversidade na Mata Atlântica, o Parque do Museu de Biologia Prof. Mello Leitão (MBML), sede do INMA, em Santa Teresa, Estado do Espírito Santo e contou com a participação de 118 alunos de 6 turmas da 1ª série do Ensino Médio da EEEFM José Pinto Coelho que coletaram dados para o cálculo da vazão do Córrego São Pedro que passa pelo Parque do Museu e atrás da Escola. Após as atividades, resultados preliminares revelam que os alunos apresentam dificuldades em realizar matemática básica, média aritmética, equações e conversão de unidades. Em relação às mudanças climáticas, foi possível observar que apresentaram um conhecimento básico sobre a temática.

Abstract Studies on a global scale point out that climate change is a reality to be faced. Current data reveal a change in hydrological variable measures in biomes, such as the Atlantic Forest. These studies reveal trends in accentuated changes in the pattern of periods of droughts and floods, with the consequent disappearance of ecosystems. In this context, a workshop was set up to encourage high school students to reflect on climate change based on concepts from Physics, Mathematics and Natural Sciences, with a focus on the articulation between thinking and doing, with the reference of Citizen Science and the Base National Common Curriculum. Based on research data collection procedures developed at INMA - Instituto Nacional da Mata Atlântica, students engaged in the presented proposal. The workshop was held both in the classroom and in a biodiversity hotspot in the Atlantic Forest, the Museum of Biology Prof. Mello Leitão (MBML), INMA's headquarters, in Santa Teresa, State of Espírito Santo and was attended by 118 students from 6 classes of the 1st grade of high school at EEEFM José Pinto Coelho who collected data to calculate the flow of the Stream São Pedro that passes through the park of the Museum and behind the school. After the activities, the results revealed that students have difficulties in performing basic math calculations, arithmetic average, equations e unit conversion. In relation to climate change, it was possible to observe that the students presented a basic knowledge on the subject.

Abstract Background: Latin America has registered cases in children under 14 years of age, which seem few compared to older age groups but are relevant since the child and youth population have been indirectly receiving the most decisive impact of the pandemic. Ensuring the most significant protection for this age group is essential. Methods: This is an ecological study of 10 Latin American and the Caribbean countries to study protecting children and adolescents during the COVID-19 pandemic. Using the information from UNICEF, a coverage analysis was done, and a new variable score was proposed. Also, a multiple linear regression model was tailored to evaluate the relationship between confirmed cases by 100k of COVID-19 (0-14 year population) and the performance of the countries and some key indicators. Results: A strong and statistically significant correlation (r = 0.79; p value 0.005) between the increased coverage of child helplines and a greater number of school closures. Relationship of confirmed cases by COVID-19 and stringency index with a coef B = −2163.6, [CI −3122.1; −1205.1]; p value = 0.010. Cases and healthcare access with a coef B = −17459.7, [CI −25630.1; −9289.5]. Conclusions: Experts say other pandemics will come, and this emergency must be turned into an opportunity. It is vital to strengthen protection programs for the population, especially vulnerable people, such as children and young people.

Resumo Contexto: A América Latina registou casos em crianças menores de 14 anos, que parecem poucos em comparação com os grupos etários mais velhos, mas que são relevantes uma vez que a população infantil e juvenil tem vindo a receber indiretamente o impacto mais decisivo da pandemia. Assegurar a proteção mais significativa para este grupo etário é essencial. Métodos: Este é um estudo ecológico de 10 países da América Latina e das Caraíbas para estudar a proteção de crianças e adolescentes durante a pandemia da COVID-19. Utilizando a informação da UNICEF, foi feita uma análise de cobertura e foi proposta uma nova pontuação variável. Além disso, foi adequado um modelo de regressão linear múltipla para avaliar a relação entre casos confirmados por 100k de COVID-19 (0 a 14 anos de população) e o desempenho dos países e alguns indicadores chave. Resultados: Uma correlação forte e estatisticamente significativa (r = 0,79; p-valor 0.005) entre o aumento da cobertura das linhas de ajuda às crianças e um maior número de encerramentos de escolas. Relação de casos confirmados pela COVID-19 e índice de rigueur com um coeficiente B = −2163,6, [CI −3122,1; −1205,1]; p-valor = 0.010. Casos e acesso aos cuidados de saúde com um coeficiente B = −17459.7, [CI −25630.1; −9289.5]. Conclusões: Os peritos dizem que outras pandemias virão e esta emergência deve ser transformada numa oportunidade. É vital reforçar os programas de proteção para a população, especialmente as pessoas vulneráveis, tais como crianças e jovens.

Abstract The cryopreservation of jaguar semen must be improved to produce high-quality biobanking doses. Until now, the rare studies of semen freezing in the species have only evaluated glycerol, always with a significant reduction in sperm quality in thawed semen. The purpose of this study was to assess the efficacy of three cryoprotectants, dimethylsulfoxide (DMSO), glycerol (GLY), and methanol (MET), in the cryopreservation of jaguar semen in an LDL-based extender, as well as the effect of thawing temperature on dosage quality. Five mature males with a history of reproduction were used. On the males, an infrared thermal image (IRT) was captured, the spicules and testes were analyzed, and the CASA system was used to evaluate the quality of fresh and thawed sperm. The superficial IRT was 4.6 ± 1.2 °C cooler than the anal sphincter, and the semen measured between 27.3 and 28.7 °C shortly after exiting the urethra. The total motility of fresh sperm was 55.3 ± 22.6%, and progressive motility was 36.3 ± 18%. The total motility of thawed sperm was 5.28 ± 2.51%, 4.49 ± %2.49, and 0.51 ± 0.62% for DMSO, GLY, and MET, respectively. DMSO and GLY performed better than MET, and there was no difference in thawing temperature (37°C 30 s vs. 50°C 12 s). All animals exhibit a considerable level of morphological changes in sperm. Low amounts of total and progressive motility were found in the thawed sperm. Males with a high level of sperm morphological changes were found to be fertile, but the lone male with normospermia was infertile. Thus, we contest the applicability of the commonly used morphological classification for bovines to felid species. highquality doses now cryoprotectants , (DMSO) (GLY) MET (MET) LDLbased LDL based extender (IRT captured analyzed 46 4 6 4. 1 2 1. C sphincter 273 27 3 27. 287 28 7 28. urethra 553 55 55. 226 22 22.6% 363 36 36. 18 18% 528 5 5.2 251 51 2.51% 449 49 4.4 249 %2.49 051 0 0.5 062 62 0.62 respectively 37°C 37C 37 vs 50C 50 s. . s) fertile infertile Thus (DMSO (GLY (MET 22.6 52 5. 25 2.51 44 24 %2.4 05 0. 06 0.6 22. 2.5 %2. 2. %2 %

ABSTRACT BACKGROUND: Stroke is a major cause of death and functional disability worldwide. Knowledge of the associated factors is essential for defining education, management, and healthcare strategies. OBJECTIVE: To analyze the association between arrival time at a neurology referral hospital (ATRH) and functional disability in patients with ischemic stroke 90 days after the event. DESIGN AND SETTING: Prospective cohort study conducted at a public institution of higher education in Brazil. METHODS: This study included 241 people aged ≥ 18 years who presented ischemic stroke. The exclusion criteria were death, inability to communicate without companions who could answer the research questions, and > 10 days since ictus. Disability was assessed using the Rankin score (mR). Variables for which associations showed a P value ≤ 0.20 in bivariate analysis were tested as modifiers between ATRH and disability. Significant interaction terms were used for multivariate analysis. Multivariate logistic regression analysis was performed with all variables, arriving at the complete model and adjusted beta measures. The confounding variables were included in the robust logistic regression model, and Akaike’s Information Criterion was adopted to choose the final model. The Poisson model assumes a statistical significance of 5% and risk correction. RESULTS: Most participants (56.0%) arrived at the hospital within 4.5 hours of symptom onset, and 51.7% presented with mRs of 3 to 5 after 90 days of ictus. In the multivariate model, ATRH ≥ 4.5 hours and females were associated with more significant disability. CONCLUSIONS: Arrival at the referral hospital 4.5 hours after the onset of symptoms or wake-up stroke was an independent predictor of a high degree of functional disability. BACKGROUND worldwide management strategies OBJECTIVE (ATRH 9 event SETTING Brazil METHODS 24 1 questions ictus mR. mR . (mR) 020 0 20 0.2 measures Akaikes Akaike s correction RESULTS 56.0% 560 56 (56.0% 45 4 4. 517 51 7 51.7 CONCLUSIONS wakeup wake up 2 (mR 02 0. 56.0 (56.0 51. 56. (56. (56 (5 (