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RESUMO: A mastite bovina é a doença mais impactante na indústria de laticínios e é caracterizada por uma complexidade de agentes causais, os quais têm revelado uma variação geográfica entre regiões e países. Os patógenos relacionados à mastite têm sido tradicionalmente classificados como contagiosos ou ambientais, com base na fonte de infecção ou origem e nas vias de transmissão. Além disso, a gravidade das infecções mamárias tem sido associada à virulência dos patógenos, e ao estado imunológico e nutricional dos animais. Considerando esse cenário, investigamos os agentes etiológicos, os escores de gravidade clínica e os dados de dias em lactação (DEL) em 4.273 casos clínicos de mastite bovina em dez fazendas de grande porte, quatro localizadas no sudoeste do estado de São Paulo e seis no sul do Estado de Minas Gerais, Brasil. Streptococcus dysgalactiae (283/4.273 = 6,6%), Escherichia coli (190/4.273 = 4,4%), Prototheca spp. (112/4.273 = 2,6%) e Streptococcus uberis (95/4.273 = 2,2%) foram os patógenos predominantes isolados. Entre os 4.273 casos clínicos, a pontuação de gravidade clínica estava disponível em 43,8% (1.871/4.273) dos animais. Desses, 69,8% (1.306/1.871), 27,3% (510/1.871) e 2,9% (55/1.871) foram classificados como leves, moderados e graves, respectivamente. Os patógenos foram observados principalmente em amostras obtidas durante os primeiros 100 dias em lactação, e a gravidade clínica foi principalmente classificada como leve. Nossos resultados contribuem para a identificação etiológica, a pontuação de gravidade clínica e os aspectos de ordenha de vacas com mastite em fazendas leiteiras com histórico de infecções mamárias clínicas. RESUMO causais países ambientais transmissão disso animais cenário etiológicos DEL (DEL 4273 4 273 4.27 porte Gerais Brasil 283/4.273 2834273 283 (283/4.27 6,6%, 66 6,6% , 6 6,6%) 190/4.273 1904273 190 (190/4.27 4,4%, 44 4,4% 4,4%) spp 112/4.273 1124273 112 (112/4.27 2,6% 26 2 95/4.273 954273 95 (95/4.27 2,2% 22 isolados 438 43 8 43,8 1.871/4.273 18714273 1 871 (1.871/4.273 Desses 698 69 69,8 1.306/1.871, 13061871 1.306/1.871 306 (1.306/1.871) 27 3 27,3 510/1.871 5101871 510 (510/1.871 29 9 2,9 55/1.871 551871 55 (55/1.871 leves graves respectivamente 10 leve etiológica clínicas 427 4.2 283/4.27 283427 28 (283/4.2 6,6 190/4.27 190427 19 (190/4.2 4,4 112/4.27 112427 11 (112/4.2 2,6 95/4.27 95427 (95/4.2 2,2 43, 1.871/4.27 1871427 87 (1.871/4.27 69, 1306187 1.306/1.87 30 (1.306/1.871 27, 510/1.87 510187 51 (510/1.87 2, 55/1.87 55187 5 (55/1.87 42 4. 283/4.2 28342 (283/4. 6, 190/4.2 19042 (190/4. 4, 112/4.2 11242 (112/4. 95/4.2 9542 (95/4. 1.871/4.2 187142 (1.871/4.2 130618 1.306/1.8 (1.306/1.87 510/1.8 51018 (510/1.8 55/1.8 5518 (55/1.8 283/4. 2834 (283/4 190/4. 1904 (190/4 112/4. 1124 (112/4 95/4. 954 (95/4 1.871/4. 18714 (1.871/4. 13061 1.306/1. (1.306/1.8 510/1. 5101 (510/1. 55/1. 551 (55/1. 283/4 (283/ 190/4 (190/ 112/4 (112/ 95/4 (95/ 1.871/4 1871 (1.871/4 1306 1.306/1 (1.306/1. 510/1 (510/1 55/1 (55/1 283/ (283 190/ (190 112/ (112 95/ (95 1.871/ 187 (1.871/ 130 1.306/ (1.306/1 510/ (510/ 55/ (55/ (28 (19 (11 (9 1.871 18 (1.871 13 1.306 (1.306/ (510 (55 (2 (1 ( 1.87 (1.87 1.30 (1.306 (51 (5 1.8 (1.8 1.3 (1.30 1. (1. (1.3

ABSTRACT: Bovine mastitis is the most impacting disease of dairy industry, and it is characterized by a complexity of causal agents, which have revealed a geographical variation among regions and countries. The mastitis-related pathogens have been traditionally classified as contagious or environmental, based on habits of the microorganisms and transmission routes. Besides, the severity of mammary infections has been associated with the virulence of the pathogens, and immune and nutritional status of the hosts. Considering this scenario, we investigated the etiological pattern, clinical severity scores, and days in milk (DIM) data in 4,273 clinical cases of bovine mastitis among ten large-dairy farms located in Brazil. Streptococcus dysgalactiae (283/4,273 = 6.6%), Escherichia coli (190/4,273 = 4.4%), Prototheca spp. (112/4,273 = 2.6%), and Streptococcus uberis (95/4,273 = 2.2%) were the predominant pathogens isolated. Among 4,273 clinical cases, clinical severity score was available in 43.8% (1,871/4,273) animals. From these, 69.8% (1,306/1,871), 27.3% (510/1,871), and 2.9% (55/1,871) were scored as mild, moderate, and severe, respectively. Pathogens were observed mainly in samples obtained during the first 100 days in milk, and clinical severity scored mainly as mild. Our results contributed to the etiological identification, clinical severity scoring, and milking aspects of mastitic cows in dairy farms with a history of clinical mammary infections. ABSTRACT industry agents countries mastitisrelated related environmental routes Besides hosts scenario pattern scores DIM (DIM 4273 4 273 4,27 largedairy large Brazil 283/4,273 2834273 283 (283/4,27 6.6%, 66 6.6% , 6 6.6%) 190/4,273 1904273 190 (190/4,27 4.4%, 44 4.4% 4.4%) spp 112/4,273 1124273 112 (112/4,27 2.6%, 26 2.6% 2 2.6%) 95/4,273 954273 95 (95/4,27 2.2% 22 isolated 438 43 8 43.8 1,871/4,273 18714273 1 871 (1,871/4,273 animals these 698 69 69.8 1,306/1,871, 13061871 1,306/1,871 306 (1,306/1,871) 27 3 27.3 510/1,871, 5101871 510/1,871 510 (510/1,871) 29 9 2.9 55/1,871 551871 55 (55/1,871 mild moderate severe respectively 10 identification scoring 427 4,2 283/4,27 283427 28 (283/4,2 6.6 190/4,27 190427 19 (190/4,2 4.4 112/4,27 112427 11 (112/4,2 2.6 95/4,27 95427 (95/4,2 2.2 43. 1,871/4,27 1871427 87 (1,871/4,27 69. 1306187 1,306/1,87 30 (1,306/1,871 27. 510187 510/1,87 51 (510/1,871 2. 55/1,87 55187 5 (55/1,87 42 4, 283/4,2 28342 (283/4, 6. 190/4,2 19042 (190/4, 4. 112/4,2 11242 (112/4, 95/4,2 9542 (95/4, 1,871/4,2 187142 (1,871/4,2 130618 1,306/1,8 (1,306/1,87 51018 510/1,8 (510/1,87 55/1,8 5518 (55/1,8 283/4, 2834 (283/4 190/4, 1904 (190/4 112/4, 1124 (112/4 95/4, 954 (95/4 1,871/4, 18714 (1,871/4, 13061 1,306/1, (1,306/1,8 5101 510/1, (510/1,8 55/1, 551 (55/1, 283/4 (283/ 190/4 (190/ 112/4 (112/ 95/4 (95/ 1,871/4 1871 (1,871/4 1306 1,306/1 (1,306/1, 510/1 (510/1, 55/1 (55/1 283/ (283 190/ (190 112/ (112 95/ (95 1,871/ 187 (1,871/ 130 1,306/ (1,306/1 510/ (510/1 55/ (55/ (28 (19 (11 (9 1,871 18 (1,871 13 1,306 (1,306/ (510/ (55 (2 (1 ( 1,87 (1,87 1,30 (1,306 (510 (5 1,8 (1,8 1,3 (1,30 (51 1, (1, (1,3

https://doi.org/10.1590/0103-8478cr20230555

As dimensões do fenômeno produtivismo acadêmico e seu efeito danoso na atividade científica
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Guimarães, José Augusto Chaves

; Hilário, Carla Mara

; Grácio, Maria Cláudia Cabrini

Em Questão

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2024, Volume 30 elocation e138768

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Os processos avaliativos da vida acadêmica, que são predominantemente quantitativos, têm levado os pesquisadores a um desvirtuamento em sua produtividade, em muitos casos, por meio de atitudes antiéticas, conduzindo ao denominado produtivismo acadêmico. Nesse sentido, objetiva-se examinar o fenômeno do produtivismo acadêmico, buscando identificar suas dimensões no âmbito da atribuição da autoria, da configuração das publicações, das citações e das publicações predatórias, e discutir sobre seus efeitos para o processo de comunicação científica. Para tanto, se vale de uma revisão crítica da literatura, centrando-se em aspectos relativos à sociologia da ciência e à ética na produçãocienmtífica. Destaca-se a necessidade de que sejam considerados elementos de natureza qualitativa na avaliação da produtividade científica, refletindo um comprometimento ético com a prática científica e conclui-se que o produtivismo acadêmico tem conduzido à prática de valoração da publicação como objetivo último da pesquisa e da produção intelectual restringindo a atividade investigativa e a produção de conhecimento a uma quantificação de resultados.

Abstract The evaluation processes of academic life, which are predominantly quantitative, have led researchers to distort their productivity, in many cases, through unethical attitudes, leading to the so-called academic productivism. In this sense, this article aims to examine the phenomenon of academic productivism, seeking to identify its dimensions in the context of authorship attribution, the configuration of publications, citations, and predatory publications, and discuss its effects on the scientific communication process. To do so, it uses a critical review of the literature, focusing on issues relating to the sociology of science and ethics in scientific production. The article highlights the need to consider elements of a qualitative nature when evaluating scientific productivity, reflecting an ethical commitment to scientific practice. It concludes that academic productivism has led to the practice of valuing publication as the ultimate objective of research and intellectual production, restricting investigative activity and the production of knowledge to a quantification of results.

https://doi.org/10.1590/1808-5245.30.138768

Oral health of an indigenous population in northeastern Brazil: a cross-sectional Study of the Fulni-ô ethnic group
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Koike, Bruna Del Vechio

; Valões, Rosangela Maria Pereira

; Cazal, Claudia

; Pereira, Vanessa Cardoso

; Fraga, Carlos Alberto de Carvalho

; Carmo, Rodrigo Feliciano do

; Pereira, Meireane Firmino

; Guimarães, Manoel Pereira

; Souza, Carlos Dornels Freire de

; Armstrong, Anderson da Costa

Sao Paulo Medical Journal

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2024, Volume 142 Nº 1 elocation e2022355

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: There is a lack of studies evaluating the oral health of traditional indigenous communities in Brazil. OBJECTIVES: Thus, the objective of this study was to describe the oral health characteristics of the indigenous Fulni-ô ethnic group in Northeast Brazil. DESIGN AND SETTING: A cross-sectional observational investigation was conducted within the Project on Atherosclerosis among Indigenous Populations. METHODS: This study included participants of both sexes from the Fulni-ô ethnic group. The participants included in this investigation underwent a comprehensive oral health evaluation by a registered and experienced dentist to assess oral health and identify potentially malignant oral lesions. Participants with suspicious lesions were referred for biopsy. Shapiro-Wilk, Mann-Whitney, and Student’s t-tests were used, and measures of central tendency and dispersion were described. Statistical significance was 5%. RESULTS: A total of 104 individuals were included in this study. The prevalence of the use of tobacco derivatives was 94.0%, with similarities between sexes. The prevalence of oral changes in this study population was 84.4%. Fifty-one individuals who underwent oral reassessment were referred for oral lesion biopsy. CONCLUSIONS: This study demonstrated a high prevalence of oral alterations in the Fulni-ô population. Histopathological analyses indicated the presence of mild oral epithelial dysplasia in five cases.

https://doi.org/10.1590/1516-3180.2022.0355.r1.10042023

Clinical epidemiological and laboratory investigation in co-infection with COVID-19 and tuberculosis coinfection co infection COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Belchior, Ana Carulina Guimarães

; Freitas Neto, Antônio Martins de

; Gusmao, Grassyelly Silva

; Santos, Evelin Jaqueline Lima dos

; Lemos, Everton Ferreira

; Pompilio, Mauricio Antonio

; Volpe-Chaves, Cláudia Elizabeth

; Brito, Eliana da Costa Alvarenga de

; Oliveira, Everton Falcão de

; Carreiro, Ana Caroline Blanco

; Paniago, Anamaria Mello Miranda

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e65

Resumo: En | Texto: En | PDF: En

ABSTRACT Currently, COVID-19 and tuberculosis (TB) are the deadliest infectious diseases worldwide. Their synergy, form of presentation, morbidity, and mortality are data that have been scarcely explored. Thus, this study aimed to characterize the clinical, epidemiological, and laboratory factors of this co-infection and to analyze the factors associated with the active TB among COVID-19 cases. A case-control study was conducted with a retrospective survey of 21 laboratory-confirmed COVID-19/TB co-infected patients (case group) and 21 COVID-19 patients (control group). The study included participants from eight hospitals in Campo Grande city, capital of Mato Grosso do Sul State, Brazil, from March 2020 to March 2022. Association analysis and binomial logistic regression were employed with statistical significance set at p≤0.05. From the 21 identified cases of COVID-19/TB co-infection, we found a more frequent association with HIV infection than the control-group, without worsening the outcome. COVID-19/TB patients had less dyspnea and less need for mechanical ventilation compared to the cases with COVID-19 only. On the other hand, COVID-19/TB patients had higher levels of C-reactive protein and lower hemoglobin levels, the latter variable was independently associated with COVID-19/TB. Among the clinical differences presented among COVID-19/TB co-infected patients, despite the association with HIV and lower clinical repercussions, only lower hemoglobin levels were associated with COVID-19/TB. Currently COVID19 COVID 19 COVID-1 (TB worldwide synergy presentation morbidity explored Thus epidemiological coinfection co casecontrol case control 2 laboratoryconfirmed confirmed COVID19/TB COVID19TB COVIDTB 19/TB coinfected infected group group. . city State Brazil 202 2022 p005 p 0 05 p≤0.05 coinfection, infection, controlgroup, controlgroup group, control-group outcome hand Creactive C reactive COVID19/TB. 19/TB. repercussions COVID1 1 COVID- 19TB 20 p00 p≤0.0 p0 p≤0. p≤0 p≤

https://doi.org/10.1590/s1678-9946202466065

Face mask use and viral load in patients with mild symptoms of COVID-19 COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Costa, Murilo Soares

; Alves, Claudia Regina Lindgren

; Fonseca, Flávio Guimarães da

; Sato, Hugo Itaru

; Rocha, Raissa Prado

; Carvalho, Alex Fiorini de

; Lourenço, Karine Lima

; Guimarães, Nathalia Sernizon

; Machado, Elaine Leandro

; Teixeira, Santuza Maria Ribeiro

; Tupinambás, Unaí

; Takahashi, Ricardo Hiroshi Caldeira

einstein (São Paulo)

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2024, Volume 22 elocation eAO0495

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: Previous studies indicated that face masks reduce the probability of infection by SARS-CoV-2 but did not examine the relationship between SARS-CoV-2 viral load and mask usage. This study analyzed this relationship. Methods: This cross-sectional study evaluated patients admitted to a public Emergency Care Unit in Belo Horizonte, MG, Brazil, between October 2020 and March 2021. Convenience samples were recruited during the study period. Adult patients with COVID-19 symptoms were invited to participate after being examined by a physician according to the Emergency Care Unit routine. This study included 441 adults with mild symptoms diagnosed with COVID-19 via RT-PCR, who were tested until the 14th day after symptom onset. Participants were interviewed about mask usage, oropharyngeal swabs were collected, and the SARS-CoV-2 viral load was measured using RT-PCR. The difference between the SARS-CoV-2 viral load in the groups of individuals who regularly used and did not use masks was subjected to a hypothesis test. Results: Of the patients who had swabs collected 1-5 days after symptom onset, 64.9% of those not using masks regularly and 45.5% of those using masks regularly presented a high SARS-CoV-2 viral load. This difference was statistically significant (p=0.0073). Considering only the patients who had swabs collected 4-8 days after symptom onset, 44.1% of those not using masks regularly and 30.8% of those using masks regularly presented a high SARS-CoV-2 viral load; this difference was statistically significant (p=0.0364). Conclusion: When people who regularly wear a face mask contract COVID-19, they have a significantly lower probability of having a high viral load of SARS-CoV-2 compared to those who do not regularly wear masks. Objective SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- usage Methods crosssectional cross sectional Horizonte MG Brazil 202 2021 period COVID19 COVID 19 COVID-1 routine 44 RTPCR, RTPCR RT PCR, PCR RT-PCR th onset RTPCR. PCR. test Results 15 1 5 1- 649 64 9 64.9 455 45 45.5 p=0.0073. p00073 p p=0.0073 . 0 0073 (p=0.0073) 48 4 8 4- 44.1 308 30 30.8 p=0.0364. p00364 p=0.0364 0364 (p=0.0364) Conclusion COVID19, 19, SARS-CoV 20 COVID1 COVID- 6 64. 45. p0007 p=0.007 007 (p=0.0073 44. 3 30. p0036 p=0.036 036 (p=0.0364 p000 p=0.00 00 (p=0.007 p003 p=0.03 03 (p=0.036 p00 p=0.0 (p=0.00 (p=0.03 p0 p=0. (p=0.0 p=0 (p=0. p= (p=0 (p= (p

https://doi.org/10.31744/einstein_journal/2024ao0495

Fractal analysis and assessment of lacunarity in mandibular osteoradionecrosis: a cross-sectional study with control group osteoradionecrosis crosssectional cross sectional
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Barcelos, Natália Santos

; Brasileiro, Cláudia Borges

; Abreu, Lucas Guimarães

; Mendonça, Elismauro Francisco

; Sousa-Neto, Sebastião Silvério

; Sousa, Sílvia Ferreira de

; Mesquita, Ricardo Alves

; Caldeira, Patrícia Carlos

Brazilian Oral Research

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2024, Volume 38 elocation e114

Resumo: En | Texto: En | PDF: En

Abstract The objective of this study was to evaluate the fractal dimension (FD) and lacunarity of the mandibular bone, comparing patients with and without osteoradionecrosis (ORN). In a cross-sectional study with a control group, 25 patients were included and divided into a case group (with ORN, n = 14) and a control group (without ORN, n = 11). A digital panoramic radiograph taken after the end of radiotherapy (RT) was evaluated for each patient. FD and lacunarity of the mandibular bone were determined using ImageJ software. Descriptive, bivariate, and ROC curve analyses were performed. Cohen's d effect sizes were calculated. Significance was established at p < 0.05. The mean FD and lacunarity values were not significantly different between the groups. The area under the curve for FD and lacunarity were 0.579 and 0.661, respectively. The cut-off point for FD was ≤1.1714 and for lacunarity, > 0.3821, correctly classifying the majority of cases and controls. Most participants in the case group (63.6%) had a FD ≤ 1.1714 and the majority of participants in the control group (63.6%) had a FD >1.1714 (p = 0.395). For lacunarity, most individuals in the case group (72.7%) had a value > 0.3821 and most participants in the control group (63.6%) had a value ≤ 0.3821 (p = 0.198). In conclusion, the FD and lacunarity values did not show statistically significant differences between patients with and without ORN. However, the moderate and large magnitude of the effects seem to indicate that the results may be clinically relevant. (FD ORN . (ORN) crosssectional cross sectional 2 14 11. 11 11) RT (RT patient software Descriptive bivariate performed Cohens Cohen s calculated 005 0 05 0.05 groups 0579 579 0.57 0661 661 0.661 respectively cutoff cut off 11714 1 1714 ≤1.171 03821 3821 controls 63.6% 636 63 6 (63.6% 1.171 >1.171 0.395. 0395 0.395 395 0.395) 72.7% 727 72 7 (72.7% 0.382 0.198. 0198 0.198 198 0.198) conclusion However relevant (ORN 00 0.0 057 57 0.5 066 66 0.66 1171 171 ≤1.17 0382 382 63.6 (63.6 1.17 >1.17 039 0.39 39 72.7 (72.7 0.38 019 0.19 19 0. 5 06 0.6 117 17 ≤1.1 038 38 63. (63. 1.1 >1.1 03 0.3 3 72. (72. 01 0.1 ≤1. (63 1. >1. (72 ≤1 (6 >1 (7 (

https://doi.org/10.1590/1807-3107bor-2024.vol38.0114

Brazilian consensus recommendations on the diagnosis and treatment of autoimmune encephalitis in the adult and pediatric populations
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Dutra, Lívia Almeida

; Silva, Pedro Victor de Castro

; Ferreira, João Henrique Fregadolli

; Marques, Alexandre Coelho

; Toso, Fabio Fieni

; Vasconcelos, Claudia Cristina Ferreira

; Brum, Doralina Guimarães

; Pereira, Samira Luisa dos Apóstolos

; Adoni, Tarso

; Rocha, Leticia Januzi de Almeida

; Sampaio, Leticia Pereira de Brito

; Sousa, Nise Alessandra de Carvalho

; Paolilo, Renata Barbosa

; Pizzol, Angélica Dal

; Costa, Bruna Klein da

; Disserol, Caio César Diniz

; Pupe, Camila

; Valle, Daniel Almeida do

; Diniz, Denise Sisterolli

; Abrantes, Fabiano Ferreira de

; Schmidt, Felipe da Rocha

; Cendes, Fernando

; Oliveira, Francisco Tomaz Meneses de

; Martins, Gabriela Joca

; Silva, Guilherme Diogo

; Lin, Katia

; Pinto, Lécio Figueira

; Santos, Mara Lúcia Schimtz Ferreira

; Gonçalves, Marcus Vinícius Magno

; Krueger, Mariana Braatz

; Haziot, Michel Elyas Jung

; Barsottini, Orlando Graziani Povoas

; Nascimento, Osvaldo José Moreira do

; Nóbrega, Paulo Ribeiro

; Proveti, Priscilla Mara

; Castilhos, Raphael Machado do

; Daccach, Vanessa

; Glehn, Felipe von

Arquivos de Neuro-Psiquiatria

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2024, Volume 82 Nº 7 elocation s00441788586

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Antecedentes Encefalites autoimunes (EAIs) são um grupo de doenças inflamatórias caracterizadas pela presença de anticorpos contra antígenos neuronais e gliais, que ocasionam sintomas psiquiátricos subagudos, queixas de memória e distúrbios anormais do movimento. A maioria dos pacientes é jovem, e o atraso no tratamento está associado a pior prognóstico. Objetivo Com o apoio da Academia Brasileira de Neurologia (ABN) e da Sociedade Brasileira de Neurologia Infantil (SBNI), desenvolvemos um consenso sobre o diagnóstico e o tratamento da EAIs no Brasil utilizando a metodologia Delphi. Métodos Um total de 25 especialistas, incluindo neurologistas e neurologistas infantis, foram convidados a participar. Resultados Os especialistas concordaram que os pacientes com critérios de possíveis EAIs devem ser submetidos ao rastreio de anticorpos antineuronais no soro e no líquido cefalorraquidiano (LCR) por meio das técnicas de ensaio baseado em tecidos (tissue-based assay, TBA, em inglês) e ensaio baseado em células (cell-based assay, CBA, em inglês). As crianças também devem ser submetidas ao rastreio de de anticorpo contra a glicoproteína da mielina de oligodendrócitos (anti-myelin oligodendrocyte glycoprotein, anti-MOG, em inglês). O tratamento deve ser iniciado dentro das primeiras 4 semanas dos sintomas, sendo as opções de primeira linha metilprednisolona combinada com imunoglobulina intravenosa (IGIV) ou plasmaférese. O tratamento de segunda linha inclui rituximabe e ciclofosfamida. Bortezomib e tocilizumab são opções de tratamento de terceira linha. A maioria das crises epilépticas nas EAIs são sintomáticas, e os fármacos anticrise podem ser desmamadas após a fase aguda. Em relação à encefalite antirreceptor de N-metil-D-aspartato (anti-N-methyl-D-aspartate receptor, anti-NMDAR, em inglês), os especialistas concordaram que agentes imunossupressores orais não devem ser usados. Os pacientes devem ser avaliados na fase aguda e pós-aguda mediante escalas funcionais e cognitivas, como Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Modified Rankin Scale (mRS), e Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusão Esta pesquisa oferece evidências tangíveis do manejo efetivo de pacientes com EAIs no sistema de saúde Brasileiro. (EAIs gliais subagudos movimento jovem prognóstico ABN (ABN SBNI, SBNI , (SBNI) Delphi 2 infantis participar LCR (LCR tissuebased tissue based assay TBA inglês cellbased cell CBA inglês. . antimyelin anti myelin glycoprotein antiMOG, antiMOG MOG, MOG anti-MOG IGIV (IGIV plasmaférese ciclofosfamida sintomáticas NmetilDaspartato N metil D aspartato antiNmethylDaspartate methyl aspartate receptor antiNMDAR, antiNMDAR NMDAR, NMDAR anti-NMDAR inglês, usados pósaguda pós cognitivas MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) Brasileiro (SBNI (MMSE (MoCA (mRS (CASE

Abstract Background Autoimmune encephalitis (AIE) is a group of inflammatory diseases characterized by the presence of antibodies against neuronal and glial antigens, leading to subacute psychiatric symptoms, memory complaints, and movement disorders. The patients are predominantly young, and delays in treatment are associated with worse prognosis. Objective With the support of the Brazilian Academy of Neurology (Academia Brasileira de Neurologia, ABN) and the Brazilian Society of Child Neurology (Sociedade Brasileira de Neurologia Infantil, SBNI), a consensus on the diagnosis and treatment of AIE in Brazil was developed using the Delphi method. Methods A total of 25 panelists, including adult and child neurologists, participated in the study. Results The panelists agreed that patients fulfilling criteria for possible AIE should be screened for antineuronal antibodies in the serum and cerebrospinal fluid (CSF) using the tissue-based assay (TBA) and cell-based assay (CBA) techniques. Children should also be screened for anti-myelin oligodendrocyte glucoprotein antibodies (anti-MOG). Treatment should be started within the first 4 weeks of symptoms. The first-line option is methylprednisolone plus intravenous immunoglobulin (IVIG) or plasmapheresis, the second-line includes rituximab and/or cyclophosphamide, while third-line treatment options are bortezomib and tocilizumab. Most seizures in AIE are symptomatic, and antiseizure medications may be weaned after the acute stage. In anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the panelists have agreed that oral immunosuppressant agents should not be used. Patients should be evaluated at the acute and postacute stages using functional and cognitive scales, such as the Mini-Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), the Modified Rankin Scale (mRS), and the Clinical Assessment Scale in Autoimmune Encephalitis (CASE). Conclusion The present study provides tangible evidence for the effective management of AIE patients within the Brazilian healthcare system. (AIE antigens symptoms complaints disorders young prognosis Academia ABN Sociedade Infantil SBNI, SBNI , SBNI) method 2 neurologists CSF (CSF tissuebased tissue based TBA (TBA cellbased cell CBA (CBA techniques antimyelin anti myelin antiMOG. antiMOG MOG . (anti-MOG) firstline line IVIG (IVIG plasmapheresis secondline second andor cyclophosphamide thirdline third tocilizumab symptomatic stage antiNmethylDaspartate N methyl D aspartate antiNMDAR NMDAR (anti-NMDAR used scales MiniMental Mini Mental MMSE, MMSE (MMSE) MoCA, MoCA (MoCA) mRS, mRS (mRS) CASE. CASE (CASE) system (anti-MOG (MMSE (MoCA (mRS (CASE

https://doi.org/10.1055/s-0044-1788586

Can habits and behaviors predict colonization by community-associated MRSA in patients admitted to a Brazilian hospital? communityassociated community associated hospital
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Pinheiro, Marcos Vinicius de Barros

; Cavalcante, Fernanda Sampaio

; Ferreira, Dennis de Carvalho

; Guimarães, Ana Carolina Fonseca

; Ferreira, Adriana Lúcia Pires

; Costa, Claudia Regina da Santos, Kátia Regina Netto dos Nouér, Simone Aranha Rangel, Ana Pereira Castiñeiras, Anna Carla Gonzalez, Christiany Moçali Freire, Joana Guimarães, Luiz Felipe Batista, Raquel

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e31

Resumo: En | Texto: En | PDF: En

ABSTRACT This study aimed to identify factors associated with colonization by community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in adult patients admitted to a Brazilian hospital. This is a cross-sectional study, in which patients underwent a nasal swab and were asked about hygiene behavior, habits, and clinical history. Among the 702 patients, 180 (25.6%) had S. aureus and 21 (2.9%) MRSA. The factors associated with MRSA colonization were attending a gym (OR 4.71; 95% CI; 1.42 – 15.06), smoking habit in the last year (OR 2.37; 95% CI; 0.88 – 6.38), previous hospitalization (OR 2.18; CI 95%; 0.89 – 5.25), and shared personal hygiene items (OR 1.99; 95% CI; 0.71 – 5.55). At the time of admission, colonization by CA-MRSA isolates was higher than that found in the general population. This can be an important public health problem, already endemic in hospitals, whose factors such as those associated with habits (smoking cigarettes) and behaviors (team sports practice and activities in gyms) have been strongly highlighted. These findings may help developing infection control policies, allowing targeting patients on higher-risk populations for MRSA colonization. communityassociated community methicillinresistant methicillin resistant CAMRSA CA (CA-MRSA hospital crosssectional cross sectional behavior history 70 18 25.6% 256 25 6 (25.6% S 2 2.9% 29 9 (2.9% OR 4.71 471 4 71 95 142 1 42 1.4 15.06, 1506 15.06 , 15 06 15.06) 2.37 237 37 088 0 88 0.8 6.38, 638 6.38 38 6.38) 2.18 218 089 89 5.25, 525 5.25 5 5.25) 1.99 199 99 071 0.7 5.55. 555 5.55 . 55 5.55) admission population problem hospitals cigarettes team gyms highlighted policies higherrisk risk 7 25.6 (25.6 2.9 (2.9 4.7 47 14 1. 150 15.0 2.3 23 3 08 8 0. 63 6.3 2.1 52 5.2 1.9 19 07 5.5 25. (25. 2. (2. 4. 15. 6. 5. (25 (2 (

https://doi.org/10.1590/s1678-9946202466031

Diretrizes Brasileiras de Medidas da Pressão Arterial Dentro e Fora do Consultório – 2023 202 20 2
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Feitosa, Audes Diogenes de Magalhães

; Barroso, Weimar Kunz Sebba

; Mion Junior, Decio

; Nobre, Fernando

; Mota-Gomes, Marco Antonio

; Jardim, Paulo Cesar Brandão Veiga

; Amodeo, Celso

; Oliveira, Adriana Camargo

; Alessi, Alexandre

; Sousa, Ana Luiza Lima

; Brandão, Andréa Araujo

; Pio-Abreu, Andrea

; Sposito, Andrei C.

; Pierin, Angela Maria Geraldo

; Paiva, Annelise Machado Gomes de

; Spinelli, Antonio Carlos de Souza

; Machado, Carlos Alberto

; Poli-de-Figueiredo, Carlos Eduardo

; Rodrigues, Cibele Isaac Saad

; Forjaz, Claudia Lucia de Moraes

; Sampaio, Diogo Pereira Santos

; Barbosa, Eduardo Costa Duarte

; Freitas, Elizabete Viana de

; Cestario, Elizabeth do Espirito Santo

; Muxfeldt, Elizabeth Silaid

; Lima Júnior, Emilton

; Campana, Erika Maria Gonçalves

; Feitosa, Fabiana Gomes Aragão Magalhães

; Consolim-Colombo, Fernanda Marciano

; Almeida, Fernando Antônio de

; Silva, Giovanio Vieira da

; Moreno Júnior, Heitor

; Finimundi, Helius Carlos

; Guimarães, Isabel Cristina Britto

; Gemelli, João Roberto

; Barreto-Filho, José Augusto Soares

; Vilela-Martin, José Fernando

; Ribeiro, José Marcio

; Yugar-Toledo, Juan Carlos

; Magalhães, Lucélia Batista Neves Cunha

; Drager, Luciano F.

; Bortolotto, Luiz Aparecido

; Alves, Marco Antonio de Melo

; Malachias, Marcus Vinícius Bolívar

; Neves, Mario Fritsch Toros

; Santos, Mayara Cedrim

; Dinamarco, Nelson

; Moreira Filho, Osni

; Passarelli Júnior, Oswaldo

; Vitorino, Priscila Valverde de Oliveira

; Miranda, Roberto Dischinger

; Bezerra, Rodrigo

; Pedrosa, Rodrigo Pinto

; Paula, Rogerio Baumgratz de

; Okawa, Rogério Toshiro Passos

; Póvoa, Rui Manuel dos Santos

; Fuchs, Sandra C.

; Lima, Sandro Gonçalves de

; Inuzuka, Sayuri

; Ferreira-Filho, Sebastião Rodrigues

; Fillho, Silvio Hock de Paffer

; Jardim, Thiago de Souza Veiga

; Guimarães Neto, Vanildo da Silva

; Koch, Vera Hermina Kalika

; Gusmão, Waléria Dantas Pereira

; Oigman, Wille

; Nadruz Junior, Wilson

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 Nº 4 elocation e20240113

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20240113

10.

Chitosan/Poly(2-(diisopropylamino)ethyl Methacrylate-Based pH-Sensitive Magnetic Composite for Application in Avermectins Adsorption in Aqueous Medium Chitosan/Poly2diisopropylaminoethyl ChitosanPoly2diisopropylaminoethyl ChitosanPolydiisopropylaminoethyl Chitosan/Poly 2 diisopropylamino ethyl Chitosan Poly MethacrylateBased Methacrylate Based pHSensitive pH Sensitive Poly2diisopropylaminoethyl diisopropylaminoethyl ChitosanPoly Polydiisopropylaminoethyl
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Teixeira, Leila S.

; Carvalho, Stephanne Y. B. de

; Santos, Ana Cláudia dos

; Borges, Marcella M. C. Vieira, Sara S. Borges, Keyller B. Guimarães, Luiz Gustavo L.

Journal of the Brazilian Chemical Society

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2024, Volume 35 Nº 9 elocation e-20240048

Resumo: En | Texto: En | PDF: En

A new composite material with magnetic and pH-responsive properties, composed of chitosan/poly(2-diisopropylamino)ethyl methacrylate (Fe3O4/SiO2/CS/PDPA) was developed with the purpose of removing avermectins in aqueous media. The material was characterized by different techniques to evaluate its characteristics. The adsorption process was investigated through the optimization of some parameters, with the most favorable results at pH 8.0, using 20 mg of adsorbent and stirring for 5 min. Under such conditions, the material showed adsorption efficiency of around 80.5, 69.9, and 74.8% for eprinomectin, doramectin and ivermectin, respectively. The adsorption mechanism was investigated using the pseudo-second order kinetic model and the Langmuir-Freundlich dual site isotherm model. Thermodynamic analysis indicated that the adsorption process is exothermic and spontaneous. The material also showed good regenerative capacity, allowing several reuse cycles. The results obtained suggest that the synthesized material has potential application as an adsorbent in the removal of avermectins from aqueous samples. pHresponsive responsive properties chitosan/poly2diisopropylaminoethyl chitosanpoly2diisopropylaminoethyl chitosanpolydiisopropylaminoethyl chitosan/poly 2 diisopropylamino ethyl chitosan poly Fe3O4/SiO2/CS/PDPA Fe3O4SiO2CSPDPA FeOSiOCSPDPA Fe3O4 SiO2 CS PDPA Fe O SiO (Fe3O4/SiO2/CS/PDPA media characteristics parameters 80 8 0 8.0 min conditions 805 80.5 699 69 9 69.9 748 74 74.8 eprinomectin ivermectin respectively pseudosecond pseudo second LangmuirFreundlich Langmuir Freundlich spontaneous capacity cycles samples poly2diisopropylaminoethyl diisopropylaminoethyl chitosanpoly CSPDPA FeO Fe3O 8. 80. 6 69. 7 74. polydiisopropylaminoethyl

https://doi.org/10.21577/0103-5053.20240048

11.

Prospective, randomized, controlled trial assessing the effects of a driving pressure–limiting strategy for patients with acute respiratory distress syndrome due to community-acquired pneumonia (STAMINA trial): protocol and statistical analysis plan Prospective randomized pressurelimiting pressure limiting communityacquired community acquired STAMINA trial)
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Maia, Israel Silva

; Medrado Jr, Fernando Azevedo

; Tramujas, Lucas

; Tomazini, Bruno Martins

; Oliveira, Júlia Souza

; Sady, Erica Regina Ribeiro

; Barbante, Letícia Galvão

; Nicola, Marina Lazzari

; Gurgel, Rodrigo Magalhães

; Damiani, Lucas Petri

; Negrelli, Karina Leal

; Miranda, Tamiris Abait

; Santucci, Eliana

; Valeis, Nanci

; Laranjeira, Ligia Nasi

; Westphal, Glauco Adrieno

; Fernandes, Ruthy Perotto

; Zandonai, Cássio Luis

; Pincelli, Mariangela Pimentel

; Figueiredo, Rodrigo Cruvinel

; Bustamante, Cíntia Loss Sartori

; Norbin, Luiz Fernando

; Boschi, Emerson

; Lessa, Rafael

; Romano, Marcelo Pereira

; Miura, Mieko Cláudia

; Alencar Filho, Meton Soares de

; Dantas, Vicente Cés de Souza

; Barreto, Priscilla Alves

; Hernandes, Mauro Esteves

; Grion, Cintia Magalhães Carvalho

; Laranjeira, Alexandre Sanches

; Mezzaroba, Ana Luiza

; Bahl, Marina

; Starke, Ana Carolina

; Biondi, Rodrigo Santos Dal-Pizzol, Felipe Caser, Eliana Bernadete Thompson, Marlus Muri Padial, Andrea Allegrini Veiga, Viviane Cordeiro Leite, Rodrigo Thot Araújo, Gustavo Guimarães, Mário Martins, Priscilla de Aquino Lacerda, Fábio Holanda Hoffmann Filho, Conrado Roberto Melro, Livia Pacheco, Eduardo Ospina-Táscon, Gustavo Adolfo Ferreira, Juliana Carvalho Freires, Fabricio Jocundo Calado Machado, Flávia Ribeiro Cavalcanti, Alexandre Biasi Zampieri, Fernando Godinho

Critical Care Science

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2024, Volume 36 elocation e20240210en

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Contexto: Em estudos observacionais sobre a síndrome do desconforto respiratório agudo, sugeriu-se que a driving pressure é o principal fator de lesão pulmonar induzida por ventilador e de mortalidade. Não está claro se uma estratégia de limitação da driving pressure pode melhorar os desfechos clínicos. Objetivo: Descrever o protocolo e o plano de análise estatística que serão usados para testar se uma estratégia de limitação da driving pressure envolvendo a titulação da pressão positiva expiratória final de acordo com a melhor complacência respiratória e a redução do volume corrente é superior a uma estratégia padrão envolvendo o uso da tabela de pressão positiva expiratória final baixa do protocolo ARDSNet, em termos de aumento do número de dias sem ventilador em pacientes com síndrome do desconforto respiratório agudo devido à pneumonia adquirida na comunidade. Métodos: O estudo STAMINA (ventilator STrAtegy for coMmunIty acquired pNeumoniA) é randomizado, multicêntrico e aberto e compara uma estratégia de limitação da driving pressure com a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet em pacientes com síndrome do desconforto respiratório agudo moderada a grave devido à pneumonia adquirida na comunidade internados em unidades de terapia intensiva. Esperamos recrutar 500 pacientes de 20 unidades de terapia intensiva brasileiras e duas colombianas. Eles serão randomizados para um grupo da estratégia de limitação da driving pressure ou para um grupo de estratégia padrão usando a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet. No grupo da estratégia de limitação da driving pressure, a pressão positiva expiratória final será titulada de acordo com a melhor complacência do sistema respiratório. Desfechos: O desfecho primário é o número de dias sem ventilador em 28 dias. Os desfechos secundários são a mortalidade hospitalar e na unidade de terapia intensiva e a necessidade de terapias de resgate, como suporte de vida extracorpóreo, manobras de recrutamento e óxido nítrico inalado. Conclusão: O STAMINA foi projetado para fornecer evidências sobre se uma estratégia de limitação da driving pressure é superior à estratégia da tabela de pressão positiva expiratória final baixa do protocolo ARDSnet para aumentar o número de dias sem ventilador em 28 dias em pacientes com síndrome do desconforto respiratório agudo moderada a grave. Aqui, descrevemos a justificativa, o desenho e o status do estudo. Contexto sugeriuse sugeriu clínicos Objetivo ARDSNet Métodos ventilator pNeumoniA randomizado 50 2 colombianas Desfechos resgate extracorpóreo inalado Conclusão Aqui justificativa 5

ABSTRACT Background: Driving pressure has been suggested to be the main driver of ventilator-induced lung injury and mortality in observational studies of acute respiratory distress syndrome. Whether a driving pressure-limiting strategy can improve clinical outcomes is unclear. Objective: To describe the protocol and statistical analysis plan that will be used to test whether a driving pressure-limiting strategy including positive end-expiratory pressure titration according to the best respiratory compliance and reduction in tidal volume is superior to a standard strategy involving the use of the ARDSNet low-positive end-expiratory pressure table in terms of increasing the number of ventilator-free days in patients with acute respiratory distress syndrome due to community-acquired pneumonia. Methods: The ventilator STrAtegy for coMmunIty acquired pNeumoniA (STAMINA) study is a randomized, multicenter, open-label trial that compares a driving pressure-limiting strategy to the ARDSnet low-positive end-expiratory pressure table in patients with moderate-to-severe acute respiratory distress syndrome due to community-acquired pneumonia admitted to intensive care units. We expect to recruit 500 patients from 20 Brazilian and 2 Colombian intensive care units. They will be randomized to a driving pressure-limiting strategy group or to a standard strategy using the ARDSNet low-positive end-expiratory pressure table. In the driving pressure-limiting strategy group, positive end-expiratory pressure will be titrated according to the best respiratory system compliance. Outcomes: The primary outcome is the number of ventilator-free days within 28 days. The secondary outcomes are in-hospital and intensive care unit mortality and the need for rescue therapies such as extracorporeal life support, recruitment maneuvers and inhaled nitric oxide. Conclusion: STAMINA is designed to provide evidence on whether a driving pressure-limiting strategy is superior to the ARDSNet low-positive end-expiratory pressure table strategy for increasing the number of ventilator-free days within 28 days in patients with moderate-to-severe acute respiratory distress syndrome. Here, we describe the rationale, design and status of the trial. Background ventilatorinduced induced pressurelimiting limiting unclear Objective endexpiratory end expiratory lowpositive low ventilatorfree free communityacquired community Methods (STAMINA multicenter openlabel open label moderatetosevere moderate severe units 50 Outcomes inhospital hospital support oxide Conclusion Here rationale 5

https://doi.org/10.62675/2965-2774.20240210-en

12.

Ocular manifestations in patients diagnosed with dengue in a reference hospital in the city of Manaus, Brazil Manaus
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Chaves Filho, Cláudio do Carmo

; Chaves, Cláudia Maria Osório

; de Lacerda, Marcos Vinicius Guimarães

; Ferreira, Luiz Carlos de Lima

Revista Brasileira de Oftalmologia

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2024, Volume 83 elocation e0031

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Determinar a prevalência de alterações oculares em pacientes com diagnóstico de dengue, internados em um centro de referência para doenças infecciosas e parasitárias em Manaus (AM), Brasil. Métodos: Estudo observacional, analítico e prospectivo de série de casos de 33 pacientes admitidos no hospital com exames de patologia clínica positivos durante um período de 90 dias de uma epidemia de dengue em 2011. As investigações incluíram medida da acuidade visual, avaliação macular com tela de Amsler, biomicroscopia de fundo de olho, retinografia e tomografia de coerência ótica. Resultados: A idade média dos pacientes foi de 35,48 anos (idade mínima de 17 anos e máxima de 69 anos). Os principais sintomas relatados foram visão turva, seguida de dor retro-ocular, fotopsia, halos, corpos estranhos, escotoma, visão dupla e moscas volantes. A acuidade visual variou entre 20/20 e 20/40 (mediana 20/30). A avaliação macular com a tela de Amsler foi insatisfatória em três doentes. Os achados retinianos mais comuns foram edema perimacular, edema macular, hemorragia retiniana, vasculite e alterações no epitélio pigmentar da retina. A tomografia de coerência óptica mostrou edema da retina em 16 doentes (51,51%). Conclusões: Em todos os casos, a doença foi autolimitada e resolveu-se espontaneamente sem tratamento. Este estudo confirma, portanto, que as manifestações oculares da dengue são variadas e frequentes. Objetivo AM, AM , (AM) Brasil Métodos observacional 3 9 2011 olho ótica Resultados 3548 35 48 35,4 1 6 anos. . anos) turva retroocular, retroocular retro ocular, ocular retro-ocular fotopsia halos estranhos escotoma volantes 2020 20 20/2 2040 40 20/4 mediana 20/30. 2030 20/30 30 20/30) perimacular retiniana 51,51%. 5151 51,51% 51 (51,51%) Conclusões resolveuse resolveu se tratamento confirma portanto frequentes (AM 201 354 4 35, 202 2 20/ 204 203 20/3 515 51,51 5 (51,51% 51,5 (51,51 51, (51,5 (51, (51 (5 (

ABSTRACT Objective: To determine the prevalence of ocular alterations in patients diagnosed with dengue, admitted to a reference center for infectious and parasitic diseases in Manaus (AM), Brazil. Methods: This was an observational, analytical, and prospective case series study with 33 patients admitted to the hospital with positive clinical pathology tests during a 90-day period of a dengue epidemic in 2011. The investigations included measurement of visual acuity, macular assessment with Amsler grid test, fundus biomicroscopy, retinography and optical coherence tomography. Results: The average age of the patients was 35.48 years (minimum age 17 years and maximum 69 years). The main symptoms reported were blurred vision, followed by retro-ocular pain, photopsia, halos, foreign bodies, scotoma, double vision, and floaters. Visual acuity ranged from 20/20 to 20/40 (median 20/30). Macular assessment with Amsler Grid Test was unsatisfactory in three patients. The most common retinal findings were perimacular edema, macular edema, retinal hemorrhage, vasculitis, and changes in the retinal pigment epithelium. Optical coherence tomography showed retinal edema in 16 patients (51.51%). Conclusions: In all cases, the disease was self-limiting and resolved spontaneously without treatment. Therefore, this study confirms that ocular manifestations in dengue fever are varied and frequent. Objective AM, AM , (AM) Brazil Methods observational analytical 3 90day day 90 2011 test biomicroscopy Results 3548 35 48 35.4 minimum 1 6 years. . years) vision retroocular retro pain photopsia halos bodies scotoma floaters 2020 20 20/2 2040 40 20/4 median 20/30. 2030 20/30 30 20/30) hemorrhage vasculitis epithelium 51.51%. 5151 51.51% 51 (51.51%) Conclusions cases selflimiting self limiting treatment Therefore frequent (AM 9 201 354 4 35. 202 2 20/ 204 203 20/3 515 51.51 5 (51.51% 51.5 (51.51 51. (51.5 (51. (51 (5 (

https://doi.org/10.37039/1982.8551.20240031

13.

Noninvasive assessment of liver fibrosis can predict clinical outcomes at late follow-up after a sustained virological response in HCV patients? followup follow up patients
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Ragazzo, Taisa Grotta

; Zitelli, Patricia Momoyo Yoshimura

; Mazo, Daniel F.

; Oliveira, Claudia P.

; Carrilho, Flait José

; Pessoa, Mário Guimarães

Clinics

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2024, Volume 79 elocation 100381

Resumo: En | Texto: En | PDF: En

Abstract Objectives The primary objective was to evaluate Liver-Related Events (LREs), including hepatic decompensation (ascites, hemorrhagic varices and encephalopathy) and Hepatocellular Carcinoma (HCC), as well as changes in liver stiffness during the follow-up period among patients who achieved a Sustained Virological Response (SVR) after treatment for chronic Hepatitis C Virus (HCV) infection. Methods A total of 218 patients with HCV were treated, and those who achieved an SVR were followed up for 3-years. Transient Elastography (TE) using FibroScan® was performed at various time points: before treatment, at the end of treatment, at 6-months post-treatment, at 1-year post-treatment, at 2-years post-treatment, and at 3-years post-treatment. Results At 6-months post-treatment, a Liver Stiffness Measurement (LSM) cutoff of > 19 KPa was identified, leading to a 14.5-fold increase in the hazard of negative outcomes, including decompensation and/or HCC. The analysis of relative changes in liver stiffness between pre-treatment and 6-months posttreatment revealed that a reduction in LSM of -10 % was associated with a -12 % decrease in the hazard of decompensation and/or HCC, with this trend continuing as the LSM reduction reached -40 %, resulting in a -41 % hazard of decompensation and/or HCC. Conversely, an increase in the relative change during this period, such as an LSM increase of +10 %, led to a + 14 % increase in the hazard of decompensation. In cases where this relative change in LSM was +50 %, the hazard of decompensation increased to +92. Conclusion Transient elastography using FibroScan® can be a good tool for monitoring HCV patients with SVR after treatment to predict LREs in the long term. LiverRelated Related LREs, , (LREs) ascites, ascites (ascites encephalopathy HCC (HCC) followup follow (SVR (HCV infection 21 treated 3years. 3years years 3 years. TE (TE FibroScan points 6months months 6 posttreatment, post post-treatment 1year year 1 2years 2 posttreatment. treatment. (LSM identified 14.5fold 145fold fold 14.5 5 outcomes andor or pretreatment pre 10 -1 12 40 -4 41 Conversely +1 50 +5 92 +92 term (LREs (HCC 5fold 145 14. - 4 9 +9

https://doi.org/10.1016/j.clinsp.2024.100381

14.

ASSOCIATION BETWEEN ANXIETY AND DEPRESSION IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD) DYSFUNCTIONASSOCIATED DYSFUNCTION ASSOCIATED MASLD (MASLD
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BOTACIN, Eloyse Cristina

; DUARTE, Sebastião Mauro Bezerra

; STEFANO, José Tadeu

; BARBOSA, Mary Ellen Dias

; PESSOA, Mario Guimarães

; OLIVEIRA, Cláudia P

Arquivos de Gastroenterologia

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2024, Volume 61 elocation e23128

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Contexto: Este estudo teve como objetivo avaliar a frequência e a intensidade dos sintomas ansiosos e depressivos em pacientes com diagnóstico de doença hepática esteatótica associada à disfunção metabólica [do inglês: Metabolic dysfunction-associated steatotic liver disease (MASLD)]. Métodos: Trata-se de um estudo descritivo e transversal, resultante do acompanhamento de 106 pacientes do Ambulatório de Doença Hepática Esteatótica Associada à Disfunção Metabólica (A2MG700) da Disciplina de Gastroenterologia Clínica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, Brasil, sem história de abuso de álcool, verificada pelo Alcohol Use Disorders Identification Test (AUDIT). Foram avaliados os dados sociodemográficos, Escala hospitalar de ansiedade e depressão [do inglês: Hospital Anxiety and Depression Scale (HADS)], Escala de avaliação de ansiedade de Hamilton [do inglês: Hamilton Anxiety Rating Scale (HAM-A)] e Escala de depressão de Hamilton [do inglês: Hamilton Depression Scale (HAM-D)]. Resultados: Um total 69,8% dos indivíduos eram do sexo feminino com idade média de 61 anos. A maioria dos indivíduos avaliados (71,7%) descobriu a doença por meio de exames de rotina e apresentavam diabetes mellitus tipo 2 (59,4%), dislipidemia (49,1%), hipertensão arterial (68,9%), obesidade (61,3%) e síndrome metabólica [SM (63,2%)]. A análise da escala HADS demonstrou probabilidade de ansiedade em 34% dos participantes e 33% de sintomas depressivos. A escala de intensidade de Hamilton demonstrou que 63,9% dos indivíduos apresentavam ansiedade severa e 54,3% depressão severa. Observamos também relação entre ansiedade, depressão e o sexo feminino, assim como, entre depressão e SM. Conclusão: Nossos achados demonstram a presença de ansiedade e depressão em mais de 1/3 dos indivíduos com MASLD avaliados e a maioria apresenta sintomas graves. O grupo era composto por pacientes idosos e com comorbidades, incluindo SM. Observamos correlação positiva entre ansiedade, depressão e sexo feminino, sendo significativa entre SM e depressão. Contexto inglês dysfunctionassociated dysfunction associated MASLD. . (MASLD)] Métodos Tratase Trata se transversal 10 A2MG700 AMG MG (A2MG700 HCFMUSP, HCFMUSP HC FMUSP , (HC-FMUSP) Brasil álcool AUDIT. AUDIT (AUDIT) sociodemográficos HADS, (HADS)] HAMA HAM (HAM-A) HAMD. HAMD D (HAM-D)] Resultados 698 69 8 69,8 6 anos 71,7% 717 71 7 (71,7% 59,4%, 594 59,4% 59 4 (59,4%) 49,1%, 491 49,1% 49 1 (49,1%) 68,9%, 689 68,9% 68 9 (68,9%) 61,3% 613 3 (61,3% 63,2%. 632 63,2% 63 (63,2%)] 34 33 639 63,9 543 54 54,3 Conclusão 13 1/ graves comorbidades (MASLD) A2MG70 (A2MG70 (HC-FMUSP (AUDIT (HADS) (HAM-A (HAM-D) 69, 71,7 (71,7 59,4 5 (59,4% 49,1 (49,1% 68,9 (68,9% 61,3 (61,3 63,2 (63,2%) 63, 54, (MASLD A2MG7 (A2MG7 (HADS (HAM-D 71, (71, 59, (59,4 49, (49,1 68, (68,9 61, (61, (63,2% A2MG (A2MG (71 (59, (49, (68, (61 (63,2 (7 (59 (49 (68 (6 (63, ( (5 (4 (63

ABSTRACT Background: This study aimed to assess the frequency and intensity of anxious and depressive symptoms in patients diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: This is a descriptive and cross-sectional study, resulting from 106 patients from the Hepatology outpatient clinic at the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), São Paulo, Brazil without a history of alcohol abuse, verified by the alcohol use disorders identification test (AUDIT). These were assessed using the sociodemographic data sheet, Hospital Anxiety and Depression Scale (HADS), Hamilton Anxiety Rating Scale (HAM-A), and Hamilton Depression Scale (HAM-D). Results: A total of 69.8% were women and 30.2% were men, with a mean age of 61 years. The majority (71.7%) discovered MASLD through routine exams, presenting as comorbidities: Type 2 diabetes mellitus (59.4%), Dyslipidemia (49.1%), Arterial hypertension (68.9%), Obesity (61.3%) and Metabolic syndrome [MetS (63.2%)]. The HADS scale indicates 34% probability of anxiety and 33% depressive symptoms. The Hamilton’s scales of intensity indicates 63.9% severe anxiety and 54.3% severe depression. There is also a relationship between anxiety, depression and the female gender, as well as between depression and MetS. Conclusion: The findings point to the presence of anxiety and depression in more than one third of MASLD patients, most with severe symptoms. The group is concentrated in the elderly, with many comorbidities, including MetS. There was a positive correlation between anxiety, depression and being female; also, being significant between MetS and depression. Background dysfunctionassociated dysfunction associated MASLD. . (MASLD) Methods crosssectional cross sectional 10 HCFMUSP, HCFMUSP HC FMUSP , (HC-FMUSP) abuse AUDIT. AUDIT (AUDIT) sheet HADS, (HADS) HAMA, HAMA HAM (HAM-A) HAMD. HAMD D (HAM-D) Results 698 69 8 69.8 302 30 30.2 men 6 years 71.7% 717 71 7 (71.7% exams comorbidities 59.4%, 594 59.4% 59 4 (59.4%) 49.1%, 491 49.1% 49 1 (49.1%) 68.9%, 689 68.9% 68 9 (68.9%) 61.3% 613 3 (61.3% 63.2%. 632 63.2% 63 (63.2%)] 34 33 Hamiltons s 639 63.9 543 54 54.3 gender Conclusion elderly (MASLD (HC-FMUSP (AUDIT (HADS (HAM-A (HAM-D 69. 30. 71.7 (71.7 59.4 5 (59.4% 49.1 (49.1% 68.9 (68.9% 61.3 (61.3 63.2 (63.2%) 63. 54. 71. (71. 59. (59.4 49. (49.1 68. (68.9 61. (61. (63.2% (71 (59. (49. (68. (61 (63.2 (7 (59 (49 (68 (6 (63. ( (5 (4 (63

https://doi.org/10.1590/s0004-2803.24612023-128

15.

A domesticação de um cabelo problema: o corpo negro como um território em disputa no romance-ensaio de Djaimilia Pereira de Almeida problema romanceensaio romance ensaio
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Ploia, Talita Hoelz

; Guimarães, Rafael Eisinger

Alea: Estudos Neolatinos

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Dez 2023, Volume 25 Nº 3 Páginas 291 - 307

Resumo: En Pt Es | Texto: En Pt Es | PDF: En | PDF: Pt | PDF: Es

Abstract This study proposes a reading of the novel-essay Esse cabelo, by Angolan writer Djaimilia Pereira de Almeida. More specifically, we intend to demonstrate that the afro hair of Mila, the character-narrator of the work, can be understood as an arena of a dispute of identity issues that involves continuous tensioning and transit between the fixed poles of the colonizer and the colonized. To this end, some theoretical conceptions concerning blackness and racism proposed by names such as bell hooks (2019), Claudia Rankine (2021), Frantz Fanon (2020), Grada Kilomba (2019), and Ingrid Banks (2000) will be discussed, as well as reflections about the feminine developed by thinkers such as Lucía Guerra (1995), Rita Laura Segato (2014) and Sherry Ortner (1979). novelessay novel essay cabelo Almeida specifically Mila characternarrator character narrator work colonized end 2019, 2019 , (2019) 2021, 2021 (2021) 2020, 2020 (2020) 2000 (2000 discussed 1995, 1995 (1995) 2014 (2014 1979. 1979 . (1979) 201 (2019 202 (2021 (2020 200 (200 199 (1995 (201 197 (1979 20 (202 (20 19 (199 (197 2 (2 1 (19 ( (1

Resumo Este estudo propõe uma leitura do romance-ensaio Esse cabelo, da escritora angolana Djaimilia Pereira de Almeida. Em termos mais específicos, pretende-se demonstrar que o cabelo afro de Mila, personagem narradora da obra, pode ser compreendido como uma arena de disputa de questões identitárias que envolvem um tensionamento e um trânsito contínuos entre os polos fixos do colonizador e do colonizado. Para tanto, serão discutidas algumas concepções teóricas referentes à negritude e ao racismo propostas por nomes como bell hooks (2019), Claudia Rankine (2021), Frantz Fanon (2020), Grada Kilomba (2019) e Ingrid Banks (2000), bem como reflexões acerca do feminino desenvolvidas por pensadoras como Lucía Guerra (1995), Rita Laura Segato (2014) e Sherry Ortner (1979). romanceensaio romance ensaio Almeida específicos pretendese pretende se Mila obra colonizado tanto 2019, 2019 , 2021, 2021 (2021) 2020, 2020 (2020) (2019 2000, 2000 (2000) 1995, 1995 (1995) 2014 (2014 1979. 1979 . (1979) 201 202 (2021 (2020 (201 200 (2000 199 (1995 197 (1979 20 (202 (20 (200 19 (199 (197 2 (2 1 (19 ( (1

Resumen Este estudio propone una lectura de la novela-ensayo Esse cabelo, de la escritora angoleña Djaimilia Pereira de Almeida. En términos más específicos, se pretende demostrar que la cabellera afro de Mila, personaje-narradora de la obra, puede entenderse como una arena de disputa de cuestiones identitarias que implica una tensión y un tránsito continuo entre los polos fijos del colonizador y el colonizado. Para ello, se discutirán algunas concepciones teóricas sobre la negritud y el racismo propuestas por nombres como bell hooks (2019), Claudia Rankine (2021), Frantz Fanon (2020), Grada Kilomba (2019) e Ingrid Banks (2000), así como reflexiones sobre lo femenino desarrolladas por pensadoras como Lucía Guerra (1995), Rita Laura Segato (2014) y Sherry Ortner (1979). novelaensayo novela ensayo cabelo Almeida específicos Mila personajenarradora personaje narradora obra colonizado ello 2019, 2019 , 2021, 2021 (2021) 2020, 2020 (2020) (2019 2000, 2000 (2000) 1995, 1995 (1995) 2014 (2014 1979. 1979 . (1979) 201 202 (2021 (2020 (201 200 (2000 199 (1995 197 (1979 20 (202 (20 (200 19 (199 (197 2 (2 1 (19 ( (1

https://doi.org/10.1590/1517-106x/202325316

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