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Patients with genital ambiguity referred without a sex definition: the relationship between clinical picture and defined sex of rearing definition
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Santos, Henrique C.

; Barros, Beatriz A.

; El-Beck, Mayra S.

; Miranda, Marcio L.

; Guaragna, Mara S.

; Fabbri-Scallet, Helena

; Mazzola, Taís N.

; Vieira, Tarsis P.

; Mello, Maricilda P.

; Marques-de-Faria, Antonia P.

; Maciel-Guerra, Andrea T.

; Guerra-Junior, Gil

Jornal de Pediatria

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Dez 2024, Volume 100 Nº 6 Páginas 609 - 613

Resumo: En | Texto: En | PDF: En

Abstract Objective It was to verify the association between the definition of sex of rearing and, clinical and cytogenetic features among patients with genital ambiguity referred without a sex assignment. Methods The sample consisted of 133 patients with genital ambiguity seen at a single reference service. These patients did not have a defined social sex at the first consultation and their etiological diagnosis was obtained during follow-up. Results A total of 133 cases were included, 74 of which were reared as males and 59 as females. No correlation was found between the year of birth and the year of the first consultation with the definition of sex of rearing. However, the definition of sex of rearing was associated with age at the first consultation, severity of genital ambiguity, presence of palpable gonad(s), presence of uterus on ultrasound, karyotype, and diagnosis. Palpable gonad(s), more virilized genitalia, absence of a uterus on ultrasound, 46, XY karyotype, or a karyotype with sex chromosome abnormalities emerged as strong predictors for defining male sex. All 77 (58 %) patients over 18 years old had a gender identity in accordance with the sex of rearing; though 9 of 77 (12 %) had homo or bisexual orientation, especially girls with Congenital Adrenal Hyperplasia. Conclusions Clinical and cytogenetic data were strongly associated with the definition of the sex of rearing of children with genital ambiguity referred to a DSD center without sex assignment. Management in a specialized center allows the establishment of a gender identity in accordance with the sex of rearing. assignment 13 service followup. followup follow up. up follow-up included 7 5 females However gonads, gonads gonad s , gonad(s) ultrasound genitalia 46 58 (5 % 1 12 (1 orientation Hyperplasia gonad(s 4 (

https://doi.org/10.1016/j.jped.2024.05.001

Evaluation of the level of information of pediatricians about the diagnosis and management of cryptorchidism
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Monte, Larissa de Lima

; Ocáriz, Rodrigo Campos

; Bustorff-Silva, Joaquim Murray

; Pegolo, Patricia Traballi de Carvalho

; Guerra-Junior, Gil

; Miranda, Márcio Lopes

Jornal de Pediatria

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Dez 2024, Volume 100 Nº 6 Páginas 640 - 645

Resumo: En | Texto: En | PDF: En

Abstract Objective Evaluate the level of information of pediatricians about the diagnosis and management of cryptorchidism. Method A cross-sectional observational study was conducted using a form via the "Google Forms" platform. The study population included pediatricians and pediatric residents associated with the Brazilian Society of Pediatrics. Seven hundred twenty-eight responses were recorded and analyzed using IBM SPSS v21. Results 728 valid responses were obtained. Of these answers, only 20.5 % answered that the physical examination was sufficient for the diagnosis, and 79.4 % responded that they requested ultrasound as the best test to aid in diagnosing cryptorchidism. When questioned about the ideal age for referring a patient with cryptorchidism, the survey recorded 56.3 % of the responses defending the correct age as six months old, 30.2 % shortly after birth, and 13.2 % at two years old. Other topics were addressed in the form, such as the frequency of evaluation of testicular position and investigation for DDS, among others. Still, the answers to these questions were compatible with current manuals and guidelines on cryptorchidism. Conclusion It is evident that the understanding of the professionals consulted about the diagnosis and management of cryptorchidism needs to be updated with the current practices adopted and that pediatricians, in general, must maintain periodic programs on this subject. Therefore, this topic should be part of a continuing education program with pediatric surgery. crosssectional cross sectional Google Forms platform Pediatrics twentyeight twenty eight v21 v 72 obtained 205 20 5 20. 794 79 4 79. 563 56 3 56. old 302 30 2 30. birth 132 13 13. DDS others Still general subject Therefore surgery v2 7 1

https://doi.org/10.1016/j.jped.2024.06.002

Brazilian growth charts for Williams–Beuren Syndrome at ages 2 to 18 years WilliamsBeuren Williams Beuren 1
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Strafacci, Amanda de Sousa Lima

; Bertapelli, Fabio

; Kim, Chong Ae

; Rivadeneira, Maria José

; Honjo, Rachel Sayuri

; Kulikowski, Leslie Domenici

; Ferreira, Danilo Moretti

; Batista, Letícia Cassimiro

; Lopes, Vera Lúcia Gil da Silva

; Guerra Junior, Gil

Jornal de Pediatria

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Jun 2024, Volume 100 Nº 3 Páginas 277 - 282

Resumo: En | Texto: En | PDF: En

Abstract Objective: To develop growth charts for weight-for-age, height-for-age, and body mass index (BMI)-for-age for both genders aged 2 to 18 years for Brazilian patients with Williams-Beuren Syndrome (WBS). Methods: This is a multicenter, retrospective, and longitudinal study, data were collected from the medical records of boys and girls with a confirmed diagnosis of WBS in three large university centers in the state of Sao Paulo, Brazil. Growth charts stratified by gender and age in years were developed using LMSchartmaker Pro software. The LMS (Lambda Mu Sigma) method was used to model the charts. The quality of the settings was checked by worm plots. Results: The first Brazilian growth charts for weight-for-age, height-for-age, and BMI-for-age stratified by gender were constructed for WBS patients aged 2 to 18 years. Conclusion: The growth charts developed in this study can help to guide family members and to improve the health care offered by health professionals. Objective weightforage, weightforage weight age, weight-for-age heightforage, heightforage height height-for-age BMIforage BMI 1 WilliamsBeuren Williams Beuren WBS. . (WBS) Methods multicenter retrospective Paulo Brazil software Lambda Sigma plots Results Conclusion professionals (WBS

https://doi.org/10.1016/j.jped.2023.11.009

Insights from a Wolfram syndrome cohort: clinical and molecular findings from a specialized diabetes reference center cohort
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Lopes, Carolina Paniago

; Gonçalves Neto, Gentil Ferreira

; Paulino, Maria Fernanda Vanti Macedo

; Esquiaveto-Aun, Adriana Mangue

; de Mello, Maricilda Palandi

; Pavin, Elizabeth João

; Breder, Ikaro Soares Santos

; Pu, Mariana Zorron Mei Hsia

; de Lemos-Marini, Sofia Helena Valente

; Guerra Junior, Gil

Archives of Endocrinology and Metabolism

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2024, Volume 68 elocation e240091

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: Considering the rarity and clinical and molecular diversity of Wolfram syndrome (WS), the objective of this study was to identify patients with a clinical presentation suggestive of WS following up at a single Brazilian diabetes service and analyze their clinical and molecular characteristics. Subjects and methods: The study included all patients with a clinical presentation of WS following up between 1991 and 2022 with early-onset diabetes mellitus and other WS signs and symptoms. A retrospective analysis was conducted, including patients’ age, sex, consanguinity, age at symptom onset, diagnosis of diabetes mellitus, optic atrophy, diabetes insipidus, neurological and psychiatric disorders, hearing loss, urinary disorders, hypogonadism, and WFS1 molecular analysis. Results: Eight patients were identified, all of whom were diagnosed with diabetes mellitus at an average age of 3.7 years. Optic atrophy, diabetes insipidus, and hearing loss were common, while psychiatric and neurological alterations were observed in some cases. Genetic analysis revealed pathogenic variants in homozygosity or compound heterozygosity. The most frequent variant was p. Val412Serfs29, present in five of the seven families. Conclusions: This study represents the second-largest Brazilian sample of WS and is the first cohort from a single center in Southeast Brazil. The patients had an early, severe, and complete clinical presentation. The genetic variants identified were consistent with previous literature descriptions. The variant p. Val412Serfs29 was particularly common in this cohort, highlighting its relevance in the region. Objective WS, , (WS) characteristics methods 199 202 earlyonset early onset symptoms conducted sex consanguinity atrophy insipidus disorders hypogonadism WFS Results 37 3 7 3. years cases heterozygosity p ValSerfs Val Serfs families Conclusions secondlargest second largest Brazil severe descriptions Val412Serfs2 region (WS 19 20 Val412Serfs 1 2

https://doi.org/10.20945/2359-4292-2024-0091

Anthropometry and physical appearance can be associated with quality of life in Brazilian women with Turner syndrome
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Reis, Carolina Trombeta

; Macedo, Marina Cruvinel

; Morcillo, André Moreno

; Guerra Junior, Gil

; Lemos-Marini, Sofia Helena Valente de

Archives of Endocrinology and Metabolism

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Fev 2023, Volume 67 Nº 1 Páginas 126 - 135

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: This study aimed to analyze if anthropometric factors and physical appearance are associated to QoL in Turner syndrome (TS). Materials and methods: Observational, analytical, and cross-sectional study. The SF-36 was applied along with an additional questionnaire regarding specific characteristics of TS. Results: There were no differences in quality of life (QoL) in TS women regarding median height and appropriate height according to parental target height, however, participants satisfied and who did not desire to change their height had better scores in the mental health and role emotional domains than those not satisfied and desired to change it. When comparing participants who were or were not bothered by physical appearance, the results showed that those not bothered by physical appearance had a better score in the vitality and social function domains. Considering patients who did or did not desire to change physical appearance, those who did not want to change their physical appearance had higher scores in the mental component and in the social function and mental health domains of the SF-36. Conclusion: This study indicated that anthropometric factors and physical appearance may possibly be associated to QoL in TS, and also emphasizes the need to develop and validate an official questionnaire regarding specific TS characteristics in order to assess in more detail how specific characteristics of TS interfere with their QoL. Objective . (TS) methods Observational analytical crosssectional cross sectional SF36 SF 36 SF-3 Results (QoL however it SF36. 36. Conclusion (TS SF3 3 SF-

https://doi.org/10.20945/2359-3997000000535

Clinical and laboratory differences between chromosomal and undefined causes of non-obstructive azoospermia: A retrospective study nonobstructive non obstructive azoospermia
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Riccetto, Luísa

; Vieira, Tarsis Paiva

; Viguetti-Campos, Nilma Lucia

; Mazzola, Tais Nitsch

; Guaragna, Mara Sanches

; Fabbri-Scallet, Helena

; Mello, Maricilda Palandi de

; Marques-de-Faria, Antonia Paula

; Maciel-Guerra, Andrea Trevas

; Guerra Junior, Gil

Sao Paulo Medical Journal

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2023, Volume 141 Nº 4 elocation e2022281

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Knowledge of clinical and laboratory differences between chromosomal and undefined causes aids etiological research on non-obstructive azoospermia. OBJECTIVE: Compare clinical and laboratory differences between men with non-obstructive azoospermia due to chromosomal anomalies versus undefined causes DESIGN AND SETTING: A cross-sectional retrospective study conducted at a public university hospital in Campinas (Brazil) METHODS: All men aged 20–40 years with non-obstructive azoospermia were included in the analysis. RESULTS: The 107 cases included 14 with Klinefelter syndrome (KS) (13%), 1 with mosaic KS, 4 with sex development disorders (2 testicular XX, 1 NR5A1 gene mutation, and 1 mild androgen insensitivity syndrome) (4%), 9 with other non-obstructive azoospermia etiologies (8%), and 79 with undefined causes. The 22 chromosomal anomaly cases (14 KS, 1 mosaic KS, 2 testicular XX, 4 sex chromosome anomalies, and 1 autosomal anomaly) were compared with the 79 undefined cause cases. The KS group had lower average testicular volume, shorter penile length, and lower total testosterone levels but greater height, arm span, serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels, and gynecomastia frequency (absent in the undefined group and affecting more than half of the KS group). Patients with testicular XX DSD had LH, FSH, and penile length data intermediate between the KS and undefined cause groups, testicular volume similar to the KS group, and other data similar to the undefined group. CONCLUSION: Clinical and laboratory data differentiate men with non-obstructive azoospermia and chromosomal anomalies, particularly KS and testicular XX, from those with undefined causes or other chromosomal anomalies. BACKGROUND nonobstructive non obstructive OBJECTIVE SETTING crosssectional cross sectional Brazil (Brazil METHODS 2040 20 40 20–4 analysis RESULTS 10 (KS 13%, 13 13% , (13%) ( NRA NR NR5A mutation 4%, 4% (4%) 8%, 8 8% (8%) 7 (1 height span LH (LH FSH (FSH absent . group) groups CONCLUSION 204 20– (13% (4% (8% (13 (4 (8

https://doi.org/10.1590/1516-3180.2022.0281.r1.30082022

Estimation of body fat in children with intellectual disability: development and cross-validation of a simple anthropometric method
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Bertapelli, Fabio

; Agiovlasitis, Stamatis

; Motl, Robert W.

; Barros-Filho, Marcos M. de

; Guerra-Junior, Gil

Jornal de Pediatria

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Set 2022, Volume 98 Nº 5 Páginas 519 - 525

Resumo: En | Texto: En | PDF: En

Abstract Objective Population-level monitoring of body composition requires accurate, biologically-relevant, yet feasible methods for estimating percent body fat (%BF). The aim of this study was to develop and cross-validate an equation for %BF from Body Mass Index (BMI), age, and sex among children with intellectual disability (ID). This study further aimed to examine the performance of an existing BMI-based equation (Deurenberg equation) for %BF in children with ID. Method Participants were 107 children (63 boys; aged 6-15 years) with ID randomly allocated to development (n= 81) and cross-validation (n= 26) samples. Dual-Energy X-Ray Absorptiometry provided the criterion %BF. Results The model including BMI, age, and sex (0 = male; 1 = female) had a significant goodness-of-fit in determining %BF (p< 0.001; R2= 0.69; SEE =5.68%). The equation was: %BF = - 15.416 + (1.394 × BMI) + (4.538 × age) - (0.262 × age2) + (5.489 × sex). The equation was cross-validated in the separate sample based on (i) strong correlation (r = 0.82; p< 0.001) and non-significant differences between actual and predicted %BF (28.6 ± 9.6% and 30.1 ± 7.1%, respectively); (ii) mean absolute error (MAE) = 4.4%; and (iii) reasonable %BF estimations in Bland-Altman plot (mean: 1.48%; 95% CI: 12.5, -9.6). The Deurenberg equation had a large %BF underestimation (mean: -7.1%; 95% CI: 5.3, -19.5), significant difference between actual and estimated %BF (28.6 ± 9.7% and 21.5 ± 7.0%, respectively; p< 0.001), and MAE = 8.1%. Conclusions The developed equation with BMI, sex, and age provides valid %BF estimates for facilitating population-level body fat screening among children with ID.

https://doi.org/10.1016/j.jped.2022.01.003

Leydig and Sertoli cell function in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion: a case-control study
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Guaragna-Filho, Guilherme

; Calixto, Antônio Ramos

; Astur, Anna Beatriz Lima do Valle

; Paula, Georgette Beatriz de

; Oliveira, Laurione Cândido de

; Morcillo, André Moreno

; Gonçalves, Ezequiel Moreira

; Mello, Maricilda Palandi de

; Maciel-Guerra, Andrea Trevas

; Guerra-Junior, Gil

Sao Paulo Medical Journal

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Fev 2022, Volume 140 Nº 2 Páginas 163 - 170

Resumo: En | Texto: En | PDF: En

Abstract BACKGROUND: Because normal male sexual differentiation is more complex than normal female sexual differentiation, there are more cases of disorders of sex development (DSDs) with 46,XY karyotype that have unclear etiology. However, Leydig and Sertoli cell markers are rarely used in distinguishing such individuals. OBJECTIVES: To evaluate the function of Leydig and Sertoli cells in individuals with genital ambiguity, 46,XY karyotype, palpable gonads and normal testosterone secretion. STUDY DESIGN AND SETTING: Case-control study with 77 patients, including eight with partial androgen insensitivity syndrome, eight with 5α-reductase deficiency type 2 (5ARD2) and 19 with idiopathic 46,XY DSD, and 42 healthy controls, from the Interdisciplinary Study Group for Sex Determination and Differentiation (GIEDDS), at the State University of Campinas (UNICAMP), Campinas, Brazil. METHODS: Baseline levels of gonadotropins, anti-Müllerian hormone (AMH), inhibin B, insulin-like 3 (INSL3), testosterone and dihydrotestosterone in cases, and AMH, inhibin B, and INSL3 levels in controls, were assessed. RESULTS: There was no significant difference in age between cases and controls (P = 0.595). AMH and inhibin B levels were significantly lower in cases than in controls (P = 0.031 and P < 0.001, respectively). INSL3 levels were significantly higher in cases than in controls (P = 0.003). Inhibin B levels were lower in 5ARD2 patients (P = 0.045) and idiopathic patients (P = 0.001), in separate comparisons with the controls. CONCLUSION: According to our findings, we can speculate that inhibin B levels may be used to differentiate among DSD cases.

https://doi.org/10.1590/1516-3180.2021.0042.r1.08062021

Clinical and laboratory differences between chromosomal and undefined causes of non-obstructive azoospermia: A retrospective study nonobstructive non obstructive azoospermia
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Riccetto, Luísa

; Vieira, Tarsis Paiva

; Viguetti-Campos, Nilma Lucia

; Mazzola, Tais Nitsch

; Guaragna, Mara Sanches

; Fabbri-Scallet, Helena

; Mello, Maricilda Palandi de

; Marques-de-Faria, Antonia Paula

; Maciel-Guerra, Andrea Trevas

; Guerra Junior, Gil

Sao Paulo Medical Journal

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2022, Nº ahead

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/1516-3180.2022.0281.r1.30082022

10.

Diretrizes Brasileiras de Hipertensão Arterial – 2020
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Barroso, Weimar Kunz Sebba

; Rodrigues, Cibele Isaac Saad

; Bortolotto, Luiz Aparecido

; Mota-Gomes, Marco Antônio

; Brandão, Andréa Araujo

; Feitosa, Audes Diógenes de Magalhães

; Machado, Carlos Alberto

; Poli-de-Figueiredo, Carlos Eduardo

; Amodeo, Celso

; Mion Júnior, Décio

; Barbosa, Eduardo Costa Duarte

; Nobre, Fernando

; Guimarães, Isabel Cristina Britto

; Vilela-Martin, José Fernando

; Yugar-Toledo, Juan Carlos

; Magalhães, Maria Eliane Campos

; Neves, Mário Fritsch Toros

; Jardim, Paulo César Brandão Veiga

; Miranda, Roberto Dischinger

; Póvoa, Rui Manuel dos Santos

; Fuchs, Sandra C

; Alessi, Alexandre

; Lucena, Alexandre Jorge Gomes de

; Avezum, Alvaro

; Sousa, Ana Luiza Lima

; Pio-Abreu, Andrea

; Sposito, Andrei Carvalho

; Pierin, Angela Maria Geraldo

; Paiva, Annelise Machado Gomes de

; Spinelli, Antonio Carlos de Souza

; Nogueira, Armando da Rocha

; Dinamarco, Nelson

; Eibel, Bruna

; Forjaz, Cláudia Lúcia de Moraes

; Zanini, Claudia Regina de Oliveira

; Souza, Cristiane Bueno de

; Souza, Dilma do Socorro Moraes de

; Nilson, Eduardo Augusto Fernandes

; Costa, Elisa Franco de Assis

; Freitas, Elizabete Viana de

; Duarte, Elizabeth da Rosa

; Muxfeldt, Elizabeth Silaid

; Lima Júnior, Emilton

; Campana, Erika Maria Gonçalves

; Cesarino, Evandro José

; Marques, Fabiana

; Argenta, Fábio

; Consolim-Colombo, Fernanda Marciano

; Baptista, Fernanda Spadotto

; Almeida, Fernando Antonio de

; Borelli, Flávio Antonio de Oliveira

; Fuchs, Flávio Danni

; Plavnik, Frida Liane

; Salles, Gil Fernando

; Feitosa, Gilson Soares

; Silva, Giovanio Vieira da

; Guerra, Grazia Maria

; Moreno Júnior, Heitor

; Finimundi, Helius Carlos

; Back, Isabela de Carlos

; Oliveira Filho, João Bosco de

; Gemelli, João Roberto

; Mill, José Geraldo

; Ribeiro, José Marcio

; Lotaif, Leda A. Daud

; Costa, Lilian Soares da

; Magalhães, Lucélia Batista Neves Cunha

; Drager, Luciano Ferreira

; Martin, Luis Cuadrado

; Scala, Luiz César Nazário

; Almeida, Madson Q.

; Gowdak, Marcia Maria Godoy

; Klein, Marcia Regina Simas Torres

; Malachias, Marcus Vinícius Bolívar

; Kuschnir, Maria Cristina Caetano

; Pinheiro, Maria Eliete

; Borba, Mario Henrique Elesbão de

; Moreira Filho, Osni

; Passarelli Júnior, Oswaldo

; Coelho, Otavio Rizzi

; Vitorino, Priscila Valverde de Oliveira

; Ribeiro Junior, Renault Mattos

; Esporcatte, Roberto

; Franco, Roberto

; Pedrosa, Rodrigo

; Mulinari, Rogerio Andrade

; Paula, Rogério Baumgratz de

; Okawa, Rogério Toshiro Passos

; Rosa, Ronaldo Fernandes

; Amaral, Sandra Lia do

; Ferreira-Filho, Sebastião R.

; Kaiser, Sergio Emanuel

; Jardim, Thiago de Souza Veiga

; Guimarães, Vanildo

; Koch, Vera H.

; Oigman, Wille

; Nadruz, Wilson

Arquivos Brasileiros de Cardiologia

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Mar 2021, Volume 116 Nº 3 Páginas 516 - 658

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.36660/abc.20201238 10948 downloads

11.

COVID-19 information exposure in digital media and implications for employees in the health care sector: findings from an online survey
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Bazán, Paulo Rodrigo

; Azevedo Neto, Raymundo Machado de

; Dias, Julia Abou

; Salvatierra, Vanessa Gil

; Sanches, Liana Guerra

; Lacerda, Shirley Silva

; Amaro Junior, Edson

; Kozasa, Elisa Harumi

; Balardin, Joana Bisol

einstein (São Paulo)

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2020, Volume 18 elocation eAO6127

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Estimar o consumo de informações relacionadas com doença do novo coronavírus e seus efeitos em profissionais do setor da saúde durante a pandemia. Métodos: Um questionário on-line foi distribuído para funcionários de uma instituição de saúde em São Paulo, Brasil, entre 3 e 10 de abril de 2020. Os dados foram analisados com estatísticas descritivas. Resultados: Foram incluídos nas análises 2.646 participantes. A maioria (44,4%) reportou ter acessado uma quantidade excessiva ou próxima de excessiva sobre o novo coronavírus, e 67,6% reportaram ter aumentado seu tempo médio em mídias sociais. Quando perguntados se era fácil determinar o que era informação confiável, 43,2% responderam “às vezes”, comparados com 14,6% que responderam “sempre”. Sobre os possíveis sinais de sobrecarga de informação associada com a pandemia, 31% sempre ou quase todos os dias se sentiram estressados com a quantidade de informações que tinham que acompanhar. Entre os respondentes, 80,0% reportaram sentir pelo menos um sintoma como dor de cabeça, espasmos oculares, inquietação ou dificuldade para dormir. Participantes com um estilo mais negativo de lidar com muitas informações também reportaram maior proporção de sintomas que os participantes com estilo positivo. De forma semelhante, participantes que aumentaram seu acesso a mídias sociais reportaram maior proporção de sintomas do que os que diminuíram seu acesso durante a pandemia. Conclusão: Nossa pesquisa fornece uma descrição de como os indivíduos consomem informações relacionadas com a doença do novo coronavirus durante a pandemia e sugere que a exposição a uma quantidade excessiva de informações e as elevadas demandas podem impor sofrimento psicológico e afetar a saúde mental.

ABSTRACT Objective: To estimate coronavirus disease 2019-related information consumption and related implications for health care professionals (medical and nonmedical personnel) during the pandemic. Methods: A cross-sectional on-line survey was distributed to employees of a major health care institution located in São Paulo, Brazil between April 3 and April 10, 2020. Data were analyzed using descriptive statistics. Results: The sample comprised 2,646 respondents. Most participants (44.4%) reported excessive or almost excessive access to information about the novel coronavirus and 67.6% reported having increased their average time spent on social media. When asked how frequently they consider it was easy to determine the reliability of information, “sometimes” corresponded to 43.2% of the answers in contrast to 14.6% responding “always”. Answers related to potential signs of information overload associated with the pandemic indicated that 31% of respondents felt stressed by the amount of information they had to keep up with almost every day or always. Overall, 80.0% of respondents reported having experienced at least one of the following symptoms: headache, eye twitching, restlessness or sleeping difficulty. The frequency of symptoms was higher among participants with a more negative information processing style regarding when dealing with large volumes of information relative to those with a positive information processing style. Likewise, symptoms were more frequently reported by participants who had increased their social media access relative to those reporting reduced access during the pandemic. Conclusion: Our survey provides a description of how health professionals consume COVID-19 related information during the pandemic, and suggests that excessive information exposure and high processing demands may impose psychological distress and affect mental health.

https://doi.org/10.31744/einstein_journal/2020ao6127 1276 downloads

12.

Influence of physical training on bone mineral density in healthy young adults: a systematic review
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Avila, Josiel Almeida de

; Avila, Rafael Almeida de

; Gonçalves, Ezequiel Moreira

; Guerra Junior, Gil

Revista da Associação Médica Brasileira

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Ago 2019, Volume 65 Nº 8 Páginas 1102 - 1106

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/1806-9282.65.8.1102 1133 downloads

13.

Assessment of bone mineral density in young female handball players
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Krahenbühl, Tathyane

; Borges, Juliano Henrique

; Barros Filho, Antonio de Azevedo

; Guerra-Junior, Gil

; Gonçalves, Ezequiel Moreira

Revista Brasileira de Cineantropometria & Desempenho Humano

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Fev 2018, Volume 20 Nº 1 Páginas 102 - 113

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Otimizar o ganho da massa óssea durante a infância e adolescência pode auxiliar na prevenção de doenças ósseas em idades mais avançadas. Objetivou-se verificar a densidade mineral óssea (DMO) e conteúdo mineral ósseo (CMO) em adolescentes do sexo feminino. Foi realizado um estudo transversal com 68 meninas adolescentes (12 a 17 anos), divididas em dois grupos: jogadoras de handebol (HG: n=29) e grupo controle (CG: n=39). DMO e CMO de corpo inteiro (TB), corpo total menos cabeça (TBLH), coluna lombar (L1-L4), colo do fêmur (FN) e triângulo de Ward’s (WT) e respectivos escore Z foram medidos usando a absorciometria por dupla emissão de raios-x (DXA). Também foi avaliada a maturidade sexual, menarca, PVC e ingestão de cálcio e vitamina D. As jogadoras de handebol mostraram valores de CMO, DMO e respectivos escores Z do corpo inteiro, TBLH, fêmur, quadril e coluna lombar significativamente maiores quando comparados ao grupo controle. Quando ajustados para a massa isenta de gordura o grupo HG apresentou valores maiores para o CMO do fêmur e DMO do fêmur e TBLH; e nos valores de escore Z de todos os sítios ósseos, exceto o quadril, quando comparadas ao CG. Concluímos que as jogadoras de handebol têm valores de massa óssea significativamente maiores comparadas ao grupo de meninas da mesma idade.

Abstract Optimizing bone mass gain during childhood and adolescence may help prevent bone diseases in advanced ages. The aim of this study was to verify the bone mineral density (BMD) and bone mineral content (BMC) in female adolescent’s handball players. This is a cross-sectional study where 68 female adolescents (12–17 years) were allocated into two groups: handball players (n = 29) (HG) and control group (n = 39) (CG). BMC and BMD from total body (TB), total body less head (TBLH), lumbar spine (L1–L4), femoral neck (FN), Ward’s triangle (WT) and respectively Z-scores were measured using dual-energy X-ray absorptiometry (DXA). Sexual maturity, menarche, PHV, time of sun exposure, physical activity level and Calcium and vitamin D intake were assessed. The HG showed significantly higher BMC, BMD as well Z-scores values (p≤0.05) of total body, TBLH, femoral neck, hip and lumbar spine than the CG. When the values were adjusted for lean soft tissue (LST) the HG showed significantly higher BMC of femoral neck (p≤0.05), as well as BMD of TBLH and femoral neck (p≤0.05) and Z-score values all bone sites except hip, than the CG. We conclude that handball players have significantly higher bone mass values compared to group of girls of the same age.

https://doi.org/10.5007/1980-0037.2018v20n1p102 1038 downloads

14.

Neonatal screening: 9% of children with filter paper thyroid-stimulating hormone levels between 5 and 10 µIU/mL have congenital hypothyroidism
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Christensen-Adad, Flávia C.

; Mendes-dos-Santos, Carolina T.

; Goto, Maura M.F.

; Sewaybricker, Letícia E.

; D'Souza-Li, Lília F.R.

; Guerra-Junior, Gil

; Morcillo, André M.

; Lemos-Marini, Sofia Helena V.

Jornal de Pediatria

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Dez 2017, Volume 93 Nº 6 Páginas 649 - 654

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivos: Determinar a prevalência de hipotireoidismo congênito em crianças com TSH em papel filtro (TSH-f) entre 5 e 10 µUI/mL na triagem neonatal. Métodos: Estudo retrospectivo que incluiu crianças triadas de 2003 a 2010, com TSH-f entre 5 e 10 µUI/mL, acompanhadas nos dois primeiros anos de vida quando não houve normalização do TSH sérico. O diagnóstico de hipotireoidismo congênito foi definido como TSH sérico igual ou superior a 10 µUI/mL e início de tratamento com levotiroxina até os dois anos. Resultados: Dos 380.741 nascidos vivos triados, 3.713 (1,04%) apresentaram TSH-f entre 5 e 10 µUI/mL e, desses, 339 (9,13%) tinham hipotireoidismo congênito. Desses, 76,11% dos casos foram diagnosticados nos primeiros três meses de vida e 7,96% entre um e dois anos. Conclusão: O estudo mostra que 9,13% das crianças com TSH-f entre 5 e 10 µUI/mL desenvolveram hipotireoidismo e que em cerca de um quarto delas o diagnóstico só se confirmou após o terceiro mês de vida. Com base nesses achados, sugere-se, para descartar o hipotireoidismo congênito, o uso do ponto de corte de TSH-f de 5 µUI/mL e o acompanhamento em longo prazo dos lactentes cujo TSH sérico não tenha se normalizado.

Abstract Objectives: To determine the prevalence of congenital hypothyroidism in children with filter-paper blood-spot TSH (b-TSH) between 5 and 10 µIU/mL in the neonatal screening. Methods: This was a retrospective study including children screened from 2003 to 2010, with b-TSH levels between 5 and 10 µIU/mL, who were followed-up during the first two years of life when there was no serum TSH normalization. The diagnosis of congenital hypothyroidism was defined as serum TSH ≥10 µIU/mL and start of levothyroxine treatment up to 2 years of age. Results: Of the 380,741 live births, 3713 (1.04%) had filter paper TSH levels between 5 and 10 µIU/mL and, of these, 339 (9.13%) had congenital hypothyroidism. Of these, 76.11% of the cases were diagnosed in the first three months of life and 7.96% between 1 and 2 years of age. Conclusion: The study showed that 9.13% of the children with b-TSH levels between 5 and 10 µIU/mL developed hypothyroidism and that in approximately one-quarter of them, the diagnosis was confirmed only after the third month of life. Based on these findings, the authors suggest the use of a 5 µIU/mL cutoff for b-TSH levels and long-term follow-up of infants whose serum TSH has not normalized to rule out congenital hypothyroidism.

https://doi.org/10.1016/j.jped.2017.05.003 10870 downloads

15.

Comparação do estado nutricional de meninas de acordo com diferentes referências para índice de massa corporal
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Roman, Everton Paulo

; Ribeiro, Roberto Regis

; Guerra-Junior, Gil

; Barros-Filho, Antonio de Azevedo

Revista Brasileira de Saúde Materno Infantil

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Mar 2015, Volume 15 Nº 1 Páginas 121 - 129

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Objetivos: comparar o estado nutricional de meninas de nove a 17 anos na cidade de Cascavel (PR) segundo três referências para índice de massa corporal (IMC). Métodos: estudo transversal com 2759 meninas. Verificou-se o peso e a estatura obtendo-se o IMC além da avaliação da maturidade sexual e do nível socioeconômico. O estado nutricional foi classificado pelos pontos de corte do IMC propostos por Conde e Monteiro, WHO, e CDC. Resultados: as frequências dos estados nutricionais não diferiram significativamente na mesma referência para IMC por faixa etária, por nível socioeconômico e por tipo de escola. Por nível de maturidade sexual, apenas a referência da WHO apresentou valores de obesidade e sobrepeso maiores para o estadio de mamas grau 5. No entanto, quando comparadas as três referências entre si, o CDC apresentou frequências significativamente menores de sobrepeso e obesidade por faixa etária, por nível de maturidade sexual, por nível socioeconômico e por tipo de escola. Apesar das três referências apresentarem concordância entre si, esta foi maior entre os de Conde e Monteiro, e da WHO. Conclusões: a referência do CDC identificou menor percentual de meninas com sobrepeso e obesidade. As referências propostas por Conde e Monteiro e WHO apresentaram resultados semelhantes.

Objectives: to compare the nutritional status of girls aged between nine and seventeen years in the city of Cascavel (in the Brazilian State of Paraná) according to three body mass index (BMI) references. Methods: a cross-sectional study was conducted with 2759 girls. Weight and height were measured to obtain the BMI and the sexual maturity and socioeconomic status of the girls evaluated. Nutritional status was classified using the BMI cut-off points proposed by Conde & Monteiro, the WHO, and the CDC. Results: the frequencies for different nutritional states did not differ significantly when the same BMI reference was used according to age, socioeconomic status or type of school attended. In terms of sexual maturity, only the WHO reference WHO produced higher levels of obesity and overweight for girls with Stage 5 breasts. However, when the three references were compared with one another, the CDC produced significantly lower frequencies for overweight and obesity by age group, level of sexual maturity, socioeconomic status and type of school. All three references were in agreement, this was greater between Conde & Monteiro, and the WHO. Conclusions: the CDC reference identified a smaller percentage of overweight and obese girls. The references proposed by Conde & Monteiro and the WHO produced similar results.

https://doi.org/10.1590/S1519-38292015000100010 2411 downloads

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