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; Cavalcanti, Alexandre Biasi Gama, Ana Maria Casati Nogueira da Rocha, Angelo Roncalli Miranda Oliveira, Antonio Gonçalves de Serpa Neto, Ary Farias, Augusto Manoel de Carvalho Orlando, Bianca Rodrigues Esteves, Bruno da Costa Mazza, Bruno Franco Silveira, Camila de Freitas Martins Soares Carvalho, Carlos Roberto Ribeiro de Toufen Junior, Carlos Barbas, Carmen Silvia Valente Teixeira, Cassiano Silveira, Débora Dutra da Medeiros, Denise Machado Parolo, Edino Costa, Eduardo Leite Vieira Caser, Eliana Bernadete Oliveira, Ellen Pierre de Banholzer, Eric Grieger Carvalho, Erich Vidal Amorim, Fabio Ferreira Saddy, Felipe Gonçalves, Fernanda Alves Ferreira Galas, Filomena Regina Barbosa Gomes Zanatta, Giovanna Carolina Gardini Silva, Gisele Sampaio Westphal, Glauco Adrieno Matos, Gustavo Faissol Janot de Souza, João Claudio Emmerich de Silva Junior, João Manoel Valiatti, Jorge Luis dos Santos Nascimento Junior, José Ribamar do Rocco, Jose Rodolfo Hajjar, Ludhmila Abrahão Forgiarini Junior, Luiz Alberto Malbuisson, Luiz Marcelo Sá Holanda, Marcelo Alcantara Amato, Marcelo Britto Passos Park, Marcelo Oliveira, Marco Antonio da Rosa e Reis, Marco Antonio Soares Tavares, Marcos Soares Souza, Mario Henrique Dutra de Damasceno, Marta Cristina Pauleti Lira-Batista, Marta Maria da Silva Pattacini, Max Morais Assunção, Murillo Santucci Cesar de Oliveira, Neymar Elias de Franzosi, Oellen Stuani Rocco, Patricia Rieken Macedo Caruso, Pedro Silva, Pedro Leme Mendes, Pedro Vitale Duarte, Pericles Almeida Delfino Santa Neto, Renato Fabio Alberto Della Rodrigues, Ricardo Goulart Cordioli, Ricardo Luiz Palazzo, Roberta Fittipaldi Goldwasser, Rosane Pinheiro, Sabrina dos Santos Justino, Sandra Regina Nemer, Sergio Nogueira Oliveira, Vanessa Martins de Silva, Vinicius Zacarias Maldaner da Nedel, Wagner Luis Bellissimo-Rodrigues, Wanessa Teixeira Oliveira Filho, Wilson de

Critical Care Science

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2025, Volume 37 elocation e20250242en

Resumo: En | Texto: En | PDF: En

ABSTRACT Mechanical ventilation can be a life-saving intervention, but its implementation requires a multidisciplinary approach, with an understanding of its indications and contraindications due to the potential for complications. The management of mechanical ventilation should be part of the curricula during clinical training; however, trainees and practicing professionals frequently report low confidence in managing mechanical ventilation, often seeking additional sources of knowledge. Review articles, consensus statements and clinical practice guidelines have become important sources of guidance in mechanical ventilation, and although clinical practice guidelines offer rigorously developed recommendations, they take a long time to develop and can address only a limited number of clinical questions. The Associação de Medicina Intensiva Brasileira and the Sociedade Brasileira de Pneumologia e Tisiologia sponsored the development of a joint statement addressing all aspects of mechanical ventilation, which was divided into 38 topics. Seventy-five experts from all regions of Brazil worked in pairs to perform scoping reviews, searching for publications on their specific topic of mechanical ventilation in the last 20 years in the highest impact factor journals in the areas of intensive care, pulmonology, and anesthesiology. Each pair produced suggestions and considerations on their topics, which were presented to the entire group in a plenary session for modification when necessary and approval. The result was a comprehensive document encompassing all aspects of mechanical ventilation to provide guidance at the bedside. In this article, we report the methodology used to produce the document and highlight the most important suggestions and considerations of the document, which has been made available to the public in Portuguese.

https://doi.org/10.62675/2965-2774.20250242-en

Prevalence risk of sarcopenia in older Brazilian adults during the pandemic: A cross-sectional analysis of the Remobilize Study pandemic crosssectional cross sectional
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Batista, Patricia Parreira

; Perracini, Monica Rodrigues

; Amorim, Juleimar Soares Coelho de

; Lima, Maria do Carmo Correia de

; Lima, Camila Astolphi

; Pereira, Daniele Sirineu

; Dantas, Renata Gonçalves

; Fittipaldi, Etiene Oliveira da Silva

; Santos, Aurélio Dias

; Campos, Hércules Lázaro Morais

; Pereira, Leani Souza Máximo

Sao Paulo Medical Journal

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2023, Volume 141 Nº 4 elocation e2022159

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Social distancing has led to lifestyle changes among older adults during the coronavirus disease 2019 (COVID-19) pandemic. OBJECTIVES: This study aimed to estimate the prevalence risk of sarcopenia (RS) and investigate its associated factors during the COVID-19 pandemic in older Brazilian adults. DESIGN AND SETTING: Cross-sectional observational analysis of baseline data as part of the Remobilize Study. METHODS: Participants in the study were older adults (≥ 60 years), excluding those who were bedridden or institutionalized. The data collected consisted of answers about the RS (SARC-F), functional status, walking, sedentary behavior (SB), pain, comorbidity, and life space mobility. RESULTS: A total of 1,482 older adults (70 ± 8.14 years, 74% women) participated in the study, and an RS prevalence of 17.1% was found. (95% confidence interval [CI] 15.25–19.15%). The adjusted multivariate model showed a significant association between RS and functional limitation (odds ratio [OR]: 19.05; CI 13.00–28.32), comorbidity (OR: 5.11; CI 3.44–7.81), pain (OR: 4.56; CI 3.33–6.28), total walking (OR: 0.99; CI 0.99–1.00), SB of 8–10 hours (OR: 1.85; CI 1.15–2.93), and SB of > 10 hours (OR: 3.93; CI 2.48–6.22). RS was associated with mobility during the pandemic (OR: 0.97; CI 0.96–0.98). P < 0.05. CONCLUSIONS: During the pandemic, the prevalence of RS in older Brazilians was estimated at 17.1%. Moderate to severe functional limitation, comorbidities, presence of pain, walking, longer SB period, and reduced life space mobility significantly contributed to RS in older adults during the pandemic. BACKGROUND 201 COVID19 COVID 19 (COVID-19 OBJECTIVES (RS COVID-1 SETTING Crosssectional Cross sectional Study METHODS ≥ ( 6 years , years) institutionalized SARCF, SARCF SARC F (SARC-F) status SB, (SB) RESULTS 1482 1 482 1,48 70 (7 814 8 14 8.1 74 women 171 17 17.1 found 95% 95 (95 [CI 15.25–19.15%. 15251915 15.25–19.15% . 15 25 15.25–19.15%) odds OR [OR] 19.05 1905 05 13.00–28.32, 13002832 13.00–28.32 13 00 28 32 13.00–28.32) (OR 5.11 511 5 11 3.44–7.81, 344781 3.44–7.81 3 44 7 81 3.44–7.81) 4.56 456 4 56 3.33–6.28, 333628 3.33–6.28 33 3.33–6.28) 0.99 099 0 99 0.99–1.00, 099100 0.99–1.00 0.99–1.00) 810 8–1 1.85 185 85 1.15–2.93, 115293 1.15–2.93 2 93 1.15–2.93) 3.93 393 2.48–6.22. 248622 2.48–6.22 48 22 2.48–6.22) 0.97 097 97 0.96–0.98. 096098 0.96–0.98 96 98 0.96–0.98) 005 0.05 CONCLUSIONS comorbidities period 20 COVID1 (COVID-1 COVID- (SARC-F (SB 148 1,4 8. 17. 9 (9 1525191 15.25–19.15 [OR 19.0 190 1300283 13.00–28.3 5.1 51 34478 3.44–7.8 4.5 45 33362 3.33–6.2 0.9 09 09910 0.99–1.0 8– 1.8 18 11529 1.15–2.9 3.9 39 24862 2.48–6.2 09609 0.96–0.9 0.0 (COVID- 1, 152519 15.25–19.1 19. 130028 13.00–28. 5. 3447 3.44–7. 4. 3336 3.33–6. 0. 0991 0.99–1. 1. 1152 1.15–2. 3. 2486 2.48–6. 0960 0.96–0. (COVID 15251 15.25–19. 13002 13.00–28 344 3.44–7 333 3.33–6 0.99–1 115 1.15–2 248 2.48–6 096 0.96–0 1525 15.25–19 1300 13.00–2 34 3.44– 3.33– 0.99– 1.15– 24 2.48– 0.96– 152 15.25–1 130 13.00– 3.44 3.33 1.15 2.48 0.96 15.25– 13.00 3.4 3.3 1.1 2.4 15.25 13.0 2. 15.2 13. 15.

https://doi.org/10.1590/1516-3180.2022.0159.r1.19082022

Braden scale has low reliability in different patients under care in intensive care unit
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Veiga, Thalita Pereira

; Rêgo, Adriana Sousa

; Montenegro, Widlani Sousa

; Ferreira, Patrícia Rodrigues

; Rocha, Daniel Santos

; Felipe, Ilana Mírian Almeida

; Santos-de-Araújo, Aldair Darlan

; Mendes, Renata Gonçalves

; Tavarez, Rudys Rodolfo de Jesus

; Bassi-Dibai, Daniela

Revista da Associação Médica Brasileira

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Set 2022, Volume 68 Nº 9 Páginas 1221 - 1227

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: The aim of this study was to assess the inter-reliability of the Braden scale and its subscales for different patients assisted in the intensive care unit. We hypothesized that the Braden scale has low reliability in different populations. METHODS: This reliability study involved the Braden scale in intensive care unit of a hospital. A total of 200 patients were admitted to the intensive care unit in four different groups: neurological patients, sepsis, elderly, and adults affected by trauma. The Braden scale is a tool composed of six subscales for patient assessment: sensory perception, humidity, activity, mobility, nutrition, and friction. The total score was also calculated. The Braden scale was applied by two different nurses with an interval of 20–30 min between applications. RESULTS: For all populations, kappa values considered unsuitable were observed for most categories of the Braden scale, ranging from 0.06–0.25. Only for the total Braden scale score was moderate reliability identified in all groups evaluated, with intraclass correlation coefficient values ranging from 0.48–0.75. CONCLUSIONS: Braden scale is not a reliable tool to be used in the intensive care unit, and we do not recommend the use of this scale to assess the risk of developing pressure injury.

https://doi.org/10.1590/1806-9282.20220249

Does religiosity impact binge drinking among early adolescents? A cross-sectional study in a city in Southeastern Brazil
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Guimarães, Mariana Oliveira

; Guimarães, Gilberto de Lima

; Silva, Jessica Walewska Rodrigues da

; Souza, Kátia Kely Bragança de

; Vieira-Andrade, Raquel Gonçalves

; Ferreira, Raquel Conceição

; Zarzar, Patrícia Maria Pereira de Araújo

Ciência & Saúde Coletiva

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Set 2022, Volume 27 Nº 9 Páginas 3669 - 3678

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O objetivo do estudo foi avaliar a associação entre religiosidade e binge drinking no início da adolescência. Um estudo transversal realizado com adolescentes de 10 a 13 anos de Belo Horizonte, Brasil. Foi realizada uma amostragem aleatória estratificada considerando distrito administrativo e ano escolar. Os adolescentes preencheram um formulário com o AUDIT C, perguntas sobre religiosidade e perguntas sobre binge drinking pelos pais e melhor amigo. Um formulário sobre questões socioeconômicas foi respondido pelos responsáveis. Foi realizada análise descritiva, regressão logística univariada e multivariada. Participaram do estudo 650 adolescentes. A frequência de binge drinking foi de 13,7%. No modelo ajustado, a religiosidade não esteve associada ao binge drinking. As covariáveis associadas foram idade de 12-13 anos (OR: 1,94 IC95%: 1,06-3,56; p=0,030), binge drinking pela mãe (OR: 3,12; IC95%: 1,76-5,52; p<0,001) binge drinking pelo melhor amigo (OR: 6,01; IC95%: 3,40-10,62; p<0,001) e família não nuclear (OR: 1,80; IC95%: 1,01-3,23; p=0,045). Os achados revelaram que apesar dos adolescentes afirmarem serem religiosos, para o binge drinking, os principais fatores que influenciaram essa decisão foi o binge drinking pelo melhor amigo, mãe e família não nuclear.

Abstract This study evaluated the association between religiosity and binge drinking in early adolescence. A cross-sectional study was conducted with adolescents aged 10-13 from Belo Horizonte, Brazil. Stratified random sampling was performed considering the administrative district and school year. Adolescents filled an AUDIT-C form, containing questions about religiosity and binge drinking by parents and their best friends. Adolescents’ caregivers answered a form regarding socioeconomic issues. Descriptive analysis, univariate, and multivariate logistic regression were performed. A total of 650 adolescents participated in the study. The frequency of binge drinking was 13.7%. In the adjusted model, religiosity was not associated with binge drinking. The covariates associated were the age of 12-13 years (OR: 1.94; CI95%: 1.06-3.56; p=0.030), maternal binge drinking (OR: 3.12; CI95%: 1.76-5.52; p<0.001) best friend binge drinking (OR: 6.01; CI95%: 3.40-10.62; p<0.001) and nonnuclear family (OR: 1.80; CI95%: 1.01-3.23; p=0.045). The findings revealed that, for binge drinking, the main factors that influenced this decision were the best friend and maternal binge drinking and family structure, although the adolescents claimed to be religious.

https://doi.org/10.1590/1413-81232022279.03162022

Does religiosity impact binge drinking among early adolescents? A cross-sectional study in a city in Southeastern Brazil
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Guimarães, Mariana Oliveira

; Guimarães, Gilberto de Lima

; Silva, Jessica Walewska Rodrigues da

; Souza, Kátia Kely Bragança de

; Vieira-Andrade, Raquel Gonçalves

; Ferreira, Raquel Conceição

; Zarzar, Patrícia Maria Pereira de Araújo

Ciência & Saúde Coletiva

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Set 2022, Volume 27 Nº 9 Páginas 3669 - 3678

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

https://doi.org/10.1590/1413-81232022279.03162022

Dysregulation in erythrocyte dynamics caused by SARS-CoV-2 infection: possible role in shuffling the homeostatic puzzle during COVID-19
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Mendonça, Michelle Mendanha

; da Cruz, Kellen Rosa

; Pinheiro, Denise da Silva

; Moraes, Gean Carlos Alves

; Ferreira, Patricia Maria

; Ferreira-Neto, Marcos Luiz

; da Silva, Eduardo Sérgio

; Gonçalves, Reggiani Vilela

; Pedrino, Gustavo Rodrigues

; Fajemiroye, James O. Xavier, Carlos Henrique

Hematology, Transfusion and Cell Therapy

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Abr 2022, Volume 44 Nº 2 Páginas 235 - 245

Resumo: En | Texto: En | PDF: En

Abstract Introduction The evolving COVID-19 pandemic became a hallmark in human history, not only by changing lifestyles, but also by enriching scientific knowledge on viral infection and its consequences. Objective Although the management of cardiorespiratory changes is pivotal to a favorable prognosis during severe clinical findings, dysregulation of other systems caused by SARS-CoV-2 infection may imbalance erythrocyte dynamics, such as a bidirectional positive feedback loop pathophysiology. Method and Results Recent evidence shows that SARS-CoV-2 is capable of affecting the genetics and dynamics of erythrocytes and this coexists with a non-homeostatic function of cardiovascular, respiratory and renal systems during COVID-19. In hypothesis, SARS-CoV-2-induced systematical alterations of erythrocytes dynamics would constitute a setpoint for COVID-19-related multiple organ failure syndrome and death. Conclusion The present review covers the most frequent erythrocyte-related non-homeostatic findings during COVID-19 capable of providing mechanistic clues of SARS-CoV-2-induced infection and inspiring therapeutic-oriented scientific evidence.

https://doi.org/10.1016/j.htct.2022.01.005

Prevalence risk of sarcopenia in older Brazilian adults during the pandemic: A cross-sectional analysis of the Remobilize Study
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Batista, Patricia Parreira

; Perracini, Monica Rodrigues

; Amorim, Juleimar Soares Coelho de

; Lima, Maria do Carmo Correia de

; Lima, Camila Astolphi

; Pereira, Daniele Sirineu

; Dantas, Renata Gonçalves

; Fittipaldi, Etiene Oliveira da Silva

; Santos, Aurélio Dias

; Campos, Hércules Lázaro Morais

; Pereira, Leani Souza Máximo

Sao Paulo Medical Journal

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2022, Nº ahead

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1590/1516-3180.2022.0159.r1.19082022

The health facility as a risk factor for multidrug-resistant gram-negative bacteria in critically ill patients with COVID-19
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de Macedo, Viviane

; dos Santos, Gabriela de Souza

; da Silva, Rodolff Nunes

; Couto, Caio Nogara de Menezes

; Bastos, Camila

; Viecelli, Eloize

; Mateus, Marina do Nascimento Graf, Maria Esther Gonçalves, Raquel Bernardelli da Silva, Márcia Aparecida Bernardini, Patricia Dal Bem Grando, Roberta Serra Pereira Boaventura, Viviane Pavanelo Pereira, Helki Simone Rodrigues Levin, Anna S.

Clinics

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2022, Volume 77 elocation 100130

Resumo: En | Texto: En | PDF: En

Abstract Background The relationship between Multidrug Resistant-Gram Negative Bacteria (MDR-GNB) infection and colonization in critically ill COVID-19 patients has been observed, however, it is still poorly understood. This study evaluated the risk factors for acquiring MDR-GNB in patients with severe COVID-19 in Intensive Care Units (ICU). Methods This is a nested case-control study in a cohort of 400 adult patients (≥ 18 years old) with COVID-19, hospitalized in the ICU of 4 hospitals in the city of Curitiba, Brazil. Cases were critical COVID-19 patients with one or more MDR GNB from any surveillance and/or clinical cultures were taken during their ICU stay. Controls were patients from the same units with negative cultures for MDR-GNB. Bivariate and multivariate analyses were done. Results Sixty-seven cases and 143 controls were included. Independent risk factors for MDR bacteria were: male gender (OR = 2.6; 95% CI 1.28‒5.33; p = 0.008); the hospital of admission (OR = 3.24; 95% CI 1.39‒7.57; p = 0.006); mechanical ventilation (OR = 25.7; 95% CI 7.26‒91; p < 0.0001); and desaturation on admission (OR = 2.6; 95% CI 1.27‒5.74; p = 0.009). Conclusions Male gender, desaturation, mechanical ventilation, and the hospital of admission were the independent factors associated with MDR-GNB in patients in the ICU with COVID-19. The only modifiable factor was the hospital of admission, where a newly opened hospital posed a higher risk. Therefore, coordinated actions toward a better quality of care for critically ill COVID-19 patients are essential.

https://doi.org/10.1016/j.clinsp.2022.100130

Solar collector for soil disinfestation to produce Meloidogyne enterolobii free tomato seedlings in semiarid conditions
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Silva, Aline Mayara Gonçalves Barros

; Moura, Maria Andreia Rodrigues de

; Castro, José Mauro da Cunha

; Cabral, Patrícia Gonçalves Castro

; Ishikawa, Francine Hiromi

; Capucho, Alexandre Sandri

Ciência Rural

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2022, Volume 52 Nº 12 elocation e20200756

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO: Neste estudo validamos um coletor solar para desinfestar solo com Meloidogyne enterolobii para a produção de mudas de tomateiro em condições semiáridas. Um experimento no delineamento em blocos casualizados foi conduzido com seis tempos de exposição de solo peneirado em um coletor solar de tubos de zinco. Estes consistiram de 0 (controle), 6, 12, 24, 30 e 36h de exposição, com cinco repetições cada. Após 12h de exposição do solo ao calor no coletor solar, nenhuma galha foi observada em raízes de tomateiro, assim como ovos ou juvenis de segundo estágio de M. enterolobii não foram observados no solo. Dessa maneira, o uso do coletor solar foi eficiente na desinfecção de solo infestado por M. enterolobii visando a produção de mudas de tomateiro em condições semiáridas.

ABSTRACT: In this study, we validated a solar collector for disinfest soil infested by Meloidogyne enterolobii for tomato seedlings production in semiarid conditions. An experiment using a randomized block design was conducted with six exposure times of the sieved substrate in the solar collector of zinc tubes. The treatments consisted of 0 (control), 6, 12, 24, 30 and 36 hours of exposure, with five replicates. After 12 hours of soil exposure in the solar collector, no galls were observed in the tomato roots, neither were eggs and second stage juveniles of M. enterolobii were observed in the soil. Based in the results obtained in this study, the solar collector was efficient in the disinfest of soil infested by M. enterolobii aiming production of tomato seedlings in semiarid conditions.

https://doi.org/10.1590/0103-8478cr20200756

10.

A indústria farmacêutica interfere na sustentabilidade do sistema de saúde pública no Brasil? Uma reflexão sobre a pressão por incorporação de medicamentos
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Tamachiro, Susanna Tawata

; Gonçalves, Fabio Augusto Rodrigues

; Simone, Adriane Lopes Medeiros

; Aguiar, Patricia Melo

Cadernos de Saúde Pública

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2022, Volume 38 Nº 7 elocation e00233321

Resumo: Pt En Es | Texto: Pt En Es | PDF: Pt | PDF: En | PDF: Es

O objetivo foi analisar a contribuição da indústria farmacêutica na sustentabilidade do Sistema Único de Saúde (SUS), a partir da pressão pela incorporação de medicamentos. Para tanto, foi realizado estudo descritivo das solicitações de incorporação de medicamentos enviadas à Comissão Nacional de Incorporação de Tecnologias no SUS (CONITEC) entre 2012 e 2020. Foram analisadas características como a indicação da tecnologia, avaliação econômica, componente de financiamento, consulta pública e decisão da CONITEC. Os resultados foram comparados segundo o tipo de demandante por teste estatístico. Foram analisadas 514 solicitações, sendo 438 referentes à incorporação. A indústria farmacêutica foi responsável por 37% das solicitações e 33,5% das incorporações. Foram observadas diferenças entre os demandantes quanto ao tipo de avaliação econômica e ao valor de razão custo-utilidade incremental, com metade das demandas da indústria acima do limiar de 3 PIB per capita/QALY. A indústria farmacêutica obteve mais contribuições nas consultas públicas de suas solicitações e apresentou concentração das solicitações em agentes antineoplásicos e imunomoduladores e em anti-infecciosos, sobretudo, para hepatite C e HIV. Também notou-se menor quantidade de demandas da indústria farmacêutica nos Componentes Básico e Estratégico da Assistência Farmacêutica. Os achados apontam o tensionamento entre a expressiva participação da indústria como solicitante, alta mobilização em consultas públicas e ênfase em medicamentos do Componente Especializado e a resistência da CONITEC a essa pressão, com tendência de maior recusa e maior participação de outros solicitantes nos pedidos de ampliação de uso, exclusão e incorporação de medicamentos menos requisitados pela indústria farmacêutica.

The objective is to analyze the contribution of the pharmaceutical industry to the sustainability of the Brazilian Unified National Health System (SUS), based on the pressure for the incorporation of medicines. For this purpose, a descriptive study was conducted on requests for the incorporation of medicines sent to Commission for Incorporation of Technologies in the SUS (CONITEC) from 2012 to 2020. Characteristics such as technology indication, economic evaluation, financing component, public consultation, and CONITEC decision were analyzed. The results were compared according to the type of solicitor using statistical tests. 514 requests were analyzed, of which 438 related to incorporation. The pharmaceutical industry accounted for 37% of the requests and 33.5% of the incorporations. Differences were observed between the solicitors regarding the type of economic evaluation and incremental cost-utility ratio value, with half of the industry’s demands above the threshold of 3 PIB per capita/QALY. The pharmaceutical industry obtained more contributions in public consultations of its requests and presented concentration of requests for antineoplastic and immunomodulatory agents and for anti-infectious, especially for hepatitis C and HIV. There was also a lower number of demands from the pharmaceutical industry in the Basic and Strategic Components of Pharmaceutical Assistance. Our findings point to the tension between the significant participation of the industry as an applicant, the high mobilization of public consultations, the emphasis on Specialized Component drugs, and CONITEC’s resistance to this pressure, with a tendency of greater refusal and greater participation of other solicitors in requests for expansion of use, exclusion, and incorporation of drugs that are less requested by the pharmaceutical industry.

El objetivo fue analizar la contribución de la industria farmacéutica a la sostenibilidad del Sistema Único de Salud (SUS), con base en la presión por la incorporación de medicamentos. Para ello, se realizó un estudio descriptivo de las solicitudes de incorporación de medicamentos enviadas a Comisión de Incorporación de Tecnologías en el SUS (CONITEC) entre el 2012 y el 2020. Se analizaron características como la indicación de tecnología, evaluación económica, componente de financiación, consulta pública y decisión de la CONITEC. Los resultados se compararon según el tipo de demandante por prueba estadística. Se analizaron 514 solicitudes, de las cuales 438 se refieren a la incorporación. La industria farmacéutica fue responsable del 37% de las solicitudes y del 33,5% de las incorporaciones. Se observaron diferencias entre los demandantes en cuanto al tipo de evaluación económica y al valor de la relación costo-utilidad incremental, con la mitad de las demandas de la industria por encima del umbral de 3 PIB per cápita/QALY. La industria farmacéutica obtuvo más contribuciones en las consultas públicas de sus solicitudes y presentó una concentración de solicitudes en agentes antineoplásicos e inmunomoduladores y en antiinfecciosos, especialmente para hepatitis C y VIH. También se constató una menor cantidad de demandas de la industria farmacéutica en los Componentes Básicos y Estratégicos de la Asistencia Farmacéutica. Los hallazgos apuntan a la tensión entre la expresiva participación de la industria como solicitante, alta movilización en las consultas públicas y énfasis en los medicamentos del Componente Especializado y la resistencia de CONITEC a esta presión, con una tendencia de mayor negativa y mayor participación de otros solicitantes en las solicitudes de ampliación del uso, exclusión e incorporación de medicamentos menos requeridos por la industria farmacéutica.

https://doi.org/10.1590/0102-311xpt233321

11.

Repercussões da infodemia associada ao COVID-19 na saúde mental do idoso no Brasil
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Bezerra Cavalcante, Ricardo

; da Costa Carbogim, Fabio

; Fávero Bulgarelli, Alexandre

; Mello dos Santos, Camila

; Queiroz Ribeiro, Andréia

; Carvalho Pinto, Ione

; Machado Zacharias, Fabiana Costa

; Aparecida Fabriz, Luciana

; Moura de Oliveira, Deíse

; Toledo de Mendonça, Erica

; Ricardo Moreira, Tiago

; Miranda Machado, Richardson

; Ribeiro Bitencourt, Graziele

; Alfradique de Souza, Priscilla

; Fereira Santana, Rosimere

; Cabreira Panitz Cruz, Gylce Eloisa

; Rezende Freitas, Eduarda

; Salmazo da Silva, Henrique

; Viana Cruz, Fabiana

; Silva Fhon, Jack Roberto

; Shizuê Kitamura, Elisa

; Gonçalves Leite, Isabel Cristina

; Rodrigues Braz, Patricia

; Consolação dos Santos, Regina

; Prado Rocha, Flávia

; Aparecida Silva, Eveline

; Barreiros Tavares, Thais

; Duarte Martins, Jerusa Gonçalves

; Alves de Araújo Püschel, Vilanice

Revista Cubana de Información en Ciencias de la Salud

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2022, Volume 33 elocation e1871

Resumo: En Pt Es | Texto: En Pt Es | PDF: En | PDF: Pt | PDF: Es

ABSTRACT The phenomenon called infodemia refers to the increase in the volume of information on a specific topic, which multiplies rapidly in a short period of time, and has stood out in the context of the health crisis triggered by the COVID-19 pandemic. Too much information can trigger feelings of fear, anxiety, stress, and other conditions of mental distress. The study aims to describe the profile of exposure to information about COVID-19 and its repercussions on the mental health of elderly Brazilians. This is a cross-sectional study carried out with 1924 elderly Brazilians. Data were collected through a web-based survey sent to the elderly via social networks and email, from July to October 2020. The results of the descriptive analysis of the data show that most of the elderly were aged between 60 and 69 years (69.02%), female (71.26%), married (53.79%) and white (75.57%). About 21.67% (n = 417) concluded their graduation, 19.75% (380) concluded their specialization and 16.63% (320) concluded their master's or doctoral degrees. Television 862 (44.80%) and social networks 651 (33.84%) were reported as frequent sources of exposure to news or information about COVID-19. Participants indicated that television (46.47%; n = 872), social networks (30.81%; n = 575) and radio (14.48%; 251) affected them psychologically and/or physically. Receiving fake news about COVID-19 on television (n = 482; 19.8%) and on social media (n = 415; 21.5%) mainly resulted in stress and fear. The disseminated information contributes to awareness, but also affects physically and/or psychologically many elderly people, mainly generating fear and stress.

RESUMO: O fenômeno denominado infodemia refere-se ao aumento do volume informacional sobre um tema em específico, que se multiplica rapidamente em um curto período de tempo, e tem-se destacado frente ao contexto da crise sanitária desencadeada pela pandemia de COVID-19. O excesso de informações pode suscitar sentimentos de medo, ansiedade, estresse e outras condições de sofrimento mental. O estudo tem como objetivo descrever o perfil de exposição a informações sobre COVID-19 e suas repercussões na saúde mental de idosos brasileiros. Trata-se de um estudo transversal realizado com 1924 idosos brasileiros. Coletaram-se dados por meio de web-based survey enviada aos idosos por redes sociais e e-mail, no período de julho a outubro de 2020. Os resultados da análise descritiva dos dados demonstram que a maioria dos idosos apresentou idade entre 60 e 69 anos (69,02%), é do sexo feminino (71,26%), casados (53,79%) e de cor branca (75,57%). Cerca de 21,67% (n = 417) concluíram a graduação, 19,75% (380) concluíram especialização e 16,63% (320) concluíram mestrado ou doutorado. Foram reportados como fontes frequentes de exposição às notícias ou informações sobre a COVID-19, a televisão 862 (44,80%) e as redes sociais 651 (33,84%). Os participantes assinalaram que a televisão (46,47%; n = 872), as redes sociais (30,81%; n = 575) e o rádio (14,48%; 251) os afetavam psicológica e/ou fisicamente. Receber notícias falsas sobre a COVID-19 pela televisão (n = 482; 19,8%) e pelas redes sociais (n = 415; 21,5%) repercutiu, principalmente, estresse e medo. As informações disseminadas contribuem para conscientização, mas, também, afetam física e/ou psicologicamente muitos idosos, principalmente gerando medo e estresse.

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12.

A indústria farmacêutica interfere na sustentabilidade do sistema de saúde pública no Brasil? Uma reflexão sobre a pressão por incorporação de medicamentos
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Tamachiro, Susanna Tawata

; Gonçalves, Fabio Augusto Rodrigues

; Simone, Adriane Lopes Medeiros

; Aguiar, Patricia Melo

Cadernos de Saúde Pública

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2022, Volume 38 Nº 7 elocation e00233321

Resumo: Es Pt En | Texto: Es Pt En | PDF: Es | PDF: Pt | PDF: En

https://doi.org/10.1590/0102-311xpt233321

13.

Caracterização tecnológica da farinha de grão-de-bico variedade BRS cristalino grãodebico grão bico
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Fernandes, Thaynnara Cristina Rodrigues

; Camargos, Luiz Fernando de Camilo, Patrícia Aparecida Jesus, Flávio Gonçalves de Siqueira, Ana Paula Silva

Brazilian Journal of Food Technology

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2022, Volume 25 elocation e2021082

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo O grão-de-bico é uma oleaginosa de elevada importância comercial e seu cultivo tem sido adaptado para as condições do Cerrado brasileiro. Diante disso, é necessário realizar pesquisas que envolvam essas espécies adaptadas, como o BRS Cristalino, para possibilitar uma maior inserção e expansão neste bioma. Este estudo avaliou características de composição físico-química e tecnológicas do grão cru e seco naturalmente, moído e refinado (farinha). As avalições realizadas foram de umidade, resíduo mineral fixo, lipídeos, proteína, fibras totais, carboidratos e valor energético. A capacidade de absorver água, óleo e leite, e as propriedades gelificantes foram analisadas como propriedades possivelmente interessantes para processos de industrialização. A farinha de grão-de-bico apresentou composição semelhante à da farinha de outras oleaginosas, com teor proteico próximo a 16%, teor de carboidrato de 61% e fibra total de 10%. Os índices tecnológicos demonstraram afinidade maior com água e leite, e boa capacidade de gelificação. A partir desses resultados, preparações com farinha de grão-de-bico como ingrediente em produtos alimentícios são motivadas. grãodebico bico brasileiro disso adaptadas Cristalino bioma físicoquímica físico química naturalmente farinha. . (farinha) umidade fixo lipídeos proteína totais energético leite industrialização oleaginosas 16 16% 61 10 10% gelificação resultados motivadas (farinha 1 6

Abstract The chickpea is an oilseed of high commercial importance and its cultivation was adapted to the conditions of the Brazilian Cerrado. Therefore, studies involving these adapted varieties are necessary, such as BRS Cristalino, in order to enable greater insertion and expansion in this biome. This study evaluated the physicochemical composition and technological characteristics of the raw and naturally dried grains, after being ground and refined. The evaluations carried out were associated with moisture, fixed mineral residue, lipids, protein, total fibers, carbohydrates and energy value. The ability to absorb water, oil and milk and also gelling properties were analyzed as possibly interesting properties for industrialization processes. This composition was similar to the flour of other oilseeds with protein content close to 16%, mineral residue of 2%, carbohydrates of 61% and total fibers of 10%. The technological indexes showed relevant affinity for water and milk and also good gelation capacity. According to these results, preparations with chickpea flour as an ingredient in food products are motivated. Cerrado Therefore necessary Cristalino biome grains refined moisture lipids value processes 16 16% 2 2% 61 10 10% capacity results motivated 1 6

https://doi.org/10.1590/1981-6723.08221

14.

Relationship between BsmI polymorphism and VDR gene methylation profile, gender, metabolic profile, oxidative stress, and inflammation in adolescents
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Lucena, Lavoisiana Lacerda de Silva, Alexandre Sérgio Nascimento, Rayner Anderson Ferreira do Persuhn, Darlene Camati Neves, Juliana Padilha Ramos Costa, Maria José de Carvalho Queiroz, Dayanna Joyce Marques Cavalcanti de Lima, Rafaela Lira Formiga Lima, Raquel Patrícia Ataíde Paiva, Maria Paula de Oliveira, Naila Francis Paulo de Gonçalves, Maria da Conceição Rodrigues

Nutrición Hospitalaria

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Out 2021, Volume 38 Nº 5 Páginas 911 - 918

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract Background: the biological activity of vitamin D depends on the activity of its receptor or VDR. On the other hand, the activity of this receptor is influenced by its state of methylation. The objective of this study was to verify if the BsmI polymorphism of the VDR gene influences its methylation profile in adolescents. Secondly, it was to verify if the status of some metabolic factors (oxidative stress, inflammation, lipid profile, and glycemia) in the serum, and gender-adjusted vitamin D levels are independent factors with an influence on the VDR methylation profile. Methods and results: the study included 198 adolescents of both sexes, aged 15-19 years, who underwent testing for VDR gene methylation polymorphisms, serum vitamin D levels, and metabolic, oxidative stress, and systemic inflammation markers. It was observed that the BB genotype was less methylated than the other groups (26.1 % versus 30.3 %, and 29.3 % for Bb and bb, respectively), although without statistical differences between them. The odds ratio indicated a protection of 13 % (partially methylated) for vitamin D status, while alpha glycols increased the risk ratio (of being partially methylated) by 3 %. MDA was protective at a 28 % chance of risk that adolescents with higher levels of lipid peroxidation would be hypomethylated. Conclusion: we conclude that the methylation profile of the VDR gene is not influenced by the different BsmI polymorphism genotypes, and that serum vitamin D and serum markers of oxidative stress and inflammation can modulate this profile.

Resumen Antecedentes: la actividad biológica de la vitamina D depende de la actividad de su receptor, el VDR. Por otro lado, la actividad de este receptor está influenciada por su estado de metilación. El objetivo de este estudio es verificar si el polimorfismo BsmI del gen VDR influye en el perfil de metilación del mismo en los adolescentes. En segundo lugar, verificar si los factores metabólicos (estrés oxidativo, inflamación, perfil lipídico y glucemia) del suero y la vitamina D ajustada por sexo actúan independientemente de los polimorfismos sobre el perfil de metilación del VDR. Métodos y resultados: el estudio incluyó a 198 adolescentes de ambos sexos, de 15 a 19 años de edad, que se sometieron a análisis de polimorfismos de metilación del gen VDR, niveles de vitamina D, marcadores metabólicos, estrés oxidativo e inflamación sistémica. Se observó que el genotipo BB estaba menos metilado que los otros grupos (26,1 % contra 30,3 % y 29,3 % para Bb y bb respectivamente), aunque sin diferencias estadísticas entre ellos. El odds ratio indicó una protección del 13 % (parcialmente metilado) para el estado de la vitamina D, mientras que los alfa glicoles aumentaron el índice de riesgo (de estar parcialmente metilado) en un 3 %. La MDA fue protectora con un 28 % de probabilidad de riesgo de que los adolescentes con niveles más altos de peroxidación lipídica fueran hipometilados. Conclusión: concluimos que el perfil de metilación del gen VDR no está influenciado por los diferentes genotipos del polimorfismo BsmI y que la vitamina D y los marcadores de estrés oxidativo e inflamación en el suero pueden modular este perfil.

https://doi.org/10.20960/nh.03383

15.

Relationship between obstructive sleep apnea syndrome and functional capacity in patients with diabetes mellitus type 2: an observational transversal study
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Fonseca, Moyrane Abreu da

; Moreira, Alana Karina Silva

; Lima, Railsa Bertilla dos Santos

; Oliveira, Marcela de Araújo

; Santos-de-Araújo, Aldair Darlan

; Rêgo, Adriana Sousa

; Penha, Ludmilia Rodrigues Lima Neuenschwander

; Ferreira, Patrícia Rodrigues

; Gonçalves, Maria Cláudia

; Bassi-Dibai, Daniela

Revista da Associação Médica Brasileira

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Jun 2021, Volume 67 Nº 6 Páginas 878 - 881

Resumo: En | Texto: En | PDF: En

SUMMARY OBJECTIVE: The aim of this study was to verify the association among obstructive sleep apnea, functional capacity, and metabolic control. METHODS: This was a cross-sectional study involving individuals of both sexes with clinical diagnosis of diabetes mellitus type 2 who were above 18 years of age. The assessment consisted of a volunteer identification form, a 2-minute step test, and the Stop-Bang questionnaire. In order to assess metabolic control, HbA1c and fasting glucose data were collected from medical records. RESULTS: A total of 100 individuals with diabetes mellitus type 2, of whom 61% were women, were included in this study. According to the Stop-Bang instrument, 26, 57, and 17% of patients had low, intermediate, and high risk of developing OSA, respectively. There was no association between the 2-minute step test and metabolic variables and diabetes mellitus type 2 chronicity with Stop-Bang. CONCLUSIONS: We concluded that there is no association among obstructive sleep apnea measured by means of Stop-Bang instrument, functional capacity measured by means of 2-minute step test, and metabolic variables in individuals with diabetes mellitus type 2.

https://doi.org/10.1590/1806-9282.20210232 44 downloads

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