ABSTRACT: This research evaluated different rice genotypes regarding physicochemical and instrumental parameters of grain quality and associated the data with sensory analysis to support the creation of rules for classification of the culinary quality of rice (texture), based on isolated or combined parameters. The combination of amylose content and gelatinization temperature was able to predict the rice quality. According to the sensorial panel, the instrumental stickiness was able to segregate rice with very low amylose content or waxy to the other ones. Regarding pasting properties, rice that presented high final viscosity (310-480 RVU), setback (165-245 RVU), and pasting temperature (78 - 88 °C), and low values for breakdown (15-120 RVU), associated with a high stickiness (>-5N) was desirable by the Brazilian consumers. The classification rules created through the relationship between the physicochemical parameters and the texture profile evaluated by the sensory panel will help to verify the culinary profile of the rice samples (through free software), which makes it easier to predict the probability of rice meeting the desired quality standards. ABSTRACT texture, , (texture) ones properties 310480 310 480 (310-48 RVU, RVU RVU) 165245 165 245 (165-24 78 (7 8 °C, C °C °C) 15120 15 120 (15-12 >5N 5N N > (>-5N consumers software, software software) standards (texture 31048 31 48 (310-4 16524 16 24 (165-2 7 ( 1512 1 12 (15-1 3104 3 4 (310- 1652 2 (165- 151 (15- (310 (165 (15 (31 (16 (1 (3

RESUMO: Este trabalho avaliou diferentes genótipos de arroz quanto a parâmetros físico-químicos e instrumentais de qualidade do grão e associou os dados à análise sensorial para subsidiar a criação de regras de classificação da qualidade culinária do arroz (textura), com base em parâmetros isolados ou combinados. A combinação do teor de amilose e temperatura de gelatinização foi capaz de predizer a qualidade do arroz. De acordo com o painel sensorial, a pegajosidade instrumental foi capaz de segregar arroz com baixo teor de amilose ou ceroso dos demais. Em relação às propriedades de pasta, o arroz que apresentou alta viscosidade final (310-480RVU), retrogradação (165-245RVU) e temperatura de pasta (78-88 °C) e baixos valores de quebra pasta (15-120RVU), associados a uma alta pegajosidade (> -5N) será desejável pelos consumidores brasileiros. As regras de classificação criadas por meio da relação entre os parâmetros físico-químicos e o perfil de textura avaliado pelo painel sensorial ajudarão a verificar o perfil culinário das amostras de arroz (por meio de um software livre), o que torna mais fácil prever a probabilidade de o arroz atender aos padrões de qualidade desejados. RESUMO físicoquímicos físico químicos textura, , (textura) combinados demais 310480RVU, 310480RVU RVU 310 480RVU (310-480RVU) 165245RVU 165 245RVU (165-245RVU 7888 78 88 (78-8 °C C 15120RVU, 15120RVU 15 120RVU (15-120RVU) > ( 5N N -5N brasileiros livre, livre livre) desejados (textura 31 (310-480RVU 16 788 7 8 (78- 1 (15-120RVU 3 (78 (7

Abstract This study aimed to evaluate in vitro the effect protocols and anticaries agents containing casein amorphous calcium fluoride phosphopeptide-phosphate (CPP-ACPF, MI Paste Plus), sodium trimetaphosphate (TMP) and fluoride (F), in remineralization of caries lesions. Bovine enamel blocks with initial caries lesions were divided into groups (n = 12): 1) Toothpaste without F-TMP-MI Plus (Placebo); 2) Toothpaste 1100 ppm F (1100F), 3) 1100F + MI Paste Plus (1100F-MI Paste Plus), 4) Toothpaste with 1100F + Neutral gel with 4,500 ppm F + 5%TMP (1100F + Gel TMP) and 5) Toothpaste with 1100F + Neutral gel with 9,000 ppm F (1100F + Gel F). For the 4 and 5 groups the gel was applied only once for 1 minute, initially to the study. For the 3 group, after treatment with 1100F, MI Paste Plus was applied 2x/day for 3 minute. After pH cycling, the percentage of surface hardness recovery (%SHR); integrated loss of subsurface hardness (ΔKHN); profile and depth of the subsuperficial lesion (PLM); concentrations of F, calcium (Ca) and phosphorus (P) in enamel was determined. The data were analyzed by ANOVA (1-criterion) and Student-Newman-Keuls test (p < 0.001). Treatment with 1100F alone led to ~ 28% higher remineralization when compared to treatment with 1100F associated with MI Paste Plus (p < 0.001). The 1100F and 1100F + Gel F groups showed similar values for %SHR (p = 0.150). 1100F + Gel TMP treatment also remineralized the enamel surface by ~ 30% and 20% when compared to the 1100F + Gel F and 1100F groups (p < 0.001). The lower lesion depth (ΔKHN) was observed for the 1100F + Gel TMP group (p < 0.001), where it was 54% and 44% lower in comparison to the 1100F and 1100F + Gel F groups (p < 0.001). Polarized light microscopy photomicrographs showed subsurface lesions in all groups, but these lesions were present to a lower extent in the 1100F + Gel TMP group (p < 0.001). Treatment with 1100F + Gel TMP promoted an increase in the concentration of Ca in the enamel by ~ 57% and ~ 26% when compared to the 1100F and 1100F + MI Paste Plus groups (p < 0.001), respectively. There were no significant differences between the 1100F, 1100F + MI Paste Plus and 1100F + Gel F groups (p > 0.001). Similar values of P in the enamel were observed in the 1100F, 1100F + MI Paste Plus and 1100F + Gel F groups (p > 0.001), except for the 1100F + Gel TMP group, which presented a high concentration (p < 0.001). We conclude that the 1100F+TMP gel treatment/protocol led to a significant increased remineralization when compared to the other treatments/protocols and may be a promising strategy for patients with early caries lesions. phosphopeptidephosphate phosphopeptide phosphate CPPACPF, CPPACPF CPP ACPF, ACPF (CPP-ACPF Plus, , Plus) (TMP (F) n 12 12) FTMPMI Placebo (Placebo) 2 110 (1100F) 1100FMI FMI 4500 500 4,50 5TMP 9000 9 000 9,00 F. . F) minute 2xday xday 2x day x cycling SHR (%SHR) ΔKHN PLM (PLM) (Ca (P determined 1criterion criterion (1-criterion StudentNewmanKeuls Student Newman Keuls p 0.001. 0001 0.001 0 001 0.001) 28 0.150. 0150 0.150 150 0.150) 30 20 (ΔKHN 0.001, 54 44 57 26 respectively 1100FTMP FTMP treatmentprotocol protocol treatmentsprotocols treatments (F (Placebo 11 450 50 4,5 900 00 9,0 (%SHR (PLM 0.00 015 0.15 15 45 4, 90 9, 0.0 01 0.1 0.

Abstract Introduction Turner syndrome (TS) affects ~ 1 in 2,500 live births. The presence of hearing alterations is one of the comorbidities found in this syndrome. Objective The present study aimed to evaluate the central auditory abilities in TS and to associate the alterations found with the cytogenetic pattern of the syndrome. Methods We included children and adults aged 9 to 39 years old, diagnosed with TS, with numerical or structural alterations of sex chromosomes in their karyotype. A battery of behavioral tests of central auditory processing (CAP) was performed, including a test within the modalities: monoaural low-redundancy, dichotic listening, binaural interaction, and temporal processing (resolution and ordering). We studied auditory skills in the total sample and in the sample stratified by age, divided into groups: G1 (9 to 13 years old), G2 (14 to 19 years old), and G3 (20 to 31 years old). For the association of the cytogenetic pattern, the division was T1 (chromosome monosomy X), and T2 (other TS cytogenetic patterns). Statistical analysis presented data expressed as median and interquartile range for numerical data and as frequency and percentage for categorical data. Results We found alterations in four auditory skills in the three age groups, but there was a statistically significant difference between the age groups only in the Gaps in Noise Test (GIN) (p-value = 0.009). Regarding karyotype, a greater number of alterations in the T1 cytogenetic pattern (chromosome monosomy X) was observed in four auditory skills, but without a statistically significant difference. Conclusion The alterations found point to an impairment in CAP in TS. (TS 2500 2 500 2,50 births 3 old karyotype (CAP performed modalities lowredundancy, lowredundancy low redundancy, redundancy low-redundancy listening interaction resolution ordering. ordering . ordering) G ( , old) 14 (1 20 (2 old. T chromosome X, X other patterns. patterns patterns) GIN (GIN pvalue p value 0.009. 0009 0.009 0 009 0.009) 250 50 2,5 000 0.00 00 25 5 2, 0.0 0.

ABSTRACT Objective: To identify environmental factors that favor monitoring care effectiveness indicators in the dimensions of safety and patient-centered care in hospitals. Method: Qualitative research with multiple cases study, carried out in three hospitals in south Brazil, involving 58 participants. Data was collected between June 2020 and December 2021 through questionnaires, interviews, focus groups, and institutional documents subjected to categorical content analysis. Results: The following categories were identified: internal and external environmental factors; and subcategories: convergent and non-convergent, namely: internal convergent - strategic planning and management support for quality management, information systems, and institutional strategies, methods and procedures; internal non-convergent: public teaching hospital; and external convergent - public policies and epidemiological factors; and non-convergent - accrediting agency and hospital network. Conclusion: Factors favoring the monitoring of effectiveness indicators were found in the dimensions considered, which elucidate good quality management practices that are useful and relevant to Brazilian hospitals. Objective patientcentered patient centered Method study Brazil 5 participants 202 questionnaires interviews groups analysis Results identified subcategories nonconvergent, nonconvergent non convergent, namely systems strategies procedures network Conclusion considered 20 2

RESUMEN Objetivo: Identificar los factores ambientales que favorecen el seguimiento de los indicadores de eficacia asistencial en las dimensiones de seguridad y atención centrada en el paciente en los hospitales. Método: investigación cualitativa con estudio de casos múltiples, realizada en tres hospitales del sur de Brasil, con 58 participantes. Datos recopilados entre junio de 2020 y diciembre de 2021 mediante cuestionarios, entrevistas, grupos de discusión y documentos institucionales, sometidos a un análisis de contenido categórico. Resultados: se identificaron las siguientes categorías: factores ambientales internos y externos; y subcategorías: convergentes y no convergentes, a saber: internos convergentes: planificación estratégica y apoyo de la dirección a la gestión de la calidad, sistemas de información y estrategias, métodos y procedimientos institucionales; internos no convergentes: hospital de enseñanza pública; y externos convergentes: políticas públicas y factores epiHubo factores que favorecieron el seguimiento de los indicadores de eficacia en las dimensiones consideradas, que dilucidan buenas prácticas de gestión de la calidad útiles y pertinentes para los hospitales brasileños. Objetivo Método múltiples Brasil 5 participantes 202 cuestionarios entrevistas institucionales categórico Resultados categorías subcategorías saber estrategias pública consideradas brasileños 20 2

RESUMO Objetivo: identificar fatores ambientais que favorecem o monitoramento de indicadores de efetividade assistencial nas dimensões segurança e cuidado centrado no paciente em hospitais. Método: pesquisa qualitativa com estudo de casos múltiplos, desenvolvida em três hospitais do sul do Brasil, envolvendo 58 participantes. Dados coletados entre junho/2020 e dezembro/2021 mediante questionários, entrevistas, grupos focais, documentos institucionais, submetidos à análise de conteúdo categorial. Resultados: evidenciaram-se categorias: fatores ambientais internos e externos; e subcategorias: convergentes e não convergentes, a saber: internos convergentes - planejamento estratégico e apoio da Direção à gestão da qualidade, sistemas de informação e estratégias, métodos e procedimentos institucionais; interno não-convergente: hospital de ensino público; e externos convergentes - políticas públicas e fatores epidemiológicos; e não-convergentes - agência acreditadora e rede hospitalar. Conclusão: evidenciaram-se fatores favorecedores do monitoramento de indicadores de efetividade nas dimensões consideradas, que elucidam boas práticas de gestão da qualidade, úteis e relevantes aos hospitais brasileiros. Objetivo Método múltiplos Brasil 5 participantes junho2020 junho 2020 junho/202 dezembro2021 dezembro 2021 dezembro/202 questionários entrevistas focais institucionais categorial Resultados evidenciaramse evidenciaram se categorias subcategorias saber qualidade estratégias nãoconvergente convergente não-convergente público epidemiológicos nãoconvergentes hospitalar Conclusão consideradas brasileiros junho202 202 junho/20 dezembro202 dezembro/20 junho20 20 junho/2 dezembro20 dezembro/2 junho2 2 junho/ dezembro2 dezembro/

ABSTRACT In conjunction with experimental studies, computational tools based on the Finite Element Method (FEA) have made it possible to analyze the phenomenon of punching and the influence of prestressing on the ultimate strength of flat slabs and thus understand this phenomenon through numerical simulations. In this study, experimental tests were simulated through three-dimensional analyses, using the constitutive models implemented in the ATENA 3D computer program, it was possible to validate the numerical results through the load-displacement and load-strain curves being compared with the experimental curves. The numerical results showed a difference in load capacity of less than 2% for the experimental models. After adequate calibration, a parametric study with eight models of prestressed slabs was implemented by varying the spacing and eccentricity of the prestressing tendons, punching resistance being evaluated with the new parameters. The punching resistant capacity of each model was also compared with the most current regulatory design predictions. studies FEA (FEA simulations threedimensional three dimensional analyses D program loaddisplacement displacement loadstrain strain 2 calibration tendons parameters predictions

ABSTRACT BACKGROUND: The risk of death due to tuberculosis (TB) in Brazil is high and strongly related to living conditions (LC). However, epidemiological studies investigating changes in LC and their impact on TB are lacking. OBJECTIVES: To evaluate the impact of LC on TB mortality in Brazil. DESIGN AND SETTING: This ecological study, using panel data on spatial and temporal aggregates, was conducted in 1,614 municipalities between 2002 and 2015. METHODS: Data were collected from the Mortality Information System and the Brazilian Institute of Geography and Statistics. The proxy variable used for LC was the Urban Health Index (UHI). Negative binomial regression models were used to estimate the effect of the UHI on TB mortality rate. Attributable risk (AR) was used as an impact measure. RESULTS: From 2002 to 2015, TB mortality rate decreased by 23.5%, and LC improved. The continuous model analysis resulted in an RR = 0.89 (95%CI = 0.82–0.96), so the AR was −12.3%. The categorized model showed an effect of 0.92 (95%CI = 0.83–0.95) in municipalities with intermediate LC and of 0.83 (95%CI = 0.82–0.91) in those with low LC, representing an AR for TB mortality of −8.7% and −20.5%, respectively. CONCLUSIONS: Improved LC impacted TB mortality, even when adjusted for other determinants. This impact was greater in the strata of low-LC municipalities. BACKGROUND (TB LC. . (LC) However lacking OBJECTIVES SETTING study aggregates 1614 1 614 1,61 200 2015 METHODS Statistics UHI. (UHI) (AR measure RESULTS 235 23 5 23.5% improved 089 0 89 0.8 95%CI 95CI CI 95 0.82–0.96, 082096 0.82–0.96 , 82 96 0.82–0.96) 123 12 3 −12.3% 092 92 0.9 0.83–0.95 083095 83 083 0.82–0.91 082091 91 87 8 7 −8.7 205 20 −20.5% respectively CONCLUSIONS determinants lowLC (LC 161 61 1,6 201 (UHI 2 23.5 08 0. 9 08209 0.82–0.9 −12.3 09 0.83–0.9 08309 −8. −20.5 16 6 1, 23. 0820 0.82–0. −12. 0.83–0. 0830 −8 −20. 082 0.82–0 −12 0.83–0 − −20 0.82– −1 0.83– −2 0.82

The aim of this study was to analyze visual communication media displayed in the reception areas of Primary Care Centers (PCCs). We conducted a qualitative study of 16 PCCs in Içara, Santa Catarina, Brazil. We took photographs of the media and conducted a semiotic analysis involving the following stages: selection of images, denotative inventory, analysis of levels of meaning, cessation decision and reporting. The data were organized using ATLAS.ti 22. The results indicated five categories of media: health care support materials (38.5%); information on PCCs (26.7%); PCC structural problems (15.7%); health team patient recommendations (15.7%); and decorative objects (3.4%). PCCs should display few support materials and notices in the reception area; furniture needs to be in good condition; bright colors, exposed electric cables, damaged floors and religious symbols should be avoided. PCCs. . (PCCs) 1 Içara Catarina Brazil stages images inventory meaning reporting ATLASti ATLAS ti 22 38.5% 385 38 5 (38.5%) 26.7% 267 26 7 (26.7%) 15.7% 157 15 (15.7%) 3.4%. 34 3.4% 3 4 (3.4%) area condition colors cables avoided (PCCs 2 38.5 (38.5% 26.7 (26.7% 15.7 (15.7% 3.4 (3.4% 38. (38.5 26. (26.7 15. (15.7 3. (3.4 (38. (26. (15. (3. (38 (26 (15 (3 (2 (1 (

O estudo objetiva analisar comunicações visuais dispostas na recepção de Unidades Básicas de Saúde (UBS). Trata-se de um estudo qualitativo, realizado em 16 UBS do município de Içara, estado de Santa Catarina, Brasil. Foi realizado um registro fotográfico, conforme análise semiótica, que envolveu escolha das imagens, inventário denotativo, estabelecimento de níveis de significação, decisão de cessação e relatório. Para organização dos dados, foi utilizado o software Atlas.ti 22. Os resultados indicaram cinco categorias: materiais de apoio ao processo de trabalho em saúde (38,5%), informações sobre as UBS (26,7%), dificuldades estruturais das UBS (15,7%), recomendações da equipe de saúde aos usuários (15,7%) e objetos decorativos das recepções em UBS (3,4%). As UBS devem possuir suas recepções com poucos materiais de apoio e informes; o mobiliário precisa estar em condições adequadas; e cores muito fortes, fios elétricos expostos, pisos danificados e simbologia religiosa devem ser evitadas. UBS. . (UBS) Tratase Trata se qualitativo 1 Içara Catarina Brasil fotográfico semiótica imagens denotativo significação relatório dados Atlasti Atlas ti 22 categorias 38,5%, 385 38,5% , 38 5 (38,5%) 26,7%, 267 26,7% 26 7 (26,7%) 15,7%, 157 15,7% 15 (15,7% 3,4%. 34 3,4% 3 4 (3,4%) informes adequadas fortes expostos evitadas (UBS 2 38,5 (38,5% 26,7 (26,7% 15,7 (15,7 3,4 (3,4% 38, (38,5 26, (26,7 15, (15, 3, (3,4 (38, (26, (15 (3, (38 (26 (1 (3 (2 (

El objetivo del estudio es analizar comunicaciones visuales dispuestas en la recepción de Unidades Básicas de Salud (UBS). Se trata de un estudio cualitativo, realizado en 16 UBS del municipio de Içara, estado de Santa Catarina, Brasil. Se realizó un registro fotográfico, conforme análisis semiótico, a saber: elección de las imágenes, inventario denotativo, niveles de significación, decisión de cese e informe. Para la organización de los datos se utilizó el Atlas.ti 22. Los resultados indicaron 5 categorías: materiales de apoyo al proceso de trabajo en salud (38,5%); informaciones sobre las UBS (26,7%); dificultades estructurales de las UBS (15,7%); recomendaciones del equipo de salud a los usuarios (15,7%); y objetos decorativos de las recepciones en UBS (3,4%). Las UBS deben tener sus recepciones con pocos materiales de apoyo e informes; el mobiliario precisa estar en condiciones adecuadas; deben evitarse colores muy fuertes, cables eléctricos expuestos, pisos dañados y simbología religiosa. UBS. . (UBS) cualitativo 1 Içara Catarina Brasil fotográfico semiótico saber imágenes denotativo significación informe Atlasti Atlas ti 22 categorías 38,5% 385 38 (38,5%) 26,7% 267 26 7 (26,7%) 15,7% 157 15 (15,7%) 3,4%. 34 3,4% 3 4 (3,4%) informes adecuadas fuertes expuestos religiosa (UBS 2 38,5 (38,5% 26,7 (26,7% 15,7 (15,7% 3,4 (3,4% 38, (38,5 26, (26,7 15, (15,7 3, (3,4 (38, (26, (15, (3, (38 (26 (15 (3 (2 (1 (

The aim of this study was to analyze visual communication media displayed in the reception areas of Primary Care Centers (PCCs). We conducted a qualitative study of 16 PCCs in Içara, Santa Catarina, Brazil. We took photographs of the media and conducted a semiotic analysis involving the following stages: selection of images, denotative inventory, analysis of levels of meaning, cessation decision and reporting. The data were organized using ATLAS.ti 22. The results indicated five categories of media: health care support materials (38.5%); information on PCCs (26.7%); PCC structural problems (15.7%); health team patient recommendations (15.7%); and decorative objects (3.4%). PCCs should display few support materials and notices in the reception area; furniture needs to be in good condition; bright colors, exposed electric cables, damaged floors and religious symbols should be avoided.

O estudo objetiva analisar comunicações visuais dispostas na recepção de Unidades Básicas de Saúde (UBS). Trata-se de um estudo qualitativo, realizado em 16 UBS do município de Içara, estado de Santa Catarina, Brasil. Foi realizado um registro fotográfico, conforme análise semiótica, que envolveu escolha das imagens, inventário denotativo, estabelecimento de níveis de significação, decisão de cessação e relatório. Para organização dos dados, foi utilizado o software Atlas.ti 22. Os resultados indicaram cinco categorias: materiais de apoio ao processo de trabalho em saúde (38,5%), informações sobre as UBS (26,7%), dificuldades estruturais das UBS (15,7%), recomendações da equipe de saúde aos usuários (15,7%) e objetos decorativos das recepções em UBS (3,4%). As UBS devem possuir suas recepções com poucos materiais de apoio e informes; o mobiliário precisa estar em condições adequadas; e cores muito fortes, fios elétricos expostos, pisos danificados e simbologia religiosa devem ser evitadas.

El objetivo del estudio es analizar comunicaciones visuales dispuestas en la recepción de Unidades Básicas de Salud (UBS). Se trata de un estudio cualitativo, realizado en 16 UBS del municipio de Içara, estado de Santa Catarina, Brasil. Se realizó un registro fotográfico, conforme análisis semiótico, a saber: elección de las imágenes, inventario denotativo, niveles de significación, decisión de cese e informe. Para la organización de los datos se utilizó el Atlas.ti 22. Los resultados indicaron 5 categorías: materiales de apoyo al proceso de trabajo en salud (38,5%); informaciones sobre las UBS (26,7%); dificultades estructurales de las UBS (15,7%); recomendaciones del equipo de salud a los usuarios (15,7%); y objetos decorativos de las recepciones en UBS (3,4%). Las UBS deben tener sus recepciones con pocos materiales de apoyo e informes; el mobiliario precisa estar en condiciones adecuadas; deben evitarse colores muy fuertes, cables eléctricos expuestos, pisos dañados y simbología religiosa.

ABSTRACT Background: Malaria is a parasitosis conditioned by several factors. This study sought to analyze the spatial distribution of malaria considering environmental, socioeconomic, and political variables in São Félix do Xingu, Pará, Brazil, from 2014 to 2020. Methods: Epidemiological, cartographic, and environmental data were obtained from the Ministry of Health, Brazilian Geographical and Statistical Institute, and National Space Research Institute. Statistical and spatial distribution analyses were performed using chi-squared tests of expected equal proportions and the kernel and bivariate global Moran’s techniques with Bioestat 5.0 and ArcGIS 10.5.1. Results: The highest percentage of cases occurred in adult males with brown skin color, mainly placer miners, with a primary education level, living in rural areas, who were infected with Plasmodium vivax and with parasitemia of two or three crosses as diagnosed by the thick drop/smear test. The disease had a non-homogeneous distribution, with distinct annual parasite indices associated with administrative districts and clusters of cases in locations with deforestation, mining, and pastures close to Conservation Units and Indigenous Lands. Thus, a direct relationship between areas with cases and environmental degradation associated with land use was demonstrated, along with the precarious availability of health services. Pressure on protected areas and epidemiological silence in Indigenous Lands were also noted. Conclusions: Environmental and socioeconomic circuits were identified for development of diseases associated with precarious health services in the municipality. These findings highlight the need to intensify malaria surveillance and contribute to the systematic knowledge of malaria’s epidemiology by considering the complexity of its conditioning factors. Background factors Xingu Pará Brazil 201 2020 Methods Epidemiological cartographic Health Institute chisquared chi squared Morans Moran s 50 5 0 5. 1051 10 1 10.5.1 Results color miners level dropsmear drop smear test nonhomogeneous non homogeneous deforestation mining Thus demonstrated noted Conclusions municipality malarias 20 202 105 10.5. 2 10.5 10.

Abstract There are no records of autochthonous cases of canine visceral leishmaniasis in the city of Curitiba, Paraná state, Brazil. In 2020, a male French bulldog (CW01), approximately 2 years old was taken by its owners to a private veterinarian clinic. The suspicion of CVL was confirmed by means of a serology test (ELISA/IFAT reagent), rapid chromatographic immunoassay (DPP®) (ELISA - Biomanguinhos®), parasitological culture and quantitative polymerase chain reaction (qPCR). The animal routinely frequented parks in Curitiba and was taken on several trips to the municipalities of Bombinhas and Balneário Camboriú (Santa Catarina) and to Matinhos (Paraná) where CVL had not previously been reported. Treatment was initiated orally with Milteforan™ which resulted in a significant reduction in the parasitic load. The suspicion of autochthony was investigated through entomological research. A total of 10 traps were installed, one at the animal’s home, seven in adjacent city blocks and two in a forest edge. No sandflies were trapped in the dog’s home and adjacent houses. The traps in the forest edge caught one Migonemyia migonei female and five Brumptomyia spp. females. This case serves as a warning of the possible introduction of CVL in the city of Curitiba. state Brazil 2020 CW01, CW01 CW , (CW01) clinic ELISA/IFAT ELISAIFAT ELISA IFAT reagent, reagent reagent) DPP® DPP (DPP® Biomanguinhos®, Biomanguinhos Biomanguinhos® Biomanguinhos®) qPCR. qPCR . (qPCR) Santa Catarina (Paraná reported Milteforan load research 1 installed animals s dogs dog houses spp females 202 CW0 (CW01 (DPP (qPCR 20 (CW0 (CW

Resumo Não há registros de casos autóctones de leishmaniose visceral canina (LVC) no município de Curitiba, Paraná, Brasil. Em 2020, um "bulldog" francês macho (CW01), com aproximadamente 2 anos de idade, foi levado por seus donos a uma clínica veterinária particular. A suspeita de LVC foi confirmada por meio de teste sorológico (reagente ELISA/IFAT), imunoensaio cromatográfico rápido (DPP®) (ELISA - Biomanguinhos®), cultura parasitológica e reação quantitativa em cadeia da polimerase (qPCR). O animal frequentava, rotineiramente, parques de Curitiba e foi levado em diversas viagens para Bombinhas e Balneário Camboriú (Santa Catarina) e para Matinhos (Paraná), onde a LVC não havia sido relatada anteriormente. O tratamento foi iniciado por via oral com Milteforan™ (Virbac) o que resultou em redução significativa da carga parasitária. A suspeita de autóctone foi investigada por meio de pesquisa entomológica. Foram instaladas 10 armadilhas, uma na casa do animal, sete em quarteirões adjacentes e duas na borda da mata. Nenhum inseto foi capturado na casa do proprietário do animal e nas casas adjacentes. As armadilhas na borda da mata capturaram uma fêmea de Migonemyia migonei e cinco Brumptomyia spp. fêmeas. Este caso serve de alerta para a possível introdução da LVC na cidade de Curitiba. (LVC Paraná Brasil 2020 bulldog "bulldog CW01, CW01 CW , (CW01) idade particular reagente ELISA/IFAT, ELISAIFAT ELISA/IFAT ELISA IFAT ELISA/IFAT) DPP® DPP (DPP® Biomanguinhos®, Biomanguinhos Biomanguinhos® Biomanguinhos®) qPCR. qPCR . (qPCR) frequentava rotineiramente Santa Catarina (Paraná) anteriormente Milteforan Virbac (Virbac parasitária entomológica 1 spp fêmeas 202 CW0 (CW01 (DPP (qPCR (Paraná 20 (CW0 (CW

Abstract Objective To verify the influence of low birth weight and rapid postnatal weight gain and associated factors on blood pressure in adolescence in a population of low socioeconomic status, considering that injuries occur in the perinatal period can be predictors of future metabolic changes and are still poorly explored. Methods A cohort study was carried out with 208 adolescents, 78 born with low weight and 130 born with appropriate weight. The infants were followed up during the first six postnatal months and reassessed at 8 and 18 years of age. The independent variables were birthweight and postnatal weight gain. Rapid postnatal weight gain was defined when above 0.67 z score. The co-variables were sex, maternal height and family income at birth, nutritional status at eight years old, socioeconomic conditions, nutritional status, fat mass index, and physical activity level at 18 years. The outcome variable was blood pressure at 18 years old. The bivariate and multivariable logistic regression analysis were realized and p < 0,05 was considered significant. Results The proportion of adolescents with elevated blood pressure was 37.5%. The multivariable logistic regression analysis showed the variables independently associated with a higher chance of elevated blood pressure in adolescence were rapid postnatal weight gain (OR = 2.74; 95% CI 1.22-6.14; p= 0.014), male sex (OR = 4.15; 95% CI 1.66-10.38; p= 0.002) and being physically active (OR = 2.70; 95% CI 1.08-6.74; p= 0.034). Conclusions The rapid postnatal weight gain was a predictor for elevated blood pressure in adolescence, independently of other factors. explored 20 7 13 1 age 067 0 67 0.6 score covariables co old conditions index 005 05 0,0 significant 375 37 5 37.5% OR 2.74 274 2 74 95 1.226.14 122614 1.22 6.14 22 6 14 1.22-6.14 0.014, 0014 0.014 , 014 0.014) 4.15 415 4 15 1.6610.38 1661038 1.66 10.38 66 10 38 1.66-10.38 0.002 0002 002 2.70 270 70 1.086.74 108674 1.08 6.74 08 1.08-6.74 0.034. 0034 0.034 . 034 0.034) 06 0. 00 0, 3 37.5 2.7 27 9 226 1.226.1 12261 122 1.2 614 6.1 1.22-6.1 001 0.01 01 4.1 41 6610 1.6610.3 166103 166 1.6 1038 10.3 1.66-10.3 0.00 000 086 1.086.7 10867 108 1.0 674 6.7 1.08-6.7 003 0.03 03 37. 2. 1.226. 1226 12 1. 61 6. 1.22-6. 0.0 4. 661 1.6610. 16610 16 103 10. 1.66-10. 1.086. 1086 1.08-6. 1.226 1.22-6 1.6610 1661 1.66-10 1.086 1.08-6 1.22- 1.661 1.66-1 1.08- 1.66-

Abstract Twenty six sweet cassava clones were evaluated in two agricultural years, in randomized block design, with 3 replications and plots with 25 plants. The harvests were at 12 months after planting, in both years. The traits evaluated were root yield (RY), dry matter content (DMC), total carotenoids content (TC), β-carotene content (BC), trans-β-carotene content (TrBC) and total cyanide content (TCy). Genotype was significant (P<0.05) in all traits. Broad-sense heritability estimates at the plot level ( h m g 2 ) ranged from 77% (RY) to 93% (TC and TrBC), while the accuracy ranged from 0.88 (RY) to 0.96 (BC and TrBC). The genetic correlations among TC, BC and TrBC were high (0.96 to 0.99) and significant, and the genetic correlations involving these traits and TCy were negative. These results demonstrate the existence of great genetic variability in characteristics important to cassava biofortification and, consequently, great perspectives in the breeding for this purpose. years design plants 1 planting RY, RY , DMC, DMC (DMC) TC (TC) βcarotene β carotene BC, (BC) transβcarotene trans (TrBC TCy. . (TCy) P<0.05 P005 P 0 05 (P<0.05 Broadsense Broad sense 77 (RY 93 TrBC, TrBC) 088 88 0.8 096 96 0.9 TrBC. (0.9 0.99 099 99 negative consequently purpose (DMC (TCy P<0.0 P00 (P<0.0 7 9 08 8 0. 09 (0. P<0. P0 (P<0. (0 P<0 (P<0 P< (P< (P

Abstract This publication is an update of the “Consensus on the therapeutic management of atopic dermatitis - Brazilian Society of Dermatology” published in 2019, considering the novel, targeted-oriented systemic therapies for atopic dermatitis. The initial recommendations of the current consensus for systemic treatment of patients with atopic dermatitis were based on a recent review of scientific published data and a consensus was reached after voting. The Brazilian Society of Dermatology invited 31 experts from all regions of Brazil and 2 international experts on atopic dermatitis who fully contributed to the process. The methods included an e-Delphi study to avoid bias, a literature search and a final consensus meeting. The authors added novel approved drugs in Brazil and the indication for phototherapy and systemic therapy for AD. The therapeutical response to systemic treatment is hereby reported in a suitable form for clinical practice and is also part of this updated manuscript. Consensus 2019 targetedoriented targeted oriented voting 3 process eDelphi e Delphi bias meeting AD manuscript 201 20

ABSTRACT Purpose: This study seeks to understand how the managers of the civil construction industry perceive risk management in their projects and businesses based on a case study in the region of Volta Redonda-RJ. Design/methodology/approach: Primary data was collected through questionnaires and interviews. The primary quantitative data were analyzed using Paraconsistent Logic and presented with descriptive statistics. Findings: It was found that 87% of the sample did not go through any steps of the risk management process. For those that did, the steps were essentially intuitive and informal. Further, a distortion was observed on behalf of the managers regarding the understanding of what risk management is, what it is helpful for, and the difference between their projects and the business itself. Practical implications: Although not generalizable, the research results show a high appetite for risk on the part of contractors but a low willingness to absorb its effects. Originality/value: Studies that apply paraconsistent logic to understand builders’ perceptions of the importance of risk management are scarce in the literature. Also, there is little literature about the management aspects of this industry. Purpose RedondaRJ. RedondaRJ Redonda RJ. RJ Redonda-RJ Design/methodology/approach Designmethodologyapproach Design methodology approach interviews statistics Findings 87 process informal Further itself implications generalizable effects Originality/value Originalityvalue Originality value builders Also 8

RESUMO Objetivo – Este estudo busca compreender como os gestores da construção civil percebem a gestão de riscos em seus projetos e negócios a partir de um estudo de caso na cidade de Volta Redonda-RJ. Método – Os dados foram coletados por meio de questionários e entrevistas. Os dados quantitativos primários foram analisados pela Lógica Paraconsistente e apresentados por meio de estatística descritiva. Resultados – Constatou-se que 87% da amostra não passou por nenhuma etapa do processo de gestão de riscos. Para aqueles que o fizeram, as etapas foram essencialmente intuitivas e informais. Além disso, observou-se uma distorção por parte dos gestores quanto ao entendimento do que é gestão de risco, para que serve e a diferença entre seus projetos e o próprio negócio. Implicações práticas – Apesar de não generalizáveis, os resultados da pesquisa mostram um alto apetite ao risco por parte dos construtores, mas baixa disponibilidade de absorção de seus efeitos. Originalidade – Estudos que aplicam Lógica Paraconsistente para entender a percepção dos construtores a respeito da importância da gestão de risco são escassos na literatura. Além disso, há pouca literatura sobre os aspectos de gestão desta indústria. RedondaRJ. RedondaRJ Redonda RJ. RJ Redonda-RJ entrevistas descritiva Constatouse Constatou se 87 fizeram informais disso observouse observou negócio generalizáveis efeitos indústria 8

Aim The aim of this study was to investigate the influence of the quantity and positioning of feldspathic ceramic specimens inside the furnace on their flexural strength and translucency. The tested hypotheses were that the arrangement of specimens in the furnance would not influence 1) the translucency or 2) the biaxial strength of the porcelain. Methods Ninety porcelain specimens were made (1.2 mm thickness and 13.5 mm diameter) and assigned into two main groups (n=15): G1 group - 15 firing cycles containing only one specimen each, always at the center of the refractory; and G5 group - 15 firing cycles containing five specimen each, where one specimen was at the center of the refractory and four specimens positioned equidistantly on the periphery. The translucency test was performed using a spectrophotometer, followed by the flexural strength test, according to ISO 6872:2015. T-student test was performed for both the mechanical and optical obtained data. Results The flexural strength of the porcelain was not affected by the positioning (center x periphery) of the specimens inside the furnace (p =0.08), but the translucency was affected (periphery > center; p =0.009). Regarding to the number of feldspathic ceramic specimens, the biaxial flexural strength was affected (p =0.025), as well as the translucency (p <0.05). Conclusion A higher quantity of feldspathic ceramic specimens for each firing cycle decreased its biaxial flexural strength and translucency. Also, specimens positioned at the center of the refractory became less translucent than those positioned at the periphery. 1 2 1.2 12 (1. 135 13 5 13. diameter n=15 n15 n (n=15) G periphery spectrophotometer 68722015. 68722015 6872 2015. 2015 6872:2015 Tstudent T student data =0.08, 008 =0.08 , 0 08 =0.08) =0.009. 0009 =0.009 . 009 =0.009) =0.025, 0025 =0.025 025 =0.025) <0.05. 005 <0.05 05 <0.05) Also 1. (1 n=1 n1 (n=15 6872201 687 201 6872:201 00 =0.0 000 =0.00 002 =0.02 02 <0.0 ( n= (n=1 687220 68 20 6872:20 =0. <0. (n= 68722 6 6872:2 =0 <0 (n 6872: = <