Abstract Objectives: to analyze the donation of human milk at the Banco de Incentivo e Apoio a Amamentação (BIAMA) (Breastfeeding Incentive and Support Bank) from 2018 to 2020. Methods: normative assessment, descriptive and exploratory character, with a quantitative approach and focus on the Donabedian Model. Study with a locus at BIAMA at Dom Malan Hospital, in the city of Petrolina-PE, based on registrations from the online platform of the Rede Brasileira de Bancos de Leite Humano (Brazilian Network of Human Milk Banks), with data from BIAMA from 2018 to 2020 and field activities. Results: in 2020, there was a decrease in the number of group assistance and medical consultations, in contrast to the increase in nursing consultations. Most of the milk supply comes from the external public, and in 2020 there was a reduction number of donors and in the volume of human milk collected. Conclusions: COVID-19 pandemic had a negative impact on BIAMA activities and on milk donation, however, the use of new means of communication for patient care was observed. Even so, new donor recruitment strategies must be implemented. Regarding the main norms that regulate the operation of Human Milk Banks, most of the items listed are obeyed by BIAMA. Objectives (BIAMA Breastfeeding Bank 201 Methods assessment character Model Hospital PetrolinaPE, PetrolinaPE Petrolina PE, PE Petrolina-PE Brazilian Banks , Banks) 202 Results consultations public collected Conclusions COVID19 COVID 19 COVID-1 however observed so implemented 20 COVID1 1 COVID- 2

Resumo Objetivos: analisar a doação de leite humano no Banco de Incentivo e Apoio a Amamentação (BIAMA) no período de 2018 a 2020. Métodos: avaliação normativa, de caráter descritivo e exploratório, com abordagem quantitativa e enfoque no Modelo Donabedian. Estudo com lócus no BIAMA do Hospital Dom Malan, na cidade de Petrolina-PE, a partir de registros da plataforma online da Rede Brasileira de Bancos de Leite Humano, com dados do BIAMA de 2018 a 2020 e atividades de campo. Resultados: em 2020, houve um decréscimo no número de atendimentos em grupo e de consultas médicas, em contrapartida, ao aumento das consultas de enfermagem. A maior parte do abastecimento de leite advém do público externo, e em 2020 foi observado uma redução no número de doadoras e no volume de leite humano coletado. Conclusões: a pandemia de COVID-19 repercutiu de forma negativa em atividades do BIAMA e na doação de leite, no entanto, foi observado a utilização de novos meios de comunicação para atendimento dos pacientes. Ainda assim, novas estratégias para recrutamento de doadoras devem ser implementadas. Em relação às principais normas que regulamentam o funcionamento de Bancos de Leite Humano, a maioria dos itens elencados são obedecidos pelo BIAMA. Objetivos (BIAMA 201 Métodos normativa exploratório Donabedian Malan PetrolinaPE, PetrolinaPE Petrolina PE, PE Petrolina-PE Humano 202 campo Resultados médicas contrapartida enfermagem externo coletado Conclusões COVID19 COVID 19 COVID-1 entanto pacientes assim implementadas 20 COVID1 1 COVID- 2

Abstract Objective: To analyze the fluoride concentration in the public water supply in Manaus, Brazil. Material and Methods: Water samples were collected in 50 mL polyethylene bottles, identified, and labeled. The collection was performed from September 2016 to August 2018. For the selection of collection points, all neighborhoods of the city of Manaus, divided into four health districts (North, South, East, and West), were mapped. From each district, 30 samples were collected, totaling 120 monthly samples. Water samples were analyzed using an ion analyzer, ORION 720-A, and a specific electrode, ORION 96-09. The ion analyzer and electrode were calibrated in standard solutions. The levels were classified in intervals based on technical consensus to guide the health surveillance agencies. Results: Of the 2,874 water samples, 50.3% were within the recommended range, and 49.7% were inadequate, with 31.6% considered above the parameters and 18.1% below. Among the districts, the North had the highest percentages of unsatisfactory samples, resulting in limited action to prevent tooth decay. During the 24 months of analysis, there were large oscillations in the values in all four districts of Manaus. Conclusion: Results reinforce the importance of heterocontrol for the city to guarantee the effectiveness of this public health measure.

RESUMO O objetivo deste artigo foi apresentar um método qualitativo de abordagem da educação ambiental no processo de territorialização em saúde. O percurso metodológico que dá origem a este texto é uma pesquisa-ação cujo estudo é do tipo exploratório e descritivo de abordagem qualitativa por meio do desenvolvimento de oficinas. Foram realizados seis encontros para atender aos objetivos propostos. As atividades foram desenvolvidas por um moderador e contaram com a participação de 60 Agentes Comunitários de Saúde atuantes em um município de pequeno porte do interior e do litoral da Bahia. Os resultados apontam que, no processo de territorialização em saúde, é elementar a incorporação de novas práticas que demonstrem o território além de demarcações geográficas, valorizando a concepção ampliada de ambiente e suas relações com a saúde. Nesse ponto, surge como proposta a reorganização dos processos de trabalho, no sentido de buscar multidisciplinaridade, interdisciplinaridade e participação efetiva no processo de territorialização em saúde à luz da educação ambiental.

ABSTRACT This paper aims to present a method of qualitative approach to environmental education in the process of territorialization in health. The methodological path that gives rise to this text is an action-research whose study is exploratory and descriptive of qualitative approach through the development of workshops. Six meetings were held to meet the proposed objectives. The activities were developed by a moderator and were attended by 60 Community Health Workers working in a small municipality in both the countryside and the coast of Bahia. The results indicate that, in the process of territorialization in health, it is elementary to incorporate new practices that demonstrate the territory beyond geographical demarcations, valuing the broader conception of the environment and its relations with health. In that regard, the proposal that arises is the reorganization of work processes, in the sense of seeking multidisciplinarity, interdisciplinarity and effective participation in the process of territorialization in health, in light of environmental education.

RESUMO O objetivo deste artigo foi apresentar um método qualitativo de abordagem da educação ambiental no processo de territorialização em saúde. O percurso metodológico que dá origem a este texto é uma pesquisa-ação cujo estudo é do tipo exploratório e descritivo de abordagem qualitativa por meio do desenvolvimento de oficinas. Foram realizados seis encontros para atender aos objetivos propostos. As atividades foram desenvolvidas por um moderador e contaram com a participação de 60 Agentes Comunitários de Saúde atuantes em um município de pequeno porte do interior e do litoral da Bahia. Os resultados apontam que, no processo de territorialização em saúde, é elementar a incorporação de novas práticas que demonstrem o território além de demarcações geográficas, valorizando a concepção ampliada de ambiente e suas relações com a saúde. Nesse ponto, surge como proposta a reorganização dos processos de trabalho, no sentido de buscar multidisciplinaridade, interdisciplinaridade e participação efetiva no processo de territorialização em saúde à luz da educação ambiental.

ABSTRACT This paper aims to present a method of qualitative approach to environmental education in the process of territorialization in health. The methodological path that gives rise to this text is an action-research whose study is exploratory and descriptive of qualitative approach through the development of workshops. Six meetings were held to meet the proposed objectives. The activities were developed by a moderator and were attended by 60 Community Health Workers working in a small municipality in both the countryside and the coast of Bahia. The results indicate that, in the process of territorialization in health, it is elementary to incorporate new practices that demonstrate the territory beyond geographical demarcations, valuing the broader conception of the environment and its relations with health. In that regard, the proposal that arises is the reorganization of work processes, in the sense of seeking multidisciplinarity, interdisciplinarity and effective participation in the process of territorialization in health, in light of environmental education.

Abstract Chemotherapy is one of the major approaches for the treatment of cancer. Therefore, the development of new chemotherapy drugs is an important aspect of medicinal chemistry. Chemotherapeutic agents include isocoumarins, which are privileged structures with potential antitumoral activity. Herein, a new 3-substituted isocoumarin was synthesized from 2-iodo-3,5-dimethoxy-benzoic acid and oct-1-yne in a cross-coupling Sonogashira reaction followed by a copper iodide-catalyzed intramolecular cyclization as key step using MeOH/Et3N as the solvent system. The present study also evaluated the leukometry, phagocytic activity, genotoxic potential and cell death induction of three different doses (5 mg/kg, 10 mg/kg and 20 mg/kg) of this newly synthesized isocoumarin, alone and in combination with the commercial chemotherapeutic agents cyclophosphamide (100 mg/kg) and cisplatin (6 mg/kg) in male Swiss mice. The results suggest that the isocoumarin has genotoxicity and causes cell death. Noteworthy, this new compound can increase splenic phagocytosis and lymphocyte frequency, which are related to immunomodulatory activity. When combined with either cyclophosphamide or cisplatin, chemopreventive activity led to a reduction in the effects of both chemotherapeutic drugs. Thus, the new isocoumarin is not a candidate for chemotherapeutic adjuvant in treatments using cyclophosphamide or cisplatin. Nevertheless, the compound itself is an important prototype for the development of new antitumor drugs.

O objetivo do presente estudo foi identificar e comparar a qualidade de vida (QV) dos professores de educação física que atuam em academias de ginástica da cidade de Olinda-Pernambuco, de acordo com características sociodemográficas, econômicas e profissionais. Participaram do estudo 62 profissionais, sendo 58,1% homens. Os instrumentos de coleta de dados foram um questionário com questões sociodemográficas, comportamentais e econômicas, o Whoqol-Bref e o IPAQ. Foram encontradas diferenças significativas no domínio físico na faixa etária (p= 0,04) e nos ciclos de desenvolvimento profissional (p= 0,04); no domínio psicológico nas atividades exercidas na academia (p= 0,03); e no domínio ambiental no nível de atividade física no lazer (p= 0,01). Percebe-se que os professores de educação física de academias de ginástica apresentam uma QV relativamente boa, tendo em vista os elevados valores para os domínios da QV.

The aim of the present study was to identify and compare the quality of life (QoL) of physical education teachers who work in gyms in the city of Olinda, Pernambuco State, according to socio-demographic, economic and professional characteristics. This study included 62 professionals, 58.1% were men. Data collection instruments were a questionnaire addressing socio-demographic, behavioral and economic issues; the Whoqol-Bref and the IPAQ. Significant differences were detected: in the physical domain, in the age range (p= 0.04) and professional development cycles (p= 0.04); in the psychological domain, in the activities performed in the gym (p= 0.03); and in the environmental domain, at the level of the leisure physical activity (p= 0.01). The results suggested that physical education teachers of fitness centers in Olinda have a high quality of life, as seen by the elevated values of QoL domains.