Abstract The “International Group for Lean Construction” aims to adopt a new management philosophy for the Architecture, Engineering, and Construction (AEC) industry. Learning this philosophy can be supported by using active methodologies, especially serious games. This work aimed to analyse the evolution of using serious games as a teaching technique based on problem classes, in the context of the Lean Construction community. A literature review and an analysis of an empirical experience were carried out in an architecture and urbanism undergraduate course. The results demonstrate the evolution of the use of these techniques, as well as their implications for the education and training of AEC professionals. International Architecture Engineering (AEC industry methodologies classes community course techniques professionals

Resumo O “International Group for Lean Construction” busca adaptar à indústria de Arquitetura, Engenharia e Construção (AEC) uma nova filosofia gerencial. O aprendizado dessa filosofia pode ser apoiado pela utilização de metodologias ativas, especialmente dos jogos didáticos (do inglês “serious games”). Este trabalho teve como objetivo analisar a evolução da aplicação de jogos didáticos como técnica de aprendizagem baseada em classes de problemas, no contexto da comunidade da Construção Enxuta.Foi realizada uma revisão sistemática de literatura e a análise de uma experiência empírica, em uma disciplina de graduação de arquitetura e urbanismo. Os resultados demonstram a evolução do uso dessas técnicas, bem como suas implicações para a formação e treinamento de profissionais da AEC. International Construction Arquitetura AEC (AEC gerencial ativas serious games. games . games”) problemas EnxutaFoi Enxuta Foi empírica urbanismo técnicas games”

Abstract Objective To evaluate the growth trajectory of head circumference and neurodevelopment, and to correlate head circumference with cognitive, language, and motor outcomes during the first two years. Method Prospective cohort study in a tertiary hospital including 95 newborns under 32 weeks or 1500 g. Neonates who developed major neonatal morbidities were excluded. The head circumference was measured at birth, at discharge, and at term-equivalent age, 1, 3, 5, 12, 18, and 24 months of corrected age, and the Bayley Scales (Bayley-III) were applied at 12, 18 and 24 months of corrected age to assess cognitive, language and, motor domains. Scores below 85 were classified as mild/moderate deficits and scores below 70 as severe deficits. The association between head circumference Z score and Bayley scores was assessed using Pearson's correlation. The study considered a significance level of 0.05. Results There was a decrease of -0.18 in the head circumference Z score between birth and discharge and the catch-up occurred between discharge and 1 month (an increase of 0.81 in the Z score). There was a positive correlation between head circumference and Bayley scores at 18 months. There was also a positive correlation between head circumference at discharge and at 5 months with the three domains of the Bayley. Conclusion Serial measurements of head circumference provide knowledge of the trajectory of growth, with early catch-up between discharge and 1 month, as well as its association with neurodevelopment. Head circumference is therefore a valuable clinical marker for neurodevelopment, especially in very preterm newborns. neurodevelopment cognitive years 9 3 150 g excluded termequivalent term equivalent 12 2 BayleyIII III (Bayley-III 8 mildmoderate mild moderate 7 Pearsons Pearson s 005 0 05 0.05 0.18 018 -0.1 catchup catch up an 081 81 0.8 score. . score) 15 00 0.0 0.1 01 -0. 08 0. -0 -

Introdução: O ensino em cirurgia deve acompanhar a evolução das técnicas, procedimentos e tecnologia. Desde a década de 90 a videocirurgia vem se desenvolvendo e hoje é a primeira escolha para muitos procedimentos em cirugia geral. Com características diferentes da cirurgia convencional, os residentes treinaram em simuladores para adaptação. A literatura médica mundial já apresenta programas consagrados para treinamento entre eles os Fundamentos da Cirurgia Laparoscópica (FLS). A avaliação das habilidades técnicas cirúrgicas é uma ferramenta importante em programas de residência médica. Objetivo: Avaliar o impacto do treinamento através de aquisição de habilidades dos médicos residentes em cirurgia geral antes e após treinamento teórico-prático em videocirurgia utilizando um simulador de baixa fidelidade baseado em exercícios do FLS. Método: Estudar de modo prospectivo a aquisição de habilidades de médicos residentes em cirurgia geral de primeiro e segundo ano (R1 e R2), antes e após realização de treinamento teórico-prático pré-definido. Conclusão: Houve melhora significativa com o treinamento atingindo níveis de conhecimento e aprimoramento semelhantes aos trabalhos da literatura mundial. A melhoria no desempenho dos residentes foi evidente em ambos os grupos da amostra. Aqueles do primeiro ano atingiram a concentração de conhecimento após o treinamento semelhante ao desempenho dos residentes de segundo ano na avaliação inicial, destacando que o treinamento sequenciado realizado equivale a um ano de prática no programa de residência geral de cirurgia

Introduction: Teaching in surgery must follow the evolution of medical techniques, procedures and technology. Since the 90s videosurgery has been developing and nowadays is the gold standard for many procedures in general surgery. As there are different characteristics from conventional surgery, residents need to practice in order to adapt to simulators. The world medical literature has established many training programs among them the Fundaments of laparoscopic Surgery (FLS). Evaluation of surgical technical abilities is a major tool for the residency programs. Objectives: To assess the effect of training acquiring skills of residents at first and second postgraduated level year (PGY1 and PGY2) before and after practice using low fidelity simulator based on tasks from FLS. Methods: A prospective study was conducted to determinate skills acquisition of residents at first and second postgraduated level year l (PGY1 and PGY2) before and after standardized practice using low fidelity simulator. Conclusions: There was a significant improve of the technical abilities reaching levels of improvement. Resident’s performance was evident in the sample groups. First year residents (PGY1) achieved knowledge retention after training similar to the performance of second in the initial assessment, suggesting that the sequenced training carried out is equivalent to one year of practice in the general surgery residency program

Introduction: Surgical procedures were systematized and scientifically based at the end of the 19th century by William Stewart Halsted. Through scientific studies, anatomical principles, knowledge of physiology and pathology, strict aseptic techniques, gentle tissue manipulation, among others, were systematized. This lasted for centuries. But the modern technological era invented videosurgery and complicated the previously used teaching method. Objective: Review previously published teaching methods using simulators. Method: This is a narrative review carried out in the PubMed and Scielo databases. The search used the following keywords: videosurgery, teaching, simulators, training. The inclusion criteria comprised review articles and experimental studies, written in Portuguese and English and available in full text. The selected articles were analyzed based on the technologies covered, future perspectives and challenges mentioned. Result: 28 articles were included. Conclusion: As the results of this review on simulators show, once trained residents begin learning videolaparoscopic operations much more easily and safely.

Introdução: Os procedimentos cirúrgicos foram sistematizados e embasados cientificamente no final do século XIX por William Stewart Halsted. Por meio de estudos científicos, princípios anatômicos, conhecimento de fisiologia e patologia que permitiram sistematizar técnica asséptica estrita, manipulação tecidual gentil, dentro de outros. Isto perdurou por séculos. Mas a moderna era tecnológica inventou a videocirurgia e complicou o método de ensino anteriormente usado. Objetivo: Revisar os métodos de ensino feito por simuladores já publicados. Método: Trata-se de revisão narrativa realizada nas bases de dados PubMed e Scielo. A busca utilizou as seguintes palavras-chave: videocirurgia, ensino, simuladores, treinamento. Os critérios de inclusão compreenderam artigos de revisão e estudos experimentais, escritos em português e inglês e disponíveis em texto completo. Os trabalhos selecionados foram analisados com base nas tecnologias abordadas, perspectivas futuras e desafios mencionados. Resultado: Foram incluídos 28 artigos. Conclusão: Conforme mostram os resultados desta revisão sobre simuladores, os residentes depois de treinados, iniciariam o aprendizado de operações videolaparoscópicas com muito mais facilidade e segurança.

Introdução: O ensino em cirurgia convencional foi tradicionalmente baseado no modelo halstediano do “see one, do one and teach one” (veja um, faça um e ensine um); porém, com a bem sucedida propagação da cirurgia videolaparoscópica precisou ser adaptado para um novo modelo do “do many, mentored always” (fazer vários, sempre supervisionado). A nova era da cirurgia demanda treinamento sequencial, com crescente complexidade e repetição supervisionada para adquirir habilidades especificas prévias ao primeiro ato operatório. Objetivo: Desenvolver modelo para ensino e treinamento em videocirurgia com plataforma de baixo custo, fácil execução e baixa fidelidade com tarefas que utilizam materiais sintéticos. Método: Construiu-se com materiais de baixo custo plataforma utilizando apenas placa de madeira, poucos materiais de ferragem (parafuso simples, parafuso com porca tipo borboleta, gancho com rosca), folha de EVA (etileno acetato de vinila), tinta branca para artesanato e caneta hidrográfica. A amostra-teste foi composta por 15 cirurgiões gerais com mais de 10 anos de experiência em videolaparoscopia. Iniciou-se a avaliação com um vídeo explicativo com duração de 20 min. A seguir, cada cirurgião executou 5 tarefas gravadas para posterior análise e pontuação. Mediu-se as habilidades de acordo com a pontuação. Resultados: A plataforma foi útil e eficaz em reproduzir as atividades utilizadas para replicação do programa comparativo do Fundaments of Laparoscopic Surgery. A amostra de cirurgiões atingiu o tempo alvo definido como padrão pelo programa. Conclusão: A plataforma elaborada com materiais de baixo custo é de fácil aquisição, mostrou-se modelo eficaz para treinamento em videocirurgia, de fácil replicabilidade e construção, adaptável a vários modelos de tarefas, e feita com materiais sintéticos.

Introduction: Teaching in conventional surgery has traditionally been based on the Halstedian model of “see one, do one, and teach one”. However, with the widespread success of videolaparoscopic surgery, the teaching method needed to be adapted to a novel “Do many, always mentored” model. The modern era of surgery demands sequential training with progressively increasing complexity and supervised repetition, in order to acquire specific skills prior to the first surgical procedure. Objective: To develop a new experimental teaching and training with low cost and low fidelity platform for laparoscopic surgery using synthetic materials, and simple manufacturing. Method: A platform was built using low-cost materials easily found in hardware stores, consisting of a wooden board and a few hardware materials (threaded bolt, wing nut and bolt, threaded hooks), EVA sheet (ethylene vinylacetat), white crafting paint, and felt-tip pen. The sample consisted of 15 general surgeons with more than 10 years of experience in videolaparoscopy. The evaluation began with an explanatory video lasting 20 min. Next, each surgeon performed 5 recorded tasks for later analysis and scoring. Skills were measured according to the stablished score. Results: The developed platform was useful and capable of reproducing the tasks performed based on the program of Fundaments of Laparoscopic Surgery. All the surgeons of the sample group achieved the target time proposed for the program. Conclusion: Was shown that the proposed platform can be built using easily obtainable and low-cost materials, and it proved to be an effective model for training in laparoscopic surgery, being easy to replicate and construct. Additionally, this platform can be easily adapted to various models of tasks using materials similar to those found in other training programs, that are widely practiced and have been globally validated.

Abstract To date, hydroxyurea is the only effective and safe drug that significantly reduces morbidity and mortality of individuals with Sickle cell disease. Twenty years of real-life experience has demonstrated that hydroxyurea reduces pain attacks, vaso-occlusive events, including acute chest syndrome, the number and duration of hospitalizations and the need for transfusion. The therapeutic success of hydroxyurea is directly linked to access to the drug, the dose used and adherence to treatment which, in part, is correlated to the availability of hydroxyurea. This consensus aims to reduce the number of mandatory exams needed to access the drug, prioritizing the requesting physician's report, without affecting patient safety. date disease reallife real life attacks vasoocclusive vaso occlusive events syndrome transfusion which part physicians physician s report safety

Abstract Background: Methotrexate (MTX) is an alternative treatment for patients with moderate/severe atopic dermatitis (AD). Objective: The authors evaluated the effect of MTX on the cutaneous expression of cytokines and chemokines that are involved in the inflammatory response in adult AD patients who received treatment with methotrexate for 24 weeks. Methods: The authors conducted a prospective single-institution cohort study with 12 adults with moderate/severe AD who received oral MTX (15 mg/wk for 24 wks) and 10 non-atopic matched controls. The comparison was made of skin biopsies of lesional and non-lesional skin, pre- and post MTX treatment. The authors analyzed mean epidermal thickness and expression of IL-31, IL-31RA, OSMR, TSLP, Ki67, IL-4 mRNA, IL-6, IL-10, TNF-α, IFN-γ, TARC, and CCL-22. Results: There was a reduction in mean epidermal thickness (p = 0.021), an increase in IL-31RA expression (immunohistochemistry) in the epidermis (p = 0.016) and a decrease in IL-31 gene expression (p = 0.019) on lesional AD skin post-MTX treatment. No significant changes in the cutaneous expression of the other evaluated markers were identified. Study limitations: Small sample size and limited length of follow-up. Conclusions: Treatment with MTX in adults with moderate/severe AD reduced epidermal hyperplasia and changed the cutaneous expression of inflammatory cytokines and receptors that are mainly related to pruritus, including IL-31 and IL-31RA. Background (MTX moderatesevere moderate severe AD. . (AD) Objective 2 weeks Methods singleinstitution single institution 1 15 (1 mgwk mg wk wks nonatopic non controls nonlesional pre IL31, IL31 IL 31, 31 IL31RA, IL31RA ILRA 31RA, 31RA RA OSMR TSLP Ki67 Ki IL4 4 IL- mRNA IL6, IL6 6, 6 IL-6 IL10, IL10 10, IL-10 TNFα, TNFα TNF α, α TNF-α IFNγ, IFNγ IFN γ, γ IFN-γ TARC CCL22. CCL22 CCL 22. 22 CCL-22 Results p 0.021, 0021 0.021 , 0 021 0.021) immunohistochemistry (immunohistochemistry 0.016 0016 016 IL-3 0.019 0019 019 postMTX identified limitations followup. followup follow up. up follow-up Conclusions pruritus IL31RA. 31RA. (AD ( IL3 3 Ki6 IL1 IL-1 CCL2 CCL-2 002 0.02 02 0.01 001 01 CCL- 00 0.0 0.

Abstract This research paper focuses on the use of murumuru husk ash (MHA), an agro-industrial waste generated specifically in the Amazon region, as partial replacement of cement in structural concrete. It also evaluates the physical, chemical and mineralogical characteristics of the ash to act as filler in concrete and its properties in the fresh and hardened states in concrete. To this end, the MHA performed physical-mechanical characterization tests, such as specific mass, pozzolanic activity with Portland cement, pozzolanic activity with lime, and BET test, also performing the mineralogical and chemical analysis of the ash. The results showed that there is technical feasibility with partial replacement of 6% of MHA in cement using plasticizer additive to improve workability, thus showing an improvement in the physical-mechanical and durability properties of the concrete. MHA, , (MHA) agroindustrial agro industrial region physical end physicalmechanical mechanical tests mass lime test 6 workability (MHA

Resumo O estudo objetiva pesquisar o uso da cinza da casca do murumuru (CCM), um resíduo agroindustrial gerado especificamente na região amazônica como substituição parcial do cimento no concreto estrutural e avaliar as características físicas, químicas e mineralógicas da cinza para atuação como filler no concreto, além de suas propriedades no estado fresco e endurecido no concreto. Com esse intuito, o CCM passou pelos ensaios de caracterização físico-mecânicas como o de massa específica, atividade pozolânica com cimento Portland, atividade pozolânica com a cal e ensaio de BET, realizando-se também as análises mineralógicas e químicas da cinza. Os resultados mostraram que existe uma viabilidade técnica com substituição parcial de 6% de CCM no cimento, utilizando-se aditivo plastificante para melhorar a trabalhabilidade, mostrando uma melhora nas propriedades físico-mecânicas e de durabilidade do concreto. CCM, , (CCM) físicas intuito físicomecânicas físico mecânicas específica Portland BET realizandose realizando se 6 utilizandose utilizando trabalhabilidade (CCM

Objetivo: identificar factores asociados con la adherencia a la vacuna contra la COVID-19 durante el embarazo. Método: estudio transversal y analítico con 348 puérperas en alojamiento compartido en Maternidades Municipales de Recife-PE. Los datos fueron recolectados por medio de entrevistas durante los meses de junio a septiembre de 2022. Para el análisis estadístico se aplicaron las pruebas Chi-Cuadrado de Pearson o Exacta de Fisher y el modelo de regresión de Poisson. Resultados: el 17,2% de las gestantes cumplió con el esquema completo de vacunación, y la adherencia se asoció con el acceso a internet/televisión/radio (p-valor = 0,011), la vacunación prenatal de rutina (p-valor = 0,019), la seguridad con relación a la eficacia de la vacuna contra la COVID-19 y el apoyo de la pareja (p-valor = 0,020). Las mujeres puérperas sin acceso a internet/televisión/radio, y que se sienten seguras de la eficacia de la vacuna, tuvieron tasas de prevalencia más altas de adherencia a la vacunación contra la COVID-19, con RP de 2,56 y 3,25, respectivamente. Conclusión: se evidenció baja adherencia al esquema de vacunación contra la COVID-19 durante el período gestacional, considerándose el número de dosis recomendadas y el intervalo entre ellas. Por ello, los profesionales en su práctica clínica deben concienciar a las mujeres embarazadas sobre la importancia de la inmunización y del cumplimiento del esquema vacunal. Objetivo COVID19 COVID 19 COVID-1 embarazo Método 34 RecifePE. RecifePE Recife PE. PE Recife-PE 2022 ChiCuadrado Chi Cuadrado Poisson Resultados 172 17 2 17,2 internettelevisiónradio internet televisión radio pvalor p valor 0,011, 0011 0,011 , 0 011 0,011) 0,019, 0019 0,019 019 0,019) 0,020. 0020 0,020 . 020 0,020) COVID19, 19, 256 56 2,5 325 3 25 3,25 respectivamente Conclusión gestacional ellas ello vacunal COVID1 1 COVID- 202 17, 001 0,01 01 002 0,02 02 5 2, 32 3,2 20 00 0,0 3, 0,

Objective: to identify factors associated with adherence to the COVID-19 vaccine during pregnancy. Method: cross-sectional and analytical study with 348 postpartum women in shared accommodation at the Municipal Maternities of Recife-PE. Data was collected through interviews during the months of June to September 2022. Pearson’s Chi-Square or Fisher’s Exact tests and the Poisson regression model were applied for statistical analysis. Results: 17.2% of pregnant women adhered to the complete vaccination schedule, and adherence was associated with access to the internet/TV/radio (p-value = 0.011), routine prenatal vaccination (p-value = 0.019), safety of the efficacy of the COVID-19 vaccine and partner support (p-value = 0.020). Postpartum women without access to the internet/TV/radio, and who feel confident about the effectiveness of the vaccine, had higher prevalence rates for adhering to COVID-19 vaccination, with PRs of 2.56 and 3.25, respectively. Conclusion: there was evidence of low adherence to the vaccination schedule against COVID-19 during the gestational period, considering the number of recommended doses and the interval between them. Therefore, professionals in their clinical practice must make pregnant women aware of the importance of immunization and compliance with the vaccination schedule. Objective COVID19 COVID 19 COVID-1 pregnancy Method crosssectional cross sectional 34 RecifePE. RecifePE Recife PE. PE Recife-PE 2022 Pearsons Pearson s ChiSquare Chi Square Fishers Fisher analysis Results 172 17 2 17.2 internetTVradio internet TV radio pvalue p value 0.011, 0011 0.011 , 0 011 0.011) 0.019, 0019 0.019 019 0.019) 0.020. 0020 0.020 . 020 0.020) 256 56 2.5 325 3 25 3.25 respectively Conclusion period them Therefore COVID1 1 COVID- 202 17. 001 0.01 01 002 0.02 02 5 2. 32 3.2 20 00 0.0 3. 0.

Objetivo: identificar os fatores associados à adesão da vacina contra a covid-19 no período gestacional. Método: estudo transversal e analítico com 348 puérperas em alojamentos conjuntos das Maternidades Municipais de Recife-PE. Os dados foram coletados por meio de entrevistas durante os meses de junho a setembro de 2022. Aplicou-se para a análise estatística o teste Qui-Quadrado de Pearson ou Exato de Fisher e o modelo de regressão de Poisson. Resultados: 17,2% das gestantes aderiram ao esquema completo de vacinação, e a adesão estava associada ao acesso à internet/TV/rádio (p-valor = 0,011), à vacinação de rotina no pré-natal (p-valor = 0,019), à segurança da eficácia da vacina contra a covid-19 e ao apoio do companheiro/parceria (p-valor = 0,020). As puérperas sem acesso à internet/TV/rádio, e que se sentem seguras com relação à eficácia da vacina, apresentaram maiores prevalências para adesão à vacinação da COVID-19, com RP de 2,56 e 3,25, respectivamente. Conclusão: evidenciou-se uma baixa adesão ao esquema vacinal contra a covid-19 no período gestacional, considerando-se o número de doses recomendadas e o intervalo entre as mesmas. Dessa maneira, os profissionais em sua prática clínica devem conscientizar as gestantes da importância da imunização e do cumprimento do esquema vacinal. Objetivo covid19 covid 19 covid-1 gestacional Método 34 RecifePE. RecifePE Recife PE. PE Recife-PE 2022 Aplicouse Aplicou QuiQuadrado Qui Quadrado Poisson Resultados 172 17 2 17,2 internetTVrádio internet TV rádio pvalor p valor 0,011, 0011 0,011 , 0 011 0,011) prénatal pré natal 0,019, 0019 0,019 019 0,019) companheiroparceria companheiro parceria 0,020. 0020 0,020 . 020 0,020) COVID19, COVID19 COVID 19, COVID-19 256 56 2,5 325 3 25 3,25 respectivamente Conclusão evidenciouse evidenciou considerandose considerando mesmas maneira covid1 1 covid- 202 17, 001 0,01 01 002 0,02 02 COVID1 COVID-1 5 2, 32 3,2 20 00 0,0 COVID- 3, 0,

Abstract Introduction: Team-Based Learning (TBL) is an active methodology that has shown to be effective for the training of health professionals. In 2020, due to the COVID-19 pandemic, TBL utilization migrated from the in-person to the synchronous online mode. Objectives: This study aimed to evaluate the perception of health undergraduate students about online TBL and to analyze whether there is a difference regarding this perception between groups of students with different levels of exposure prior to in-person and online sessions of the teaching method, in addition to verifying whether such perception can be affected by the student’s behavioral profile. Method: This is an observational, cross-sectional, descriptive-exploratory level II comparative study with a quantitative approach, carried out in undergraduate Nursing and Medicine courses between September and December 2021. A questionnaire on sociodemographic data was applied virtually, in addition to the Assessment of Student Perception-Team-Based Learning (ASP-TBL) and the DISC Personality Test instruments. Results: Of the 241 participating students, most were females (81%), aged between 20.8 and 24.4 years, who had already attended more than 10 sessions of in-person TBL (90%) and online TBL (53%). Of the 24 ASP-TBL questions, 17 obtained an index equal to or greater than 75% in the sum of the answers “I totally agree”/“I agree”, values considered as a positive perception in this study. Students exposed to more than 10 online TBL sessions had a significantly more negative perception in three of the four dimensions of the ASP-TBL, when compared to less exposed students. The group that had participated in more than 10 in-person TBL sessions had a significantly more negative perception in only one dimension of the instrument, when compared to the less exposed ones. The main DISC Personality test factor found among the participants’ behavioral profiles was submission (“S”). There was no correlation between the student’s behavioral profile and their perception of the method in the online version. Conclusions: There was a favorable perception of health undergraduate students regarding online TBL. Previous prolonged exposure to the method, both online and in-person, represented a significant difference in the students’ perception of online TBL. There was no evidence of the influence of the student’s behavioral profile on their perception of the teaching method. Introduction TeamBased Team Based (TBL professionals 2020 COVID19 COVID 19 COVID-1 pandemic inperson person mode Objectives student s Method observational crosssectional, crosssectional cross sectional, sectional cross-sectional descriptiveexploratory descriptive exploratory approach 2021 virtually PerceptionTeamBased Perception ASPTBL ASP (ASP-TBL instruments Results 81%, 81 81% , (81%) 208 20 8 20. 244 4 24. years 1 90% 90 (90% 53%. 53 53% . (53%) 2 questions 75 I agree/I agreeI agree / agree, agree” ASPTBL, TBL, instrument ones participants S. S (“S”) version Conclusions inperson, person, 202 COVID1 COVID- (81% 9 (90 5 (53% 7 (“S” (81 (9 (53 (“S (8 ( (5

Resumo Introdução: O Team-Based Learning (TBL) é uma metodologia ativa que tem se mostrado efetiva para a formação de profissionais de saúde. Em 2020, devido à pandemia da Covid-19, a aplicação do TBL migrou da modalidade presencial para online síncrona. Objetivos: Este estudo objetivou avaliar a percepção de graduandos de saúde sobre o TBL online e analisar se existe diferença de percepção dessa modalidade entre os grupos de estudantes com níveis distintos de exposição anterior às sessões presenciais e online do método, além de verificar se tal percepção pode ser afetada pelo perfil comportamental do estudante. Método: Trata-se de um estudo observacional, transversal de caráter descritivo-exploratório, comparativo, relacional, de abordagem quantitativa, realizado nos cursos de graduação em Medicina e Enfermagem, entre setembro e dezembro de 2021. Aplicou-se, virtualmente, um questionário sobre os dados sociodemográficos, além dos instrumentos Avaliação da Percepção do Aluno-Team-Based Learning (APA-TBL) e Teste de Perfil Comportamental DISC. Resultados: Dos 241 estudantes participantes, houve predominância do sexo feminino (81%), na faixa etária de 20,8 a 24,4 anos, que já tinham frequentado mais de 10 sessões de TBL presencial (90%) e TBL online (53%). Das 24 questões do APA-TBL, 17 obtiveram índice igual ou superior a 75% na soma das respostas “concordo totalmente”/“concordo”, valores considerados como percepção positiva neste estudo. Os alunos com exposição a mais de 10 sessões do TBL online apresentaram uma percepção significativamente mais negativa em três das quatro dimensões do APA-TBL, quando comparados aos menos expostos. O grupo que havia participado de mais de 10 sessões de TBL presencial apresentou uma percepção significativamente mais negativa em apenas uma dimensão do instrumento, quando comparados aos menos expostos. O principal fator DISC encontrado entre os perfis comportamentais dos participantes foi a estabilidade (“S”). Não houve correlação entre o perfil comportamental do aluno e sua percepção sobre o método na versão online. Conclusões: Observou-se uma percepção favorável dos graduandos de saúde sobre o TBL online. A exposição anterior prolongada ao método, tanto no modo online, quanto presencial, impactou negativamente a percepção dos estudantes sobre o TBL online. Não foi evidenciada influência do perfil comportamental do estudante em sua percepção do método. Introdução TeamBased Team Based (TBL 2020 Covid19, Covid19 Covid 19, 19 Covid-19 síncrona Objetivos Método Tratase Trata observacional descritivoexploratório, descritivoexploratório descritivo exploratório, exploratório descritivo-exploratório comparativo relacional quantitativa Enfermagem 2021 Aplicouse, Aplicouse Aplicou se, Aplicou-se virtualmente sociodemográficos AlunoTeamBased Aluno APATBL APA (APA-TBL Resultados 81%, 81 81% , (81%) 208 20 8 20, 244 4 24, anos 1 90% 90 (90% 53%. 53 53% . (53%) 2 APATBL, TBL, APA-TBL 75 concordo totalmente/concordo, totalmenteconcordo totalmente / totalmente”/“concordo” expostos instrumento S. S (“S”) Conclusões Observouse Observou 202 Covid1 Covid-1 (81% 9 (90 5 (53% 7 totalmente/concordo totalmente”/“concordo (“S” Covid- (81 (9 (53 (“S (8 ( (5

ABSTRACT. The aim of this study was to examine the effect of longer cutting intervals on morphogenetic and structural traits, herbage production, nutritional value, and in vitro digestibility of Guinea grass cv. Mombaça (Mombaça grass). Four cutting intervals (49, 63, 77, and 91 days) were evaluated in two crop years (2015-2016 and 2016-2017) during the rainy season, in two replicates. Cutting intervals influenced structural and morphogenetic traits, except for number of live leaves (4.35 leaves tiller-1) and final leaf length (72.94 cm) in the 2015-2016 crop year. As the cutting intervals increased, dry matter yield and stem percentage increased, whereas leaf percentage and leaf-to-stem ratio declined. Regardless of the evaluated crop year, the dry matter, acid detergent fiber, and lignin contents increased linearly; however, the neutral detergent fiber content was unaffected. Cutting intervals affected the crude protein content and in vitro digestibility. Considering leaf appearance rate, stem appearance rate, and leaf-to-stem ratio, the recommended harvest age for Mombaça grass for optimum yield and nutritional value is 77 days. ABSTRACT traits production cv grass. . grass) 49, 49 (49 63 9 days 20152016 2015 2016 (2015-201 20162017 2017 2016-2017 season replicates 4.35 435 4 35 (4.3 tiller1 tiller 1 tiller-1 72.94 7294 72 94 (72.9 cm 2015-201 year leaftostem declined linearly however unaffected rate 7 (4 6 2015201 201 (2015-20 2016201 2016-201 4.3 43 3 (4. tiller- 72.9 729 (72. 2015-20 ( 201520 20 (2015-2 201620 2016-20 4. 72. (72 2015-2 20152 2 (2015- 20162 2016-2 (7 2015- (2015 2016- (201 (20 (2

ABSTRACT BACKGROUND: The prevalence of chronic kidney disease (CKD) has increased in the recent decades, along with the number of patients in the terminal stages of this disease, requiring transplantation. Some skin disorders are more frequent in patients with CKD and in renal transplant recipients (RTR). OBJECTIVES: To evaluate the frequency of skin diseases in RTR and patients with CKD receiving conservative treatment. DESIGN AND SETTING: This observational cross-sectional study recruited consecutive patients with CKD and RTR from a nephrology clinic at a teaching hospital in Brazil between 2015 and 2020. METHODS: Quantitative, descriptive, and analytical approaches were used. The sample was selected based on convenience sampling. Data were collected from dermatological visits and participants’ medical records. RESULTS: Overall, 308 participants were included: 206 RTR (66.9%, median age: 48 years, interquartile range [IQR] 38.0–56.0, 63.6% men) and 102 patients with CKD (33.1%, median age: 61.0 years, IQR 50.0–71.2, 48% men). The frequency of infectious skin diseases (39.3% vs. 21.6% P = 0.002) were higher in RTR than in patients with CKD. Neoplastic skin lesions were present in nine (4.4%) RTR and in only one (1.0%) patient with CKD. Among the RTR, the ratio of basal cell carcinoma to squamous cell carcinoma was 2:1. CONCLUSIONS: This study revealed that an increased frequency of infectious skin diseases may be expected in patients who have undergone kidney transplantation. Among skin cancers, BCC is more frequently observed in RTR, especially in those using azathioprine. BACKGROUND (CKD decades transplantation RTR. . (RTR) OBJECTIVES treatment SETTING crosssectional cross sectional 201 2020 METHODS Quantitative descriptive used sampling records RESULTS Overall 30 included 20 66.9%, 669 66 9 (66.9% age 4 years [IQR 380560 38 0 56 38.0–56.0 636 63 6 63.6 men 10 33.1%, 331 33 1 (33.1% 610 61 61. 500712 50 71 2 50.0–71.2 men. 39.3% 393 39 3 (39.3 vs 216 21 21.6 0.002 0002 002 4.4% 44 (4.4% 1.0% (1.0% 21. 1. 2:1 CONCLUSIONS cancers azathioprine (RTR 202 66.9% (66.9 38056 5 38.0–56. 63. 33.1% (33.1 50071 7 50.0–71. 39.3 (39. 0.00 000 00 4.4 (4.4 1.0 (1.0 2: 66.9 (66. 3805 38.0–56 33.1 (33. 5007 50.0–71 39. (39 0.0 4. (4. (1. 66. (66 380 38.0–5 33. (33 500 50.0–7 (3 0. (4 (1 (6 38.0– 50.0– ( 38.0 50.0 38. 50.

Abstract Background Increased malignancy frequency is well documented in adult-systemic lupus erythematosus (SLE), but with limited reports in childhood-onset SLE (cSLE) series. We explored the frequency of malignancy associated with cSLE, describing clinical and demographic characteristics, disease activity and cumulative damage, by the time of malignancy diagnosis. Method A retrospective case-notes review, in a nationwide cohort from 27 Pediatric Rheumatology centres, with descriptive biopsy-proven malignancy, disease activity/damage accrual, and immunosuppressive treatment were compiled in each participating centre, using a standard protocol. Results Of the 1757 cSLE cases in the updated cohort, 12 (0.7%) developed malignancy with median time 10 years after cSLE diagnosis. There were 91% females, median age at cSLE diagnosis 12 years, median age at malignancy diagnosis 23 years. Of all diagnosed malignancies, 11 were single-site, and a single case with concomitant multiple sites; four had haematological (0.22%) and 8 solid malignancy (0.45%). Median (min–max) SLEDAI-2 K scores were 9 (0–38), median (min–max) SLICC/ACR-DI (SDI) score were 1 (1–5) Histopathology defined 1 Hodgkin's lymphoma, 2 non-Hodgkin's lymphoma, 1 acute lymphoblastic leukaemia; 4 gastrointestinal carcinoma, 1 squamous cell carcinoma of the tongue and 1 anal carcinoma; 1 had sigmoid adenocarcinoma and 1 stomach carcinoid; 3 had genital malignancy, being 1 vulvae, 1 cervix and 1 vulvae and cervix carcinomas; 1 had central nervous system oligodendroglioma; and 1 testicle germ cell teratoma. Conclusion Estimated malignancy frequency of 0.7% was reported during cSLE follow up in a multicentric series. Median disease activity and cumulative damage scores, by the time of malignancy diagnoses, were high; considering that reported in adult series. adultsystemic systemic SLE, , (SLE) childhoodonset childhood onset (cSLE series characteristics casenotes notes review centres biopsyproven biopsy proven activitydamage accrual centre protocol 175 07 0 7 (0.7% 91 females malignancies singlesite, singlesite site, site single-site sites 0.22% 022 22 (0.22% 0.45%. 045 0.45% . 45 (0.45%) min–max minmax min max (min–max SLEDAI2 SLEDAI SLEDAI- 0–38, 038 0–38 38 (0–38) SLICC/ACRDI SLICCACRDI SLICC/ACR DI SLICC ACR SDI (SDI 1–5 15 5 (1–5 Hodgkins Hodgkin s lymphoma nonHodgkins non leukaemia carcinoid carcinomas oligodendroglioma teratoma 0.7 diagnoses high (SLE 17 (0.7 0.22 02 (0.22 04 0.45 (0.45% 03 0–3 (0–38 ACRDI SLICCACR 1– (1– 0. (0. 0.2 (0.2 0.4 (0.45 0– (0–3 (1 (0 (0.4 (0– (

ABSTRACT Although lung cancer (LC) is one of the most common and lethal tumors, only 15% of patients are diagnosed at an early stage. Smoking is still responsible for more than 85% of cases. Lung cancer screening (LCS) with low-dose CT (LDCT) reduces LC-related mortality by 20%, and that reduction reaches 38% when LCS by LDCT is combined with smoking cessation. In the last decade, a number of countries have adopted population-based LCS as a public health recommendation. Albeit still incipient, discussion on this topic in Brazil is becoming increasingly broad and necessary. With the aim of increasing knowledge and stimulating debate on LCS, the Brazilian Society of Thoracic Surgery, the Brazilian Thoracic Association, and the Brazilian College of Radiology and Diagnostic Imaging convened a panel of experts to prepare recommendations for LCS in Brazil. The recommendations presented here were based on a narrative review of the literature, with an emphasis on large population-based studies, systematic reviews, and the recommendations of international guidelines, and were developed after extensive discussion by the panel of experts. The following topics were reviewed: reasons for screening; general considerations about smoking; epidemiology of LC; eligibility criteria; incidental findings; granulomatous lesions; probabilistic models; minimum requirements for LDCT; volumetric acquisition; risks of screening; minimum structure and role of the multidisciplinary team; practice according to the Lung CT Screening Reporting and Data System; costs versus benefits of screening; and future perspectives for LCS. LC (LC tumors 15 stage 85 cases (LCS lowdose low dose (LDCT LCrelated related 20 20% 38 cessation decade populationbased population recommendation incipient necessary Surgery Association literature studies reviews guidelines reviewed criteria findings lesions models acquisition team System 1 8 2 3

RESUMO O câncer de pulmão (CP) é uma das neoplasias mais comuns e letais no Brasil, e apenas 15% dos pacientes são diagnosticados nos estágios iniciais. O tabagismo persiste como o responsável por mais de 85% de todos os casos. O rastreamento do CP (RCP) por meio da TC de baixa dosagem de radiação (TCBD) reduz a mortalidade do CP em 20%, e, quando combinado com a cessação do tabagismo, essa redução chega a 38%. Na última década, diversos países adotaram o RCP como recomendação de saúde populacional. No Brasil, embora ainda incipiente, a discussão sobre o tema é cada vez mais ampla e necessária. Com o intuito de aumentar o conhecimento e estimular o debate sobre o RCP, a Sociedade Brasileira de Cirurgia Torácica, a Sociedade Brasileira de Pneumologia e Tisiologia e o Colégio Brasileiro de Radiologia e Diagnóstico por Imagem constituíram um painel de especialistas para elaborar as recomendações para o RCP. As recomendações aqui apresentadas foram baseadas em revisão narrativa da literatura, com ênfase em grandes estudos populacionais, em revisões sistemáticas e em recomendações de diretrizes internacionais, sendo construídas após ampla discussão pelo grupo de especialistas. Os temas revisados foram os seguintes: porque rastrear, considerações gerais sobre tabagismo, epidemiologia do CP, critérios de elegibilidade, achados incidentais, lesões granulomatosas, modelos probabilísticos, requisitos mínimos da TCBD, aquisições volumétricas, riscos do rastreamento, estrutura mínima e papel da equipe multidisciplinar, conduta segundo o Lung CT Screening Reporting and Data System (Lung-RADS), custos vs. benefícios e perspectivas do rastreamento. (CP Brasil 15 iniciais 85 casos (RCP TCBD (TCBD 20 20% 38 38% década populacional incipiente necessária Torácica literatura populacionais internacionais seguintes rastrear elegibilidade incidentais granulomatosas probabilísticos volumétricas multidisciplinar LungRADS, LungRADS RADS , (Lung-RADS) vs 1 8 2 3 (Lung-RADS

Abstract FioAntar, FIOCRUZ’s research project in Antarctica, is based on the One Health approach. FioAntar aims to generate relevant information that will help reduce the risk of future pandemics and improve the search for chemical compounds and new biological molecules. After four expeditions to Antarctica under the scope of PROANTAR, Fiocruz has identified Influenza H11N2 virus in environmental fecal samples, as well as Histoplasma capsulatum and Bacillus cereus in soil samples. In addition, in a prospective virome analysis from different lakes in the South Shetland Islands, six viral orders were described, supporting future research related to the biodiversity and viral ecology in this extreme ecosystem. Our findings of environmental pathogens of public health importance are a warning about the urgency of establishing a surveillance agenda on zoonoses in Antarctica due to the imminent risks that ongoing environmental and climate changes impose on human health across the planet. FioAntar strives to establish a comprehensive surveillance program across Antarctica, monitoring circulation of pathogens with the potential to transcend continent boundaries, thereby mitigating potential spread. For Fiocruz, Antarctica signifies a new frontier, teeming with opportunities to explore novel techniques, refine established methodologies, and cultivate invaluable knowledge. FIOCRUZs FIOCRUZ s approach molecules PROANTAR HN H N H11N samples addition Islands described ecosystem planet boundaries spread frontier techniques methodologies knowledge