ABSTRACT Purpose: To assess Meibomian gland dysfunction using meibography in patients with xeroderma pigmentosum and correlate with ocular surface changes. Methods: This cross-sectional study evaluated patients with xeroderma pigmentosum. All patients underwent a comprehensive and standardized interview. The best-corrected visual acuity of each eye was determined. Detailed ophthalmic examination was conducted, including biomicroscopy examination of the ocular surface, Schirmer test type I, and meibography, and fundus examination was also performed when possible. Meibomian gland dysfunction was assessed by non-contact meibography using Oculus Keratograph® 5M (OCULUS Inc., Arlington, WA, USA). Saliva samples were collected using the Oragene DNA Self-collection kit (DNA Genotek Inc., Ottawa, Canada), and DNA was extracted as recommended by the manufacturer. Factors associated with abnormal meiboscores were assessed using generalized estimating equation models. Results: A total of 42 participants were enrolled, and 27 patients underwent meibography. The meiboscore was abnormal in the upper eyelid in 8 (29.6%) patients and in the lower eyelid in 17 (62.9%). The likelihood of having abnormal meiboscores in the lower eyelid was 16.3 times greater than that in the upper eyelid. In the final multivariate model, age (p=0.001), mutation profile (p=0.006), and presence of ocular surface malignant tumor (OSMT) (p=0.014) remained significant for abnormal meiboscores. For a 1-year increase in age, the likelihood of abnormal meiboscores increased by 12%. Eyes with OSMT were 58.8 times more likely to have abnormal meiboscores than eyes without ocular surface malignant tumor. Conclusion: In the final model, age, xeroderma pigmentosum profile, previous cancer, and clinical alterations on the eyelid correlated with a meiboscore of ≥2. Meibomian gland dysfunction was common in patients with xeroderma pigmentosum, mainly in the lower eyelid. The severity of Meibomian gland dysfunction increases with age and is associated with severe eyelid changes. Purpose changes Methods crosssectional cross sectional interview bestcorrected best corrected determined conducted I possible noncontact non contact Keratograph M OCULUS Inc Inc. Arlington WA USA. USA . USA) Selfcollection Self collection Ottawa Canada, Canada , Canada) manufacturer models Results 4 enrolled 2 29.6% 296 29 6 (29.6% 1 62.9%. 629 62.9% 62 9 (62.9%) 163 16 3 16. model p=0.001, p0001 p p=0.001 0 001 (p=0.001) p=0.006, p0006 p=0.006 006 (p=0.006) (OSMT p=0.014 p0014 014 (p=0.014 1year year 12 12% 588 58 58. Conclusion cancer ≥2 29.6 (29.6 62.9 (62.9% p000 p=0.00 00 (p=0.001 (p=0.006 p=0.01 p001 01 (p=0.01 5 ≥ 29. (29. 62. (62.9 p00 p=0.0 (p=0.00 (p=0.0 (29 (62. p0 p=0. (p=0. (2 (62 p=0 (p=0 ( (6 p= (p= (p

Resumen El objetivo del estudio fue analizar cómo representantes de Organizaciones No Gubernamentales (ONG) de colectivos LGBT perciben las estrategias de inclusión de la prueba rápida para VIH/aids, sífilis y hepatitis virales en la escena LGBT de Porto Alegre. Fue un estudio cualitativo en el cual se entrevistaron 4 representantes de ONG de colectivos LGBT de la ciudad y analizadas mediante análisis crítico del discurso. Los resultados indican una preocupación de los entrevistados con las estrategias de cuidado que se construyen con la prueba y que tanto se relacionan con perespectivas de derechos humanos. Así, se construye una tensión que tienen como telón de fondo relaciones entre Estado, movimientos LGBT y VIH. Ignorar cuestiones políticas que permean estas relaciones despolitiza una historia en la que los mayores avances en términos de prevención y enfrentamiento de VIH pasaron por una respuesta conjunta entre diferentes actores sociales. Construir nuevos espacios de discusión puede propiciar que nuevas estrategias colectivas sean pensadas en el enfrentamiento de la epidemia, del prejuicio y del estigma.

Abstract This study was aim to analyze how representatives of LGBT NGOs perceive strategies about the inclusion of the rapid test for HIV/aids, syphilis and viral hepatitis in the LGBT scenario of Porto Alegre. It is a qualitative study in which 4 representatives were interviewed, and the interviews were analyzed through a critical analysis of discourse. The results point to a concern of the interviewees with the care strategies that are built with the test and how much they dialogue with human rights. This leads to tensions that have as a background the relations between State, LGBT movements and HIV. Ignoring political issues that permeate these relations depoliticizes a history in which the greatest advances in terms of prevention and confrontation have gone through a united response between different social actors. Building new spaces for discussion can allow new collective strategies to be considered in coping with the epidemic, prejudice and stigma.

Resumo O objetivo do estudo é analisar como representantes de ONGs LGBT percebem as estratégias de inclusão do teste rápido para HIV/aids, sífilis e hepatites virais na cena LGBT de Porto Alegre. Trata-se de um estudo qualitativo no qual foram entrevistados 4 representantes de ONGs LGBT da cidade, analisadas mediante análise crítica do discurso. Os resultados apontam para uma preocupação dos entrevistados com as estratégias de cuidado que se constroem com o teste e o quanto elas dialogam perespectivas de direitos humanos. Assim se constroem tensionamentos que tem como pano de fundo relações entre Estado, movimentos LGBT e HIV. Ignorar questões políticas que permeiam estas relações despolitiza uma história na qual os maiores avanços em termos de prevenção e enfrentamento passaram por uma resposta conjunta entre diferentes atores sociais. Construir novos espaços de discussão pode propiciar que novas estratégias coletivas sejam pensadas no enfrentamento da epidemia, do preconceito e do estigma.

RESUMO O objetivo deste estudo é compreender como o espaço digital permite a construção de narrativas de si para adolescentes, evidenciando novas estratégias de sociabilidade contemporâneas, a partir de uma aproximação teórica bakhtiniana. Trata-se de uma investigação exploratória e de inspiração etnográfica. Os participantes da pesquisa foram seis pessoas, com idade entre 16 e 18 anos. O processo de pesquisa ocorreu através da observação das movimentações no Facebook e entrevista individual. A análise partiu das narrativas e da produção discursiva dos adolescentes, organizada nos eixos: economia e estratégias de comunicação; relações de pertencimento e filiação; e autoria e autenticidade na construção de narrativas. As interações e identificações dos adolescentes no contexto digital ocorreram dialogicamente, articulando relações de pertencimento, autoria e autenticidade.

ABSTRACT The proposal of this study is to understand how the digital environment allowed the construction of narratives of themselves for adolescents, evidencing new strategies of contemporary sociability, based on the Bakhtinian theoretical approach. This is an exploratory and ethnographic-inspired investigation. The participants were six adolescents, between 16 and 18 years old. The research process was built through the observation of the movements on Facebook and subsequent individual interviews. The analysis was based on narratives and the discursive production of adolescents, organized in the axes: economy and communication strategies; relations of belonging and affiliation; and authorship and authenticity in the construction of the narratives. The interactions and identifications of the adolescents in the digital context occurred dialogically, articulating relations of belonging, authorship and authenticity.

RESUMEN El objetivo del presente estudio fue comprender cómo el espacio digital permitió la construcción de narrativas de sí para adolescentes, evidenciando nuevas estrategias de sociabilidad contemporáneas, a partir de una aproximación teórica bakhtiniana. Esta es una investigación exploratoria y de inspiración etnográfica. Los participantes de la investigación eran seis jóvenes, con edades comprendidas entre los 16 y 18 años. El proceso de investigación se llevó a cabo mediante la observación de los movimientos en Facebook y entrevistas individuales. El análisis partió de las narrativas y de la producción discursiva de los adolescentes, organizada en los ejes: economía y estrategias de comunicación; relaciones de pertenencia y filiación; y autoría y autenticidad en la construcción de narrativas. Las interacciones e identificaciones de los adolescentes en el contexto digital, ocurrieron dialogicamente, articulando relaciones de pertenencia, autoría y autenticidad.