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SUMMARY OBJECTIVE: Our study aimed to evaluate the correlation of cardiac troponin T levels with comorbidities and in-hospital outcomes in patients with coronavirus disease-2019 in Brazil. METHODS: Data from a cohort of 3,596 patients who were admitted with suspected coronavirus disease-2019 in a Brazilian tertiary center, between March and August 2020, were reviewed. A total of 2,441 (68%) patients had cardiac troponin T determined in the first 72 h of admission and were stratified into two groups: elevated cardiac troponin T (cardiac troponin T >0.014 ng/mL) and normal cardiac troponin T. Associations between troponin, comorbidities, biomarkers, and outcomes were assessed. Regression models were built to assess the association of several variables with in-hospital mortality. RESULTS: A total of 2,441 patients were embraced, of which 924 (38%) had normal cardiac troponin T and 1,517 (62%) had elevated cardiac troponin T. Patients with elevated cardiac troponin T were older and had more comorbidities, such as cardiovascular disease, hypertension, diabetes, arrhythmia, renal dysfunction, liver disease, stroke, cancer, and dementia. Patients with abnormal cardiac troponin T also had more altered laboratory parameters on admission (i.e., leukocytes, C-reactive protein, D-dimer, and B-type natriuretic peptide), as well as more need for intensive care unit, vasoactive drugs, mechanical ventilation, dialysis, and blood transfusion. All-cause mortality was markedly higher among patients with increased cardiac troponin T (42 vs. 16%, P<0.001). Multiple regression analysis demonstrated that in-hospital mortality was not independently associated with troponin elevation. CONCLUSION: This study showed that cardiac troponin T elevation at admission was common and associated with several comorbidities, biomarkers, and clinical outcomes in patients hospitalized with coronavirus disease-2019, but it was not an independent marker of in-hospital mortality. OBJECTIVE inhospital hospital disease2019 disease 2019 disease-201 Brazil METHODS 3596 3 596 3,59 center 2020 reviewed 2441 2 441 2,44 68% 68 (68% 7 groups 0014 0 014 >0.01 ng/mL ngmL ng mL biomarkers assessed RESULTS embraced 92 38% 38 (38% 1517 1 517 1,51 62% 62 (62% hypertension diabetes arrhythmia dysfunction stroke cancer dementia i.e., ie i e (i.e. leukocytes Creactive C reactive protein Ddimer, Ddimer D dimer, dimer D-dimer Btype B type peptide, peptide , peptide) unit drugs ventilation dialysis transfusion Allcause All cause 42 (4 vs 16 16% P<0.001. P0001 P P<0.001 . 001 P<0.001) CONCLUSION disease2019, 2019, disease201 201 disease-20 359 59 3,5 202 244 44 2,4 6 (68 01 >0.0 9 (38 151 51 1,5 (62 i.e. (i.e 4 ( P000 P<0.00 00 disease20 20 disease-2 35 5 3, 24 2, (6 >0. (3 15 1, i.e P00 P<0.0 disease2 disease- >0 P0 P<0. > P<0 P<