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Short curing time bulk fill composite systems: volumetric shrinkage, degree of conversion and Vickers hardness systems shrinkage
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SAMPAIO, Camila Sobral

; ABREU, João Luiz Bittencourt de

; KORNFELD, Batsheva

; SILVA, Eduardo Moreira da

; GIANNINI, Marcelo

; HIRATA, Ronaldo

Brazilian Oral Research

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2024, Volume 38 elocation e030

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to evaluate volumetric polymerization shrinkage, degree of conversion and Vickers hardness of four bulk-fill resin composites light-activated with their dedicated light curing units (LCUs). Four groups were evaluated, according to the type of composite and curing mode: Tetric EvoCeram Bulk-fill (TEBO) and Tetric EvoFlow Bulk-fill (TEBF) were light-activated with Bluephase Style 20i (20s, in high-mode), while Tetric Powerfill (TEPO) and Tetric Powerflow (TEPF) were light-activated with Bluephase PowerCure (3s). Volumetric polymerization shrinkage test (n = 6) was performed in standardized box-shaped class-I cavities of extracted third molars (4 x 4 x 4 mm). Teeth were scanned before and after resin composite application by micro-computed tomography, and acquired data were evaluated with Amira software. Degree of conversion (n = 5) was evaluated at the top and bottom surfaces of composite cylindric samples (4 mm diameter, 4 mm thickness) using an FT-IR spectrometer (spectra between 1,500 and 1,800 cm-1, 40 scans at a resolution of 4 cm-1). Three Vickers indentations (50 g / 15 s), spaced 500 μm apart, were performed on the top and bottom composite surfaces and averaged. One-way ANOVA was used for data evaluation. TEPF showed the lowest volumetric polymerization shrinkage (p < 0.05), while the other composites were not significantly different within each other (p > 0.05). All materials presented a significant decrease in degree of conversion and Vickers hardness when compared top to bottom surfaces (p < 0.05). Bottom to top surface ratios for degree of conversion ranged from 0.8 (TEBO and TEPO) to 0.9 (TEBF and TEPF), and from 0.4 (TEPO) to 0.7 (TEBF and TEPF) for hardness. In conclusion, resinous materials present a decrease in hardness and degree of conversion from top to bottom even when a higher power is used, while the flowable material TEPF showed the lowest volumetric shrinkage values compared to the other materials. bulkfill bulk fill lightactivated activated LCUs. LCUs . (LCUs) mode Bulkfill Bulk TEBO TEBF i 20s, 20s s (20s highmode, highmode high , high-mode) TEPO (TEPO (TEPF 3s. 3s (3s) n 6 boxshaped box shaped classI class I ( mm. mm) microcomputed micro computed tomography software 5 diameter thickness FTIR FT IR spectra 1500 1 1,50 1800 800 1,80 cm1, cm1 cm 1, cm-1 cm1. cm-1) 50 (5 s, s) apart averaged Oneway One way evaluation p 0.05, 005 0.05 0 05 0.05) 0.05. 08 8 0. 09 9 TEPF, 04 07 7 conclusion (LCUs high-mode (3s 150 1,5 180 80 1,8 cm- 00 0.0 18

https://doi.org/10.1590/1807-3107bor-2024.vol38.0030

Roughness profile and surface roughness after toothbrushing and degree of conversion of bulk-fill resins bulkfill bulk fill
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TERADA, Raquel Sano Suga

; FRONZA, Bruna Marin

; FARAONI, Juliana Jendiroba

; HOSHINO, Lidiane Vizioli de Castro

; SATO, Francielle

; PALMA-DIBB, Regina Guenka

; SCHEFFEL, Debora Lopes Salles

; GIANNINI, Marcelo

Brazilian Oral Research

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2024, Volume 38 elocation e128

Resumo: En | Texto: En | PDF: En

Abstract The aim of this study was to assess roughness profile and surface roughness after simulated toothbrushing cycles, as well as the degree of conversion (DC) of bulk-fill resin composites at different depths. Forty nine composite discs were made from three low-viscosity bulk-fill resins (Filtek Bulk-Fill Flowable/3M Oral Care - FBF, Beautifil-Bulk Flowable/Shofu Inc. - BBF and Surefill SDR Flow/Dentsply Caulk - SDR), three high-viscosity bulk-fill resin composites (Filtek Bulk-Fill Restorative/3M Oral Care - FBR, Beautifil-Bulk Restorative/Shofu Inc. - BBR and Tetric EvoCeram Bulk Fill/Ivoclar Vivadent - TEB) and one conventional composite (Filtek Supreme Ultra/3M Oral Care - FSU) (n=7), using addition silicon molds (2 mm thick x 10 mm diameter). The roughness profile (Rv) and surface roughness (Sa) were analyzed after 30,000 brushing cycles using confocal laser scanning microscopy. Five samples (4 mm thick x 2 mm diameter) were produced per resin composite and light-cured for 20 seconds using a LED-curing unit. After 24 hours at 37oC, DC of samples was evaluated at four depths, using a confocal Raman microscope. The data were analyzed by ANOVA and Tukey post hoc multiple-comparison tests (α = 0.05). The Rv values of FSU were lower than those obtained for BBR and BBF. The toothbrushing significantly decreased the Sa for all composites. The DC was significantly reduced at 4 mm depth. Toothbrushing changed composite surface of all materials, especially for BBR and BBF. Composites were not able to maintain the DC values shown at the top compared with those at the bottom (4 mm depth). (DC bulkfill bulk fill depths lowviscosity low viscosity Filtek BulkFill Fill Flowable3M FlowableM Flowable 3M M FBF BeautifilBulk Beautifil FlowableShofu Shofu Inc FlowDentsply Flow Dentsply SDR, , SDR) highviscosity high Restorative3M RestorativeM Restorative FBR RestorativeShofu FillIvoclar Ivoclar TEB Ultra3M UltraM Ultra n=7, n7 n n=7 7 (n=7) ( 1 diameter. diameter . (Rv (Sa 30000 30 000 30,00 microscopy lightcured light cured LEDcuring LED curing unit 37oC oC microscope multiplecomparison multiple comparison α 0.05. 005 0.05 0 05 0.05) depth materials depth) n= (n=7 3000 3 00 30,0 0.0 (n= 300 30, 0. (n

https://doi.org/10.1590/1807-3107bor-2024.vol38.0128

Effect of argon plasma and dentin rehydration on bond strength of dental adhesives to etched dentin
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Santos, Daniela Bandeira dos

; Araújo Neto, Vitaliano Gomes de

; Willers, Amanda Endres

; André, Carolina Bosso

; Giannini, Marcelo

Brazilian Dental Journal

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2024, Volume 35 elocation e24-6029

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este estudo investigou os efeitos da aplicação de plasma não térmico à pressão atmosférica (PLAR) e da reidratação dentinária com água (REID) na resistência de união (RU) de adesivos. Foram testados três adesivos convencionais: Scotchbond Multi-Purpose (SBM / primer à base de água + resina adesiva), Gluma Bond Universal (GBU / frasco único contendo acetona como solvente orgânico) e Prime&Bond Universal (PBU / frasco único contendo propanol como solvente orgânico). Os adesivos foram aplicados: 1- na dentina condicionada com ácido fosfórico (Controle), 2- após aplicação de PLAR por 45 segundos na dentina condicionada ou 3- após REID com água (10 segundos) na dentina condicionada tratada com plasma. A RU foi realizada utilizando molares humanos e teste de microtração, em que as amostras foram testadas após 24 horas ou um ano (n=6). Os dados de RU foram analisados por ANOVA mista de três fatores e teste de Bonferroni (α=0,05). A morfologia da dentina condicionada (n=3) e as interfaces dentina-adesivo (n=3) foram avaliadas por MEV. PLAR e REID não aumentaram a RU da GBU e PBU. A RU do SBM para a dentina condicionada não tratada com NAPP (Controle) reduziu significativamente após um ano. O adesivo PBU apresentou maior resistência de união à dentina quando os adesivos testados foram aplicados após REID. O ácido fosfórico desmineralizou a dentina até uma profundidade de 5 mm que permitiu a penetração do adesivo nos túbulos dentinários, formando tags de resina. As estruturas interfaciais foram mantidas após um ano. O tratamento com plasma de argônio não foi benéfico no aumento da resistência de união dentinária dos adesivos à dentina condicionada em 24 horas. Entretanto, a reidratação após a aplicação do plasma evitou a redução da resistência de união do adesivo de três etapas após um ano. (PLAR (REID (RU convencionais MultiPurpose Multi Purpose adesiva, adesiva , adesiva) orgânico PrimeBond Prime orgânico. . 1 Controle, Controle 2 4 3 10 (1 microtração n=6. n6 n n=6 6 (n=6) α=0,05. α005 α α=0,05 0 05 (α=0,05) n=3 n3 (n=3 dentinaadesivo MEV (Controle dentinários Entretanto ( n= (n=6 α00 α=0,0 (α=0,05 (n= α0 α=0, (α=0,0 (n α=0 (α=0, α= (α=0 (α= (α

Abstract This study investigated the effects of nonthermal atmospheric pressure plasma (NAPP) application and dentin rehydration with water (REHY) on bond strength (BS) of adhesives. Three etch-and-rinse adhesives were tested: Scotchbond Multi-Purpose (SBM / water-based primer + adhesive resin), Gluma Bond Universal (GBU / single-bottle containing acetone as organic solvent) and Prime&Bond Universal (PBU / single-bottle containing propanol as organic solvent). Adhesives were applied: 1- to phosphoric acid-etched dentin (Control), 2- after NAPP application for 45 seconds to etched dentin or 3- after REHY with water (10 seconds) of plasma-treated etched dentin. BS was performed using human molars and microtensile test, in which specimens were tested after 24 hours or one year (n=6). BS data were analyzed by three-way mixed ANOVA and Bonferroni’s test (α=0.05). The morphology of etched dentin (n=3) and the dentin-adhesive interfaces (n=3) were evaluated using SEM. NAPP and REHY did not increase the BS of GBU and PBU. The BS of SBM to etched dentin not treated with NAPP (Control) reduced significantly after one year. The PBU adhesive showed the highest bond strength to dentin when the adhesives tested were applied after REHY. Phosphoric acid demineralized dentin to a depth of 5 mm that allowed the adhesive penetration into the dentinal tubules, forming the resin tags. Interfacial structures were maintained after one year. Argon plasma treatment was not beneficial in increasing the dentin bond strength of adhesives to etched-dentin at 24 hours. However, rehydration after plasma application prevented the bond strength reduction for three-step adhesive after one year. (NAPP (REHY (BS etchandrinse etch rinse MultiPurpose Multi Purpose waterbased based resin, , resin) singlebottle single bottle solvent PrimeBond Prime solvent. . 1 acidetched Control, Control 2 4 3 10 (1 plasmatreated n=6. n6 n n=6 6 (n=6) threeway three way Bonferronis Bonferroni s α=0.05. α005 α α=0.05 0 05 (α=0.05) n=3 n3 (n=3 dentinadhesive SEM (Control tubules tags etcheddentin However threestep step ( n= (n=6 α00 α=0.0 (α=0.05 (n= α0 α=0. (α=0.0 (n α=0 (α=0. α= (α=0 (α= (α

https://doi.org/10.1590/0103-644020246029

Microtensile bond strength of resin cements to 3-D printed and milled temporary restorative resins
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Soto-Montero, Jorge

; Romano, Beatriz de Cassia

; Noronha, Mayara dos Santos

; André, Carolina Bosso

; Giannini, Marcelo

Odovtos International Journal of Dental Sciences

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Dez 2023, Volume 25 Nº 3 Páginas 82 - 98

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

Abstract To evaluate the microtensile bond strength (µTBS) of two resin cements to 3D printed and milled CAD/CAM resins used for provisional fixed partial dentures. Blocks (5 x 5 x 5 mm) of three 3D-printed resins (Cosmos3DTemp / Yller; Resilab3D Temp / Wilcos and SmartPrint BioTemp, / MMTech) were printed (Photon, Anycubic Technology Co.). A milled material (VitaCAD-Temp, VITA) was used as control. Half the specimens were sandblasted and the rest were untreated. Two blocks were bonded with the corresponding resin cement: PanaviaV5 (Kuraray Noritake) and RelyX Ultimate (3M Oral Care). After 24 hours, the bonded blocks were sectioned into 1 x 1 mm side sticks. Half the beams were tested for µTBS and the other half was thermocycled (5000 cycles, 30s dwell-time, 5s transfer time) before µTBS testing. A four way Generalized Linear Model (material*sandblasting*cement*aging) analysis was applied. VITA exhibited the lowest µTBS, regardless of the cement, sandblasting and thermocycling. Sandblasting significantly improved the µTBS of VIT, especially after aging, but did not improve the µTBS of 3D printed resins. Sandblasting was not beneficial for 3D printed resins, although is crucial for adhesive cementation of milled temporary resins. Airborne particle abrasion affects the integrity of 3D-printed resins, without producing a benefit on the microtensile bond strength of these materials. However, sandblasting is crucial to achieve a high bond strength on milled temporary resins.

Resumen Evaluar la resistencia adhesiva en microtracción (µTBS) de dos cementos resinosos a resinas CAD/CAM impresas y fresadas indicadas para restauraciones provisionales. Bloques (5 x 5 x 5mm) de tres resinas impresas (Cosmos3DTemp / Yller; Resilab3D Temp / Wilcos and SmartPrint BioTemp, / MMTech) y una resina fresada (VitaCAD-Temp, VITA) fueron fabricados. La mitad de los especímenes fueron arenados y el resto no recibió tratamiento mecánico. Dos bloques con condiciones de tratamiento iguales fueron cementados con cemento resinoso (PanaviaV5 / Kuraray Noritake y RelyX Ultimate / 3M Oral Care). Después de 24 horas los bloques fueron seccionados en palitos de 1 mm² de área. En la mitad de los especímenes se midió la TBS inmediatamente y el resto fue termociclado (5000 ciclos, 30s remojo, 5s transferencia) antes de la prueba de TBS. Se aplica un análisis estadístico por Modelo Linear General con 4 factores (material*arenado*cemento*termociclado). La resina VITA presentó la menor µTBS, independientemente del cemento usado, el arenado y el termociclado. Sin embargo, el arenado aumentó la µTBS de VIT, especialmente después del termociclado. Por otro lado, el arenado no resultó en un aumento significativo de la µTBS de las resinas impresas. El arenado no fue beneficiosos para las resinas impresas, aunque es un paso crucial para la cementación adhesive de las resinas fresadas. El arenado afecta la integridad de las capas de las resinas impresas, sin generar un beneficio en la TBS.

https://doi.org/10.15517/ijds.2023.55808

Toothbrushing effects on the surface roughness and cement volume loss of bonded enamel-ceramic interface enamelceramic enamel ceramic
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Marins, Luísa de Almeida Vieira

; Araújo-Neto, Vitaliano Gomes

; Sahadi, Beatriz Ometto

; André, Carolina Bosso

; Giannini, Marcelo

Brazilian Dental Journal

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Out 2023, Volume 34 Nº 5 Páginas 63 - 71

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este estudo avaliou o efeito da escovação nas interfaces de união esmalte-material cimentante-cerâmica, utilizando diferentes materiais cimentantes. Materiais e Métodos: Trinta esmaltes e trinta blocos cerâmicos foram unidos com materiais de cimentação para produzir as amostras que foram unidas com três tipos de materiais de cimentação: 1- cimento resinoso RelyX Ultimate (REXU), 2- cimento resinoso autoadesivo RelyX Unicem 2 (REU2) e 3-compósito restaurador aquecido Z100 (60°C). As interfaces coladas das amostras foram escovadas e as superfícies dos 3 materiais cimentantes foram avaliadas quanto à rugosidade (RG, em µm), perfil de rugosidade (RP, em µm) e perda de volume (VL, em µm3) (baseline e após 20.000 e 60.000 ciclos de escovação). Os dados foram avaliados por Análise Linear Generalizada (dois fatores: “material” e “ciclo de escovação”) e teste de Bonferroni (α=0,05). Resultados: REXU e Z100 apresentaram menor RG do que REU2, exceto após 60.000 ciclos de escovação, quando Z100 diferiu apenas de REU2. O aumento dos ciclos de escovação aumentou o RG e RP para todos os materiais. O REU2 também apresentou PR maior que o REXU e Z100, quando analisado em relação ao esmalte. O VL de Z100 foi o menor com 20.000 ciclos de escovação em relação ao esmalte e cerâmica. Para 60.000 ciclos, o REXU apresentou o menor VL em relação à cerâmica e o REU2 o maior VL em relação ao esmalte e à cerâmica. Conclusão: De maneira geral, REXU e Z100 apresentaram os melhores resultados nas avaliações realizadas e o REU2 apresentou os maiores RG, RP e VL.. esmaltematerial material cimentantecerâmica, cimentantecerâmica cimentante cerâmica, cimentante-cerâmica Métodos 1 REXU, , (REXU) REU (REU2 3compósito compósito Z Z10 60°C. 60C C 60°C . 60 (60°C) (RG µm, µm RP, (RP VL, (VL µm3 baseline 20000 20 000 20.00 60000 60.00 escovação. escovação) dois fatores “material ciclo escovação” α=0,05. α005 α α=0,05 0 05 (α=0,05) Resultados Conclusão geral VL. (REXU (REU Z1 6 (60°C 2000 00 20.0 6000 60.0 α00 α=0,0 (α=0,05 200 20. 600 60. α0 α=0, (α=0,0 α=0 (α=0, α= (α=0 (α= (α

Abstract This study evaluated the effect of toothbrushing on enamel-cementing material-ceramic bonded interfaces, using different cementing materials. Materials and Methods: Thirty enamel and thirty ceramic blocks were bonded with cementing materials to produce the samples that were bonded with three types of cementing materials: 1- RelyX Ultimate resin cement (REXU), 2- RelyX Unicem 2 self-adhesive resin cement (REU2) and 3- heated Z100 restorative composite (60°C). Bonded interfaces of the samples were toothbrushed and the surfaces of the 3 cementing materials were evaluated for roughness (RG, in µm), roughness profile (RP, in µm), and volume loss (VL, in µm3) (baseline and after 20,000 and 60,000 toothbrushing cycles). Data were evaluated by Generalized Linear Analysis (two factors: “material” and “toothbrushing cycle”) and Bonferroni test (α=0.05). Results: REXU and Z100 exhibited lower RG than that presented by REU2, except after 60,000 toothbrushing cycles when only Z100 differed from REU2. The increase in toothbrushing cycles increased the RG and RP for all materials. REU2 also showed higher RP than those showed by REXU and Z100 when it was analyzed regarding the enamel. The VL of Z100 was the lowest with 20,000 toothbrushing cycles, regarding the enamel and ceramic. For 60,000 cycles, REXU showed the lowest VL regarding the ceramic, and REU2 had the highest VL regarding the enamel and ceramic. Conclusion: In general, REXU and Z100 showed the best results regarding the evaluations performed and the REU2 exhibited the highest RG, RP, and VL. enamelcementing materialceramic material Methods 1 REXU, , (REXU) selfadhesive self adhesive REU (REU2 Z Z10 60°C. 60C C 60°C . 60 (60°C) (RG µm, µm µm) (RP VL, (VL µm3 baseline 20000 20 000 20,00 60000 60,00 cycles. cycles) two factors “material cycle cycle” α=0.05. α005 α α=0.05 0 05 (α=0.05) Results Conclusion general (REXU (REU Z1 6 (60°C 2000 00 20,0 6000 60,0 α00 α=0.0 (α=0.05 200 20, 600 60, α0 α=0. (α=0.0 α=0 (α=0. α= (α=0 (α= (α

https://doi.org/10.1590/0103-6440202305459

Effect of whitening toothpastes and activated charcoal powder on enamel wear and surface roughness
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CARNEIRO, Bruna Tavares

; KURY, Matheus

; LOPES, Jovana Cacique

; GONÇALVES, Rafael Silva

; SUZUKI, Thais Yumi Umeda

; PICOLO, Mayara Zaghi dal

; GIANNINI, Marcelo

; ANDRÉ, Carolina Bosso

Brazilian Oral Research

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2023, Volume 37 elocation e092

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to evaluate surface roughness (Sa), roughness profile (Rv), and enamel wear after brushing with different whitening toothpastes and charcoal powders. Sixty (n = 10) bovine enamel blocks (6 × 6 × 3 mm) were randomly distributed into six groups according to toothpaste type: regular toothpaste (CONT), toothpaste containing 2% hydrogen peroxide (HP), toothpaste containing titanium dioxide (TiO2), toothpaste containing charcoal (COAL), toothpaste containing charcoal and TiO2 (COAL+TiO2), and activated charcoal powder (COAL_PWD). Each block was subjected to 30,000 reciprocal cycles at a 1:3 proportion slurry. After brushing, the blocks were analyzed using an optical profilometer to determine Sa, Rv, and enamel wear. In addition, representative 3D images of each group and wear profiles were obtained. Sa was analyzed using generalized linear models followed by Bonferroni correction, whereas Rv was analyzed using one-way analysis of variance. After brushing, COAL and COAL+TiO2 showed higher Sa values than COAL_PWD. However, no significant difference was observed in Sa between whitening toothpaste and COAL_PWD, and CONT (p > 0.05). In addition, no differences were observed among the groups in Rv (p > 0.05). Conversely, enamel wear was higher for TiO2, COAL, COAL+TiO2, and COAL_PWD than for CONT. CONT showed the least enamel wear, whereas HP showed intermediate values. Representative 3D images and line profiles showed lower step-height and lower mean surface losses for the CONT and HP groups than for the other groups. Whitening toothpastes and COAL_PWD did not increase Sa or Rv compared with CONT, while CONT demonstrated lower enamel wear.

https://doi.org/10.1590/1807-3107bor-2023.vol37.0092

Effects of argon plasma and aging on the mechanical properties and phase transformation of 3Y-TZP zirconia
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Negreiros, William Matthew

; Cotta, Monica Alonso

; Rueggeberg, Frederick Allen

; Bonvent, Jean Jacques

; Nascimento, Fabio Dupart

; Giannini, Marcelo

Brazilian Dental Journal

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Out 2022, Volume 33 Nº 5 Páginas 100 - 107

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Avaliar a resistência à flexão (FS) e o módulo de flexão (FM) de uma cerâmica comercial 3Y-TZP após envelhecimento artificial, e com ou sem dois tempos de aplicação de plasma não térmico (NTP). Além disso, a transformação de fase cristalina e a nano-topografia de superfície após a aplicação de NTP, durante diferentes períodos de envelhecimento, foram avaliadas. Noventa barras 3Y-TZP (45x4x3 mm) foram feitas para testes de FS e FM, e distribuídas em nove grupos (n=10): sem NTP/sem envelhecimento (Controle); sem NTP/4h de envelhecimento; sem NTP/30h de envelhecimento; 10sNTP/sem envelhecimento; 10sNTP/4h; 10sNTP/30h; 60sNTP/sem envelhecimento; 60sNTP/4h e 60sNTP/30h. O envelhecimento artificial acelerado foi simulado em autoclave (134º C a 2 bar) por até 30 horas. FS e FM foram avaliados em máquina de ensaio universal e os dados analisados pela ANOVA e teste de Tukey (α = 0,05). A mudança de volume da fase monoclínica de zircônia (MPV) foi avaliada usando difração de raios-X e nano-topografia de superfície foi avaliada utilizando microscopia de força atômica (baseline até 30h). A aplicação do NTP não influenciou a FS e FM da zircônia. Comparado ao Controle (“sem NTP/sem envelhecimento”), a FS das amostras de zircônia tratadas por 30 horas em autoclave (“sem NTP/30h de envelhecimento”) aumentou. O envelhecimento artificial por 30 horas aumentou significativamente a FM da zircônia, independente do tempo de aplicação do NTP. O MPV tendeu a aumentar em função do aumento do tempo de envelhecimento para todos os grupos, que pode ter resultado nas irregularidades superficiais observadas com 30 horas de envelhecimento. O NTP não afetou as propriedades da zircônia testadas, mas o envelhecimento por 30 horas pode alterar a FS, FM e MPV da zircônia.

Abstract To evaluate the flexural strength (FS) and flexural modulus (FM) of a commercial 3Y-TZ0P ceramic after artificial aging and either without or with two application times of non-thermal plasma treatments (NTP). In addition, changes in crystalline phase transformation and surface nano-topography after NTP application, during different aging periods, were evaluated. Ninety 3Y-TZP bars (45x4x3 mm) were made for FS and FM testing, and assigned to nine groups (n=10): no NTP/no aging (Control); no NTP/4h aging; no NTP/30h aging; 10s NTP/no aging; 10s NTP/4h aging; 10s NTP/30h aging; 60s NTP/no aging; 60s NTP/4h aging and 60s NTP/30h aging. Artificial accelerated aging was simulated using an autoclave (134º C at 2 bar) for up to 30h. FS and FM were assessed using a universal testing machine and data analyzed using a ANOVA and Tukey test (α=0.05). The volume change in zirconia monoclinic phase (MPV) was evaluated using X-ray diffraction and surface nano-topography was assessed using atomic force microscopy (baseline until 30h-aging). NTP application did not influence the FS and FM of zirconia. Compared to the Control (no NTP/no aging), the FS of zirconia samples treated for 30 hours in autoclave (“no NTP/30h aging” group) increased. Artificial aging for 30 hours significantly increased the FM of zirconia, regardless of NTP application. MPV tended to increase following the increase in aging time, which might result in the surface irregularities observed at 30h-aging. NTP did not alter the zirconia properties tested, but 30h-aging can change the zirconia FS, FM and MPV.

https://doi.org/10.1590/0103-6440202204849

Association of solvents improves selected properties of experimental dental adhesives
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Silvestre, Francisbênia Alves

; Araújo Neto, Vitaliano Gomes de

; Giannini, Marcelo

; Rifane, Tainah Oliveira

; Cordeiro, Karen Evellin Moura

; Medeiros, Samara Tabata Cavalcante Braga

; Lomonaco, Diego

; Moreira, Madiana Magalhães

; Alves, Adyson Herbert Correia

; Feitosa, Victor Pinheiro

Brazilian Oral Research

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2022, Volume 36 elocation e093

Resumo: En | Texto: En | PDF: En

Abstract: The aim of the study was to evaluate how the association of solvents (tetrahydrofuran [THF], dimethyl sulfoxide [DMSO], ethanol [ET] or acetone [ACT]) with experimental dental adhesives affects selected properties of experimental dental adhesives and dentin bond durability. Six adhesive combinations were prepared containing: 30 % ET, 30 % ACT, 30 % THF, 28 % ET + 2 % DMSO (ET+DMSO), 15 % ethanol + 15 % THF (ET+THF), or 28 % THF + 2 % DMSO (THF+DMSO). Thirty-six molars (n = 6) were cut to expose the coronary dentin, and were randomly divided according to the adhesives. They were restored, and then cut into resindentin sticks (1 mm²), and stored in distilled water for 24 h or 6 months, until conducting the microtensile bond strength and nanoleakage tests. Other experiments performed with adhesives included viscosity assessment using a rheometer, and degree of conversion using Fourier-transform infrared spectroscopy (FTIR). The data were analyzed statistically using two-way ANOVA and Tukey’s test (p < 0.05). The adhesive formulated exclusively with THF showed the highest viscosity, followed by ET+THF, which obtained the highest degree of conversion compared to ET, and THF alone. ET+DMSO obtained the highest 24-h and aged bond strengths (p < 0.05). ET+THF increased the nanoleakage slightly after 6 months, but attained the only gap-free adhesive interface among all the groups. The combination of alternative solvents, particularly THF, with conventional ones (ET) has improved chemical properties, and the dentin bonding of experimental simplified adhesives.

https://doi.org/10.1590/1807-3107bor-2022.vol36.0093

Microhardness homogeneity of RBCs light-cured with a multiple-peak LED and surface characterization after wear
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Sahadi, Beatriz Ometto

; Nima, Gabriel

; Andre, Carolina Bosso

; Sebold, Maicon

; Palma-Dibb, Regina Guenka

; Faraoni, Juliana Jendiroba

; Giannini, Marcelo

Brazilian Dental Journal

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Jun 2021, Volume 32 Nº 3 Páginas 92 - 104

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Este estudo in vitro avaliou a homogeneidade do feixe de um fotopolimerizador de múltiplos picos na microdureza superficial e o efeito da escovação na microdureza, rugosidade superficial, perfil de rugosidade, perda de volume e retenção do brilho de compósitos a base de resina (RBCs) incrementais ou bulk-fill. Um fotopolimerizador LED (VALO) com quatro LEDs na ponteira (405, 445, 465A e 465B nm de pico de emissão) foi usado de acordo com o tempo recomendado por cada fabricante para obtenção de discos (n=10) de seis RBCs: Estelite Sigma Quick, Charisma Classic, Tetric EvoCeram Bulk Fill, Filtek Z250, Filtek Supreme Ultra e Filtek Bulk Fill. Os valores de microdureza foram obtidos seguindo o posicionamento de cada LED na superfície superior das amostras e foram analisados antes e após a escovação quanto a microdureza, rugosidade superficial, perfil de rugosidade, perda de volume e retenção do brilho. A microdureza foi considerada homogênea no topo da superfície, independentemente do tipo de RBCs ou comprimento de onda testados (p>0.05). No geral, a escovação não reduziu a microdureza das RBCs, mas influenciou o brilho para a maioria das RBCs (p<0.001). Charisma Classic apresentou os maiores valores de rugosidade superficial e perfil de rugosidade após a escovação (p<0.05). A perda de volume não diferiu entre as RBCs (p>0.05). Em conclusão, os diferentes comprimentos de onda do LED não alteraram a microdureza do topo da superfície, independentemente das RBCs testadas; e as resinas bulk-fill apresentaram alterações superficiais similares (microdureza, rugosidade superficial, perfil de rugosidade, perda de volume e manutenção do brilho) quando comparadas às resinas convencionais após a escovação.

Abstract This in vitro study evaluated the effect of the beam homogeneity of a multiple-peak light-curing unit on the surface microhardness and the effect of toothbrushing wear on the microhardness, surface roughness, roughness profile, volume loss, and gloss retention of incremental and bulk-fill resin-based composites (RBCs). A LED light-curing unit (VALO) with four LEDs at the tip end (405, 445, 465A, and 465B nm emission peak) was used according to each manufacturer-recommended time to obtain disks (n=10) of six RBCs: Estelite Sigma Quick, Charisma Classic, Tetric EvoCeram Bulk Fill, Filtek Z250, Filtek Supreme Ultra, and Filtek Bulk Fill. Microhardness values were obtained according to each LED positioning of the light-curing unit on the top surface of the RBCs and were analyzed before and after toothbrushing regarding microhardness, surface roughness, roughness profile, volume loss, and gloss retention. Microhardness was considered homogeneous on the top surface regardless of the type of RBC or wavelength tested (p>0.05). Overall, toothbrushing did not reduce the microhardness of the RBCs but influenced the gloss values for most RBCs (p<0.001). Charisma Classic presented the greatest surface roughness and roughness profile after toothbrushing (p<0.05). Volume loss did not differ among RBCs (p>0.05). In conclusion, different wavelengths of the LED did not affect the top surface microhardness, regardless of the RBCs tested; and bulk-fill composites presented similar surface changes (microhardness, surface roughness, roughness profile, volume loss, and gloss retention) when compared to conventional composites after toothbrushing.

https://doi.org/10.1590/0103-6440202104044 23 downloads

10.

Práticas de ressuscitação volêmica em unidades de terapia intensiva brasileiras: uma análise secundária do estudo Fluid-TRIPS
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Freitas, Flavio Geraldo Rezende de

; Hammond, Naomi

; Li, Yang

; Azevedo, Luciano Cesar Pontes de

; Cavalcanti, Alexandre Biasi

; Taniguchi, Leandro

; Gobatto, André

; Japiassú, André Miguel

; Bafi, Antonio Tonete

; Mazza, Bruno Franco

; Noritomi, Danilo Teixeira Dal-Pizzol, Felipe Bozza, Fernando Salluh, Jorge Ibrahin Figueira Westphal, Glauco Adrieno Soares, Márcio Assunção, Murillo Santucci César de Lisboa, Thiago Lobo, Suzana Margarete Ajeje Barbosa, Achilles Rohlfs Ventura, Adriana Fonseca Souza, Ailson Faria de Silva, Alexandre Francisco Toledo, Alexandre Reis, Aline Cembranel, Allan Rea Neto, Alvaro Gut, Ana Lúcia Justo, Ana Patricia Pierre Santos, Ana Paula Albuquerque, André Campos D. de Scazufka, André Rodrigues, Antonio Babo Fernandino, Bruno Bonaccorsi Silva, Bruno Goncalves Vidal, Bruno Sarno Pinheiro, Bruno Valle Pinto, Bruno Vilela Costa Feijo, Carlos Augusto Ramos Abreu Filho, Carlos de Bosso, Carlos Eduardo da Costa Nunes Moreira, Carlos Eduardo Nassif Ramos, Carlos Henrique Ferreira Tavares, Carmen Arantes, Cidamaiá Grion, Cintia Mendes, Ciro Leite Kmohan, Claudio Piras, Claudio Castro, Cristine Pilati Pileggi Lins, Cyntia Beraldo, Daniel Fontes, Daniel Boni, Daniela Castiglioni, Débora Paisani, Denise de Moraes Pedroso, Durval Ferreira Fonseca Mattos, Ederson Roberto Brito Sobrinho, Edgar de Troncoso, Edgar M. V. Rodrigues Filho, Edison Moraes Nogueira, Eduardo Enrico Ferrari Ferreira, Eduardo Leme Pacheco, Eduardo Souza Jodar, Euzebio Ferreira, Evandro L. A. Araujo, Fabiana Fernandes de Trevisol, Fabiana Schuelter Amorim, Fábio Ferreira Giannini, Fabio Poianas Santos, Fabrício Primitivo Matos Buarque, Fátima Lima, Felipe Gallego Costa, Fernando Antonio Alvares da Sad, Fernando Cesar dos Anjos Aranha, Fernando G. Ganem, Fernando Callil, Flavio Costa Filho, Francisco Flávio Dall´Arto, Frederico Toledo Campo Moreno, Geovani Friedman, Gilberto Moralez, Giulliana Martines Silva, Guilherme Abdalla da Costa, Guilherme Cavalcanti, Guilherme Silva Cavalcanti, Guilherme Silva Betônico, Gustavo Navarro Betônico, Gustavo Navarro Reis, Hélder Araujo, Helia Beatriz N. Hortiz Júnior, Helio Anjos Guimaraes, Helio Penna Urbano, Hugo Maia, Israel Santiago Filho, Ivan Lopes Farhat Júnior, Jamil Alvarez, Janu Rangel Passos, Joel Tavares Paranhos, Jorge Eduardo da Rocha Marques, José Aurelio Moreira Filho, José Gonçalves Andrade, Jose Neto Sobrinho, José Onofre de C Bezerra, Jose Terceiro de Paiva Alves, Juliana Apolônio Ferreira, Juliana Gomes, Jussara Sato, Karina Midori Gerent, Karine Teixeira, Kathia Margarida Costa Conde, Katia Aparecida Pessoa Martins, Laércia Ferreira Figueirêdo, Lanese Rezegue, Leila Tcherniacovsk, Leonardo Ferraz, Leone Oliveira Cavalcante, Liane Rabelo, Ligia Miilher, Lilian Garcia, Lisiane Tannous, Luana Hajjar, Ludhmila Abrahão Paciência, Luís Eduardo Miranda Cruz Neto, Luiz Monteiro da Bley, Macia Valeria Sousa, Marcelo Ferreira Puga, Marcelo Lourencini Romano, Marcelo Luz Pereira Nobrega, Marciano Arbex, Marcio Rodrigues, Márcio Leite Guerreiro, Márcio Osório Rocha, Marcone Alves, Maria Angela Pangoni Alves, Maria Angela Pangoni Rosa, Maria Doroti Dias, Mariza D’Agostino Martins, Miquéias Oliveira, Mirella de Moretti, Miriane Melo Silveira Matsui, Mirna Messender, Octavio Santarém, Orlando Luís de Andrade Silveira, Patricio Júnior Henrique da Vassallo, Paula Frizera Antoniazzi, Paulo Gottardo, Paulo César Correia, Paulo Ferreira, Paulo Torres, Paulo Silva, Pedro Gabrile M. de Barros e Foernges, Rafael Gomes, Rafael Moraes, Rafael Nonato filho, Raimundo Borba, Renato Luis Gomes, Renato V Cordioli, Ricardo Lima, Ricardo López, Ricardo Pérez Gargioni, Ricardo Rath de Oliveira Rosenblat, Richard Souza, Roberta Machado de Almeida, Roberto Narciso, Roberto Camargo Marco, Roberto waltrick, Roberto Biondi, Rodrigo Figueiredo, Rodrigo Dutra, Rodrigo Santana Batista, Roseane Felipe, Rouge Franco, Rubens Sergio da Silva Houly, Sandra Faria, Sara Socorro Pinto, Sergio Felix Luzzi, Sergio Sant’ana, Sergio Fernandes, Sergio Sonego Yamada, Sérgio Zajac, Sérgio Vaz, Sidiner Mesquita Bezerra, Silvia Aparecida Bezerra Farhat, Tatiana Bueno Tardivo Santos, Thiago Martins Smith, Tiago Silva, Ulysses V. A. Damasceno, Valnei Bento Nobre, Vandack Dantas, Vicente Cés de Souza Irineu, Vivian Menezes Bogado, Viviane Nedel, Wagner Campos Filho, Walther Dantas, Weidson Viana, William Oliveira Filho, Wilson de Delgadinho, Wilson Martins Finfer, Simon Machado, Flavia Ribeiro

Revista Brasileira de Terapia Intensiva

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Abr 2021, Volume 33 Nº 2 Páginas 206 - 218

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Objetivo: Descrever as práticas de ressuscitação volêmica em unidades de terapia intensiva brasileiras e compará-las com as de outros países participantes do estudo Fluid-TRIPS. Métodos: Este foi um estudo observacional transversal, prospectivo e internacional, de uma amostra de conveniência de unidades de terapia intensiva de 27 países (inclusive o Brasil), com utilização da base de dados Fluid-TRIPS compilada em 2014. Descrevemos os padrões de ressuscitação volêmica utilizados no Brasil em comparação com os de outros países e identificamos os fatores associados com a escolha dos fluidos. Resultados: No dia do estudo, foram incluídos 3.214 pacientes do Brasil e 3.493 pacientes de outros países, dos quais, respectivamente, 16,1% e 26,8% (p < 0,001) receberam fluidos. A principal indicação para ressuscitação volêmica foi comprometimento da perfusão e/ou baixo débito cardíaco (Brasil 71,7% versus outros países 56,4%; p < 0,001). No Brasil, a percentagem de pacientes que receberam soluções cristaloides foi mais elevada (97,7% versus 76,8%; p < 0,001), e solução de cloreto de sódio a 0,9% foi o cristaloide mais comumente utilizado (62,5% versus 27,1%; p < 0,001). A análise multivariada sugeriu que os níveis de albumina se associaram com o uso tanto de cristaloides quanto de coloides, enquanto o tipo de prescritor dos fluidos se associou apenas com o uso de cristaloides. Conclusão: Nossos resultados sugerem que cristaloides são usados mais frequentemente do que coloides para ressuscitação no Brasil, e essa discrepância, em termos de frequências, é mais elevada do que em outros países. A solução de cloreto de sódio 0,9% foi o cristaloide mais frequentemente prescrito. Os níveis de albumina sérica e o tipo de prescritor de fluidos foram os fatores associados com a escolha de cristaloides ou coloides para a prescrição de fluidos.

Abstract Objective: To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS. Methods: This was a prospective, international, cross-sectional, observational study in a convenience sample of intensive care units in 27 countries (including Brazil) using the Fluid-TRIPS database compiled in 2014. We described the patterns of fluid resuscitation use in Brazil compared with those in other countries and identified the factors associated with fluid choice. Results: On the study day, 3,214 patients in Brazil and 3,493 patients in other countries were included, of whom 16.1% and 26.8% (p < 0.001) received fluids, respectively. The main indication for fluid resuscitation was impaired perfusion and/or low cardiac output (Brazil: 71.7% versus other countries: 56.4%, p < 0.001). In Brazil, the percentage of patients receiving crystalloid solutions was higher (97.7% versus 76.8%, p < 0.001), and 0.9% sodium chloride was the most commonly used crystalloid (62.5% versus 27.1%, p < 0.001). The multivariable analysis suggested that the albumin levels were associated with the use of both crystalloids and colloids, whereas the type of fluid prescriber was associated with crystalloid use only. Conclusion: Our results suggest that crystalloids are more frequently used than colloids for fluid resuscitation in Brazil, and this discrepancy in frequencies is higher than that in other countries. Sodium chloride (0.9%) was the crystalloid most commonly prescribed. Serum albumin levels and the type of fluid prescriber were the factors associated with the choice of crystalloids or colloids for fluid resuscitation.

https://doi.org/10.5935/0103-507x.20210028 273 downloads

11.

Synthesis, characterization, and incorporation of upconverting nanoparticles into a dental adhesive
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Pacheco, Rafael Rocha

; Garcia-Flores, Ali Francisco

; Soto-Montero, Jorge Rodrigo

; Lesseux, Guilherme Gorgen

; Lancelotti, Ailla Carla Rocha Acosta

; Martinez, Eduardo David

; Rettori, Carlos

; Urbano, Ricardo Rodrigues

; Rueggeberg, Frederick Allen

; Giannini, Marcelo

Brazilian Oral Research

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2021, Volume 35 elocation e120

Resumo: En | Texto: En | PDF: En

Abstract: The purpose of this study was to describe the synthesis, characterization, and functionalization of b-NaYF4:30%Yb/0.5%Tm upconverting nanocrystals for use as nanofillers in a dental adhesive and microscopically evaluate the interface between the particles and a commercial adhesive. The upconverting nanoparticles were synthesized and purified by thermal decomposition, and their chemical composition determined by energy dispersive X-Ray spectroscopy. The crystalline structure was characterized using X-Ray diffraction and morphology and size were observed with scanning and transmission electron microscopy. Upconverting emission was evaluated by spectrophotometry irradiating the particles with a 975 nm diode laser. Particles were functionalized with polyacrylic acid and the success was confirmed by measurement of Zeta Potential and transmission electron microscopy. The results of X-ray diffraction found a pure hexagonal phase crystalline pattern. Scanning electron microscopy showed uniform dispersion of hexagonal-shaped particles of approximately 150 nm. Upconversion emission was observed in 344 nm, 361 nm, 450 nm, 474nm, 646 nm, 803 nm. Functionalization success was confirmed by formation of a stable aqueous colloid with a Zeta potential of −29.5mV and the absence of voids in the particle-adhesive interface on the transmission electron microscopy images. The reported synthesis and functionalization process produced upconverting nanoparticles emitting photons within the blue spectral region (450 nm and 474 nm).

https://doi.org/10.1590/1807-3107bor-2021.vol35.0120 1 downloads

12.

Combination of at-home and in-office bleaching techniques: case series
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FERRETTI, Marcela Alvarez

; KURY, Matheus

; MENDONÇA, Beatriz Curvello de

; GIANNINI, Marcelo

; CAVALLI, Vanessa

; AGUIAR, Flávio Henrique Baggio

RGO - Revista Gaúcha de Odontologia

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2021, Volume 69 elocation e20210036

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO O clareamento dental é uma das técnicas estéticas mais conservadoras no âmbito odontológico. Técnicas de clareamento caseira ou de consultório, ou a combinação de ambas, podem ser realizadas para alcançar o prognóstico desejado. Esta combinação das técnicas pode ser realizada por meio de diferentes abordagens, como apresentado neste relato de casos. Um paciente do gênero masculino, 24 anos de idade, cujos incisivo central superior e caninos apresentaram cor A2 e A3, respectivamente, foi inicialmente submetido à técnica de clareamento de consultório de duração por sessão de 40 mim com gel de peróxido de hidrogênio (PH) 40%, em duas sessões. Posteriormente, a técnica de clareamento caseira foi realizada durante duas semanas com gel de peróxido de carbamida (PC) a uma concentração de 10%.A cor final dos incisivos centrais superiores foi alterada para 1M1, enquanto a dos caninos para B1. Por outro lado, uma paciente do gênero feminino, 30 anos de idade, foi inicialmente submetida ao clareamento caseiro (durante a noite, por 4 semanas- PC 10%), e subsequentemente, com aplicação pontual de agente clareador (PH 35%) em consultório, em sessão de 45 min. A cor do incisivo central superior da paciente, mudou de A1 para 0,5M1 e do canino superior de A3 para B1. As escalas de cor VITA Classic (A1-D4), e VITA Bleachedguided 3D-MASTER foram utilizadas nesta série de casos para determinar a coloração dos dentes durante os tratamentos. Em ambos os tratamentos, os pacientes não reportaram sensibilidade dental significante, e suas expectativas finais foram atendidas.

ABSTRACT Tooth bleaching is one of the most conservative aesthetic techniques. At-home and in-office bleaching may be performed, as well as the combination of both techniques. As this combination may be done in different manners, distinct orders of combinations were proposed in this report. A 24 years-old man, whose upper central incisor and canine shades were A2 and A3 respectively, was initially treated by chair-side with 40-min application of 40% hydrogen peroxide (HP) for two sessions. Afterwards, an two-week overnight at-home bleaching was performed with 10% carbamide peroxide (CP). The shade of upper central incisors changed to 1M1 and canine was B1. Conversely, a 30 years-old woman was firstly conducted with at-home bleaching (overnight 4-weeks 10% CP) and, subsequently, with a single appointment of in-office bleaching for 45 minutes (35% HP). The shade of her upper central incisor changed from A1 to 0.5M1 and the upper canine from A3 to B1. The VITA classical (A1-D4) shade guide and VITA Bleached guide 3D-MASTER were used to determine the tooth color during the treatments. In both bleaching treatments, patients reported no significant tooth sensitivity and the final outcomes met their expectation.

https://doi.org/10.1590/1981-863720200003620190149 50 downloads

13.

COVID-19: The question of genetic diversity and therapeutic intervention approaches
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Figueiredo, David Livingstone Alves

; Ximenez, João Paulo Bianchi

; Seiva, Fábio Rodrigues Ferreira

; Panis, Carolina

; Bezerra, Rafael dos Santos

; Ferrasa, Adriano

; Cecchini, Alessandra Lourenço

; Medeiros, Alexandra Ivo de

; Almeida, Ana Marisa Fusco

; Ramão, Anelisa

; Boldt, Angelica Beate Winter

; Moya, Carla Fredrichsen Chin, Chung Man Paula, Daniel de Rech, Daniel Gradia, Daniela Fiori Malheiros, Danielle Venturini, Danielle Tavares, Eliandro Reis Carraro, Emerson Ribeiro, Enilze Maria de Souza Fonseca Pereira, Evani Marques Tuon, Felipe Francisco Follador, Franciele Aní Caovilla Fernandes, Glaura Scantamburlo Alves Volpato, Hélito Cólus, Ilce Mara de Syllos Oliveira, Jaqueline Carvalho de Rodrigues, Jean Henrique da Silva Santos, Jean Leandro dos Visentainer, Jeane Eliete Laguila Brandi, Juliana Cristina Serpeloni, Juliana Mara Bonini, Juliana Sartori Oliveira, Karen Brajão de Fiorentin, Karine Lucio, Léia Carolina Faccin-Galhardi, Ligia Carla Ferreto, Lirane Elize Defante Lioni, Lucy Megumi Yamauchi Consolaro, Marcia Edilaine Lopes Vicari, Marcelo Ricardo Arbex, Marcos Abdo Pileggi, Marcos Watanabe, Maria Angelica Ehara Costa, Maria Antônia Ramos Giannini, Maria José S. Mendes Amarante, Marla Karine Khalil, Najeh Maissar Lima Neto, Quirino Alves de Herai, Roberto H. Guembarovski, Roberta Losi Shinsato, Rogério N. Mainardes, Rubiana Mara Giuliatti, Silvana Yamada-Ogatta, Sueli Fumie Gerber, Viviane Knuppel de Quadros Pavanelli, Wander Rogério Silva, Weber Claudio da Petzl-Erler, Maria Luiza Valente, Valeria Soares, Christiane Pienna Cavalli, Luciane Regina Silva Jr, Wilson Araujo

Genetics and Molecular Biology

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2021, Volume 44 Nº 1 elocation e20200452

Resumo: En | Texto: En | PDF: En

Abstract Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), is the largest pandemic in modern history with very high infection rates and considerable mortality. The disease, which emerged in China’s Wuhan province, had its first reported case on December 29, 2019, and spread rapidly worldwide. On March 11, 2020, the World Health Organization (WHO) declared the COVID-19 outbreak a pandemic and global health emergency. Since the outbreak, efforts to develop COVID-19 vaccines, engineer new drugs, and evaluate existing ones for drug repurposing have been intensively undertaken to find ways to control this pandemic. COVID-19 therapeutic strategies aim to impair molecular pathways involved in the virus entrance and replication or interfere in the patients’ overreaction and immunopathology. Moreover, nanotechnology could be an approach to boost the activity of new drugs. Several COVID-19 vaccine candidates have received emergency-use or full authorization in one or more countries, and others are being developed and tested. This review assesses the different strategies currently proposed to control COVID-19 and the issues or limitations imposed on some approaches by the human and viral genetic variability.

https://doi.org/10.1590/1678-4685-gmb-2020-0452

14.

Effect of violet LED light on in-office bleaching protocols: a randomized controlled clinical trial
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KURY, Matheus

; WADA, Erica Eiko

; SILVA, Daylana Pacheco da

; TABCHOURY, Cínthia Pereira Machado

; GIANNINI, Marcelo CAVALLI, Vanessa

Journal of Applied Oral Science

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2020, Volume 28 elocation e20190720

Resumo: En | Texto: En | PDF: En

Abstract Objective This study evaluated the clinical effect of violet LED light on in-office bleaching used alone or combined with 37% carbamide peroxide (CP) or 35% hydrogen peroxide (HP). Methodology A total of 100 patients were divided into five groups (n=20): LED, LED/CP, CP, LED/HP and HP. Colorimetric evaluation was performed using a spectrophotometer (ΔE, ΔL, Δa, Δb) and a visual shade guide (ΔSGU). Calcium (Ca)/phosphorous (P) ratio was quantified in the enamel microbiopsies. Measurements were performed at baseline (T 0 ), after bleaching (T B ) and in the 14-day follow-up (T 14 ). At each bleaching session, a visual scale determined the absolute risk (AR) and intensity of tooth sensitivity (TS). Data were evaluated by one-way (ΔE, Δa, ΔL, Δb), two-way repeated measures ANOVA (Ca/P ratio), and Tukey post-hoc tests. ΔSGU and TS were evaluated by Kruskal-Wallis and Mann-Whitney, and AR by Chi-Squared tests (a=5%). Results LED produced the lowest ΔE (p<0.05), but LED/HP promoted greater ΔE, ΔSGU and Δb (T 14 ) than HP (p<0.05). No differences were observed in ΔE and ΔSGU for LED/CP and HP groups (p>0.05). ΔL and Δa were not influenced by LED activation. After bleaching, LED/CP exhibited greater Δb than CP (p>0.05), but no differences were found between these groups at T 14 (p>0.05). LED treatment promoted the lowest risk of TS (16%), while HP promoted the highest (94.4%) (p<0.05). No statistical differences of risk of TS were found for CP (44%), LED/CP (61%) and LED/HP (88%) groups (p>0.05). No differences were found in enamel Ca/P ratio among treatments, regardless of evaluation times. Conclusions Violet LED alone produced the lowest bleaching effect, but enhanced HP bleaching results. Patients treated with LED/CP reached the same efficacy of HP, with reduced risk and intensity of tooth sensitivity and none of the bleaching protocols adversely affected enamel mineral content.

https://doi.org/10.1590/1678-7757-2019-0720 2599 downloads

15.

Accuracy of Irradiance and Power of Light-Curing Units Measured With Handheld or Laboratory Grade Radiometers
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Giannini, Marcelo

; André, Carolina Bosso

; Gobbo, Vanessa Cavalli

; Rueggeberg, Frederick Allen

Brazilian Dental Journal

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Jul 2019, Volume 30 Nº 4 Páginas 397 - 403

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Esse estudo mensurou e comparou a irradiância e a energia de quatro fotopolimerizadores comerciais (Elipar S10, Elipar DeepCure-S, Corded VALO e Bluephase Style) utilizando diferentes tipos de radiômetros. Os dispositivos utilizados para analisar os fotopolimerizadores foram classificados em portáteis analógicos (Henry Schein, Spring, Demetron 100A, Demetron 100B e Demetron 200), portáteis digitais (Bluephase 1, Bluephase II, Coltolux, CureRite e Hilux), ou instrumentos laboratoriais (Thermopile e Integrating Sphere). Os instrumentos laboratoriais e o radiômetro Bluephase II também foram utilizados para medir a energia dos fotopolimerizadores (mW). Os fotopolimerizadores foram ativados por 20 s (n=5). Os dados foram analisados utilizando Kruskal-Wallis e teste de Student-Newman-Keuls (a=0,05). Dentre os fotopolimerizadores, os instrumentos laboratoriais apresentaram diferentes valores de irradiância, exceto para o Corded VALO. O Coltolux e o Hilux mensuraram uma irradiância maior comparado aos instrumentos de laboratório para os quatro fotopolimerizadores testados. Para o mesmo fotopolimerizador, os radiômetros analógicos portáteis mensuraram menores valores de irradiância quando comparados aos digitais portáteis ou aos instrumentos laboratoriais, exceto quando utilizado o Spring para o Elipar S10. Nenhuma diferença foi observada entre os instrumentos laboratoriais na irradiância do Corded VALO. Para a medição da energia, nenhuma diferença foi observada usando Thermopile e a Integrating Sphere para o Corded VALO. Para os outros fotopolimerizadores, cada instrumento indicou uma energia diferente. Esses achados sugerem que radiômetros portáteis utilizados pelos cirurgiões-dentistas (analógico ou digital) exibem uma ampla gama de valores de irradiância e podem mostrar medidas inferiores comparados aos instrumentos de laboratório.

Abstract This study measured and compared exitance irradiance and power of 4 commercial dental light-curing units (LCU) (Elipar S10, Elipar DeepCure-S, Corded VALO and Bluephase Style) using different types of radiometers. The devices used to analyze the LCU were classified as either handheld analog (Henry Schein, Spring, Demetron 100A, Demetron 100B and Demetron 200), handheld digital (Bluephase 1, Bluephase II, Coltolux, CureRite and Hilux), or laboratory instruments (Thermopile and Integrating Sphere). The laboratory instruments and the Bluephase II radiometer were also used to measure the LCU’s power (mW). The LCU’s were activated for 20 s (n=5). Data were analyzed using Kruskal-Wallis and Student-Newman-Keuls multiple comparison test (a=0.05). Among the LCU, the laboratory instruments presented different irradiance values, except for Corded VALO. The Coltolux and Hilux radiometers measured greater irradiance values compared to the laboratory instruments for the four LCUs tested. Within a given LCU, handheld analog units measured lower irradiance values, compared to handheld digital and laboratory instruments, except using the Spring radiometer for the Elipar S10 LCU. None of the handheld radiometers were able to measure similar irradiance values compared to laboratory instruments, except for Elipar S10 when comparing Bluephase 1 and Thermopile. Regarding power measurement, Bluephase II always presented the lowest values compared to the laboratory instruments. These findings suggest that the handheld radiometers utilized by practitioners (analog or digital) exhibit a wide range of irradiance values and may show lower outcomes compared to laboratory based instruments.

https://doi.org/10.1590/0103-6440201902430 1345 downloads

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