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Translation into Portuguese (Brazil), cultural adaptation and validation of Parathyroid Assessment of Symptoms (PAS) in patients with chronic kidney disease and hyperparathyroidism Brazil, Brazil , (Brazil) PAS (PAS (Brazil
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Campos, Rafael Costa e

; Amaral, Rayssa Ruszkowski do

; Hentschke, Marta Ribeiro

; Toneto, Marcelo Garcia

; Poli-de-Figueiredo, Carlos Eduardo

Brazilian Journal of Nephrology

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Dez 2024, Volume 46 Nº 4 elocation e20220059

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Introdução: A doença renal crônica (DRC) está relacionada à elevada morbimortalidade e perda de qualidade de vida. Igualmente, o hiperparatireoidismo está associado à perda progressiva da função renal, com níveis aumentados de fosfato e diminuição de cálcio, que induzem secreção do paratormônio. Objetivos: Traduzir para língua portuguesa (Brasil), adaptar culturalmente e validar o questionário Parathyroid Symptoms Assessment (PAS), seguindo critérios de confiabilidade e validade em pacientes com DRC e hiperparatireoidismo. Métodos: Estudo metodológico e transversal, realizado no Hospital São Lucas/PUCRS, Porto Alegre, Brasil. O processo de validação do questionário PAS seguiu protocolos de estudos anteriores. Após tradução para o português, aplicou-se a 100 pacientes com hiperparatireoidismo secundário (HPTS) e terciário ou persistente (HPTT). Para dados de validação do PAS, os pacientes responderam ao questionário Short Form Health 36 (SF-36). Critérios de confiabilidade foram avaliados usando coeficiente de correlação intraclasse (CCI) e alfa de Cronbach (α-C). A validade foi avaliada pelo coeficiente de correlação de Spearman entre valores de PAS e SF-36. Resultados: A idade média dos participantes foi 55,6 ± 15,6 anos, 61% eram homens e 68% foram diagnosticados com HPTS. Entre 100 pacientes, 53% realizaram reteste de PAS (CCI = 0,83). A confiabilidade interna por α-C foi 0,86. Observaram-se correlações negativas entre questões do PAS e os domínios físico e mental do SF-36, que variaram de 0,3 a 0,7. Conclusão A versão brasileira do questionário PAS mostrou-se válida e confiável. O questionário PAS pode ser usado para avaliar qualidade de vida em pacientes brasileiros com hiperparatireoidismo que falam português. Introdução (DRC Igualmente cálcio paratormônio Objetivos Brasil, Brasil , (Brasil) (PAS) Métodos transversal LucasPUCRS Lucas PUCRS Lucas/PUCRS Alegre anteriores português aplicouse aplicou se 10 HPTS (HPTS HPTT. HPTT . (HPTT) 3 SF36. SF36 SF (SF-36) CCI αC. αC α C (α-C) 36. SF-36 Resultados 556 55 6 55, 156 15 15, anos 61 68 53 0,83. 083 0,83 0 83 0,83) 086 86 0,86 Observaramse Observaram SF36, 36, 03 0, 07 7 0,7 mostrouse mostrou confiável (Brasil (PAS 1 (HPTT SF3 (SF-36 (α-C SF-3 5 08 0,8 8 (SF-3 SF- (SF- (SF

Abstract Introduction: Chronic kidney disease (CKD) is related to high morbidity and mortality and loss of quality of life. Likewise, hyperparathyroidism is associated to progressive loss of renal function, with increased phosphate and decrease calcium levels, which induce the secretion of parathyroid hormone. Objectives: To translate into Portuguese (Brazil), culturally adapt and validate the questionnaire Parathyroid Symptoms Assessment (PAS), following reliability and validity criteria in patients with chronic kidney disease and hyperparathyroidism. Methods: Methodological and cross-sectional study, carried out at São Lucas Hospital/PUCRS, Porto Alegre, Brazil. The PAS questionnaire validation process followed protocols from previous studies. After translating into Portuguese, it was applied to 100 patients with secondary (SHPT) and tertiary or persistent (THPT) hyperparathyroidism. For PAS validation data, patients responded to the Short Form Health 36 (SF-36) questionnaire. Reliability criteria were evaluated using intraclass correlation coefficient (ICC) and Cronbach’s alpha (α-C). Validity was assessed by Spearman’s correlation coefficient between PAS and SF-36 values. Results: Participant’s mean age was 55.6 ± 15.6 years, 61% was male, and 68% was diagnosed with SHPT. Among 100 patients, 53% performed a PAS retest (ICC = 0.83). The internal reliability by α-C was 0.86. Negative correlations were observed between PAS questions and SF-36 physical and mental domains, which ranged from 0.3 to 0.7. Conclusion: The Brazilian version of the PAS questionnaire was found to be valid and reliable. The PAS questionnaire can be used to evaluate quality of life in Brazilian patients with hyperparathyroidism who speak Portuguese. Introduction CKD (CKD Likewise function levels hormone Objectives Brazil, Brazil , (Brazil) PAS, (PAS) Methods crosssectional cross sectional study HospitalPUCRS Hospital PUCRS Hospital/PUCRS Alegre studies 10 SHPT (SHPT THPT (THPT data 3 SF36 SF (SF-36 ICC Cronbachs Cronbach s αC. αC α C . (α-C) Spearmans Spearman SF-3 values Results Participants Participant 556 55 6 55. 156 15 15. years 61 male 68 53 0.83. 083 0.83 0 83 0.83) 086 86 0.86 domains 03 0. 07 7 0.7 Conclusion reliable (Brazil (PAS 1 SF3 (SF-3 (α-C SF- 5 08 0.8 8 (SF- (SF

https://doi.org/10.1590/2175-8239-jbn-2022-0059en

Profile of Surgeons Who Treat Inflammatory Bowel Diseases in Brazil
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Zabot, Gilmara Pandolfo

; Cassol, Ornella Sari

; Vilela, Eduardo Garcia

; Alves Junior, Antônio José Tibúrcio

; Silva, Daniel de Castilho da

; Saad-Hossne, Rogério

Journal of Coloproctology (Rio de Janeiro)

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2024, Volume 44 Nº 1 Páginas e53 - e62

Resumo: En | Texto: En | PDF: En

Abstract Objective To describe the pro file of surgeons who treat patients with inflammatory bowel disease as well as the characteristics of inflammatory bowel disease care, unmet demands, and difficulties. Methods The research participants answered a Google Forms questionnaire. Results Of the 99 surgeons who participated in the survey, 84.5% were coloproctologists, 40% were from the southeastern region of Brazil, and 77.7% were male and had been working for more than 19 years. Regarding the healthcare sector, 63.6% of surgeons worked in both public and private clinics, and most clinically cared for up to 50 patients with inflammatory bowel disease and operated on up to 5 cases per year. Conclusion This is the first national study that aimed to identify the profile of surgeons working with inflammatory bowel disease in Brazil. The vast majority are experienced male coloproctologists, located in the southern and southeastern regions, who perform clinical and surgical treatment of these pathologies, with major surgeries being performed in large centers by a small number of surgeons. care demands difficulties questionnaire 9 survey 845 84 84.5 coloproctologists 40 Brazil 777 77 7 77.7 1 years sector 636 63 6 63.6 clinics year regions pathologies 8 84. 4 77. 63.

https://doi.org/10.1055/s-0044-1782153

Accuracy of the Verbal Autopsy questionnaire in the diagnosis of COVID-19 deaths in a Brazilian capital COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Campos, Marcos Adriano Garcia

; Cutrim, Ézio Arthur Monteiro

; Cutrim, Érico Murilo Monteiro

; Oliveira, João Victor Pimentel de

; Oliveira, Eduardo José Silva Gomes de

; Pontes, Daniel de Brito

; Figueiredo Neto, José Albuquerque de

; Silva, Gyl Eanes Barros

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e33

Resumo: En | Texto: En | PDF: En

ABSTRACT The Verbal Autopsy (VA) is a questionnaire about the circumstances surrounding a death. It was widely used in Brazil to assist in postmortem diagnoses and investigate excess mortality during the Coronavirus Disease 2019 (COVID-19) pandemic. This study aimed to determine the accuracy of investigating acute respiratory distress syndrome (ARDS) using VA. This is a cross-sectional study with prospective data collected from January 2020 to August 2021 at the Death Verification Service of Sao Luis city, Brazil. VA was performed for suspected COVID-19 deaths, and one day of the week was randomly chosen to collect samples from patients without suspected COVID-19. Two swabs were collected after death and subjected to reverse transcription-polymerase chain reaction (RT-PCR) for SARS-CoV-2 detection. Of the 250 cases included, the VA questionnaire identified COVID-19-related ARDS in 67.2% (52.98% were positive for COVID-19). The sensitivity of the VA questionnaire was 0.53 (0.45–0.61), the specificity was 0.75 (0.64–0.84), the positive predictive value was 0.81 (0.72–0.88), and the negative predictive value was 0.44 (0.36–0.53). The VA had a lower-than-expected accuracy for detecting COVID-19 deaths; however, because it is an easily accessible and cost-effective tool, it can be combined with more accurate methods to improve its performance. (VA 201 COVID19 COVID 19 (COVID-19 pandemic (ARDS crosssectional cross sectional 202 city COVID-1 deaths COVID19. 19. transcriptionpolymerase transcription polymerase RTPCR RT PCR (RT-PCR SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- detection 25 included COVID19related COVIDrelated related 672 67 67.2 52.98% 5298 52 98 (52.98 . COVID-19) 053 0 53 0.5 0.45–0.61, 045061 0.45–0.61 , 45 61 (0.45–0.61) 075 75 0.7 0.64–0.84, 064084 0.64–0.84 64 84 (0.64–0.84) 081 81 0.8 0.72–0.88, 072088 0.72–0.88 72 88 (0.72–0.88) 044 44 0.4 0.36–0.53. 036053 0.36–0.53 36 (0.36–0.53) lowerthanexpected lower than expected however costeffective cost effective tool performance 20 COVID1 1 (COVID-1 COVID- SARS-CoV 6 67. 52.98 529 5 9 (52.9 05 0. 04506 0.45–0.6 4 (0.45–0.61 07 7 06408 0.64–0.8 8 (0.64–0.84 08 07208 0.72–0.8 (0.72–0.88 04 03605 0.36–0.5 3 (0.36–0.53 (COVID- 52.9 (52. 0450 0.45–0. (0.45–0.6 0640 0.64–0. (0.64–0.8 0720 0.72–0. (0.72–0.8 0360 0.36–0. (0.36–0.5 (COVID 52. (52 045 0.45–0 (0.45–0. 064 0.64–0 (0.64–0. 072 0.72–0 (0.72–0. 036 0.36–0 (0.36–0. (5 0.45– (0.45–0 06 0.64– (0.64–0 0.72– (0.72–0 03 0.36– (0.36–0 ( 0.45 (0.45– 0.64 (0.64– 0.72 (0.72– 0.36 (0.36– (0.45 0.6 (0.64 (0.72 0.3 (0.36 (0.4 (0.6 (0.7 (0.3 (0. (0

https://doi.org/10.1590/s1678-9946202466033

Exploring the relationship between SARS-CoV-2 infection and headache: comprehensive systematic review SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- headache SARS-CoV
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Dutra, Guilherme

; Martins, Felipe

; Chaves, Eduardo Trota

; Torino, Gabriela Garcia

; Boscato, Noéli

BrJP

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2024, Volume 7 elocation e20240027

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT BACKGROUND AND OBJECTIVES: Addressing secondary headaches in SARS-CoV-2 infection is crucial for effective management and care optimization. This review aims to synthesize data on headache characteristics and the impact of pre-existing headache conditions on these symptoms in SARS-CoV-2 infection. CONTENTS: A systematic search was conducted across multiple databases, including PubMed/Medline, Cochrane Collaboration, Web of Science, Scopus, LILACS, Embase, Open Grey, and Google Scholar, to identify studies on headache characteristics associated with SARS-CoV-2. The search focused on headache symptoms, characteristics, onset, duration, and response to treatment during and post-infection. Twenty-three studies met the inclusion criteria. Approximately 42.1% of individuals with SARS-CoV-2 reported headaches, resembling tension-type headaches and migraines. These headaches often manifested within the first three days of infection and could persist for up to four months. The data suggest that trigeminovascular activation and pro-inflammatory mediators play a significant role in headache pathogenesis, with pre-existing headache conditions exacerbating the symptoms. The importance of effective pain management strategies must be emphasized. CONCLUSION: Headache is a prevalent symptom among SARS-CoV-2 infected individuals, with significant implications for patient care. The findings emphasize the importance of recognizing headache characteristics in SARS-CoV-2 management and suggest that tailored clinical approaches are essential for effective symptom relief. OBJECTIVES SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- optimization preexisting pre existing CONTENTS databases PubMedMedline PubMed Medline PubMed/Medline Collaboration Science Scopus LILACS Embase Grey Scholar SARSCoV2. 2. onset duration postinfection. postinfection post post-infection Twentythree Twenty criteria 421 42 1 42.1 tensiontype tension type migraines months proinflammatory pro inflammatory pathogenesis emphasized CONCLUSION relief SARS-CoV 4 42.

RESUMO JUSTIFICATIVA E OBJETIVOS: A abordagem das cefaleias secundárias na infecção pela SARS-CoV-2 é crucial para um manejo adequado e otimização do cuidado. Esta revisão tem como objetivo sintetizar os dados sobre as características da cefaleia e o impacto das condições pré-existentes de cefaleia sobre esses sintomas na infecção pela SARS-CoV-2. CONTEÚDO: Uma pesquisa sistemática foi realizada em vários bancos de dados, incluindo: Pubmed/Medline, Cochrane Collaboration, Web of Science, Scopus, LILACS, Embase, Open Grey e Google Scholar, com o objetivo de identificar estudos sobre as características da cefaleia associadas à SARS-CoV-2. A pesquisa se concentrou nos sintomas, nas características, no início, na duração e na resposta ao tratamento da cefaleia durante e após a infecção. Vinte e três estudos atenderam aos critérios de inclusão. Aproximadamente 42,1% dos indivíduos com SARS-CoV-2 relataram dores de cabeça, semelhantes a dores de cabeça do tipo tensional e enxaquecas. Essas cefaleias geralmente se manifestavam nos primeiros três dias de infecção e podiam persistir por até quatro meses. Os dados sugerem que a ativação trigeminovascular e os mediadores pró-inflamatórios desempenham um papel importante na patogênese da cefaleia, com condições preexistentes de cefaleia exacerbando os sintomas. A importância de estratégias eficazes de controle da dor deve ser enfatizada. CONCLUSÃO: A cefaleia é um sintoma prevalente entre os indivíduos infectados pela SARS-CoV-2, com significativas implicações no atendimento ao paciente. Os achados deste estudo enfatizam a importância do reconhecimento das características da cefaleia no manejo da SARS-CoV-2 e sugerem que abordagens clínicas personalizadas são essenciais para o alívio eficaz dos sintomas. OBJETIVOS SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- cuidado préexistentes pré existentes SARSCoV2. 2. CONTEÚDO incluindo PubmedMedline Pubmed Medline Pubmed/Medline Collaboration Science Scopus LILACS Embase Scholar início inclusão 421 42 1 42,1 enxaquecas meses próinflamatórios pró inflamatórios enfatizada CONCLUSÃO SARSCoV2, 2, paciente SARS-CoV 4 42,

https://doi.org/10.5935/2595-0118.20240027-en

Risks of technological advance and the Anthropocene feedback process in energy and agriculture
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Bezerra, Marcio Eduardo Garcia

; Marquesan, Fábio Freitas Schilling

; Figueiredo, Marina Dantas de

RAM. Revista de Administração Mackenzie

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2024, Volume 25 Nº 4 elocation eRAMG240015

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Purpose: This article aims to highlight the existence of an Anthropocene feedback process originating from the pressures of human actions on Earth, particularly the adoption of novel technologies that bring risks and negative environmental impacts in two strategic economic sectors: energy and agriculture. Originality/value: We defend the argument that each technological advance generates new associated risks, increasing the negative pressure on terrestrial ecosystems. This argument draws inspiration from the discourse on the “risk society” (Beck, 2011), which deals with the unquantified uncertainties linked to technological progress. It also aligns with the concept of the Anthropocene (Crutzen & Stoermer, 2000), which examines how human actions and organizations impact the Earth’s system. The discussions demonstrate that uncertainty remains an inherent facet of human activities, thus perpetually subjecting such actions to risk. Design/methodology/approach: We employ a theoretical essay approach to discuss evidence that underscores the challenges posed by technological advancements in the energy and agriculture sectors, notably expressing human-induced environmental impacts. Findings: By analyzing technological advances in energy and agriculture, we substantiate the existence of the Anthropocene feedback process. This analysis contradicts the notion of a favorable “good Anthropocene” (Asafu-Adjaye et al., 2015) and challenges the misconception that technological progress alone can sufficiently mitigate the repercussions of human activities on Earth. Purpose Earth sectors Originality/value Originalityvalue Originality value ecosystems risk society Beck, Beck (Beck 2011, 2011 , 2011) Crutzen Stoermer 2000, 2000 2000) Earths s system Design/methodology/approach Designmethodologyapproach Design methodology humaninduced induced Findings good AsafuAdjaye Asafu Adjaye al al. 2015 201 200 20 2

Resumo Objetivo: Este artigo visa evidenciar a existência de um processo de retroalimentação do Antropoceno, cuja origem está nas pressões das ações humanas sobre a Terra, tomando por base a adoção de novas tecnologias que trazem riscos e impactos negativos ao meio ambiente em dois setores econômicos estratégicos: energia e agricultura. Originalidade/valor: Defendemos o argumento de que cada avanço tecnológico gera novos riscos associados, o que tende a aumentar a pressão negativa sobre os diferentes ecossistemas terrestres. Tal argumento está fundamentado em discussões sobre a “sociedade de risco” (Beck, 2011), que trata das incertezas não quantificadas dos riscos inerentes ao progresso técnico, e sobre o Antropoceno (Crutzen & Stoermer, 2000), em torno dos processos pelos quais a humanidade e suas organizações impactam o Sistema-Terra. A partir dessas discussões, entendemos que não se pode excluir totalmente a incerteza das ações humanas e, portanto, tal ação estará sempre sujeita a uma condição de risco. Design/metodologia/abordagem: A partir de um ensaio teórico, são debatidas evidências da problemática dos avanços tecnológicos nesses setores, considerados particularmente expressivos dos impactos humanos no ambiente. Resultados: As evidências do processo de retroalimentação do Antropoceno por meio da análise dos avanços tecnológicos nos setores de energia e agricultura subsidiam uma reflexão contrária à ideia de que existiria um “bom Antropoceno” (Asafu-Adjaye et al., 2015) e expõem a falácia de que o avanço tecnológico dá conta de frear os impactos das ações humanas no planeta Terra. Objetivo Terra estratégicos Originalidade/valor Originalidadevalor Originalidade valor associados terrestres sociedade risco Beck, Beck (Beck 2011, 2011 , 2011) técnico Crutzen Stoermer 2000, 2000 2000) SistemaTerra. SistemaTerra Sistema Sistema-Terra portanto Design/metodologia/abordagem Designmetodologiaabordagem Design metodologia abordagem teórico Resultados bom AsafuAdjaye Asafu Adjaye al al. 2015 201 200 20 2

https://doi.org/10.1590/1678-6971/eramg240015

Biomarkers and prediction of anthracyclic cardiotoxicity in breast cancer
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Silva, Eduardo Nani

; Ribeiro, Mario Luiz

; Caldeira, Lilian Campos

; Jorge, Antonio José Lagoeiro

; Rosa, Maria Luiza Garcia

; Mesquita, Evandro Tinoco

; Villacorta, Humberto

; Martins, Wolney de Andrade

Revista da Associação Médica Brasileira

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2024, Volume 70 Supl. 1 elocation e2024S106

Resumo: En | Texto: En | PDF: En

SUMMARY BACKGROUND: Chemotherapy with doxorubicin may lead to left ventricular dysfunction. There is a controversial recommendation that biomarkers can predict ventricular dysfunction, which is one of the most feared manifestations of anthracycline cardiotoxicity. OBJECTIVE: The aim of this study was to evaluate the behavior of biomarkers such as Troponin I, type B natriuretic peptide, creatine phosphokinase fraction MB, and myoglobin in predicting cardiotoxicity in a cohort of women with breast cancer undergoing chemotherapy with anthracycline. METHODS: This is an observational, prospective, longitudinal, unicentric study, which included 40 women with breast cancer, whose therapeutic proposal included treatment with doxorubicin. The protocol had a clinical follow-up of 12 months. Biomarkers such as Troponin I, type B natriuretic peptide, creatine phosphokinase fraction MB, and myoglobin were measured pre-chemotherapy and after the first, third, fourth, and sixth cycles of chemotherapy. RESULTS: There was a progressive increase in type B natriuretic peptide and myoglobin values in all chemotherapy cycles. Although creatine phosphokinase fraction MB showed a sustained increase, this increase was not statistically significant. Troponin, type B natriuretic peptide, myoglobin, and creatine phosphokinase fraction MB were the cardiotoxicity markers with the earliest changes, with a significant increase after the first chemotherapy session. However, they were not able to predict cardiotoxicity. CONCLUSION: Troponin I, type B natriuretic peptide, myoglobin, and creatine phosphokinase fraction MB are elevated during chemotherapy with doxorubicin, but they were not able to predict cardiotoxicity according to established clinical and echocardiographic criteria. The incidence of subclinical cardiotoxicity resulting from the administration of doxorubicin was 12.5%. BACKGROUND dysfunction OBJECTIVE I METHODS observational prospective longitudinal 4 followup follow up 1 months prechemotherapy pre third fourth RESULTS changes session However CONCLUSION criteria 125 5 12.5% 12.5 12.

https://doi.org/10.1590/1806-9282.2024s106

Inhibitory potential of bioactive extracts from southern Brazil mushrooms on the pathogenic oomycete Pythium insidiosum
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Melo, Luíze Garcia de

; Braga, Caroline Quintana

; Bermann, Carolina dos Santos

; Morales, Diuliani Fonseca

; Volcão, Lisiane Martins

; Bernardi, Eduardo

; Botton, Sônia de Avila

; Pereira, Daniela Isabel Brayer

Ciência Rural

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2024, Volume 54 Nº 10 elocation e20230528

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT: Pythium insidiosum is an important oomycete pathogen of mammals that causes pythiosis, an endemic disease in warm climates that stands out for its unfavorable prognosis, lethality in the affected species, and difficulties in treatment. This study evaluated in vitro anti-P. insidiosum potential of aqueous, hydroethanolic, and ethanolic extracts of indigenous wild mushrooms from southern Brazil. The extracts were prepared from Amanita gemmata, Amanita muscaria, Auricularia auricula, Gymnopilus junonius, Lactarius deliciosus, Laccaria laccata, Psilocybe cubensis, and Russula xerampelina. In vitro susceptibility assays employed the microdilution technique according to the M38-A2 protocol CLSI. The hydroethanolic and ethanolic extracts of R. xerampelina showed anti-P. insidiosum activity at minimum inhibitory concentrations ranging from 1.87-7.50 mg/mL. The other mushroom species extracts showed no inhibitory effects on growth of P. insidiosum. This is the first study to evaluate the antimicrobial activity of mushrooms on oomycetes, evidencing the antimicrobial potential of R. xerampelina on the pathogen P. insidiosum. So, the present study expands new perspectives, since the secondary metabolites produced by mushrooms can be potential targets for the development of new categories of medicines. However, considering the wide biodiversity of Brazilian mushrooms, we suggested that the search for other basidiomycetes species with anti-P. insidiosum action needs to be expanded. ABSTRACT pythiosis prognosis treatment antiP. antiP anti P anti-P aqueous Brazil gemmata muscaria auricula junonius deliciosus laccata cubensis M38A2 MA M38 A2 M A M38-A CLSI R 1.877.50 187750 1.87 7.50 1 87 7 50 1.87-7.5 mgmL mg mL mg/mL oomycetes So perspectives medicines However expanded M38A M3 877 1.877.5 18775 187 1.8 750 7.5 8 5 1.87-7. 1.877. 1877 18 1. 75 7. 1.87-7 1.877 1.87-

RESUMO: Pythium insidiosum é um importante oomiceto patógeno de mamíferos causador da pitiose, uma doença endêmica em climas quentes e que se destaca pelo prognóstico desfavorável, letalidade nas espécies afetadas e dificuldades no tratamento. Este estudo avaliou in vitro o potencial anti-P. insidiosum dos extratos aquosos, hidroetanólicos e etanólicos de cogumelos silvestres do sul do Brasil. Os extratos foram preparados a partir de Amanita gemmata, Amanita muscaria, Auricularia auricula, Gymnopilus junonius, Lactarius deliciosus, Laccaria laccata, Psilocybe cubensis e Russula xerampelina. Os ensaios de suscetibilidade in vitro empregaram a técnica de microdiluição em caldo de acordo com o protocolo M38-A2, CLSI. Os extratos hidroetanólico e etanólico de R. xerampelina apresentaram atividade anti-P. insidiosum em concentrações inibitórias mínimas que variaram de 1,87-7,50 mg/mL. Os extratos das demais espécies de cogumelos não apresentaram efeitos inibitórios sobre o crescimento de P. insidiosum. Este é o primeiro estudo a avaliar a atividade antimicrobiana de cogumelos sobre oomicetos, evidenciando o potencial antimicrobiano de R. xerampelina sobre o patógeno P. insidiosum. Assim, o presente estudo amplia novas perspectivas, uma vez que os metabólitos secundários produzidos pelos cogumelos podem ser alvos potenciais para o desenvolvimento de novas categorias de fármacos. Porém, levando em consideração a ampla biodiversidade de cogumelos brasileiros, sugere-se que a busca por outras espécies de basidiomicetos com atividade anti-P. insidiosum precisa ser ampliada. RESUMO pitiose desfavorável tratamento antiP. antiP anti P anti-P aquosos Brasil gemmata muscaria auricula junonius deliciosus laccata M38A2, M38A2 MA M38 A2, A2 M A M38-A2 CLSI R 1,877,50 187750 1,87 7,50 1 87 7 50 1,87-7,5 mgmL mg mL mg/mL oomicetos Assim perspectivas fármacos Porém brasileiros sugerese sugere ampliada M38A M3 M38-A 877 1,877,5 18775 187 1,8 750 7,5 8 5 1,87-7, 1,877, 1877 18 1, 75 7, 1,87-7 1,877 1,87-

https://doi.org/10.1590/0103-8478cr20230528

Diretriz de Tomografia Computadorizada e Ressonância Magnética Cardiovascular da Sociedade Brasileira de Cardiologia e do Colégio Brasileiro de Radiologia – 2024 202 20 2
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Magalhães, Tiago Augusto

; Carneiro, Adriano Camargo de Castro

; Moreira, Valéria de Melo

; Trad, Henrique Simão

; Lopes, Marly Maria Uellendahl

; Cerci, Rodrigo Julio

; Nacif, Marcelo Souto

; Schvartzman, Paulo R.

; Chagas, Antônio Carlos Palandrini

; Costa, Isabela Bispo Santos da Silva

; Schmidt, André

; Shiozaki, Afonso Akio

; Montenegro, Sérgio Tavares

; Piegas, Leopoldo Soares

; Zapparoli, Marcelo

; Nicolau, José Carlos

; Fernandes, Fabio

; Hadlich, Marcelo Souza

; Ghorayeb, Nabil

; Mesquita, Evandro Tinoco

; Gonçalves, Luiz Flávio Galvão

; Ramires, Felix José Alvarez

; Fernandes, Juliano de Lara

; Schwartzmann, Pedro Vellosa

; Rassi, Salvador

; Torreão, Jorge Andion

; Mateos, José Carlos Pachón

; Beck-da-Silva, Luiz

; Silva, Marly Conceição

; Liberato, Gabriela

; Oliveira, Gláucia Maria Moraes de

; Feitosa Filho, Gilson Soares

; Carvalho, Hilka dos Santos Moraes de

; Markman Filho, Brivaldo

; Rocha, Ricardo Paulo de Sousa

; Azevedo Filho, Clerio Francisco de

; Taratsoutchi, Flávio

; Coelho-Filho, Otavio Rizzi

; Kalil Filho, Roberto

; Hajjar, Ludhmila Abrahão

; Ishikawa, Walther Yoshiharu

; Melo, Cíntia Acosta

; Jatene, Ieda Biscegli

; Albuquerque, Andrei Skromov de

; Rimkus, Carolina de Medeiros

; Silva, Paulo Savoia Dias da

; Vieira, Thiago Dieb Ristum

; Jatene, Fabio Biscegli

; Azevedo, Guilherme Sant Anna Antunes de

; Santos, Raul D.

; Monte, Guilherme Urpia

; Ramires, José Antonio Franchini

; Bittencourt, Marcio Sommer

; Avezum, Alvaro

; Silva, Leonardo Sara da

; Abizaid, Alexandre

; Gottlieb, Ilan

; Precoma, Dalton Bertolim

; Szarf, Gilberto

; Sousa, Antônio Carlos Sobral

; Pinto, Ibraim Masciarelli Francisco

; Medeiros, Fábio de Morais

; Caramelli, Bruno

; Parga Filho, José Rodrigues

; Santos, Tiago Senra Garcia dos

; Prazeres, Carlos Eduardo Elias dos

; Lopes, Marcelo Antonio Cartaxo Queiroga

; Avila, Luiz Francisco Rodrigues de

; Scanavacca, Mauricio Ibrahim

; Gowdak, Luis Henrique Wolff

; Barberato, Silvio Henrique

; Nomura, Cesar Higa

; Rochitte, Carlos Eduardo

Arquivos Brasileiros de Cardiologia

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2024, Volume 121 Nº 9 elocation e20240608

Resumo: Pt | Texto: Pt | PDF: Pt

https://doi.org/10.36660/abc.20240608

Efecto de la combinación de jugos naturales en la osmolalidad de una bebida hipertónica
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Molina Borja, Franklin Antonio

; Saldaña San Martín, Britany Kristel

; Rojas Molina, Jaime Orlando

; Garcia Noa, Eduardo Julio

; Garcia Pérez, Mario A.

Revista Universidad y Sociedad

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Out 2023, Volume 15 Nº 5 Páginas 376 - 394

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN En la Universidad Técnica de Cotopaxi, Ecuador se estudió el efecto de la Osmolalidad en una bebida hipertónica a partir de la combinación de jugo de naranja y jugo de zanahoria, aplicando una investigación experimental. Se elaboro 13 diferentes tratamientos que se establecieron con el programa estadístico Design Expert 11.1.0.1 (StadEase Inc., Minneapolis, EE.UU.). Las muestras fueron sometidas a una previa pasteurización para su posterior envasado. Se realizó una evaluación sensorial, en donde se determinó a los tratamientos 1, 8 y 13 como los más aceptados. Posteriormente mediante el programa se obtuvo la corrida experimental más optima en cuanto a la osmolalidad que determinó como el mejor tratamiento al t8 que corresponde a la formulación con un mix de sales de 0,25 %; agua 15 %; jugo de naranja 54,11 % y jugo de zanahoria 30,64 %, dando así una osmolalidad de 487 mOsm/Kg. En el análisis fisicoquímico, se obtuvieron los siguientes resultados: pH de 5; 0,64 de acidez;7,8 °Brix y 1,038 g/ml de densidad; análisis microbiológico de Mohos, Levaduras, E. Coli y Coliformes Totales dichos resultados son <1 y en nutricionales tenemos por cada 250 ml; 9 % de sodio; 7 % carbohidratos; 8,37 % azúcares totales; 9,85 % sólidos totales; 0,38 % proteínas; 37,42 kcal/100 g; 0,17 mg/100 g vitamina A; 0,002 mg/100 g vitamina B3 y 17,06 mg/100 g vitamina C %. El costo de esta bebida fue de 0,79 centavos de dólar para 500 ml y de 0,39 centavos de dólar para 250 ml.

SUMMARY At the Technical University of Cotopaxi, Ecuador, the effect of Osmolality in a hypertonic drink from the combination of orange juice and carrot juice was studied, applying an experimental investigation. Thirteen different treatments were developed and established with the statistical program Design Expert 11.1.0.1 (StadEase Inc., Minneapolis, USA). The samples were subjected to a previous pasteurization for their subsequent packaging. A sensory evaluation was carried out, where treatments 1, 8 and 13 were determined as the most accepted. Subsequently, through the program, the most optimal experimental run was obtained in terms of osmolality, which was determined as the best treatment at t8 that corresponds to the formulation with a mix of salts of 0.25%; water 15%; 54.11% orange juice and 30.64% carrot juice, thus giving an osmolality of 487 mOsm/Kg. In the physicochemical analysis, the following results were obtained: pH of 5; 0.64 acidity; 7.8 °Brix and 1.038 g/ml density; microbiological analysis of Moulds, Yeasts, E. Coli and Total Coliforms, said results are <1 and in nutritionals we have per-250 ml; 9% sodium; 7% carbs; 8.37% total sugars; 9.85% total solids; 0.38% protein; 37.42 kcal/100 g; 0.17 mg/100 g vitamin A; 0.002 mg/100 g vitamin B3 and 17.06 mg/100 g vitamin C %. The cost of this drink was 0.79 US cents for 500 ml and 0.39 US cents for 250 ml.

10.

CLINICAL OUTCOME AND SEVERITY OF CLOSTRIDIOIDES (CLOSTRIDIUM) DIFFICILE INFECTION AT A TERTIARY REFERRAL HOSPITAL IN BRAZIL CLOSTRIDIUM (CLOSTRIDIUM
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CARVALHO, Fernando Antônio Castro

; SILVA, Rodrigo Otávio Silveira

; SANTOS, Bárbara Moreira Ribeiro Trindade dos

; DINIZ, Amanda Nádia

; VILELA, Eduardo Garcia

Arquivos de Gastroenterologia

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Set 2023, Volume 60 Nº 3 Páginas 330 - 338

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Background: Clostridioides difficile infection (CDI) is a potentially severe disease that can present with refractoriness, recurrence, and evolution to death. In Brazil, the epidemiology of CDI seems to differ from that of the United States and most European countries, with only one ribotype (RT) 027-related case and a high prevalence of RT106. Objective: The aim of this study was to evaluate the outcomes of CDI and its possible association with ribotypes at a university hospital in Brazil. Methods: A total of 65 patients with CDI were included and stool samples were submitted to A/B toxin detection and toxigenic culture, and toxigenic isolates (n=44) were also PCR ribotyped. Results: Patients’ median age was 59 (20-87) years and there were 16 (24.6%) deaths. The median Charlson comorbidity index (CCI) was 4 (0-15) and 16.9% of the patients had CCI ≥8. The ATLAS score and non-improvement of diarrhea were related to higher mortality. A longer length of hospitalization was related to the enteral nutrition and use of multiple antibiotics. The period between CDI diagnosis and hospital discharge was longer in those who received new antibiotics after diagnosis, multiple antibiotics, and required intensive care treatment. Recurrence was associated with CCI >7. Twenty ribotypes were identified and RT106 was the most frequently detected strain (43.2%). No relationship was observed between the ribotypes and outcomes. CDI was present in patients with more comorbidities. Conclusion: Risk factors for higher mortality, longer hospital stay and recurrence were identified. A diversity of ribotypes was observed and C. difficile strains were not related to the outcomes. Background (CDI refractoriness death Brazil countries RT (RT 027related 027 Objective Methods 6 AB B culture n=44 n44 n 44 (n=44 ribotyped Results Patients 5 2087 20 87 (20-87 1 24.6% 246 24 (24.6% deaths (CCI 015 0 15 (0-15 169 9 16.9 8 ≥8 nonimprovement non improvement mortality treatment 7 >7 RT10 43.2%. 432 43.2% . 43 2 (43.2%) comorbidities Conclusion C 02 n=4 n4 (n=4 208 (20-8 24.6 (24.6 01 (0-1 16. ≥ > RT1 43.2 (43.2% n= (n= (20- 24. (24. (0- 43. (43.2 (n (20 (24 (0 (43. (2 ( (43 (4

RESUMO Contexto: A infecção pelo Clostridioides difficile (ICD) é uma doença potencialmente grave que pode se apresentar com refratariedade, recidiva e evoluir para óbito. No Brasil, a epidemiologia da ICD parece diferir da dos Estados Unidos e da maioria dos países europeus, com apenas um caso relacionado ao ribotipo (RT) 027 e alta prevalência do RT106. Objetivo: Avaliar os desfechos da ICD e sua possível associação com ribotipos em um hospital universitário do Brasil. Métodos: Um total de 65 pacientes com ICD foram incluídos e amostras de fezes foram submetidas à detecção de toxina A/B e cultura toxigênica e as cepas toxigênicas isoladas (n=44) também foram ribotipadas por PCR. Resultados: A idade mediana dos pacientes foi de 59 (20-87) anos e houve 16 (24,6%) óbitos. A mediana do índice de comorbidade de Charlson (ICC) foi de 4 (0-15) e 16,9% dos pacientes apresentaram ICC ≥8. O escore ATLAS e a não melhora da diarreia foram relacionados a maior mortalidade. Maior tempo de internação esteve relacionado à nutrição enteral e ao uso de múltiplos antibióticos. O período entre o diagnóstico de ICD e a alta hospitalar foi maior naqueles que receberam novos antibióticos após o diagnóstico, múltiplos antibióticos e necessitaram de tratamento intensivo. A recorrência foi associada com ICC >7. Vinte ribotipos foram identificados e o RT106 foi a cepa mais frequentemente detectada (43,2%). Não foi observada relação entre os ribotipos e os desfechos. ICD esteve presente em pacientes com mais comorbidades. Conclusão: Foram identificados fatores de risco para maior mortalidade, maior tempo de internação e recorrência. Uma diversidade de ribotipos foi observada e cepas de C. difficile não foram relacionadas aos desfechos. Contexto (ICD refratariedade óbito Brasil europeus RT (RT 02 Objetivo Métodos 6 AB B n=44 n44 n 44 (n=44 PCR Resultados 5 2087 20 87 (20-87 1 24,6% 246 24 (24,6% óbitos (ICC 015 0 15 (0-15 169 9 16,9 8 ≥8 mortalidade intensivo 7 >7 RT10 43,2%. 432 43,2% . 43 2 (43,2%) comorbidades Conclusão C n=4 n4 (n=4 208 (20-8 24,6 (24,6 01 (0-1 16, ≥ > RT1 43,2 (43,2% n= (n= (20- 24, (24, (0- 43, (43,2 (n (20 (24 (0 (43, (2 ( (43 (4

https://doi.org/10.1590/s0004-2803.230302023-36

11.

DNA rare copy number alterations in Reinke’s Edema Reinkes Reinke s
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Móz, Luis Eduardo Silva

; Martins, Regina Helena Garcia

; Lapa, Rainer Marco Lopez

; Villacis, Rolando André Rios

; Reis, Patricia Pintor dos

; Rogatto, Silvia Regina

Brazilian Journal of Otorhinolaryngology

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Abr 2023, Volume 89 Nº 2 Páginas 279 - 284

Resumo: En | Texto: En | PDF: En

Abstract Introduction: Reinke’s Edema (RE) is a laryngeal lesion related to excessive tobacco smoking, voice overuse, and laryngopharyngeal reflux. Although the risk of malignancy has been considered low in literature, RE is classified among precancerous lesions. Objectives: We investigated DNA Copy Number Alterations (CNAs) in specimens of RE and its potential association with malignant progression. Methods: We used array-based comparative genomic hybridization (aCGH, Agilent 4 × 180 K platform) to study eight RE cases. All patients were heavy tobacco users for at least 30 years, and none of them progressed to cancer in the follow-up (>8 years). Two RE presented mild dysplasia, one moderate dysplasia, and no histological alterations were found in the remaining five cases. CNAs were compared with the Database of Genomic Variants (DGV) and genes mapped on altered regions had their functions annotated. Results: Six of eight patients showed different rare copy number alterations on chromosomes 2q37.3, 4q13.1, 4q13.3, 7q11.22, 10p14, and 13q34. A gain of the whole chromosome 8 were detected in one case. Of interest, four of eight RE cases showed copy number imbalances involving genes previously described in several tumor types (RASA3, COL6A3, LINC00707, LINP1, SMR3A, and SMR3B). Conclusion: The genomic imbalances herein found in RE have the potential to contribute to the phenotype but with limited or no risk of cancer. A long-term follow-up in a large series of patients could clarify the mechanisms involved in the malignant progression of RE. Level of evidence: 4. Introduction Reinkes Reinke s (RE smoking overuse reflux literature lesions Objectives (CNAs Methods arraybased array based aCGH, aCGH (aCGH 18 platform 3 years followup follow up >8 (> years. . years) dysplasia DGV (DGV annotated Results 2q373 q 2q37 2q37.3 4q131 4q13 1 4q13.1 4q133 4q13.3 7q1122 7q11 22 7q11.22 10p14 p 13q34 case interest RASA3, RASA3 RASA (RASA3 COL6A3 COLA COL LINC00707 LINC LINP1 LINP SMR3A SMRA SMR SMR3B. SMR3B SMRB B SMR3B) Conclusion longterm long term evidence > ( 2q3 2q37. 4q1 4q13. 7q112 7q1 2 7q11.2 10p1 13q3 (RASA COL6A LINC0070 2q 4q 7q 7q11. 10p 13q LINC007 LINC00 LINC0

https://doi.org/10.1016/j.bjorl.2022.09.002

12.

High-throughput phenotyping as an auxiliary tool in the selection of corn hybrids for agronomic traits Highthroughput High throughput
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Alcântara, Júlia Ferreira de

; Santos, Regimar Garcia dos

; Baio, Fábio Henrique Rojo

; Silva Júnior, Carlos Antonio da

; Teodoro, Paulo Eduardo

; Teodoro, Larissa Pereira Ribeiro

Revista Ceres

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Jan 2023, Volume 70 Nº 1 Páginas 106 - 113

Resumo: En | Texto: En | PDF: En

ABSTRACT High-throughput phenotyping (HTP) using vegetation indices (VIs) is an important data source for managing plant breeding programs and can be a promising tool in indirect selection. This study hypothesized that VIs are correlated with agronomic traits in corn, and therefore, HTP can be an auxiliary tool for selecting superior genotypes. The objectives were: i) to analyze the association between agronomic traits and VIs, and ii) to identify superior corn hybrids for the evaluated traits using multivariate techniques. Ten corn hybrids (AGRI 330, AGRI 340, FS575PWU, KTZ006VP3, MG545AW, MG580PW, MG711PW, MZ1780, MZ1952, and TROPI 102) were evaluated for plant height (PH), stem diameter (SD), and grain yield (GY). The VIs studied were NDVI, NDRE, EVI, GNDVI, SAVI, and MSAVI. Pearson’s correlation network was constructed to analyze the relationship between the variables, and a canonical analysis was performed to verify the inter-relationship between the variables and hybrids. The VIs evaluated are strongly positively correlated with each other and with PH. The most productive hybrids are MG545AW, FS575PWU and KTZ006VP3. Hybrid MZ1952 has higher correlations with VIs and PH. The findings reveal that VIs can be excellent auxiliary variables for selecting agronomically superior genotypes, being a promising alternative to increase corn breeding efficiency. Highthroughput High throughput (HTP (VIs selection therefore genotypes i ii techniques 330 340 FSPWU FS PWU KTZ006VP3 KTZVP KTZ VP MG545AW MGAW MG AW MG580PW MGPW PW MG711PW MZ1780 MZ 102 PH, PH , (PH) SD, SD (SD) GY. GY . (GY) NDVI NDRE EVI GNDVI SAVI MSAVI Pearsons Pearson s interrelationship inter MZ195 efficiency 33 34 KTZ006VP MZ178 10 (PH (SD (GY MZ19 3 MZ17 1 MZ1

https://doi.org/10.1590/0034-737x202370010012

13.

Vascular complications in 305 severely ill patients with COVID-19: a cohort study 30 COVID19 COVID 19 COVID-19 3 COVID1 1 COVID-1 COVID-
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Correia, Rebeca Mangabeira

; Santos, Brena Costa

; Carvalho, Ana Alyra Garcia

; Areias, Libnah Leal

; Kuramoto, Danielle Akemi Bergara

; Pereda, Mariana Raffo

; Aidar, Ana Laura e Silva

; Clezar, Caroline Nicacio Bessa

; Reicher, Marcello Erich

; Amorim, Jorge Eduardo de

; Flumignan, Ronald Luiz Gomes

; Nakano, Luis Carlos Uta

Sao Paulo Medical Journal

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2023, Volume 141 Nº 5 elocation e2022171

Resumo: En | Texto: En | PDF: En

ABSTRACT BACKGROUND: Although an association has been made between coronavirus disease 2019 (COVID-19) and microvascular disease, data on vascular complications (other than venous thromboembolism) are sparse. OBJECTIVE: To investigate the vascular complications in severely ill patients hospitalized with COVID-19 and their association with all-cause mortality. DESIGN AND SETTING: This cohort study was conducted at the Universidade Federal de São Paulo, Brazil. METHODS: All 305 consecutive patients diagnosed with COVID-19 and hospitalized in the intensive care unit (ICU) of a tertiary university hospital from April 2 to July 17, 2021, were included and followed up for 30 days. RESULTS: Of these, 193 (63.3%) were male, and the mean age was 59.9 years (standard deviation = 14.34). The mortality rate was 56.3% (172 patients), and 72 (23.6%) patients developed at least one vascular complication during the follow-up period. Vascular complications were more prevalent in the non-survivors (28.5%) than in the survivors (17.3%) group and included disseminated intravascular coagulation (DIC, 10.8%), deep vein thrombosis (8.2%), acrocyanosis (7.5%), and necrosis of the extremities (2%). DIC (adjusted odds ratio (aOR) 2.30, 95% confidence interval (CI) 1.01–5.24, P = 0.046) and acrocyanosis (aOR 5.21, 95% CI 1.48–18.27, P = 0.009) were significantly more prevalent in the non-survivors than in the survivors group. CONCLUSION: Vascular complications in critically ill COVID-19 patients are common (23.6%) and can be closely related to the mortality rate (56.3%) until 30 days after ICU admission. Macrovascular complications have direct implications for mortality, which is the main outcome of the management of COVID-19. REGISTRATION: RBR-4qjzh7 (https://ensaiosclinicos.gov.br/rg/RBR-4qjzh7). BACKGROUND 201 COVID19 COVID 19 (COVID-19 other thromboembolism sparse OBJECTIVE COVID-1 allcause all cause SETTING Paulo Brazil METHODS (ICU 17 2021 3 RESULTS these 63.3% 633 63 (63.3% male 599 59 9 59. standard 14.34. 1434 14.34 . 14 34 14.34) 563 56 56.3 172 (17 patients, , patients) 7 23.6% 236 23 6 (23.6% followup follow period nonsurvivors non 28.5% 285 28 5 (28.5% 17.3% 173 (17.3% DIC, (DIC 10.8%, 108 10.8% 10 8 10.8%) 8.2%, 82 8.2% (8.2%) 7.5%, 75 7.5% (7.5%) 2%. 2% (2%) adjusted aOR 230 2.30 95 (CI 101524 1 01 24 1.01–5.24 0.046 0046 0 046 521 21 5.21 1481827 48 18 27 1.48–18.27 0.009 0009 009 CONCLUSION (56.3% admission COVID19. 19. REGISTRATION RBR4qjzh7 RBRqjzh RBR 4qjzh7 qjzh RBR-4qjzh https//ensaiosclinicos.gov.br/rg/RBR4qjzh7. httpsensaiosclinicosgovbrrgRBR4qjzh7 httpsensaiosclinicosgovbrrgRBRqjzh https //ensaiosclinicos.gov.br/rg/RBR ensaiosclinicos gov br rg (https://ensaiosclinicos.gov.br/rg/RBR-4qjzh7) 20 COVID1 (COVID-1 COVID- 202 63.3 (63.3 143 14.3 56. (1 23.6 (23.6 28.5 (28.5 17.3 (17.3 10.8 8.2 (8.2% 7.5 (7.5% (2% 2.3 10152 1.01–5.2 0.04 004 04 52 5.2 148182 4 1.48–18.2 0.00 000 00 (56.3 RBR4qjzh 4qjzh https//ensaiosclinicos.gov.br/rg/RBR4qjzh7 httpsensaiosclinicosgovbrrgRBR httpsensaiosclinicosgovbrrgRBR4qjzh ensaiosclinicosgovbrrgRBR (https://ensaiosclinicos.gov.br/rg/RBR-4qjzh7 (COVID- 63. (63. 14. ( 23. (23. 28. (28. 17. (17. 10. 8. (8.2 7. (7.5 (2 2. 1015 1.01–5. 0.0 5. 14818 1.48–18. (56. https//ensaiosclinicos.gov.br/rg/RBR4qjzh (https://ensaiosclinicos.gov.br/rg/RBR-4qjzh (COVID (63 (23 (28 (8. (7. 101 1.01–5 0. 1481 1.48–18 (56 (6 (8 (7 1.01– 148 1.48–1 (5 1.01 1.48– 1.0 1.48 1. 1.4

https://doi.org/10.1590/1516-3180.2022.0171.r2.17102022

14.

Post nirmatrelvir/ritonavir erythema multiforme in a patient with coronavirus disease infection nirmatrelvirritonavir nirmatrelvir ritonavir
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Tavares-Júnior, José Wagner Leonel

; Pompeu Filho, José Carlos Jucá

; Galvão, Luiz Eduardo Garcia

Revista da Sociedade Brasileira de Medicina Tropical

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2023, Volume 56 elocation e0008-2023

Resumo: En | Texto: En | PDF: En

ABSTRACT Erythema multiforme (EM), an immune-mediated skin condition, can occur after infection or following the use of medications. In this study, we describe a patient who developed EM after nirmatrelvir/ritonavir administration. An 81-year-old woman presented with fever and dyspnea. Laboratory investigations showed positive coronavirus disease (COVID-19) based on polymerase chain reaction assay, and she received a 5-day regimen of nirmatrelvir/ritonavir. We observed development of EM after this treatment and initiated prednisone (1 mg/kg) therapy, which led to rapid improvement. Our study is the first to report EM in a patient with COVID-19, who received nirmatrelvir/ritonavir and showed a favorable response. EM, , (EM) immunemediated immune mediated condition medications nirmatrelvirritonavir nirmatrelvir ritonavir administration 81yearold yearold 81 year old dyspnea COVID19 COVID 19 (COVID-19 assay 5day day 5 1 ( mg/kg mgkg mg kg therapy improvement COVID19, 19, COVID-19 response (EM 8 COVID1 (COVID-1 COVID-1 (COVID- COVID- (COVID

https://doi.org/10.1590/0037-8682-0008-2023

15.

Deeper exploration of inflammatory cell populations in milk to monitor udder health in dairy cows
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Souza, Carolina Menezes Suassuna de

; Blagitz, Maiara Garcia

; Souza, Fernando Nogueira

; Batista, Camila Freitas

; Lima, Daniel Magalhães

; Alves, Alexandre José

; Heinemann, Marcos Bryan

; Sanchez, Eduardo Milton Ramos

; Torres, Hugo Frias

; Fernandes, Artur Cezar de Carvalho

; Libera, Alice Maria Melville Paiva Della

Scientia Agricola

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2023, Volume 80 elocation e20220086

Resumo: En | Texto: En | PDF: En

ABSTRACT The present study explored the predictive values of milk leukocyte differentials (MLD) as a basis for improving the diagnosis of intramammary infections (IMIs) and subclinical mastitis. Quarter milk samples were collected for bacteriological analysis, quarter somatic cell count (qSCC), and MLD. The MLD were assessed using the cytospin technique, direct microscopic smears, and flow cytometry. The predictive values of each single leukocyte population and useful potential indices that could better reflect immune complexity were also calculated. Changes in the percentage of any leukocyte alone failed to substantially improve the predictive value of qSCC in diagnosing IMIs. Although certain parameters increased the area under the receiver operating characteristic curve (ROC curve) as a result of increased specificity values, a slight reduction in sensitivity was observed. The so-called CD8 complex was a unique parameter which improved both the sensitivity (78.79 %) and the specificity (80.77 %) in IMI diagnosis, resulting in the highest area under the ROC curve (0.87). To diagnose subclinical mastitis, the percentage of macrophages and the sum of the percentage PMNLs and T CD8+ cells divided by the percentage of macrophages showed the highest predictive values (sensitivity = 79.63, specificity = 73.68, and area under the ROC curve = 0.83) in the differentiation of the inflammatory condition status of cows. In conclusion, this study provides further insights into using T CD8+ lymphocytes in diagnosing bovine IMIs, combined with PMNLs and macrophages. The antidromic trend of macrophages vs. PMNLs and T CD8+ lymphocytes due to the increasing qSCCs was crucial to differentiating quarters under both inflammatory and non-inflammatory conditions. (MLD IMIs (IMIs mastitis analysis qSCC, , (qSCC) technique smears cytometry calculated observed socalled so called CD 78.79 7879 78 79 (78.7 % 80.77 8077 80 77 (80.7 0.87. 087 0.87 . 0 87 (0.87) 7963 63 79.63 7368 73 68 73.68 0.83 083 83 cows conclusion vs noninflammatory non conditions (qSCC 78.7 787 7 (78. 80.7 807 8 (80. 08 0.8 (0.87 796 6 79.6 736 73.6 78. (78 80. (80 0. (0.8 79. 73. (7 (8 (0. ( (0

https://doi.org/10.1590/1678-992x-2022-0086

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