Abstract Objectives: The aim was to estimate the pubertal growth height of children and adolescents living in a high-altitude region of Peru using the Preece-Baines model 1 (1 PB). Methods: A cross-sectional study was conducted in schoolchildren from the department of Puno (Peru) between 3841 and 3874 masl. The age range was between 4 and 17 years. Standing height was evaluated. 1 PB was used to infer the mathematical and biological parameters of stature. Results: Mathematical parameters estimated by the 1 PB model reflected small residual standard error (RSE) values in both sexes (0.25 in boys and 0.27 in girls). In boys, the age at which peak velocity was reached (APHV) was estimated at 13.21 ± 0.33years. While in girls it was 9.96 ± 0.26years (p < 0.05). In general, girls reached APHV (y) 3.25 years earlier than boys. On the other hand, the growth velocity of maximum height [APHV (cm/y)] of boys was higher (6.33 ± 6.06 cm/y) relative to girls (6.06 ± 0.32 cm/y). Estimated final adult height (EFAH) in boys was reached at 166.020 ± 0.99 cm and height at maximum growth velocity (HPHV) was 153.07 ± 0.67 cm, while in girls they were significantly lower (EFAH; 153.74 ± 0.44 cm and HPHV: 139.73 ± 0.84 cm). Conclusions: This study showed that girls living in Puno at a high altitude in Peru reached APHV 3 years earlier than boys and at the same time reflected slower PHV. These results suggest that pubertal growth at high altitudes is slower in both sexes and especially in girls. Thus, modeling physical growth may be an important step in understanding the onset of puberty at different latitudes. Objectives highaltitude PreeceBaines Preece Baines ( PB. . PB) Methods crosssectional cross sectional (Peru 384 387 masl evaluated stature Results RSE (RSE 0.25 025 0 25 (0.2 027 27 0.2 girls) (APHV 1321 13 21 13.2 033years 33years 0.33years 996 9 96 9.9 026years 26years p 0.05. 005 0.05 05 0.05) general y (y 325 3.2 hand cm/y cmy (cm/y) 6.33 633 6 33 (6.3 606 06 6.0 (6.0 032 32 0.3 cm/y. EFAH (EFAH 166020 166 020 166.02 099 99 0.9 HPHV (HPHV 15307 153 07 153.0 067 67 0.6 15374 74 153.7 044 44 0.4 13973 139 73 139.7 084 84 0.8 cm. cm) Conclusions PHV Thus latitudes 38 02 2 (0. 0. 132 13. 9. 00 0.0 3. (cm/y 6.3 63 (6. 60 6. 03 16602 16 166.0 09 1530 15 153. 1537 7 04 1397 139. 08 8 (0 (6 1660 166.

Abstract The provision of services for comprehensive healthcare requires the involvement of various professionals with specific competencies to provide the best possible care to the population. The inclusion of nutritionists at different levels of the healthcare system is crucial to ensure comprehensive care at various stages of life. An unequal distribution of nutritionists across healthcare levels can lead to fragmented care and missed opportunities to address nutrition-related issues. Therefore, a study was conducted with the aim of describing the distribution of nutritionists in healthcare facilities according to the level of care and evaluating compliance with the human resources recommendations established by the technical standard of Nutrition and Dietetics UPSS. A descriptive and cross-sectional study was conducted using the analysis of secondary sources. Human resources data from SUSALUD for the year 2022 were used. The Technical Standard of UPSS of Nutrition and Dietetics was considered to assess compliance with human resources recommendations. Among the main findings, it was identified that 7.93% of first-level healthcare facilities have at least one nutritionist. In the second level of care, 96.35% of healthcare facilities do not comply with the human resources recommendations of the technical standard, and no third-level healthcare facility met this recommendation. The distribution of nutritionists across various levels of care in the Peruvian healthcare system is unequal. It is necessary to improve human resources planning in the Peruvian healthcare system to ensure comprehensive healthcare for the population..

Resumen La prestación de servicios para la atención integral de la salud requiere la participación de diversos profesionales con competencias específicas para brindar la mejor atención posible a la población. La inclusión del nutricionista en los diferentes niveles del sistema de salud es crucial para garantizar una atención integral en las diversas etapas de la vida. Una distribución inequitativa de nutricionistas en los niveles de atención puede conducir a una fragmentación de la atención y la pérdida de oportunidades para abordar los problemas relacionados con la alimentación y nutrición. Por ello, se desarrolló un estudio con el objetivo de describir la distribución de nutricionistas en los establecimientos de salud según el nivel de atención, y evaluar el cumplimiento de las recomendaciones de recursos humanos establecidas por la norma técnica de las UPSS de Nutrición y Dietética. Se desarrolló un estudio descriptivo y transversal, mediante el análisis de fuentes secundarias. Se utilizaron los datos de recursos humanos por IPRESS de SUSALUD, del año 2022. Se consideró la Norma técnica de UPSS de Nutrición y Dietética para evaluar el cumplimiento de las recomendaciones de recursos humanos. Entre los principales resultados, se identificó que el 7.93% de los establecimientos de salud del primer nivel de atención tienen al menos un nutricionista. En el segundo nivel de atención, el 96.35% de los establecimientos de salud no cumplen con las recomendaciones de recursos humanos de la norma técnica, y ningún establecimiento del tercer nivel de atención cumplió esta recomendación. La distribución de nutricionistas en los diversos niveles de atención del sistema de salud peruano es desigual. Es necesario mejorar la planificación de recursos humanos en el sistema de salud peruano para garantizar una atención integral de la salud a la población.

Abstract In this work, we focus on obtaining insights of the performances of some well-known machine learning image classification techniques (k-NN, Support Vector Machine, randomized decision tree and one based on stochastic distances) for PolSAR (Polarimetric Synthetic Aperture Radar) imagery. We test the classifiers methods on a set of actual PolSAR data and provide some conclusions. The aim of this work is to show that suitable adapted standard machine learning methods offer excellent performances vs. computational complexity trade-off for PolSAR image classification. In this work, we evaluate well-known machine learning techniques for PolSAR (Polarimetric Synthetic Aperture Radar) image classification, including K-Nearest Neighbors (KNN), Support Vector Machine (SVM), randomized decision tree, and a method based on the Kullback-Leibler stochastic distance. Our experiments with real PolSAR data show that standard machine learning methods, when adapted appropriately, offer a favourable trade-off between performance and computational complexity. The KNN and SVM perform poorly on these data, likely due to their failure to account for the inherent speckle presence and properties of the studied reliefs. Overall, our findings highlight the potential of the Kullback-Leibler stochastic distance method for PolSAR image classification. wellknown well known kNN, kNN k NN, NN (k-NN distances Polarimetric Radar imagery conclusions vs tradeoff trade off KNearest K Nearest KNN, , (KNN) SVM, (SVM) KullbackLeibler Kullback Leibler appropriately reliefs Overall (KNN (SVM

Resumen: El objetivo de este estudio fue analizar si existe asociación entre la violencia por pareja íntima durante el embarazo y el tiempo para volver a la actividad sexual después del parto en la cohorte BRISA, en São Luis, Maranhão, Brasil, entre 2010 y 2013. Se trata de un estudio longitudinal realizado con 665 mujeres. Se midió la violencia por pareja íntima durante el embarazo a través de un instrumento para medir la violencia contra la mujer creado y validado por la Organización Mundial de la Salud. Se investigó el tiempo para volver a la actividad sexual después del parto a través de un cuestionario estructurado. Se utilizaron modelos de regresión logística para verificar si existe asociación entre la violencia por pareja íntima durante el embarazo y el tiempo para volver a la actividad sexual después del parto. La prevalencia de violencia perpetrada por pareja íntima durante el embarazo fue del 24,06%. La prevalencia de mujeres que volvieron a la actividad sexual dentro de los tres meses posteriores al parto fue del 67,96%. Al analizar la asociación entre la exposición y el resultado, se constató que no hubo asociación en el modelo crudo (OR = 0,88; IC95%: 0,60-1,30), ni en el modelo ajustado (OR = 1,00; IC95%: 0,61-1,63). Los resultados del estudio resaltan la importancia de proporcionar asistencia integral a la salud de la mujer, teniendo en cuenta tanto aspectos físicos como psicológicos, una vez que la violencia afecta significativamente varios aspectos de la vida femenina. Resumen BRISA Luis Maranhão Brasil 201 2013 66 Salud estructurado 2406 24 06 24,06% 6796 67 96 67,96% resultado OR 0,88 088 0 88 IC95% IC95 IC 0,601,30, 060130 0,60 1,30 , 60 1 30 0,60-1,30) 1,00 100 00 0,611,63. 061163 0,61 1,63 . 61 63 0,61-1,63) psicológicos femenina 20 6 240 2 24,06 679 9 67,96 0,8 08 8 IC9 601 0,601,30 06013 060 0,6 130 1,3 3 0,60-1,30 1,0 10 611 0,611,63 06116 061 163 1,6 0,61-1,63 24,0 67,9 0, 0,601,3 0601 13 1, 0,60-1,3 0,611,6 0611 16 0,61-1,6 24, 67, 0,601, 0,60-1, 0,611, 0,61-1, 0,601 0,60-1 0,611 0,61-1 0,60- 0,61-

Abstract: This study aimed to analyze whether there is an association between intimate partner violence during pregnancy and time to return to sexual activity after childbirth in the BRISA cohort in São Luís, Maranhão State, Brazil, between 2010 and 2013. This is a longitudinal study conducted with 665 women. Intimate partner violence during pregnancy was measured using an instrument created and validated by the World Health Organization to measure violence against women. Time to return to sexual activity after childbirth was investigated using a structured questionnaire. Logistic regression models were used to analyze whether there is an association between intimate partner violence during pregnancy and time to return to sexual activity after childbirth. The prevalence of violence by an intimate partner during pregnancy was 24.06%. The prevalence of women who returned to sexual activity within 3 months after childbirth was 67.96%. When analyzing the association between exposure and outcome, no association was found in the crude model (OR = 0.88; 95%CI: 0.60-1.30), nor in the adjusted model (OR = 1.00; 95%CI: 0.61-1.63). The study results highlight the importance of providing comprehensive care to women, considering both physical and psychological aspects, since violence has a significant impact on several aspects of women’s lives. Abstract Luís State Brazil 201 2013 66 questionnaire 2406 24 06 24.06% 6796 67 96 67.96% outcome OR 0.88 088 0 88 95%CI 95CI CI 95 0.601.30, 060130 0.60 1.30 , 60 1 30 0.60-1.30) 1.00 100 00 0.611.63. 061163 0.61 1.63 . 61 63 0.61-1.63) womens s lives 20 6 240 2 24.06 679 9 67.96 0.8 08 8 601 0.601.30 06013 060 0.6 130 1.3 0.60-1.30 1.0 10 611 0.611.63 06116 061 163 1.6 0.61-1.63 24.0 67.9 0. 0.601.3 0601 13 1. 0.60-1.3 0.611.6 0611 16 0.61-1.6 24. 67. 0.601. 0.60-1. 0.611. 0.61-1. 0.601 0.60-1 0.611 0.61-1 0.60- 0.61-

Resumo: O objetivo deste estudo foi analisar se existe associação entre violência por parceiro íntimo na gestação e o tempo de retorno das atividades sexuais após o parto na coorte BRISA, em São Luís, Maranhão, Brasil, entre os anos de 2010 e 2013. Trata-se de estudo longitudinal conduzido com 665 mulheres. A violência por parceiro íntimo na gestação foi medida por meio de instrumento criado e validado pela Organização Mundial da Saúde para medir violência contra a mulher. O tempo de retorno das atividades sexuais após o parto foi investigado por meio de questionário estruturado. Modelos de regressão logística foram utilizados para verificar se existe associação entre violência por parceiro íntimo na gestação e tempo de retorno das atividades sexuais após o parto. A prevalência de violência perpetrada pelo parceiro íntimo na gestação foi de 24,06%. A prevalência de mulheres que retornaram às atividades sexuais em até três meses após o parto foi de 67,96%. Ao analisar a associação entre exposição e desfecho, observou-se que não houve associação no modelo bruto (OR = 0,88; IC95%: 0,60-1,30), nem no modelo ajustado (OR = 1,00; IC95%: 0,61-1,63). Os resultados do estudo evidenciam a importância de prestar assistência integral à saúde da mulher, considerando tanto aspectos físicos quanto psicológicos, uma vez que a violência tem impacto significativo em diversas áreas da vida feminina. Resumo BRISA Luís Maranhão Brasil 201 2013 Tratase Trata 66 mulher estruturado 2406 24 06 24,06% 6796 67 96 67,96% desfecho observouse observou OR 0,88 088 0 88 IC95% IC95 IC 0,601,30, 060130 0,60 1,30 , 60 1 30 0,60-1,30) 1,00 100 00 0,611,63. 061163 0,61 1,63 . 61 63 0,61-1,63) psicológicos feminina 20 6 240 2 24,06 679 9 67,96 0,8 08 8 IC9 601 0,601,30 06013 060 0,6 130 1,3 3 0,60-1,30 1,0 10 611 0,611,63 06116 061 163 1,6 0,61-1,63 24,0 67,9 0, 0,601,3 0601 13 1, 0,60-1,3 0,611,6 0611 16 0,61-1,6 24, 67, 0,601, 0,60-1, 0,611, 0,61-1, 0,601 0,60-1 0,611 0,61-1 0,60- 0,61-

Abstract Neospora caninum is a major cause of reproductive loss in cattle worldwide as it leads to abortion and animal repositioning. Although Toxoplasma gondii does not cause a reproductive problem in cattle, consuming raw or uncooked beef poses the risk of transmission. This study aimed to evaluate the occurrence of anti-N. caninum and anti-T. gondii antibodies in dairy cattle in the West and Northwest regions of São Paulo State, Brazil. A total of 653 serum samples from dairy cows were analyzed using an indirect immunofluorescence assay (IFA). Epidemiological data from the farms were associated with the serological results of the animals by logistic regression based on the presence of antibodies. The frequencies of the antibodies against N. caninum and T. gondii were 41.6% (272/653) and 11.5% (75/653), respectively. A statistically significant association was observed between: the serum anti-N. caninum antibodies and breed, history of food supplementation for calves, introduction of outside animals that later presented reproductive problems, and history of reproductive problems by the trimester of gestation. The present study highlights the importance of neosporosis in dairy cattle in the study regions and that the inclusion of this parasite in the investigation of animals with reproductive disorders is important. repositioning transmission antiN. antiN anti N anti-N antiT. antiT T anti-T State Brazil 65 IFA. IFA . (IFA) 416 41 6 41.6 272/653 272653 272 (272/653 115 11 5 11.5 75/653, 75653 75/653 , 75 (75/653) respectively between breed calves gestation important (IFA 4 41. 272/65 27265 27 (272/65 1 11. 7565 75/65 7 (75/653 272/6 2726 2 (272/6 756 75/6 (75/65 272/ (272/ 75/ (75/6 (272 (75/ (27 (75 (2 (7 (

Resumo Neospora caninum é uma das principais causas de perda reprodutiva em bovinos em todo o mundo, pois leva ao aborto e ao reposicionamento animal. Embora o Toxoplasma gondii não cause problemas reprodutivos em bovinos, o consumo de carne bovina crua ou não cozida apresenta risco de transmissão. Este estudo teve como objetivo avaliar a ocorrência de anticorpos anti-N. caninum e anti-T. gondii em bovinos leiteiros nas regiões Oeste e Noroeste do Estado de São Paulo, Brasil. Um total de 653 amostras de soro de bovinos leiteiros, foi analisado utilizando-se o ensaio de imunofluorescência indireta (IFI). Os dados epidemiológicos das propriedades foram associados aos resultados sorológicos dos animais por meio de regressão logística. As frequências dos anticorpos contra N. caninum e T. gondii foram 41,6% (272/653) e 11,5% (75/653), respectivamente. Foi observada associação estatisticamente significativa entre: soropositividade para N. caninum e raça, histórico de suplementação alimentar para bezerros, introdução de animais externos que, posteriormente, apresentaram problemas reprodutivos e histórico de problemas reprodutivos no segundo trimestre de gestação. O presente estudo destaca a importância da neosporose em bovinos leiteiros, nas regiões de estudo, e a inclusão deste parasita na investigação de animais com distúrbios reprodutivos é fundamental. mundo animal transmissão antiN. antiN anti N anti-N antiT. antiT T anti-T Paulo Brasil 65 utilizandose utilizando se IFI. IFI . (IFI) logística 416 41 6 41,6 272/653 272653 272 (272/653 115 11 5 11,5 75/653, 75653 75/653 , 75 (75/653) respectivamente entre raça bezerros que posteriormente gestação fundamental (IFI 4 41, 272/65 27265 27 (272/65 1 11, 7565 75/65 7 (75/653 272/6 2726 2 (272/6 756 75/6 (75/65 272/ (272/ 75/ (75/6 (272 (75/ (27 (75 (2 (7 (

Resumen: El objetivo de este estudio fue analizar si existe asociación entre la violencia por pareja íntima durante el embarazo y el tiempo para volver a la actividad sexual después del parto en la cohorte BRISA, en São Luis, Maranhão, Brasil, entre 2010 y 2013. Se trata de un estudio longitudinal realizado con 665 mujeres. Se midió la violencia por pareja íntima durante el embarazo a través de un instrumento para medir la violencia contra la mujer creado y validado por la Organización Mundial de la Salud. Se investigó el tiempo para volver a la actividad sexual después del parto a través de un cuestionario estructurado. Se utilizaron modelos de regresión logística para verificar si existe asociación entre la violencia por pareja íntima durante el embarazo y el tiempo para volver a la actividad sexual después del parto. La prevalencia de violencia perpetrada por pareja íntima durante el embarazo fue del 24,06%. La prevalencia de mujeres que volvieron a la actividad sexual dentro de los tres meses posteriores al parto fue del 67,96%. Al analizar la asociación entre la exposición y el resultado, se constató que no hubo asociación en el modelo crudo (OR = 0,88; IC95%: 0,60-1,30), ni en el modelo ajustado (OR = 1,00; IC95%: 0,61-1,63). Los resultados del estudio resaltan la importancia de proporcionar asistencia integral a la salud de la mujer, teniendo en cuenta tanto aspectos físicos como psicológicos, una vez que la violencia afecta significativamente varios aspectos de la vida femenina.

Abstract: This study aimed to analyze whether there is an association between intimate partner violence during pregnancy and time to return to sexual activity after childbirth in the BRISA cohort in São Luís, Maranhão State, Brazil, between 2010 and 2013. This is a longitudinal study conducted with 665 women. Intimate partner violence during pregnancy was measured using an instrument created and validated by the World Health Organization to measure violence against women. Time to return to sexual activity after childbirth was investigated using a structured questionnaire. Logistic regression models were used to analyze whether there is an association between intimate partner violence during pregnancy and time to return to sexual activity after childbirth. The prevalence of violence by an intimate partner during pregnancy was 24.06%. The prevalence of women who returned to sexual activity within 3 months after childbirth was 67.96%. When analyzing the association between exposure and outcome, no association was found in the crude model (OR = 0.88; 95%CI: 0.60-1.30), nor in the adjusted model (OR = 1.00; 95%CI: 0.61-1.63). The study results highlight the importance of providing comprehensive care to women, considering both physical and psychological aspects, since violence has a significant impact on several aspects of women’s lives.

Resumo: O objetivo deste estudo foi analisar se existe associação entre violência por parceiro íntimo na gestação e o tempo de retorno das atividades sexuais após o parto na coorte BRISA, em São Luís, Maranhão, Brasil, entre os anos de 2010 e 2013. Trata-se de estudo longitudinal conduzido com 665 mulheres. A violência por parceiro íntimo na gestação foi medida por meio de instrumento criado e validado pela Organização Mundial da Saúde para medir violência contra a mulher. O tempo de retorno das atividades sexuais após o parto foi investigado por meio de questionário estruturado. Modelos de regressão logística foram utilizados para verificar se existe associação entre violência por parceiro íntimo na gestação e tempo de retorno das atividades sexuais após o parto. A prevalência de violência perpetrada pelo parceiro íntimo na gestação foi de 24,06%. A prevalência de mulheres que retornaram às atividades sexuais em até três meses após o parto foi de 67,96%. Ao analisar a associação entre exposição e desfecho, observou-se que não houve associação no modelo bruto (OR = 0,88; IC95%: 0,60-1,30), nem no modelo ajustado (OR = 1,00; IC95%: 0,61-1,63). Os resultados do estudo evidenciam a importância de prestar assistência integral à saúde da mulher, considerando tanto aspectos físicos quanto psicológicos, uma vez que a violência tem impacto significativo em diversas áreas da vida feminina.

ABSTRACT Introduction: The En-bloc Resection of Bladder Tumors (ERBT) is a method that offers more benefits compared to the traditional Transurethral Resection of Bladder Tumor (TURBT) (1, 2). Recent studies have shown that ERBT offers better pathological analysis and oncological outcomes (3-6). Thulium and holmium are the most frequently used lasers for this procedure, with the hybrid laser being a new addition that combines thulium and diode to improve hemostatic properties (5, 7-9). Objective: This report aims to discuss the use of two types of lasers, hybrid and holmium, for ERBT. Material and Methods: Two case studies were conducted. The first case featured a 68-year-old male with two tumors measuring 1.5cm and 2cm. The hybrid laser was used for the procedure. The second case involved a 70-year-old female with a 5cm tumor on the posterior bladder wall, and holmium laser was used with morcellation of the tumor. The quality of histopathological analysis was evaluated. The perioperative data and the entire procedure of the two cases were documented in a step-by-step video. Results: Both lasers demonstrated excellent results without technical difficulties. There was no bleeding, and both patients were discharged with one day of hospitalization. The detrusor muscle was present without artifacts, and the morcellation did not affect the analysis. The first case showed a pT1G3, and the second case showed a pT2 urothelial carcinoma. The hybrid laser exhibited superior hemostatic capacity compared to the holmium laser. Conclusion: ERBT can use hybrid or holmium lasers without affecting histopathological analysis, even with morcellation. Introduction Enbloc En bloc (ERBT TURBT (TURBT 1, 1 (1 2. 2 . 2) 36. 36 3 6 (3-6) 5, 5 (5 79. 79 7 9 7-9) Objective Methods conducted 68yearold yearold 68 year old 15cm cm 2cm 70yearold 70 wall evaluated stepbystep step by video Results difficulties bleeding hospitalization artifacts pT1G3 pTG pT G carcinoma Conclusion ( (3-6 7-9 pT1G (3- 7- (3

ABSTRACT The effect of including whey in the diet of rams in the fattening stage of the company SAIS Pachacutec S.A.C, located in the central mountains of Peru at an altitude of 4119 m was evaluated. In total, 120 five-month-old Corriedale male rams from the «Cabaña» (n=40), «Plantel» (n=40) and «Majada» (n=40) genetic sections were used. Rams from each section was randomly distributed into four treatment groups (n=10 per group): T1 (0%, control); T2 (15%); T3 (25%) and T4 (35% whey). The whey was added to the concentrate (bran feed). The study included 14 days of adaptation to the feed and 90 days of trial. Final weight, weight gain and carcass weight were significantly different between treatments and sections (p<0.05), being greater in T4 and in the Cabaña section (final weight: 48.7 ± 0.6 kg; weight gain: 379.4 g/day; carcass weight: 20.9 ± 1.2 kg). Carcass yield was similar between groups (43.0 ± 0.01%; p>0.05). The results suggest that, with a greater amount of whey, within of the quantities used in the study, better fattening performances of rams are obtained.

RESUMEN Se evaluó el efecto de incluir suero de leche en la dieta de carneros en la etapa de engorde de la empresa SAIS Pachacutec S.A.C, ubicada en la sierra central del Perú a una altitud de 4119 m. Se utilizaron 120 carnerillos machos Corriedale de cinco meses de edad pertenecientes a las secciones de cabaña (n=40), plantel (n=40) y majada (n=40). Cada sección fue dividida aleatoriamente en cuatro grupos (n=10 por grupo) de tratamiento: T1 (0%, testigo); T2 (15%); T3 (25%) y T4 (35% de suero de leche). El suero de leche fue adicionado al concentrado (afrechillo). Se consideraron 14 días de adaptación al alimento y 90 días de ensayo. El peso final, la ganancia de peso y el peso de carcasa fue significativamente diferente entre tratamientos y entre secciones (p<0.05), siendo mayor en T4 y en la sección Cabaña (peso final: 48.7 ± 0.6 kg; ganancia de peso: 379.4 g/día; peso de carcasa: 20.9 ± 1.2 kg). El rendimiento de carcasa fue similar entre grupos (43.0 ± 0.01%; p>0.05). Los resultados sugieren que, con una mayor cantidad de suero de leche, dentro de las cantidades empleadas en el estudio, se obtienen mejores rendimientos de engorde de carnerillos.

Resumen El objetivo fue determinar la DL50 y RC50 e inducir variación morfológica en la variedad de jamaica UAN-8 mediante rayos gamma para seleccionar plantas mutantes de interés agronómico en la generación M2. Las dosis de radiación utilizadas fueron: 0, 100, 200, 300, 400, 500, 600, 700, 800, 900 y 1 000 Gy. Los experimentos se realizaron bajo condiciones de invernadero y campo en Río Grande, Villa de Tututepec, Oaxaca, durante el año 2018. Se utilizó el diseño experimental bloques al azar con cuatro repeticiones. En M1, se evaluó la emergencia de plántula, supervivencia, altura y porcentaje de plantas con semilla. En M2, se registró la variación morfológica y se seleccionaron plantas mutantes. Los datos de supervivencia y altura de planta se analizaron mediante una regresión no lineal para determinar la dosis letal y reductiva media (DL50 y RC50). La DL50 y RC50 se encontró a 395.48 y 453.2 Gy, respectivamente. Las semillas M2 de dicha variedad produjeron plantas con variabilidad morfológica en dosis desde 100 hasta 300 Gy. De estas plantas fue posible identificar seis genotipos mutantes promisorios. El genotipo identificado como S7 L13 presentó características morfológicas deseables como mayor número de cálices rojo por planta y pubescencia ausente o muy débil, comparado con las plantas del genotipo parental.

Abstract The objective was to determine the LD50 and RC50 and induce morphological variation in the roselle variety UAN-8 by gamma rays to select mutant plants of agronomic interest in the M2 generation. The radiation doses used were: 0, 100, 200, 300, 400, 500, 600, 700, 800, 900 and 1 000 Gy. The experiments were conducted under greenhouse and field conditions in Río Grande, Villa de Tututepec, Oaxaca, in 2018. The experimental design used was randomized blocks with four repetitions. In M1, seedling emergence, survival, height and percentage of plants were evaluated. In M2, morphological variation was recorded, and mutant plants were selected. Plant survival and height data were analyzed using nonlinear regression to determine the median lethal and reductive doses (LD50 and RC50). The LD50 and RC50 were found at 395.48 and 453.2 Gy, respectively. The M2 seeds of this variety produced plants with morphological variability in doses from 100 to 300 Gy. From these plants, it was possible to identify six promising mutant genotypes. The genotype identified as S7 L13 presented desirable morphological characteristics such as a higher number of red calyces per plant and absent or very weak pubescence, compared to the plants of the parental genotype.

Abstract Objectives: The objective of the study was to verify whether (FFM), maturity status (MS) and chronological age (CA) are determinants of physical fitness performance, and to analyze FFM and physical performance aligned by CA and MS in children and adolescents. Methods: A descriptive correlational study was carried out in 863 schoolchildren. Weight, height, and waist circumference (WC) were evaluated. Body mass index (BMI), FFM, fat mass (FM), MS (Age at peak height velocity, APHV) were calculated. The physical tests of velocity 20 m, agility 5 m × 10rep, and horizontal jump (HJ) were evaluated. Results: The APHV was estimated in boys at 14.0 ± 0.36APHV and in girls at 11.96 ± 0.49APHV. The relationships between CA and APHV with FFM was r = 0.80 in boys and r = 0.44 to 0.45 in girls. The relationships between FFM and physical tests in boys were [HJ (r = 0.70), agility 5m × 10rep (r = -0.68), velocity (r = -0.61)] and in girls [HJ (r = 0.42), agility 5m × 10rep (r = -0.52), velocity (r = -0.20)]. The differences in FFM and physical fitness tests were more pronounced when aligned by APHV than by CA. Conclusion: It was verified that both FFM, CA, and APHV are determinants of physical fitness performance. In addition, the APHV should be introduced in physical education as a means of ranking physical performance among schoolchildren. Objectives , (FFM) (MS (CA adolescents Methods 86 schoolchildren Weight WC (WC evaluated BMI, BMI (BMI) FM, FM (FM) Age calculated 2 rep HJ (HJ Results 140 14 0 14. 036APHV 36APHV 1196 11 96 11.9 049APHV 49APHV 0.49APHV 080 80 0.8 044 44 0.4 045 45 0.70, 070 0.70 70 0.70) 0.68, 068 0.68 68 -0.68) 0.61 061 61 -0.61) 0.42, 042 0.42 42 0.42) 0.52, 052 0.52 52 -0.52) 0.20. 020 0.20 . -0.20)] Conclusion addition (FFM 8 (BMI (FM 1 119 9 11. 08 0. 04 4 07 0.7 7 06 0.6 6 -0.68 -0.61 05 0.5 -0.52 02 0.2 -0.20) -0.6 -0.5 -0.20 -0. -0.2 -0 -

ABSTRACT Objective Published studies have shown associations between anti-ribosomal P (anti-P) antibody and systemic lupus erythematosus with hepatic manifestations. This has been reported also in autoimmune hepatitis. However, the consistency of the latter association remains controversial. This study aimed to evaluate the frequency of anti-P antibodies in autoimmune hepatitis using two different immunoassays. Methods One-hundred and seventy-seven patients with autoimmune hepatitis were screened, and 142 were analyzed for anti-P antibody positivity. The samples were first analyzed using two different immunoassays: enzyme-linked immunosorbent assay (ELISA) and chemiluminescence and then compared with a group of 60 patients with systemic lupus erythematous. The positive samples were subjected to western blot analysis. Results Anti-P was found in 5/142 autoimmune hepatitis cases (3.5%) by chemiluminescence and in none by ELISA. Among the five chemiluminescence-positive autoimmune hepatitis samples, on anti-P western blot analysis one was negative, two were weakly positive, and two were positive. In contrast, anti-P was detected in 10/60 patients with systemic lupus erythematosus (16.7%) and presented higher chemiluminescence units than the autoimmune hepatitis samples. Conclusion A low frequency of anti-P antibodies was observed in autoimmune hepatitis, suggesting that this test is not useful for the diagnosis or management of this disease. antiribosomal anti ribosomal antiP (anti-P manifestations However controversial immunoassays Onehundred One hundred seventyseven seventy seven screened 14 positivity enzymelinked enzyme linked ELISA (ELISA 6 erythematous AntiP Anti 5142 5 5/14 3.5% 35 3 (3.5% chemiluminescencepositive negative contrast 1060 10 10/6 16.7% 167 16 7 (16.7% disease 1 514 5/1 3.5 (3.5 106 10/ 16.7 (16.7 51 5/ 3. (3. 16. (16. (3 (16 ( (1

Resumen Introducción: El tromboembolismo pulmonar es una complicación reportada en la población adulta con COVID-19; sin embargo, en la población pediátrica, su descripción es limitada. Caso clínico: Se reporta el caso de un varón de 15 años con antecedente de obesidad y síndrome de Down que fue hospitalizado por neumonía COVID-19 severa. En el séptimo día de hospitalización presentó dolor torácico, hemoptisis, dificultad respiratoria y elevación del dímero D. En la angiotomografía pulmonar se encontró un extenso trombo en la arteria lobar inferior derecha. Recibió tratamiento con enoxaparina y rivaroxabán evolucionando favorablemente. La resolución al mes de tratamiento fue existosa, ya que el control tomográfico no evidenció más el trombo. Conclusiones: El tromboembolismo pulmonar es una complicación poco reportada en niños con neumonía COVID-19. El diagnóstico oportuno y tratamiento anticoagulante es importante para evitar complicaciones mortales.

Abstract Background: Pulmonary embolism (PE) is a complication reported in the adult population with coronavirus disease 2019 (COVID-19); however, its documentation in the pediatric population is limiteda. Case report: We report the case of a 15-year-old male with obesity and Down syndrome who was admitted for severe COVID-19 pneumonia. On day 7 of admission, he presented with chest pain, hemoptysis, respiratory distress, and marked elevation of D-dimer. Pulmonary CT angiography found an extensive thrombus in the right lower lobar artery. He received treatment with enoxaparin and rivaroxaban and had a favorable clinical outcome. In the tomographic control 1 month after treatment, thrombus was not evidenced and was successfully resolved. Conclusions: There are few reports of PE in children with COVID-19. Prompt diagnosis and early anticoagulant treatment are important to avoid life-threatening complications.

Abstract Objective To describe the clinical results of patients admitted and managed as cases of placenta accreta spectrum (PAS) at a Central American public hospital and the influence of the prenatal diagnosis on the condition. Materials and Methods A retrospective analysis of PAS patients treated at Hospital Bertha Calderón Roque, in Managua, Nicaragua, between June 2017 and September 2021. The diagnostic criteria used were those of the International Federation of Gynecology and Obstetrics (Fédération Internationale de Gynécologie et d'Obstétrique, FIGO, in French). The population was divided into patients with a prenatal ultrasonographic diagnosis of PAS (group 1) and those whose the diagnosis of PAS was established at the time of the caesarean section (group 2). Results During the search, we found 103 cases with a histological and/or clinical diagnosis of PAS; groups 1 and 2 were composed of 51 and 52 patients respectively. Regarding the clinical results of both groups, the patients in group 1 presented a lower frequency of transfusions (56.9% versus 96.1% in group 2), use of a lower number of red blood cell units (RBCUs) among those undergoing transfusions (median: 1; interquartile range: [IQR]: 0–4 versus median: 3; [IQR]: 2–4] in group 2), and lower frequency of 4 or more RBCU transfusions (29.4% versus 46.1% in group 2). Group 1 also exhibited a non-significant trend toward a lower volume of blood loss (1,000 mL [IQR]: 750–2,000 mL versus 1,500 mL [IQR]: 1,200–1,800 mL in group 2), and lower requirement of pelvic packing (1.9% versus 7.7% in group 2). Conclusion Establishing a prenatal diagnosis of PAS is related to a lower frequency of transfusions. We observed a high frequency of prenatal diagnostic failures of PAS. It is a priority to improve prenatal detection of this disease. (PAS condition Roque Managua Nicaragua 201 2021 Fédération dObstétrique, dObstétrique d Obstétrique, Obstétrique d'Obstétrique FIGO French. French . French) 2. 2) search 10 andor 5 respectively 56.9% 569 56 9 (56.9 961 96 96.1 2, , RBCUs (RBCUs median (median range IQR [IQR] 04 0 0– 3 2–4 24 29.4% 294 29 (29.4 461 46 46.1 nonsignificant non significant 1,000 1000 000 (1,00 7502000 750 750–2,00 1500 500 1,50 12001800 200 800 1,200–1,80 1.9% 19 (1.9 77 7 7.7 disease 20 202 56.9 (56. 96. [IQR 2– 29.4 (29. 46. 1,00 100 00 (1,0 750200 75 750–2,0 150 50 1,5 1200180 80 1,200–1,8 1.9 (1. 7. 56. (56 29. (29 1,0 (1, 75020 750–2, 15 1, 120018 8 1,200–1, 1. (1 (5 (2 7502 750–2 12001 1,200–1 ( 750– 1200 1,200– 120 1,200 12 1,20 1,2

Resumo Este artigo examina a difusão de um modelo recente de governança urbana neoliberal que gerenciaria processos de urbanização neoliberal nas cidades de Lima e Callao, considerando o contexto de preparação para sediar os XVIII Jogos Pan-Americanos de Lima 2019. O artigo procura mostrar como megaeventos são utilizados como instrumentos de produção espacial, por meio de coalizões de líderes carismáticos do setor privado e de interesses imobiliários, com a intenção de transformar a cidade através da mobilização do patriotismo e do consenso. Argumenta-se que o Estado promove a urbanização neoliberal através de Parcerias Público-Privadas (PPPs).

Abstract This article examines the diffusion of a recent model of neoliberal urban governance that would manage neoliberal urbanization processes in the cities of Lima and Callao, considering the context of preparation to host the XVIII Pan American Games in Lima, in 2019. The article aims to show how mega events are used as spatial production instruments, through coalitions of charismatic private sector leaders and real estate interests, with the intention of transforming the city through the mobilization of patriotism and consensus. It is argued that the state promotes neoliberal urbanization through Public-Private Partnerships (PPPs).

Resumo Fundamento A esquistossomose é uma doença tropical negligenciada que pode levar a complicações cardiovasculares. No entanto, o envolvimento cardiovascular na esquistossomose ainda precisa ser totalmente elucidado, devido ao número limitado de casos e ausência de evidência confiável, uma vez que a doença ocorre tipicamente em locais sem infraestrutura adequada para uma coleta de dados robusta. Objetivo Esta revisão sistemática teve como objetivo avaliar as implicações cardiovasculares da esquistossomose, incluindo no diagnóstico e tratamento, e propor um algoritmo para rastrear as manifestações cardiovasculares. Métodos Foi realizada uma revisão sistemática nos bancos de dados MEDLINE/PubMed e LILACS, com busca por artigos sobre o comprometimento cardiovascular na esquistossomose. Resultados Trinta e três artigos foram considerados para esta revisão: seis artigos de revisão, uma revisão sistemática, um ensaio clínico, 14 estudos observacionais, sete relatos de casos, e quatro séries de casos. O comprometimento cardiovascular inclui um amplo espectro de condições clínicas, tais como isquemia do miocárdio, disfunção ventricular, miocardite, hipertensão arterial pulmonar, e pericardite. Conclusões As complicações cardíacas da esquistossomose podem causar incapacidade em longo prazo e morte. O monitoramento clínico, exame físico, eletrocardiograma precoce, e ecocardiograma devem ser considerados como medidas chave para detectar o envolvimento cardiovascular. Dada a ausência de um tratamento eficaz das complicações, são necessários saneamento e educação nas áreas endêmicas para a eliminação desse problema de saúde mundial.

Abstract Background Schistosomiasis is a Neglected Tropical Disease which may lead to cardiovascular (CV) complications. However, the CV involvement in schistosomiasis has yet to be fully elucidated due to the limited number of cases and lack of reliable evidence, as schistosomiasis typically occurs in locations without adequate infrastructure for robust data collection. Objective This systematic review aims to assess cardiovascular implications of schistosomiasis, including in the diagnosis and treatment, and propose an algorithm for screening of CV manifestations. Methods A systematic review was performed in the MEDLINE/PubMed and LILACS databases of articles on the CV involvement in schistosomiasis. Results Thirty-three records were considered for this review: six review articles, one systematic review, one clinical trial, 14 observational studies, seven case reports, and four cases series. CV involvement includes a wide spectrum of clinical conditions, such as myocardial ischemia, ventricular dysfunction, myocarditis, pulmonary arterial hypertension, and pericarditis. Conclusions Cardiac complications of schistosomiasis may cause long-term disability and death. Clinical monitoring, physical examination, early electrocardiogram, and echocardiogram should be considered as key measures to detect CV involvement. Due to the lack of effective treatment of complications, sanitation and education in endemic areas are necessary for the elimination of this global health problem.