No Brasil, o controle realizado contra as defensoras de direitos humanos é fundado a partir dos princípios de uma sociedade patriarcal, o qual fundamenta-se num sistema de distribuição desigual de poder, utilizando como base fundamentos biológicos acerca dos sexos para diferenciação social de gênero. A partir deste fenômeno, revela-se uma série de práticas e políticas que limitam a atuação dessas ativistas e comprometem a capacidade de lutar por causas sociais e denunciar violações. Um dos pontos discutidos é que as manifestações e ações propostas por elas, ainda que pacíficas, enfrentam ações repressivas pelo Estado e a falta de proteção contra violência de terceiros, que as tornam alvos de ataques. O controle estrutural é, portanto, um mecanismo que enfraquece a luta por justiça e igualdade. Isso demonstra a importância de desafiar e desconstruir os estigmas associados às identidades de gênero no contexto das lutas pelos direitos humanos e na promoção de uma sociedade mais equitativa e inclusiva. Utiliza-se uma metodologia qualitativa a partir de uma pesquisa bibliográfica e uma base de dados oriunda de entrevistas realizadas com treze ativistas. Objetiva-se compreender a relação entre o controle estrutural e a legitimação implícita da utilização de distintos modos para impedir que mulheres ativistas exerçam seus direitos de livre manifestação e de expressão. Analisamos, por fim, se os direitos fundamentais das ativistas contrastam com o cenário exposto pela investigação empírica, por meio da verificação do conjunto de políticas públicas existentes e de sua (in)eficácia.

In Brazil, the control carried out against human rights defenders is based on the principles of a patriarchal society, which is based on a system of unequal distribution of power, using biological foundations regarding sexes as a basis for social gender differentiation. This phenomenon reveals a series of practices and policies that limit the actions of these activists and compromise their ability to fight for social causes and denounce violations. One of the points discussed is that the demonstrations and actions proposed by them, although peaceful, face repressive actions by the State and the lack of protection against violence by third parties, which make them targets of attacks. Structural control is, therefore, a mechanism that weakens the fight for justice and equality. This demonstrates the importance of challenging and deconstructing the stigmas associated with gender identities in the context of the fight for human rights and in the promotion of a more equitable and inclusive society. A qualitative methodology is used based on bibliographic research and a database of interviews conducted with thirteen activists. The aim is to understand the relationship between structural control and the implicit legitimization of the use of different methods to prevent women activists from exercising their rights to free expression and demonstration. Finally, we analyze whether the fundamental rights of activists contrast with the scenario exposed by empirical research, by verifying the set of existing public policies and their (in)effectiveness.

ABSTRACT: This study evaluated the vaccine-induced serological response after administering four commercial formulations containing Bovine Viral Diarrhea Virus (BVDV) type-1, BVDV-2, and Bovine Herpesvirus type 1 (BoHV-1) to young heifers with circulating maternal antibody titers. The study also determined the anamnestic response to vaccinations after the complete metabolization of maternal antibodies when the calves reached six months. Eighty-seven Holstein heifers were selected and randomly distributed into four experimental groups based on the vaccine administered. The four vaccine-based experimental groups were as follows: vaccine A (n = 22), vaccine B (n = 22), vaccine C (n = 24), and vaccine D (n = 19), given on the 60th, 90th, and 180th day of life, respectively. Virus-neutralization (VN) tests were performed at baseline (day 60) and 30 days after administering the second (day 120) and third doses (day 210). We analyzed the effect of vaccine group (P ≤ 0.001), day of vaccination (P ≤ 0.001), and group versus vaccine day interaction (P ≤ 0.001) for antibody titers produced against BVDV-1, BVDV-2, and BoHV-1 using the PROC MIXED method (Statistical Analysis System -SAS 9.4). Antibody titers against BVDV-1, BVDV-2, and BoHV-1 were similar at baseline and on day 60 of life. The mean antibody titers were constant and persisted against BVDV-1 in heifers immunized with vaccines A and C. Heifers immunized with vaccine A alone had a similar effect against BVDV-2. Regarding BoHV-1, the antibody titers decreased between days 60 and 210 in groups B, C, and D. The antibody titer for heifers in group A also decreased between days 60 and day 120, and an intense increase in titers was observed on day 210. After being immunized with formulations B, C, and D, the frequency of animals with titers above protective levels for BVDV-1, BVDV-2, and BoHV-1 was very low or null. Indicators of anamnestic response were observed in heifers vaccinated with formulation A only. Therefore, it can be concluded that passive immunity negatively interferes with antibody production after vaccination. ABSTRACT vaccineinduced induced BVDV (BVDV type1, type1 1, type-1 BVDV2, BVDV2 2, 2 BVDV-2 BoHV1 BoHV (BoHV-1 months Eightyseven Eighty seven administered vaccinebased follows n 22, 22 , 22) 24, 24 24) 19, 19 19) 60th th 90th life respectively Virusneutralization neutralization VN (VN 3 120 . 210) P 0.001, 0001 0.001 0 001 BVDV1, BVDV1 BoHV- Statistical SAS 9.4. 94 9.4 9 4 9.4) 6 BVDV- BVDV2. 2. BoHV1, 21 null only Therefore type- (BoHV- 12 000 0.00 00 9. (BoHV 0.0 0.

RESUMO: O objetivo desse estudo foi avaliar a resposta sorológica induzida após vacinação com quatro formulações comerciais contendo o BVDV-1, BVDV-2 e BoHV-1 em novilhas jovens com títulos de anticorpos maternos circulantes, assim como analisar uma possível resposta anamnéstica em vacinações, após a completa metabolização dos anticorpos maternais aos seis meses de idade. Foram selecionadas 87 novilhas Holandesas, distribuídas aleatoriamente em quatro grupos experimentais de acordo com as vacinas: vacina A (n = 22), vacina B (n = 22), vacina C (n = 24) e vacina D (n = 19), aplicadas aos dias 60, 90 e 180 de vida. Testes de vírus-neutralização (VN) foram realizados no momento basal (D60) e 30 dias após a aplicação da 2ª dose (D120) e 3ª dose (D210). Observou-se efeito do grupo (P ≤ 0,001), dia da vacinação (P ≤ 0,001), e interação grupo versus dia (P ≤ 0,001) para os títulos de anticorpos produzidos contra o BVDV-1, BVDV-2 e BoHV-1, por meio do comando PROC MIXED (Statistical Analysis System, versão 9,4). Os títulos de anticorpos contra o BVDV-1, BVDV-2 e BoHV-1 eram semelhantes no momento basal aos 60 dias de vida. Os títulos médios de anticorpos foram constantes e persistentes contra o BVDV-1 nas novilhas imunizadas com as vacinas A e C, porém apenas a vacina A teve este mesmo perfil contra o BVDV-2. Em relação ao BoHV-1, os grupos B, C e D apresentaram queda nos títulos de anticorpos do D60 ao D210, enquanto as novilhas do grupo A apresentaram queda do D60 ao D120, com aumento intenso dos títulos no D210. A frequência de animais com títulos acima dos protetores contra o BVDV-1, BVDV-2 e BoHV-1 foram muito baixos ou nulos após as vacinações nos animais imunizados com as formulações B, C e D. Sugere-se que a imunidade passiva interferiu negativamente na indução de anticorpos pelas vacinas, observando-se indicadores de resposta anamnéstica apenas para as novilhas vacinadas com a formulação A. RESUMO BVDV1, BVDV1 BVDV 1, 1 BVDV2 2 BVDV- BoHV1 BoHV BoHV- circulantes idade 8 Holandesas n 22, 22 , 22) 24 19, 19 19) 9 18 vida vírusneutralização vírus neutralização VN (VN (D60 3 ª D120 (D120 D210 . (D210) Observouse Observou se P 0,001, 0001 0,001 0 001 BoHV1, Statistical System 9,4. 94 9,4 4 9,4) 6 BVDV2. 2. D6 Sugerese Sugere observandose observando (D6 D12 (D12 D21 (D210 000 0,00 00 9, (D D1 (D1 D2 (D21 0,0 (D2 0,

Resumen Objetivo Analizar las evidencias disponibles sobre la transición alimentaria de sonda orogástrica a lactancia materna directamente de la mama con prematuros internados en unidades hospitalarias. Métodos Revisión sistemática de la literatura con búsqueda en las bases de datos PubMed/MEDLINE, Web of Science, EMBASE, Scopus, Cochrane CENTRAL, CINAHL, con los siguientes criterios de inclusión: estudios experimentales, sin restricción temporal y en idioma portugués, español e inglés. La evaluación metodológica se realizó por medio de las herramientas Grading of Recommendations Assessment, Development and Evaluation (GRADE) y Revised Cochrane risk-of-bias tool for randomized trials (RoB 2.0) y consistió en dos etapas: calidad metodológica y riesgo de sesgo de los estudios. Resultados Se identificaron 10 artículos, todos ensayos clínicos aleatorizados. Las técnicas utilizadas para la transición de la dieta de prematuros fueron: dedo-jeringa y jeringa, vaso y dedo-jeringa, vaso y mamadera, cuchara y succión no nutritiva, succión no nutritiva, succión no nutritiva y estimulación oral, comportamiento de los prematuros, olor de la leche materna. Conclusión Las técnicas observadas permitieron realizar la transición de la dieta en un período más corto, con reducción del tiempo de internación y mejor aumento de peso y demostraron ser seguras, siempre que el prematuro tenga madurez para realizarlas. No obstante, se desaconseja la mamadera por la presencia de episodios de desaturación, aumento de la frecuencia cardíaca y confusión tetina-pezón. Número de registro da revisão sistemática: CRD42021240725 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=240725) hospitalarias PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE Science EMBASE Scopus CENTRAL CINAHL inclusión experimentales portugués inglés Assessment GRADE (GRADE riskofbias risk bias RoB 2.0 20 2 0 etapas 1 artículos aleatorizados fueron dedojeringa dedo jeringa dedojeringa, oral corto seguras realizarlas obstante desaturación tetinapezón. tetinapezón tetina pezón. pezón tetina-pezón CRD CRD4202124072 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=240725 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID240725 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID https //www.crd.york.ac.uk/prospero/display_record.php RecordID=240725 www crd york ac uk prospero display record php RecordID 240725 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=240725 2. CRD420212407 phpRecordID https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=24072 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID24072 wwwcrdyorkacukprosperodisplayrecordphp RecordID240725 RecordID=24072 24072 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=24072 CRD42021240 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=2407 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID2407 RecordID24072 RecordID=2407 2407 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=2407 CRD4202124 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=240 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID240 RecordID2407 RecordID=240 240 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=240 CRD420212 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=24 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID24 RecordID240 RecordID=24 24 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=24 CRD42021 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=2 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID2 RecordID24 RecordID=2 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=2 CRD4202 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID= RecordID2 RecordID= (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID= CRD420 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID CRD42 CRD4

Abstract Objective To analyze the available evidence on the transition from orogastric tube feeding to breastfeeding directly from the breast with premature infants admitted to hospital units. Methods Systematic literature review with search in the following databases: PubMed/MEDLINE, Web of Science, EMBASE, Scopus, Cochrane CENTRAL, CINAHL, with the inclusion criteria: experimental studies, without temporal restrictions and in Portuguese, Spanish and English. The methodological assessment was carried out using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) and Revised Cochrane risk-of-bias tool for randomized trials (RoB 2.0) tools and consisted of two stages: methodological quality and the risk of bias of the studies. Results 10 papers were identified, all randomized clinical trials. The techniques used in transitioning the premature babies’ diet were: finger tube and syringe, cup and finger tube, cup and bottle, spoon and non-nutritive sucking, non-nutritive sucking, non-nutritive sucking and oral stimulation, behavior of premature babies, and smell of breast milk. Conclusion The demonstrated techniques allowed the transition of the diet in a shorter period, reducing the length of hospital stay, increasing weight gain 1and proved to be safe, as long as the premature baby is mature enough to undergo the procedure. However, bottle feeding was not recommended due to the occurrence of episodes of desaturation, increased heart rate and nipple confusion. Systematic review registration number: CRD42021240725 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=240725) units databases PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE Science EMBASE Scopus CENTRAL CINAHL criteria studies Portuguese English Assessment GRADE (GRADE riskofbias RoB 2.0 20 2 0 stages 1 identified babies syringe nonnutritive non nutritive stimulation milk period stay safe procedure However desaturation confusion number CRD CRD4202124072 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=240725 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID240725 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID https //www.crd.york.ac.uk/prospero/display_record.php RecordID=240725 www crd york ac uk prospero display record php RecordID 240725 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=240725 2. CRD420212407 phpRecordID https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=24072 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID24072 wwwcrdyorkacukprosperodisplayrecordphp RecordID240725 RecordID=24072 24072 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=24072 CRD42021240 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=2407 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID2407 RecordID24072 RecordID=2407 2407 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=2407 CRD4202124 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=240 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID240 RecordID2407 RecordID=240 240 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=240 CRD420212 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=24 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID24 RecordID240 RecordID=24 24 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=24 CRD42021 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=2 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID2 RecordID24 RecordID=2 (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=2 CRD4202 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID= RecordID2 RecordID= (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID= CRD420 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID (https://www.crd.york.ac.uk/prospero/display_record.php?RecordID CRD42 CRD4

Resumo Objetivo Analisar as evidências disponíveis sobre a transição alimentar de sonda orogástrica para aleitamento materno diretamente na mama com prematuros internados em unidades hospitalares. Métodos Revisão sistemática da literatura com busca nas bases de dados PubMed/MEDLINE, Web of Science, EMBASE, Scopus, Cochrane CENTRAL, CINAHL, com os critérios de inclusão: estudos experimentais, sem restrição temporal e nos idiomas português, espanhol e inglês. A avaliação metodológica foi realizada por meio das ferramentas Grading of Recommendations Assessment, Development and Evaluation (GRADE) e Revised Cochrane risk-of-bias tool for randomized trials (RoB 2.0) e consistiu em duas etapas: qualidade metodológica e o risco de viés dos estudos. Resultados Foram identificados 10 artigos, todos ensaios clínicos randomizados. As técnicas utilizadas na transição da dieta dos prematuros encontradas foram: sonda-dedo e seringa, copo e sonda-dedo, copo e mamadeira, colher e sucção não-nutritiva, sucção não-nutritiva, sucção não-nutritiva e estimulação oral, comportamento dos prematuros, cheiro do leite materno. Conclusão As técnicas evidenciadas permitiram a transição da dieta, em um período mais curto, reduzindo o tempo de internação, aumentando o ganho de peso e se mostraram seguras, desde que o prematuro tenha maturidade para ser realizada. Contudo, a mamadeira foi desaconselhada, pela ocorrência de episódios de dessaturação, aumento da frequência cardíaca e confusão de bico. hospitalares PubMedMEDLINE PubMed MEDLINE PubMed/MEDLINE Science EMBASE Scopus CENTRAL CINAHL inclusão experimentais português inglês Assessment GRADE (GRADE riskofbias risk bias RoB 2.0 20 2 0 etapas 1 artigos randomizados foram sondadedo dedo seringa sondadedo, dedo, nãonutritiva, nãonutritiva não nutritiva, nutritiva oral curto internação seguras Contudo desaconselhada dessaturação bico 2.

Abstract Background Knowledge of patients about Rheumatoid Arthritis (RA) is a necessary aspect to better approach self-management support in a patient-centered manner. The research instrument known as the Rheumatoid Arthritis Knowledge Assessment Scale (RAKAS), consisting of 13 items, is simple, reliable and reproducible, and can be applied in both clinical practice and research protocols. Objectives This study aimed to translate and culturally adapt the RAKAS vocabulary into Brazilian Portuguese and to evaluate its concurrent validity. Methods The RAKAS was translated into Brazilian Portuguese and administered to 52 elderly women with RA recruited between May 2021 and May 2022. Concurrent validity was assessed using the Spearman's correlation coefficient between RAKAS and Patient Knowledge Questionnaire (PKQ). Results The participants considered RAKAS-13/BRAZIL easy to understand and did not report any doubts in answering the final version. Concurrent validity of the RAKAS–13/BRAZIL was low compared to the PKQ (ρ = 0.283, p = 0.038). Conclusion The Brazilian Portuguese version of the RAKAS (RAKAS–13/BRASIL) proved to be a questionnaire that was easy and quick to administer to assess patient knowledge about Rheumatoid Arthritis, despite its low correlation with the PKQ in the present study. (RA selfmanagement self management patientcentered centered manner RAKAS, , (RAKAS) 1 items simple reproducible protocols 5 202 2022 Spearmans Spearman s PKQ. . (PKQ) RAKAS13/BRAZIL RAKAS13BRAZIL RAKASBRAZIL 13/BRAZIL BRAZIL ρ 0283 0 283 0.283 0.038. 0038 0.038 038 0.038) RAKAS–13/BRASIL RAKAS13BRASIL RAKASBRASIL BRASIL (RAKAS–13/BRASIL (RAKAS 20 (PKQ RAKAS13 13BRAZIL 028 28 0.28 003 0.03 03 2 RAKAS1 02 0.2 00 0.0 0.

Background: Adhering to a diet adequate in macronutrients is crucial for the secondary prevention of cardiovascular diseases. Objective: To assess the prevalence of adherence to recommendations for the consumption of dietary fatty acids for the prevention and treatment of cardiovascular diseases and to estimate whether the presence of certain cardiovascular risk factors would be associated with adherence. Methods: Cross-sectional study using baseline data from 2,358 participants included in the "Brazilian Cardioprotective Nutritional Program Trial". Dietary intake and cardiovascular risk factors were assessed. Adequate intake of polyunsaturated fatty acids (PUFA) was considered as ≥10% of total daily energy intake; for monounsaturated fatty acids (MUFA), 20%; and for saturated fatty acids (SFA), <7% according to the Brazilian Society of Cardiology. A significance level of 5% was considered in the statistical analysis. Results: No participant adhered to all recommendations simultaneously, and more than half (1,482 [62.9%]) did not adhere to any recommendation. Adherence exclusively to the SFA recommendation was the most prevalent, fulfilled by 659 (28%) participants, followed by adherence exclusively to the PUFA (178 [7.6%]) and MUFA (5 [0.2%]) recommendations. There was no association between the number of comorbidities and adherence to nutritional recommendations (p = 0.269). Participants from the Brazilian Northeast region showed a higher proportion of adherence to SFA consumption recommendations (38.42%) and lower adherence to PUFA intake (3.52%) (p <0.001) compared to other regions. Conclusions: Among the evaluated sample, there was low adherence to nutritional recommendations for dietary fatty acid consumption. Background Objective Methods Crosssectional Cross sectional 2358 2 358 2,35 Trial. Trial . Trial" assessed (PUFA 10 ≥10 MUFA, , (MUFA) 20% 20 SFA, (SFA) 7 <7 Cardiology 5 analysis Results simultaneously 1,482 1482 1 482 (1,48 62.9% 629 62 9 [62.9%] prevalent 65 28% 28 (28% 178 (17 7.6% 76 6 [7.6%] ( 0.2% 02 0 [0.2%] p 0.269. 0269 0.269 269 0.269) 38.42% 3842 38 42 (38.42% 3.52% 352 3 52 (3.52% <0.001 0001 001 regions Conclusions sample 235 35 2,3 ≥1 (MUFA (SFA < 1,48 148 48 (1,4 62.9 [62.9% (28 17 (1 7.6 [7.6% 0.2 [0.2% 026 0.26 26 38.42 384 4 (38.42 3.52 (3.52 <0.00 000 00 23 2, ≥ 1,4 14 (1, 62. [62.9 (2 7. [7.6 0. [0.2 38.4 (38.4 3.5 (3.5 <0.0 1, [62. [7. [0. 38. (38. 3. (3. <0. [62 [7 [0 (38 (3 <0 [6 [

Resumo Fundamento: A adesão à uma alimentação adequada em macronutrientes é fundamental para a prevenção secundária de doenças cardiovasculares. Objetivo: Avaliar a prevalência de adesão às recomendações de consumo de ácidos graxos para prevenção e tratamento de doenças cardiovasculares, e estimar se a presença de determinados fatores de risco cardiovascular estaria associada à adesão. Métodos: Estudo transversal com os dados de linha de base de 2358 participantes do estudo "Brazilian Cardioprotective Nutritional Program Trial". Dados de consumo alimentar, e fatores de risco cardiovascular foram avaliados. Foi considerada, de acordo com a Sociedade Brasileira de Cardiologia, uma ingestão adequada de ácidos graxos poli-insaturados (AGPI) ≥10% do consumo total de energia diária, para ácidos graxos monoinsaturados (AGM), 20% e para ácidos graxos saturados (AGS), <7%. Na análise estatística foi considerando nível de significância de 5%. Resultados: Nenhum participante aderiu a todas as recomendações de forma simultânea e mais da metade (1482 [62,9%]) não aderiu a nenhuma recomendação. A adesão exclusivamente à recomendação de AGS foi a mais prevalente, sendo cumprida por 659 (28%) dos participantes, seguida da adesão exclusivamente à recomendação de AGP (178 [7,6%]) e de AGM (5 [0,2%]). Não houve associação entre o número de comorbidades e a adesão às recomendações nutricionais (p =0,269). Os participantes da região Nordeste do país apresentaram maior proporção de adesão às recomendações para consumo de AGS (38,42%), e menor para ingestão de AGPI (3,52%) (p <0,001) em comparação às demais. Conclusões: Na amostra avaliada, evidenciou-se baixa adesão às recomendações nutricionais para consumo de ácidos graxos. Fundamento cardiovasculares Objetivo Métodos 235 Brazilian Trial. Trial . Trial" alimentar avaliados considerada Cardiologia poliinsaturados poli insaturados (AGPI 10 ≥10 diária AGM, , (AGM) 20 AGS, (AGS) 7 <7% 5 5% Resultados 1482 (148 62,9% 629 62 9 [62,9%] prevalente 65 28% 28 (28% 178 (17 7,6% 76 6 [7,6%] ( 0,2%. 02 0,2% 0 2 [0,2%]) p =0,269. 0269 =0,269 269 =0,269) 38,42%, 3842 38,42% 38 42 (38,42%) 3,52% 352 3 52 (3,52% <0,001 0001 001 demais Conclusões avaliada evidenciouse evidenciou 23 1 ≥1 (AGM (AGS <7 148 (14 62,9 [62,9% (28 17 (1 7,6 [7,6% 0,2 [0,2%] 026 =0,26 26 384 38,42 4 (38,42% 3,52 35 (3,52 <0,00 000 00 ≥ < 14 62, [62,9 (2 7, [7,6 0, [0,2% =0,2 38,4 (38,42 3,5 (3,5 <0,0 [62, [7, [0,2 =0, 38, (38,4 3, (3, <0, [62 [7 [0, =0 (38, (3 <0 [6 [ [0 = (38

Abstract Group I introns are small RNAs (250-500 nt) capable of catalyzing their own splicing from the precursor RNA. They are widely distributed across the tree of life and have intricate relationships with their host genomes. In this work, we review its basic structure, self-splicing and its mechanisms of gene mobility. As they are widely found in unicellular eukaryotes, especially fungi, we gathered information regarding their possible impact on the physiology of fungal cells and the possible application of these introns in medical mycology. 250500 250 500 (250-50 nt RNA genomes work structure selfsplicing self mobility eukaryotes fungi mycology 25050 25 50 (250-5 2505 2 5 (250- (250 (25 (2 (

ABSTRACT OBJECTIVE Evaluate and compare the protagonism of Oral Health teams (OHt) in the teamwork process in Primary Healthcare (PHC) over five years and estimate the magnitude of disparities between Brazilian macro-regions. METHODS Ecological study that used secondary data extracted from the Sistema de Informação em Saúde para a Atenção Básica (SISAB – Health Information System for Primary Healthcare) from 2018 to 2022. Indicators were selected from a previously validated evaluative matrix, calculated from records in the Collective Activity Form on the degree of OHt’s protagonism in team meetings and its degree of organization concerning the meeting agendas. A descriptive and amplitude analysis of the indicators’ variation over time was carried out, and the disparity index was also calculated to estimate and compare the magnitude of differences between macro-regions in 2022. RESULTS In Brazil, between 3.06% and 4.04% of team meetings were led by OHt professionals. The Northeast and South regions had the highest (3.71% to 4.88%) and lowest proportions (1.21% to 2.48%), respectively. From 2018 to 2022, there was a reduction in the indicator of the “degree of protagonism of the OHt” in Brazil and macro-regions. The most frequent topics in meetings under OHt’s responsibility were the work process (54.71% to 70.64%) and diagnosis and monitoring of the territory (33.49% to 54.48%). The most significant disparities between regions were observed for the indicator “degree of organization of the OHt concerning case discussion and singular therapeutic projects”. CONCLUSIONS The protagonism of the OHt in the teamwork process in PHC is incipient and presents regional disparities, which challenges managers and OHt to break isolation and lack of integration, aiming to offer comprehensive and quality healthcare to the user of the Unified Health System (SUS). (OHt (PHC macroregions. macroregions macro regions. SISAB 201 2022 matrix OHts s agendas indicators out 306 3 06 3.06 404 4 04 4.04 professionals 3.71% 371 71 (3.71 4.88% 488 88 1.21% 121 1 21 (1.21 2.48%, 248 2.48% , 2 48 2.48%) respectively 54.71% 5471 54 (54.71 70.64% 7064 70 64 33.49% 3349 33 49 (33.49 54.48%. 5448 54.48% . 54.48%) projects. projects projects” integration SUS. SUS (SUS) 20 202 30 0 3.0 40 4.0 3.71 37 7 (3.7 4.88 8 1.21 12 (1.2 24 2.48 54.71 547 5 (54.7 70.64 706 6 33.49 334 (33.4 544 54.48 (SUS 3. 4. 3.7 (3. 4.8 1.2 (1. 2.4 54.7 (54. 70.6 33.4 (33. 54.4 (3 1. (1 2. 54. (54 70. 33. (33 ( (5

RESUMO OBJETIVO Avaliar e comparar o protagonismo das equipes de Saúde Bucal (eSB) no processo de trabalho em equipe na Atenção Primária à Saúde (APS) ao longo de cinco anos, e estimar a magnitude das disparidades entre as macrorregiões brasileiras. MÉTODOS Estudo ecológico que utilizou dados secundários extraídos do Sistema de Informação em Saúde para a Atenção Básica (SISAB), de 2018 a 2022. Foram selecionados indicadores de matriz avaliativa previamente validada, calculados a partir dos registros na Ficha de Atividade Coletiva do grau de protagonismo das eSB nas reuniões de equipe, bem como do seu grau de organização em relação às pautas dos encontros. Foi realizada análise descritiva e da amplitude da variação dos indicadores ao longo do tempo, e também foi calculado o índice de disparidade para estimar e comparar a magnitude das diferenças entre as macrorregiões no ano de 2022. RESULTADOS No Brasil, entre 3,06% e 4,04% das reuniões de equipe foram lideradas por profissionais da eSB. No período, o Nordeste e o Sul foram as regiões que apresentaram maiores (3,71% a 4,88%) e menores proporções (1,21% a 2,48%), respectivamente. No período de 2018 a 2022, houve uma redução do indicador “grau de protagonismo das eSB” no Brasil e nas macrorregiões. Os temas mais frequentes em reuniões sob responsabilidade das eSB foram processo de trabalho (54,71% a 70,64%) e diagnóstico e monitoramento do território (33,49% a 54,48%). As maiores disparidades entre as regiões foram observadas para o indicador “grau de organização das eSB, em relação à discussão de caso e de projeto terapêutico singular”. CONCLUSÕES O protagonismo das eSB no processo de trabalho em equipe na APS é incipiente e apresenta disparidades regionais, o que desafia gestores e eSB para o rompimento do isolamento e da falta de integração, visando a oferta de atenção à saúde integral e de qualidade ao usuário do Sistema Único de Saúde (SUS). (eSB (APS anos brasileiras SISAB, SISAB , (SISAB) 201 2022 validada encontros tempo 306 3 06 3,06 404 4 04 4,04 3,71% 371 71 (3,71 4,88% 488 88 1,21% 121 1 21 (1,21 2,48%, 248 2,48% 2 48 2,48%) respectivamente 54,71% 5471 54 (54,71 70,64% 7064 70 64 33,49% 3349 33 49 (33,49 54,48%. 5448 54,48% . 54,48%) singular. singular singular” regionais integração SUS. SUS (SUS) (SISAB 20 202 30 0 3,0 40 4,0 3,71 37 7 (3,7 4,88 8 1,21 12 (1,2 24 2,48 54,71 547 5 (54,7 70,64 706 6 33,49 334 (33,4 544 54,48 (SUS 3, 4, 3,7 (3, 4,8 1,2 (1, 2,4 54,7 (54, 70,6 33,4 (33, 54,4 (3 1, (1 2, 54, (54 70, 33, (33 ( (5

Objective: We aimed to translate and determine cultural validity of the Vaginal Changes Sexual and Body Esteem Scale (VSBE) for Brazilian Portuguese language in postpartum women who underwent vaginal delivery with or without perineal laceration and cesarean section. Methods: A cross-sectional study conducted virtually, with online data collection through a survey with 234 postpartum women of 975 that were invited. Clinical, sociodemographic, and psychometric variables from the VSBE questionnaire were analyzed (content validity index, internal consistency, test-retest reliability, construct/structural and discriminant validity). Multivariate analysis was performed to explore associated factors with the presence of perineal laceration. Results: One-hundred fifty-eight women experienced vaginal delivery, of which 24.79% had an intact perineum, 33.33% had perineal laceration, and 9.4% underwent episiotomy; and 76 participants had cesarean sections. Women with perineal laceration were older, presented dyspareunia and previous surgeries than women without perineal laceration (p<0.05). For VSBE, a high internal consistency (Cronbach's α > 0.7) was observed, but it did not correlate with Body Attractiveness Questionnaire and Female Sexual Function Index; however, it correlated with the presence of women sutured for perineal laceration. Moreover, VSBE presented good structural validity with two loading factors after exploratory factor analysis. VSBE also demonstrated discriminant validity between the presence or absence of perineal laceration. The presence of urinary incontinence (UI) (OR=2.716[1.015-4.667];p=0.046) and a higher VSBE total score (OR=1.056[1.037-1.075];p<0.001) were the only factors associated with perineal laceration. Conclusion: Vaginal Changes Sexual and Body Esteem Scale demonstrated appropriate translation and good internal consistency, discriminant/construct validity and reliability. Vaginal Changes Sexual and Body Esteem Scale total score and presence of UI were associated with women that underwent perineal laceration. Objective (VSBE section Methods crosssectional cross sectional virtually 23 97 invited Clinical sociodemographic content index testretest test retest reliability constructstructural construct validity. . validity) Results Onehundred One hundred fiftyeight fifty eight 2479 24 79 24.79 perineum 3333 33 33.33 94 9 4 9.4 episiotomy 7 sections older p<0.05. p005 p p<0.05 0 05 (p<0.05) Cronbachs Cronbach s 0.7 07 observed Index however Moreover (UI OR=2.7161.0154.667p=0.046 OR271610154667p0046 ORp OR=2.716 1.015 4.667 p=0.046 OR 2 716 1 015 667 046 (OR=2.716[1.015-4.667];p=0.046 OR=1.0561.0371.075p<0.001 OR105610371075p0001 OR=1.056 1.037 1.075 p<0.001 056 037 075 001 (OR=1.056[1.037-1.075];p<0.001 Conclusion discriminantconstruct 247 24.7 333 3 33.3 9. p00 p<0.0 (p<0.05 0. 7161 0154 667p OR=2.7161.0154.667p=0.04 OR271610154667p004 OR2716 OR=2.71 1015 1.01 4667 4.66 p0046 p=0.04 71 01 66 04 (OR=2.716[1.015-4.667];p=0.04 0561 0371 075p OR=1.0561.0371.075p<0.00 OR105610371075p000 OR1056 OR=1.05 1037 1.03 1075 1.07 p0001 p<0.00 03 00 (OR=1.056[1.037-1.075];p<0.00 24. 33. p0 p<0. (p<0.0 OR=2.7161.0154.667p=0.0 OR271610154667p00 OR271 OR=2.7 101 1.0 466 4.6 p004 p=0.0 6 (OR=2.716[1.015-4.667];p=0.0 OR=1.0561.0371.075p<0.0 OR105610371075p00 OR105 OR=1.0 103 107 p000 (OR=1.056[1.037-1.075];p<0.0 p<0 (p<0. OR=2.7161.0154.667p=0. OR271610154667p0 OR27 OR=2. 10 1. 46 4. p=0. (OR=2.716[1.015-4.667];p=0. OR=1.0561.0371.075p<0. OR105610371075p0 OR10 OR=1. (OR=1.056[1.037-1.075];p<0. p< (p<0 OR=2.7161.0154.667p=0 OR271610154667p OR2 OR=2 p=0 (OR=2.716[1.015-4.667];p=0 OR=1.0561.0371.075p<0 OR105610371075p OR1 OR=1 (OR=1.056[1.037-1.075];p<0 (p< OR=2.7161.0154.667p= OR= p= (OR=2.716[1.015-4.667];p= OR=1.0561.0371.075p< (OR=1.056[1.037-1.075];p< (p OR=2.7161.0154.667p (OR=2.716[1.015-4.667];p OR=1.0561.0371.075p (OR=1.056[1.037-1.075];p

Abstract Chemotherapy stands out as the main systemic treatment strategy against cancer and still faces problems related to multidrug resistance and severe side effects. Copper-based drugs have been widely explored in medicinal chemistry, since copper is an essential metal for physiological activities with antineoplastic effects. In this context, the present study aimed to evaluate the recombinogenic/mutagenic and anticarcinogenic potential of the complex CBP-01 - [Cu(bta)(1,10-phen)ClO4] (Hbta = 4,4,4-trifluoro-1-phenyl-1,3-butanedione and 1,10-phen =1,10-phenanthroline) - through the Somatic and Recombination test (SMART) and the Epithelial Tumor Test (ETT) in Drosophila melanogaster, compared with carboplatin (CARB) and cisplatin (CIS) effects. According to our results, CARB and CIS induced a high frequency of mutant spots, which was not verified at higher concentrations of CBP-01. In addition, CBP-01 exhibited mutagenic/recombinogenic potential only at the lowest concentration and after biometabolization. Subsequently, in the ETT test, CBP-01 did not demonstrate carcinogenic effect. Lastly, epithelial tumors were identified in flies treated with CARB and CIS, which were modulated by the CBP-01 complex. Therefore, CBP-01 modulates genotoxicity of other compounds and is a promising metal-based drug for the development of a new anticancer agent or for optimization of therapeutic regimens. effects Copperbased Copper based chemistry context recombinogenicmutagenic recombinogenic mutagenic CBP01 CBP 01 CBP-0 Cubta1,10phenClO4 Cubta110phenClO4 CubtaphenClO Cu bta 1,10 phen ClO4 1 10 ClO [Cu(bta)(1,10-phen)ClO4 Hbta 4,4,4trifluoro1phenyl1,3butanedione 444trifluoro1phenyl13butanedione trifluorophenylbutanedione 4,4,4 trifluoro phenyl 1,3 butanedione 4 3 1,10phen 110phen =1,10phenanthroline 110phenanthroline phenanthroline =1,10 =1,10-phenanthroline SMART (SMART (ETT melanogaster (CARB (CIS results spots CBP01. 01. addition mutagenicrecombinogenic biometabolization Subsequently effect Lastly Therefore metalbased regimens CBP0 0 CBP- Cubta1 10phenClO4 Cubta phenClO Cubta1,10phenClO Cubta110phenClO 110 1,1 [Cu(bta)(1,10-phen)ClO 4trifluoro1phenyl1 3butanedione 444 4,4, 13 1, 10phen 10phenanthroline =1,1 10phenClO 11 trifluorophenyl 4trifluoro1phenyl 44 4,4 =1, 4, =1

Abstract: The influenza-like illness (ILI) sentinel surveillance operates in Brazil to identify respiratory viruses of public health relevance circulating in the country and was first implemented in 2000. Recently, the COVID-19 pandemic reinforced the importance of early detection of the circulation of new viruses in Brazil. Therefore, an analysis of the design of the ILI sentinel surveillance is timely. To this end, we simulated a sentinel surveillance network, identifying the municipalities that would be part of the network according to the criteria defined in the design of the ILI sentinel surveillance and, based on data from tested cases of severe acute respiratory illness (SARI) from 2014 to 2019, we drew samples for each sentinel municipality per epidemiological week. The draw was performed 1,000 times, obtaining the median and 95% quantile interval (95%QI) of virus positivity by Federative Unit and epidemiological week. According to the ILI sentinel surveillance design criteria, sentinel units would be in 64 municipalities, distributed mainly in capitals and their metropolitan areas, recommending 690 weekly samples. The design showed good sensitivity (91.65% considering the 95%QI) for qualitatively detecting respiratory viruses, even those with low circulation. However, there was important uncertainty in the quantitative estimate of positivity, reaching at least 20% in 11.34% of estimates. The results presented here aim to assist in evaluating and updating the ILI sentinel surveillance design. Strategies to reduce uncertainty in positivity estimates need to be evaluated, as does the need for greater spatial coverage. Abstract influenzalike influenza like (ILI 2000 Recently COVID19 COVID 19 COVID-1 Therefore timely end SARI (SARI 201 2019 week 1000 1 000 1,00 times 95 95%QI 95QI QI (95%QI 6 areas 69 91.65% 9165 91 65 (91.65 However 20 1134 11 34 11.34 evaluated coverage 200 COVID1 COVID- 100 00 1,0 9 91.65 916 (91.6 2 113 3 11.3 10 0 1, 91.6 (91. 11. 91. (91 (9 (

Resumen: La vigilancia centinela de la enfermedad tipo infuenza (ETI) funciona en Brasil para identificar los virus respiratorios de importancia para la salud pública que circulan en el país y comenzó a ser implementada en 2000. Recientemente, la pandemia de COVID-19 ha reforzado la importancia de la detección temprana de la circulación de nuevos virus en el territorio brasileño. Así, se hace oportuno un análisis del diseño de la vigilancia centinela de la ETI. Para ello, simulamos una red centinela identificando los municipios que formarían parte de la red según los criterios definidos en el diseño de la vigilancia centinela de la ETI y, a partir de los datos de casos testados de infección respiratoria aguda grave (IRAG) de 2014 a 2019, se extrajeron muestras para cada municipio centinela por semana epidemiológica. El sorteo se repitió 1.000 veces y se obtuvo la mediana y el intervalo cuantílico del 95% (IC95%) de la positividad por virus, por Unidad Federativa y semana epidemiológica. Según los criterios del diseño de la vigilancia centinela de la ETI, unidades centinelas estarían en 64 municipios, distribuidas principalmente en capitales y zonas metropolitanas de las capitales, preconizando 690 muestras semanales. El diseño presentó una buena sensibilidad (total de 91,65% considerando el IC95%) para la detección cualitativa de los virus respiratorios, incluso los de baja circulación. Sin embargo, hubo una importante incertidumbre en la estimación cuantitativa de la positividad, alcanzando al menos el 20% en el 11,34% de las estimaciones. Los resultados presentados aquí tienen como objetivo ayudar en la evaluación y actualización del diseño de la red centinela. Es necesario evaluar las estrategias para reducir la incertidumbre en las estimaciones de positividad, al igual que la necesidad de una mayor cobertura espacial. Resumen (ETI 2000 Recientemente COVID19 COVID 19 COVID-1 brasileño Así ello IRAG (IRAG 201 2019 epidemiológica 1000 1 000 1.00 95 IC95% IC95 IC (IC95% 6 69 semanales total 9165 91 65 91,65 embargo 20 1134 11 34 11,34 espacial 200 COVID1 COVID- 100 00 1.0 9 IC9 (IC95 916 91,6 2 113 3 11,3 10 0 1. (IC9 91, 11, (IC

Resumo: A vigilância sentinela de síndrome gripal atua no Brasil identificando os vírus respiratórios de importância para a saúde pública circulantes no país, e começou a ser implementada em 2000. Recentemente, a pandemia de COVID-19 reforçou a importância da detecção precoce de novos vírus em circulação no território brasileiro. Assim, se faz oportuna uma análise do desenho da vigilância sentinela de síndrome gripal. Para tal, simulamos uma rede sentinela, identificando os municípios que fariam parte da rede segundo os critérios definidos no desenho da vigilância sentinela de síndrome gripal, e, a partir dos dados de casos testados de síndrome respiratória aguda grave (SRAG) de 2014 a 2019, sorteamos amostras para cada município sentinela por semana epidemiológica. O sorteio foi repetido mil vezes, obtendo-se a mediana e intervalo quantílico de 95% (IQ95%) da positividade para cada vírus por Unidade Federativa e semana epidemiológica. Segundo os critérios do desenho da vigilância sentinela de síndrome gripal, unidades sentinelas estariam em 64 municípios, distribuídas principalmente em capitais e suas zonas metropolitanas, o que preconizou 690 amostras semanais. O desenho apresentou boa sensibilidade (total de 91,65%, considerando o IQ95%) para a detecção qualitativa dos vírus respiratórios, mesmo os de baixa circulação. Porém, houve importante incerteza na estimativa quantitativa de positividade, chegando a, pelo menos, 20% em 11,34% das estimativas. Os resultados aqui apresentados visam auxiliar a avaliação e a atualização do desenho da rede sentinela. Estratégias para reduzir a incerteza nas estimativas de positividade precisam ser avaliadas, assim como a necessidade de maior cobertura espacial. Resumo país 2000 Recentemente COVID19 COVID 19 COVID-1 brasileiro Assim tal SRAG (SRAG 201 2019 epidemiológica vezes obtendose obtendo 95 IQ95% IQ95 IQ (IQ95% 6 metropolitanas 69 semanais total 9165 91 65 91,65% Porém menos 20 1134 11 34 11,34 avaliadas espacial 200 COVID1 1 COVID- 9 IQ9 (IQ95 916 91,65 2 113 3 11,3 (IQ9 91,6 11, (IQ 91,

Resumo Antecedentes A disfunção olfatória (DO) é uma manifestação frequente da doença do coronavírus 2019 (COVID-19). A apolipoproteína E (APOE) é uma proteína que interage com o receptor da enzima conversora de angiotensina, essencial para a entrada viral na célula. Publicações anteriores sugeriram um possível papel da APOE na gravidade da COVID-19. Até onde sabemos, nenhuma publicação encontrou associações significativas entre a gravidade dessa doença, DO e polimorfismos da APOE (E2, E3 e E4). Objetivo Analisar a epidemiologia da DO e sua relação com os polimorfismos do gene APOE em uma coorte de pacientes com COVID longa. Métodos Um estudo de coorte prospectiva com pacientes acompanhados em ambulatório neurológico pós-COVID, com DO sendo definida como uma redução subjetiva da função olfativa após a infecção e a DO persistente sendo definida quando a queixa durou mais de 3 meses após a resolução da infecção por COVID-19. Este estudo transversal é parte de uma pesquisa maior com dados anteriormente relatados, focando na performance cognitiva dos pacientes. Resultados Foram selecionados 221 pacientes para esse estudo, dos quais 186 haviam coletado amostras de sangue para genotipagem APOE. O grupo DO persistente foi mais jovem e apresentou menor taxa de internação na fase aguda da doença (p < 0,001). Além disso, a frequência do alelo E4 da APOE foi menor nesse grupo (p = 0,035). Este estudo avaliou a DO em uma população com COVID longa. Na literatura atual sobre essa doença, a anosmia está associada a melhores desfechos clínicos e o alelo E4 está associado a piores desfechos. Conclusão Nosso estudo acrescenta novas informações a essas correlações, sugerindo a APOE E4 como um fator de proteção para DO. (DO 201 COVID19. COVID19 19 . (COVID-19) (APOE angiotensina célula 19. COVID-19 sabemos E2, E2 (E2 E4. E4) longa pósCOVID, pósCOVID pós COVID, pós-COVID relatados 22 18 p 0,001. 0001 0,001 0 001 0,001) disso 0,035. 0035 0,035 035 0,035) correlações 20 COVID1 1 (COVID-19 COVID-1 (E 2 000 0,00 00 003 0,03 03 (COVID-1 COVID- 0,0 (COVID- 0, (COVID

Abstract Background Olfactory dysfunction (OD) represents a frequent manifestation of the coronavirus disease 2019 (COVID-19). Apolipoprotein E (APOE) is a protein that interacts with the angiotensin-converting enzyme receptor, essential for viral entry into the cell. Previous publications have suggested a possible role of APOE in COVID-19 severity. As far as we know, no publications found significant associations between this disease's severity, OD, and APOE polymorphisms (E2, E3, and E4). Objective To analyze the epidemiology of OD and its relationship with APOE polymorphisms in a cohort of Long-COVID patients. Methods We conducted a prospective cohort study with patients followed in a post-COVID neurological outpatient clinic, with OD being defined as a subjective reduction of olfactory function after infection, and persistent OD being defined when the complaint lasted more than 3 months after the COVID-19 infection resolution. This cross-sectional study is part of a large research with previously reported data focusing on the cognitive performance of our sample. Results The final sample comprised 221 patients, among whom 186 collected blood samples for APOE genotyping. The persistent OD group was younger and had a lower hospitalization rate during the acute phase of the disease (p < 0.001). Furthermore, the APOE variant E4 allele frequency was lower in this group (p = 0.035). This study evaluated OD in an outpatient population with COVID-19. In the current literature on this disease, anosmia is associated with better clinical outcomes and the E4 allele is associated with worse outcomes. Conclusion Our study provides new information to these correlations, suggesting APOE E4 as a protective factor for OD. (OD 201 COVID19. COVID19 COVID 19 . (COVID-19) (APOE angiotensinconverting angiotensin converting receptor cell COVID-1 severity know diseases s E2, E2 (E2 E3 E4. E4) LongCOVID Long postCOVID post clinic resolution crosssectional cross sectional 22 18 genotyping p 0.001. 0001 0.001 0 001 0.001) Furthermore 0.035. 0035 0.035 035 0.035) 19. correlations 20 COVID1 1 (COVID-19 COVID- (E 2 000 0.00 00 003 0.03 03 (COVID-1 0.0 (COVID- 0. (COVID

ABSTRACT Purpose to analyze how socioeconomic, pregnancy and childbirth factors relate to the feeding situation in the sixth month of life of full-term babies. Methods longitudinal observational study, with 98 mothers of full-term babies. Data collection was structured by capturing information regarding the clinical history and moment of birth in the babies' medical records, followed by the application of two questionnaires to the postpartum women, with questions regarding sociodemographic data, pre- and post-pregnancy data and the baby's nutrition. baby, the first being answered during hospital stay and the second, by telephone, in the 6th month of life. A descriptive analysis of the data was performed, using the frequency distribution of categorical variables, inferential analysis using Pearson's Chi-square test and multivariate analysis using binary logistic regression, adopting, for inclusion in the final model, the significance level of 5%. Results there was an association between exclusive breastfeeding in the 6th month and maternal education and between the period of food introduction and family income. Mothers with higher education were 4.82 times more likely to breastfeed their children exclusively until the sixth month. Families with lower income (up to one minimum wage) were 2.54 times more likely to start food introduction before the sixth month than families with higher income. Conclusion higher maternal education was a predictive factor for exclusive breastfeeding at the 6th month and higher military income was a predictive factor for introducing food after the 6th month. socioeconomic fullterm full term babies study 9 records women pre postpregnancy post babys baby s nutrition second telephone th performed variables Pearsons Pearson Chisquare Chi square regression adopting model 5 5% 482 4 82 4.8 up wage 254 2 54 2.5 48 8 4. 25 2.

RESUMO Objetivo analisar como os fatores socioeconômicos, da gestação e do parto se relacionam com a situação da alimentação no sexto mês de vida de bebês nascidos a termo. Método estudo observacional longitudinal, com 98 mães de bebês termos. A coleta de dados foi estruturada pela captação das informações referentes à história clínica e ao momento do parto nos prontuários dos bebês, seguida da aplicação de dois questionários, com questões referentes a dados sociodemográficos, dados pré e pós-gestacionais e da alimentação do bebê, sendo o primeiro respondido durante a internação hospitalar e o segundo, por contato telefônico, no 6° mês de vida. Foi realizada análise descritiva dos dados, por meio da distribuição de frequência das variáveis categóricas, análise inferencial utilizando o teste Qui-quadrado de Pearson e análise multivariada por regressão logística binária, adotando-se, para inclusão no modelo final, o nível de significância de 5%. Resultados houve associação entre aleitamento materno exclusivo no 6º mês e escolaridade materna e entre o início da introdução alimentar e a renda familiar. Mães com ensino superior apresentaram 4,82 vezes mais chances de amamentarem os filhos de forma exclusiva até o sexto mês. Famílias de menor renda (até um salário mínimo) tiveram 2,54 vezes mais chances de iniciarem a introdução alimentar antes do sexto mês do que as famílias de maior renda. Conclusão maior escolaridade materna foi fator preditor para o aleitamento materno exclusivo ao 6º mês e maior renda familiar foi fator preditor para introdução alimentar após o 6º mês. socioeconômicos termo longitudinal 9 termos questionários sociodemográficos pósgestacionais pós gestacionais bebê segundo telefônico 6 categóricas Quiquadrado Qui quadrado binária adotandose, adotandose adotando se, adotando-se final 5 5% º 482 4 82 4,8 mínimo 254 2 54 2,5 48 8 4, 25 2,

Abstract This article aims to analyze the morbimortality of COVID-19 in Brazil, according to race/color aspects, problematizing the concept of race as a structuring factor for equitable care in the pandemic. Exploratory and reflective research, with analysis of 43 epidemiological bulletins and 15 articles selected from a narrative literature review. We discuss elements concerning critical social epidemiology, intersectionality, and necropolitics, in the face of health inequities. The results indicate that in a society intersected by racism, sexism, and poverty, the risk, incidence, and mortality of the disease are socially unequal, given that the black, poor, and peripheral city population has higher epidemiological indices. A State with necropolitical technologies is revealed, with the pandemic being another modus to produce death. It concludes by evoking the insurgency of a complex epidemiology of COVID-19, combining health policies with social protection and economic development. COVID19 COVID 19 COVID-1 Brazil racecolor color aspects research 4 1 review intersectionality necropolitics inequities racism sexism poverty risk incidence unequal black poor indices revealed death COVID19, 19, development COVID1 COVID-

Resumo Este artigo pretende analisar a morbimortalidade da Covid-19 no Brasil, segundo quesito raça/cor, problematizando o conceito de raça como estruturante para uma atenção equânime na pandemia. Trata-se de uma pesquisa exploratória e reflexiva, com análise de 43 boletins epidemiológicos e 15 artigos selecionados a partir de uma revisão narrativa de literatura. Discutimos elementos concernentes à epidemiologia social crítica, interseccionalidade e necropolítica, ante as iniquidades em saúde. Os resultados apontam que numa sociedade interseccionalizada por racismo, sexismo e pobreza, o risco, a incidência e a mortalidade da doença são socialmente desiguais, haja vista a população negra, pobre e periférica, apresentar maiores índices epidemiológicos. Desvela-se um Estado com tecnologias necropolíticas governamentais, sendo a pandemia mais um modus de produzir a morte. Conclui-se evocando a insurgência de uma epidemiologia complexa da Covid-19, aliando políticas de saúde à proteção social e ao desenvolvimento econômico. Covid19 Covid 19 Covid-1 Brasil raçacor cor raça/cor Tratase Trata se reflexiva 4 1 literatura crítica necropolítica racismo pobreza risco desiguais negra periférica Desvelase Desvela governamentais morte Concluise Conclui Covid19, 19, econômico Covid1 Covid-

In this work, electrochemical tests were performed to measure hydrogen permeation during free dissolution of carbon steel in the presence of the ionic liquids (ILs) 1-ethyl-3-methylimidazolium acetate [(EMIM)+(Ac)-], 1-ethyl-3-methylimidazolium bromide [(EMIM)+(Br)-], and 1-butyl-3-methylimidazolium tetrafluoroborate [(BMIM)+(BF4)-] in 5.4 mol L-1 HCl aqueous solution. The permeation inhibition efficiencies (IEp (%)) of 5-hydroxy-2-nitromethylene-hexahydropyrimidine (HPY) and a commercial corrosion inhibitor (CCI) were also evaluated. Among the ILs, the (BMIM)+(BF4)- compound presented the highest corrosion and hydrogen permeation inhibition efficiencies, with values of 23% and 30%, respectively. The (EMIM)+(Br)- and (EMIM)+(Ac)- compounds were not effective against corrosion, but they presented IEp of 15.8% and 23%, respectively. The HPY compound demonstrated 61% effectiveness in preventing corrosion, while in silico evaluation indicated no toxicity. However, neither the HPY compound nor the CCI compound inhibited the entry of hydrogen into the carbon steel during the pickling process. work ILs (ILs 1ethyl3methylimidazolium ethylmethylimidazolium 1 ethyl 3 methylimidazolium EMIM+Ac, EMIMAc EMIM + Ac , [(EMIM)+(Ac)-] EMIM+Br, EMIMBr Br [(EMIM)+(Br)-] 1butyl3methylimidazolium butylmethylimidazolium butyl BMIM+BF4 BMIMBF4 BMIMBF BMIM BF4 BF [(BMIM)+(BF4)- 54 5 4 5. L1 L L- solution % (%) 5hydroxy2nitromethylenehexahydropyrimidine hydroxynitromethylenehexahydropyrimidine hydroxy 2 nitromethylene hexahydropyrimidine (HPY (CCI evaluated (BMIM)+(BF4) 23 30 30% respectively EMIM+Br (EMIM)+(Br) EMIM+Ac (EMIM)+(Ac) 158 15 8 15.8 61 toxicity However process [(EMIM)+(Ac)- [(EMIM)+(Br)- BMIM+BF [(BMIM)+(BF4) (% nitromethylenehexahydropyrimidine (BMIM)+(BF4 (EMIM)+(Br (EMIM)+(Ac 15. 6 [(EMIM)+(Ac) [(EMIM)+(Br) [(BMIM)+(BF4 ( (BMIM)+(BF [(EMIM)+(Ac [(EMIM)+(Br [(BMIM)+(BF