Resumen Objetivo: Estabelecer un protocolo utilizado para la realización de autopsias mínimamente invasivas (AMI) para la detección de muertes por arbovirus y presentar datos preliminares de este protocolo en Ceará, Brasil. Métodos: Se llevó a cabo la capacitación de médicos patólogos en AMI. Resultados: Se estableció un protocolo para la realización de AMI, que define los criterios para la toma de muestras, métodos de almacenamiento y diagnóstico; en tres meses se realizaron 43 AMI; de estas, 21 (48,8%) llegaron al Servicio de Verificación de Óbito (SVO) con una hipótesis diagnóstica de alguna arbovirosis y siete (16,3%) fueron confirmadas (seis casos de chikungunya y uno de dengue); también se confirmaron casos de Covid-19 (n = 9), tuberculosis (n = 5), meningitis (n = 4), criptococosis (n = 1), enfermedad de Creutzfeldt-Jakob (n = 1), neoplasia de mama (n = 1) y rabia humana (n = 1). Conclusión: El protocolo implementado permitió la identificación de un mayor número de muertes sospechosas de arbovirus, además de la confirmación de otras patologías de interés. Objetivo AMI (AMI Ceará Brasil Métodos Resultados muestras diagnóstico 4 estas 2 48,8% 488 48 8 (48,8% SVO (SVO 16,3% 163 16 3 (16,3% seis dengue dengue) Covid19 Covid 19 Covid-1 n 9, 9 , 9) 5, 5 5) 4, 4) 1, 1 CreutzfeldtJakob Creutzfeldt Jakob 1. . Conclusión interés 48,8 (48,8 16,3 (16,3 Covid1 Covid- 48, (48, 16, (16, (48 (16 (4 (1 (

Abstract Objective: To create a protocol for performing minimally invasive autopsies (MIA) in detecting deaths from arboviruses and report preliminary data from its application in Ceará state, Brazil. Methods: Training was provided to medical pathologists on MIA. Results: A protocol was established for performing MIA, defining criteria for sample collection, storage methods, and diagnoses to be carried out according to the type of biological sample; 43 MIAs were performed in three months. Of these, 21 (48.8%) arrived at the Death Verification Service (SVO) with arboviruses as a diagnostic hypothesis, and seven (16.3%) were confirmed (six chikungunya cases and one dengue case); cases of COVID-19 (n = 9), tuberculosis (n = 5), meningitis (n = 4), cryptococcosis (n = 1), Creutzfeldt-Jakob disease (n = 1), breast cancer (n = 1), and human rabies (n = 1) were also confirmed. Conclusion: The protocol implemented enabled identification of a larger number of suspected arbovirus-related deaths, as well as confirmation of other diseases of interest for surveillance. Objective MIA (MIA state Brazil Methods Results collection methods 4 months these 2 48.8% 488 48 8 (48.8% SVO (SVO hypothesis 16.3% 163 16 3 (16.3% six case case) COVID19 COVID 19 COVID-1 n 9, 9 , 9) 5, 5 5) 4, 4) 1, 1 CreutzfeldtJakob Creutzfeldt Jakob Conclusion arbovirusrelated arbovirus related surveillance 48.8 (48.8 16.3 (16.3 COVID1 COVID- 48. (48. 16. (16. (48 (16 (4 (1 (

Resumo Objetivo: Estabelecer protocolo para realização de autópsias minimamente invasivas (AMIs) na detecção de óbitos por arboviroses e relatar dados preliminares desse protocolo no Ceará, Brasil. Métodos: Médicos patologistas foram treinados em AMI. Resultados: Estabeleceu-se protocolo para AMI, definindo-se critérios para amostras a serem coletadas, suas formas de armazenamento e diagnóstico, segundo o tipo de amostra biológica; em três meses, foram realizadas 43 AMIs, das quais 21 (48,8%) chegaram ao Serviço de Verificação de Óbito (SVO) com hipótese diagnóstica de alguma arbovirose e sete (16,3%) foram confirmados (seis de chikungunya; uma de dengue); também foram confirmados casos de covid-19 (n = 9), tuberculose (n = 5), meningite (n = 4), criptococose (n = 1), doença de Creutzfeldt-Jakob (n = 1), neoplasia de mama (n = 1) e raiva humana (n = 1). Conclusão: O protocolo implantado permitiu a captação de um maior número de óbitos suspeitos de arboviroses, além da confirmação de outras patologias de interesse da vigilância. Objetivo AMIs (AMIs Ceará Brasil Métodos AMI Resultados Estabeleceuse Estabeleceu se definindose definindo coletadas diagnóstico biológica meses 4 2 48,8% 488 48 8 (48,8% SVO (SVO 16,3% 163 16 3 (16,3% seis chikungunya dengue dengue) covid19 covid 19 covid-1 n 9, 9 , 9) 5, 5 5) 4, 4) 1, 1 CreutzfeldtJakob Creutzfeldt Jakob 1. . Conclusão vigilância 48,8 (48,8 16,3 (16,3 covid1 covid- 48, (48, 16, (16, (48 (16 (4 (1 (

Resumo Objetivo: Estabelecer protocolo para realização de autópsias minimamente invasivas (AMIs) na detecção de óbitos por arboviroses e relatar dados preliminares desse protocolo no Ceará, Brasil. Métodos: Médicos patologistas foram treinados em AMI. Resultados: Estabeleceu-se protocolo para AMI, definindo-se critérios para amostras a serem coletadas, suas formas de armazenamento e diagnóstico, segundo o tipo de amostra biológica; em três meses, foram realizadas 43 AMIs, das quais 21 (48,8%) chegaram ao Serviço de Verificação de Óbito (SVO) com hipótese diagnóstica de alguma arbovirose e sete (16,3%) foram confirmados (seis de chikungunya; uma de dengue); também foram confirmados casos de covid-19 (n = 9), tuberculose (n = 5), meningite (n = 4), criptococose (n = 1), doença de Creutzfeldt-Jakob (n = 1), neoplasia de mama (n = 1) e raiva humana (n = 1). Conclusão: O protocolo implantado permitiu a captação de um maior número de óbitos suspeitos de arboviroses, além da confirmação de outras patologias de interesse da vigilância.

Abstract Objective: To create a protocol for performing minimally invasive autopsies (MIA) in detecting deaths from arboviruses and report preliminary data from its application in Ceará state, Brazil. Methods: Training was provided to medical pathologists on MIA. Results: A protocol was established for performing MIA, defining criteria for sample collection, storage methods, and diagnoses to be carried out according to the type of biological sample; 43 MIAs were performed in three months. Of these, 21 (48.8%) arrived at the Death Verification Service (SVO) with arboviruses as a diagnostic hypothesis, and seven (16.3%) were confirmed (six chikungunya cases and one dengue case); cases of COVID-19 (n = 9), tuberculosis (n = 5), meningitis (n = 4), cryptococcosis (n = 1), Creutzfeldt-Jakob disease (n = 1), breast cancer (n = 1), and human rabies (n = 1) were also confirmed. Conclusion: The protocol implemented enabled identification of a larger number of suspected arbovirus-related deaths, as well as confirmation of other diseases of interest for surveillance.

Resumen Objetivo: Estabelecer un protocolo utilizado para la realización de autopsias mínimamente invasivas (AMI) para la detección de muertes por arbovirus y presentar datos preliminares de este protocolo en Ceará, Brasil. Métodos: Se llevó a cabo la capacitación de médicos patólogos en AMI. Resultados: Se estableció un protocolo para la realización de AMI, que define los criterios para la toma de muestras, métodos de almacenamiento y diagnóstico; en tres meses se realizaron 43 AMI; de estas, 21 (48,8%) llegaron al Servicio de Verificación de Óbito (SVO) con una hipótesis diagnóstica de alguna arbovirosis y siete (16,3%) fueron confirmadas (seis casos de chikungunya y uno de dengue); también se confirmaron casos de Covid-19 (n = 9), tuberculosis (n = 5), meningitis (n = 4), criptococosis (n = 1), enfermedad de Creutzfeldt-Jakob (n = 1), neoplasia de mama (n = 1) y rabia humana (n = 1). Conclusión: El protocolo implementado permitió la identificación de un mayor número de muertes sospechosas de arbovirus, además de la confirmación de otras patologías de interés.

ABSTRACT BACKGROUND AND OBJECTIVES: The complexity of chronic musculoskeletal pain requires the need to know the treatment strategies from the perspective of the service user. The objective of this study was to analyze the satisfaction and perception of individuals with chronic musculoskeletal pain participating in a pain neuroscience education program in the online and face-to-face modalities. METHODS: This is a cross-sectional observational study, composed of 26 participants, of which 13 individuals participated in 10 meetings of face-to-face pain education (FG), and the other 13 in the online modality (OG). The satisfaction assessment consisted of 10 questions from the MedRisk Instrument for Measuring Patient Satisfaction With Physical Therapy Care, and the perception assessment was obtained by means of seven questions developed by the researchers, specific about the pain education program. For statistical analysis, Mann-Whitnney and chi square tests, Biostat software and significance level (0.05) were used. RESULTS: Of the 17 questions, there was a difference between the groups in only 5 questions. The FG reported greater satisfaction and perception in the questions of “explanation about the treatment received” (Chi2=6.19; p=0.05), “ways to avoid future problems” (Chi2=4.727; p=0.03), “return to future services” (Chi2=4.727; p=0.03), “relationship with other people” (10 vs 8; p=0.03) and “increased level of physical activity” (9 vs 8; p=0.03). CONCLUSION: There was good satisfaction and perception of individuals with chronic musculoskeletal pain participating in a pain neuroscience education program both in the online and face-to-face modality. Some differences were observed between both, especially in issues that seem to involve face-to-face contact with a professional, with more positive results in the FG. OBJECTIVES user facetoface face modalities METHODS crosssectional cross sectional 2 participants 1 FG, , (FG) OG. OG . (OG) Care researchers analysis MannWhitnney Mann Whitnney tests 0.05 005 0 05 (0.05 used RESULTS explanation received Chi2=6.19 Chi2619 Chi Chi2 6 19 (Chi2=6.19 p=0.05, p005 p p=0.05 p=0.05) ways problems Chi2=4.727 Chi24727 4 727 (Chi2=4.727 p=0.03, p003 p=0.03 03 return services relationship people (1 8 increased activity 9 ( p=0.03. CONCLUSION professional (FG (OG 0.0 00 (0.0 Chi2=6.1 Chi261 (Chi2=6.1 p00 p=0.0 Chi2=4.72 Chi2472 72 (Chi2=4.72 0. (0. Chi2=6. Chi26 (Chi2=6. p0 p=0. Chi2=4.7 Chi247 7 (Chi2=4.7 (0 Chi2=6 (Chi2=6 p=0 Chi2=4. Chi24 (Chi2=4. Chi2= (Chi2= p= Chi2=4 (Chi2=4 (Chi2 (Chi

RESUMO JUSTIFICATIVA E OBJETIVOS: A complexidade da dor musculoesquelética crônica exige a necessidade de conhecer as estratégias de tratamento sob a perspectiva do usuário do serviço. O objetivo deste estudo foi analisar a satisfação e a percepção de indivíduos com dor musculoesquelética crônica sobre um programa de educação em neurociência dor nas modalidades online e presencial. MÉTODOS: Trata-se de um estudo observacional do tipo transversal, composto por 26 participantes, dos quais 13 indivíduos participaram de 10 encontros de educação em dor presencial (GP), e os outros 13 na modalidade online (GO). A avaliação da satisfação consistiu em 10 questões do MedRisk Instrument for Measuring Patient Satisfaction With Physical Therapy Care, e a avaliação da percepção foi obtida por meio de sete perguntas desenvolvidas pelos pesquisadores, específicas sobre o programa de educação em dor. Para análise estatística, foram utilizados os testes de Mann-Whitney e Qui-quadrado, software Biostat e nível de significância ≤0,05. RESULTADOS: Das 17 questões, houve diferença entre os grupos apenas em 5 questões. O GP relatou maior satisfação e percepção nas questões que se referem a “explicação sobre o tratamento recebido” (Qui2=6,19; p=0,05), “formas de evitar futuros problemas” (Qui2=4,727; p=0,03), “retorno para futuros serviços” (Qui2=4,727; p=0,03), “relacionamento com outras pessoas” (10 vs 8; p=0,03) e “aumento do nível de atividade física” (9 vs 8; p=0,03). CONCLUSÃO: Indivíduos com dor musculoesquelética crônica mostraram boa satisfação e percepção de um programa de educação em neurociência da dor tanto na modalidade online quanto na presencial. Algumas diferenças foram observadas entre ambas, sobretudo nas questões que parecem envolver contato face-a-face com um profissional, com resultados mais positivos quando o programa é oferecido de forma presencial. OBJETIVOS serviço MÉTODOS Tratase Trata transversal 2 participantes 1 GP, , (GP) GO. GO . (GO) Care pesquisadores estatística MannWhitney Mann Whitney Quiquadrado, Quiquadrado Qui quadrado, quadrado Qui-quadrado 005 0 05 ≤0,05 RESULTADOS explicação recebido Qui2=6,19 Qui2619 Qui2 6 19 (Qui2=6,19 p=0,05, p005 p p=0,05 p=0,05) formas problemas Qui2=4,727 Qui24727 4 727 (Qui2=4,727 p=0,03, p003 p=0,03 03 retorno serviços relacionamento pessoas (1 8 aumento física 9 ( p=0,03. CONCLUSÃO ambas faceaface face profissional (GP (GO 00 ≤0,0 Qui2=6,1 Qui261 (Qui2=6,1 p00 p=0,0 Qui2=4,72 Qui2472 72 (Qui2=4,72 ≤0, Qui2=6, Qui26 (Qui2=6, p0 p=0, Qui2=4,7 Qui247 7 (Qui2=4,7 ≤0 Qui2=6 (Qui2=6 p=0 Qui2=4, Qui24 (Qui2=4, ≤ Qui2= (Qui2= p= Qui2=4 (Qui2=4 (Qui2 (Qui

RESUMO JUSTIFICATIVA E OBJETIVOS: A complexidade da dor musculoesquelética crônica exige a necessidade de conhecer as estratégias de tratamento sob a perspectiva do usuário do serviço. O objetivo deste estudo foi analisar a satisfação e a percepção de indivíduos com dor musculoesquelética crônica sobre um programa de educação em neurociência dor nas modalidades online e presencial. MÉTODOS: Trata-se de um estudo observacional do tipo transversal, composto por 26 participantes, dos quais 13 indivíduos participaram de 10 encontros de educação em dor presencial (GP), e os outros 13 na modalidade online (GO). A avaliação da satisfação consistiu em 10 questões do MedRisk Instrument for Measuring Patient Satisfaction With Physical Therapy Care, e a avaliação da percepção foi obtida por meio de sete perguntas desenvolvidas pelos pesquisadores, específicas sobre o programa de educação em dor. Para análise estatística, foram utilizados os testes de Mann-Whitney e Qui-quadrado, software Biostat e nível de significância ≤0,05. RESULTADOS: Das 17 questões, houve diferença entre os grupos apenas em 5 questões. O GP relatou maior satisfação e percepção nas questões que se referem a “explicação sobre o tratamento recebido” (Qui2=6,19; p=0,05), “formas de evitar futuros problemas” (Qui2=4,727; p=0,03), “retorno para futuros serviços” (Qui2=4,727; p=0,03), “relacionamento com outras pessoas” (10 vs 8; p=0,03) e “aumento do nível de atividade física” (9 vs 8; p=0,03). CONCLUSÃO: Indivíduos com dor musculoesquelética crônica mostraram boa satisfação e percepção de um programa de educação em neurociência da dor tanto na modalidade online quanto na presencial. Algumas diferenças foram observadas entre ambas, sobretudo nas questões que parecem envolver contato face-a-face com um profissional, com resultados mais positivos quando o programa é oferecido de forma presencial.

ABSTRACT BACKGROUND AND OBJECTIVES: The complexity of chronic musculoskeletal pain requires the need to know the treatment strategies from the perspective of the service user. The objective of this study was to analyze the satisfaction and perception of individuals with chronic musculoskeletal pain participating in a pain neuroscience education program in the online and face-to-face modalities. METHODS: This is a cross-sectional observational study, composed of 26 participants, of which 13 individuals participated in 10 meetings of face-to-face pain education (FG), and the other 13 in the online modality (OG). The satisfaction assessment consisted of 10 questions from the MedRisk Instrument for Measuring Patient Satisfaction With Physical Therapy Care, and the perception assessment was obtained by means of seven questions developed by the researchers, specific about the pain education program. For statistical analysis, Mann-Whitnney and chi square tests, Biostat software and significance level (0.05) were used. RESULTS: Of the 17 questions, there was a difference between the groups in only 5 questions. The FG reported greater satisfaction and perception in the questions of “explanation about the treatment received” (Chi2=6.19; p=0.05), “ways to avoid future problems” (Chi2=4.727; p=0.03), “return to future services” (Chi2=4.727; p=0.03), “relationship with other people” (10 vs 8; p=0.03) and “increased level of physical activity” (9 vs 8; p=0.03). CONCLUSION: There was good satisfaction and perception of individuals with chronic musculoskeletal pain participating in a pain neuroscience education program both in the online and face-to-face modality. Some differences were observed between both, especially in issues that seem to involve face-to-face contact with a professional, with more positive results in the FG.

Abstract Objective Investigate the auditory function of the elderly using the middle latency potentials. Methodology Group 1 (G1): 20 healthy individuals of both genders, older than 60 years, without hearing loss. Group 2 (G2): 20 healthy individuals of both sexes, older than 60 years, with hearing loss in frequencies from 4 to 8 kHz. Potential recording was performed with unilateral and bilateral stimulation and the Binaural Interaction Component was calculated. Results Na latency in C3A1 was greater in the stimulation of the right ear in G2 and the amplitude of Na-Pa was greater in the stimulation of the right ear and recording in C3A1 in G1. The latency of the Pa component was higher in the stimulation of the right ear recorded in C4A2. The Pb component in G2 by bilateral stimulation and recorded in C4A2 had higher latency. The first and second negative and positive peaks presented greater amplitude in G1. In C3A1, the 1st negative peak was more negative in G1 and the 2nd positive peak showed greater amplitude in C4A2 in both groups. Conclusion The transmission of auditory information to the primary auditory cortex is impaired with aging, especially in unilateral stimulation, reinforced by losses in elderly people with peripheral hearing loss, such as in the binaural interaction at the cortical and subcortical levels. Thus, the AMLR has shown to be a sensitive examination to investigate neuroauditory disorders in the elderly, especially related to high-frequency hearing loss and primary auditory cortex dysfunctions caused by the aging process. potentials G (G1) genders 6 years (G2) sexes kHz calculated CA C A C3A NaPa C4A st nd groups levels Thus highfrequency high frequency process (G1 (G2 (G

Abstract Trauma is a leading cause of death, permanent disability, and health care cost worldwide. The young and economically active are the most affected population. Exsanguination due to noncompressible torso hemorrhage is one of the most frequent causes of early death, posing a significant challenge to trauma and vascular surgeons. The possibility of limb loss due to vascular injuries must also be considered. In recent decades, the approach to vascular injuries has been significantly modified. Angiotomography has become the standard method for diagnosis, endovascular techniques are currently incorporated in treatment, and damage control, such as temporary shunts, is now the preferred approach for the patients sustaining physiological derangement. Despite the importance of this topic, few papers in the Brazilian literature have offered guidelines on vascular trauma. The Brazilian Society of Angiology and Vascular Surgery has developed Projetos Diretrizes (Guideline Projects), which includes this publication on vascular trauma. Since treating trauma patients is a multidisciplinary effort, the Brazilian Trauma Society (SBAIT) was invited to participate in this project. Members of both societies reviewed the literature on vascular trauma management and together wrote these guidelines on vascular injuries of neck, thorax, abdomen, and extremities. death disability worldwide population surgeons considered decades modified diagnosis treatment control shunts derangement topic Guideline Projects, Projects , Projects) effort SBAIT (SBAIT project neck thorax abdomen extremities

Resumo Trauma é uma causa importante de morbimortalidade, que acomete principalmente jovens. A hemorragia incoercível é o principal mecanismo de óbito precoce nessas vítimas, e as lesões vasculares não compressíveis representam grandes desafios para os cirurgiões. O traumatismo vascular impacta diretamente a viabilidade de membros traumatizados, aumentando o risco de amputação. Nas últimas décadas, muitas condutas de diagnóstico e tratamento de lesões vasculares traumáticas foram modificadas. A angiotomografia suplantou a angiografia como padrão ouro para diagnóstico, as técnicas endovasculares foram incorporadas ao arsenal terapêutico e o conceito de “controle de danos” foi estabelecido. No entanto, há lacunas na literatura nacional sobre a normatização de condutas em trauma vascular, principalmente considerando as limitações do Brasil. Por isso, a Sociedade Brasileira de Angiologia e de Cirurgia Vascular e a Sociedade Brasileira de Atendimento Integrado ao Traumatizado revisaram a literatura disponível sobre trauma vascular e organizaram diretrizes sobre o diagnóstico e tratamento dessas lesões. morbimortalidade jovens vítimas cirurgiões traumatizados amputação décadas modificadas controle danos estabelecido entanto Brasil isso

Resumo: Introdução: A mobilidade é uma ação básica praticada durante a execução dos cuidados gerais de enfermagem durante a hospitalização. Contudo, quando se trata de pessoas idosas, essa ação geralmente é polemizada por se constituir um risco para quedas. Objetivo: Apreender a estrutura da representação social da equipe de enfermagem acerca da mobilidade para pessoa idosa hospitalizada. Método: Pesquisa descritiva-exploratória de abordagem qualitativa, fundamentada na Teoria das Representações Sociais, com foco na abordagem estrutural. O grupo social estudado foi composto por 100 profissionais da equipe de enfermagem atuantes em unidades destinadas ao cuidado de pessoas idosas, em um hospital universitário, na cidade de Salvador, Bahia, Brasil. A coleta dos dados ocorreu em dois momentos, através da associação livre de palavras e entrevista não- estruturada. Os dados da associação livre de palavras foram processados pelo software EVOC que determinou a estrutura da representação social através do quadro de quatro casas. Para as entrevistas utilizou-se a análise de conteúdo. A discussão envolveu todo o corpus da pesquisa. Resultados: No quadro, considerando a frequência e a ordem média das evocações, os termos “Queda, Acamado e Cuidado” compuseram o núcleo central. Da análise das entrevistas, surgiram três categorias temáticas: cuidados de mobilidade envolvendo os riscos, cuidados de mobilidade, voltados para manter a independência/autonomia e cuidado para lidar com as barreiras à mobilidade. Para a equipe de enfermagem investigada a representação social da mobilidade está associada a deambulação, com movimentos limitados diante dos riscos de queda que interfere na autonomia e independência. Conclusão: A estrutura das Representações Sociais sobre a mobilidade da pessoa idosa hospitalizada está ancorada em situações do cotidiano da prática profissional do grupo investigado, evidenciando conflitos entre promover prevenção/recuperação da incapacidade pela hospitalização e evitar outros danos à saúde pelo risco de quedas.

Abstract: Introduction: Mobility is a basic action practiced during the execution of general nursing care during hospitalization, however, when it comes to elderly people, this action is usually controversial because it constitutes a risk for falls. Objective: To apprehend the structure of the social representations of the nursing team regarding the mobility of the hospitalized elderly person. Methods: This is exploratory descriptive research with a qualitative approach, based on the principles of the Theory of Social Representations, with a focus on the structural approach. The social group studied was composed of 100 professionals from the nursing team who work in units dedicated to the care of the elderly at a university hospital in the city of Salvador, Bahia, Brazil. Data collection took place in two moments, through the free word association and unstructured interview techniques. The free word association data were processed by the EVOC software, which determined the structure of the social representation through the four-place table. Content analysis was used for the interviews. The discussion involved the entire research corpus. Results: In the table, considering the frequency and the average order of evocations, the terms “fall, bedridden and care” composed the central nucleus. From the analyses of interviews, three thematic categories emerged: Mobility care involving risks, mobility care, aimed at maintaining independence/autonomy and care to deal with barriers to mobility. For the nursing team investigated, the social representation of mobility is associated with ambulation, with limited movements in the face of the risk of falling, which stimulates autonomy and independence. Conclusion: The structure of the Social Representations on the mobility of the hospitalized elderly person is anchored in everyday situations of the professional practice of the investigated group, evidencing conflicts between promoting prevention/recovery of incapacity through hospitalization and avoiding other health damages due to the risk of falls.

Resumo Objetivo Definir o perfil epidemiológico e as comorbidades associadas dos pacientes submetidos à artroplastia total do joelho (ATJ) em dois hospitais de referência. Métodos Durante o estudo observacional transversal, foram avaliados 294 pacientes submetidos à ATJ em 2 hospitais de atenção terciária. Coletou-se, por entrevista direta, o diagnóstico das comorbidades auto-relatadas. Foram calculados o índice de comorbidades funcionais (do inglês Functional Comorbidity Index, FCI) e o índice modificado de cinco fatores de fragilidade (do inglês 5-Factor Modified Frailty Index, mFI-5). Avaliou-se a incidência das comorbidades e a relação destas com os índices calculados. Resultados A maioria dos pacientes da amostra foram mulheres (p¼ 0,000) entre a sétima e oitava décadas de vida. A hipertensão arterial sistêmica foi a patologia mais comum, seguida de obesidade e diabetes mellitus. O ICFapresentou uma relação direta com sexo feminino (p¼ 0,038) e a obesidade (p< 0,001). O mFI-5 apresentou relação somente com a obesidade (p¼ 0,022), e demonstrou uma chance maior de complicações nesse grupo. Conclusão Os pacientes submetidos à ATJ são essencialmente portadores de comorbidades clínicas que podem influenciar negativamente os resultados funcionais e comprometer a segurança do procedimento. A identificação dos fatores de risco pode contribuir para a segurança e melhor seleção dos candidatos a ATJ.

Abstract Objective To define the epidemiological profile and the associated comorbidities of patients submitted to total knee arthroplasty (TKA) in two reference hospitals. Methods During the present cross-sectional observational study, 294 patients submitted to TKA were evaluated in 2 tertiary care hospitals. The diagnosis of selfreported comorbidities was collected by direct interview. The Functional Comorbidity Index (FCI) and the 5-Factor Modified Frailty Index (mFI-5) were calculated. The incidence of comorbidities and their relationship with the calculated indexes were evaluated. Results Most of the patients in the sample were women (p¼ 0.000) between the seventh and eighth decades of life. Systemic arterial hypertension was the most common pathology, followed by obesity and diabetes mellitus. The FCI presented a direct relationship with females (p¼ 0.038) and obesity (p< 0.001). The mFI-5 was only associated to obesity (p¼ 0.022), demonstrating a higher chance of complications in this group. Conclusion Patients undergoing TKA are essentially carriers of clinical comorbidities that can negatively influence functional results and compromise the safety of the procedure. The identification of risk factors can contribute to the safety and better selection of TKA candidates.

Abstract Patients with lepromatous or borderline leprosy may present two types of vasculonecrotic reactions: Lucio’s phenomenon (LP) and necrotic erythema nodosum leprosum (nENL). These are serious conditions, which mostly lead to life-threatening infectious and thrombotic complications. The authors report the case of a patient with leprosy recurrence associated with an atypical type II reaction with LP characteristics on histopathology.

Abstract Microbialites are the most abundant life evidence in Precambrian sedimentary rocks. They are produced by microbial interaction activity and sedimentary processes reflecting paleoenvironmental conditions. The Ediacaran-Cambrian carbonate and siliciclastic successions in the Southern Amazon Craton in Central Brazil, provide a key opportunity to understand how the metazoan life coexisted with the microbial communities. The spatial and temporal distribution of microbialites as well as morphological and paleoenvironmental changes have been assessed, reinterpreting previous works and including new data from the Araras-Alto Paraguai and Corumbá basins. The deposition was controlled by subsidence and sea-level changes that affected these basins, considered extensions of epicontinental seas during the Gondwana assembly. The stromatolites are restricted to coastal deposits and experienced thriving flourishment intervals after the Marinoan Glaciation (635 Ma). Post-glacial transgression was marked by microbial colonization in shallow platforms represented by stratiform and giant domical stromatolites in the Araras-Alto Paraguai Basin. The continuity of the transgression generated a moderately deep aragonite sea at about 622 Ma. A progressive sea-level fall caused the implantation of coastal environments under greenhouse conditions with tidal flat and sabkha settings colonized by centimetric-scale stromatolites. The sea retreat was accompanied by progressive uplift, causing a moderate inversion of the basin and erosion of the succession until ~560 Ma with the deposition of the last preserved tidal flat deposits with the occurrence of thrombolites. The subsiding Corumbá Basin was the site of microbially-induced deposition of carbonates in a shallow platform connected to an offshore setting with the proliferation of metazoan straddling the Ediacaran-Cambrian boundary. Microbial communities were restricted to lagoon deposits during the Lower Cambrian transgression in the Araras-Alto Paraguai Basin and the last phase refers to the sea retreat towards southeast, developing a fluvial system connected with the arid and evaporitic tidal flats colonized by microbialites that lasted until the upper Cambrian. Except for the post-glacial stromatolites, the columnar and domal microbialite indicate that the coastal settings dominated the Ediacaran-Cambrian transition. The preservation of microbialites in the post-glacial intervals can be associated with the Mg-Ca-CO3 oversaturation in dolomitic platforms. The rapid calcification and ability to resist the dissolution and replacement have increased the stromatolites’ preservation potential reported here, where its well-preserved occurrence in tidal flats and sabkha occurs due to intense early diagenetic silicification. The change from carbonate accumulation to siliciclastic-rich environments contributed to the demise of microbially-induced strata. In general, the scarce coexistence between coastal stromatolite and metazoan-bearing marine deposits makes it challenging to establish a competitive relationship between these organisms, as previously postulated.

Abstract Agribusiness is the most prominent sector in the Brazilian economy, contributing over the last few years with about 30% of the Gross Domestic Product (GDP) and being responsible for more than 40% of the products exported by the country. During this period, several economic development programs in Brazil were created by the federal government, contemplating the agricultural sector to increase productivity in the field, with actions and intensification of the use of fertilizers, pesticides, creation of agricultural research institutes, training of agronomists, and veterinarians, in addition to facilitating access to credit for rural producers. In this sense, the biotechnology sector great significant greatly influenced the expansion of agricultural production, increasing field efficiency and agricultural production productivity. The objective of this work was to analyze the number of patents in the agribusiness sector to technological development in the biotechnology sector between 1978 and 2018, with data from the Brazilian National Institute of Industrial Property (INPI). There is a growing number of patents over the period, as well as an increase in the number of undergraduate and graduate courses in the field of biotechnology in the country since the sector is considered strategic as a source of innovation in science and technology, supporting the country's development, structuring itself to sustain economic growth, with research, science, technology, and innovation.

Resumo Avaliar o Estado Nutricional (EN) permite rastrear desnutrição e obesidade, condições associadas a doenças crônicas não transmissíveis. O índice de massa gorda (IMG) destaca-se em relação aos indicadores tradicionais de EN. No entanto, propostas que definem limiares para IMG não são sensíveis para discriminar casos extremos (graus de obesidade ou magreza). Apenas uma proposta (NHANES) estabeleceu oito categorias de classificação EN (IMG), mas foi determinada por densitometria corporal total (DXA). Porém, DXA é caro e nem sempre disponível. O objetivo foi testar a validade do método NHANES usando bioimpedância elétrica (BIA) e dobras cutâneas (DOCs) para classificar o EN. O IMG de 135 (69 mulheres) universitários com idade entre 18 e 30 anos foi obtido por DXA, BIA e DOCs. A concordância foi testada entre os instrumentos (Bland-Altman) e classificações de EN (Qui quadrado e índice Kappa). O teste de concordância com a DXA indicou as DOCs subestimarem o IMG (-1,9 kg/m2) para ambos os sexos e a BIA em mulheres (-2,0 kg/m2). No entanto, as BIA superestimaram o IMG (1,4 kg/m2) nos homens, embora com menos viés. Não houve concordância entre as classificações de EN (NHANES) pelo IMG entre DXA e BIA/DOCs. A exceção ocorreu entre DXA e BIA em homens que apresentaram concordância “razoável” (k = 0,214; p = 0,001). Em conclusão, DOCs e BIA não mostraram concordância suficiente para substituir DXA pela classificação de EN, dentro dos limites NHANES. As ferramentas diferem para medir IMG e classificar categorias de EN (NHANES).

Abstract Assessment of the Nutritional Status (NS) allows screening for malnutrition and obesity, conditions associated with chronic non-communicable diseases. The fat mass index (FMI) stands out concerning traditional NS indicators. However, proposals that define thresholds for FMI are not sensitive to discriminate extreme cases (degrees of obesity or thinness). Only one proposal (NHANES), determined by total body densitometry (DXA), established eight categories of NS classification (FMI). However, DXA is expensive and not always clinically available. Our study aims to test the validity of the NHANES method using electrical bioimpedance (BIA) and skinfold thickness (ST) to classify NS. The FMI of 135 (69 women) university students aged 18 to 30 years old was determined using DXA, BIA, and ST. The agreement between the instruments (Bland-Altman) and the agreement coefficient in the NS classifications (Chi-square and Kappa index) were tested. The agreement test against DXA indicated that ST underestimated the FMI (-1.9 kg/m2) for both sexes and BIA in women (-2.0 kg/m2). However, BIA overestimated FMI (1.4 kg/m2) in men, although with less bias. There was no agreement between the NS classifications (NHANES) by FMI between DXA and BIA, or DXA and ST. The exception occurred between DXA and BIA in men who showed a slightly better consensus, considered “fair” (k = 0.214; p = 0.001). In conclusion, ST and BIA did not show enough agreement to replace DXA for NS classification, within NHANES thresholds. The FMI measurement tools for the NHANES classification of the categories of NS matters.

RESUMO Objetivo: As fraturas toracolombares do tipo explosão, embora amplamente descritas na literatura, permanecem sem consenso quanto às modalidades de tratamento. O objetivo do presente estudo foi avaliar os resultados clínicos e radiológicos da instrumentação percutânea sem artrodese como método de fixação dessas lesões. Métodos: O estudo transversal retrospectivo avaliou 16 pacientes por meio da aferição da cifose regional pelo método de Cobb e dos escores de qualidade de vida e retorno ao trabalho (Índice de Incapacidade de Oswestry, EVA, SF-36 e Denis). Resultados: Seis meses depois do tratamento cirúrgico, verificou-se 62,5% dos pacientes com incapacidade mínima segundo o Índice de Incapacidade Oswestry, manutenção da correção da cifose regional e ausência de falha da síntese. Conclusões: Os desfechos clínicos e radiológicos do estudo sugerem que a fixação minimamente invasiva é relevante para o tratamento das fraturas toracolombares do tipo explosão. Nível de evidência IV; Estudo observacional: coorte retrospectiva.

ABSTRACT Objective: There is still no consensus as to the treatment options for thoracolumbar burst fractures, although these fractures are widely described in the literature. The aim of this study was to evaluate the clinical and radiological outcomes of percutaneous instrumentation without arthrodesis as a method of fixation of these lesions. Methods: This retrospective, cross-sectional study evaluated 16 patients by measuring regional kyphosis using the Cobb method and the scores for quality of life and return to work (Oswestry Disability Index, VAS, SF-36 and Denis). Results: Six months after surgical treatment, 62.5% of all patients showed minimal disability according to the Oswestry Disability Index, maintenance of regional kyphosis correction and no synthesis failure. Conclusions: The clinical and radiological outcomes of the study suggest that minimally invasive fixation is indicated for the treatment of thoracolumbar burst fractures. Level of evidence IV; Observational study: retrospective cohort.

RESUMEN Objetivo: Las fracturas toracolumbares del tipo explosión, aunque están ampliamente descritas en la literatura, siguen sin tener consenso en cuanto a las modalidades de tratamiento.. El obetivo del presente estudio fue evaluar los resultados clínicos y radiológicos de la instrumentación percutánea sin artrodesis como método de fijación de estas lesiones. Métodos: El estudio transversal retrospectivo evaluó a 16 pacientes, midiendo la cifosis regional mediante el método de Cobb y las puntuaciones de calidad de vida y reincorporación al trabajo (Índice de Discapacidad de Oswestry, VAS, SF-36 y Denis). Resultados: Seis meses después del tratamiento quirúrgico, el 62,5% de los pacientes presentaron discapacidad mínima según el Índice de Discapacidad de Oswestry, mantenimiento de corrección de cifosis regional y ausencia de fallo de síntesis. Conclusiones: Los resultados clínicos y radiológicos del estudio sugieren que la fijación mínimamente invasiva es pertinente para el tratamiento de fracturas toracolumbares del tipo explosión. Nivel de evidencia IV; Estudio observacional: estudio de cohorte retrospectivo.

ABSTRACT. This study aimed to assess the nutrient intake and milk production of dairy goats fed with total mixed rations with different species of forage cacti. Five pluriparous Saanen goats (50 ± 4 kg) at nine weeks of lactation were allocated in a Latin square (5 x 5) with five diets and five periods. Each period was composed of 10 days for adaptation and seven days for collection. The treatments were composed of 473.0 to 501.0 g kg-1 of forage cacti: xiquexique (Pilosocereus gounellei), mandacaru (Cereus jamacaru), facheiro (Pilosocereus chrysostele), cactus cladodes cv. miúda (Nopalea cochenillifera Salm-Dyck) and cactus cladodes cv. orelha de elefante mexicana (Opuntia stricta); plus sabiá hay (Mimosa caesalpiniifolia) (188.0 to 198.0 g kg-1) and concentrate (311.0 to 329.0 g kg-1). The intake of dry matter, organic matter, ether extract, neutral detergent fiber, total carbohydrates, and water intake through diet components were unaffected by experimental diets. For milk production and feed efficiency, no difference was observed among the diets. All diets containing different species of forage cacti can be used for dairy goats feed.

Abstract This reports a case of scorpionism caused by Tityus serrulatus. A male adult was stung while unloading bananas at the supply center in Belém, Pará, Brazil. The bananas originated in another state (Bahia) and were brought to Belém by truck. The patient presented with pain, edema, and erythema at the sting site, and was classified as low-risk. The specimen was identified as T. serrulatus and symptomatic treatment and clinical observation were advised. The patient was discharged later without further complications. This is the first known envenomation caused by T. serrulatus, a non-native species to Pará, in the Brazilian Amazon.