Este trabalho relata um caso de feohifomicose subcutânea causado por Exophiala jeanselmei em um paciente que havia recebido transplante de coração e mantinha terapia com micofenolato mofetil, tracolimus e prednisone. As lesões tiveram início após trauma na perna inferior direita que evoluíram produzindo múltiplos nódulos e úlceras. Diagnóstico foi realizado através de avaliação histológica e de características macroscópicas e microscópicas da cultura das lesões da pele. O paciente fez uso de itraconazol em concentração de 200 mg/dia durante três meses, não se observando no entanto, melhora das lesões. Após este período, o paciente foi tratado com anfotericina B a uma concentração de 0,5 mg/Kg/dia totalizando 3,8 g. Após quatro meses de tratamento as lesões mostraram melhora evidente, verificando-se fechamento das fístulas e cicatrização das lesões.

We report a case of phaeohyphomycosis caused by Exophiala jeanselmei in a cardiac transplant recipient maintained on immunosuppressive therapy with mycophenolate mofetil tacrolimus and prednisone. The lesion began after trauma on the right leg that evolved to multiple lesions with nodules and ulcers. Diagnosis was performed by histological examination and culture of pus from skin lesions. Treatment consisted of itraconazole (200 mg/day) for three months with no improvement and subsequently with amphotericin B (0.5 mg/Kg per day to a total of 3.8 g intravenously). After four months of treatment, the lesions showed marked improvement with reduction in the swelling and healing of sinuses and residual scaring.

A transitory increase in blood pressure (BP) is observed following upper airway surgery for obstructive sleep apnea syndrome but the mechanisms implicated are not yet well understood. The objective of the present study was to evaluate changes in BP and heart rate (HR) and putative factors after uvulopalatopharyngoplasty and septoplasty in normotensive snorers. Patients (N = 10) were instrumented for 24-h ambulatory BP monitoring, nocturnal respiratory monitoring and urinary catecholamine level evaluation one day before surgery and on the day of surgery. The influence of postsurgery pain was prevented by analgesic therapy as confirmed using a visual analog scale of pain. Compared with preoperative values, there was a significant (P < 0.05) increase in nighttime but not daytime systolic BP (119 ± 5 vs 107 ± 3 mmHg), diastolic BP (72 ± 4 vs 67 ± 2 mmHg), HR (67 ± 4 vs 57 ± 2 bpm), respiratory disturbance index (RDI) characterized by apnea-hypopnea (30 ± 10 vs 13 ± 4 events/h of sleep) and norepinephrine levels (22.0 ± 4.7 vs 11.0 ± 1.3 µg l-1 12 h-1) after surgery. A positive correlation was found between individual variations of BP and individual variations of RDI (r = 0.81, P < 0.01) but not between BP or RDI and catecholamines. The visual analog scale of pain showed similar stress levels on the day before and after surgery (6.0 ± 0.8 vs 5.0 ± 0.9 cm, respectively). These data strongly suggest that the cardiovascular changes observed in patients who underwent uvulopalatopharyngoplasty and septoplasty were due to the increased postoperative RDI.

Hemoglobinopathies have been considered the most frequent hereditary disease in Brazilian population, constituting a Public Health problem. This paper reports on screening in workers at FIOCRUZ-RJ., exposed to some hazards factors such as, chemical substances, radiation, excessive cold and heat etc., with the objective of evaluating the impact of these factors in carriers of hemoglobinopathies, mainly in sickle cell trait (AS).

Após ligeiras considerações a propósito das manifestações neurológicas da periarterite nodosa, são relatados três casos com comprometimento do sistema nervoso periférico. É salientada a maior freqüência de comprometimento do sistema nervoso periférico. Entre as síndromes neurológicas periféricas é ressaltada a maior freqüência das mononeuropatias múltiplas com o relato de dois casos (casos 1 e 3). O caso 2 é caracterizado pelo comprometimento polirradicular (polirradiculoneurite). Finalmente, o caso 3 é caracterizado pela associação de mononeuropatias múltiplas com uma síndrome do forâme rasgado posterior. O diagnóstico da periarterite nodosa, em todos os casos, foi confirmado pelo exame histopatológico.

After brief considerations about neurologic manifestations in periarteritis nodosa, three cases with involvement of peripheral nerves are reported. Between the peripheral nerves syndromes the multiple peripheral neuritis (mononeuritis multiplex) is stressed and two cases are studied (cases 1 and 3). Case 2 was characterized by polyradicular involvement (polyradiculo-neuritis). Case 3 was characterized by the association of multiple peripheral neuritis with jugular foramen syndrome; there is not an alike case related in the medical literature. The correct diagnosis, in all cases, was made through histological examination. Necroscopic findings are reported in two eases. Clinical features are discussed.

São apresentados os resultados das investigações sobre os focos de esquistossomose nas localidades de Pedro de Toledo e Itariri, com referência especial aos índices de infecção natural obtidos para a espécie Biomphalaria tenagophila. Êste molusco, transmissor de esquistossomose no Vale do Ribeira já foi assinalado nos seguintes municípios daquela região: Eldorado, Iguape, Itariri, Jacupiranga, Juquiá, Miracatu, Pariqueraçu, Pedro de Toledo, Registro e Sete Barras. Os índices cercáricos de 68,1%, 75,0% e 81,3% obtidos em alguns lotes de B. tenagophila, os mais altos já verificados para esta espécie, vem mais uma vez comprovar sua grande suscetibilidade à infecção pelo Schistosoma mansoni.

The results of the studies about foci of Schistosomiasis in the localities of Pedro de Toledo and Itariri, are presented with special reference to the natural infection rate, reached for the Biomphalaria tenagophila species. This snails which transmits Schistosomiasis in "Vale do Ribeira", was also found in the following counties in that region of the State of São Paulo: Eldorado, Iguape, Itariri, Jacupiranga, Juquiá, Miracatu, Pariqueraçu, Pedro de Toledo, Registro and Sete Barras. The natural infection rates of 68.1%; 75.0%; and 81.3% obtained in some samples of B. tenagophila, the highest till now verified of this species, prove once more the great susceptibility to the infection by Schistosoma mansoni.

São apresentados os resultados das investigações sobre os focos de esquistossomose nas localidades de Pedro de Toledo e Itariri, com referência especial aos índices de infecção natural obtidos para a espécie Biomphalaria tenagophila. Êste molusco, transmissor de esquistossomose no Vale do Ribeira já foi assinalado nos seguintes municípios daquela região: Eldorado, Iguape, Itariri, Jacupiranga, Juquiá, Miracatu, Pariqueraçu, Pedro de Toledo, Registro e Sete Barras. Os índices cercáricos de 68,1%, 75,0% e 81,3% obtidos em alguns lotes de B. tenagophila, os mais altos já verificados para esta espécie, vem mais uma vez comprovar sua grande suscetibilidade à infecção pelo Schistosoma mansoni.

The results of the studies about foci of Schistosomiasis in the localities of Pedro de Toledo and Itariri, are presented with special reference to the natural infection rate, reached for the Biomphalaria tenagophila species. This snails which transmits Schistosomiasis in "Vale do Ribeira", was also found in the following counties in that region of the State of São Paulo: Eldorado, Iguape, Itariri, Jacupiranga, Juquiá, Miracatu, Pariqueraçu, Pedro de Toledo, Registro and Sete Barras. The natural infection rates of 68.1%; 75.0%; and 81.3% obtained in some samples of B. tenagophila, the highest till now verified of this species, prove once more the great susceptibility to the infection by Schistosoma mansoni.