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ABSTRACT Hematopoietic stem cell transplant (HSCT) recipients are at -increased risk for severe COVID-19. The aim of this study was to evaluate the burden of COVID-19 in a cohort of HSCT recipients. This retrospective study evaluated a cohort of adult hospitalized HSCT recipients diagnosed with COVID-19 in two large hospitals in São Paulo, Brazil post-HSCT, from January 2020 to June 2022. The primary outcome was all-cause mortality. Of 49 cases, 63.2% were male with a median age of 47 years. Allogeneic-HSCT (51.2%) and autologous-HSCT (48.9%) patients were included. The median time from HSCT to COVID-19 diagnosis was 398 days (IQR: 1211-134), with 22 (44.8%) cases occurring within 12 months of transplantation. Most cases occurred during the first year of the pandemic, in non-vaccinated patients (n=35; 71.4%). Most patients developed severe (24.4%) or critical (40.8%) disease; 67.3% received some medication for COVID-19, primarily corticosteroids (53.0%). The probable invasive aspergillosis prevalence was 10.2%. All-cause mortality was 40.8%, 51.4% in non-vaccinated patients and 14.2% in patients who received at least one dose of the vaccine. In the multiple regression analyses, the variables mechanical ventilation (OR: 101.01; 95% CI: 8.205 – 1,242.93; p = 0.003) and chest CT involvement at diagnosis ≥50% (OR: 26.61; 95% CI: 1.06 – 664.26; p = 0.04) remained associated with all-cause mortality. Thus, HSCT recipients with COVID-19 experienced high mortality, highlighting the need for full vaccination and infection prevention measures. (HSCT increased COVID19. COVID19 COVID 19. 19 COVID-1 Paulo postHSCT, postHSCT post HSCT, post-HSCT 202 2022 allcause all cause 4 632 63 2 63.2 years AllogeneicHSCT Allogeneic 51.2% 512 51 (51.2% autologousHSCT autologous 48.9% 489 48 9 (48.9% included 39 IQR (IQR 1211134, 1211134 1211 134 , 1211-134) 44.8% 448 44 8 (44.8% 1 transplantation pandemic nonvaccinated non vaccinated n=35 n35 n 35 (n=35 71.4%. 714 71.4% . 71 71.4%) 24.4% 244 24 (24.4% 40.8% 408 40 (40.8% disease 673 67 3 67.3 COVID19, 19, 53.0%. 530 53.0% 53 0 (53.0%) 102 10 10.2% Allcause All 514 51.4 142 14 14.2 vaccine analyses OR (OR 101.01 10101 101 01 95 CI 8205 205 8.20 1,242.93 124293 242 93 0.003 0003 003 50 ≥50 26.61 2661 26 61 106 06 1.0 664.26 66426 664 0.04 004 04 Thus measures COVID1 COVID- 20 6 63. 51.2 5 (51.2 48.9 (48.9 121113 121 13 1211-134 44.8 (44.8 n=3 n3 (n=3 71.4 7 24.4 (24.4 40.8 (40.8 67. 53.0 (53.0% 10.2 51. 14. 101.0 1010 820 8.2 1,242.9 12429 0.00 000 00 ≥5 26.6 266 1. 664.2 6642 66 0.0 (51. 48. (48. 12111 1211-13 44. (44. n= (n= 71. 24. (24. 40. (40. 53. (53.0 10. 101. 82 8. 1,242. 1242 ≥ 26. 664. 0. (51 (48 1211-1 (44 (n (24 (40 (53. 1,242 124 (5 (4 1211- (2 (53 1,24 ( 1,2 1,

https://doi.org/10.1590/s1678-9946202466017

Cardiopulmonary radiographic changes in dogs naturally infected with Dirofilaria immitis
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Ferreira, Alexandre M.

; Netto, Carlos Eduardo C.

; Santos-Sousa, Carlos Augusto

; Souza Júnior, Paulo

; Bagetti Filho, Hélio José S.

; Abidu-Figueiredo, Marcelo

Pesquisa Veterinária Brasileira

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2024, Volume 44 elocation e07466

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT: Heartworm disease is a zoonosis caused by Dirofilaria immitis, a nematode parasite of worldwide distribution and considered one of the most virulent of dogs, which are definitive and infected hosts during the blood meal of vector mosquitoes (Aedes sp., Anopheles sp. and Culex sp.). The disease has a worldwide prevalence, with a higher incidence in tropical and subtropical climate areas, and affects animals of any breed, sex, and age group. Most animals are asymptomatic, but the disease can cause various cardiovascular and respiratory symptoms. The pathophysiology is related to vessel obstruction and an intense inflammatory reaction in the lung parenchyma, with cardiovascular and respiratory symptoms leading to signs that can be severe and lead to the death of the host. It can be diagnosed through blood tests, and chest X-rays are used to assess the severity of clinical signs and help establish a prognosis. Cardiovascular alterations appear as an increase in vascular caliber, an increase in the right heart silhouette, and pulmonary patterns compatible with infection. This study aimed to describe the conditional radiographic changes caused by the parasite in the lungs, intrathoracic vessels and heart in 30 dogs, independent of breed and sex, with an average age of 9.9 years and an average weight of 10.25kg, originating from routine care at a veterinary hospital in the city of Rio de Janeiro, from January 2022 to December 2022. All animals were diagnosed with a positive heartworm infection and cardiorespiratory symptoms as essential conditions for participation in the study. The animals were x-rayed and had their lung patterns evaluated, in addition to measuring their vascular caliber and cardiac indices using vertebral-heart size (VHS), manubrium-heart size (MHS) and sphericity index (CSI). Most animals presented pulmonary patterns such as bronchoalveolar and bronchial and increased VHS and MHS indices. Increased and borderline values of CSI measurements were found in half of the patients, demonstrating that the parasite can trigger significant radiographic changes or present potential further worsening. ABSTRACT immitis dogs Aedes sp sp.. . sp.) prevalence areas sex group asymptomatic parenchyma host tests Xrays X rays prognosis silhouette lungs 3 99 9 9. 1025kg kg 10 25kg 10.25kg Janeiro 202 xrayed x rayed evaluated vertebralheart vertebral VHS, , (VHS) manubriumheart manubrium (MHS CSI. (CSI) patients worsening 1 20 (VHS (CSI 2

RESUMO: A dirofilariose é uma zoonose causada pela Dirofilaria immitis, parasita nematoide de distribuição mundial e considerado um dos mais patogênicos de cães, que são hospedeiros definitivos e infectados durante o repasto sanguíneo de mosquitos vetores (Aedes sp., Anopheles sp. e Culex sp.). A doença apresenta prevalência mundial, com maior incidência em áreas de clima tropical e subtropical, acometendo animais de qualquer raça, sexo e faixa etária. A maioria dos animais é assintomática, entretanto, a doença pode causar diversos sintomas cardiovasculares e respiratórios. A fisiopatologia se relaciona com a obstrução de vasos e com intensa reação inflamatória no tecido pulmonar, com sintomatologia cardiovascular e respiratória, levando a sinais que podem ser graves e levar ao óbito do hospedeiro. Pode ser diagnosticada através de exames de sangue e as radiografias de tórax são utilizadas para avaliar a gravidade dos sinais clínicos e auxiliar no estabelecimento do prognóstico. Alterações cardiovasculares surgem como aumento de calibre vascular, aumento de silhueta cardíaca direita e padrões pulmonares compatíveis com infecção. No presente artigo objetivou-se descrever as alterações radiográficas estabelecidas pelo parasita nos pulmões, nos vasos intratorácicos e no coração em 30 cães, independente de raça e sexo, com média de idade 9,9 anos e média de peso 10,25kg, oriundos da rotina de atendimento de um hospital veterinário na cidade do Rio de Janeiro, entre Janeiro de 2022 e Dezembro de 2022. Todos os animais possuem diagnóstico positivo para infecção por dirofilariose e sintomatologia cardiorrespiratória como condição indispensável para pertencerem ao estudo. Os animais foram radiografados e tiveram os padrões pulmonares avaliados, além da medição do calibre vascular e dos índices cardíacos através do VHS (índice cardio-vertebral), MHS (ou índice manúbrio-esternal) e CSI (índice de esfericidade). A maioria dos animais apresentou padrão pulmonar como broncoalveolar e bronquial e índices de VHS e MHS aumentados. Aumento e valores limítrofes das medidas de CSI foram encontrados em metade dos pacientes, demonstrando que o parasita pode desencadear alterações radiográficas significativas ou apresentar potencial agravamento posterior. RESUMO immitis cães Aedes sp sp.. . sp.) subtropical etária assintomática entretanto respiratórios respiratória hospedeiro prognóstico objetivouse objetivou pulmões 3 99 9 9, 1025kg kg 10 25kg 10,25kg 202 estudo avaliados cardiovertebral, cardiovertebral cardio vertebral , cardio-vertebral) manúbrioesternal manúbrio esternal manúbrio-esternal esfericidade. esfericidade esfericidade) aumentados pacientes posterior 1 20 cardio-vertebral 2

https://doi.org/10.1590/1678-5150-pvb-7466

Streptococcus equi subspecies zooepidemicus: an emergent cause of meningoencephalitis in Northeastern Brazil zooepidemicus
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Farias, Luis Arthur Brasil Gadelha

; Sousa, Marcos Maciel

; Cavalcante, Karene Ferreira

; Jucá, Marina Pinheiro Catunda

; Castro, Aldenise de Olinda

; Mello, Liana Perdigão

; Mesquita, Rafael Ferreira

; Bandeira, Silviane Praciano

; Marchi, Ana Paula

; Coelho, Tânia Mara Silva

; Lima Neto, Antônio Silva

; Arruda, Érico Antonio Gomes de

; Costa, Silvia Figueiredo

; Oliveira, Maura Salaroli de

; Perdigão Neto, Lauro Vieira

Revista do Instituto de Medicina Tropical de São Paulo

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2024, Volume 66 elocation e51

Resumo: En | Texto: En | PDF: En

ABSTRACT This study describes an outbreak of Streptococcus equi subspecies zooepidemicus infections that caused meningoencephalitis and bacteremia related to unpasteurized milk consumption in northeastern Brazil. Epidemiological investigations and a brief literature review were conducted. Strains with possible neurotropism had not been identified in Brazil before these cases; however, in 2023, another case of meningoencephalitis caused by Streptococcus equi sp. zooepidemicus was described, revealing the need to maintain surveillance and highlighting that these neurotropic strains continue to circulate in the environment. conducted cases however 2023 sp described environment 202 20 2

https://doi.org/10.1590/s1678-9946202466051

Measles, mumps and rubella vaccine 12 months after hematopoietic stem cell transplantation Measles 1
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Randi, Bruno Azevedo

; Fernandes, Eder Gatti

; Higashino, Hermes Ryoiti

; Lopes, Marta Heloisa

; Rocha, Vanderson Geraldo

; Costa, Silvia Figueiredo

; Sartori, Ana Marli Christovam

Revista do Instituto de Medicina Tropical de São Paulo

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2023, Volume 65 elocation e21

Resumo: En | Texto: En | PDF: En

ABSTRACT The measles, mumps and rubella (MMR) vaccine is usually recommended from 24 months after a hematopoietic stem cell transplant (HSCT). Some authors have demonstrated that the MMR vaccination can be safe from 12 months post-HSCT in non-immunosuppressed patients, as recommended by the Brazilian National Immunization Program/Ministry of Health, since 2006. The objectives of this study were to evaluate when patients received MMR vaccine after an HSCT in our care service and if there were reports of any side effects. We retrospectively reviewed the records of HSCT recipients who received at least one MMR dose in our care service, a quaternary teaching hospital in Sao Paulo city, Brazil, from 2017 to 2021. We identified 82 patients: 75.6% (90.1% in the autologous group and 45.1% in the allogeneic group) were vaccinated before 23 months post-transplantation. None reported side effects following the vaccination. Our data support that the MMR vaccination is safe from 12 to 23 months after HSCT. measles (MMR 2 . (HSCT) 1 postHSCT post nonimmunosuppressed non immunosuppressed ProgramMinistry Program Ministry Health 2006 city Brazil 201 2021 8 756 75 6 75.6 90.1% 901 90 (90.1 451 45 45.1 posttransplantation. posttransplantation transplantation. transplantation post-transplantation (HSCT 200 20 202 7 75. 90.1 9 (90. 4 45. 90. (90 (9 (

https://doi.org/10.1590/s1678-9946202365021

Prevalence of SARS-CoV-2 infection among health care workers in a reference hospital in Brazil SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- SARS-CoV
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Almeida, Vanessa Neves

; Cavalin, Roberta Figueiredo

; Gallo, Juliana Failde

; Guerra, Cleide Aparecida

; Madureira, Karen Cristina Rolim

; Rossi, Meire Bócoli

; Sobreira, Rozania Soeli dos Santos

; Santos, Ana Paula

; Luna, Expedito

; Lindoso, José Angelo Lauletta

Revista do Instituto de Medicina Tropical de São Paulo

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2023, Volume 65 elocation e52

Resumo: En | Texto: En | PDF: En

ABSTRACT Health care workers (HCW) are the frontline workforce for COVID-19 patient care and, consequently, are exposed to SARS-CoV-2 infection due to close contact to infected patients. Here, we evaluate the prevalence of SARS-CoV-2 infection among HCW from an infectious disease hospital, reference center for COVID-19 care in the metropolitan area of Sao Paulo city, Brazil. Among 2,204 HCW, 1,417 (64.29%) were subjected to detection of anti-SARS-CoV-2 antibodies by chemiluminescent immunoassay. Out of the total, 271 (19.12%) presented anti-SARS-CoV-2 antibodies. Prevalence varied according to HCW categories. The highest prevalence was observed in workers from outsourced companies, cooks and kitchen assistants, hospital cleaning workers, and maintenance workers. On the other hand, resident physicians and HCW from the institution itself presented lower prevalence (nurses, nursing assistants, physicians, laboratory technicians). Social and environmental factors are important determinants, associated with exposure in the hospital environment, which can determine the greater or lesser risk of infection by pathogens that spread rapidly by air. (HCW COVID19 COVID 19 COVID-1 consequently SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- patients Here city Brazil 2204 204 2,20 1417 1 417 1,41 64.29% 6429 64 29 (64.29% antiSARSCoV2 antiSARSCoV anti anti-SARS-CoV- immunoassay total 27 19.12% 1912 12 (19.12% categories companies assistants hand nurses, nurses (nurses technicians. technicians . technicians) determinants environment air COVID1 COVID- SARS-CoV 220 20 2,2 141 41 1,4 64.29 642 6 (64.29 anti-SARS-CoV 19.12 191 (19.12 22 2, 14 4 1, 64.2 (64.2 19.1 (19.1 64. (64. 19. (19. (64 (19 (6 (1 (

https://doi.org/10.1590/s1678-9946202365052

Historical line of airglow observations at Comandante Ferraz Brazilian Station: measurements of temperature and studies on gravity waves Station
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BAGESTON, JOSÉ VALENTIN

; WRASSE, CRISTIANO MAX

; GIONGO, GABRIEL AUGUSTO

; CORREIA, EMÍLIA

; FIGUEIREDO, COSME ALEXANDRE O.B.

; GOBBI, DELANO

; TAKAHASHI, HISAO

; BATISTA, PAULO P.

; COSTA, RICARDO A.B. DA

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Supl. 3 elocation e20210836

Resumo: En | Texto: En | PDF: En

Abstract The thermal dynamics of the upper atmosphere, especially in the mesosphere, have been improving our understanding about the effects of climate change, as well as how the dynamics and general circulation in the upper atmosphere are driven by different types of waves, such as the atmospheric gravity waves, planetary waves and atmospheric tides. In order to study the upper atmospheric temperature variability and gravity waves, several research groups have been employing the remote technique of observing the airglow emissions originated in the upper mesosphere and lower thermosphere, besides emissions from the ionosphere. INPE’s airglow group started the studies on emissions from the upper atmosphere to investigate temperature and dynamics in the mesosphere, thermosphere/ionosphere at the end of 70’s. However, only in 2001 this group sent the first airglow experiment to the Brazilian Antarctic Station Comandante Ferraz (EACF) to measure the OH (8-3) emission and temperature. From that year to 2014, several other experiments were carried out at EACF, not only to measure the temperature and airglow intensities, but also to observe gravity waves, winds and other related phenomena. This paper presents airglow experiments at EACF from 2001 to the present, including illustrations, examples of already published results, and unpublished data. change tides thermosphere ionosphere INPEs INPE s thermosphereionosphere 70s. 70s 70 s. 70’s However 200 (EACF 83 8 3 (8-3 2014 intensities phenomena present illustrations results data 7 20 (8- 201 2 (8 (

https://doi.org/10.1590/0001-3765202320210836

Multidisciplinary Scientific Cruises for Environmental Characterization in the Santos Basin – Methods and Sampling Design
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Moreira, Daniel L.

; Dalto, Adriana G.

; Figueiredo JR, Alberto G.

; Valerio, Aline M.

; Detoni, Amalia M. S.

; Bonecker, Ana C. T.

; Signori, Camila N.

; Namiki, Cláudia

; Sasaki, Dalton K.

; Pupo, Daniel V.

; Silva, Danilo A.

; Kutner, Deborah S.

; Duque-Castaño, Diana C.

; Marcon, Eduardo H.

; Gallotta, Fabiana D. C.

; Paula, Fabiana S.

; Gallucci, Fabiane

; Roque, Gabriela C. F.

; Campos, Giulia S.

; Fonseca, Gustavo

; Mattos, Gustavo

; Lavrado, Helena P.

; Silveira, Ilson C. A. da

; Costa, Jessica O.

; Santos Filho, João R. dos

; Carneiro, Juliane C.

; Moreira, Julio C.F.

; Rozo, Laura

; Araujo, Leandro F.M.

; Lazzari, Letícia

; Silva, Letícia O. da

; Michelazzo, Luan S.

; Fernandes, Luciano F.

; Dottori, Marcelo

; Araújo Jr., Marcus A. G. de

; Chuqui, Mateus G.

; Ceccopieri, Milena

; Borges-Silva, Milton

; Kampel, Milton

; Bergo, Natascha M.

; Silva, Paulo V. M.

; Tura, Pedro M.

; Moura, Rafael B. de

; Romano, Renato G.

; Martins, Renato P.

; Carreira, Renato S.

; Toledo, Rodrigo G.A.

; Bonecker, Sérgio L.C.

; Disaró, Sibelle T.

; Rodrigues, Silvana V.

; Corbisier, Thais N.

; Vicente, Thaisa M.

; Paiva, Vitor G. de

; Pellizari, Vivian H.

; Belo, Wellington C.

; Brandini, Frederico P.

; Sousa, Silvia H.M

Ocean and Coastal Research

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2023, Volume 71 Supl. 3 elocation e23022

Resumo: En | Texto: En | PDF: En

Abstract The Santos Basin (SB) is the main petroliferous basin in the Brazilian continental margin and one of the most studied marine areas in Brazil. However, historical data suggest that new efforts should be carried out to acquire quantitative biological data, especially in the deep sea, to establish the baseline of essential ocean variables in different ecosystems for future monitoring programs. The Brazilian energy company Petrobras planned and executed 24 oceanographic cruises over a period of 2 years to assess the benthic (SANSED cruise) and pelagic (SANAGU cruise) systems of the SB (356 days at sea in 2019 and 2021/2022). These efforts were part of the Santos Project, which comprised a comprehensive environmental study aimed at investigating benthic and pelagic variables to characterize ecology, biogeochemistry, thermohaline properties of water masses, and ocean circulation patterns, geomorphology, and sedimentology, as well as organic and inorganic chemistry. Here we present the detailed sampling designs and the field methods employed on board, during the SB scientific cruises. All sampling protocols were based on standardized approaches. For the benthos analyses, triplicate sediment samples were performed using a GOMEX-type box corer (0.25 m²) or a large modified Van Veen grab (0.75 m²) at 100 stations ranging from 25 to 2400 m depth. At each station, 25 geochemical and physico-chemical parameters were analyzed in addition to micro-, meio-, and macrofauna and living foraminifera samples. For the pelagic system, 60 stations were selected to investigate the plankton community, ranging in size from pico- to macroplankton, through vertical, horizontal, and oblique net hauls (20, 200, and 500 μm mesh size), as well as 25 biogeochemical parameters collected with an aid of a CTD-rosette sampler. Part of this scientific information also serves the Regional Environmental Characterization Project (PCR-BS) in support of Petrobras’ Santos Basin drilling licensing process led by the Brazilian Environmental Agency – IBAMA. This project contributes to the sustainable development of the SB, in line with the guidelines of the United Nations Decade of Ocean Science for Sustainable Development. (SB Brazil However programs SANSED cruise SANAGU 356 (35 201 2021/2022. 20212022 2021/2022 . 2021 2022 2021/2022) ecology biogeochemistry masses patterns geomorphology sedimentology chemistry board approaches analyses GOMEXtype GOMEX type 0.25 025 0 (0.2 m² 0.75 075 75 (0.7 10 240 depth station physicochemical physico chemical micro, micro , micro- meio, meio meio- system 6 community pico macroplankton vertical horizontal 20, 20 (20 200 50 size, size) CTDrosette CTD rosette sampler PCRBS PCR BS (PCR-BS IBAMA Development 35 (3 2021202 2021/202 202 0.2 02 (0. 0.7 07 7 1 (2 5 3 ( 202120 2021/20 0. (0 20212 2021/2 2021/

https://doi.org/10.1590/2675-2824071.22072dlm

Streptococcus constellatus causing concomitant extra and intracranial abscesses complicated with sagittal sinus thrombosis
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Farias, Luís Arthur Brasil Gadelha

; Firmino, Natália Nogueira

; Sousa, Marcos Maciel

; Lira, Mateus Lavor

; Meireles, Leonardo Nogueira

; Stolp, Ângela Maria Veras

; Maia, Kelma Maria

; Costa, Silvia Figueiredo

; Perdigão Neto, Lauro Vieira

Revista do Instituto de Medicina Tropical de São Paulo

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2023, Volume 65 elocation e10

Resumo: En | Texto: En | PDF: En

ABSTRACT Streptococcus constellatus is a gram-positive coccus member of the Streptococcus anginosus group (SAG). It can be found in the oral flora, and may cause abscess more commonly in the gastrointestinal tract, lungs, and heart. Brain abscesses are severe neurological infections with high mortality rates. Streptococcus species other than S. pneumoniae are rare causes of brain abscesses. This case report highlights a severe case of extra and intracranial abscesses due to S. constellatus in an immunocompetent host grampositive gram positive SAG. SAG . (SAG) flora tract lungs heart rates S (SAG

https://doi.org/10.1590/s1678-9946202365010

Saprochaete clavata invasive infection: characterization, antifungal susceptibility, and biofilm evaluation of a rare yeast isolated in Brazil infection characterization susceptibility
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Kraft, Letícia

; Ribeiro, Victoria Stadler Tasca

; Petroski, Luiz Pedro

; Herai, Roberto Hirochi

; Peronni, Kamila Chagas

; Figueiredo, David Livingstone Alves

; Motta, Fábio Araujo

; Tuon, Felipe Francisco

Revista do Instituto de Medicina Tropical de São Paulo

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2023, Volume 65 elocation e12

Resumo: En | Texto: En | PDF: En

ABSTRACT Rare emerging pathogens such as Saprochaete clavata are associated with invasive fungal diseases, high morbidity, mortality, rapidly fatal infections, and outbreaks. However, little is known about S. clavata infections, epidemiology, risk factors, treatment, biofilms, and disease outcomes. The objective of this study was to describe a new case of severe S. clavata infection in a patient diagnosed at a referral children’s hospital in Brazil, including antifungal minimal inhibitory concentration, S. clavata biofilm characterization, and molecular characterization. The S. clavata isolated from an immunocompromised 11-year-old male patient was characterized using MALDI-TOF, Gram staining, scanning electron microscopy (SEM), and next generation sequencing (NGS) of genomic DNA. Biofilm production was also evaluated in parallel with determining minimal inhibitory concentration (MIC) and biofilm sensitivity to antifungal treatment. We observed small to medium, whitish, farinose, dry, filamentous margin colonies, yeast-like cells with bacillary features, and biofilm formation. The MALDI-TOF system yielded a score of ≥ 2,000, while NGS confirmed S. clavata presence at the nucleotide level. The MIC values (in mg L-1) for tested drugs were as follows: fluconazole = 2, voriconazole ≤ 2, caspofungin ≥ 8, micafungin = 2, amphotericin B = 4, flucytosine ≤ 1, and anidulafungin = 1. Amphotericin B can be active against S. clavata biofilm and the fungus can be susceptible to new azoles. These findings were helpful for understanding the development of novel treatments for S. clavata-induced disease, including combined therapy for biofilm-associated infections. diseases morbidity mortality infections outbreaks However S epidemiology factors treatment biofilms outcomes childrens children s Brazil characterization 11yearold yearold 11 year old MALDITOF, MALDITOF MALDI TOF, TOF staining SEM, SEM , (SEM) (NGS DNA (MIC medium whitish farinose dry colonies yeastlike yeast like features formation 2000 2 000 2,000 level L1 L 1 L-1 follows 8 4 azoles clavatainduced induced biofilmassociated (SEM 200 00 2,00 L- 20 0 2,0

https://doi.org/10.1590/s1678-9946202365012

10.

Do Investments in Innovation and Quality Management Systems Ensure Superior Financial Performance? A Quantitative Study of Brazilian Publicly Traded Companies
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Bernardino, Lis Lisboa

; Figueiredo, Paulo S.

; Jesus, Abel Ribeiro de

; Soares Filho, Flávio Garcia de Oliveira

BBR. Brazilian Business Review

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Nov 2022, Volume 19 Nº 6 Páginas 685 - 708

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Investimentos em inovação e sistemas de gestão da qualidade há muito tempo têm se apresentado como instrumentos impulsionadores do desempenho organizacional. No Brasil, pesquisas empíricas, sistemáticas e rigorosas que investiguem tais relações ainda são pouco exploradas. Tendo em vista o panorama descrito, este estudo objetivou verificar, por meio de regressões lineares múltiplas, como investimentos em inovação, adoção da metodologia seis sigma e adoção da certificação ISO 9001 impactam o desempenho financeiro, em termos de lucratividade das 101 empresas brasileiras de capital aberto que compuseram a amostra deste estudo no exercício de 2019. Os resultados das regressões demonstram indícios de que as empresas brasileiras de capital aberto estão obtendo pouco êxito em termos de resultados financeiros através de seus esforços em Seis Sigma e que esforços em P&D e a certificação ISO 9001 exercem impacto positivo e significante na lucratividade, por meio do índice ROA. Além disso, a interação entre ISO 9001 e P&D chegou próximo da significância, indicando um possível efeito sinergético a ser testado em estudos futuros. Além da contribuição para o campo empresarial, auxiliando empresas a direcionarem seus esforços para iniciativas capazes de impactar positivamente a lucratividade, tais achados contribuem também para o avanço do conhecimento acadêmico.

ABSTRACT Investments in innovation and quality management systems have long been presented as tools that can boost organizational performance. In Brazil, empirical, systematic, and rigorous research on such relations on such relations is still scarce. Given this context, this study sought to verify, using multiple linear regressions, how investments in innovation, and adoption of the six sigma methodology and ISO 9001 certification, impacted the financial performance, in terms of profitability, of the 101 Brazilian publicly traded companies comprising the study sample in fiscal year 2019. Regression results shows evidence that Brazilian publicly traded companies are having little success in regards to financial results by their six sigma efforts, and that R&D efforts and ISO 9001 certification exert positive and significant impact on profitability, via the ROA index. The interaction between ISO 9001 and R&D came close to significance, indicating a possible synergistic effect to be tested in future studies. Besides contributions to the entrepreneurial field, aiding companies to direct their efforts toward initiatives capable of positively impacting profitability, such findings also help advance academic knowledge.

https://doi.org/10.15728/bbr.2022.19.6.6.en

11.

First case report of monkeypox in Brazil: clinical manifestations and differential diagnosis with sexually transmitted infections
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Lima, Evelyn Lepka de

; Barra, Luiz Alberto Costa

; Borges, Luciana Marques Sansão

; Medeiros, Lucas Alberto

; Tomishige, Marcia Y. S.

; Santos, Lucas de Souza Loureiro Abbud

; Silva, Anderson José Dias da

; Rodrigues, Camila Cristina Martini

; Azevedo, Luiz Cesar Fernandes de

; Villas-Boas, Lucy Santos

; Silva, Camila Alves Maia da

; Coletti, Thaís Moura

; Manuli, Erika R.

; Claro, Ingra Morales

; Romano, Camila Malta

; Ramundo, Mariana Severo

; Moutinho, Tomas

; Sabino, Ester Cerdeira

; Lindoso, José Angelo Lauletta

; Figueiredo-Mello, Claudia

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e54

Resumo: En | Texto: En | PDF: En

ABSTRACT In 2022, an outbreak of monkeypox is being reported in non-endemic areas, with unusual clinical manifestations. The detailed clinical description of the first patient that received the diagnosis of monkeypox in Brazil is reported here, whose clinical manifestations can easily lead to misdiagnosis of sexually transmitted infections. A 41 years old male presented to an emergency room with a vesicular rash with eight days of evolution. He had traveled to Portugal and Spain and reported non-penetrative sexual involvement with three different male individuals. On the third day of symptoms, he sought medical care and received empirical treatment directed to sexually transmitted infections. As the symptoms did not improve, he sought medical attention at an infectious disease referral center presenting, on admission, an ulcerated penile lesion with central necrotic crusts, a disseminated pleomorphic skin rash and an oropharyngeal ulcer. The monkeypox diagnosis was suspected due to the characteristics of the lesions and the history of intimate contact with casual partners, and it was later confirmed by sequencing the almost complete monkeypox genome. The patient was hospitalized for pain control, which required opiate administration. He developed a secondary bacterial infection on the penile lesions, which were treated with oral antibiotics. He was discharged after 14 days, with lesions in process of re-epithelialization. Given the current outbreak, we must consider the possibility of monkeypox in patients with suggestive lesions, anywhere on the body (including the genitals), added to an epidemiological link or history of intimate contact with strangers or casual partners.

https://doi.org/10.1590/s1678-9946202264054

12.

MRSA outbreak in a Neonatal Intensive Care Unit in a developed country: importance of rapid detection of reservoirs and implementation of intervention measures
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Moura, Maria Luísa

; Rizek, Camila Fonseca

; Aguiar, Elisa

; Barros, Ana Natiele da Silva

; Costa, Sibeli

; Santos, Sania Alves dos

; Marchi, Ana Paula

; Gibelli, Maria Augusta Bento Cicaroni

; Tragante, Carla Regina

; Araújo, Maria Rita Elmor de

; Rossi, Flavia

; Guimaraes, Thais

; Costa, Silvia Figueiredo

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e58

Resumo: En | Texto: En | PDF: En

ABSTRACT We described a MRSA bloodstream infection outbreak that was rapidly identified and controlled in a Neonatal Intensive Care Unit after implementation of a bundle of measures, including PCR-screening and HCW decolonization. We found 35% of healthcare workers(HCW) colonized with S. aureus by PCR, one of them that presented skin lesion positive for MSSA (same clone and spa type than two patients). Our findings raise the hypothesis that the outbreak could be related to HCW colonization.

https://doi.org/10.1590/s1678-9946202264058

13.

Shotgun metagenomic sequencing of the first case of monkeypox virus in Brazil, 2022
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Claro, Ingra Morales

; Romano, Camila Malta

; Candido, Darlan da Silva

; Lima, Evelyn Lepka de

; Lindoso, José Angelo Lauletta

; Ramundo, Mariana Severo

; Moreira, Filipe Romero Rebello

; Barra, Luiz Alberto Costa

; Borges, Luciana Marques Sansão

; Medeiros, Lucas Alberto

; Tomishige, Marcia Y. S.

; Moutinho, Tomas

; Silva, Anderson José Dias da

; Rodrigues, Camila Cristina Martini

; Azevedo, Luiz Cesar Fernandes de

; Villas-Boas, Lucy Santos

; Silva, Camila Alves Maia da

; Coletti, Thaís Moura

; Manuli, Erika R.

; O’Toole, Aine

; Quick, Joshua

; Loman, Nicholas

; Rambaut, Andrew

; Faria, Nuno R.

; Figueiredo-Mello, Claudia

; Sabino, Ester Cerdeira

Revista do Instituto de Medicina Tropical de São Paulo

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2022, Volume 64 elocation e48

Resumo: En | Texto: En | PDF: En

ABSTRACT Monkeypox virus (MPXV), a zoonotic virus endemic to the African continent, has been reported in 33 non-endemic countries since May 2022. We report an almost complete genome of the first confirmed case of MPXV in Brazil. Shotgun metagenomic sequencing was completed in 18 hours, from DNA extraction to consensus sequence generation.

https://doi.org/10.1590/s1678-9946202264048

14.

Endoscopy infection control strategy during the COVID-19 pandemic: experience from a tertiary cancer center in Brazil
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Pombo, Amanda A.M.

; Lenz, Luciano

; Paulo, Gustavo A.

; Santos, Mônica A.

; Tamae, Patricia K.

; Santos, Alisson L.D.R.

; Rezende, Daniel T.

; Martins, Bruno

; Kawaguti, Fabio S.

; Pennachi, Caterina M.P.S.

; Gusmon-Oliveira, Carla C.

; Uemura, Ricardo S.

; Geiger, Sebastian

; Lima, Marcelo S.

; Baba, Elisa R.

; Figueiredo, Viviane R.

; Safatle-Ribeiro, Adriana

; Maluf-Filho, Fauze

; Ribeiro-Júnior, Ulysses

Clinics

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2021, Volume 76 elocation e2280

Resumo: En | Texto: En | PDF: En

OBJECTIVES: Strategic planning for coronavirus disease (COVID-19) care has dominated the agenda of medical services, which have been further restricted by the need for minimizing viral transmission. Risk is particularly relevant in relation to endoscopy procedures. This study aimed to describe a contingency plan for a tertiary academic cancer center, define a strategy to prioritize and postpone examinations, and evaluate the infection rate among healthcare workers (HCWs) in the endoscopy unit of the Cancer Institute of the State of São Paulo (ICESP). METHODS: We created a strategy to balance the risk of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and to mitigate the effects of postponing endoscopic procedures in oncological patients. A retrospective analysis of prospectively collected data on all endoscopies between March and June 2020 compared with those during the same period in 2019 was carried out. All HCWs were interviewed to obtain clinical data and SARS-CoV-2 test results. RESULTS: During the COVID-19 outbreak, there was a reduction of 55% in endoscopy cases in total. Colonoscopy was the most affected modality. The total infection rate among all HCWs was 38%. None of the senior digestive endoscopists had COVID-19. However, all bronchoscopists had been infected. One of three fellows had a serological diagnosis of COVID-19. Two-thirds of all nurses were infected, whereas half of all technicians were infected. CONCLUSIONS: In this pandemic scenario, all endoscopy services must prioritize the procedures that will be performed. It was possible to maintain some endoscopic procedures, including those meant to provide nutritional access, tissue diagnosis, and endoscopic resection. Personal protective equipment (PPE) seems effective in preventing transmission of COVID-19 from patients to digestive endoscopists. These measures can be useful in planning, even for pandemics in the future.

https://doi.org/10.6061/clinics/2021/e2280 501 downloads

15.

The role of motivation in the results of total productive maintenance
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Guedes, Micaela

; Figueiredo, Paulo S.

; Pereira-Guizzo, Camila Sousa

; Loiola, Elisabeth

Production

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2021, Volume 31 elocation e20200057

Resumo: En | Texto: En | PDF: En

Abstract Paper aims The aim is to analyze the role of motivation of work teams in production lines in the operational results obtained with the implementation of a Total Productive Maintenance (TPM) program in a single company. Originality The areas of industrial production and maintenance require that human factors influencing performance be continuously investigated and cannot focus exclusively on the reliability of equipment and systems. Studies that contemplate these factors are relatively scarce but of great value for companies and society. Research method This is an exploratory case study that used a measurement of motivation with two teams of employees who participated in the implementation of TPM, comparing it to measures of operational performance. Unstructured interviews and nonparticipant observation were also used for data collection. Main findings The level of motivation of the team was positively associated with a change in operational performance, and the implementation of TPM had a positive impact on performance. Implications for theory and practice This study contributes to the behavioral operations management literature by showing empirical evidence that operational results may depend on motivated workers during TPM implementation. Managers must pay attention to the factors that determine the motivation of work teams when implementing improvement programs.

https://doi.org/10.1590/0103-6513.20200057 481 downloads

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