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1.
Effect of ozone oil and non-surgical periodontal treatment in patients with type 2 diabetes. In-vivo and in-vitro studies with fibroblasts and Candida albicans
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CARMO, Raquel Alves do
; CÖRNER, Ana Carolina Organista
; MARTINS, Eduardo Ferreira
; OUVERNEY, Gabriel
; THURLER JÚNIOR, Julio Cesar
ROBBS, Bruno Kaufmann
PASCOAL, Vinicius D’Avila Bitencourt
ESPOSITO, Elisa
CAPELO, Luciane Portas
CAMARGO, Gabriela Alessandra da Cruz Galhardo




Abstract Aim To evaluate the clinical effectiveness of ozonated sunflower oil (Oz) as an adjunctive of non-surgical periodontal therapy in patients with type 2 diabetes mellitus (DM2), on fibroblast cell viability and migration and the effectiveness of Oz on a Candida albicans (C. albicans) culture. Methodology In total, 32 sites in 16 DM2 with moderate to advanced periodontal disease with periodontal pocket depths ≥5mm were selected. The treatments were divided into two groups: control, saline solution (SS) as an adjunctive of scaling and root planing (SRP+SS), and test, Oz as an adjunctive of SRP (SRP+Oz). Hematological [fasting glucose level (FGL) and hemoglobin A1c (HbA1c)] and microbiological samples were collected from the participants at baseline and three months after periodontal treatment and the microbiological samples were analyzed by PCR. C. albicans was previously tested by the agar diffusion test. The effect of Oz was tested on cell viability and fibroblast migration. Results The groups showed no statistically significant differences (paired t-test-p>0.05) regarding hematological parameters, FGL (median - baseline 171.41, 3 months 164mg/dL), and HbA1c (baseline 8%, 3 months 7.5%) (Kruskal-Wallis One-Way Nonparametric-p>0.05) after periodontal therapy. The groups showed statistical differences for periodontal parameters between baseline and three months (paired t-test-p<0.05). PCR analysis showed a reduction in the percentage of C. albicans in the SRP+Oz group after three months (McNemar’s test-p=0.002). Cell viability was lower in the high glucose Dulbecco’s modified Eagle’s medium (4500 mg/L) than in low glucose (1000 mg/L) (RM-ANOVA-p<0.0001). The wound healing test showed reduced fibroblast migration (one-way ANOVA with Dunnett’s post-test-p<0.01). Oz showed high C. albicans antifungal inhibition (Kruskal-Wallis test-p=0.0001). Conclusions SRP+Oz effectively reduced C. albicans in-vitro and in-vivo but showed no clinical improvements compared to the control. Cell viability and wound healing of fibroblasts showed no improvements.
2.
Safety of two-dose schedule of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan) and heterologous additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised and immunocompetent individuals
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Miyaji, Karina Takesaki
; Ibrahim, Karim Yaqub
; Infante, Vanessa
; Moreira, Raquel Megale
; Santos, Carolina Ferreira dos
Belizário, Juliana de Cássia
Pinto, Maria Isabel de Moraes
Marinho, Ana Karolina Barreto Berselli
Pereira, Juliana Marquezi
Mello, Liliane Saraiva de
Silva, Vitor Gabriel Lopes da
Sato, Paula Keiko
Strabelli, Tânia Mara Varejão
Ragiotto, Lucas
Pacheco, Pedro Henrique Theotonio de Mesquita
Braga, Patricia Emilia
Loch, Ana Paula
Precioso, Alexander Roberto
Sartori, Ana Marli Christovam
França, João Ítalo
Lima, Marcos Alves de
Ando, Mauricio Cesar Sampaio
Rodrigues, Camila Cristina Martini
Song, Alice Tung Wan
Lara, Amanda Nazareth
Belizário, Ana Cristina
Lima, Anna Helena Simões Bortulucci de
Zanetti, Ariane Cristina Barboza
Paulo, Audrey Rose da Silveira Amancio de
Rosa, Barbara Miranda dos Santos
Moraes, Bruna Del Guerra de Carvalho
Oliveira, Bruna Ribeiro de
Picone, Camila de Melo
Aranda, Carolina Sanches
Troli, Carolinne Paioli
Kokron, Cristina M.
Terrabuio, Debora Raquel Benedita
Abdala, Edson
David Neto, Elias
Nakanishi, Érika Yoshie Shimoda
Lima, Fabiana Mascarenhas Souza
Firmino, Fabio Batista
Santos, Fernanda Barone Alves dos
Bacal, Fernando
Fatobene, Giancarlo
Santana, Jaqueline Oliveira
Kalil, Jorge
Barbosa, Julia
Gonçalves, Leandro Peres
Otuyama, Leonardo Jun
Pierrotti, Ligia Camera
Compte, Livia Caroline Mariano
Marinho, Livia
Chaer, Livia Netto
Seguro, Luis Fernando
Azevedo, Luiz Sergio
Ueda, Márcia Aiko
Terreri, Maria Teresa
Barros, Myrthes Anna Maragna Toledo
Grecco, Octávio
Sejas, Odeli Nicole Encinas
Musqueira, Priscila Tavares
Ito, Raquel Keiko de Luca
Teixeira, Samia Silveira Souza
Fidalgo, Serafim
Costa, Silvia Figueiredo
Campos, Silvia Vidal
Fernandes, Tamiris Hinsching
Rocha, Vanderson Geraldo
Coelho, Vivian Caso




Revista do Instituto de Medicina Tropical de São Paulo
- Métricas do periódico
ABSTRACT Immunocompromised individuals were considered high-risk for severe disease due to SARS COV-2 infection. This study aimed to describe the safety of two doses of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan), followed by additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised (IC) adults, compared to immunocompetent/healthy (H) individuals. This phase 4, multicenter, open label study included solid organ transplant and hematopoietic stem cell transplant recipients, cancer patients and people with inborn errors of immunity with defects in antibody production, rheumatic, end-stage chronic kidney or liver disease, who were enrolled in the IC group. Participants received two doses of CoronaVac and additional doses of mRNA BNT162b2. Adverse reactions (AR) data were collected within seven days after each vaccination. Serious adverse events and of special interest (AESI) were monitored throughout the study. We included 241 immunocompromised and 100 immunocompetent subjects. Arthralgia, fatigue, myalgia, and nausea were more frequent in the IC group after CoronaVac. Following the first additional dose of mRNA BNT162, pain, induration, and tenderness at injection site, fatigue and myalgia were more frequent in the H group. A heart transplant recipient had a graft rejection temporally associated with the second CoronaVac dose, but there was no literature evidence of causal association. Four cases of AESI were considered related to the vaccine: three erythema multiforme after CoronaVac, all in IC participants, and one paresthesia after mRNA, in a H participant. Our findings were comparable to other studies that evaluated the safety of COVID-19 vaccines in different immunocompromised populations. Both vaccines were safe for immunocompromised participants.
3.
Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies
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Ferreira, Juliana Carvalho
; Vianna, Arthur Oswaldo de Abreu
; Pinheiro, Bruno Valle
; Maia, Israel Silva
; Baldisserotto, Sérgio Vasconcellos
; Isola, Alexandre Marini
; Cavalcanti, Alexandre Biasi
Gama, Ana Maria Casati Nogueira da
Rocha, Angelo Roncalli Miranda
Oliveira, Antonio Gonçalves de
Serpa Neto, Ary
Farias, Augusto Manoel de Carvalho
Orlando, Bianca Rodrigues
Esteves, Bruno da Costa
Mazza, Bruno Franco
Silveira, Camila de Freitas Martins Soares
Carvalho, Carlos Roberto Ribeiro de
Toufen Junior, Carlos
Barbas, Carmen Silvia Valente
Teixeira, Cassiano
Silveira, Débora Dutra da
Medeiros, Denise Machado
Parolo, Edino
Costa, Eduardo Leite Vieira
Caser, Eliana Bernadete
Oliveira, Ellen Pierre de
Banholzer, Eric Grieger
Carvalho, Erich Vidal
Amorim, Fabio Ferreira
Saddy, Felipe
Gonçalves, Fernanda Alves Ferreira
Galas, Filomena Regina Barbosa Gomes
Zanatta, Giovanna Carolina Gardini
Silva, Gisele Sampaio
Westphal, Glauco Adrieno
Matos, Gustavo Faissol Janot de
Souza, João Claudio Emmerich de
Silva Junior, João Manoel
Valiatti, Jorge Luis dos Santos
Nascimento Junior, José Ribamar do
Rocco, Jose Rodolfo
Hajjar, Ludhmila Abrahão
Forgiarini Junior, Luiz Alberto
Malbuisson, Luiz Marcelo Sá
Holanda, Marcelo Alcantara
Amato, Marcelo Britto Passos
Park, Marcelo
Oliveira, Marco Antonio da Rosa e
Reis, Marco Antonio Soares
Tavares, Marcos Soares
Souza, Mario Henrique Dutra de
Damasceno, Marta Cristina Pauleti
Lira-Batista, Marta Maria da Silva
Pattacini, Max Morais
Assunção, Murillo Santucci Cesar de
Oliveira, Neymar Elias de
Franzosi, Oellen Stuani
Rocco, Patricia Rieken Macedo
Caruso, Pedro
Silva, Pedro Leme
Mendes, Pedro Vitale
Duarte, Pericles Almeida Delfino
Santa Neto, Renato Fabio Alberto Della
Rodrigues, Ricardo Goulart
Cordioli, Ricardo Luiz
Palazzo, Roberta Fittipaldi
Goldwasser, Rosane
Pinheiro, Sabrina dos Santos
Justino, Sandra Regina
Nemer, Sergio Nogueira
Oliveira, Vanessa Martins de
Silva, Vinicius Zacarias Maldaner da
Nedel, Wagner Luis
Bellissimo-Rodrigues, Wanessa Teixeira
Oliveira Filho, Wilson de






ABSTRACT Mechanical ventilation can be a life-saving intervention, but its implementation requires a multidisciplinary approach, with an understanding of its indications and contraindications due to the potential for complications. The management of mechanical ventilation should be part of the curricula during clinical training; however, trainees and practicing professionals frequently report low confidence in managing mechanical ventilation, often seeking additional sources of knowledge. Review articles, consensus statements and clinical practice guidelines have become important sources of guidance in mechanical ventilation, and although clinical practice guidelines offer rigorously developed recommendations, they take a long time to develop and can address only a limited number of clinical questions. The Associação de Medicina Intensiva Brasileira and the Sociedade Brasileira de Pneumologia e Tisiologia sponsored the development of a joint statement addressing all aspects of mechanical ventilation, which was divided into 38 topics. Seventy-five experts from all regions of Brazil worked in pairs to perform scoping reviews, searching for publications on their specific topic of mechanical ventilation in the last 20 years in the highest impact factor journals in the areas of intensive care, pulmonology, and anesthesiology. Each pair produced suggestions and considerations on their topics, which were presented to the entire group in a plenary session for modification when necessary and approval. The result was a comprehensive document encompassing all aspects of mechanical ventilation to provide guidance at the bedside. In this article, we report the methodology used to produce the document and highlight the most important suggestions and considerations of the document, which has been made available to the public in Portuguese.
4.
Periódicos científicos na área Comunicação e Informação: consolidação do índice h e as questões éticas sobre sua utilização
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D'Almonte, Edson Fernando
; Pinho, Fabio Assis
; Oliveira, Thaiane Moreira de
; Santos Junior, Marcelo Alves dos
; Araújo, Ronaldo Ferreira de
; Temer, Ana Carolina Rocha Pessoa
; Marques, Francisco Paulo Jamil
; Bruck, Mozahir Salomão
.








Resumo Trata-se de uma pesquisa sobre o impacto do uso do índice h na avaliação de periódicos científicos. Mais exatamente, pretende-se verificar a utilização de tais métricas para classificar um conjunto de periódicos brasileiros da área Comunicação e Informação da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. A abordagem metodológica compreende um exame exploratório por meio do qual 20 revistas científicas da área tiveram seus dados extraídos a partir do Google Scholar Metrics no dia 4 de julho de 2022. A coleta também envolveu registro dos metadados de autoria, URL da publicação, periódico, ano e total de citações recebidas. A análise dos dados foi realizada a partir de um cálculo para medida de autocitação do próprio periódico e, em seguida, um periódico teve sua análise destacada. Os resultados demonstraram que duas revistas se destacaram na porcentagem de citação, volume de citações advindo de erros de metadados e falta de metadados estruturados para análise da fonte. Assim sendo, a despeito do índice h ser uma métrica interessante para a avaliação de periódicos na área Comunicação e Informação, considera-se que ela poderia ser complementada por avaliações qualitativas capazes de compreender os desafios éticos necessários para garantir uma avaliação justa e adequada da pesquisa acadêmica.
Abstract This research investigates the impact of using the h-index in the evaluation of scientific journals. Specifically, we aim to assess the use of these metrics to categorize a set of Brazilian journals from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Communication and Information area. The methodological approach involves an exploratory examination in which data from 20 scientific journals in the area were extracted from Google Scholar Metrics on July 4, 2022. The data collection also included recording authorship metadata, publication URL, periodical, year, and the total number of citations received. Data analysis was conducted through a calculation to measure each journal's self-citation, and one journal had its analysis highlighted. The results demonstrated that two journals stood out in terms of citation percentage, the volume of citations resulting from metadata errors, and the lack of structured metadata for source analysis. Therefore, despite the h-index being an interesting metric for evaluating journals in the Communication and Information area, it is considered that it could be complemented by qualitative evaluations capable of understanding the ethical challenges necessary to ensure a fair and adequate evaluation of academic research.
5.
Immunogenicity of COVID-19 adsorbed inactivated vaccine (CoronaVac) and additional doses of mRNA BNT162b2 vaccine in immunocompromised adults compared with immunocompetent persons COVID19 COVID 19 COVID-1 CoronaVac (CoronaVac BNTb BNT b BNT162b COVID1 1 COVID-
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Ibrahim, Karim Yaqub
; Moreira, Raquel Megale
; Santos, Carolina Ferreira dos
; Strabelli, Tânia Mara Varejão
; Belizário, Juliana de Cássia
; Pinto, Maria Isabel de Moraes
; Marinho, Ana Karolina Barreto Berselli
; Pereira, Juliana Marquezi
; Mello, Liliane Saraiva de
; Ando, Mauricio Cesar
; Silva, Vitor Gabriel Lopes da
; Sato, Paula Keiko
; Lima, Marcos Alves de
; França, João Italo Dias
; Loch, Ana Paula
; Miyaji, Karina Takesaki
; Infante, Vanessa
; Precioso, Alexander Roberto
; Sartori, Ana Marli Christovam
.



















Revista do Instituto de Medicina Tropical de São Paulo
- Métricas do periódico
ABSTRACT Inactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) individuals. Adults with solid organ transplant (SOT), hematopoietic stem cell transplant, cancer, inborn immunity errors or rheumatic diseases were included in the IC group. Immunocompetent adults were used as control group for comparison. Participants received two CoronaVac doses within a 28-day interval. IC received two additional BNT162b2 doses and H received a third BNT162b2 dose (booster). Blood samples were collected at baseline, 28 days after each dose, pre-booster and at the trial end. We used three serological tests to detect antibodies to SARS-CoV-2 nucleocapsid (N), trimeric spike (S), and receptor binding domain (RBD). Outcomes included seroconversion rates (SCR), geometric mean titers (GMT) and GMT ratio (GMTR). A total of 241 IC and 100 H adults participated in the study. After two CoronaVac doses, IC had lower SCR than H: anti-N, 33.3% vs 79%; anti-S, 33.8% vs 86%, and anti-RBD, 48.5% vs 85%, respectively. IC also showed lower GMT than H: anti-N, 2.3 vs 15.1; anti-S, 58.8 vs 213.2 BAU/mL; and anti-RBD, 22.4 vs 168.0 U/mL, respectively. After the 3rd and 4th BNT162b2 doses, IC had significant anti-S and anti-RBD seroconversion, but still lower than H after the 3rd dose. After boosting, GMT increased in IC, but remained lower than in the H group. CoronaVac two-dose schedule immunogenicity was lower in IC than in H. BNT162b2 heterologous booster enhanced immune response in both groups. COVID19 COVID 19 COVID-1 scarce BNTb BNT b BNT162b (IC (H SOT, SOT , (SOT) cancer comparison 28day day interval booster. . (booster) baseline 2 prebooster pre end SARSCoV2 SARSCoV SARS CoV SARS-CoV- N, N (N) S, S (S) RBD. RBD (RBD) SCR, (SCR) (GMT GMTR. GMTR (GMTR) 24 10 study antiN, antiN anti anti-N 333 33 3 33.3 79% 79 antiS, antiS 338 8 33.8 86 86% antiRBD, antiRBD RBD, 485 48 5 48.5 85 85% respectively 23 2. 15.1 151 15 1 588 58 58. 2132 213 213. BAU/mL BAUmL BAU mL 224 22 4 22. 1680 168 0 168. UmL U U/mL rd th boosting twodose groups COVID1 COVID- (SOT (booster SARS-CoV (N (S (RBD (SCR (GMTR 33. 7 48. 15. 21 16
6.
Development of mulch films from biodegradable polymer and agro-industrial waste agroindustrial agro industrial
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França, Railha Antunes de
; Rosa, Ana Carolina Ferreira dos Santos
; Braz, Cristiano José de Farias
; Barbosa, Renata
; Alves, Tatianny Soares
.





Abstract Plasticulture improves crop quality and yield through polymeric films, but their improper disposal harms the environment due to humidity and contamination. This study aimed to develop biodegradable mulch films using soybean and peanut hulls and poly (butylene-adipate-co-terephthalate) (PBAT). The residues were characterized by thermogravimetric analysis and mulch films were evaluated by water absorption, contact angle and mechanical properties. The thermal behavior of the residues indicated stability below 200ºC. The agro-waste improved hydrophobicity but increased the water absorption values of the films by up to 18.5x (PBAT/SH5 after 14 days). Micrographs obtained by scanning electron microscopy indicated an important distribution of residue particles and formation of agglomerates, leading to lower mechanical performance. The study found that agro-industrial residues in powder form can be added to the polymeric matrix to produce biodegradable mulch films through traditional processing techniques. This approach has the potential to contribute to a more sustainable production system. contamination butyleneadipatecoterephthalate butylene adipate co terephthalate (butylene-adipate-co-terephthalate PBAT. PBAT . (PBAT) properties 200ºC ºC agrowaste agro waste 185x x 18 5x PBAT/SH5 PBATSH5 PBATSH SH5 SH (PBAT/SH 1 days. days days) agglomerates performance agroindustrial industrial techniques system (PBAT PBAT/SH
7.
Translation and cultural adaptation of the Positive Aspects of Caregiving Scale for caregivers of people living with dementia in Brazilian context: a methodological study context
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Pavarini, Sofia Cristina Iost
; Gratão, Aline Cristina Martins
; Campos, Camila Rafael Ferreira
; Monteiro, Diana Quirino
; Barham, Elizabeth Joan
; Orlandi, Fabiana de Souza
; Martins, Gabriela
; Barbosa, Gustavo Carrijo
; Cruz, Keila Cristianne Trindade da
; Corrêa, Larissa
; Rocha, Luana Aparecida da
; Alves, Ludmyla Caroline de Souza
; Ottaviani, Ana Carolina
.













ABSTRACT BACKGROUND: The Positive Aspects of Caregiving (PAC) scale is used to assess psychosocial benefits provided to caregivers by the task of caring. The PAC scale consists of nine items, assessed using a five-point Likert scale, with higher values indicating greater positive perceptions and gains from the caregiving experience. OBJECTIVE: To translate and culturally adapt the PAC scale for informal Brazilian caregivers of people with dementia. DESIGN AND SETTING: A methodological study was conducted at the Federal University of São Carlos. METHODS: The following stages were carried out: Translation; Synthesis of the translations; Back-translation; Evaluation by an experts’ committee; and Pre-test. RESULTS: Two independent professionals translated the PAC scale. The consensus version was obtained by merging both translations, which were back-translated into English by a third translator. The expert committee comprised three specialists in the area and project researchers. All scale items presented a Content Validity Index of 1 (CVI = 1.0), and thus remained in the pre-final version of the instrument. The instrument was pre-tested with seven caregivers of people with dementia, the majority of whom were women (57.1%), with a degree of kinship corresponding to sons/daughters (57.1%) and an average age of 55.2 (± 4.1) years. The caregivers considered it clear and understandable and made no suggestions for changes. CONCLUSION: The PAC scale was translated and culturally adapted for use by informal caregivers of people with dementia in Brazil. However, a psychometric analysis of the instrument is necessary to provide normative data for this population group. BACKGROUND (PAC caring fivepoint five point experience OBJECTIVE SETTING Carlos METHODS out Translation translations Backtranslation Back translation Back-translation experts Pretest. Pretest Pre test. test Pre-test RESULTS backtranslated back translator researchers CVI 1.0, 10 1.0 , 0 1.0) prefinal pre final pretested tested 57.1%, 571 57.1% 57 sonsdaughters sons daughters (57.1% 552 55 2 55. ± ( 4.1 41 4 years changes CONCLUSION Brazil However group 1. 57.1 5 (57.1 4. 57. (57. (57 (5
8.
Sense of mastery in caregivers of people living with dementia: translation and cultural adaptation of the Pearlin Mastery Scale dementia
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Barbosa, Gustavo Carrijo
; Ottaviani, Ana Carolina
; Monteiro, Diana Quirino
; Campos, Camila Rafael Ferreira
; Cruz, Keila Cristianne Trindade da
; Alves, Ludmyla Caroline de Souza
; Corrêa, Larissa
; Rocha, Luana Aparecida
; Martins, Gabriela
; Melo, Beatriz Rodrigues de Souza
; Barham, Elizabeth Joan
; Pavarini, Sofia Cristina Iost
; Orlandi, Fabiana de Souza
; Gratão, Aline Cristina Martins
.














ABSTRACT The sense of mastery is conceptualized as a positive aspect of care targeted at people living with dementia, a coping mechanism to reduce burden, and may represent a protective factor for caregivers’ mental and physical health. Objective: To translate and culturally adapt the Pearlin Mastery Scale for Brazil. Methods: A methodological study was conducted at the Federal University of São Carlos in which the initial translation stages were followed; synthesis; back-translation; review by the committee of judges by analyzing the Content Validity Index (CVI); and test of the pre-final version. Results: Two specialists translated the scale into Brazilian Portuguese and defined a consensus version with the researchers. Subsequently, another two specialists back-translated the consensus version, which was reviewed by three judges who are PhDs in the area, considering all scale items as very equivalent (CVI=1.0), and maintaining them in the pre-final version of the instrument. This was tested in a first group of caregivers for them to point out adjustments. The suggestions were accepted by modifying three items and, afterward, the scale was tested in a second group, which did not present difficulties answering the instrument. Conclusion: The Pearlin Mastery Scale was translated and culturally adapted for Brazil, showing equivalence. However, future psychometric analyses of the instrument are required to make it available for use in this population. dementia burden health Objective Brazil Methods followed synthesis backtranslation back back-translation CVI (CVI) prefinal pre final Results researchers Subsequently backtranslated area CVI=1.0, CVI10 CVI=1.0 , 1 0 (CVI=1.0) adjustments afterward Conclusion equivalence However population (CVI CVI1 CVI=1. (CVI=1.0 CVI=1 (CVI=1. CVI= (CVI=1 (CVI=
RESUMO O senso de domínio é conceituado como um aspecto positivo do cuidado voltado às pessoas que vivem com demência, um mecanismo de enfrentamento para reduzir a sobrecarga e que pode representar um fator protetor para a saúde mental e física do cuidador. Objetivo: Traduzir e adaptar culturalmente a Pearlin Mastery Scale para o Brasil. Métodos: Estudo metodológico conduzido na Universidade Federal de São Carlos, em que foram seguidas as etapas de tradução inicial; síntese; retrotradução; revisão pelo comitê de juízes pela análise do Índice de Validade de Conteúdo (IVC); e teste da versão pré-final. Resultados: Dois especialistas traduziram a escala para o português brasileiro e definiram uma versão consensual com os pesquisadores. Posteriormente, outros dois especialistas retrotraduziram a versão consensual, que foi revisada por três juízes doutores na área, considerando todos os itens da escala como muito equivalentes (IVC=1,0), mantendo-os na versão pré-final do instrumento. Esta foi testada em um primeiro grupo de cuidadores, a fim de se apontarem adequações. As sugestões foram acatadas mediante a modificação de três itens e, depois, a escala foi testada em um segundo grupo, o qual não apresentou dificuldades em responder ao instrumento. Conclusão: A Pearlin Mastery Scale foi traduzida e adaptada culturalmente para o Brasil, demonstrando equivalência. Entretanto, análises psicométricas futuras do instrumento são necessárias para disponibilizá-lo para uso entre essa população. demência cuidador Objetivo Brasil Métodos Carlos inicial síntese retrotradução IVC (IVC) préfinal. préfinal pré final. final Resultados pesquisadores Posteriormente área IVC=1,0, IVC10 IVC=1,0 , 1 0 (IVC=1,0) mantendoos mantendo cuidadores adequações depois Conclusão equivalência Entretanto disponibilizálo disponibilizá lo população (IVC IVC1 IVC=1, (IVC=1,0 IVC=1 (IVC=1, IVC= (IVC=1 (IVC=
9.
Prospective, randomized, controlled trial assessing the effects of a driving pressure–limiting strategy for patients with acute respiratory distress syndrome due to community-acquired pneumonia (STAMINA trial): protocol and statistical analysis plan Prospective randomized pressurelimiting pressure limiting communityacquired community acquired STAMINA trial)
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Maia, Israel Silva
; Medrado Jr, Fernando Azevedo
; Tramujas, Lucas
; Tomazini, Bruno Martins
; Oliveira, Júlia Souza
; Sady, Erica Regina Ribeiro
; Barbante, Letícia Galvão
; Nicola, Marina Lazzari
; Gurgel, Rodrigo Magalhães
; Damiani, Lucas Petri
; Negrelli, Karina Leal
; Miranda, Tamiris Abait
; Santucci, Eliana
; Valeis, Nanci
; Laranjeira, Ligia Nasi
; Westphal, Glauco Adrieno
; Fernandes, Ruthy Perotto
; Zandonai, Cássio Luis
; Pincelli, Mariangela Pimentel
; Figueiredo, Rodrigo Cruvinel
; Bustamante, Cíntia Loss Sartori
; Norbin, Luiz Fernando
; Boschi, Emerson
; Lessa, Rafael
; Romano, Marcelo Pereira
; Miura, Mieko Cláudia
; Alencar Filho, Meton Soares de
; Dantas, Vicente Cés de Souza
; Barreto, Priscilla Alves
; Hernandes, Mauro Esteves
; Grion, Cintia Magalhães Carvalho
; Laranjeira, Alexandre Sanches
; Mezzaroba, Ana Luiza
; Bahl, Marina
; Starke, Ana Carolina
; Biondi, Rodrigo Santos
Dal-Pizzol, Felipe
Caser, Eliana Bernadete
Thompson, Marlus Muri
Padial, Andrea Allegrini
Veiga, Viviane Cordeiro
Leite, Rodrigo Thot
Araújo, Gustavo
Guimarães, Mário
Martins, Priscilla de Aquino
Lacerda, Fábio Holanda
Hoffmann Filho, Conrado Roberto
Melro, Livia
Pacheco, Eduardo
Ospina-Táscon, Gustavo Adolfo
Ferreira, Juliana Carvalho
Freires, Fabricio Jocundo Calado
Machado, Flávia Ribeiro
Cavalcanti, Alexandre Biasi
Zampieri, Fernando Godinho



































ABSTRACT Background: Driving pressure has been suggested to be the main driver of ventilator-induced lung injury and mortality in observational studies of acute respiratory distress syndrome. Whether a driving pressure-limiting strategy can improve clinical outcomes is unclear. Objective: To describe the protocol and statistical analysis plan that will be used to test whether a driving pressure-limiting strategy including positive end-expiratory pressure titration according to the best respiratory compliance and reduction in tidal volume is superior to a standard strategy involving the use of the ARDSNet low-positive end-expiratory pressure table in terms of increasing the number of ventilator-free days in patients with acute respiratory distress syndrome due to community-acquired pneumonia. Methods: The ventilator STrAtegy for coMmunIty acquired pNeumoniA (STAMINA) study is a randomized, multicenter, open-label trial that compares a driving pressure-limiting strategy to the ARDSnet low-positive end-expiratory pressure table in patients with moderate-to-severe acute respiratory distress syndrome due to community-acquired pneumonia admitted to intensive care units. We expect to recruit 500 patients from 20 Brazilian and 2 Colombian intensive care units. They will be randomized to a driving pressure-limiting strategy group or to a standard strategy using the ARDSNet low-positive end-expiratory pressure table. In the driving pressure-limiting strategy group, positive end-expiratory pressure will be titrated according to the best respiratory system compliance. Outcomes: The primary outcome is the number of ventilator-free days within 28 days. The secondary outcomes are in-hospital and intensive care unit mortality and the need for rescue therapies such as extracorporeal life support, recruitment maneuvers and inhaled nitric oxide. Conclusion: STAMINA is designed to provide evidence on whether a driving pressure-limiting strategy is superior to the ARDSNet low-positive end-expiratory pressure table strategy for increasing the number of ventilator-free days within 28 days in patients with moderate-to-severe acute respiratory distress syndrome. Here, we describe the rationale, design and status of the trial. Background ventilatorinduced induced pressurelimiting limiting unclear Objective endexpiratory end expiratory lowpositive low ventilatorfree free communityacquired community Methods (STAMINA multicenter openlabel open label moderatetosevere moderate severe units 50 Outcomes inhospital hospital support oxide Conclusion Here rationale 5
RESUMO Contexto: Em estudos observacionais sobre a síndrome do desconforto respiratório agudo, sugeriu-se que a driving pressure é o principal fator de lesão pulmonar induzida por ventilador e de mortalidade. Não está claro se uma estratégia de limitação da driving pressure pode melhorar os desfechos clínicos. Objetivo: Descrever o protocolo e o plano de análise estatística que serão usados para testar se uma estratégia de limitação da driving pressure envolvendo a titulação da pressão positiva expiratória final de acordo com a melhor complacência respiratória e a redução do volume corrente é superior a uma estratégia padrão envolvendo o uso da tabela de pressão positiva expiratória final baixa do protocolo ARDSNet, em termos de aumento do número de dias sem ventilador em pacientes com síndrome do desconforto respiratório agudo devido à pneumonia adquirida na comunidade. Métodos: O estudo STAMINA (ventilator STrAtegy for coMmunIty acquired pNeumoniA) é randomizado, multicêntrico e aberto e compara uma estratégia de limitação da driving pressure com a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet em pacientes com síndrome do desconforto respiratório agudo moderada a grave devido à pneumonia adquirida na comunidade internados em unidades de terapia intensiva. Esperamos recrutar 500 pacientes de 20 unidades de terapia intensiva brasileiras e duas colombianas. Eles serão randomizados para um grupo da estratégia de limitação da driving pressure ou para um grupo de estratégia padrão usando a tabela de pressão positiva expiratória final baixa do protocolo ARDSnet. No grupo da estratégia de limitação da driving pressure, a pressão positiva expiratória final será titulada de acordo com a melhor complacência do sistema respiratório. Desfechos: O desfecho primário é o número de dias sem ventilador em 28 dias. Os desfechos secundários são a mortalidade hospitalar e na unidade de terapia intensiva e a necessidade de terapias de resgate, como suporte de vida extracorpóreo, manobras de recrutamento e óxido nítrico inalado. Conclusão: O STAMINA foi projetado para fornecer evidências sobre se uma estratégia de limitação da driving pressure é superior à estratégia da tabela de pressão positiva expiratória final baixa do protocolo ARDSnet para aumentar o número de dias sem ventilador em 28 dias em pacientes com síndrome do desconforto respiratório agudo moderada a grave. Aqui, descrevemos a justificativa, o desenho e o status do estudo. Contexto sugeriuse sugeriu clínicos Objetivo ARDSNet Métodos ventilator pNeumoniA randomizado 50 2 colombianas Desfechos resgate extracorpóreo inalado Conclusão Aqui justificativa 5
10.
A comprehensive physical functional assessment of survivors of critical care unit stay due to COVID-19 COVID19 COVID 19 COVID-1 COVID1 1 COVID-
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Volpe, Marcia Souza
; Santos, Ana Carolina Cardoso dos
; Gaspar, Sílvia
; Melo, Jade Lara de
; Harada, Gabriela
; Ferreira, Patrícia Rocha Alves
; Silva, Karina Ramiceli Soares da
; Souza, Natália Tiemi Simokomaki
; Toufen Junior, Carlos
; Chiavegato, Luciana Dias
; Amato, Marcelo Britto Passos
; Feltrim, Maria Ignez Zanetti
; Carvalho, Carlos Roberto Ribeiro de
.













ABSTRACT Objective: To examine the physical function and respiratory muscle strength of patients - who recovered from critical COVID-19 – after intensive care unit discharge to the ward on Days one (D1) and seven (D7), and to investigate variables associated with functional impairment. Methods: This was a prospective cohort study of adult patients with COVID-19 who needed invasive mechanical ventilation, non-invasive ventilation or high-flow nasal cannula and were discharged from the intensive care unit to the ward. Participants were submitted to Medical Research Council sum-score, handgrip strength, maximal inspiratory pressure, maximal expiratory pressure, and short physical performance battery tests. Participants were grouped into two groups according to their need for invasive ventilation: the Invasive Mechanical Ventilation Group (IMV Group) and the Non-Invasive Mechanical Ventilation Group (Non-IMV Group). Results: Patients in the IMV Group (n = 31) were younger and had higher Sequential Organ Failure Assessment scores than those in the Non-IMV Group (n = 33). The short physical performance battery scores (range 0 - 12) on D1 and D7 were 6.1 ± 4.3 and 7.3 ± 3.8, respectively for the Non-Invasive Mechanical Ventilation Group, and 1.3 ± 2.5 and 2.6 ± 3.7, respectively for the IMV Group. The prevalence of intensive care unit-acquired weakness on D7 was 13% for the Non-IMV Group and 72% for the IMV Group. The maximal inspiratory pressure, maximal expiratory pressure, and handgrip strength increased on D7 in both groups, but the maximal expiratory pressure and handgrip strength were still weak. Only maximal inspiratory pressure was recovered (i.e., > 80% of the predicted value) in the Non-IMV Group. Female sex, and the need and duration of invasive mechanical were independently and negatively associated with the short physical performance battery score and handgrip strength. Conclusion: Patients who recovered from critical COVID-19 and who received invasive mechanical ventilation presented greater disability than those who were not invasively ventilated. However, they both showed marginal functional improvement during early recovery, regardless of the need for invasive mechanical ventilation. This might highlight the severity of disability caused by SARS-CoV-2. Objective COVID19 COVID 19 COVID-1 D (D1 D7, , (D7) impairment Methods noninvasive non highflow high flow sumscore, sumscore sum score, sum-score tests NonInvasive Non NonIMV . Results n 31 33. 33 33) range 12 61 6 1 6. 43 4 3 4. 73 7 7. 38 8 3.8 13 1. 25 2 5 2. 26 37 3.7 unitacquired acquired 72 weak i.e., ie i e (i.e. 80 value sex Conclusion ventilated However recovery SARSCoV2. SARSCoV2 SARSCoV SARS CoV SARS-CoV-2 COVID1 COVID- (D (D7 3. i.e. (i.e SARS-CoV- i.e SARS-CoV
RESUMO Objetivo: Examinar a função física e a força muscular respiratória de pacientes que se recuperaram da COVID-19 grave após a alta da unidade de terapia intensiva para a enfermaria nos Dias 1 e 7 e investigar as variáveis associadas ao comprometimento funcional. Métodos: Trata-se de estudo de coorte prospectivo de pacientes adultos com COVID-19 que necessitaram de ventilação mecânica invasiva, ventilação mecânica não invasiva ou cânula nasal de alto fluxo e tiveram alta da unidade de terapia intensiva para a enfermaria. Os participantes foram submetidos aos testes Medical Research Council sum-score, força de preensão manual, pressão inspiratória máxima, pressão expiratória máxima e short physical performance battery. Os participantes foram agrupados em dois grupos conforme a necessidade de ventilação mecânica invasiva: o Grupo Ventilação Mecânica Invasiva (Grupo VMI) e o Grupo Não Ventilação Mecânica Invasiva (Grupo Não VMI). Resultados: Os pacientes do Grupo VMI (n = 31) eram mais jovens e tinham pontuações do Sequential Organ Failure Assessment mais altas do que os do Grupo VMI (n = 33). As pontuações do short physical performance battery (intervalo de zero a 12) nos Dias 1 e 7 foram 6,1 ± 4,3 e 7,3 ± 3,8, respectivamente para o Grupo Não VMI, e 1,3 ± 2,5 e 2,6 ± 3,7, respectivamente para o Grupo VMI. A prevalência de fraqueza adquirida na unidade de terapia intensiva no Dia 7 foi de 13% para o Grupo Não VMI e de 72% para o Grupo VMI. A pressão inspiratória máxima, a pressão expiratória máxima e a força de preensão manual aumentaram no Dia 7 em ambos os grupos, porém a pressão expiratória máxima e a força de preensão manual ainda eram fracas. Apenas a pressão inspiratória máxima foi recuperada (ou seja, > 80% do valor previsto) no Grupo Não VMI. As variáveis sexo feminino, e necessidade e duração da ventilação mecânica invasiva foram associadas de forma independente e negativa à pontuação do short physical performance battery e à força de preensão manual. Conclusão: Os pacientes que se recuperaram da COVID-19 grave e receberam ventilação mecânica invasiva apresentaram maior incapacidade do que aqueles que não foram ventilados invasivamente. No entanto, os dois grupos de pacientes apresentaram melhora funcional marginal durante a fase inicial de recuperação, independentemente da necessidade de ventilação mecânica invasiva. Esse resultado pode evidenciar a gravidade da incapacidade causada pelo SARS-CoV-2. Objetivo COVID19 COVID 19 COVID-1 Métodos Tratase Trata sumscore, sumscore sum score, score sum-score . Resultados n 31 33. 33 33) intervalo 12 61 6 6, 43 4 3 4, 73 7, 38 8 3,8 13 1, 25 2 5 2, 26 37 3,7 72 fracas seja 80 previsto feminino Conclusão invasivamente entanto recuperação SARSCoV2. SARSCoV2 SARSCoV SARS CoV 2. SARS-CoV-2 COVID1 COVID- 3, SARS-CoV- SARS-CoV
11.
Catálogo Taxonômico da Fauna do Brasil: Setting the baseline knowledge on the animal diversity in Brazil Brasil
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Boeger, Walter A.
; Valim, Michel P.
; Zaher, Hussam
; Rafael, José A.
; Forzza, Rafaela C.
; Percequillo, Alexandre R.
; Serejo, Cristiana S.
; Garraffoni, André R.S.
; Santos, Adalberto J.
Slipinski, Adam
Linzmeier, Adelita M.
Calor, Adolfo R.
Garda, Adrian A.
Kury, Adriano B.
Fernandes, Agatha C.S.
Agudo-Padrón, Aisur I.
Akama, Alberto
Silva Neto, Alberto M. da
Burbano, Alejandro L.
Menezes, Aleksandra
Pereira-Colavite, Alessandre
Anichtchenko, Alexander
Lees, Alexander C.
Bezerra, Alexandra M.R.
Domahovski, Alexandre C.
Pimenta, Alexandre D.
Aleixo, Alexandre L.P.
Marceniuk, Alexandre P.
Paula, Alexandre S. de
Somavilla, Alexandre
Specht, Alexandre
Camargo, Alexssandro
Newton, Alfred F.
Silva, Aline A.S. da
Santos, Aline B. dos
Tassi, Aline D.
Aragão, Allan C.
Santos, Allan P.M.
Migotto, Alvaro E.
Mendes, Amanda C.
Cunha, Amanda
Chagas Júnior, Amazonas
Sousa, Ana A.T. de
Pavan, Ana C.
Almeida, Ana C.S.
Peronti, Ana L.B.G.
Henriques-Oliveira, Ana L.
Prudente, Ana L.
Tourinho, Ana L.
Pes, Ana M.O.
Carmignotto, Ana P.
Wengrat, Ana P.G. da Silva
Dornellas, Ana P.S.
Molin, Anamaria Dal
Puker, Anderson
Morandini, André C.
Ferreira, André da S.
Martins, André L.
Esteves, André M.
Fernandes, André S.
Roza, André S.
Köhler, Andreas
Paladini, Andressa
Andrade, Andrey J. de
Pinto, Ângelo P.
Salles, Anna C. de A.
Gondim, Anne I.
Amaral, Antonia C.Z.
Rondón, Antonio A.A.
Brescovit, Antonio
Lofego, Antônio C.
Marques, Antonio C.
Macedo, Antonio
Andriolo, Artur
Henriques, Augusto L.
Ferreira Júnior, Augusto L.
Lima, Aurino F. de
Barros, Ávyla R. de A.
Brito, Ayrton do R.
Romera, Bárbara L.V.
Vasconcelos, Beatriz M.C. de
Frable, Benjamin W.
Santos, Bernardo F.
Ferraz, Bernardo R.
Rosa, Brunno B.
Sampaio, Brunno H.L.
Bellini, Bruno C.
Clarkson, Bruno
Oliveira, Bruno G. de
Corrêa, Caio C.D.
Martins, Caleb C.
Castro-Guedes, Camila F. de
Souto, Camilla
Bicho, Carla de L.
Cunha, Carlo M.
Barboza, Carlos A. de M.
Lucena, Carlos A.S. de
Barreto, Carlos
Santana, Carlos D.C.M. de
Agne, Carlos E.Q.
Mielke, Carlos G.C.
Caetano, Carlos H.S.
Flechtmann, Carlos H.W.
Lamas, Carlos J.E.
Rocha, Carlos
Mascarenhas, Carolina S.
Margaría, Cecilia B.
Waichert, Cecilia
Digiani, Celina
Haddad, Célio F.B.
Azevedo, Celso O.
Benetti, Cesar J.
Santos, Charles M.D. dos
Bartlett, Charles R.
Bonvicino, Cibele
Ribeiro-Costa, Cibele S.
Santos, Cinthya S.G.
Justino, Cíntia E.L.
Canedo, Clarissa
Bonecker, Claudia C.
Santos, Cláudia P.
Carvalho, Claudio J.B. de
Gonçalves, Clayton C.
Galvão, Cleber
Costa, Cleide
Oliveira, Cléo D.C. de
Schwertner, Cristiano F.
Andrade, Cristiano L.
Pereira, Cristiano M.
Sampaio, Cristiano
Dias, Cristina de O.
Lucena, Daercio A. de A.
Manfio, Daiara
Amorim, Dalton de S.
Queiroz, Dalva L. de
Queiroz, Dalva L. de
Colpani, Daniara
Abbate, Daniel
Aquino, Daniel A.
Burckhardt, Daniel
Cavallari, Daniel C.
Prado, Daniel de C. Schelesky
Praciano, Daniel L.
Basílio, Daniel S.
Bená, Daniela de C.
Toledo, Daniela G.P. de
Takiya, Daniela M.
Fernandes, Daniell R.R.
Ament, Danilo C.
Cordeiro, Danilo P.
Silva, Darliane E.
Pollock, Darren A.
Muniz, David B.
Gibson, David I.
Nogueira, David S.
Marques, Dayse W.A.
Lucatelli, Débora
Garcia, Deivys M.A.
Baêta, Délio
Ferreira, Denise N.M.
Rueda-Ramírez, Diana
Fachin, Diego A.
Souza, Diego de S.
Rodrigues, Diego F.
Pádua, Diego G. de
Barbosa, Diego N.
Dolibaina, Diego R.
Amaral, Diogo C.
Chandler, Donald S.
Maccagnan, Douglas H.B.
Caron, Edilson
Carvalho, Edrielly
Adriano, Edson A.
Abreu Júnior, Edson F. de
Pereira, Edson H.L.
Viegas, Eduarda F.G.
Carneiro, Eduardo
Colley, Eduardo
Eizirik, Eduardo
Santos, Eduardo F. dos
Shimbori, Eduardo M.
Suárez-Morales, Eduardo
Arruda, Eliane P. de
Chiquito, Elisandra A.
Lima, Élison F.B.
Castro, Elizeu B. de
Orlandin, Elton
Nascimento, Elynton A. do
Razzolini, Emanuel
Gama, Emanuel R.R.
Araujo, Enilma M. de
Nishiyama, Eric Y.
Spiessberger, Erich L.
Santos, Érika C.L. dos
Contreras, Eugenia F.
Galati, Eunice A.B.
Oliveira Junior, Evaldo C. de
Gallardo, Fabiana
Hernandes, Fabio A.
Lansac-Tôha, Fábio A.
Pitombo, Fabio B.
Dario, Fabio Di
Santos, Fábio L. dos
Mauro, Fabio
Nascimento, Fabio O. do
Olmos, Fabio
Amaral, Fabio R.
Schunck, Fabio
Godoi, Fábio S. P. de
Machado, Fabrizio M.
Barbo, Fausto E.
Agrain, Federico A.
Ribeiro, Felipe B.
Moreira, Felipe F.F.
Barbosa, Felipe F.
Silva, Fenanda S.
Cavalcanti, Fernanda F.
Straube, Fernando C.
Carbayo, Fernando
Carvalho Filho, Fernando
Zanella, Fernando C.V.
Jacinavicius, Fernando de C.
Farache, Fernando H.A.
Leivas, Fernando
Dias, Fernando M.S.
Mantellato, Fernando
Vaz-de-Mello, Fernando Z.
Gudin, Filipe M.
Albuquerque, Flávio
Molina, Flavio B.
Passos, Flávio D.
Shockley, Floyd W.
Pinheiro, Francielly F.
Mello, Francisco de A.G. de
Nascimento, Francisco E. de L.
Franco, Francisco L.
Oliveira, Francisco L. de
Melo, Francisco T. de V.
Quijano, Freddy R.B.
Salles, Frederico F.
Biffi, Gabriel
Queiroz, Gabriel C.
Bizarro, Gabriel L.
Hrycyna, Gabriela
Leviski, Gabriela
Powell, Gareth S.
Santos, Geane B. dos
Morse, Geoffrey E.
Brown, George
Mattox, George M.T.
Zimbrão, Geraldo
Carvalho, Gervásio S.
Miranda, Gil F.G.
Moraes, Gilberto J. de
Lourido, Gilcélia M.
Neves, Gilmar P.
Moreira, Gilson R.P.
Montingelli, Giovanna G.
Maurício, Giovanni N.
Marconato, Gláucia
Lopez, Guilherme E.L.
Silva, Guilherme L. da
Muricy, Guilherme
Brito, Guilherme R.R.
Garbino, Guilherme S.T.
Flores, Gustavo E.
Graciolli, Gustavo
Libardi, Gustavo S.
Proctor, Heather C.
Gil-Santana, Helcio R.
Varella, Henrique R.
Escalona, Hermes E.
Schmitz, Hermes J.
Rodrigues, Higor D.D.
Galvão Filho, Hilton de C.
Quintino, Hingrid Y.S.
Pinto, Hudson A.
Rainho, Hugo L.
Miyahira, Igor C.
Gonçalves, Igor de S.
Martins, Inês X.
Cardoso, Irene A.
Oliveira, Ismael B. de
Franz, Ismael
Fernandes, Itanna O.
Golfetti, Ivan F.
S. Campos-Filho, Ivanklin
Oliveira, Ivo de S.
Delabie, Jacques H.C.
Oliveira, Jader de
Prando, Jadila S.
Patton, James L.
Bitencourt, Jamille de A.
Silva, Janaina M.
Santos, Jandir C.
Arruda, Janine O.
Valderrama, Jefferson S.
Dalapicolla, Jeronymo
Oliveira, Jéssica P.
Hájek, Jiri
Morselli, João P.
Narita, João P.
Martin, João P.I.
Grazia, Jocélia
McHugh, Joe
Cherem, Jorge J.
Farias Júnior, José A.S.
Fernandes, Jose A.M.
Pacheco, José F.
Birindelli, José L.O.
Rezende, José M.
Avendaño, Jose M.
Duarte, José M. Barbanti
Ribeiro, José R. Inácio
Mermudes, José R.M.
Pujol-Luz, José R.
Santos, Josenilson R. dos
Câmara, Josenir T.
Teixeira, Joyce A.
Prado, Joyce R. do
Botero, Juan P.
Almeida, Julia C.
Kohler, Julia
Gonçalves, Julia P.
Beneti, Julia S.
Donahue, Julian P.
Alvim, Juliana
Almeida, Juliana C.
Segadilha, Juliana L.
Wingert, Juliana M.
Barbosa, Julianna F.
Ferrer, Juliano
Santos, Juliano F. dos
Kuabara, Kamila M.D.
Nascimento, Karine B.
Schoeninger, Karine
Campião, Karla M.
Soares, Karla
Zilch, Kássia
Barão, Kim R.
Teixeira, Larissa
Sousa, Laura D. do N.M. de
Dumas, Leandro L.
Vieira, Leandro M.
Azevedo, Leonardo H.G.
Carvalho, Leonardo S.
Souza, Leonardo S. de
Rocha, Leonardo S.G.
Bernardi, Leopoldo F.O.
Vieira, Letícia M.
Johann, Liana
Salvatierra, Lidianne
Oliveira, Livia de M.
Loureiro, Lourdes M.A. El-moor
Barreto, Luana B.
Barros, Luana M.
Lecci, Lucas
Camargos, Lucas M. de
Lima, Lucas R.C.
Almeida, Lucia M.
Martins, Luciana R.
Marinoni, Luciane
Moura, Luciano de A.
Lima, Luciano
Naka, Luciano N.
Miranda, Lucília S.
Salik, Lucy M.
Bezerra, Luis E.A.
Silveira, Luis F.
Campos, Luiz A.
Castro, Luiz A.S. de
Pinho, Luiz C.
Silveira, Luiz F.L.
Iniesta, Luiz F.M.
Tencatt, Luiz F.C.
Simone, Luiz R.L.
Malabarba, Luiz R.
Cruz, Luiza S. da
Sekerka, Lukas
Barros, Lurdiana D.
Santos, Luziany Q.
Skoracki, Maciej
Correia, Maira A.
Uchoa, Manoel A.
Andrade, Manuella F.G.
Hermes, Marcel G.
Miranda, Marcel S.
Araújo, Marcel S. de
Monné, Marcela L.
Labruna, Marcelo B.
Santis, Marcelo D. de
Duarte, Marcelo
Knoff, Marcelo
Nogueira, Marcelo
Britto, Marcelo R. de
Melo, Marcelo R.S. de
Carvalho, Marcelo R. de
Tavares, Marcelo T.
Kitahara, Marcelo V.
Justo, Marcia C.N.
Botelho, Marcia J.C.
Couri, Márcia S.
Borges-Martins, Márcio
Felix, Márcio
Oliveira, Marcio L. de
Bologna, Marco A.
Gottschalk, Marco S.
Tavares, Marcos D.S.
Lhano, Marcos G.
Bevilaqua, Marcus
Santos, Marcus T.T.
Domingues, Marcus V.
Sallum, Maria A.M.
Digiani, María C.
Santarém, Maria C.A.
Nascimento, Maria C. do
Becerril, María de los A.M.
Santos, Maria E.A. dos
Passos, Maria I. da S. dos
Felippe-Bauer, Maria L.
Cherman, Mariana A.
Terossi, Mariana
Bartz, Marie L.C.
Barbosa, Marina F. de C.
Loeb, Marina V.
Cohn-Haft, Mario
Cupello, Mario
Martins, Marlúcia B.
Christofersen, Martin L.
Bento, Matheus
Rocha, Matheus dos S.
Martins, Maurício L.
Segura, Melissa O.
Cardenas, Melissa Q.
Duarte, Mércia E.
Ivie, Michael A.
Mincarone, Michael M.
Borges, Michela
Monné, Miguel A.
Casagrande, Mirna M.
Fernandez, Monica A.
Piovesan, Mônica
Menezes, Naércio A.
Benaim, Natalia P.
Reategui, Natália S.
Pedro, Natan C.
Pecly, Nathalia H.
Ferreira Júnior, Nelson
Silva Júnior, Nelson J. da
Perioto, Nelson W.
Hamada, Neusa
Degallier, Nicolas
Chao, Ning L.
Ferla, Noeli J.
Mielke, Olaf H.H.
Evangelista, Olivia
Shibatta, Oscar A.
Oliveira, Otto M.P.
Albornoz, Pablo C.L.
Dellapé, Pablo M.
Gonçalves, Pablo R.
Shimabukuro, Paloma H.F.
Grossi, Paschoal
Rodrigues, Patrícia E. da S.
Lima, Patricia O.V.
Velazco, Paul
Santos, Paula B. dos
Araújo, Paula B.
Silva, Paula K.R.
Riccardi, Paula R.
Garcia, Paulo C. de A.
Passos, Paulo G.H.
Corgosinho, Paulo H.C.
Lucinda, Paulo
Costa, Paulo M.S.
Alves, Paulo P.
Roth, Paulo R. de O.
Coelho, Paulo R.S.
Duarte, Paulo R.M.
Carvalho, Pedro F. de
Gnaspini, Pedro
Souza-Dias, Pedro G.B.
Linardi, Pedro M.
Bartholomay, Pedro R.
Demite, Peterson R.
Bulirsch, Petr
Boll, Piter K.
Pereira, Rachel M.M.
Silva, Rafael A.P.F.
Moura, Rafael B. de
Boldrini, Rafael
Silva, Rafaela A. da
Falaschi, Rafaela L.
Cordeiro, Ralf T.S.
Mello, Ramon J.C.L.
Singer, Randal A.
Querino, Ranyse B.
Heleodoro, Raphael A.
Castilho, Raphael de C.
Constantino, Reginaldo
Guedes, Reinaldo C.
Carrenho, Renan
Gomes, Renata S.
Gregorin, Renato
Machado, Renato J.P.
Bérnils, Renato S.
Capellari, Renato S.
Silva, Ricardo B.
Kawada, Ricardo
Dias, Ricardo M.
Siewert, Ricardo
Brugnera, Ricaro
Leschen, Richard A.B.
Constantin, Robert
Robbins, Robert
Pinto, Roberta R.
Reis, Roberto E. dos
Ramos, Robson T. da C.
Cavichioli, Rodney R.
Barros, Rodolfo C. de
Caires, Rodrigo A.
Salvador, Rodrigo B.
Marques, Rodrigo C.
Araújo, Rodrigo C.
Araujo, Rodrigo de O.
Dios, Rodrigo de V.P.
Johnsson, Rodrigo
Feitosa, Rodrigo M.
Hutchings, Roger W.
Lara, Rogéria I.R.
Rossi, Rogério V.
Gerstmeier, Roland
Ochoa, Ronald
Hutchings, Rosa S.G.
Ale-Rocha, Rosaly
Rocha, Rosana M. da
Tidon, Rosana
Brito, Rosangela
Pellens, Roseli
Santos, Sabrina R. dos
Santos, Sandra D. dos
Paiva, Sandra V.
Santos, Sandro
Oliveira, Sarah S. de
Costa, Sávio C.
Gardner, Scott L.
Leal, Sebastián A. Muñoz
Aloquio, Sergio
Bonecker, Sergio L.C.
Bueno, Sergio L. de S.
Almeida, Sérgio M. de
Stampar, Sérgio N.
Andena, Sérgio R.
Posso, Sergio R.
Lima, Sheila P.
Gadelha, Sian de S.
Thiengo, Silvana C.
Cohen, Simone C.
Brandão, Simone N.
Rosa, Simone P.
Ribeiro, Síria L.B.
Letana, Sócrates D.
Santos, Sonia B. dos
Andrade, Sonia C.S.
Dávila, Stephane
Vaz, Stéphanie
Peck, Stewart B.
Christo, Susete W.
Cunha, Suzan B.Z.
Gomes, Suzete R.
Duarte, Tácio
Madeira-Ott, Taís
Marques, Taísa
Roell, Talita
Lima, Tarcilla C. de
Sepulveda, Tatiana A.
Maria, Tatiana F.
Ruschel, Tatiana P.
Rodrigues, Thaiana
Marinho, Thais A.
Almeida, Thaís M. de
Miranda, Thaís P.
Freitas, Thales R.O.
Pereira, Thalles P.L.
Zacca, Thamara
Pacheco, Thaynara L.
Martins, Thiago F.
Alvarenga, Thiago M.
Carvalho, Thiago R. de
Polizei, Thiago T.S.
McElrath, Thomas C.
Henry, Thomas
Pikart, Tiago G.
Porto, Tiago J.
Krolow, Tiago K.
Carvalho, Tiago P.
Lotufo, Tito M. da C.
Caramaschi, Ulisses
Pinheiro, Ulisses dos S.
Pardiñas, Ulyses F.J.
Maia, Valéria C.
Tavares, Valeria
Costa, Valmir A.
Amaral, Vanessa S. do
Silva, Vera C.
Wolff, Vera R. dos S.
Slobodian, Verônica
Silva, Vinícius B. da
Espíndola, Vinicius C.
Costa-Silva, Vinicius da
Bertaco, Vinicius de A.
Padula, Vinícius
Ferreira, Vinicius S.
Silva, Vitor C.P. da
Piacentini, Vítor de Q.
Sandoval-Gómez, Vivian E.
Trevine, Vivian
Sousa, Viviane R.
Sant’Anna, Vivianne B. de
Mathis, Wayne N.
Souza, Wesley de O.
Colombo, Wesley D.
Tomaszewska, Wioletta
Wosiacki, Wolmar B.
Ovando, Ximena M.C.
Leite, Yuri L.R.








ABSTRACT The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others. publications problem uptodate up date classifications context exception (CTFB http//fauna.jbrj.gov.br/, httpfaunajbrjgovbr http //fauna.jbrj.gov.br/ , jbrj gov br (http://fauna.jbrj.gov.br/) 2015 Brazil 80 specialists 1 2024 133691 133 691 133,69 125138 125 138 125,13 82.3%, 823 82 3 (82.3% 102000 102 000 102,00 7.69%, 769 7 69 (7.69% 11000 11 11,00 . 3,567 3567 567 (3,56 2,292 2292 2 292 (2,29 1,833 1833 833 (1,83 1,447 1447 447 (1,44 1000 1,00 831 (83 628 (62 606 (60 520 (52 50 users science health biology law anthropology education others http//fauna.jbrj.gov.br/ faunajbrjgovbr //fauna.jbrj.gov.br (http://fauna.jbrj.gov.br/ 201 8 202 13369 13 133,6 12513 12 125,1 82.3% (82.3 10200 10 00 102,0 7.69% 76 6 (7.69 1100 11,0 3,56 356 56 (3,5 2,29 229 29 (2,2 1,83 183 83 (1,8 1,44 144 44 (1,4 100 1,0 (8 62 (6 60 52 (5 5 http//fauna.jbrj.gov.br (http://fauna.jbrj.gov.br 20 1336 133, 1251 125, 82.3 (82. 1020 0 102, 7.69 (7.6 110 11, 3,5 35 (3, 2,2 22 (2, 1,8 18 (1, 1,4 14 4 ( 82. (82 7.6 (7. 3, (3 2, (2 (1 7. (7
12.
Adaptation, testing, and use of the "iSupport for Dementia" program in different countries: a systematic review Adaptation testing iSupport Dementia countries
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Corrêa, Larissa
; Gratão, Aline Cristina Martins
; Oliveira, Déborah
; Barham, Elizabeth Joan
; Orlandi, Fabiana de Souza
; Cruz, Keila Cristianne Trindade da
; Ottaviani, Ana Carolina
; Monteiro, Diana Quirino
; Barbosa, Gustavo Carrijo
; Pilegis, Anabel Machado Cardoso Alvarenga
; Rocha, Luana Aparecida da
; Alves, Ludmyla Caroline de Souza
; Maciel, Luiza Barros
; Campos, Camila Rafael Ferreira
; Pavarini, Sofia Cristina Iost
.















ABSTRACT The World Health Organization developed the "iSupport for Dementia" program for family caregivers of people with dementia. Objective: To explore studies on adaptation, randomized clinical trial protocols, and preliminary results of iSupport by unpaid caregivers of people living with dementia in different countries. Methods: Systematic review. Results: Ten cultural adaptation studies, eight randomized clinical trial protocols, and two preliminary results were included. Adaptation studies showed adjustments in terminology, design, and additional resources. Clinical trial protocols included burden as the primary outcome, and baseline, three months of intervention, and follow-up after six months. Studies with preliminary results found positive effects on the mental health and well-being of caregivers after using the program. Conclusion: iSupport is an online program of the World Health Organization in response to dementia in implementation in different countries. Dementia Objective countries Methods review Results terminology design resources outcome baseline intervention followup follow up wellbeing well being Conclusion
RESUMO A Organização Mundial da Saúde desenvolveu o programa "iSupport for Dementia" para cuidadores familiares de pessoas com demência. Objetivo: Explorar estudos sobre adaptação, protocolos de ensaio clínico randomizado e resultados preliminares do "iSupport" por cuidadores não remunerados de pessoas que vivem com demência em diferentes países. Métodos: Revisão sistemática. Resultados: Foram incluídos dez estudos de adaptação cultural, oito protocolos de Ensaio Clínico Randomizado e dois resultados preliminares. Os estudos de adaptação apresentaram os ajustes nas terminologias, design e recursos adicionais. Os protocolos de ensaio clínico incluíram a sobrecarga como desfecho primário, e com linha de base, três meses de intervenção e acompanhamento após seis meses. Os estudos com resultados preliminares encontraram efeitos positivos na saúde mental e bem-estar dos cuidadores após o uso do programa. Conclusão: O iSupport é um programa online da Organização Mundial da Saúde em resposta à demência na implantação em diferentes países. Dementia Objetivo países Métodos sistemática Resultados cultural terminologias adicionais primário base bemestar bem estar Conclusão
13.
Safety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer ChAdOx SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- arthritis SARS-CoV
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Cruz, Vitor Alves
; Guimarães, Camila
Rêgo, Jozelia
Machado, Ketty Lysie Libardi Lira
Miyamoto, Samira Tatiyama
Burian, Ana Paula Neves
Dias, Laiza Hombre
Pretti, Flavia Zon
Batista, Danielle Cristina Filgueira Alves
Mill, José Geraldo
Oliveira, Yasmin Gurtler Pinheiro de
Gadelha, Carolina Strauss Estevez
Gouveia, Maria da Penha Gomes
Moulin, Anna Carolina Simões
Souza, Bárbara Oliveira
Aguiar, Laura Gonçalves Rodrigues
Vieira, Gabriel Smith Sobral
Grillo, Luiza Lorenzoni
Lima, Marina Deorce de
Pasti, Laís Pizzol
Surlo, Heitor Filipe
Faé, Filipe
Moulaz, Isac Ribeiro
Macabú, Mariana de Oliveira
Ribeiro, Priscila Dias Cardoso
Magalhães, Vanessa de Oliveira
Aguiar, Mariana Freitas de
Biegelmeyer, Erika
Peixoto;, Flávia Maria Matos Melo Campos
Kayser, Cristiane
Souza, Alexandre Wagner Silva de
Castro, Charlles Heldan de Moura
Ribeiro, Sandra Lúcia Euzébio
Telles, Camila Maria Paiva França
Bühring, Juliana
Lima, Raquel Lima de
Santos, Sérgio Henrique Oliveira Dos
Dias, Samuel Elias Basualto
Melo, Natália Seixas de
Sanches, Rosely Holanda da Silva
Boechat, Antonio Luiz
Sartori, Natália Sarzi
Hax, Vanessa
Dória, Lucas Denardi
Rezende, Rodrigo Poubel Vieira de
Baptista, Katia Lino
Fortes, Natália Rodrigues Querido
Melo, Ana Karla Guedes de
Melo, Tâmara Santos
Vieira, Rejane Maria Rodrigues de Abreu
Vieira, Adah Sophia Rodrigues
Kakehasi, Adriana Maria
Tavares, Anna Carolina Faria Moreira Gomes
Landa, Aline Teixeira de
Costa, Pollyana Vitoria Thomaz da
Azevedo, Valderilio Feijó
Martins-Filho, Olindo Assis
Peruhype-Magalhães, Vanessa
Pinheiro, Marcelo de Medeiros
Monticielo, Odirlei André
Reis-neto, Edgard Torres Dos
Ferreira, Gilda Aparecida
Souza, Viviane Angelina de
Teixeira-Carvalho, Andréa
Xavier, Ricardo Machado
Sato, Emilia Inoue
Valim, Valeria
Pileggi, Gecilmara Salviato
Silva, Nilzio Antonio da

Abstract Background Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA. Objective To evaluate the safety of vaccines against SARS-CoV-2 in patients with RA. Methods This data are from the study “Safety and Efficacy on COVID-19 Vaccine in Rheumatic Diseases,” a Brazilian multicentric prospective phase IV study to evaluate COVID-19 vaccine in IMRDs in Brazil. Adverse events (AEs) in patients with RA of all centers were assessed after two doses of ChAdOx1 (Oxford/AstraZeneca) or CoronaVac (Sinovac/Butantan). Stratification of postvaccination AEs was performed using a diary, filled out daily and returned at the end of 28 days for each dose. Results A total of 188 patients with RA were include, 90% female. CoronaVac was used in 109 patients and ChAdOx1 in 79. Only mild AEs were observed, mainly after the first dose. The most common AEs after the first dose were pain at the injection (46,7%), headache (39,4%), arthralgia (39,4%), myalgia (30,5%) and fatigue (26,6%), and ChAdOx1 had a higher frequency of pain at the injection (66% vs 32 %, p < 0.001) arthralgia (62% vs 22%, p < 0.001) and myalgia (45% vs 20%, p < 0.001) compared to CoronaVac. The more common AEs after the second dose were pain at the injection (37%), arthralgia (31%), myalgia (23%), headache (21%) and fatigue (18%). Arthralgia (41,4% vs 25%, p = 0.02) and pain at injection (51,4% vs 27%, p = 0.001) were more common with ChAdOx1. No serious AEs were related. With Regard to RA activity level, no significant difference was observed between the three time periods for both COVID-19 vaccines. Conclusion In the comparison between the two immunizers in patients with RA, local reactions and musculoskeletal symptoms were more frequent with ChAdOx1 than with CoronaVac, especially after the first dose. In summary, the AE occurred mainly after the first dose, and were mild, like previous data from others immunizing agents in patients with rheumatoid arthritis. Vaccination did not worsen the degree of disease activity. immunemediated immune mediated (IMRDs COVID19 COVID 19 COVID-1 risks (RA outcomes comorbidities However SARSCoV2 SARSCoV SARS CoV 2 SARS-CoV- Safety Diseases, Diseases Brazil (AEs ChAdOx Oxford/AstraZeneca OxfordAstraZeneca Oxford AstraZeneca (Oxford/AstraZeneca Sinovac/Butantan. SinovacButantan Sinovac/Butantan . Sinovac Butantan (Sinovac/Butantan) diary 18 include 90 female 10 79 46,7%, 467 46,7% , 46 7 (46,7%) 39,4%, 394 39,4% 39 4 (39,4%) 30,5% 305 30 5 (30,5% 26,6%, 266 26,6% 26 6 (26,6%) 66% 66 (66 3 % 0.001 0001 0 001 62% 62 (62 22 22% 45% 45 (45 20 20% 37%, 37 37% (37%) 31%, 31 31% (31%) 23%, 23 23% (23%) 21% 21 (21% 18%. 18% (18%) 41,4% 414 41 (41,4 25 25% 0.02 002 02 51,4% 514 51 (51,4 27 27% related level summary COVID1 1 COVID- SARS-CoV (Sinovac/Butantan 9 46,7 (46,7% 39,4 (39,4% 30,5 (30,5 26,6 (26,6% (6 0.00 000 00 (4 (37% (31% (23% (21 (18% 41,4 (41, 0.0 51,4 (51, 46, (46,7 39, (39,4 30, (30, 26, (26,6 ( (37 (31 (23 (2 (18 41, (41 0. 51, (51 (46, (39, (30 (26, (3 (1 (5 (46 (39 (26
14.
Click-evoked auditory brainstem response: The influence of age and risk factors for hearing loss Clickevoked Click evoked response
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Rocha, Josiana
; Resende, Luciana Macedo de
; Rezende, Ana Luiza de Freitas
; Valadares, Ana Carolina Andrade
; Ferreira, Daniella Bregunce Fernandes
; Carvalho, Sirley Alves da Silva
.






ABSTRACT Purpose: to analyze the relationship between infants’ auditory brainstem response results and their corrected gestational age, considering prematurity and risk factors for hearing loss. Methods: a cross-sectional, observational study with 62 infants, divided into G1 (27 to 36 weeks) and G2 (37 to 41 weeks). After normal NHS results, the click-evoked ABR investigated the integrity of the auditory pathways and the electrophysiological threshold. Data were analyzed using descriptive statistics, as well as the association with the Mann-Whitney test and the correlation between electrophysiological threshold and corrected gestational age using the Spearman’s test with a significance level of 5%. Results: neither group had statistically significant different absolute latency values and interpeak intervals in the auditory pathway integrity study. The electrophysiological threshold study found a statistically significant difference between G1 and G2. Likewise, the difference between the electrophysiological threshold and the presence of risk factors for hearing loss and between the electrophysiological threshold and prematurity was statically significant. The electrophysiological threshold was weakly correlated with the corrected gestational age. Conclusion: the corrected gestational age in the study population did not influence the absolute latency parameters and interpeak intervals. However, the electrophysiological threshold was better in the group whose corrected gestational age was 37 or more weeks. Moreover, the presence of risk factors for hearing loss helped increase the electrophysiological threshold. Purpose infants Methods crosssectional, crosssectional cross sectional, sectional cross-sectional 6 G 27 (2 3 weeks (3 4 . clickevoked click evoked statistics MannWhitney Mann Whitney Spearmans Spearman s 5 5% Results Likewise Conclusion However Moreover 2 (
RESUMO Objetivo: analisar a relação entre os resultados dos Potenciais Evocados Auditivos de Tronco Encefálico e a idade gestacional corrigida de lactentes, considerando prematuridade e Indicadores de Risco para Deficiência Auditiva (IRDA). Métodos: estudo observacional transversal, composto por 62 lactentes, divididos em: G1 - 27 a 36 semanas e G2 - 37 a 41 semanas. Após resultado normal na TAN, foi realizado o PEATE por clique para pesquisa de integridade das vias auditivas e de limiar eletrofisiológico. Os dados foram analisados por meio de estatística descritiva, de associação amparada pelo teste Mann-Whitney e de correlação entre limiar eletrofisiológico e idade gestacional corrigida por meio do teste Spearman. O nível de significância adotado foi de 5% e intervalos de confiança de 95%. Resultados: os dois grupos apresentaram valores de latências absolutas e intervalos interpicos sem diferença estatisticamente significante na pesquisa de integridade de vias auditivas. Na pesquisa de limiar eletrofisiológico, foi observada diferença com relevância estatística entre G1 e G2. Na relação entre limiar eletrofisiológico e presença de IRDA e limiar eletrofisiológico com prematuridade também foi observada diferença com relevância estatística. Houve correlação fraca entre limiar eletrofisiológico e idade gestacional corrigida. Conclusão: conclui-se que, na população avaliada, os parâmetros de latência absoluta e os intervalos interpicos não foram influenciados pela idade gestacional corrigida. Entretanto, o limiar eletrofisiológico foi melhor no grupo com idade gestacional corrigida superior a 37 semanas. Pode-se também observar que a presença de indicadores de risco para a deficiência auditiva contribuiu para o aumento do limiar eletrofisiológico. Objetivo lactentes IRDA. . (IRDA) Métodos transversal 6 em G 2 3 4 TAN descritiva MannWhitney Mann Whitney Spearman 5 95 95% Resultados Conclusão concluise conclui se avaliada Entretanto Podese Pode (IRDA 9
15.
Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma XIIIa
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Flores, Isadora Luana
; de Arruda, José Alcides Almeida
; Abrantes, Thamiris de Castro
; Gamba, Thiago de Oliveira
; Abrahão, Aline Correa
; Anbinder, Ana Lia
; Ribeiro, Jaqueline Lemes
; Vasconcelos, Ana Carolina Uchoa
; Andrade, Bruno Augusto Benevenuto de
; Aguiar, Maria Cassia Ferreira de
; Gomes, Ana Paula Neutzling
; Abreu, Lucas Guimarães
; Mesquita, Ricardo Alves
.













Abstract There is an interaction between dendrocytes and mast cells in the skin. However, in elastosis-related diseases such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), this interaction remains unknown. We investigated the presence of intact and degranulated mast cells in AC and LLSCC. Associations of mast cells with factor XIIIa+ dendrocytes and inflammatory infiltrate were assessed. Forty cases of AC (20 with low-grade and 20 with high-grade epithelial dysplasia), 50 cases of LLSCC, and 10 cases of normal oral mucosa were evaluated. Toluidine blue staining was performed to identify mast cells, and mast cell densities were calculated in the inflammatory infiltrate. Factor XIIIa+ dendrocytes were immunohistochemically quantified. The highest ratio of intact/degranulated mast cells density was detected in LLSCC (5.9 cells/mm2), followed by AC with high-grade epithelial dysplasia (4.8 cells/mm2). Statistically significant differences were found in the density of intact mast cells compared to degranulated mast cells in AC with low-grade epithelial dysplasia (p<0.001), AC with high-grade epithelial dysplasia (p=0.005), and LLSCC (p<0.001). A positive correlation between degranulated mast cells and total inflammatory infiltrate (p=0.03) was observed in the LLSCC group. The expression of factor XIIIa+ dendrocytes was highest in AC with low-grade epithelial dysplasia (16.5 cells/mm2). The link between mast cell density, factor XIIIa+ dendrocytes, and inflammatory infiltrate indicates a potential crosstalk in lip carcinogenesis. skin However elastosisrelated elastosis related (AC , (LLSCC) unknown XIIIa assessed (2 lowgrade low grade 2 highgrade high dysplasia, dysplasia) 5 1 evaluated quantified intactdegranulated 5.9 59 9 (5. cells/mm2, cellsmm2 cellsmm cells/mm2 mm2 mm cells/mm2) 4.8 48 4 8 (4. cells/mm2. . p<0.001, p0001 p p<0.001 0 001 (p<0.001) p=0.005, p0005 p=0.005 005 (p=0.005) p<0.001. p=0.03 p003 03 (p=0.03 group 16.5 165 16 (16. carcinogenesis (LLSCC ( 5. (5 cells/mm 4. (4 p000 p<0.00 00 (p<0.001 p=0.00 (p=0.005 p=0.0 p00 (p=0.0 16. (16 p<0.0 (p<0.00 (p=0.00 p=0. p0 (p=0. (1 p<0. (p<0.0 p=0 (p=0 p<0 (p<0. p= (p= p< (p<0 (p (p<
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