Pesquisa | SciELO

Abstract Objective Evaluate autonomic function and low-grade inflammation and characterize the correlation between these variables in schoolchildren with obesity living in the Brazilian northeast region. Methods 84 children with obesity and 41 with normal weight were included in this cross-sectional study. Anthropometry, body composition, blood pressure (BP), inflammatory biomarkers, and heart rate variability (HRV) indexes were analyzed in children aged 7 to 11 years. Results children with obesity had increased systolic (p= 0.0017) and diastolic (p= 0.0131) BP and heart rate (p= 0.0022). The children with obesity displayed significantly lower SDNN, RMSSD, NN50, HF (ms), HF (nu), SD1, SD2, and higher LF (ms), LF (nu), LF/HF, SD1/SD2, DFA-α1, and DFA-α2, compared to normal weight. A lower and higher capacity for producing IL-10 (p= 0.039) and IL-2 (p= 0.009), respectively, were found in children with obesity compared to children with normal weight. Although IL-2, IL-4 and IL17A did not correlate with HRV parameters, IL-6 was positively correlated with SDNN, LF (ms) and SD2, TNF-α was positively correlated with LF/HF and SD1/SD2 ratio, and IFN-γ was positively correlated with SDNN, RMMSSD, NN50, LF (ms), HF (ms), SD1, and SD2. Conclusions The findings suggest that children with obesity have impaired autonomic function and systemic low-grade inflammation compared to children within the normal weight range, the inflammatory biomarkers were correlated with HRV parameters in schoolchildren living in the northeastern region of Brazil. lowgrade low grade 8 4 crosssectional cross sectional study Anthropometry composition BP, , (BP) (HRV 1 years p= p (p 0.0017 00017 0 0017 0.0131 00131 0131 0.0022. 00022 0.0022 . 0022 0.0022) SDNN RMSSD NN50 NN ms, ms nu, nu (nu) SD1 SD SD2 LFHF SD1SD2 SDSD DFAα1, DFAα1 DFAα DFA α1, α1 α DFA-α1 DFAα2, DFAα2 α2, α2 DFA-α2 IL10 IL 10 IL-1 0.039 0039 039 IL2 2 IL- 0.009, 0009 0.009 009 0.009) respectively IL2, 2, IL4 ILA IL6 6 (ms TNFα TNF SD1/SD ratio IFNγ IFN γ RMMSSD range Brazil (BP 0.001 0001 001 0.013 0013 013 0002 0.002 002 NN5 (nu SD1SD DFA-α IL1 0.03 003 03 000 0.00 00 0.01 01 0.0 0.

https://doi.org/10.1016/j.jped.2023.07.003

Vaccination coverage, barriers and vaccine hesitancy in children up to 24 months old: a population survey in a state capital in the Western Amazon coverage 2 old
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Macedo, Thaiane Rodrigues de Oliveira

; Borges, Maria Fernanda de Sousa Oliveira

; Silva, Ilce Ferreira da

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 Nº spe2 elocation e20231295

Resumo: En Pt Es | Texto: En Pt Es | PDF: En | PDF: Pt | PDF: Es

ABSTRACT Objective To estimate vaccination coverage, identify barriers and hesitancy to vaccinating children up to 24 months, born between 2017-2018, living in the urban area of Rio Branco, Acre, Brazil. Methods Population survey carried out from 2020 to 2021, which assessed sociodemographic characteristics and vaccination status among children. Results Among 451 included children, vaccination coverage was below 80%. Meningococcal C vaccine had the lowest coverage for administered doses (76.3%; 95%CI 70.5;81.3) and doses on time (27.4%; 95%CI 23.1;32.1). The statements “vaccines cause serious adverse reactions” (26.4%; 95%CI 18.1;36.8) and “you don’t need vaccination for diseases that no longer exist” (22%; 95%CI 15.7;29.8) were the most frequent regarding vaccination hesitancy. Lack of vaccines was the main barrier to care (86.6%; 95%CI 71.8;94.3). Conclusion Vaccination coverage in children born in 2017-2018 was below the target recommended for the full schedule of administered doses, both valid and timely administered. 2 months 20172018, 20172018 2017 2018, 2018 Branco Acre Brazil 202 2021 45 80 80% 76.3% 763 76 3 (76.3% 95CI CI 95 70.581.3 705813 70.5 81.3 70 5 81 70.5;81.3 27.4% 274 27 4 (27.4% 23.132.1. 231321 23.1 32.1 . 23 1 32 23.1;32.1) reactions 26.4% 264 26 (26.4% 18.136.8 181368 18.1 36.8 18 36 8 18.1;36.8 you dont don t exist 22% 22 (22% 15.729.8 157298 15.7 29.8 15 7 29 15.7;29.8 86.6% 866 86 6 (86.6% 71.894.3. 718943 71.8 94.3 71 94 71.8;94.3) 2017-201 2017201 201 20 76.3 (76.3 9 581 70.581. 70581 705 70. 813 81. 70.5;81. 27.4 (27.4 132 23.132.1 23132 231 23. 321 32. 23.1;32.1 26.4 (26.4 136 18.136. 18136 181 18. 368 36. 18.1;36. (22 729 15.729. 15729 157 15. 298 29. 15.7;29. 86.6 (86.6 894 71.894.3 71894 718 71. 943 94. 71.8;94.3 2017-20 201720 76. (76. 58 70.581 7058 70.5;81 27. (27. 13 23.132. 2313 23.1;32. 26. (26. 18.136 1813 18.1;36 (2 72 15.729 1572 15.7;29 86. (86. 89 71.894. 7189 71.8;94. 2017-2 20172 (76 70.58 70.5;8 (27 23.132 23.1;32 (26 18.13 18.1;3 ( 15.72 15.7;2 (86 71.894 71.8;94 2017- (7 70.5; 23.13 23.1;3 18.1; 15.7; (8 71.89 71.8;9 23.1; 71.8;

RESUMO Objetivo Estimar a cobertura vacinal, identificar barreiras e hesitação à vacinação em crianças com até 24 meses, nascidas em 2017 e 2018, residentes na área urbana de Rio Branco-AC. Métodos Inquérito populacional realizado de 2020 a 2021, que avaliou as características sociodemográficas e a situação vacinal em crianças nascidas entre 2017 e 2018. Resultados Entre as 451 crianças estudadas, as coberturas vacinais foram inferiores a 80%. A menor cobertura para doses aplicadas (76,3%; IC95% 70,5;81,3) e oportunas (27,4%; IC95% 23,1;32,1) foi para o reforço da meningocócica C. As afirmações “vacinas causam reações adversas graves” (26,4%; IC95% 18,1;36,8) e “não precisa da vacina para doenças que não existem mais” (22%; IC95% 15,7;29,8) foram as mais frequentes quanto à hesitação vacinal. A falta da vacina foi a principal barreira assistencial (86,6%; IC95% 71,8;94,3). Conclusão As coberturas vacinais em crianças nascidas em 2017 e 2018 ficaram abaixo da meta preconizada nos esquemas completos de doses aplicadas, válidas e oportunas. 2 meses 201 BrancoAC. BrancoAC Branco AC. AC Branco-AC 202 2021 45 estudadas 80 80% 76,3% 763 76 3 (76,3% IC95 IC 70,581,3 705813 70,5 81,3 70 5 81 70,5;81,3 27,4% 274 27 4 (27,4% 23,132,1 231321 23,1 32,1 23 1 32 23,1;32,1 C vacinas graves 26,4% 264 26 (26,4% 18,136,8 181368 18,1 36,8 18 36 8 18,1;36,8 22% 22 (22% 15,729,8 157298 15,7 29,8 15 7 29 15,7;29,8 86,6% 866 86 6 (86,6% 71,894,3. 718943 71,8 94,3 . 71 94 71,8;94,3) 20 76,3 (76,3 IC9 581 70,581, 70581 705 70, 813 81, 70,5;81, 27,4 (27,4 132 23,132, 23132 231 23, 321 32, 23,1;32, 26,4 (26,4 136 18,136, 18136 181 18, 368 36, 18,1;36, (22 729 15,729, 15729 157 15, 298 29, 15,7;29, 86,6 (86,6 894 71,894,3 71894 718 71, 943 94, 9 71,8;94,3 76, (76, 58 70,581 7058 70,5;81 27, (27, 13 23,132 2313 23,1;32 26, (26, 18,136 1813 18,1;36 (2 72 15,729 1572 15,7;29 86, (86, 89 71,894, 7189 71,8;94, (76 70,58 70,5;8 (27 23,13 23,1;3 (26 18,13 18,1;3 ( 15,72 15,7;2 (86 71,894 71,8;94 (7 70,5; 23,1; 18,1; 15,7; (8 71,89 71,8;9 71,8;

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231295.especial2.en

Vaccination coverage, hesitancy and associated factors: a household survey of a cohort of children born in 2017 and 2018 in urban areas of state capital cities in the Brazilian Northeast coverage factors 201 20 2
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Saavedra, Ramon da Costa

; Santiago, Martha Suely Itaparica de Carvalho

; Teixeira, Maria da Glória Lima Cruz

; Antunes, Maria Bernadete de Cerqueira

; Queiroz, Rejane Christine de Sousa

; Lima, Luisa Helena de Oliveira

; Ramos Jr, Alberto Novaes

; Ferreira, Anderson Fuentes

; Maciel, Adjoane Mauricio Silva

; Barbosa, Jaqueline Caracas

; França, Ana Paula

; Domingues, Carla Magda Allan Santos

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Glória Lima Cruz

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 Nº spe2 elocation e20231298

Resumo: En Pt Es | Texto: En Pt Es | PDF: En | PDF: Pt | PDF: Es

ABSTRACT Objective To estimate vaccination coverage and analyze sociodemographic factors associated with non-vaccination in children born in 2017 and 2018 in the state capitals of Northeast Brazil. Methods A household survey using cluster sampling was conducted from 2020-2022 to estimate vaccination coverage and hesitancy. Factors associated with non-vaccination were analyzed using logistic regression to calculate Odds Ratios (OR) and their Confidence Intervals (95%CI). Results Natal was the capital with the lowest vaccination coverage, below 75.0% for most immunizers. Teresina had rates equal to or greater than 90.0% for all vaccines. Among those interviewed, 99.1% (95%CI 98.9;99.3) believe that vaccines are important for health; 95.4% (95%CI 95.0;95.8) trust immunobiologicals and 79.6% (95%CI% 78.8;80.3) are not afraid of reactions. Belonging to the highest socioeconomic stratum (adjusted OR: 1.34 – 95%CI 1.20;1.50) was as a factor associated with non-vaccination. Conclusion Low coverage highlights the need for a better understanding of regional specificities and social inequalities. nonvaccination non 201 Brazil 20202022 2020 2022 2020-202 hesitancy OR (OR 95%CI. 95CI CI . 95 (95%CI) 750 75 0 75.0 immunizers 900 90 90.0 interviewed 991 99 1 99.1 98.999.3 989993 98.9 99.3 98 9 3 98.9;99.3 health 954 4 95.4 95.095.8 950958 95.0 95.8 8 95.0;95.8 796 79 6 79.6 95%CI% 78.880.3 788803 78.8 80.3 78 80 78.8;80.3 reactions adjusted 134 34 1.3 1.201.50 120150 1.20 1.50 20 50 1.20;1.50 nonvaccination. vaccination. inequalities 2020202 202 2020-20 7 75. 90. 99. 999 98.999. 98999 989 98. 993 98.9;99. 95. 095 95.095. 95095 950 958 95.0;95. 79. 880 78.880. 78880 788 78. 803 80. 78.8;80. 13 1. 1.201.5 12015 120 1.2 150 1.5 2 5 1.20;1.5 202020 2020-2 98.999 9899 98.9;99 09 95.095 9509 95.0;95 88 78.880 7888 78.8;80 1.201. 1201 12 15 1.20;1. 20202 2020- 98.99 98.9;9 95.09 95.0;9 78.88 78.8;8 1.201 1.20;1 98.9; 95.0; 78.8; 1.20;

RESUMO Objetivo Estimar a cobertura vacinal e analisar fatores sociodemográficos associados à não vacinação em crianças nascidas vivas em 2017 e 2018 nas capitais do Nordeste brasileiro. Métodos Realizou-se inquérito domiciliar com amostragem por conglomerados, entre 2020 e 2022, para estimar cobertura e hesitação vacinal. Fatores associados à não vacinação foram analisados usando-se regressão logística para calcular odds ratio (OR) e seus intervalos de confiança (IC95%). Resultados A capital com menores coberturas vacinais foi Natal, com < 75,0% para a maioria dos imunizantes; Teresina apresentou coberturas ≥ 90,0% em todos os imunizantes. Dos entrevistados, 99,1% (IC95% 98,9;99,3) acreditavam que vacinas são importantes para a saúde; 95,4% (IC95% 95,0;95,8) confiavam nos imunobiológicos distribuídos pelo governo; e 79,6% (IC95% 78,8;80,3) não tinham medo de reações adversas. Residir em estrato socioeconômico mais alto (OR ajustado: 1,34 – IC95% 1,20;1,50) foi fator associado à não vacinação. Conclusão As baixas coberturas destacam a necessidade de entender melhor as especificidades regionais e as desigualdades sociais. 201 brasileiro Realizouse Realizou se conglomerados 202 2022 usandose usando OR IC95%. IC95 IC . (IC95%) Natal 750 75 0 75,0 imunizantes 900 90 90,0 entrevistados 991 99 1 99,1 (IC95 98,999,3 989993 98,9 99,3 98 9 3 98,9;99,3 saúde 954 95 4 95,4 95,095,8 950958 95,0 95,8 8 95,0;95,8 governo 796 79 6 79,6 78,880,3 788803 78,8 80,3 78 80 78,8;80,3 adversas ajustado 134 34 1,3 1,201,50 120150 1,20 1,50 20 50 1,20;1,50 sociais IC9 7 75, 90, 99, (IC9 999 98,999, 98999 989 98, 993 98,9;99, 95, 095 95,095, 95095 950 958 95,0;95, 79, 880 78,880, 78880 788 78, 803 80, 78,8;80, 13 1, 1,201,5 12015 120 1,2 150 1,5 2 5 1,20;1,5 (IC 98,999 9899 98,9;99 09 95,095 9509 95,0;95 88 78,880 7888 78,8;80 1,201, 1201 12 15 1,20;1, 98,99 98,9;9 95,09 95,0;9 78,88 78,8;8 1,201 1,20;1 98,9; 95,0; 78,8; 1,20;

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231298.especial2.en

Vaccination coverage, hesitancy and associated factors: a household survey of a cohort of children born in 2017 and 2018 in urban areas of state capital cities in the Brazilian Northeast
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Saavedra, Ramon da Costa

; Santiago, Martha Suely Itaparica de Carvalho

; Teixeira, Maria da Glória Lima Cruz

; Antunes, Maria Bernadete de Cerqueira

; Queiroz, Rejane Christine de Sousa

; Lima, Luisa Helena de Oliveira

; Ramos Jr, Alberto Novaes

; Ferreira, Anderson Fuentes

; Maciel, Adjoane Mauricio Silva

; Barbosa, Jaqueline Caracas

; França, Ana Paula

; Domingues, Carla Magda Allan Santos

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Glória Lima Cruz

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 Nº spe2 elocation e20231298

Resumo: En Pt Es | Texto: En Pt Es | PDF: En | PDF: Pt | PDF: Es

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231298.especial2.en

Vaccination coverage, barriers and vaccine hesitancy in children up to 24 months old: a population survey in a state capital in the Western Amazon
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Macedo, Thaiane Rodrigues de Oliveira

; Borges, Maria Fernanda de Sousa Oliveira

; Silva, Ilce Ferreira da

; França, Ana Paula

; Moraes, José Cássio de

; Silva, Adriana Ilha da

; Ramos Jr., Alberto Novaes

; França, Ana Paula

; Oliveira, Andrea de Nazaré Marvão

; Boing, Antonio Fernando

; Domingues, Carla Magda Allan Santos

; Oliveira, Consuelo Silva de

; Maciel, Ethel Leonor Noia

; Guibu, Ione Aquemi

; Mirabal, Isabelle Ribeiro Barbosa

; Barbosa, Jaqueline Caracas

; Lima, Jaqueline Costa

; Moraes, José Cássio de

; Luhm, Karin Regina

; Caetano, Karlla Antonieta Amorim

; Lima, Luisa Helena de Oliveira

; Antunes, Maria Bernadete de Cerqueira

; Teixeira, Maria da Gloria

; Teixeira, Maria Denise de Castro

; Borges, Maria Fernanda de Sousa Oliveira

; Queiroz, Rejane Christine de Sousa

; Gurgel, Ricardo Queiroz

; Barata, Rita Barradas

; Azevedo, Roberta Nogueira Calandrini de

; Oliveira, Sandra Maria do Valle Leone de

; Teles, Sheila Araújo

; Gama, Silvana Granado Nogueira da

; Mengue, Sotero Serrate

; Simões, Taynãna César

; Nascimento, Valdir

; Araújo, Wildo Navegantes de

Epidemiologia e Serviços de Saúde

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2024, Volume 33 Nº spe2 elocation e20231295

Resumo: En Pt Es | Texto: En Pt Es | PDF: En | PDF: Pt | PDF: Es

resumen está disponible en el texto completo

https://doi.org/10.1590/s2237-96222024v33e20231295.especial2.en

Copaiba oleoresin presents anti-obesogenic effect and mitigates inflammation and redox imbalance in adipose tissue
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TELLES, Luciana Ortega

; SILVA, Bianca Sulzbacher da

; PAULINO, Angélica Macedo Borges

; MENDONÇA, Sabrina Trigueiro

; SINHORIN, Valéria Dornelles Gindri

; LIMA, Milena Campelo Freitas de

; VEIGA JUNIOR, Valdir Florêncio

; ANDRIGHETTI, Carla Regina

; NASCIMENTO, André Ferreira do

; BOMFIM, Gisele Facholi

; LUVIZOTTO, Renata Azevedo Melo

Acta Amazonica

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Dez 2022, Volume 52 Nº 4 Páginas 331 - 338

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

RESUMO Obesidade leva ao acúmulo de gordura e disfunção do tecido adiposo. Compostos ativos foram descritos no óleo-resina de copaíba, que apresenta efeitos anti-inflamatórios, antimicrobiais e antioxidantes. Contudo, não há dados sobre os efeitos do óleo-resina de copaíba sobre o tecido adiposo. Assim, testamos a hipótese de que o óleo-resina de copaíba pode prevenir ou minimizar a obesidade, e inflamação e estresse oxidativo no tecido adiposo em resposta à dieta rica em sacarose. Ratos Wistar machos foram casualmente divididos para receber dieta padrão (C, n = 8), dieta padrão e 30% de sacarose na água de beber (S, n = 8), e dieta padrão e 30% de sacarose na água de beber + óleo-resina de copaíba (S+CO, n = 8). O óleo-resina de copaíba foi administrado via gavagem (200 mg kg-1 dia-1), por oito semanas. Animais dos grupos não suplementados (C e S) receberam veículo via gavagem, em volume equivalente ao oferecido ao grupo S+CO. Ao final do experimento, amostras de sangue e tecido adiposo epididimal foram coletadas para análises bioquímicas, inflamatórias e de estresse oxidativo. A suplementação com óleo-resina preveniu ganho de peso, adiposidade, resistência à insulina e aumento de IL-1β, inibiu parcialmente o aumento nos níveis de glicemia de jejum, lipídeos e níveis de IL-6 no tecido adiposo, além de melhorar o sistema de defesa antioxidante no tecido. Nossos resultados sugerem que o óleo-resina de copaíba pode ser usado como uma boa estratégia para a prevenção da obesidade e suas complicações.

ABSTRACT Obesogenic diets lead to fat accumulation and dysfunctional adipose tissue. Active compounds were described in copaiba oleoresin, which presents anti-inflammatory, antimicrobial, and antioxidant properties. However, there are no data regarding the effects of copaiba oleoresin in adipose tissue. Therefore, we tested the hypothesis that the copaiba oleoresin could prevent or minimize obesity and adipose tissue inflammation and oxidative stress in response to a high sucrose diet. Male Wistar rats were randomly assigned to receiving commercial chow (C, n = 8), commercial chow and 30% sucrose added to the drinking water (S, n = 8), or commercial chow and 30% sucrose added to the drinking water + copaiba oleoresin (S+CO, n = 8). Copaiba oleoresin was given at a dose of 200 mg kg-1 day-1 by gavage for eight weeks. C and S animals received vehicle, at equivalent volume, by gavage. At the end of the experiment, blood samples and epididymal adipose tissue were collected for biochemical, inflammatory, and oxidative stress analyses. Copaiba oleoresin supplementation prevented weight gain, adiposity, insulin resistance, and increased IL-1β levels. Additionally, copaiba oleoresin partially attenuated the increase in fasting glucose levels, lipids, and IL-6 levels, and improved the redox status in adipose tissue. Our results suggest that the use of copaiba oleoresin could be a good strategy for prevention of obesity and its complications.

https://doi.org/10.1590/1809-4392202201411

Natural and Semisynthetic Triterpenes from Combretum leprosum Mart. with Antiplasmodial Activity
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Passarini, Guilherme M.

; Ferreira, Amália S.

; Moreira-Dill, Leandro S.

; Zanchi, Fernando B.

; Jesus, Aurileya G. de

; Facundo, Valdir A.

; Teles, Carolina B. G.

Journal of the Brazilian Chemical Society

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Mai 2022, Volume 33 Nº 5 Páginas 483 - 490

Resumo: En | Texto: En | PDF: En

Malaria is responsible for thousands of deaths each year. Currently, artemisinin combination therapy (ACT) is used as first-choice medication against the disease. However, the emergence of resistant strains prompts the search for alternative compounds. The present study aimed to investigate the antiplasmodial activities of natural triterpenes (compounds 1 and 2), and semisynthetic derivatives 1a, 1b, 1c, and 1d. Antiplasmodial assays were carried out using the SYBR Green technique, whereas cytotoxicity was evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. Hemolytic assays were performed on human erythrocytes. An in silico analysis of the compounds against PfENR (Plasmodium falciparum 2-trans-enoyl-reductase) was carried out by molecular docking. Experiments with 1, and its derivatives against P. falciparum showed that 1a was very similar in terms of biological activity to compound 1 (half maximal inhibitory concentration (IC50) ca. 4 µM), whereas 1b, 1c, and 1d had reduced antiplasmodial activities (IC50 between 8-103 µM). The selectivity indexes of 1 and 1d for HepG2, and Vero cells were > 10. Docking results partially agreed with the in vitro experiments, with 1 and 1c having the best and worst affinities with PfENR, respectively. In conclusion, the results showed that 1 and 1d may serve as biotechnological tools in the development of antimalarial drugs.

https://doi.org/10.21577/0103-5053.20210167

Spinal anesthesia for elective cesarean section. Bupivacaine associated with different doses of fentanyl: randomized clinical trial
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Ferrarezi, Wesla Packer Pfeifer

; Braga, Angélica de Fátima de Assunção

; Ferreira, Valdir Batista

; Mendes, Sara Quinta

; Brandão, Maria José Nascimento

; Braga, Franklin Sarmento da Silva

; Carvalho, Vanessa Henriques

Brazilian Journal of Anesthesiology

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Dez 2021, Volume 71 Nº 6 Páginas 642 - 648

Resumo: En | Texto: En | PDF: En

Abstract Objective Assess patients submitted to elective cesarean section under spinal anesthesia, and the efficacy of different doses of fentanyl associated with bupivacaine. Methods The study included 124 pregnant women randomly distributed into 4 groups (n = 31) according to different doses of fentanyl (15 µg, 10 µg, 7.5 µg), Groups I, II, and III, respectively, and control group IV, associated with 0.5% hyperbaric bupivacaine (10 mg). An epidural catheter was inserted in case epidural top-up was required. We assessed the anesthetic blockage characteristics, negative maternal and neonatal outcomes, and maternal side effects. Statistical analysis was performed using Kruskal-Wallis, Fisher’s exact and chi-square tests. The level of significance was 5% (p< 0.05). Results The quality of analgesia, time for the first complaint of pain and motor block recovery time were significantly better for groups that received fentanyl in comparison to controls (p< 0.001). None of the groups had negative maternal-fetal outcomes. Nausea was significantly more frequent in patients in Groups II (10 µg) and III (7.5 µg) when compared to Groups I (15 µg) and IV (no fentanyl). Vomiting was more frequent in Group III than in Group I (p= 0.006). The incidence of pruritus was significantly higher in the groups receiving fentanyl (p= 0.012). Conclusions Among the solutions studied, the spinal anesthesia technique using 15 µg of fentanyl associated with 10 mg of hyperbaric bupivacaine provided satisfactory analgesia and very low incidence of adverse effects for patients submitted to cesarean section. Trial Registration Number UTN U1111-1199-0285. REBEC RBR-5XWT6T.

https://doi.org/10.1016/j.bjane.2021.03.030

Analysis of the Clinical and Radiological Results of Bridge Plate Versus External Fixation in Comminuted Distal Radius Fractures
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Carula, Beatriz Canhoto

; Pereira, Matheus da Silva

; Ferreira, Ana Paula Bonilauri

; Ayzemberg, Henrique

; Steglich, Valdir

; Stangarlin, Tiago Salati

Revista Brasileira de Ortopedia

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Fev 2021, Volume 56 Nº 1 Páginas 61 - 68

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Objetivo Avaliar e comparar os resultados clínicos e radiológicos de pacientes com fraturas cominutivas distais do rádio tratados com fixador externo ou placa ponte dorsal. Métodos Foram analisados 45 pacientes, sendo 18 tratados com fixador externo, e 25, com placa ponte dorsal, após 1 ano de pós-operatório. Aplicou-se uma escala analógica de dor e o questionário Disabilities of the Arm, Shouder and Hand (DASH), além de análise radiográfica, da avaliação de força, e da amplitude de movimento. As análises estatísticas foram realizadas utilizando o teste qui-quadrado e o teste não paramétrico de Mann-Whitney. Resultados A fratura foi mais comum em mulheres acima de 60 anos por queda do mesmo nível. Ambos os métodos demonstraram resultados funcional e radiológico similares. A infecção foi mais prevalente com o uso do fixador externo, mas a força de preensão residual foi melhor. Neuropatia simpático-reflexa foi mais comum com o uso da placa ponte dorsal. Conclusão Não houve consenso da superioridade de um método em relação ao outro em nossa análise. Cada um dos métodos apresenta vantagens e desvantagens, mas ambos mostraram resultados bons e semelhantes. A escolha do tratamento deve ser atribuída ao perfil do trauma, às condições clínicas do paciente, à experiência do profissional, e à disponibilidade de materiais.

Abstract Objective To evaluate and compare the clinical and radiological outcomes of patients with comminuted distal radius fractures treated with an external fixator or a dorsal bridge plate. Methods In total, 45 patients were analyzed 1 year after surgery; 18 were treated with an external fixator, and 25 received a dorsal bridge plate. An analog pain scale and the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire were applied, in addition to radiographic, strength and range of motion assessments. Statistical analyzes were performed using the chi-squared test and the Mann-Whitney non-parametric test. Results Fractures were more common in women over 60 years old who suffered falls from their own height. Both methods demonstrated similar functional and radiological results. Infections were more prevalent in patients receiving external fixators, but their residual grip strength was better. Reflex sympathetic neuropathy was more common in subjects treated with a dorsal bridge plate. Conclusion Our analysis showed no consensus on the superiority of one method over the other. Each method had advantages and disadvantages, but both led to good, similar outcomes. The treatment must be chosen according to the profile of the trauma, the patient's clinical conditions, the surgeon's experience, and the availability of materials.

https://doi.org/10.1055/s-0040-1713393 318 downloads

10.

Reemergence of human malaria in Atlantic Forest of Rio Grande do Sul, Brazil
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de Lemos, Alessandra Bittencourt

; da Silva, Onilda Santos

; Deboni, Sandra Cristina

; Schallemberger, Valdir

; dos Santos, Edmilson

; de Almeida, Marco Antônio Barreto

; Marth, Anne Andrea Dockhorn

; Silva, Sidnei

; Mello, Aline Rosa de Lavigne

; Silva-do-Nascimento, Teresa Fernandes

; Ferreira-da-Cruz, Maria de Fátima

; Lourenço-de-Oliveira, Ricardo

; Cardoso, Jáder da Cruz

Memórias do Instituto Oswaldo Cruz

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2021, Volume 116 elocation e210064

Resumo: En | Texto: En | PDF: En

Unforeseen Plasmodium infections in the Atlantic Forest of Brazilian Extra-Amazonian region could jeopardise malaria elimination. A human malaria case was registered in Três Forquilhas, in the Atlantic Forest biome of Rio Grande do Sul, after a 45 years’ time-lapsed without any malaria autochthonous notification in this southern Brazilian state. This finding represents the expansion of the malaria distribution areas in Brazil and the southernmost human malaria case record in South America in this decade. The coexistence of the bromeliad-breeding vector Anopheles (Kerteszia) cruzii and non-human primates in the Atlantic Forest regularly visited by the patient claimed for the zoonotic origin of this infection. The reemergence of Atlantic Forest human malaria in Rio Grande do Sul was also discussed.

https://doi.org/10.1590/0074-02760210064 124 downloads

11.

Enzymatic association in the diets of laying hens raised in an alternative cage-free system
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Silva, Valquíria Sousa

; Rodrigues, Kênia Ferreira

; Krabbe, Everton Luis

; Vaz, Roberta Gomes Marçal Vieira

; Ávila, Valdir Silveira de

; Contreira, Cristiele Lange

Pesquisa Agropecuária Brasileira

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2021, Volume 56 elocation e02275

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo: O objetivo deste trabalho foi avaliar o uso de associações enzimáticas em rações, com diferentes matrizes nutricionais, para poedeiras criadas em sistema “cage-free” alternativo. O experimento foi realizado com 800 poedeiras Isa Brown de 24-30 semanas de idade, distribuídas em arranjo fatorial 2x2, com duas associações de enzimas (fitase e xilanase) e duas matrizes nutricionais (convencional e supervalorizada). Os tratamentos foram: T1, fitase (450 FTU por kilogram) + xilanase (12.000 BXU por kilogram), com uso da matriz I (100 Kcal kg-1 de energia metabolizável aparente, 0,16% de cálcio, 0,15% de fósforo disponível, 0,03% de sódio e 0,02% de lisina digestível); T2, fitase (1.500 FTU por kilogram) e matriz I; T3, fitase (450 FTU por kilogram) + xilanase (12.000 BXU por kilogram), com uso da matriz II (120 Kcal kg-1 de energia metabolizável aparente, 0,22% de cálcio, 0,20% de fósforo disponível, 0,04 de sódio e 0,05% de lisina digestível); e T4, fitase (1.500 FTU por kilogram) e matriz II. Foram analisadas variáveis de desempenho produtivo e qualidade externa e interna dos ovos. O uso de fitase ou da associação fitase + xilanase, independentemente da matriz nutricional utilizada, conseguiu atender às exigências nutricionais dos animais e manter o seu desempenho produtivo. Porém, a combinação fitase + xilanase e a adoção da matriz I foi mais eficiente.

Abstract: The objective of this work was to evaluate the use of enzyme combinations in diets, with different nutritional uplift matrices, for hens raised in an alternative cage-free system. The experiment was carried out with 800 Isa Brown laying hens aged 24-30 weeks, distributed in a 2x2 factorial arrangement, with two combinations of enzymes (phytase and xylanase) and two nutritional matrices (conventional and overvalued uplifts). The treatments were: T1, phytase (450 FTU per kilogram) + xylanase (12,000 BXU per kilogram), using matrix I (100 Kcal kg-1 apparent metabolizable energy, 0.16% calcium, 0.15% available phosphorus, 0.03 sodium, and 0.02% digestible lysine); T2, phytase (1,500 FTU per kilogram) and matrix I; T3, phytase (450 FTU per kilogram) + xylanase (12,000 BXU per kilogram), using matrix II (120 Kcal kg-1 apparent metabolizable energy, 0.22% calcium, 0.20% available phosphorus, 0.04% sodium, and 0.05% digestible lysine); and T4, phytase (1,500 FTU per kilogram) and matrix II. Productive performance variables and external and internal egg quality were analyzed. The use of phytase or of the phytase + xylanase combination, independently of the nutritional matrix used, met the nutrient requirements of the animals and maintained their productive performance. However, the combination phytase + xylanase and the adoption of matrix I was more efficient.

https://doi.org/10.1590/s1678-3921.pab2021.v56.02275 204 downloads

12.

The selective obtaining of amyrins from Amazonian Protium oleoresins
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Gomes da Silva Ferreira, Rosilene

; Guühon-Simplicio, Fernanda

; de Lima Yamaguchi, Klenicy Kazumy

; Duarte de Lira, Priscila

; Marques Machado, Tallita

; Couto Ferreira, Márcio Antônio

; da Veiga-Junior, Valdir Florêncio

; Silva Lima, Emerson

Revista Colombiana de Ciencias Químico - Farmacéuticas

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Ago 2020, Volume 49 Nº 2 Páginas 482 - 497

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN La oleorresina producida por especies del género Protium sp. es rica en amirinas alfa y beta, dos triterpenos con muchas actividades farmacológicas. Esta investigación buscó optimizar las técnicas de extracción y aislamiento de amirinas de la resina para hacer factible la obtención mejorada de esos productos. Se compararon dos métodos de extracción (maceración y sonicación) con diferentes solventes con aislamiento directo de la resina cruda. El aislamento de los triterpenos se realizó mediante columnas cromatográficas y los rendimientos de extractos y fracciones fueron hechos mediante análisis de varianza. El mejor solvente para la extracción de amirinas fue el hexano para ambos métodos de maceración y sonicación (38,16±2,06% y 37,67±8,21%, respectivamente). No hubo diferencia estadística entre estos métodos y el método directo (32,05±2,40%). Además, el método directo es más barato y ecológico. De este modo, esta investigación demostró que es posible obtener una gran cantidad de amirinas a través de métodos rápidos, baratos y ecológicos.

SUMMARY The oleoresin produced by species of genus Protium sp. is rich in alpha and betaamyrins, two triterpenes with many pharmacogical activities. Considering the need to make the improved obtainment of these products feasible, this study sought to optimize techniques for the extraction and isolation of amyrins from resin. Two methods of extraction (maceration and sonication) with different solvents were compared to direct isolation from crude resin. The isolation of triterpenes was performed by chromatographic columns and the yields of extracts and fractions were analyzed by analysis of variance. The best extraction solvent for amyrins was hexane for both maceration and sonication methods (38.16±2.06% and 37.67±8.21%, respectively). There was no statistical difference between these methods and the direct method (32.05±2.40%). Additionally, the direct method is cheaper and more environmentally friendly. Thus, this study showed that it is possible to obtain a large quantity of amyrins by means of cheap, fast and ecological methods.

https://doi.org/10.15446/rcciquifa.v49n2.89923 234 downloads

13.

Organic trace minerals and calcium levels in broilers' diets to 21 days old
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Faria, Bruno Damaceno

; Silva, Leandro Moreira

; Ribeiro Junior, Valdir

; Ferreira, Adriana Helena do Nascimento

; Rostagno, Horacio Santiago

; Albino, Luiz Fernando Teixeira

; Hannas, Melissa Izabel

Scientia Agricola

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2020, Volume 77 Nº 1 elocation e20180071

Resumo: En | Texto: En | PDF: En

ABSTRACT: This study was undertaken to evaluate the effects of dietary calcium levels and supplementation with organic trace minerals selenium, copper, iron, zinc and manganese on performance, tissue deposition and litter mineral concentration. A total of 2,496 one-day-old male Cobb 500 broilers were randomly assigned to a 3 × 4 factorial experimental design with three levels of dietary Ca [8, 10 and 12 g kg–1, while maintaining the same Ca:nPP (non-phytate phosphorus) ratio (2:1)] and four levels of micromineral supplementation (0.62, 0.72, 0.82 and 0.92 g kg–1). There was a total of 12 treatments, with eight replicates of 26 birds per pen. Micromineral supplementation (MS) was achieved by adding different levels of the product Bioplex TR Se® and Ca supplementation was achieved by adding increasing levels of limestone and dicalcium phosphate. An interaction between Ca and MS levels was observed (p < 0.05) for the parameters of performance, liver Cu concentration, breast Se and Cu concentrations and litter Se, Mn and Zn concentrations. No interactions were observed (p > 0.05) for Ca, P or ash concentrations in the tibia, which were influenced only by dietary Ca levels (p < 0.05). The Ca level of 10 g kg–1 promoted higher Ca and P concentration in the tibia and lower micromineral excretion in the litter. The combination of MS level of 0.82 g kg–1 with Ca level of 10 g kg–1 led to the best BWG response. The supplementation conditions that led to higher micromineral levels in the liver and breast varied for each mineral.

https://doi.org/10.1590/1678-992x-2018-0071 1860 downloads

14.

Polystyrene and cornstarch anti-corrosive coatings on steel
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Souza, Cinthia de

; Teixeira, Ricardo Luiz Perez

; Lacerda, José Carlos de

; Ferreira, Carla Regina

; Teixeira, Cynthia Helena Bouças Soares

; Signoretti, Valdir Tesch

Polímeros

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Set 2018, Volume 28 Nº 3 Páginas 226 - 230

Resumo: En | Texto: En | PDF: En

Abstract This work aims to evaluate the performance of anticorrosive thermoplastic coatings in cold rolled steel sheets. Two types of thermoplastic coatings were studied: polystyrene (PS) and cornstarch. These types of coatings are applied for protection against corrosion during transport and storage of steel plates after cold rolling until delivery to stamping or other processing. The good performance for these coatings is suitably standardized to ABNT NBR 5915-2: 2013 and ASTM A1008 / A1008M-2016. According to corrosion tests carried out in saline chamber, the coatings were satisfactory in different degrees of guarantee of corrosion protection on ASTM 1080 steel, in accordance with standards mentioned.

https://doi.org/10.1590/0104-1428.015816 1249 downloads

15.

VALOR NUTRITIVO E CARACTERÍSTICAS FERMENTATIVAS DA SILAGEM DE CAPIM-ELEFANTE COM DIFERENTES PROPORÇÕES DE CASCA DE CAFÉ
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Barcelos, Adauto Ferreira

; Carvalho, José Rodolfo Reis de

; Tavares, Valdir Botega

; Gonçalves, Clenderson Corradi de Mattos

Ciência Animal Brasileira

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2018, Volume 19 elocation e-27432

Resumo: Pt En | Texto: Pt En | PDF: Pt | PDF: En

Resumo Avaliaram-se o valor nutritivo e as características bromatológicas de silagens de capim-elefante (CE), cultivar mineiro, cortado aos 70 dias de rebrota, com adição de quatro níveis de casca de café (1-CE; 2-CE + 10%; 3-CE + 20% e 4-CE + 30%). Utilizou-se o delineamento experimental em blocos casualizados com quatro tratamentos e seis repetições. Foram determinados nas silagens os teores de lignina, celulose, cafeína, DIVMS, pH, N-NH3 e as perdas de efluente e gás. Os valores de MS aumentaram enquanto o pH reduziu linearmente com o aumento da casca de café na silagem de capim elefante. A produção de efluente ocorreu somente na silagem sem casca de café nos cinco primeiros dias, com maior produção nos três primeiros. Os valores de N-NH3 decresceram linearmente com o aumento da casca de café. Houve aumento do teor de PB à medida do aumento da casca de café. Houve aumento de FDN e redução FDA e DIVMS linear com o aumento da casca de café. Esses resultados mostram que a casca de café como aditivo foi efetivo em melhorar as características da silagem de capim-elefante cortado aos 70 dias de idade.

Abstract We evaluated the nutritional value and the bromatological characteristics of elephant grass (EG) silages, cut at 70 days of regrowth, adding four levels of coffee hulls (1-EG; 2-EG + 10%; 3-EG + 20%; and 4-EG + 30%). A randomized block design with four treatments and six replicates was used. The lignin, cellulose, caffeine, IVDDM, pH, N-NH3 and effluent and gas losses were determined in the silages. The DM values increased as pH decreased linearly with the increase of coffee hulls in EG silage. The effluent production occurred only in the silage without coffee hulls on the first five days, with higher production on the first three days. The N-NH3 values decreased linearly with the increase of the coffee hulls. There was an increase in CP content as the coffee hulls increased. There was an increase of NDF and reduction of the ADF and IVDDM linear decrease with the increase of the coffee hulls. These results show that the coffee hulls as an additive was effective in improving the characteristics of elephant grass silage cut at 70 days of age

https://doi.org/10.1590/1809-6891v19e-27432 1596 downloads

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