Resumo O objetivo foi descrever a tendência secular de mortalidade por câncer do colo do útero no Brasil e regiões de 1980 a 2021. Estudo populacional e ecológico a partir dos dados disponíveis no Departamento de Informática do Sistema Único de Saúde, por meio dos códigos 180 e C53. Taxas brutas, específicas por idade e padronizadas por idade foram calculadas pela população brasileira e mundial. A average annual percent change (AAPC) foi obtida pela análise de tendência através do Joinpoint Regression Program, com nível de significância de 0,05 e intervalos de confiança de 95% (IC95%). Ocorreram 171.793 mil mortes por câncer do colo do útero. No Brasil (AAPC -0,3; IC95% -1,0; 0,4), Norte (AAPC 0,6; IC95% -0,1; 1,3) e Sul (AAPC 0,0; IC95% -0,5; 0,5) as tendências foram estacionárias, no Nordeste (AAPC 0,6; IC95% 0,3; 0,8) foi crescente, e no Centro-Oeste (AAPC -1,3; IC95% -1,5; -1,1) e no Sudeste (AAPC -0,9; IC95% -1,4; -0,5), decrescentes. As diferenças regionais mostram que as políticas públicas precisam ser melhoradas no que concerne ao acesso das mulheres a um sistema de saúde que ofereça prevenção, rastreamento e tratamento adequados, por meio de estratégias de gestão que alcancem a população mais vulnerável.

Resumen El estudio tuvo como objetivo describir la tendencia secular de la mortalidad por cáncer de cuello uterino en Brasil y regiones de 1980 a 2021. Estudio poblacional y ecológico, realizado con datos disponibles en el Departamento de Tecnología de la Información del Sistema Único de Salud mediante los códigos 180 y C53. Se calcularon tasas brutas, tasas específicas por edad y tasas estandarizadas por edad para la población brasileña y mundial. El Cambio Porcentual Anual Promedio (CPAP) se obtuvo mediante análisis de tendencia mediante el Programa de Regresión Joinpoint, con un nivel de significancia de 0,05 e intervalos de confianza del 95% (IC 95%). Hubo 171.793 mil muertes por cáncer de cuello uterino. En Brasil (CPAP -0,3; IC95% -1,0; 0,4), Norte (CPAP 0,6; IC95% -0,1; 1,3) y Sur (CPAP 0,0; IC95% - 0,5; 0,5) las tendencias fueron estacionarias; en el Noreste (CPAP 0,6; IC95% 0,3; 0,8) fueron crecientes; y en el Centro-Oeste (CPAP -1,3; IC95% -1,5; -1,1) y Sureste (CPAP -0,9; IC95% -1,4; -0,5) fueron decrecientes. Las diferencias regionales muestran que es necesario mejorar las políticas públicas en lo que respecta al acceso de las mujeres a un sistema de salud que ofrezca una adecuada prevención, seguimiento y tratamiento mediante estrategias de gestión que lleguen a la población más vulnerable.

Abstract The scope of this study was to describe the secular trend of cervical cancer mortality in Brazil and its various regions from 1980 to 2021. It involved a populational and ecological study, based on data available at the Department of Informatics of the Unified Health System, using codes 180 and C53. Crude rates, age-specific rates, and age-standardized rates were calculated for the Brazilian and world population. The Average Annual Percent Change (AAPC) was obtained by trend analysis using the Joinpoint Regression Program, with a significance level of 0.05 and 95% confidence intervals (95%CI). There were 171,793 deaths from cervical cancer. In Brazil (AAPC -0.3; CI95%-1.0; 0.4), North (AAPC 0.6; 95%CI -0.1; 1.3) and South (AAPC 0.0; 95%CI -0.5; 0.5) the trends were stationary, increasing in the Northeast (AAPC 0.6; 95%CI 0.3; 0.8) and in the Midwest (AAPC -1.3; 95%CI -1.5; -1.1), and decreasing in the Southeast (AAPC -0.9; 95%CI -1.4; -0.5). Regional differences indicate that public policies need to be improved regarding women’s access to a health system that offers adequate prevention, screening and treatment through management strategies that include the most vulnerable population.

RESUMO CONTEXTO: A doença hepática gordura não-alcoólica caracteriza-se pela deposição de lipídios no parênquima hepático, excedendo 5% do peso do fígado na ausência de outras afecções como hepatites virais, alcoólicas ou doenças metabólicas. A doença hepática gordura não-alcoólica tem sido observada como a forma mais comum de doença hepática crônica em diversos países. Além das complicações hepáticas, estudos recentes têm demonstrado a relação entre a presença de gordura hepática e a sarcopenia. OBJETIVO: Determinar a associação entre a sarcopenia e a gravidade da esteatose hepática não-alcoólica diagnosticada pela ultrassonografia abdominal. MÉTODOS: Estudo clínico e transversal com amostra de pacientes de ambos os sexos, de 18 a 70 anos de idade, diagnosticados como portadores ou não de esteatose hepática não-alcoólica pela ultrassonografia e submetidos à avaliação da força muscular dos membros superiores e inferiores. Os dados foram inseridos no programa estatístico SPSS 22.0, analisados através do teste ANCOVA e pós-teste de Bonferroni, sendo considerado significante P<0,05. RESULTADOS: Foram avaliados pela ultrassonografia abdominal 102 pacientes e destes, 57,8% apresentaram algum grau de esteatose hepática não-alcoólica. A presença e os graus da infiltração gordurosa no fígado tiveram associação estatisticamente significativa com o índice sarcopênico, determinado pela razão entre força muscular dos membros superiores e inferiores e o IMC (P=0,009 e pós-teste P=0,028 MMSS; P=0,006 e pós-teste P=0,013 MMII). CONCLUSÃO: Observou-se associação entre o índice sarcopênico e a presença de esteatose hepática não-alcoólica, com relação inversamente proporcional entre esse índice e a gravidade da infiltração gordurosa, reforçando a interação do eixo metabólico entre fígado, tecido adiposo e músculo.

ABSTRACT BACKGROUND: Non-alcoholic fatty liver disease is characterized by deposition of lipids in the hepatic parenchyma exceeding 5% of liver weight in the absence of other conditions, such as viral or alcoholic hepatitis and metabolic disease. Non-alcoholic fatty liver disease is the most common form of chronic liver disease in several countries. In addition to liver complications, recent studies have shown a relation between liver fat and sarcopenia. OBJECTIVE: Determine the association between sarcopenia and the severity of non-alcoholic hepatic steatosis diagnosed by abdominal ultrasonography. METHODS: A clinical, cross-sectional study was conducted with a sample of male and female adults (18 to 70 years of age) submitted to ultrasonography for the investigation of non-alcoholic hepatic steatosis. Evaluations were also performed for the determination of upper and lower limb muscle strength. Data analysis was performed with the aid of the SPSS 22.0 program and involved ANCOVA and the Bonferroni post hoc test, with P-value <0.05 considered indicative of statistical significance. RESULTS: One hundred two patients were submitted to abdominal ultrasonography, 57.8% of whom presented some degree of non-alcoholic hepatic steatosis. The presence and degree of fatty liver infiltration were significantly associated with the sarcopenic index, determined by the ratio between upper and lower limb strength and BMI (P=0.009 and post-test P=0.028 for upper limbs; P=0.006 and post-test P=0.013 for lower limbs). CONCLUSION: In the present study, an association was found between the sarcopenic index and non-alcoholic hepatic steatosis, with an inversely proportional relation between this index and the severity of fatty infiltration. This finding offers further evidence of the metabolic interaction of the liver, adipose tissue and muscle.

Abstract Aim: To assess the prevalence, quality of life (QoL), and the damages caused by PH, in the professional and personal scope of Physical Education academics with Primary Hyperhidrosis (PH). Methods: A descriptive, exploratory, qualitative and quantitative cross-sectional study was carried out. Twenty-five students from the physical education course at Tiradentes University, Aracaju-SE, were interviewed from August to November 2017. Validated questionnaires were used on PH’s influence in academic activities and QoL. absolute and relative frequencies in the case of categorical variables and measures of trend and central variability in the case of numerical variables. Results: The prevalence of PH in students of Physical Education was 11.11%, mainly in combined sites, such as palmoplantar, and with no difference between the sexes. The symptoms started mostly during childhood and adolescence. Most of the interviewees (92%) reported difficulties with activities such as sports, use of personal protective equipment, handling of work equipment and instruments, and exacerbation in stress situations. They reported significant harm to QoL in situations of greeting people with handshakes, writing, wearing socks and dancing socially. Conclusion: Although PH is a disease that negatively impacts the QoL, it is still little known in the academic world with little demand for medical help. Therefore, it is necessary greater dissemination of the disease for its early diagnosis, related to the intensity of the sweating for a better therapeutic approach.