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Abstract The use of sandwich panels in construction is a viable alternative in the search for materials with low self-weight, lower thermal conductivity, and resistance to compression. To increase the sustainability of this solution, it is necessary to replace the steel reinforcement of the faces and the EPS core with materials that have lower energy costs and reduce greenhouse gas emissions during production. In this context, this study aims to develop a sandwich panel with a lightweight concrete core made from oil palm endocarp as a substitute for conventional coarse aggregate and faces with mortar reinforced with short sisal fibers. The bioconcrete was produced with two levels of oil palm endocarp (100% and 150% of the binder mass) and two water/binder ratios, 0.35 and 0.45. The increase in the content of endocarp results in increased water absorption and reduced mechanical strength, but the panels had a specific mass lower than 1480 kg/m³ and compressive strength greater than 7 MPa, qualifying them for use as infill masonry. The use of sisal fibers allowed an increase in toughness under flexure even after the initiation of panel cracking. selfweight, selfweight self weight, weight self-weight conductivity compression solution production context 100% 100 (100 150 waterbinder ratios 035 0 35 0.3 045 45 0.45 148 kgm³ kgm kg m³ m kg/m MPa masonry cracking 10 (10 15 03 3 0. 04 4 0.4 14 1 (1 (

Resumo O uso de painéis sanduíche na construção civil é uma alternativa viável na busca por materiais com baixo peso próprio, menor condutividade térmica e resistentes à compressão. Para aumentar a sustentabilidade dessa solução, é preciso substituir o reforço de aço das faces e o núcleo em EPS por materiais que apresentem menor custo energético e redução da emissão de gases do efeito estufa durante a produção. Nesse contexto, o presente trabalho tem como objetivo, desenvolver um painel sanduíche com núcleo de concreto leve feito com endocarpo do dendê em substituição do agregado graúdo convencional e faces com argamassa reforçada com fibras curtas de sisal. O bioconcreto foi produzido com dois teores de endocarpo do dendê (100% e 150% da massa de aglomerante) e duas relações água/aglomerante, de 0,35 e 0,45. O aumento do teor de endocarpo resulta em aumento da absorção de água e redução da resistência mecânica, mas os painéis apresentaram massa específica menor que 1480 kg/m³ e resistência a compressão maior que 7 MPa o que os qualifica para uso como alvenaria de vedação. O uso de fibras vegetais permitiu o aumento da tenacidade sob flexão mesmo após o início da fissuração do painel. próprio solução produção contexto objetivo sisal 100% 100 (100 150 aglomerante águaaglomerante água/aglomerante 035 0 35 0,3 045 45 0,45 mecânica 148 kgm³ kgm kg m³ m kg/m vedação 10 (10 15 03 3 0, 04 4 0,4 14 1 (1 (

https://doi.org/10.1590/s1678-86212024000100761

[SciELO Preprints] - CHOLESTEATOMA OF THE PETROSAL APEX: A RARE TUMOR
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Pykocz, Adrielle Holler Lavinsky , Joel Angeli , Roberto Dihl Roesler , Rafael Braga , Francisco Luiz Souza Santos , Ricardo Silva dos Isolan , Paola Maria Brolin Santis Nogueira, Guilherme Nobre Gonçalves , Rafaela Fernandes Isolan, Gustavo Rassier

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Data de publicação: 2024-06-06

Resumo: En Pt

Introduction: Cholesteatoma, although relatively rare, presents significant challenges in clinical practice. Despite decades of research, its cause remains complex and elusive. Objective: This review aimed to summarize key findings on the epidemiology, pathophysiology, diagnosis and surgical management of cholesteatoma, highlighting current knowledge gaps and emerging trends in the field. Method: Narrative review carried out in the PubMed and Scielo databases. The search used the following keywords: “cholesteatoma, petros apex, minimally invasive surgical procedures”. The inclusion criteria comprised review articles, pre-clinical and clinical research published, written in Portuguese and English and available in complete text. The selected articles were analyzed based on the technologies covered, future perspectives, challenges, diseases mentioned and the central idea of the article. Result: 36 articles were included. Conclusion: Cholesteatoma is important in medical practice, despite being relatively uncommon in the general population. However, there are still doubts about its cause, but its diagnosis has been expanded through imaging tests in an attempt to reduce “second-look” operations and avoid them. Another field with constant growth is surgical treatment, since the complex anatomy requires that new techniques be managed to reduce injuries to important and vital structures in the region.

Introdução: O colesteatoma, embora relativamente raro, apresenta desafios significativos na prática clínica. Apesar de décadas de pesquisa, sua causa permanece complexa e evasiva. Objetivo: Esta revisão pretendeu resumir as principais descobertas sobre a epidemiologia, fisiopatologia, diagnóstico e manejo cirúrgico do colesteatoma, destacando lacunas de conhecimento atuais e tendências emergentes no campo. Método: Revisão narrativa realizada nas bases PubMed e Scielo. A busca utilizou as seguintes palavras-chave: “colesteatoma, ápice petros, procedimentos cirúrgicos minimamente invasivos” e suas versões ao inglês Os critérios de inclusão compreenderam artigos de revisão, pesquisas pré-clínicas e clínicas publicados, escritos em português e inglês e disponíveis em texto completo. Os artigos selecionados foram analisados com base nas tecnologias abordadas, perspectivas futuras, desafios, doenças referidas e ideia central do artigo. Resultado: Foram incluídos 36 artigos. Conclusão: O colesteatoma tem importância na prática médica, apesar de ser relativamente pouco frequente na população em geral. No entanto, ainda existem dúvidas sobre sua causa, mas seu diagnóstico tem sido ampliado atavés de exames de imagem na tentativa de redução das operações de “segundo-olhar”, evitando-as. Outro campo com crescimento constante é o tratamento cirúrgico, uma vez que a anatomia complexa exige que novas técnicas sejam manejadas para diminuir lesões de estruturas importantes e vitais da região.

https://doi.org/10.1590/SciELOPreprints.9074

Portuguese Pancreatic Club Perspectives on Pancreatic Neuroendocrine Neoplasms: Diagnosis and Staging, Associated Genetic Syndromes and Particularities of Their Clinical Approach
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Ferreira-Silva, Joel

; Meireles, Sara

; Falconi, Massimo

; Fernandes, Alexandra

; Vilas-Boas, Filipe

; Bispo, Miguel

; Rio-Tinto, Ricardo

; Rodrigues-Pinto, Eduardo

GE-Portuguese Journal of Gastroenterology

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Jun 2024, Volume 31 Nº 3 Páginas 3 - 12

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract Pancreatic neuroendocrine neoplasms (panNENs) have been historically regarded as rare, but their incidence has raised more than 6-fold over the last 3 decades, mostly owing to improvement in the detection of small asymptomatic tumours with imaging. Early detection and proper classiﬁcation and staging are essential for the prognosis and management of panNENs. Histological evaluation is mandatory in all patients for the diagnosis of panNEN. Regarding localization and staging, multiphasic contrast-enhanced computer tomography is considered the imaging study of choice. Nevertheless, several other diagnostic modalities might present complementary information that can help in diagnosis and staging optimization: magnetic resonance imaging, somatostatin receptor imaging using positron emission tomography in combination with computed tomography (PET/CT), PET/CT with ﬂuorodeoxyglucose (18F-FDG), and endoscopic ultrasound. Approximately 10%of panNENs are due to an inherited syndrome, which includes multiple endocrine neoplasia type 1, von Hippel-Lindau disease, neuroﬁbromatosis type 1 (NF-1), tuberous sclerosis complex, and Mahvash disease. In this review, the Portuguese Pancreatic Club summarizes the classiﬁcation, diagnosis, and staging of panNENs, with a focus on imaging studies. It also summarizes the characteristics and particularities of panNENs associated with inherited syndromes.

Resumo As neoplasias neuroendócrinas pancreáticas (panNENs) são historicamente consideradas raras, embora a sua incidência tenha aumentado mais de 6 vezes nas últimas três décadas, principalmente devido à otimização do diagnóstico de tumores pequenos e assintomáticos em exames de imagem. A deteção precoce, a classiﬁcação e o estadiamento adequados são essenciais para o prognóstico e abordagem dos panNENs. A avaliação histológica é obrigatória em todos os doentes para o diagnóstico de panNENs. Para a localização e estadiamento, a TC multifásica com contraste é considerada o estudo de imagem de eleição. Contudo, várias outras modalidades diagnósticas podem apresentar informações complementares que podem auxiliar no diagnóstico e na otimização do estadiamento: ressonância magnética, PET/CT dos receptores da somatostatina, PET/CT [1⁸F]FDG e ecoendoscopia. Aproximadamente 10% dos panNENs estão relacionados com síndromes hereditários, que incluem neoplasia endócrina múltipla tipo 1 (MEN1), doença de von Hippel-Lindau (VHL), neuroﬁbromatose tipo 1 (NF1), complexo de esclerose tuberosa (TSC) e doença de Mahvash. Neste artigo, o Clube Português de Pâncreas aborda a classiﬁcação, diagnóstico e estadiamento de panNENs, com foco nos estudos de imagem, bem como resume as características e particularidades dos panNENs associados aos síndromes hereditários.

https://doi.org/10.1159/000534641

[SciELO Preprints] - Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy – 2024
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Fernandes, Fabio Simões, Marcus V. Correia, Edileide de Barros Marcondes-Braga, Fabiana G. Coelho-Filho, Otavio Rizzi Mesquita, Cláudio Tinoco Mathias-Junior, Wilson Rochitte, Carlos Eduardo Ramires, Felix José Alvarez Alves, Silvia Marinho Martins Montera, Marcelo Westerlund Lopes, Renato Delascio Oliveira-Junior, Mucio Tavares Scolari, Fernando L. Avila, Walkiria Samuel Canesin, Manoel Fernandes Bacal, Fernando Bocchi, Edimar Alcides Moura, Lídia Ana Zytynski Saad, Eduardo Benchimol Scanavacca, Mauricio I. Valdigem, Bruno Pereira Cano , Manuel Nicolas Abizaid , Alexandre Ribeiro, Henrique Barbosa Lemos-Neto, Pedro Alves Ribeiro, Gustavo Calado de Aguiar Jatene, Fabio Biscegli Dias, Ricardo Ribeiro Beck-da-Silva, Luis Rohde, Luis Eduardo P. Bittencourt, Marcelo Imbroinise Pereira, Alexandre Krieger, José Eduardo Villacorta, Humberto Martins, Wolney de Andrade Figueiredo-Neto, José Albuquerque de Cardoso , Juliano Novaes Pastore, Carlos Alberto Jatene, Ieda Biscegli Tanaka, Ana Cristina Sayuri Hotta, Viviane Tiemi Romano, Minna Moreira Dias Albuquerque, Denilson Campos de Mourilhe-Rocha, Ricardo Hajjar, Ludhmila Abrahão Brito, Fabio Sandoli de Caramelli , Bruno Calderaro, Daniela Farsky, Pedro Silvio Colafranceschi , Alexandre Siciliano Pinto, Ibraim Masciarelli Vieira , Marcelo Luiz Campos Danzmann, Luiz Claudio Barberato , Silvio Henrique Mady, Charles Martinelli-Filho, Martino Torbey , Ana Flavia Malheiros Schwartzmann, Pedro Vellosa Macedo, Ariane Vieira Scarlatelli Ferreira , Silvia Moreira Ayub Schmidt, Andre Melo , Marcelo Dantas Tavares de Lima-Filho, Moysés Oliveira Sposito, Andrei C. Brito, Flavio de Souza Biolo, Andreia Madrini-Junior, Vagner Rizk, Stéphanie Itala Mesquita, Evandro Tinoco

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Data de publicação: 2024-04-08

Resumo: Pt Es En

A cardiomiopatia hipertrófica (CMH) é uma forma de doença do músculo cardíaco de causa genética, caracterizada pela hipertrofia das paredes ventriculares. O diagnóstico requer detecção por métodos de imagem (Ecocardiograma ou Ressonância Magnética Cardíaca) de qualquer segmento da parede do ventrículo esquerdo com espessura > 15 mm, sem outra causa provável. A análise genética permite identificar mutações de genes codificantes de diferentes estruturas do sarcômero responsáveis pelo desenvolvimento da CMH em cerca de 60% dos casos, permitindo o rastreio de familiares e aconselhamento genético, como parte importante do manejo dos pacientes e familiares. Vários conceitos sobre a CMH foram recentemente revistos, incluindo sua prevalência de 1 em 250 indivíduos, não sendo, portanto, uma doença rara, mas subdiagnosticada. A vasta maioria dos pacientes é assintomática. Naqueles sintomáticos, a obstrução do trato de saída do ventrículo esquerdo (OTSVE) é o principal distúrbio responsável pelos sintomas, devendo-se investigar a sua presença em todos os casos. Naqueles em que o ecocardiograma em repouso ou com Manobra de Valsalva não detecta gradiente intraventricular significativo (> 30 mmHg), devem ser submetidos à ecocardiografia com esforço físico para detecção da OTSVE.   Pacientes com sintomas limitantes e grave OTSVE, refratários ao uso de betabloqueadores e verapamil, devem receber terapias de redução septal ou uso de novas drogas inibidoras da miosina cardíaca. Por fim, os pacientes adequadamente identificados com risco aumentado de morta súbita podem receber medida profilática com implante de cardiodesfibrilador implantável (CDI).

La miocardiopatía hipertrófica (MCH) es una forma de enfermedad cardíaca de origen genético, caracterizada por el engrosamiento de las paredes ventriculares. El diagnóstico requiere la detección mediante métodos de imagen (Ecocardiograma o Resonancia Magnética Cardíaca) que muestren algún segmento de la pared ventricular izquierda con un grosor > 15 mm, sin otra causa probable. El análisis genético permite identificar mutaciones en genes que codifican diferentes estructuras del sarcómero responsables del desarrollo de la MCH en aproximadamente el 60% de los casos, lo que permite el tamizaje de familiares y el asesoramiento genético, como parte importante del manejo de pacientes y familiares. Varios conceptos sobre la MCH han sido revisados recientemente, incluida su prevalencia de 1 entre 250 individuos, por lo tanto, no es una enfermedad rara, sino subdiagnosticada. La gran mayoría de los pacientes son asintomáticos. En los casos sintomáticos, la obstrucción del tracto de salida ventricular izquierdo (TSVI) es el trastorno principal responsable de los síntomas, y su presencia debe investigarse en todos los casos. En aquellos en los que el ecocardiograma en reposo o la maniobra de Valsalva no detecta un gradiente intraventricular significativo (> 30 mmHg), deben someterse a ecocardiografía de esfuerzo para detectar la obstrucción del TSVI. Los pacientes con síntomas limitantes y obstrucción grave del TSVI, refractarios al uso de betabloqueantes y verapamilo, deben recibir terapias de reducción septal o usar nuevos medicamentos inhibidores de la miosina cardíaca. Finalmente, los pacientes adecuadamente identificados con un riesgo aumentado de muerte súbita pueden recibir medidas profilácticas con el implante de un cardioversor-desfibrilador implantable (CDI).

Hypertrophic cardiomyopathy (HCM) is a form of genetically caused heart muscle disease, characterized by the thickening of the ventricular walls. Diagnosis requires detection through imaging methods (Echocardiogram or Cardiac Magnetic Resonance) showing any segment of the left ventricular wall with a thickness > 15 mm, without any other probable cause. Genetic analysis allows the identification of mutations in genes encoding different structures of the sarcomere responsible for the development of HCM in about 60% of cases, enabling screening of family members and genetic counseling, as an important part of patient and family management. Several concepts about HCM have recently been reviewed, including its prevalence of 1 in 250 individuals, hence not a rare but rather underdiagnosed disease. The vast majority of patients are asymptomatic. In symptomatic cases, obstruction of the left ventricular outflow tract (LVOT) is the primary disorder responsible for symptoms, and its presence should be investigated in all cases. In those where resting echocardiogram or Valsalva maneuver does not detect significant intraventricular gradient (> 30 mmHg), they should undergo stress echocardiography to detect LVOT obstruction. Patients with limiting symptoms and severe LVOT obstruction, refractory to beta-blockers and verapamil, should receive septal reduction therapies or use new drugs inhibiting cardiac myosin. Finally, appropriately identified patients at increased risk of sudden death may receive prophylactic measure with implantable cardioverter-defibrillator (ICD) implantation.

https://doi.org/10.1590/SciELOPreprints.8394

Nitrogen efficiency in marandupalisadegrass pastures under increasing nitrogen levels
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Quadros, Fernando Luiz Ferreira de

; Ongaratto, Fernando

; Malheiros, Euclides Braga

; Lima, Laís de Oliveira

; Dallantonia, Erick Escobar

; Romanzini, Eliéder Prates

; Velludo, Igor de Martin

; Cardoso, Abmael da Silva

; Val, Guilherme Alves do

; Rigobello, Izabela Larosa

; Fernandes, Márcia Helena Machado da Rocha

; Reis, Ricardo Andrade

Ciência Rural

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2024, Volume 54 Nº 3 elocation e20230049

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT: The use of nitrogen (N) in pastoral ecosystems leads to increased productivity, as it allows the plant to elongate its leaves and, therefore, grazing herbivores harvest the green leaves. However, there are very volatile N sources, which can be replaced by ammonium nitrate, which is less volatile and less dependent on the application in rainy days. The treatments are compound of Marandu palisade grass pastures managed under continuous stocking at a canopy height of 25 cm, with different levels of N fertilizer: 0, 75, and 150 kg ha-1year-1, as ammonium nitrate (32% of N), with four replicates (pastures) in a completely randomized design. Nitrogen uptake (54.9, 96.5, 113.8 kg N ha-1) and N nutrition index (0.67, 0.98, 1.15) were different between N level, respectively, 0, 75 and 150 kg ha-1 year-1. The N recovery (58.3, 40.9 %) differed between 75 and 150 kg ha-1 year-1, respectively. The dose of 75 kg N kg ha-1 year-1 results in better N utilization, while the dose of 150 kg N ha-1 year-1 enables greater stocking rate; therefore, requiring less grazing area. ABSTRACT (N productivity therefore However sources days 2 cm fertilizer 0 15 ha1year1, ha1year1 hayear ha 1year 1, 1 year ha-1year-1 32% 32 (32 N, , N) (pastures design 54.9, 549 54 9 (54.9 965 96 5 96.5 1138 113 8 113. ha1 0.67, 067 67 (0.67 098 98 0.98 1.15 115 level respectively 7 ha- year1. year1 1. 58.3, 583 58 3 (58.3 409 40 40. % year1, year- utilization rate area ha1year ha-1year- (3 54.9 (54. 96. 11 0.67 06 6 (0.6 09 0.9 1.1 58.3 (58. 4 ha-1year ( 54. (54 0.6 (0. 0. 58. (58 (5 (0

RESUMO: O uso de nitrogênio (N) em ecossistemas pastoris leva ao aumento da produtividade, pois permite que a planta alongue suas folhas e, portanto, os herbívoros colham as folhas verdes. Porém, existem fontes de nitrogênio muito voláteis, que devem ser substituídas por nitrato de amônio, que é menos volátil e menos dependente da aplicação em dias chuvosos. Os tratamentos foram compostos por pastagens de capim-marandu, manejadas sob lotação contínua, na altura do dossel a 25 cm, com diferentes doses de N: 0, 75 e 150 kg ha-1 ano-1, na forma de nitrato de amônio (32% de N), com quatro repetições (piquetes), em delineamento inteiramente casualizado. A absorção de nitrogênio (54,9; 96,5; 113,8 kg N ha-1) e o índice nutricional de N (0,67; 0,98; 1,15) foram diferentes entre as doses de N, respectivamente, 0, 75 e 150 kg ha-1 ano-1. A recuperação de N (58,3; 40,9%) diferiu entre 75 e 150 kg ha-1 ano-1, respectivamente. A dose de 75 kg N kg ha-1 ano-1 resultou em melhor aproveitamento do N, enquanto a dose de 150 kg N ha-1 ano-1 possibilita maior taxa de lotação; portanto, exigindo menos área de pastagem. RESUMO (N produtividade portanto verdes Porém voláteis chuvosos capimmarandu, capimmarandu capim marandu, marandu capim-marandu contínua 2 cm 0 7 15 ha1 ha 1 ha- ano1, ano1 ano 1, 32% 32 (32 , N) piquetes, piquetes (piquetes) casualizado 54,9 549 54 9 (54,9 96,5 965 96 5 1138 113 8 113, 0,67 067 67 (0,67 0,98 098 98 1,15 115 respectivamente ano1. 1. 58,3 583 58 3 (58,3 40,9% 409 40 ano- pastagem (3 (piquetes 54, (54, 96, 11 0,6 06 6 (0,6 0,9 09 1,1 58, (58, 40,9 4 ( (54 (0, (58 40, (5 (0

https://doi.org/10.1590/0103-8478cr20230049

CAPACIDADES ESTATAIS E IMPLEMENTAÇÃO DE POLÍTICAS EDUCACIONAIS NO NÍVEL LOCAL: A TRAJETÓRIA DA BASE NACIONAL COMUM CURRICULAR EM UM MUNICÍPIO MINEIRO LOCAL
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Oliveira, Breynner Ricardo de

; Alves, Maria Michelle Fernandes

Cadernos Gestão Pública e Cidadania

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2024, Volume 29 elocation e89154

Resumo: Es En Pt | Texto: Es En Pt | PDF: Es | PDF: En | PDF: Pt

RESUMEN Este artículo analiza las conexiones entre las Capacidades Estatales de la Secretaría Municipal de Educación (SME) de Contagem (Minas Gerais) y la trayectoria de implementación de la Base Curricular Común Nacional (BNCC) en la Enseñanza Fundamental. La investigación documental y cualitativa analizó dos dimensiones en el ciclo de gobierno 2017-2020: técnico-administrativa y político-relacional. Respecto a la primera, la Secretaría Municipal de Educación (SME) coordinó, a través de la Dirección de Formación (DF), un programa de capacitación que formuló e implementó un nuevo currículo alineado con las directrices de la BNCC. Destacamos la trayectoria y experiencia institucional de la SME y el perfil de los ejecutores en el organismo. La segunda dimensión destaca las dificultades de la SME para establecer alianzas con otros actores y la falta de cooperación institucional con el Estado. El hecho de que Contagem gestiona tu propio sistema educativo contribuyó a que la SME constituyera su ethos y capacidades institucionales, lo que contribuyó a la implementación de la base. (SME Minas Gerais BNCC (BNCC Fundamental 20172020 2017 2020 2017-2020 técnicoadministrativa técnico administrativa políticorelacional. políticorelacional político relacional. relacional político-relacional primera coordinó DF, DF , (DF) organismo Estado institucionales base 2017202 201 202 2017-202 (DF 201720 20 2017-20 20172 2 2017-2 2017-

ABSTRACT This article analyzes the connections between the State Capacities of the Municipal Department of Education (SME) of Contagem (Minas Gerais) and the trajectory of implementation of the National Common Curricular Base (BNCC) in Elementary School. The documentary and qualitative research analyzed two dimensions in the 2017-2020 government cycle: technical-administrative and political-relational. Regarding the first, the SME coordinated, through the Training Board (DF), a training program that formulated and implemented a new curriculum aligned with the BNCC guidelines. We highlight the trajectory and institutional expertise of the SME and the profile of the implementers in the body. The second dimension highlights the SME’s difficulties in establishing partnerships with other actors and the lack of institutional cooperation with the state. The fact that Contagem manage your own education system contributed to the SME constituting its ethos and institutional capabilities, which contributed to the implementation of the base. (SME Minas Gerais (BNCC School 20172020 2017 2020 2017-202 cycle technicaladministrative technical administrative politicalrelational. politicalrelational political relational. relational political-relational first coordinated DF, DF , (DF) guidelines body SMEs s state capabilities base 2017202 201 202 2017-20 (DF 201720 20 2017-2 20172 2 2017-

RESUMO Este artigo analisa as conexões entre as Capacidades Estatais (CE) da Secretaria Municipal de Educação (SME) de Contagem (Minas Gerais) e a trajetória de implementação da Base Nacional Comum Curricular (BNCC), no Ensino Fundamental (EF). A pesquisa, documental e qualitativa, analisou duas dimensões, no ciclo de governo 2017-2020: técnico-administrativa e político-relacional. Sobre a primeira, a SME coordenou, por meio da Diretoria de Formação (DF), um programa de formação que formulou e implementou um novo currículo alinhado às diretrizes da BNCC. Destacamos a trajetória e a expertise institucional da SME e o perfil dos implementadores no órgão. A segunda dimensão evidencia as dificuldades da SME em estabelecer parcerias com outros atores e a ausência de cooperação institucional com o estado. O fato de Contagem gerir um sistema de ensino próprio contribuiu para que a SME constituísse seu ethos e suas capacidades institucionais, o que contribuiu para a implementação da base. CE (CE (SME Minas Gerais BNCC, BNCC , (BNCC) EF. EF . (EF) pesquisa qualitativa dimensões 20172020 2017 2020 2017-2020 técnicoadministrativa técnico administrativa políticorelacional. políticorelacional político relacional. relacional político-relacional primeira coordenou DF, DF (DF) órgão estado institucionais base (BNCC (EF 2017202 201 202 2017-202 (DF 201720 20 2017-20 20172 2 2017-2 2017-

https://doi.org/10.12660/cgpc.v29.89154

Prolonged survival after thoracic metastasectomy in patients with nonseminomatous testicular cancer
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Fonini, Jaqueline Schaparini

; de Araujo, Pedro Henrique Xavier Nabuco

; D'Ambrosio, Paula Duarte

; Salerno, Juliana Vieira de Oliveira

; Ciaralo, Pedro Prosperi Desenzi

; Terra, Ricardo Mingarini

; Pêgo-Fernandes, Paulo Manuel

Clinics

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2024, Volume 79 elocation 100338

Resumo: En | Texto: En | PDF: En

Abstract Introduction Almost 20 % of patients with Non-Seminomatous Germinative Cell Tumors (NSGCT) will require intrathoracic metastasectomy after chemotherapy. The authors aim to determine their long-term survival rates. Methods Retrospective study including patients with NSGCT and intrathoracic metastasis after systemic therapy from January 2011 to June 2022. Treatment outcomes and overall survival were analyzed with the Kaplan-Meier method. Results Thirty-seven male patients were included with a median age of 31.8 years. Six presented with synchronous mediastinum and lung metastasis, nine had only lung, and 22 had mediastinal metastasis. Over half had retroperitoneal lymph node metastasis. Twenty-two had dissimilar pathologies, with a discordance rate of 62 %. Teratoma and embryonal carcinoma were the prevalent primary tumor types, 40.5 % each, while teratoma was predominant (70.3 %) in the metastasis group. Thoracotomy was the main surgical approach (39.2 %) followed by VATS (37.2 %), cervico-sternotomy (9.8 %), sternotomy (5.8 %), and clamshell (3.9 %). Lung resection was performed in 40.5 % of cases. Overall, 10-year survival rates were 94.3 % with no surgical-related mortality. Conclusion Multimodality treatment with systemic therapy followed by radical surgery offers a high cure rate to patients with intrathoracic metastatic testicular germ cell tumors. 2 NonSeminomatous Non Seminomatous (NSGCT chemotherapy longterm long term 201 2022 KaplanMeier Kaplan Meier method Thirtyseven Thirty seven 318 31 8 31. years Twentytwo Twenty two pathologies 6 types 405 40 5 40. each 70.3 703 70 3 (70. group 39.2 392 39 (39. 37.2 372 37 (37. %, , cervicosternotomy cervico 9.8 98 9 (9. 5.8 58 (5. 3.9 (3. . cases Overall 10year year 10 943 94 94. surgicalrelated related mortality tumors 202 4 70. 7 (70 39. (39 37. (37 9. (9 5. (5 3. (3 1 (7 (

https://doi.org/10.1016/j.clinsp.2024.100338

Pioneer of Cardiothoracic Surgery - Luiz Tavares da Silva
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Lima, Ricardo de Carvalho

; Lima, Leonardo Pontual

; Escobar, Mozart Augusto Soares de

; Cabral, José Ricardo Lagreca de Sales

; Vieira, José Aécio Fernandes

; Maia, Guilherme Tavares da Silva

Brazilian Journal of Cardiovascular Surgery

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2024, Volume 39 Nº 1 elocation e20230046

Resumo: En | Texto: En | PDF: En

ABSTRACT Luis Tavares revolutionized cardiac surgery, always bringing the most modern instruments and equipment from his travels to England - surgical forceps, scissors, scalpels, etc. He always insisted that he was not just a thoracic surgeon, for his work extended over a wide field and created three important cardiac surgery centers which promoted a great development of cardiology. He carried out the first open heart surgery (atrial septal defect) employing extracorporeal circulation and closure of a ventricular septal defect with deep surface hypothermia of north and northeast Brazil. He promoted an intense scientific exchange program between Recife and England, resulting in significant advances in medicine, and participated directly in the creation of HEMOPE), leading to radical changes and improvements in blood therapy in the whole country. The PROCAPE, inaugurated in 2006, was the result of the cardiac center created by him in early 1970 at Hospital Oswaldo Cruz and can be considered the second largest public-university cardiology center in Brazil. He is thus widely regarded as an outstanding name in medicine in the 20th century and one of the fathers of modern cardiac surgery in Brazil. forceps scissors scalpels etc surgeon atrial Brazil HEMOPE, HEMOPE , HEMOPE) country PROCAPE 2006 197 publicuniversity public university th 200 19 20 1 2

https://doi.org/10.21470/1678-9741-2023-0046

Fungos trametoides (Polyporaceae, Basidiomycota) do Parque Estadual das Fontes do Ipiranga, São Paulo, Estado de São Paulo, Brasil Polyporaceae, Polyporaceae (Polyporaceae Basidiomycota Ipiranga Paulo
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Fernandes, Mariana

; Gugliotta, Adriana de Mello

; Silva, Daniele Santana da

; Pires, Ricardo Matheus

Hoehnea

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2024, Volume 51 elocation e202023

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT A survey of trametoid fungi species from Parque Estadual das Fontes do Ipiranga (PEFI), located in the city of São Paulo, SP, Brazil (23o38’00”S-23o40’18”S, 46o36’48”W-46o38’08”W), was carried out. Fifteen species belonging to six genera were identified from the analysis of macro and micro morphology in which the dimensions of the basidiomata, texture, color, as well as, the size of hyphae, basidia, basidiospores and cystidia, were evaluated. The species are distributed in: Cerrena Gray (uma sp.), Funalia Pat. (1 sp.), Hexagonia Fr. (duas spp.), Lenzites Fr. (uma sp.), Podofomes Pouzar (duas spp.), Pycnoporus T. Karst. (uma sp.), and Trametes Fr. (sete spp). Trametes lactinea (Berk.) Sacc. was found as a new record for the State of São Paulo; Podofomes mollis (Sommerf.) Gorjón, P. stereoides (Fr.) Gorjón, Trametes cubensis (Mont.) Sacc., T. decipiens Bres. and T. neovillosa Fernandes & Gugliotta are reported for the first time from the locality. Identification key, descriptions and comments of the taxa studied are provided herewith. PEFI, PEFI , (PEFI) Paulo SP 23o3800S23o4018S, 23o3800S23o4018S oSoS 23o38 00 S 23o40 18 S, o (23o38’00”S-23o40’18”S 46o3648W46o3808W, 46o3648W46o3808W oWoW 46o36 48 W 46o38 08 46o36’48”W-46o38’08”W) out basidiomata texture color hyphae basidia cystidia evaluated uma sp., sp sp. sp.) Pat 1 ( Fr duas spp., spp spp. spp.) T Karst sete . spp) Berk. Berk (Berk. Sacc Sommerf. Sommerf (Sommerf. Gorjón P (Fr. Mont. Mont (Mont. Bres locality key herewith (PEFI 23o3 0 23o4 46o3 4 46o36’48”W-46o38’08”W (Berk (Sommerf (Fr (Mont 23o 46o

RESUMO Foi realizado o levantamento das espécies de fungos trametoides do Parque Estadual das Fontes do Ipiranga (PEFI), localizado no município de São Paulo, São Paulo, Brasil (23o38’00”S-23o40’18”S, 46o36’48”W-46o38’08”W). Quinze espécies pertencentes a seis gêneros foram identificadas a partir da análise da macro e micromorfologia, em que foram avaliadas as dimensões dos basidiomas, textura, cor, assim como o tamanho das hifas, basídios, basidiósporos e cistídios. As espécies estão distribuídas em: Cerrena Gray (one sp.), Funalia Pat. (one sp.), Hexagonia Fr. (two spp.), Lenzites Fr. (one sp.), Podofomes Pouzar (two spp.), Pycnoporus T. Karst. (one sp.), and Trametes Fr. (seven spp). Trametes lactinea (Berk.) Sacc. foi encontrado como novo registro para o Estado de São Paulo; Podofomes mollis (Sommerf.) Gorjón, P. stereoides (Fr.) Gorjón, Trametes cubensis (Mont.) Sacc., T. decipiens Bres. e T. neovillosa Fernandes & Gugliotta são relatados pela primeira vez para a localidade. Chave de identificação, descrições e comentários dos táxons estudados são fornecidos a seguir. PEFI, PEFI , (PEFI) Paulo 23o3800S23o4018S, 23o3800S23o4018S oSoS 23o38 00 S 23o40 18 S, (23o38’00”S-23o40’18”S 46o3648W46o3808W. 46o3648W46o3808W oWoW 46o36 48 W 46o38 08 . 46o36’48”W-46o38’08”W) micromorfologia basidiomas textura cor hifas basídios cistídios one sp., sp sp. sp.) Pat Fr two spp., spp spp. spp.) T Karst seven spp) Berk. Berk (Berk. Sacc Sommerf. Sommerf (Sommerf. Gorjón P (Fr. Mont. Mont (Mont. Bres localidade identificação seguir (PEFI 23o3 0 23o4 1 46o3 4 46o36’48”W-46o38’08”W (Berk (Sommerf (Fr (Mont 23o 46o

https://doi.org/10.1590/2236-8906e202023

10.

The association of visceral pleural invasion with skip N2 metastasis on clinical stage IA NSCLC N
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Minamoto, Fabio

; Araújo, Pedro

; D'Ambrosio, Paula

; Vega, Alberto Dela

; Lauricella, Leticia

; Pêgo-Fernandes, Paulo

; Terra, Ricardo

Clinics

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2024, Volume 79 elocation 100334

Resumo: En | Texto: En | PDF: En

Abstract Background Lung lymphatic drainage occurs mainly through a peribronchial path, but it is hypothesized that visceral pleural invasion could alter this path. This study aims to investigate the association between visceral pleural invasion, node upstaging, and N2 skip metastasis and the impact on survival in a population of patients with non-small cell lung cancer of 3 cm or smaller. Methods We retrospectively queried our institutional database of lung cancer resection for all patients with clinical stage IA NSCLC between June 2009 and June 2022. We collected baseline characteristics and clinical and pathological staging data. Patients were classified into two groups: The non-VPI group with negative visceral pleural invasion and the VPI group with positive. The primary results analyzed were the occurrence of nodal upstaging, skip N2 metastasis and recurrence. Results There were 320 patients analyzed. 61.3 % were women; the median age was 65.4 years. The pleural invasion occurred in 44 patients (13.7 %). VPI group had larger nodules (2.3 vs. 1.7 cm; p < 0.0001), higher 18F-FDG uptake (7.4 vs. 3.4; p < 0.0001), and lymph-vascular invasion (35.7 % vs. 13.5 %, p = 0.001). Also, the VPI group had more nodal disease (25.6 % vs. 8.7 %; p = 0.001) and skip N2 metastasis (9.3 % vs. 1.8 %; p = 0.006). VPI was a statistically independent factor for skip N2 metastasis. Recurrence occurred in 17.2 % of the population. 5-year disease-free and overall survival were worse in the VPI group. Conclusions The visceral pleural invasion was an independent factor associated with N2 skip metastasis and had worse disease-free and overall survival. path upstaging N nonsmall non small smaller 200 2022 data groups nonVPI positive recurrence 32 613 61 61. women 654 65 4 65. years 13.7 137 13 7 (13. %. . %) 2.3 23 2 (2. vs 17 1 1. 0.0001, 00001 0.0001 , 0 0001 0.0001) 18FFDG FFDG 18F FDG F 7.4 74 (7. 3.4 34 lymphvascular lymph vascular 35.7 357 35 (35. 135 5 13. 0.001. 0.001 001 Also 25.6 256 25 6 (25. 87 8 8. 9.3 93 9 (9. 18 0.006. 0006 0.006 006 0.006) 172 17. 5year year diseasefree free 20 202 (13 2. (2 0000 0.000 000 7. (7 3. 35. (35 0.00 00 25. (25 9. (9 (1 ( (3 0.0 0.

https://doi.org/10.1016/j.clinsp.2024.100334

11.

Do baseline participant characteristics impact the effectiveness of a mobile health intervention for depressive symptoms? A post-hoc subgroup analysis of the CONEMO trials symptoms posthoc post hoc
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Claro, Heloísa Garcia

; Menezes, Paulo Rossi

; Fernandes, Ivan Filipe

; Seward, Nadine

; Miranda, Juan Jaime

; Saidel, Maria Giovana Borges

; Baquete, Aline Geovanna de Lima

; Daley, Kate L.

; Aschar, Suzana

; Cruz, Daniela Vera

; Castro, Hellen Carolina Martins

; Rocha, Thais

; Quayle, Julieta

; Peters, Tim J.

; Araya, Ricardo

Brazilian Journal of Psychiatry

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2024, Volume 46 elocation e20233172

Resumo: En | Texto: En | PDF: En

Objective: To ascertain whether sociodemographic and health-related characteristics known from previous research to have a substantive impact on recovery from depression modified the effect of a digital intervention designed to improve depressive symptoms (CONEMO). Methods: The CONEMO study consisted of two randomized controlled trials, one conducted in Lima, Peru, and one in São Paulo, Brazil. As a secondary trial plan analysis, mixed logistic regression was used to explore interactions between the treatment arm and subgroups of interest defined by characteristics measured before randomization – suicidal ideation, race/color, age, gender, income, type of mobile phone, alcohol misuse, tobacco use, and diabetes/hypertension – in both trials. We estimated interaction effects between the treatment group and these subgroup factors for the secondary outcomes using linear mixed regression models. Results: Increased effects of the CONEMO intervention on the primary outcome (reduction of at least 50% in depressive symptom scores at 3-month follow-up) were observed among older and wealthier participants in the Lima trial (p = 0.030 and p = 0.001, respectively). Conclusion: There was no evidence of such differential effects in São Paulo, and no evidence of impact of any other secondary outcomes in either trial. Clinical trial registration: NCT02846662 (São Paulo, Brazil – SP), NCT03026426 (Lima, Peru – LI). Funded by the U.S. National Institute of Mental Health (grant U19MH098780). Objective healthrelated health related CONEMO. . (CONEMO) Methods trials Paulo analysis ideation racecolor race color race/color age gender income phone misuse use diabeteshypertension diabetes hypertension models Results reduction 50 3month month 3 followup follow up follow-up 0030 0 030 0.03 0001 001 0.001 respectively. respectively respectively) Conclusion registration NCT NCT0284666 SP, SP , SP) NCT0302642 (Lima LI. LI LI) US U S U.S grant U19MH098780. U19MH098780 UMH MH U19MH098780) (CONEMO 5 003 03 0.0 000 00 0.00 NCT028466 NCT030264 U19MH09878 0. NCT02846 NCT03026 U19MH0987 NCT0284 NCT0302 U19MH098 NCT028 NCT030 U19MH09 NCT02 NCT03 U19MH0 NCT0 U19MH

https://doi.org/10.47626/1516-4446-2023-3172

12.

Does Antimicrobial Photodynamic Therapy Influence the Bond Strength of Direct Restorative Materials to Healthy and Decayed Dentin? A Systematic Review Dentin
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Mendes, Raíssa Martins

; Fernandes, Thais de Oliveira

; Hidalgo, Ricardo

; Antunes, Leonardo dos Santos

; Cajazeira, Marlus Roberto Rodrigues

; Antunes, Lívia Azeredo Alves

Pesquisa Brasileira em Odontopediatria e Clínica Integrada

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2024, Volume 24 elocation e230082

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: To evaluate the influence of antimicrobial photodynamic therapy (aPDT) on the bond strength of adhesive restorative materials to healthy and caries-affected dentin. Material and Methods: 04 electronic databases and 02 additional searches were assessed. In vitro studies considering sound or caries-affected human or bovine dentin (population), use of aPDT before restorative treatment (intervention), use of other dentin disinfection techniques (comparison), and bond strength to dentin (outcome) were included. The risk of bias for in vitro studies was used as a method to check the evidence. The method used to present and synthesize results was data extraction. Results: The total number of included studies was 11, including 550 permanent teeth. Bond strength was evaluated mainly through the shear bond strength (SBS) test, with dentin affected by caries being the substrate most frequently used in studies. Six studies demonstrated that aPDT with methylene blue (MB) negatively affected the SBS values of resin-modified glass ionomer cement (RMGIC) to dentin. Regarding risk of bias assessment, all studies were at high risk of bias. Conclusion: The effects of aPDT on adhesion to dentin vary depending on the type of substrate and the photosensitizer used. Mainly, MB negatively affected the SBS values from RMGIC to dentin. The conclusion should be interpreted considering the high risk of bias in the studies. Objective (aPDT cariesaffected Methods 0 assessed population, population , (population) intervention, intervention (intervention) comparison, comparison (comparison) outcome (outcome evidence extraction Results 11 55 teeth (SBS test (MB resinmodified resin modified (RMGIC assessment Conclusion Mainly (population (intervention (comparison 1 5

https://doi.org/10.1590/pboci.2024.077

13.

To be or not to B27 positive: implications for the phenotypes of axial spondyloarthritis outcomes. Data from a large multiracial cohort from the Brazilian Registry of Spondyloarthritis B B2 positive outcomes
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Resende, Gustavo Gomes

; Saad, Carla Goncalves Schahin

; Marques, Claudia Diniz Lopes

; Ribeiro, Sandra Lúcia Euzébio

; Gavi, Maria Bernadete Renoldi de Oliveira

; Yazbek, Michel Alexandre

; Marinho, Adriana de Oliveira

; Menin, Rita de Cássia

; Ochtrop, Manuella Lima Gomes

; Soares, Andressa Miozzo

; Cavalcanti, Nara Gualberto

; Carneiro, Jamille Nascimento

; Werner de Castro, Glaucio Ricardo

; Fernandes, José Mauro Carneiro

; Souza, Elziane da Cruz Ribeiro E

; Alvarenga, Corina Quental de Menezes

; Vieira, Rejane Maria Rodrigues de Abreu

; Machado, Natalia Pereira

; Ximenes, Antônio Carlos

; Gazzeta, Morgana Ohira

; Albuquerque, Cleandro Pires de

; Skare, Thelma Larocca

; Keiserman, Mauro Waldemar

; Kohem, Charles Lubianca

; Benacon, Gabriel Sarkis

; Rocha, Vítor Florêncio Santos

; Lage, Ricardo da Cruz

; Malheiro, Olivio Brito

; Golebiovski, Rywka Tenenbaum Medeiros

; Oliveira, Thauana Luiza

; Duque, Ruben Horst

; Londe, Ana Carolina

; Pinheiro, Marcelo de Medeiros

; Sampaio-Barros, Percival Degrava

Advances in Rheumatology

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2024, Volume 64 elocation 33

Resumo: En | Texto: En | PDF: En

Abstract Background There is a remarkable variability in the frequency of HLA-B27 positivity in patients with spondyloarthritis (SpA), which may be associated with different clinical presentations worldwide. However, there is a lack of data considering ethnicity and sex on the evaluation of the main clinical and prognostic outcomes in mixed-race populations. The aim of this study was to evaluate the frequency of HLA-B27 and its correlation with disease parameters in a large population of patients from the Brazilian Registry of Spondyloarthritis (RBE). Methods The RBE is a multicenter, observational, prospective cohort that enrolled patients with SpA from 46 centers representing all five geographic regions of Brazil. The inclusion criteria were as follow: (1) diagnosis of axSpA by an expert rheumatologist; (2) age ≥18 years; (3) classification according to ASAS axial. The following data were collected via a standardized protocol: demographic data, disease parameters and treatment historical. Results A total of 1096 patients were included, with 73.4% HLA-B27 positivity and a mean age of 44.4 (±13.2) years. Positive HLA-B27 was significantly associated with male sex, earlier age at disease onset and diagnosis, uveitis, and family history of SpA. Conversely, negative HLA-B27 was associated with psoriasis, higher peripheral involvement and disease activity, worse quality of life and mobility. Conclusions Our data showed that HLA-B27 positivity was associated with a classic axSpA pattern quite similar to that of Caucasian axSpA patients around the world. Furthermore, its absence was associated with peripheral manifestations and worse outcomes, suggesting a relevant phenotypic difference in a highly miscegenated population. HLAB27 HLAB HLA B27 B HLA-B2 SpA, , (SpA) worldwide However mixedrace mixed race populations RBE. . (RBE) multicenter observational 4 Brazil follow 1 (1 rheumatologist 2 (2 18 ≥1 years 3 (3 axial protocol historical 109 included 734 73 73.4 444 44 44. ±13.2 132 13 (±13.2 uveitis Conversely psoriasis activity mobility world Furthermore HLAB2 B2 HLA-B (SpA (RBE ( ≥ 10 7 73. ±13. (±13. ±13 (±13 ±1 (±1 ± (±

https://doi.org/10.1186/s42358-024-00372-0

14.

Noteworthy records of the ticks Ornithodoros rostratus and Amblyomma sculptum parasitizing Pteronura brasiliensis in the central-western region of Brazil, with pathogen investigation notes centralwestern central western Brazil
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Barros-Battesti, Darci Moraes

; André, Marcos Rogério

; Hoppe, Estevam Guilherme Lux

; Sanches, Gustavo Seron

; Bassini-Silva, Ricardo

; Calchi, Ana Claúdia

; Andrade, Lívia Oliveira

; Perin, Patrícia Parreira

; Martins, Thiago Fernandes

; Castro-Santiago, Ana Carolina

; Leuchtenberger, Caroline

; Almeida, Samara

; Foerster, Nathalie

; Furtado, Mariana

; de Castro Jacinavicius, Fernando

Revista Brasileira de Parasitologia Veterinária

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2024, Volume 33 Nº 1 elocation e014523

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

Abstract A male of Pteronura brasiliensis (Carnivora: Mustelidae) was found dead on the banks of the Rio Negro, in the Pantanal wetlands of Mato Grosso do Sul state, Aquidauana municipality. Two ticks found attached to its skin were morphologically identified as a second-instar nymph of Ornithodoros rostratus (Argasidae) and a male of Amblyomma sculptum (Ixodidae). In order to complement the morphological identification, these tick specimens were subjected to DNA extraction, and tested using PCR assays to confirm the molecular identity the specimens. Also, the tick DNA samples were tested and were negative in the PCR assays for all the pathogens tested. We also examined 30 batches, consisting of 174 individuals of O. rostratus deposited in the Acari Collection of the Butantan Institute, and we found material from four Brazilian states, including one batch containing 2 males and 2 females from Aquidauana, of Mato Grosso do Sul state, collected from the soil. This was therefore the first record of O. rostratus parasitizing P. brasiliensis and the first locality record (Aquidauana). Likewise, A. sculptum is commonly found in the Pantanal and is reported here for the second time parasitizing the giant otter, which is a host little studied regarding the ectoparasites. Carnivora (Carnivora Mustelidae Negro state municipality secondinstar instar Argasidae (Argasidae Ixodidae. Ixodidae . (Ixodidae) identification extraction Also 3 batches 17 O Institute states soil P Aquidauana. (Aquidauana) Likewise otter ectoparasites (Ixodidae 1 (Aquidauana

Resumo Um macho de Pteronura brasiliensis (Carnivora: Mustelidae) foi encontrado morto às margens do Rio Negro, no Pantanal do estado de Mato Grosso do Sul, município de Aquidauana. Dois carrapatos encontrados aderidos à sua pele foram identificados, morfologicamente, como uma ninfa de segundo ínstar de Ornithodoros rostratus (Argasidae) e um macho de Amblyomma sculptum (Ixodidae). Para complementar a identificação morfológica, esses espécimes de carrapatos foram submetidos à extração de DNA e testados por meio de ensaios de PCR, para confirmar a identidade molecular dos espécimes. Além disso, os extraídos dos carrapatos foram testados e revelaram-se negativos nos ensaios de PCR para todos os patógenos testados. Também foram examinados 30 lotes, compostos por 174 indivíduos de O. rostratus, depositados na Coleção Acari do Instituto Butantan, e encontramos material de quatro estados brasileiros, incluindo-se um lote contendo 2 machos e 2 fêmeas de Aquidauana, estado de Mato Grosso do Sul (MS), coletado do solo. Este foi, portanto, o primeiro registro de O. rostratus parasitando P. brasiliensis e o primeiro registro de localidade (Aquidauana). Da mesma forma, A. sculptum é comumente encontrado no Pantanal e relatado aqui, pela segunda vez, parasitando a ariranha, hospedeiro pouco estudado em relação a ectoparasitas. Carnivora (Carnivora Mustelidae Negro Aquidauana identificados morfologicamente Argasidae (Argasidae Ixodidae. Ixodidae . (Ixodidae) morfológica disso revelaramse revelaram se 3 lotes 17 O Butantan brasileiros incluindose incluindo MS, MS , (MS) solo portanto P (Aquidauana) forma A aqui vez ariranha ectoparasitas (Ixodidae 1 (MS (Aquidauana

https://doi.org/10.1590/s1984-29612024003

15.

Time-efficient germ cell transplantation from goldfish (Carassius auratus) into adult common carp (Cyprinus carpio) Timeefficient Time efficient Carassius auratus Cyprinus carpio
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Vigoya, Angel Andreas Arias

; Costa, Daniel Fernandes da

; Oliveira, Marcos Antônio de

; Butzge, Arno Juliano

; Rosa, Ivana Felipe

; Doretto, Lucas Benites

; Martinez, Emanuel Ricardo Monteiro

; Digmayer, Melanie

; Nóbrega, Rafael Henrique

Animal Reproduction

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2024, Volume 21 Nº 1 elocation e20230121

Resumo: En | Texto: En | PDF: En

Abstract Germ cell transplantation in fish is a promising technique for surrogate broodstock parents with broader application in aquaculture and conserving endangered and valuable genetic resources. Herein, we describe the establishment of an intrapapillary xenogeneic transplant of germ cells from sexually mature goldfish (C. auratus) males into common carp (C. carpio) males cytoablated with a thermochemical treatment (two doses of busulfan at 40 mg/kg at 35°C). To analyze the presence and development of donor germ cells in recipient testes, donor germ cells were labeled with PKH26, a fluorescent cell membrane dye, before transplantation. Our results demonstrated that thermochemical treatment caused effective spermatogenesis suppression and pronounced germ cell loss. Moreover, transplanted spermatogonial cells were able to colonize the recipients’ testes, resume spermatogenesis, and generate spermatozoa within eight weeks after germ cell transplantation. These findings suggested that recipient testes provided suitable conditions for the survival, colonization, proliferation, and differentiation of donor spermatogonia from a related species. This study indicated that recipients’ testes exhibited a high degree of plasticity to accept and support xenogeneic donor germ cells, which were able to form sperm in a short time frame. This approach has significant implications for assisted animal reproduction, biotechnology, conservation, and the production of valuable genetic resources and endangered fish species. Herein C. C (C auratus carpio two 4 mgkg mg kg 35°C. 35C 35°C . 35 35°C) PKH26 PKH dye loss Moreover recipients survival colonization proliferation species frame reproduction biotechnology conservation 3 PKH2

https://doi.org/10.1590/1984-3143-ar2023-0121

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Glossário e ajuda para busca

Você pode enriquecer sua busca de uma forma muito simples. Use os índices de pesquisa combinados com os conectores (AND ou OR) e especifique cada vez mais sua busca.

Por exemplo, se você deseja buscar artigos sobre
casos de dengue no Brasil em 2015, use:
ti:dengue and publication_year:2015 and aff_country:Brasil

Veja abaixo a lista completa de índices de pesquisa que podem ser usados:

Cód. do Índice	Elemento
ti	título do artigo
au	autor
kw	palavras-chave do artigo
subject	assunto (palavras do título, resumo e palavras-chave)
ab	resumo
ta	título abreviado da revista (ex. Cad. Saúde Pública)
journal_title	título completo da revista (ex. Cadernos de Saúde Pública)
la	código do idioma da publicação (ex. pt - Português, es - Espanhol)
type	tipo do documento
pid	identificador da publicação
publication_year	ano de publicação do artigo
sponsor	financiador
aff_country	código do país de afiliação do autor
aff_institution	instituição de afiliação do autor
volume	volume do artigo
issue	número do artigo
elocation	elocation
doi	número DOI
issn	ISSN da revista
in	código da coleção SciELO (ex. scl - Brasil, col - Colômbia)
use_license	código da licença de uso do artigo

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Email: scielo@scielo.org

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