ABSTRACT The COVID-19 pandemic has imposed itself in a acutely and dramatically way, particularly on politically and socially vulnerable groups, such as the homeless population (HP). The literature on health emergency and response and social care needs of the most vulnerable during the pandemic is scarce. This article describes the network of care for HP, including formally instituted pathways of care and those produced during the pandemic of COVID-19, in the city of Belo Horizonte. The methodological path used documentary analysis, technical visits to care services, in-depth interviews and focus groups with the care network stakeholders. The results showed that the network is composed of four components with intersections: the health network, the social care network, the ‘National Pastoral Care of the Homeless People’ (non-governmental organization) and the network created to care for people with respiratory symptoms. The workflow changes imposed by the pandemic resulted in access barriers in different centers offering care for HP. However, it was observed the potentiality of the integral care offer, through the connections built during the pandemic between health, social care, and the non-governmental organizations. COVID19 COVID 19 COVID-1 way HP . (HP) scarce COVID19, 19, Horizonte analysis services indepth depth stakeholders intersections National People nongovernmental non governmental organization symptoms However offer organizations COVID1 1 COVID- (HP

RESUMO A pandemia de covid-19 se impôs de modo mais agudo e dramático aos grupos políticos e socialmente mais vulnerabilizados, como a População em Situação de Rua (PSR). A literatura sobre as respostas às demandas de saúde e de assistência social dos mais vulnerabilizados, durante a pandemia, ainda é escassa. Neste artigo, descreve-se a rede de cuidado à PSR, considerando os caminhos formalmente instituídos e aqueles produzidos durante a pandemia de covid-19, no município de Belo Horizonte. Para tanto, realizaram-se análise documental, visitas técnicas a serviços assistenciais, entrevistas em profundidade e grupos focais com atores que compõem a rede de cuidado. Os resultados mostraram que a rede é composta por quatro componentes com interseções: pela rede da saúde, da assistência social, da Pastoral Nacional do Povo da Rua (sociedade civil organizada) e a rede criada para cuidado de sintomáticos respiratórios. As mudanças de fluxos impostas pela pandemia repercutiram em dificuldades no acesso aos serviços de cuidado da PSR. Contudo, observou-se a potencialidade para a oferta da integralidade do cuidado, mediante articulações realizadas na pandemia entre a saúde, a assistência social e a sociedade civil organizada. covid19 covid 19 covid-1 vulnerabilizados PSR . (PSR) escassa artigo descrevese descreve covid19, 19, Horizonte tanto realizaramse realizaram documental assistenciais interseções organizada respiratórios Contudo observouse observou covid1 1 covid- (PSR

Resumo Objetivou-se identificar fatores associados à atenção à saúde infantil na atenção primária à saúde (APS), na perspectiva das ações preconizadas pela Rede de Cuidados à Pessoa Deficiência (RCPCD), quanto à identificação precoce de deficiências e acompanhamento do desenvolvimento infantil. Trata-se de estudo transversal, multicêntrico, realizado em oito estados brasileiros. A coleta de dados envolveu a aplicação de questionário estruturado com profissionais de saúde de nível superior atuantes na APS, com amostra aleatória estratificada por estado e município. Foram realizadas regressões de Poisson com variância robusta para duas variáveis resposta. Entre os 1.488 trabalhadores que compuseram a amostra final, 63,6% realizam ações de identificação precoce de deficiências e 49% efetuam acompanhamento do desenvolvimento infantil. As equipes de Saúde da Família (eSF) identificam e acompanham mais do que as equipes do modelo tradicional, e os Núcleos Ampliados de Saúde da Família e Atenção Básica realizam mais ações de acompanhamento do que essas equipes. Conclui-se que os fatores mais associados com a identificação e o acompanhamento de crianças com deficiências na APS foram aqueles relativos à formação profissional, à eSF e ao conhecimento de normativas relativas à RCPCD. Objetivouse Objetivou se , (APS) RCPCD, RCPCD (RCPCD) Tratase Trata transversal multicêntrico brasileiros município resposta 1488 1 488 1.48 final 636 63 6 63,6 49 (eSF tradicional Concluise Conclui profissional (APS (RCPCD 148 48 1.4 63, 4 14 1.

Abstract The aim of this study was to identify factors associated with early identification of disabilities and developmental follow-up of children in primary health care (PHC) services under the Care Network for People with Disabilities (RCPCD). We conducted a cross-sectional study using data from a multicenter study undertaken in eight states. The data were collected using a structured questionnaire answered by PHC professionals with degree-level qualifications selected using random sampling and stratified by state and municipality. Poisson regression with robust variance was performed for the two outcomes. Of the 1,488 workers in the final sample, 63.6% performed early identification of disabilities and 49% provided developmental follow-up. Family health teams performed early identification of disabilities and follow-up more than traditional model teams, and expanded family health teams provided developmental follow-up more than both these teams. The factors that showed the strongest association with identification and developmental follow-up were profession, working in a family health team and knowledge of the RCPCD. followup follow up (PHC RCPCD . (RCPCD) crosssectional cross sectional states degreelevel degree level municipality outcomes 1488 1 488 1,48 sample 636 63 6 63.6 49 followup. up. profession (RCPCD 148 48 1,4 63. 4 14 1,

Abstract Objective: To investigate the effectiveness of linezolid and vancomycin for the treatment of nosocomial infections in children under 12 years old. Data sources: This is a systematic review in which five randomized clinical trials about the effectiveness of linezolid and vancomycin, involving a total of 429 children with nosocomial infections, were evaluated. They were searched in scientific databases: PubMed, Bvs, and SciELO. Summary of findings: The main nosocomial infections that affected children were bacteremia, skin, and soft tissue infections followed by nosocomial pneumonia. Most infections were caused by Gram-positive bacteria, which all studies showed infections caused by Staphylococcus aureus, with methicillin-resistant S. aureus (MRSA) and methicillin-resistant coagulase-negative staphylococci strains being isolated. Both linezolid and vancomycin showed high therapeutic efficacy against different types of nosocomial infections, ranging from 84.4% to 94% for linezolid and 76.9% to 90% for vancomycin. Patients receiving linezolid had lower rates of rash and red man syndrome compared to those receiving vancomycin. However, despite the adverse reactions, antimicrobials can be safely administered to children to treat nosocomial infections caused by resistant Gram-positive bacteria. Conclusion: Both linezolid and vancomycin showed good efficacy in the treatment of bacterial infections caused by resistant Gram-positive bacteria in hospitalized children. However, linezolid stands out regarding its pharmacological safety. Importantly, to strengthen this conclusion, further clinical trials are needed to provide additional evidence. Objective 1 old sources 42 evaluated databases PubMed Bvs SciELO findings bacteremia skin pneumonia Grampositive Gram positive methicillinresistant methicillin S MRSA (MRSA coagulasenegative coagulase negative isolated 844 84 4 84.4 94 769 76 9 76.9 90 However reactions Conclusion safety Importantly conclusion evidence 8 84. 7 76.

Abstract Landau-Kleffner syndrome (LKS) is an epilepsy syndrome of childhood, characterized by auditory verbal agnosia and severe electroencephalographic abnormalities. It happens between 3-7 years of age, 20% without seizures. A 6-years-old boy, with normal psychomotor development, who begins to experience difficulties in understanding the meaning of words, sometimes with incoherent speech and writing difficulties (irregular handwriting, spelling mistakes). Neurological evaluation showed loss of comprehensive language with auditory verbal agnosia, difficulties in fine motor skills and in graphomotor coordination. After clinical suspicion, the diagnosis of SLK was confirmed by night video-electroencephalogram (EEG): abundant paroxysmal activity of bilateral and independent fronto-center-temporal spikes and spike-wave activity, with an almost continuous exacerbation during sleep. Initially treated with valproate and clobazam, without improvement, he started prednisolone, with improvement in language, writing and normalization of the EEG. Knowledge of this syndrome is important for differential diagnosis with other neurological disorders, especially learning difficulties.

Resumo Síndrome de Landau-Kleffner (SLK) é uma epilepsia da idade pediátrica, caracterizada por agnosia verbal auditiva e alteração eletroencefalográfica grave. Manifesta-se entre 3-7 anos de idade, 20% sem convulsões. Rapaz de 6 anos, normal desenvolvimento psicomotor, inicia dificuldades de compreensão do significado das palavras, por vezes com discurso incoerente e dificuldades de novo da escrita (caligrafia irregular, erros ortográficos). Na avaliação neurológica com perda de linguagem compreensiva com agnosia verbal auditiva, dificuldades de motricidade fina e coordenação grafo-motora. Após suspeição clínica, o diagnóstico de SLK foi confirmado pelo vídeo-eletroencefalograma (EEG) noturno: abundante atividade paroxística de pontas e ponta-onda fronto-centro-temporal bilaterais e independentes, exacerbada no sono, de forma quase contínua. Inicialmente medicado com ácido valpróico e clobazam, sem melhoria, iniciou prednisolona, com melhoria da linguagem, escrita e normalização do EEG. É importante o conhecimento desta síndrome para diagnóstico diferencial com outras perturbações neurológicas, especialmente as dificuldades de aprendizagem específica.

Abstract Background: Psoriasis is associated with several comorbidities and its association with thyroid abnormality has been hypothesized. Objective: To assess the prevalence of thyroid abnormality in Brazilian patients with psoriasis and to analyze its association with severity, presence of psoriatic arthritis and immunobiological treatment. Additionally, to compare results with literature as a control. Methods: In this observational study, clinical and laboratory data of patients followed from January 2018 to December 2019 were analyzed. Thyroid abnormality was assessed through the current history of thyroid disease and laboratory tests – thyrotropin (TSH), free thyroxine (FT4), antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-TG) antibodies. Patients were classified according to psoriasis severity – Psoriasis Area and Severity Index (PASI), presence of psoriatic arthritis, and current treatment. Subsequently, the results were compared with a control group selected from the literature review. Results: Of the 250 included patients, 161 were eligible. The prevalence of thyroid abnormality was 28.57% and of hypothyroidism, 14.91%. The mean age was 55 years and the median PASI was 2.2. There was no association between thyroid abnormality and PASI (p = 0.8), presence of psoriatic arthritis (p = 0.87), or use of immunobiological therapy (p = 0.13). The literature control group included 6,227 patients and there was a statistically significant difference for the hypothyroidism variable (p < 0.0001). Background hypothesized Objective treatment Additionally Methods study 201 analyzed TSH, TSH , (TSH) FT4, FT4 FT (FT4) antiTPO anti TPO (anti-TPO antiTG TG (anti-TG antibodies PASI, (PASI) Subsequently review Results 25 16 eligible 2857 28 57 28.57 1491 14 91 14.91% 5 22 2 2.2 p 0.8, 08 0.8 0 8 0.8) 0.87, 087 0.87 87 0.87) 0.13. 013 0.13 . 13 0.13) 6227 6 227 6,22 0.0001. 00001 0.0001 0001 0.0001) 20 (TSH (FT4 (PASI 1 285 28.5 149 9 14.91 2. 0. 01 0.1 622 6,2 0000 0.000 000 (FT 28. 14.9 62 6, 0.00 00 14. 0.0

Abstract In the modern world, cancer is a growing cause of mortality, but archeological studies have shown that it is not exclusive to modern populations. The aim of this study is to examine the epidemiologic, social, and clinicopathologic features of head and neck cancers in ancient populations. To do this, we extracted all records that described malignant lesions in the head and neck region available in the Cancer Research in Ancient Bodies Database (CRAB). The estimated age, sex, physical condition of the remains (skeletonized, mummified), anatomic location of tumors, geographic location, chronology, tumor type, and methods of tumor diagnosis were collected. One hundred and sixty-seven cases were found, mostly originating from Europe (51.5%). Most records were of adults between 35 and 49 years of age (37.7%). The most involved site was the skullcap (60.4%), and the most common malignancies were metastases to the bone (65.3%) and multiple myeloma (17.4%). No primary soft tissue malignancies were registered. The results of our study indicate that head and neck cancers were present in ancient civilizations, at least since 500,000 BCE. The available data can help to improve the current understanding of the global distribution of head and neck cancer and its multidimensional impacts on populations in the contemporary world. world mortality epidemiologic social CRAB. CRAB . (CRAB) sex skeletonized, skeletonized (skeletonized mummified, mummified , mummified) tumors chronology type collected sixtyseven sixty seven found 51.5%. 515 51.5% 51 5 (51.5%) 3 4 37.7%. 377 37.7% 37 7 (37.7%) 60.4%, 604 60.4% 60 (60.4%) 65.3% 653 65 (65.3% 17.4%. 174 17.4% 17 (17.4%) registered civilizations 500000 500 000 500,00 BCE (CRAB 51.5 (51.5% 37.7 (37.7% 60.4 6 (60.4% 65.3 (65.3 17.4 1 (17.4% 50000 50 00 500,0 51. (51.5 37. (37.7 60. (60.4 65. (65. 17. (17.4 5000 0 500, (51. (37. (60. (65 (17. (51 (37 (60 (6 (17 (5 (3 ( (1

ABSTRACT BACKGROUND: Respiratory failure is the most common cause of death in patients with amyotrophic lateral sclerosis (ALS), and morbidity is related to poor quality of life (QOL). Non-invasive ventilation (NIV) may be associated with prolonged survival and QOL in patients with ALS. OBJECTIVES: To assess whether NIV is effective and safe for patients with ALS in terms of survival and QOL, alerting the health system. DESIGN AND SETTING: Systematic review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting standards using population, intervention, comparison, and outcome strategies. METHODS: The Cochrane Library, CENTRAL, MEDLINE, LILACS, EMBASE, and CRD databases were searched based on the eligibility criteria for all types of studies on NIV use in patients with ALS published up to January 2022. Data were extracted from the included studies, and the findings were presented using a narrative synthesis. RESULTS: Of the 120 papers identified, only 14 were related to systematic reviews. After thorough reading, only one meta-analysis was considered eligible. In the second stage, 248 studies were included; however, only one systematic review was included. The results demonstrated that NIV provided relief from the symptoms of chronic hypoventilation, increased survival, and improved QOL compared to standard care. These results varied according to clinical phenotype. CONCLUSIONS: NIV in patients with ALS improves the outcome and can delay the indication for tracheostomy, reducing expenditure on hospitalization and occupancy of intensive care unit beds. SYSTEMATIC REVIEW REGISTRATION: PROSPERO database: CRD42021279910 — https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=279910. BACKGROUND ALS, , (ALS) QOL. . (QOL) Noninvasive Non invasive (NIV OBJECTIVES system SETTING MetaAnalyses Meta Analyses population intervention comparison strategies METHODS Library CENTRAL MEDLINE LILACS EMBASE 2022 synthesis RESULTS 12 identified 1 reviews reading metaanalysis meta analysis eligible stage 24 however hypoventilation phenotype CONCLUSIONS tracheostomy beds REGISTRATION database CRD4202127991 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=279910. httpswwwcrdyorkacukprosperodisplayrecordphpRecordID279910 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID https //www.crd.york.ac.uk/prospero/display_record.php RecordID=279910. www crd york ac uk prospero display record php RecordID 279910 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=279910 (ALS (QOL 202 2 CRD420212799 phpRecordID https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=279910 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID27991 wwwcrdyorkacukprosperodisplayrecordphp RecordID279910 RecordID=279910 27991 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=27991 20 CRD42021279 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=27991 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID2799 RecordID27991 RecordID=27991 2799 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=2799 CRD4202127 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=2799 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID279 RecordID2799 RecordID=2799 279 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=279 CRD420212 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=279 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID27 RecordID279 RecordID=279 27 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=27 CRD42021 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=27 httpswwwcrdyorkacukprosperodisplayrecordphpRecordID2 RecordID27 RecordID=27 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=2 CRD4202 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID=2 RecordID2 RecordID=2 https://www.crd.york.ac.uk/prospero/display_record.php?RecordID= CRD420 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID= RecordID= https://www.crd.york.ac.uk/prospero/display_record.php?RecordID CRD42 https//www.crd.york.ac.uk/prospero/display_record.phpRecordID CRD4

Resumo Considerando a instituição da Rede de Atenção à Pessoa com Deficiência (RCPD) no Brasil, o estudo analisa a distribuição espacial e a tendência temporal da implantação de serviços especializados que receberam apoio financeiro nos primeiros oito anos dessa política. Realizamos um estudo ecológico com base nos dados do Cadastro Nacional de Estabelecimentos de Saúde no período de abril/2012 a março/2020. Uma regressão joinpoint foi usada para análise de tendência temporal e mapas temáticos foram produzidos para análise espacial de modalidades de reabilitação e tipos de serviços. Os serviços mais disponíveis foram reabilitação física e intelectual. As regiões Sudeste e Nordeste apresentaram maior concentração de serviços especializados. Apesar do menor número de serviços, houve crescimento médio anual entre 9,6% e 41,3%. Esse achado indica aumento de serviços especializados para pessoas com deficiência no período analisado, mas ainda se verificam lacunas assistenciais nas macrorregiões do Brasil.

Abstract Considering the institution of the Care Network for People with Disabilities (RCPD) in Brazil, this study analyzed the spatial distribution and the temporal trend of implementing specialized services that received financial support in the first eight years of this policy. We realized an ecological study based on the National Register of Health Facilities data from April/2012 to March/2020. A joinpoint regression was used for temporal trend analysis, and thematic maps were produced for spatial analysis of rehabilitation modalities and types of services. The most available services were physical and intellectual rehabilitation. The Southeast and Northeast regions had a higher concentration of specialized services. Despite the lower number of services, there was an average annual growth between 9.6% and 41.3%. This finding indicates an increase in specialized services for people with disabilities in the period analyzed, but care gaps are still being verified in the macro-regions of Brazil.

RESUMO A pandemia de covid-19 se impôs de modo mais agudo e dramático aos grupos políticos e socialmente mais vulnerabilizados, como a População em Situação de Rua (PSR). A literatura sobre as respostas às demandas de saúde e de assistência social dos mais vulnerabilizados, durante a pandemia, ainda é escassa. Neste artigo, descreve-se a rede de cuidado à PSR, considerando os caminhos formalmente instituídos e aqueles produzidos durante a pandemia de covid-19, no município de Belo Horizonte. Para tanto, realizaram-se análise documental, visitas técnicas a serviços assistenciais, entrevistas em profundidade e grupos focais com atores que compõem a rede de cuidado. Os resultados mostraram que a rede é composta por quatro componentes com interseções: pela rede da saúde, da assistência social, da Pastoral Nacional do Povo da Rua (sociedade civil organizada) e a rede criada para cuidado de sintomáticos respiratórios. As mudanças de fluxos impostas pela pandemia repercutiram em dificuldades no acesso aos serviços de cuidado da PSR. Contudo, observou-se a potencialidade para a oferta da integralidade do cuidado, mediante articulações realizadas na pandemia entre a saúde, a assistência social e a sociedade civil organizada.

ABSTRACT The COVID-19 pandemic has imposed itself in a acutely and dramatically way, particularly on politically and socially vulnerable groups, such as the homeless population (HP). The literature on health emergency and response and social care needs of the most vulnerable during the pandemic is scarce. This article describes the network of care for HP, including formally instituted pathways of care and those produced during the pandemic of COVID-19, in the city of Belo Horizonte. The methodological path used documentary analysis, technical visits to care services, in-depth interviews and focus groups with the care network stakeholders. The results showed that the network is composed of four components with intersections: the health network, the social care network, the ‘National Pastoral Care of the Homeless People’ (non-governmental organization) and the network created to care for people with respiratory symptoms. The workflow changes imposed by the pandemic resulted in access barriers in different centers offering care for HP. However, it was observed the potentiality of the integral care offer, through the connections built during the pandemic between health, social care, and the non-governmental organizations.

ABSTRACT This paper aimed to map population surveys that identify data on domestic, intra-family, intimate partner and sexual violence, including approaches to sexual behavior and sexual and gender diversity. This is a scoping review that follows the guidelines of the Joanna Briggs Institute and the PRISMA checklist. The search was carried out from December 2021 to April 2022 in the LILACS and Medline databases, Brazilian Digital Library of Theses and Dissertations for gray literature, and extended to 18 sources among websites and institutions relevant to the theme. Out of the 1,191 publications retrieved, 57 were included. Most of the surveys were conducted in Brazil, Portugal and the United States, with a recent increase in the last two decades. The studies focused mainly on domestic or sexual violence and obtained data by means of face-to-face interviews. It is clear that variables such as risk and protective factors, predictors and social determinants of violence are still underexplored in surveys, limiting the understanding of the matter. This review can support the planning of new research and subsequent prevention actions, evaluation of health services and interventions, as well as the fulfillment of public policies to manage the social and individual burden imposed on victims of violence. intrafamily, intrafamily intra family, family intra-family diversity checklist 202 databases literature 1 theme 1191 191 1,19 retrieved 5 included Brazil States decades facetoface face interviews factors matter actions interventions 20 119 19 1,1 2 11 1,

RESUMO O artigo teve como objetivo mapear inquéritos populacionais que identificam dados sobre violências domésticas, intrafamiliares, por parceiro íntimo e sexual, incluindo abordagens sobre comportamento sexual e diversidade sexual e de gênero. Realizou-se uma revisão de escopo conforme as diretrizes do JBI e do checklist PRISMA-ScR. A busca foi conduzida de dezembro de 2021 a abril de 2022 nas bases de dados Lilacs e Medline, Biblioteca Digital Brasileira de Teses e Dissertações para a literatura cinzenta, e extensiva a 18 fontes, dentre sites e instituições pertinentes ao tema. Das 1.191 publicações recuperadas, 57 fizeram parte da amostra final. A maior parte dos inquéritos foi conduzida no Brasil, Portugal e Estados Unidos. Os estudos focaram, principalmente, na violência doméstica ou sexual, sendo seus dados obtidos por entrevista presencial. Percebe-se que variáveis como fatores de risco e proteção, preditores e determinantes sociais de violência ainda são pouco exploradas nos inquéritos, limitando a compreensão do fenômeno. A revisão aqui relatada pode subsidiar o planejamento de novas pesquisas e subsequentes ações de prevenção, avaliação de serviços e de intervenções em saúde, bem como a implantação de políticas públicas de manejo da carga social e individual impostas às vítimas de violência. domésticas intrafamiliares gênero Realizouse Realizou se PRISMAScR. PRISMAScR PRISMA ScR. ScR PRISMA-ScR 202 Medline cinzenta 1 fontes tema 1191 191 1.19 recuperadas 5 final Brasil Unidos focaram principalmente presencial Percebese Percebe proteção fenômeno prevenção saúde 20 119 19 1.1 2 11 1.

ABSTRACT Objective: The purpose of this study was to assess performance in the Brazilian Lung Cancer Registry Database by using the parsimonious EuroLung risk models for morbidity and mortality. Methods: The EuroLung1 and EuroLung2 models were tested and evaluated through calibration (calibration plot, Brier score, and the Hosmer-Lemeshow test) and discrimination (ROC AUCs), in a national multicenter registry of 1,031 patients undergoing anatomic lung resection. Results: The evaluation of performance in Brazilian health care facilities utilizing risk-adjustment models, specifically EuroLung1 and EuroLung2, revealed substantial miscalibration, as evidenced by calibration plots and Hosmer-Lemeshow tests in both models. In terms of calibration, EuroLung1 exhibited a calibration plot with overlapping points, characterized by a slope of 1.11 and a Brier score of 0.15; the Hosmer-Lemeshow test yielded a statistically significant p-value of 0.015; and the corresponding ROC AUC was 0.678 (95% CI: 0.636-0.721). The EuroLung2 model displayed better calibration, featuring fewer overlapping points in the calibration plot, with a slope of 1.22, with acceptable discrimination, as indicated by a ROC AUC of 0.756 (95% CI: 0.670-0.842). Both models failed to accurately predict morbidity and mortality outcomes in this specific health care context. Conclusions: Discrepancies between the EuroLung model predictions and outcomes in Brazil underscore the need for model refinement and for a probe into inefficiencies in the Brazilian health care system. Objective Methods HosmerLemeshow Hosmer Lemeshow AUCs, AUCs , AUCs) 1031 1 031 1,03 resection Results riskadjustment adjustment miscalibration 111 11 1.1 0.15 015 0 15 pvalue p value 0.015 0015 0678 678 0.67 95% 95 (95 CI 0.6360.721. 06360721 0.636 0.721 . 636 721 0.636-0.721) 122 22 1.22 0756 756 0.75 0.6700.842. 06700842 0.670 0.842 670 842 0.670-0.842) context Conclusions system 103 03 1,0 1. 0.1 01 0.01 001 067 67 0.6 9 (9 6360 0.6360.721 0636072 0636 0.63 0721 0.72 63 72 0.636-0.721 12 2 1.2 075 75 0.7 6700 0.6700.842 0670084 0670 0842 0.84 84 0.670-0.842 10 1, 0. 0.0 00 06 6 ( 0.6360.72 063607 063 072 7 0.636-0.72 07 0.6700.84 067008 084 0.8 8 0.670-0.84 0.6360.7 06360 0.636-0.7 0.6700.8 06700 08 0.670-0.8 0.6360. 0.636-0. 0.6700. 0.670-0. 0.6360 0.636-0 0.6700 0.670-0 0.636- 0.670-

RESUMEN Objetivo: Realizar la adaptación transcultural de CALCULATE al portugués brasileño. Método: Un estudio metodológico llevado a cabo de enero a diciembre de 2021, dividido en seis etapas: traducción, síntesis, retrotraducción, comité de expertos con aplicación del índice de validez de contenido, preprueba en 40 pacientes adultos y envío a las autoras. El estudio se realizó en las unidades de cuidados intensivos de un hospital público de enseñanza terciaria en el interior del estado de São Paulo, Brasil. El CALCULATE original tiene ocho ítems de evaluación (factores de riesgo) y se estratifica con un puntaje de 0-3 (alto riesgo) y 4-8 (riesgo muy alto). Resultados: Después de la evaluación de los expertos, la validez de contenido final fue de 0,9. Sugirieron palabras y frases que debían cambiar en cuanto a equivalencias textuales, así como definiciones de siglas y terminologías. En la preprueba, los ítems se evaluaron como adecuados para la comprensión; solo un ítem requirió una explicación adicional para su adecuación. Conclusión: Se realizó con éxito la adaptación transcultural de CALCULATE al portugués brasileño, revelando un buen índice de validez de contenido, confirmando la relevancia y adecuación de sus ítems. CALCULATE es adecuado para su uso en unidades de cuidados intensivos y centros de investigación y enseñanza. Objetivo brasileño Método 2021 etapas traducción síntesis retrotraducción 4 autoras Paulo Brasil factores riesgo 03 0 3 0- alto 48 8 4- alto. . alto) Resultados 09 9 0,9 textuales terminologías comprensión Conclusión 202 0, 20 2

ABSTRACT Objective: To perform the cross-cultural adaptation of CALCULATE for Brazilian Portuguese. Method: A methodological study conducted from January to December 2021, divided into six stages: translation, synthesis, back-translation, expert committee with the application of the content validity index, pre-testing in 40 adult patients, and submission to the authors. The study took place in the intensive care units of a public tertiary teaching hospital in the interior of the state of São Paulo, Brazil. The original CALCULATE has eight risk assessment items and is stratified with a score of 0-3 (high risk) and 4-8 (very high risk). Results: After expert evaluation, the final content validity was 0.9. They suggested words and phrases that should undergo changes regarding textual equivalences, as well as definitions of acronyms and terminologies. In the pre-test, the items were assessed as suitable for understanding; only one item required additional explanation for adequacy. Conclusion: The cross-cultural adaptation of CALCULATE for Brazilian Portuguese was successfully performed, revealing a good content validity index, confirming the relevance and appropriateness of its items. CALCULATE is suitable for use in intensive care units and research and teaching centers. Objective crosscultural cross cultural Method 2021 stages translation synthesis backtranslation, backtranslation back back-translation index pretesting pre testing 4 patients authors Paulo Brazil 03 0 3 0- 48 8 4- very risk. . Results evaluation 09 9 0.9 equivalences terminologies pretest, pretest test, test pre-test understanding adequacy Conclusion performed centers 202 0. 20 2

RESUMO Objetivo: Realizar a adaptação transcultural do CALCULATE para o português brasileiro. Método: Estudo metodológico, desenvolvido de janeiro a dezembro de 2021 e dividido em seis etapas: tradução, síntese, retrotradução, comitê de especialistas com aplicação de índice de validade de conteúdo, pré-teste em 40 pacientes adultos e envio às autoras. O estudo ocorreu nas unidades de terapia intensiva em hospital público de ensino de nível terciário no interior do estado de São Paulo, Brasil. O CALCULATE original tem oito itens de avaliação (fatores de risco) e é estratificado com escore 0-3 (alto risco) e 4-8 (risco muito alto). Resultados: Após avaliação dos especialistas, a validade de conteúdo final foi de 0,9. Eles sugeriram palavras e frases que deveriam sofrer alterações quanto às equivalências textuais, assim como definições de siglas e terminologias. No pré-teste, os itens foram avaliados como adequados na compreensão; apenas um item precisou de explicação complementar para adequação. Conclusão: Foi realizada a adaptação transcultural do CALCULATE para o português do Brasil, a qual revelou ter bom índice de validade de conteúdo, sendo verificada a pertinência e relevância de seus itens. O CALCULATE está adequado para utilização em unidades de terapia intensiva e centros de pesquisa e ensino. Objetivo brasileiro Método metodológico 202 etapas tradução síntese retrotradução préteste pré teste 4 autoras Paulo Brasil fatores risco 03 0 3 0- alto 48 8 4- alto. . alto) Resultados 09 9 0,9 textuais terminologias préteste, teste, compreensão adequação Conclusão 20 0, 2

Resumo Objetivou-se identificar fatores associados à atenção à saúde infantil na atenção primária à saúde (APS), na perspectiva das ações preconizadas pela Rede de Cuidados à Pessoa Deficiência (RCPCD), quanto à identificação precoce de deficiências e acompanhamento do desenvolvimento infantil. Trata-se de estudo transversal, multicêntrico, realizado em oito estados brasileiros. A coleta de dados envolveu a aplicação de questionário estruturado com profissionais de saúde de nível superior atuantes na APS, com amostra aleatória estratificada por estado e município. Foram realizadas regressões de Poisson com variância robusta para duas variáveis resposta. Entre os 1.488 trabalhadores que compuseram a amostra final, 63,6% realizam ações de identificação precoce de deficiências e 49% efetuam acompanhamento do desenvolvimento infantil. As equipes de Saúde da Família (eSF) identificam e acompanham mais do que as equipes do modelo tradicional, e os Núcleos Ampliados de Saúde da Família e Atenção Básica realizam mais ações de acompanhamento do que essas equipes. Conclui-se que os fatores mais associados com a identificação e o acompanhamento de crianças com deficiências na APS foram aqueles relativos à formação profissional, à eSF e ao conhecimento de normativas relativas à RCPCD.

Abstract The aim of this study was to identify factors associated with early identification of disabilities and developmental follow-up of children in primary health care (PHC) services under the Care Network for People with Disabilities (RCPCD). We conducted a cross-sectional study using data from a multicenter study undertaken in eight states. The data were collected using a structured questionnaire answered by PHC professionals with degree-level qualifications selected using random sampling and stratified by state and municipality. Poisson regression with robust variance was performed for the two outcomes. Of the 1,488 workers in the final sample, 63.6% performed early identification of disabilities and 49% provided developmental follow-up. Family health teams performed early identification of disabilities and follow-up more than traditional model teams, and expanded family health teams provided developmental follow-up more than both these teams. The factors that showed the strongest association with identification and developmental follow-up were profession, working in a family health team and knowledge of the RCPCD.