Resumo Objetivo O objetivo deste estudo foi avaliar a prevalência da radiolucência justa-apical (RJA) e sua relação com estruturas adjacentes por meio da tomografia computadorizada de feixe cônico (TCFC). Material e método Exames de TCFC foram analisados a partir de um banco de dados de 2017 a 2021 de pacientes adultos com terceiros molares inferiores para avaliação da presença de RJA. Os terceiros molares associados a RJA foram classificados de acordo com a profundidade de impactação, angulação e desenvolvimento radicular. A RJA também foi classificada de acordo com sua relação com o canal mandibular e sua área cortical, tamanho e localização. Resultado 1.097 exames de TCFC foram coletados do banco de dados durante o período de avaliação e, após a aplicação dos critérios de elegibilidade, 155 exames foram incluídos na análise. Trinta e um terceiros molares apresentaram presença de RJA com prevalência de 20%. Observou-se que a maioria dos casos eram unilaterais (84%), localizados mesialmente (53%), e de tamanho médio (53%), em contato com o canal mandibular com presença cortical (50%), visualizados em terceiros molares principalmente mesioangulares (36%), parcialmente intraósseo (86%) e com desenvolvimento radicular completo (92%). Não foram detectadas diferenças entre sexo e idade quanto à presença de RJA. Conclusão Os dados obtidos revelaram alta prevalência de RJA, frequentemente em contato com o canal mandibular, sendo considerado um risco potencial para lesão do nervo alveolar inferior. justaapical justa apical (RJA TCFC. . (TCFC) 201 202 impactação localização 1097 1 097 1.09 elegibilidade 15 análise 20 20% Observouse Observou se 84%, 84 84% , (84%) 53%, 53 53% (53%) 50%, 50 50% (50%) 36%, 36 36% (36%) 86% 86 (86% 92%. 92 92% (92%) inferior (TCFC 109 09 1.0 2 8 (84% 5 (53% (50% 3 (36% (86 9 (92% 10 0 1. (84 (53 (50 (36 (8 (92 (5 (3 ( (9

Abstract Objective The aim of this study was to evaluate juxta-apical radiolucency (JAR) prevalence and its relationship with adjacent structures using cone-beam computed tomography (CBCT). Material and method CBCT scans were analyzed from a database from 2017 to 2021 of adult patients with mandibular third molars to visualize the presence of JAR. Third molars associated with JAR were classified according to impaction depth, angulation, and root development. JAR was also classified according to its relationship with the mandibular canal and its cortical area, size, and location. The chi-square test and the Mann-Whitney Test were performed to compare the age of patients and gender regarding the presence or absence of JAR. Result 1097 CBCT scans were collected from the database during the evaluation period, and after the application of the eligibility criteria, 155 scans were included in the analysis. Thirty-one third molars showed the presence of JAR with a 20% prevalence. Most cases were observed to be unilateral (84%), located mesially (53%), and medium-sized (53%), in contact with the mandibular canal with cortical presence (50%), visualized in third molars mostly mesioangular (36%), partially intraosseous (86%), and with complete root development (92%). No significant differences were detected between gender and age concerning the presence of JAR. Conclusion High JAR prevalence was observed, which was frequently in contact with the mandibular canal, being considered a potential risk for nerve damage. juxtaapical juxta apical (JAR conebeam cone beam CBCT. . (CBCT) 201 202 depth angulation area size location chisquare chi square MannWhitney Mann Whitney 109 period criteria 15 analysis Thirtyone Thirty one 20 84%, 84 84% , (84%) 53%, 53 53% (53%) mediumsized medium sized 50%, 50 50% (50%) 36%, 36 36% (36%) 86%, 86 86% (86%) 92%. 92 92% (92%) damage (CBCT 10 1 2 8 (84% 5 (53% (50% 3 (36% (86% 9 (92% (84 (53 (50 (36 (86 (92 (8 (5 (3 (9 (

Abstract This study aimed to evaluate the potential of strontium ranelate (SR) in medication-related jaw osteonecrosis (MRONJ) after tooth extraction in ovariectomized rats. Thirty ovariectomized rats were divided into three groups (n = 10): bisphophonate (BP) group (zoledronic acid; 0.4 mg/kg/week), SR group (625 mg/kg/day), and control group (saline solution). The lower first molars were extracted after 60 days of drug therapy. Drug administration was continued for another 30 days after tooth extraction. The mandibles were subjected to clinical, histological, radiographic, and microtomographic evaluations. Only the BP group showed clinical changes, characterized by the presence of 70% (n = 7) and 20% (n = 2) of ulcers and extraoral fistulas. Radiographic evaluation demonstrated bone sequestration only in the BP group (n = 7, 70%). Microtomographic analysis revealed increased bone porosity after ovariectomy, particularly in the the control group (p < 0.05). The BP group showed a higher bone surface density, bone volume, and trabecular number than SR and control groups, but with less trabecular separation (p < 0.05). All the animals in the BP group demonstrated histological osteonecrosis. There was no evidence of osteonecrosis in the control and SR groups, which was characterized by the absence of empty osteocyte gaps and associated with the gradual healing of the extraction area. Also, an increased number of blood vessels and a reduced number of osteoclasts were observed in the SR group (p < 0.05). Therefore, SR treatment increased angiogenesis and osteoclastogenesis in the healing socket and was not associated with MRONJ development after tooth extraction in ovariectomized rats.