Abstract At low concentrations used for in-office bleaching gels, such as 6% HP, gingival barrier continues to be performed. If we take into account that, in the at-home bleaching technique, no barrier is indicated, it seems that the use of a gingival barrier fails to make much sense when bleaching gel in low concentration is used for in-office bleaching. Objective This double-blind, split-mouth, randomized clinical trial evaluated the gingival irritation (GI) of in-office bleaching using 6% hydrogen peroxide (HP) with and without a gingival barrier in adolescents, as well as color change and the impact of oral condition on quality of life. Methodology Overall, 60 participants were randomized into which side would or would not receive the gingival barrier. In-office bleaching was performed for 50 minutes with 6% HP in three sessions. The absolute risk and intensity of GI were assessed with a visual analogue scale. Color change was assessed using a digital spectrophotometer and color guides. The impact of oral condition on quality of life was assessed using the Brazilian version of the Oral Health Impact Profile (α=0.05). Results The proportion of patients who presented GI for the “with barrier” group was 31.6% and for the “without barrier” group, 30% (p=1.0). There is an equivalence for the evaluated groups regarding GI intensity (p<0.01). Color change was detected with no statistical differences (p>0.29). There was a significant impact of oral condition on quality of life after bleaching (p<0.001). Conclusions The use or not of the gingival barrier for in-office bleaching with 6% HP was equivalent for GI, as well as for bleaching efficacy, with improvement in the impact of oral condition on quality of life. inoffice office gels 6 athome at home technique indicated doubleblind, doubleblind double blind, blind double-blind splitmouth, splitmouth split mouth, mouth split-mouth (GI (HP adolescents Overall Inoffice In 5 sessions scale guides α=0.05. α005 α α=0.05 . 0 05 (α=0.05) 316 31 31.6 30 p=1.0. p10 p p=1.0 1 (p=1.0) p<0.01. p001 p<0.01 01 (p<0.01) p>0.29. p029 p>0.29 29 (p>0.29) p<0.001. p0001 p<0.001 001 (p<0.001) efficacy α00 α=0.0 (α=0.05 3 31. p1 p=1. (p=1.0 p00 p<0.0 (p<0.01 p02 p>0.2 2 (p>0.29 p000 p<0.00 00 (p<0.001 α0 α=0. (α=0.0 p=1 (p=1. p0 p<0. (p<0.0 p>0. (p>0.2 (p<0.00 α=0 (α=0. p= (p=1 p<0 (p<0. p>0 (p>0. α= (α=0 (p= p< (p<0 p> (p>0 (α= (p (p< (p> (α

Resumo Este estudo in vitro teve como objetivo quantificar a penetração de peróxido de hidrogênio (PH), eficácia clareadora (EC) e toxicidade em larvas em diferentes técnicas de clareamento utilizando 6% de PH. Sessenta pré-molares superiores foram divididos em seis grupos (n = 10): Pola Luminate (PL), VivaStyle Paint On PIus (VS), PolaDay (PD), White Class (WC) e Whiteness HP Automixx (AM). Um grupo não exposto aos agentes clareadores foi avaliado como grupo controle negativo (GC). A concentração inicial de PH nos agentes clareadores foi determinada por meio de titulação e o pH medido com um pHmetro digital. A concentração (µg/mL) de PH no interior da cavidade pulpar foi avaliada por espectrofotometria UV-Vis. A EC (ΔEab * e ΔE00) foi avaliada com um espectrofotômetro digital. A toxicidade foi avaliada em modelo larval. Os dados de penetração de PH e mudança de cor foram avaliados por uma ANOVA de uma via e o teste de Tukey, bem como a curva de morte de Kaplan-Meier para toxicidade (α = 0,05). VS, PD e AM tiveram uma concentração inicial menor do que a relatada pelos fabricantes. VS teve um pH mais ácido. PL e WC apresentaram uma quantidade significativamente menor de PH dentro da cavidade pulpar quando comparados ao VS (p = 0,001). Com relação a EC, não foi observada diferença significativa para ΔEab (p = 0,38) e ΔE00 (p = 0,42). Nenhuma toxicidade foi observada quando todos os 6% PH foram comparados com GC (p > 0,05). Todos os produtos 6% PH testados apresentaram eficácia clareadora, baixa penetração na câmara pulpar e não foram tóxicos para larvas de Tenebrio molitor. PH, , (PH) (EC 6 prémolares pré molares n 10 10) PL, (PL) (VS) PD, (PD) (WC AM. . (AM) GC. (GC) digital µg/mL µgmL µg mL (µg/mL UVVis. UVVis UV Vis. Vis UV-Vis ΔE larval Tukey KaplanMeier Kaplan Meier α 0,05. 005 0,05 0 05 0,05) fabricantes ácido p 0,001. 0001 0,001 001 0,001) 0,38 038 38 ΔE0 0,42. 042 0,42 42 0,42) molitor (PH 1 (PL (VS (PD (AM (GC 00 0,0 000 0,00 0,3 03 3 04 0,4 4 0,

Abstract This in vitro study aimed to quantify the penetration of hydrogen peroxide (HP), bleaching efficacy (BE) and toxicity in larvae in different bleaching techniques using 6% HP. Sixty maxillary premolars were divided in six groups (n = 10): Pola Luminate (PL), VivaStyle Paint On PIus (VS), PolaDay (PD), White Class (WC) and Whiteness HP Automixx (AM). A group not exposed to bleaching agents was evaluated as a control group (CG). Previously, the initial HP concentration in the bleaching agents was determined via titration and pH was measured with a digital pH meter. The concentration (µg/mL) of HP inside the pulp cavity was assessed using UV-Vis spectrophotometry. The BE (ΔE* ab and ΔE00) was evaluated with a digital spectrophotometer. The toxicity was evaluated in larvae model. Data from HP penetration and color change were evaluated for a one-way ANOVA and the Tukey’s test, as well as Kaplan-Meier death curve for toxicity (α = 0.05). VS, PD and AM had an initial concentration lower than that the manufacturers reported. VS had a more acidic pH. PL and WC showed a significantly lower HP amount inside the pulp cavity when compared to VS (p = 0.001). Regarding BE, no significant difference was observed for ΔE* ab (p = 0.38), and ΔE00 (p = 0.42). No toxicity was observed when all 6% HP was compared to GC (p > 0.05). All 6% HP products tested showed bleaching efficacy, low penetration into the pulp chamber and were non-toxic to Tenebrio molitor larvae. HP, , (HP) (BE 6 n 10 10) PL, (PL) (VS) PD, (PD) (WC AM. . (AM) CG. CG (CG) Previously meter µg/mL µgmL µg mL (µg/mL UVVis UV Vis spectrophotometry ΔE (ΔE spectrophotometer model oneway one way Tukeys Tukey s test KaplanMeier Kaplan Meier α 0.05. 005 0.05 0 05 0.05) reported p 0.001. 0001 0.001 001 0.001) 0.38, 038 0.38 38 0.38) ΔE0 0.42. 042 0.42 42 0.42) nontoxic non toxic (HP 1 (PL (VS (PD (AM (CG 00 0.0 000 0.00 03 0.3 3 04 0.4 4 0.

Resumo Embora a literatura tenha observado variações na permeabilidade do peróxido de hidrogênio (PH) e, consequentemente, na sensibilidade dental entre diferentes tipos de dentes anteriores, há escassez de pesquisas sobre esse tema específico. Este estudo teve como objetivo avaliar a permeabilidade do PH e a mudança da cor (MC) em diferentes grupos de dentes anteriores superiores humanos (caninos, incisivos laterais e incisivos centrais) após clareamento de consultório com PH a 35%. Trinta dentes anteriores superiores (n=10) foram clareados com gel de PH a 35% numa sessão de três aplicações de 15 minutos. A espessura vestibular (mm) foi medida em imagens de tomografia computadorizada de feixe cônico. A concentração de HP (µg/mL) na câmara pulpar foi avaliada por espectrofotometria UV-Vis. A MC (WID, ∆Eab e ∆E00) foi avaliada antes e após o clareamento com espectrofotômetro digital. Aplicou-se ANOVA unidirecional e teste de Tukey para avaliar estatisticamente os dados de espessura bucal, permeabilidade PH e MC (α=0,05). A comparação entre espessura versus permeabilidade PH foi realizada com correlação de Pearson. Dentes mais grossos, como os caninos, apresentaram menor quantidade de HP no interior da câmara pulpar do que os incisivos centrais e laterais. Apesar da espessura vestibular afetar significativamente a permeabilidade do PH (p<0,05), não foram encontradas correlações entre ambos os fatores. A MC foi semelhante, independente do tipo de dente (p>0,05). A diferença na espessura vestibular dos dentes anteriores superiores não interfere na MC. Porém, quanto mais fina a espessura da parede vestibular, maior será a permeabilidade do PH detectada na polpa após o clareamento de consultório. (PH consequentemente específico (MC caninos (caninos 35 n=10 n10 n 10 (n=10 1 minutos mm (mm cônico µg/mL µgmL µg mL (µg/mL UVVis. UVVis UV Vis. Vis UV-Vis WID, WID (WID Eab ∆E00 E00 E digital Aplicouse Aplicou se bucal α=0,05. α005 α α=0,05 . 0 05 (α=0,05) Pearson grossos p<0,05, p005 p p<0,05 , (p<0,05) fatores semelhante p>0,05. p>0,05 (p>0,05) Porém 3 n=1 n1 (n=1 ∆E0 E0 α00 α=0,0 (α=0,05 p00 p<0,0 (p<0,05 p>0,0 (p>0,05 n= (n= ∆E α0 α=0, (α=0,0 p0 p<0, (p<0,0 p>0, (p>0,0 (n α=0 (α=0, p<0 (p<0, p>0 (p>0, α= (α=0 p< (p<0 p> (p>0 (α= (p< (p> (α (p

Abstract While the literature has noted variations in hydrogen peroxide (HP) permeability, and consequently, tooth sensitivity among different types of anterior teeth, there is a scarcity of research on this specific topic. This study evaluated HP permeability and color change (CC) in different groups of human maxillary anterior teeth (canines, lateral incisors, and central incisors) after in-office bleaching with HP at 35%. Thirty teeth maxillary anterior (n=10) were bleached with HP at 35% gel in one session of three 15-minutes applications. Buccal thickness (mm) was measured from images obtained using cone beam computed tomography. The concentration of HP (µg/mL) that reached the pulp chamber was assessed using UV-Vis spectrophotometry. CC (WID, ∆Eab, and ∆E00) was evaluated before and after bleaching with a digital spectrophotometer. One-way ANOVA and Tukey’s test were applied to statistically evaluate the data for buccal thickness, HP permeability, and CC (α=0.05). Comparison between thickness and HP permeability was performed using Pearson's correlation. Thicker teeth, such as canines, had lower HP amounts inside the pulp chamber compared to central and lateral incisors. Despite the significant effect of buccal thickness on HP permeability (p<0.05), no correlation was found between the two factors. CC was similar across tooth types (p>0.05). The difference in buccal thickness among the superior anterior teeth does not interfere with CC. However, a thinner buccal wall thickness is associated with greater HP permeability detected in the pulp after in-office bleaching. (HP consequently topic (CC canines (canines incisors inoffice office 35 n=10 n10 n 10 (n=10 15minutes minutes 15 applications mm (mm tomography µg/mL µgmL µg mL (µg/mL UVVis UV Vis spectrophotometry WID, WID (WID Eab ∆Eab ∆E00 E00 E spectrophotometer Oneway One way Tukeys Tukey s α=0.05. α005 α α=0.05 . 0 05 (α=0.05) Pearsons Pearson p<0.05, p005 p p<0.05 , (p<0.05) factors p>0.05. p>0.05 (p>0.05) However 3 n=1 n1 1 (n=1 ∆E0 E0 α00 α=0.0 (α=0.05 p00 p<0.0 (p<0.05 p>0.0 (p>0.05 n= (n= ∆E α0 α=0. (α=0.0 p0 p<0. (p<0.0 p>0. (p>0.0 (n α=0 (α=0. p<0 (p<0. p>0 (p>0. α= (α=0 p< (p<0 p> (p>0 (α= (p< (p> (α (p

Abstract This narrative review critically examines some protocols of biomimetic restorative dentistry (BRD), which supposedly outperforms traditional adhesive techniques. This review explores the origins of BRD, introduces cognitive biases influencing the adoption of BRD protocols without evidence scrutiny, and discusses nine BRD protocols. For this, we searched randomized clinical trials and systematic reviews in the literature on the PubMed, Embase, and Cochrane Library CENTRAL databases, which lead to the following conclusions about the revised protocols: 1) The use of dyes excessively removes carious dentin; 2) Aluminum oxide air abrasion contributes to overtreatment and may pose long-term health risks to dental professionals; 3) Beveling enamel in posterior teeth is technically difficult and leads to unnecessary loss of adjacent sound enamel with no evidence of its use outperforming butt-joint preparations; 4) Deactivating matrix metalloproteinases with chlorhexidine shows no clinical evidence of improving restoration longevity. 5) “Elected“ gold-standard adhesive systems perform no better than other good performing available systems; 6) Immediate dentin sealing and resin coating result in similar post-operative sensitivity and longevity of indirect fillings as delayed dentin sealing; 7) Deep margin elevation is a viable alternative to manage subgingival margins in occlusoproximal cavities; 8) The process of “decoupling” with time lacks scientific evidence to support its use; 9) Placing fiber inserts on the pulpal floor and/or axial wall to minimize stress offers no benefits over current alternatives. In conclusion, more rigorous research is needed to validate BRD protocols, focusing on important clinical outcomes that impact in the longevity of the restoration, such as fracture, debonding, post-operative sensitivity, esthetic quality, presence of caries lesions adjacent to restorations and patients’ satisfaction need to be thoroughly investigated. Reliance on anecdotal evidence, clinical experience, and common sense propagates myths and undervalues the need for a critical approach in evaluating dental techniques. , (BRD) techniques scrutiny this PubMed Embase databases 1 2 longterm long term professionals 3 buttjoint butt joint preparations 4 5 Elected “Elected goldstandard gold standard 6 postoperative post operative 7 cavities 8 decoupling “decoupling 9 andor or alternatives conclusion fracture debonding quality patients investigated experience (BRD

Resumo Este estudo teve como objetivo avaliar os efeitos da aplicação do ascorbato de sódio a 10% (AS) depois do clareamento em consultório na penetração do peróxido do hidrogênio (PH) na câmara pulpar, mudança de cor e resistência de união (RU) da interface resina-esmalte. Trinta pré-molares e trinta molares foram divididos aleatoriamente em três grupos (n = 20). Um grupo foi exposto em água deionizada (controle negativo). Os outros dois grupos foram clareados com 35% PH numa única sessão de 3x15 minutos para cada aplicação. Porém, só um grupo recebeu AS durante 10 minutos depois do clareamento. Depois, a concentração (µg/mL) do PH no interior de cada câmara pulpar foi avaliado com espectrofotometria UV-Vis. A mudança de cor (ΔEab, ΔE00 and ΔWID) foi avaliada como espectrofotômetro digital antes e depois de uma semana do clareamento. Após de cada tratamento, os molares foram restaurados e seccionados em espécimes com interface resina-esmalte para o teste de RU por microtração a uma velocidade de 1 mm/min até a fratura. Os dados da concentração de PH e RU foram analisados usando ANOVA de uma via e teste de Tukey, e a mudança de cor com o teste t (α = 0.05). A aplicação de AS melhorou significativamente a RU e reduziu a concentração de PH na câmara pulpar (p < 0.0001). A aplicação de AS interferiu significativamente na mudança de cor depois do clareamento comprado com o grupo controle (p < 0.05). A aplicação de SA a 10% depois do clareamento em consultório reduziu significativamente a penetração do PH na câmara pulpar e interferiu na mudança de cor. (AS (PH (RU resinaesmalte. resinaesmalte resina esmalte. esmalte prémolares pré n 20. 20 . 20) negativo. negativo negativo) 35 x 3x1 Porém Depois µg/mL µgmL µg mL (µg/mL UVVis. UVVis UV Vis. Vis UV-Vis ΔEab, ΔEab (ΔEab ΔE ΔE0 ΔWID tratamento mmmin mm min fratura Tukey α 0.05. 005 0.05 0 05 0.05) p 0.0001. 00001 0.0001 0001 0.0001) 2 3 3x 00 0.0 0000 0.000 000 0. 0.00

Abstract This study aimed to evaluate the effects of the application of 10% sodium ascorbate (SA) after in-office bleaching on the penetration of hydrogen peroxide (HP) into the pulp chamber, color change, and microtensile bond strength (µTBS) to the resin-enamel interface. Thirty premolars and thirty molars were randomly divided into three groups (n = 20 each). One group was exposed to deionized water (negative control). The other two groups were bleached with 35% HP in a single session for 3x15 minutes for each application. However, in only one of them, SA was applied for 10 minutes after bleaching. After, the concentration (µg/mL) of HP in each pulp chamber was evaluated by UV-Vis spectrophotometry. Color changes (ΔEab, ΔE00, and ΔWID) were evaluated with a digital spectrophotometer before and in the first week after bleaching. After treatment, molars were restored and sectioned to obtain resin-enamel interface sticks for µTBS at a crosshead speed of 1 mm/min until failure. The HP concentration and µTBS data were analyzed using one-way ANOVA and Tukey tests, and color changes were analyzed by t-tests (α = 0.05). SA application significantly improved the µTBS values and reduced the HP concentrations within the pulp chambers (p < 0.0001). The application of SA significantly interfered with the color changes after bleaching when compared to the control group (p < 0.05). Application of 10% SA after in-office bleaching successfully reduced the penetration of HP into the pulp chamber; however, it decreased color change. (SA inoffice office (HP change (µTBS resinenamel resin enamel n 2 each. . each) negative control. control) 35 x 3x1 However them µg/mL µgmL µg mL (µg/mL UVVis UV Vis spectrophotometry ΔEab, ΔEab (ΔEab ΔE00 ΔE ΔWID treatment mmmin mm min failure oneway way tests ttests t α 0.05. 005 0.05 0 05 0.05) p 0.0001. 00001 0.0001 0001 0.0001) however 3 3x ΔE0 00 0.0 0000 0.000 000 0. 0.00

Abstract Despite the availability of in-office bleaching gels with a 6% concentration of hydrogen peroxide (HP), these gels have not been evaluated in younger patients. They are commercially available with a tip, associated or not with a brush, where the tip with a brush spreads the gel over the entire surface to have a smaller thickness (thin layer) since the manufacturers indicate the application of a thin layer of gel. Objective This randomized, split-mouth, double-blind clinical trial evaluated the efficacy of in-office bleaching with 6% HP in adolescents using different application tips, as well tooth sensitivity (TS) and aesthetic self-perception. Methodology Sixty participants were randomized for 6% HP self-mixing bleaching gel tip design: without brush and with brush. In-office bleaching was performed in 3 sessions of 50 minutes. Color change was evaluated using a digital spectrophotometer (ΔE ab , ΔE 00 , and ΔWI D ) and color guide (ΔSGU), the absolute risk and intensity of TS with a visual analogue scale and aesthetic self-perception with the oral aesthetic scale (a=0.05). Results The groups achieved similar bleaching regardless of the application tip (p>0.05). However, only for ΔWI D , a significant mean difference (MD) was observed in the third week (MD 2.3; 95% CI 1.2 to 3.3; p < 0.001) and at one month (MD 1.6; 95% CI 0.6 to 2.6; p < 0.03) favoring the tip without brush. Regarding TS, 45% in the tip-without-brush group and 33% in the tip-with-brush group reported TS (odds ratio 0.61; 95% CI 0.29 to 1.28; p<0.02), with low TS intensity (MD 0.05; 95% CI -0.06 to 0.17; p>0.36). All patients reported improved aesthetic self-perception after bleaching (MD -1.3; 95% -1.8 to -0.9; p<0.001). Conclusions Regardless of the tip used bleaching with 6% HP achieved a bleaching efficacy and improved the aesthetic self-perception. However, a lower risk of TS for application using the tip with brush was observed. inoffice office 6 HP, (HP) splitmouth, splitmouth split mouth, mouth split-mouth doubleblind double blind tips (TS selfperception. selfperception self perception. perception selfmixing mixing design Inoffice In 5 minutes 0 ΔSGU, ΔSGU (ΔSGU) a=0.05. a005 a=0.05 . 05 (a=0.05) p>0.05. p005 p>0.05 (p>0.05) However MD 2.3 23 2 95 12 1 1. 3.3 33 0.001 0001 001 1.6 16 06 0. 2.6 26 0.03 003 03 45 tipwithoutbrush tipwithbrush odds 0.61 061 61 029 29 0.2 1.28 128 28 p<0.02, p002 p<0.02 02 p<0.02) 0.05 005 0.06 006 -0.0 0.17 017 17 p>0.36. p036 p>0.36 36 p>0.36) 1.3 13 -1.3 1.8 18 8 -1. 0.9 09 9 -0.9 p<0.001. p0001 p<0.001 p<0.001) (HP (ΔSGU a00 a=0.0 (a=0.05 p00 p>0.0 (p>0.05 2. 3. 0.00 000 0.0 4 p<0.0 -0. 0.1 01 p03 p>0.3 -1 p000 p<0.00 a0 a=0. (a=0.0 p0 p>0. (p>0.0 p<0. -0 - a=0 (a=0. p>0 (p>0. p<0 a= (a=0 p> (p>0 p< (a= (p> (a (p

Resumo Este estudo teve como objetivo quantificar a permeabilidade do peróxido de hidrogênio (PH), avaliação da mudança de cor, morfologia da superfície e composição de elementos após a aplicação de agentes dessensibilizantes antes do clareamento em consultório. Cinquenta pré-molares foram seccionados, um tampão de acetato foi colocado na câmara pulpar e divididos em cinco grupos (n=10). No grupo controle positivo, apenas o gel clareador em consultório foi utilizado e no grupo controle negativo nenhum tratamento foi realizado. Foram aplicados três agentes dessensibilizantes diferentes: grupo KF2%®; grupo Mi Paste® e Desensibilize Nano-P®. O procedimento de clareamento foi realizado com PH a 35%. A absorbância da solução resultante foi determinada em um espectrofotômetro. A mudança de cor foi avaliada utilizando um espectrofotômetro digital. Quatro pré-molares adicionais foram atribuídos aos mesmos grupos acima para análise em microscópio eletrônico de varredura, bem como para avaliar a composição elementar com espectrometria de energia dispersiva por raios-X. Os dados foram submetidos ao teste ANOVA e Tukey (a=0,05). Todos os produtos reduziram a penetração de PH na câmara pulpar. Mi Paste e Nano P foram os produtos que apresentaram a menor penetração de PH, semelhante ao grupo controle negativo (p<0,001). Nenhuma diferença significativa foi detectada na mudança de cor (p<0,001). Em relação à morfologia do esmalte, os grupos analisados após o clareamento apresentou maior deposição de agentes dessensibilizantes na superfície. O uso de agentes dessensibilizantes antes do clareamento dental parece ser uma alternativa para reduzir os efeitos adversos no dente.

Abstract This study aimed to quantify the penetration of hydrogen peroxide, color change evaluation, surface morphology, and composition after application of desensitizing agents before in-office bleaching. Fifty premolars were sectioned, an acetate buffer was placed in the pulp chamber and divided into five groups (n=10). In the positive control group, only the in-office bleaching gel was used, and in the negative control group, no treatment was used. Three different desensitizing agents were applied: Desensibilize KF2%® group; Mi Paste® group, and Desensibilize Nano-P® group. The bleaching procedure was carried out with 35% HP. The absorbance of the resulting solution was determined in a spectrophotometer. Color change was assessed by using a digital spectrophotometer. Four additional premolars were assigned to the same groups above for analysis under scanning electron microscope, as well as to evaluate the elemental composition with X-ray dispersive energy spectrometry. Data were subjected to ANOVA and Tukey's test (α=0.05). All products reduced the penetration of HP in the pulp chamber. Mi Paste and Nano P were the products that yielded the lowest HP penetration, which was similar to the negative control group (p<0.001). No significant difference was detected in color change (p<0.001). Concerning enamel morphology, the groups that were analyzed after bleaching were observed a greater deposition of desensitizing agents on the surface. The use of desensitizing agents before tooth bleaching seems to be an alternative to reduce adverse effects of the tooth.

Abstract Objectives This randomized, split-mouth, single-blinded trial assessed whether the use of reservoirs in at-home bleaching trays is equivalent to non-reservoir trays. Our choice of an equivalence trial was based on the expectation that a non-reservoir tray is sufficient to produce a color change. Secondary outcomes such as tooth sensitivity (TS) and gingival irritation (GI) were also assessed. Methodology Forty-six patients were selected with canines shade A2 or darker. In half of the patient’s arch, bleaching trays were made with reservoirs and the other half, without reservoirs. At-home bleaching was performed with carbamide peroxide (CP) 10% (3 h daily; 21 days). Color change was evaluated with a digital spectrophotometer (ΔE, ΔE00, and Whiteness Index) and shade guide units (ΔSGU) at baseline, during and one-month post-bleaching. TS and GI were assessed with a numeric scale (NRS) and a visual analog scale (VAS). Results After one month, the equivalence of reservoir and non-reservoir groups were observed in all color instruments (p>0.05). Fifteen and sixteen patients presented pain (absolute risk: 33% and 35%, 95%, confidence interval (CI) 21-46% and 23-49%) in the reservoir and non-reservoir side, respectively. The odds ratio for pain was 0.8 (95%CI 0.2-3.0) and the p-value was non-significant (p=1.0). TS intensity was similar between both groups in any of the pain scales (p>0.05). No difference in the GI was observed (p>0.05). Conclusions The protocol with reservoirs is equivalent in color change to the non-reservoir, although no superiority of the latter was observed in terms of reduced TS and GI with at-home 10% carbamide peroxide bleaching. Clinical Relevance The presence of reservoirs in a bleaching tray did not improve color change or affect tooth sensitivity and gingival irritation.