Abstract Artificial Intelligence is transforming Higher Education, achieving significant advances in different areas of knowledge. The OpenAI language model has revolutionized the world since November 2022. This study explores the potential of applying ChatGPT in academia. Documents available in the Web of Science, Scopus and Google Scholar are analyzed. The keywords “ChatGPT” and “Higher Education” are used using the “AND” operator, year 2023. The results of the bibliometric analysis reveal a considerable number of articles. When filters are applied, the number is significantly reduced. The subject is at an early stage in relation to HE. Publications in more than one database were identified, but not publication of an article in more than one journal; there is interest from researchers from different countries. Literature review studies are abundant. The advantages in terms of efficiency, quality and creativity in the generation of knowledge are highlighted. However, there are also ethical challenges and the need for responsible use. It is essential that educators and students are aware of the potential risks and take steps to mitigate them through ongoing training and the promotion of academic integrity. Education 2022 academia Science analyzed “ChatGPT AND “AND operator 2023 articles applied reduced HE identified journal countries abundant efficiency highlighted However use integrity 202 20 2

Abstract: OBJECTIVE The prevalence of eosinophilia in chronic obstructive pulmonary disease is of great importance for the prevention of complications and to treat episodes of overactivity. The existence of a bio-marker would allow this monitoring. The review of the literature reveals the possible eosinophilia-chronic obstructive pulmonary disease relationship. There is little information in medical studies. MATERIAL AND METHOD We designed a descriptive observational study of the population attended in the external consultation of Pneumology in the University Hospital of Puebla. The following variables were analyzed: age, sex, years of diagnosis of chronic obstructive pulmonary disease, blood count (diagnosis of eosinophilia with > 2% or more than 200 total cells), severity (by GOLD) and number of exacerbations in one year of study. RESULTS Fifty patients with a diagnosis of chronic obstructive pulmonary disease (74% female and 26% male), 50% associated with smoking and 50% associated with wood smoke were present; 36% had representative eosinophilia (greater than 2% or greater than 200 total cells), 64% had non-representative eosinophilia (less than 2% or less than 200 total cells). CONCLUSION This work demonstrates in a population the importance of eosinophilia as a biomarker in the phenotype of chronic obstructive pulmonary disease that allows adequate treatment and aimed at improving quality of life and to decrease the progression and appearance of complications and exacerbations.

Resumen: ANTECEDENTES La prevalencia de eosinofilia en la enfermedad pulmonar obstructiva crónica (EPOC) es de gran importancia para la prevención de complicaciones y tratar episodios de sobreagudización. La existencia de un biomarcador permitiría este seguimiento. La revisión de la bibliografía pone de manifiesto la posible relación eosinofilia-enfermedad pulmonar obstructiva crónica. Se tiene poca información en estudios médicos. MATERIAL Y MÉTODO Estudio descriptivo y observacional de la población atendida en la consulta externa de Neumología en el Hospital Universitario de Puebla. Se analizaron las siguientes variables: edad, sexo, años de diagnóstico de enfermedad pulmonar obstructiva crónica, hemograma (se estableció el diagnóstico de eosinofilia con > 2% o más de 200 células totales), gravedad (por GOLD) y número de exacerbaciones en un año de estudio. RESULTADOS Se incluyeron 50 pacientes con diagnóstico de enfermedad pulmonar obstructiva crónica (74% mujeres y 26% hombres), 50% asociado con tabaquismo y 50% asociado con humo de leña; 36% tenían eosinofilia representativa (mayor de 2% o mayor de 200 células totales), 64% tenían eosinofilia no representativa (menos de 2% o menos de 200 células totales). CONCLUSIÓN Este trabajo demuestra en una población la importancia de la eosinofilia como biomarcador en el fenotipo de la enfermedad pulmonar obstructiva crónica que permita el tratamiento adecuado y dirigido a mejorar la calidad de vida y a disminuir la progresión y aparición de complicaciones y exacerbaciones.