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Abstract Background: Extracranial internal carotid aneurysms are extremely rare and usually diagnosed as incidental findings although thromboembolic events or rupture can occur. Historically treated by open surgery, endovascular repair is emerging as an alternative. We present our center’s experience with both approaches. Case reports: Four internal carotid aneurysm cases are presented: Case 1 - 60-year-old male presented with an asymptomatic 20mm saccular aneurysm of the carotid bifurcation. He underwent arterial reconstruction with a bypass using a 6mm ePTFE graft and reimplantation of the external carotid artery. Case 2 - 61-year-old female presents with an asymptomatic 17mm saccular aneurysm of the internal carotid artery. Aneurismectomy and direct reconstruction through an end-to-end anastomosis was possible due to artery redundancy. Case 3 - 36-year-old patient with a history of Cushing's syndrome due to a secretory adenoma of the pituitary gland presented with an 19mm fusiform aneurysm of the internal carotid artery. After pituitary gland tumor recession, he underwent arterial reconstruction with an inlay saphenous vein bypass. Case 4 - 77-year-old female presents with a 27mm saccular aneurysm of the internal carotid artery. Endovascular aneurysm exclusion using a self-expandable covered stent was performed through a cervical carotid surgical approach. Stent occlusion was observed in the postoperative period but without neurological symptoms. Conclusion: Existing data on endovascular treatment’s short- and medium-term outcomes are comparable to surgery, but long-term results are unknown and high rates of technical failure have been associated to artery tortuosity. There are no specific guidelines to guide decision-making and treatment decisions must be individualized according to the morphology and location of the aneurysm and patient's comorbidities.

https://doi.org/10.48750/acv.555

Autolesión no suicida en población general: frecuencia y factores asociados en Paraguay
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Duarte-Arroyo, Araceli

; Barrios, Iván

; Torres-Romero, Anthon Daniel

; Caycho-Rodríguez, Tomás

; Ventriglio, Antonio

; Castaldelli-Maia, João Mauricio

; Torales*, Julio

Revista de salud publica del Paraguay

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Dez 2023, Volume 13 Nº 3 Páginas 29 - 35

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN Introducción: La investigación sobre la autolesión no suicida permite aumentar la conciencia sobre este fenómeno, posibilita su detección temprana y la implementación de estrategias más eficaces en prevención y tratamiento. Esto conlleva a una reducción del sufrimiento individual, los costos económicos y el impacto en la sociedad en su totalidad. Objetivo: Determinar la frecuencia y factores asociados a autolesión no suicida en una muestra de población adulta de Paraguay. Metodología: Estudio descriptivo de asociación cruzada, de corte transversal y prospectivo. Una encuesta en línea fue difundida a través de redes sociales y aplicaciones de mensajería. Esta incluía preguntas sobre datos sociodemográficos y clínicos. La presencia de autolesiones se determinó a través de la versión en español de la escala Self-Harm Questionnaire. Se utilizó estadística descriptiva para todas las variables. Para buscar asociaciones se utilizó la prueba chi cuadrado. Resultados: Participaron 241 personas (media de edad=32±12 años, 74,7% mujeres). Se encontró una frecuencia de autolesiones de 24,5% (n=59). De estos, el 91,5% había tenido ideación suicida al menos una vez. Se encontró asociación entre el nivel de ingresos y la frecuencia de autolesiones (χ^2=16,9 gl=2 p<0,001). Los principales factores asociados a autolesiones fueron tener un diagnóstico previo de algún trastorno mental (OR=4,81) e historia de abuso físico o sexual (OR=3,00). Conclusión: A través de esta investigación se determinó que casi uno de cada cuatro adultos participantes se autolesionaba. La mayoría había tenido ideas suicidas al menos una vez. Además, los ingresos por debajo del salario mínimo y factores como tener un trastorno mental previo e historial de abuso físico o sexual se asociaron con las autolesiones.

ABSTRACT Introduction: Research on non-suicidal self-injury raises awareness of this phenomenon, enabling the early detection and implementation of more effective strategies in prevention and treatment. This leads to a reduction in individual suffering, economic costs, and impact on society. Objective: To determine the frequency and associated factors of non-suicidal self-injury in a sample of the adult population of Paraguay. Methodology: This was a descriptive, cross-sectional, and prospective study. An online survey was disseminated through social networks and messaging applications. The survey included questions on sociodemographic and clinical data. The presence of self-injury was determined by using the Spanish version of the Self-Harm Questionnaire. Descriptive statistics were used for all the variables. The chi-square test was used to examine associations. Results: There were 241 participants (mean age=32±12 years, 74.7%female). A non-suicidal self-injury frequency of 24.5% (n=59) was observed. Of these, 91.5% reported suicidal ideation at least once. An association was found between income level and the frequency of non-suicidal self-injury (χ^2=16,9 gl=2 p<0,001). The main factors associated with non-suicidal self-injury were a previous diagnosis of a mental disorder (OR=4.81) and a history of physical or sexual abuse (OR=3.00). Conclusion: Through this research, it was determined that almost one in four adult participants self-injured. Most of them had had suicidal thoughts at least once. In addition, income below the minimum wage and factors such as a previous mental disorder and a history of physical or sexual abuse were associated with non-suicidal self-injury.

https://doi.org/10.18004/rspp.2023.dicie.05

Procrastinación académica en estudiantado de medicina del Paraguay en 2022
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Real Delor, Raúl Emilio

; Acosta Sánchez, Rilci Araceli

; Arrua Gaona, Charles Enrique

; Cabrera Dávalos, Luis Alberto

; Cáceres Huispe, Marcelo Agustín

; Correa Escobar, Laura Josefina

; Duarte Rodríguez, Mayra Alejandra

; Gómez, Orlando de Jesús

; Ortiz Villalba, David Israel

; Ramírez,, Johanna de María

; Ruiz Diaz Llanes, Jessica Nicoll

; Segovia Fernández, Daniel

; Trinidad Segovia, Oscar Danilo

; Monges Coiteux, Vanina Soldad

Revista Educación

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Dez 2023, Volume 47 Nº 2 Páginas 433 - 453

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen Los objetivos fueron evaluar el nivel de procrastinación académica del estudiantado de medicina del Paraguay en 2022 y describir sus características sociodemográficas. Se realizó un estudio observacional, de corte transversal. Se aplicó el cuestionario de García-Martínez y Silva (2019)constituido por 22 preguntas basadas en la escala de Likert, el cual fue difundido por las redes sociales de estudiantes de universidades públicas y privadas del Paraguay entre mayo y octubre 2022 . El nivel de procrastinación se determinó por las dimensiones postergación de tareas, autorregulación académica e influencia de la tecnología, además, se evaluaron variables sociodemográficas. Las variables fueron sometidas a un análisis factorial exploratorio para indagar las dimensiones subyacentes, constructos o variables latentes observadas. La investigación fue aprobada por el Comité de ética de la Universidad Privada del Este, Paraguay. Se encuestaron 188 estudiantes, con predominio del sexo femenino (64.9%). La edad media fue 24 ± 4 años, un 31.9% reside en Asunción, 81.4% carece de ingresos económicos propios. En conclusión, se detectó procrastinación en 73 estudiantes (38.8%) de medicina. Se recomienda investigar las causas de esta situación.

Abstract As main objectives, this research aims to determine the level of academic procrastination of medical students in Paraguay in 2022 and describe their sociodemographic characteristics. For this, the researchers conducted an observational cross-sectional study. Likewise, they applied the García-Martínez and Silva (2019) questionnaire, which was disseminated through the social networks of students from public and private universities in Paraguay between May and October 2022. Procrastination was determined with the dimensions of task postponement, academic self-regulation and the influence of technology using 22 questions, answered with a scale of Likert. Sociodemographic variables were also evaluated. The variables were submitted to an exploratory factor analysis to investigate the underlying dimensions, constructs, or latent variables observed. The research was approved by the Ethics Committee of the Universidad Privada del Este, Paraguay. The researchers surveyed 188 students, with a predominance of females (64.9%). The average age was 24 ± 4 years, 31.9% reside in Asunción, and 81.4% lack their own economic income. Procrastination was detected in 73 students (38.8%). In conclusion, procrastination was detected in 38.8% of medical students; therefore, it is recommended to investigate the causes of this situation.

https://doi.org/10.15517/revedu.v47i2.53617

Intraosseous lipoma
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Duarte, Márcio Luís

; Penteado Ribeiro, Daniel Pires

; de Queiroz Pereira da Silva, André

; Botelho Alvarenga, Simone

; Masson de Almeida Prado, José Luiz

Medicina (Buenos Aires)

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Dez 2023, Volume 83 Nº 6 Páginas 1034 - 1034

Resumo: En | Texto: En | PDF: En

Efectos de la edad relativa en selecciones femeninas de Colombia: caso juegos bolivarianos 2022
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Roa-Duarte, Daniel

; Bermúdez-Villareal, Rafael

; Arroyo-Moya, Wilson

Ciencias de la actividad física (Talca)

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Jun 2023, Volume 24 Nº 1 elocation 1

Resumo: En Pt Es | Texto: En Pt Es | PDF: En | PDF: Pt | PDF: Es

ABSTRACT Relative Age Effects (RAE) refer to those (dis)advantages and outcomes that stem primarily from an interaction between the date of birth and the dates used to logistically organize the participants. RAE is consistently prevalent in female sports contexts, with 25% more relatively older participants (Q1) than relatively younger participants (Q4). Our objective was to identify the RAE in the Colombian women's teams participating in the last Bolivarian Games (JB) (ODEBO, 2022). A total of n = 87 dates of birth were analyzed using the chi-square statistical test. The analysis allowed us to establish that there are no RAE in the female teams participating in JB (X2 = 12,2; p = 0,836). These findings are important in the context of Colombian women's sports and can be considered by organizations, and sports clubs, as well as in guidelines for the identification and Selection of sports talents.

RESUMO Os Efeitos da Idade Relativa (RAE) referem-se àquelas (des)vantagens e resultados que decorrem principalmente de uma interação entre a data de nascimento e as datas utilizadas para organizar logisticamente os participantes. O EIR é consistentemente prevalente em contextos esportivos femininos, com 25% mais participantes relativamente mais velhos (Q1) do que participantes relativamente mais jovens (Q4). Nosso objetivo foi identificar o RAE nas equipes femininas colombianas participantes dos últimos Jogos Bolivarianos (JB) (ODEBO, 2022). Um total de n = 87 datas de nascimento foram analisadas pelo teste estatístico do qui-quadrado. A análise permitiu estabelecer que não há EIR nas equipes femininas participantes do JB (X2 = 12,2; p = 0,836). Esses achados são importantes para o contexto do esporte feminino colombiano e podem ser levados em consideração pelas organizações e clubes esportivos, bem como nas diretrizes para a identificação e seleção de talentos esportivos.

RESUMEN Los efectos relativos de la edad (RAE) se refieren a aquellas (des)ventajas y resultados que proceden fundamentalmente de una interacción entre la fecha de nacimiento y las fechas utilizadas para organizar logísticamente a los participantes. Los RAE prevalecen constantemente en contextos deportivos femeninos, con un 25 % más de participantes relativamente mayores (Q1) que participantes relativamente más jóvenes (Q4). Nuestro objetivo fue identificar los RAE en las selecciones Colombia femeninas participantes en los últimos juegos Bolivarianos [JB] (Organización Deportiva Bolivariana [ODEBO], 2022). Se analizaron un total n = 87 fechas de nacimiento, utilizando la prueba estadística de chi-cuadrada. El análisis nos permitió establecer que no existen los RAE en las selecciones femeninas participantes en los JB (X2 = 12,2; p = 0,836). Estos hallazgos son importantes para el contexto del deporte femenino colombiano y pueden ser tenidos en cuenta por organizaciones, clubes deportivos, así como en lineamientos para la identificación y selección de talentos deportivos.

https://doi.org/10.29035/rcaf.24.1.1

Primer Consenso Nacional Intersociedades de Inmunización del Adulto. 2023
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Candia, Elena

; Samaniego, Stela

; Núñez, Duilio

; Guerín, Rebeca

; Olmedo, Rocío

; Pérez, Lis

; Rodríguez, Hernán

; Vicenti, Cristina

; Penayo, Analía

; Almirón, Desirée

; Benítez, Gustavo

; Lezcano, Virgilio

; Amarilla, Elianne

; Ortega Portillo, Edgar

; García, Noemí

; Giménez, María Belén

; Cipolla, Giulia

; Mongelós, Jeaninne

; Duarte, Mercedes

; Denis, Rita

; Andino, Lidiane

; Salinas, Víctor

; Armoa, Alba

; Alcaraz, Perla

; Mora, Doris

; Andrada, José Daniel

; León, Ricardo Antonio

; Ordano, Félix

; Rolón, Roger

; Echeverria, Mario

; Franco, Olga

; Irala, Elena

; Dávalos, Liza

; Marecos, Alberto

; Ibarrola, Dahiana

; Acosta, Juan

; Quiñonez, Vicente

; Martínez, Marcos

; Rotela Fisch, Verónica

; Valiente Rebull, Celeste

; Henegard, Sofía

; Guerrero, Alba

; Vázquez, Luz

; Roy, Tatiana

Revista del Instituto de Medicina Tropical

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Jun 2023, Volume 18 Nº 1 Páginas 96 - 119

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

SUMMARY Vaccines prevent millions of deaths each year, and their efficacy and safety have been widely established. In economic terms, vaccination is one of the most cost-effective health interventions, generating significant savings and long-term economic growth. Adult vaccination has been shown to decrease morbidity and mortality associated with preventable Infectious diseases, reducing complications and hospitalizations, including admissions to intensive care units. We have prepared this consensus document in order to design a pragmatic, accessible and standardized vaccination scheme for adults, according to risk category and age, based on the available evidence of available vaccines and new vaccines, having used the third consensus of the Paraguayan Infectious Diseases Society of 2019 as a basis for the final recommendations.

RESUMEN Las vacunas previenen millones de muertes cada año y su eficacia y seguridad han sido ampliamente establecidas. En términos económicos, la vacunación es una de las intervenciones sanitarias más costo efectivas, generando un importante ahorro y crecimiento económico que supone a largo plazo. Se ha demostrado que la vacunación de adultos disminuye la morbilidad y la mortalidad asociadas a enfermedades infecciosas prevenibles, reduciendo las complicaciones y las hospitalizaciones, incluidos los ingresos a las unidades de cuidados intensivos. Hemos elaborado este documento de consenso con el objeto de diseñar un esquema de vacunación pragmático, accesible y estandarizado del adulto, según categoría de riesgo y edad, sobre la base de la evidencia disponible de vacunas accesibles y nuevas vacunas habiendo utilizado el Tercer Consenso de la Sociedad Paraguaya de Infectología del 2019 como base para las recomendaciones finales.

https://doi.org/10.18004/imt/2023.18.1.14

Características de las lesiones retinianas en pacientes con diagnóstico de Toxoplasmosis ocular que acuden a un centro de referencia en oftalmología en Paraguay
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Vera-Duarte, Guillermo Raúl

; Delgado-Herrera, Claudia Leticia

; Castillo-Benítez, Verónica Elisa

; González-Sanabria, Luis

; Encina-López, Francisco Daniel

Medicina clínica y social

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Abr 2023, Volume 7 Nº 1 Páginas 11 - 16

Resumo: En Es | Texto: En Es | PDF: En | PDF: Es

ABSTRACT Introduction: Toxoplasmosis is a parasitic disease, in Latin America the prevalence is relatively high, it is known that the disease is not only the most frequent cause of posterior uveitis, but also the main cause of uveitis itself. In Paraguay there are no published epidemiological data on it. Objective: To determine the characteristics of retinal lesions in patients diagnosed with ocular Toxoplasmosis. Methods: This study is observational, descriptive, cross-sectional, temporally retrospective, with non-probabilistic sampling of consecutive cases. It focused on patients diagnosed with Toxoplasmosis who attended the Ophthalmology service of the Hospital de Clínicas, during the period from June 2020 to February 2022. Results: 54.3% of women were observed, an average of 30.62 +/ - 12.96 years old and 62.8% of urban origin. 88.3% of the cases were unilateral, half were primary episodes, 93.6% acute cases, and 97.9% had an acquired transmission mechanism. Most presented as panuveitis, the most frequent locations of retinochoroidal lesions were the posterior pole (extramacular) and the periphery. The main therapeutic approach was treatment with trimethoprim sulfamethoxazole and systemic corticosteroids, the duration of treatment was 6.51 +/- 1.52 weeks, and the main complications were residual vitritis and ocular hypertension. Discussion: Ocular toxoplasmosis is an important cause of visual morbidity. It is essential to prevent infection by this parasite through hygienic-sanitary measures, as well as early diagnosis and treatment of infected patients, in order to reduce the complications associated with this pathology.

RESUMEN Introducción: La toxoplasmosis es una enfermedad parasitaria, en América Latina la prevalencia es relativamente alta, se sabe que la enfermedad no solo es la causa más frecuente de uveítis posterior, sino también la causa principal de la uveítis en sí misma. En Paraguay no se dispone de datos epidemiológicos publicados sobre la misma. Objetivo: Determinar las características de las lesiones retinianas en pacientes con diagnóstico de Toxoplasmosis ocular. Metodología: El presente estudio es observacional, descriptivo, de corte transversal, temporalmente retrospectivo, con muestreo no probabilístico de casos consecutivos. Se enfocó en pacientes con diagnóstico de Toxoplasmosis que acudieron al servicio de Oftalmología del Hospital de Clínicas, durante el periodo de junio de 2020 a febrero 2022. Resultados: Se observó un 54,3 % de mujeres, una media de 30,62 +/- 12,96 años y un 62,8 % de procedencia urbana. El 88,3 % de los casos fueron unilaterales, la mitad de episodios primarios, el 93,6 % casos agudos, y el 97,9 % tuvo un mecanismo de trasmisión adquirido. La mayoría se presentó como Panuveítis, las localizaciones más frecuentes de las lesiones retinocoroideas fueron el Polo posterior (extramacular) y la periferia. El principal abordaje terapéutico fue el tratamiento con Trimetoprim Sulfametoxazol y corticoides sistémicos, la duración del tratamiento fue de 6,51 +/- 1,52 semanas, y las principales complicaciones fueron la Vitritis residual y la Hipertensión ocular. Discusión: La toxoplasmosis ocular es una causa importante de morbilidad visual. Se hace fundamental la prevención de la infección por este parásito mediante medidas higiénico-sanitarias, así como el diagnóstico y tratamiento precoz de los pacientes infectados, de tal manera a disminuir las complicaciones asociadas a esta patología.

https://doi.org/10.52379/mcs.v7i1.264

PNPLA3 GENE POLYMORPHISM AND RED MEAT CONSUMPTION INCREASED FIBROSIS RISK IN NASH BIOPSY-PROVEN PATIENTS UNDER MEDICAL FOLLOW-UP IN A TERTIARY CENTER IN SOUTHWEST BRAZIL
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YOSHIMURA, Silvia Massami

; DUARTE, Sebastião Mauro Bezerra

; STEFANO, José Tadeu

; MAZO, Daniel Ferraz de Campos

; PINHO, João Renato Rebello

; OLIVEIRA, Claudia P

Arquivos de Gastroenterologia

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Jan 2023, Volume 60 Nº 1 Páginas 98 - 105

Resumo: En Pt | Texto: En Pt | PDF: En | PDF: Pt

ABSTRACT Background: Recent studies show an increase in nonalcoholic fatty liver disease (NAFLD) in populations with higher consumption of red meat, processed and cooked at high temperatures. On the other hand, the single nucleotide polymorphism rs738409 in the Patatin-like phospholipase domain containing 3 (PNPLA3) gene has been implicated in susceptibility to NAFLD and liver fibrosis. However, the synergistic effect between red meat consumption and the PNPLA3 gene polymorphism in NAFLD has not yet been evaluated. Objective: To evaluate the association between the presence of the polymorphism in the PNPLA3 gene and the consumption of macronutrients, including meat consumption and its cooking method among NAFLD patients. Methods: This was a cross-sectional study with 91 patients diagnosed with NAFLD by liver biopsy with genotyping for the polymorphism in the PNPLA3 gene were included. The consumption of calories and macronutrients was verified using the semi-quantitative food frequency questionnaire and the specific questionnaire on meat consumption. PNPLA3 gene polymorphism was analyzed by real-time polymerase chain reaction (RT-PCR) and anthropometric evaluation was realized. Results: The mean BMI was 32.38±4.58 kg/m² and the waist circumference was 107±10 cm. On liver biopsy, 42% of patients had significant fibrosis (F≥2). The odds ratio of F≥2 was 2.12 for the GG group and 1.54 for the CG group, compared to the CC group. The mean caloric intake was 1170±463.20 kcal/d. The odds ratio in the CC group concerning high red meat consumption in comparison to low consumption was 1.33. For white meat, the odds ratio was 0.8 when comparing high and low intake, also in the CC group. Conclusion: High red meat intake and PNPLA3 gene polymorphism seem to synergistically affect NAFLD and liver fibrosis, requiring confirmation in a larger number of patients and in different populations.

RESUMO Contexto: Estudos recentes mostram um aumento da doença hepática gordurosa não alcoólica (DHGNA) em populações com maior consumo de carne vermelha, processada e cozida em altas temperaturas. Por outro lado, o polimorfismo rs738409 no gene Patatin-like fosfolipase contendo 3 (PNPLA3) tem sido implicado na suscetibilidade à DHGNA e fibrose hepática. No entanto, o efeito sinérgico entre o consumo de carne vermelha e o polimorfismo no gene PNPLA3 na DHGNA ainda não foi avaliado. Objetivo: Avaliar a associação entre a presença do polimorfismo no gene PNPLA3 e o consumo de macronutrientes, incluindo o consumo de carne e seu modo de cozimento em pacientes com DHGNA. Métodos: Realizamos um estudo transversal com 91 pacientes diagnosticados com DHGNA por biópsia hepática e genotipados para o polimorfismo no gene PNPLA3. O consumo de calorias e macronutrientes foi verificado por meio do questionário de frequência alimentar semi-quantitativo (QFA) e do questionário específico sobre consumo de carnes. O polimorfismo no gene PNPLA3 foi analisado por reação em cadeia da polimerase em tempo real (RT-PCR) e a avaliação antropométrica foi realizada. Resultados: O índice de massa corporal médio foi de 32,38±4,58 kg/m² e a circunferência da cintura foi de 107±10 cm. Na biópsia hepática, 42% dos pacientes apresentavam fibrose significativa (F≥2). O odds ratio de F≥2 foi de 2,12 para o grupo GG e 1,54 para o grupo GC, comparado ao grupo CC. A ingestão calórica média foi de 1.170±463,20 kcal/d. O odds ratio para alto consumo de carne vermelha no grupo CC em comparação ao baixo consumo foi de 1,33. Para a carne branca, este valor foi de 0,8 ao comparar o alto e o baixo consumo, também no grupo CC. Conclusão: A alta ingestão de carne vermelha e o polimorfismo no gene PNPLA3 parecem afetar sinergicamente a DHGNA e a fibrose hepática, necessitando de confirmação em maior número de pacientes e em diferentes populações.

https://doi.org/10.1590/s0004-2803.202301000-13

Agroclimatic zoning of the state of Nayarit, Mexico
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Mendoza-Cariño, Mayra

; Bautista-Olivas, Ana Laura

; Mendoza-Cariño, Daniel

; Ortiz-Solorio, Carlos Alberto

; Duarte-Tagles, Héctor

; Cruz-Flores, Gerardo

Atmósfera

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2023, Volume 36 Nº 1 Páginas 123 - 142

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

RESUMEN La productividad agrícola del estado de Nayarit ha disminuido desde 1998. El objetivo de este estudio fue realizar la zonificación agroclimática del estado y determinar los cultivos que se pueden producir con mayores beneficios, según el sistema de clasificación climática de Papadakis. Para ello, se utilizaron características hídricas y térmicas, e índices derivados de valores meteorológicos de 25 estaciones climatológicas que limitan la distribución geográfica de los cultivos. Los grupos climáticos establecidos fueron tres: tropical, subtropical y tierra fría con cuatro, tres y dos subgrupos cada uno, respectivamente. Los dos primeros favorecen los cultivos de cereales de invierno como avena (Avena sativa L.), cebada (Hordeum vulgare L.), centeno (Secale cereale L.) y trigo (Triticum aestivum L.); y de verano como arroz (Oryza sativa L.), maíz (Zea mays L.), mijo (Panicum italicum L.) y sorgo (Sorghum bicolor (L.) Moench), además de banana (Musa paradisiaca L.), caña de azúcar (Saccharum officinarum L.), cítricos y papa (Solanum tuberosum L.). En el grupo climático de tierra fría, se encontraron maíz y papa. Con base en el método Papadakis, para cada subgrupo climático identificado se indicaron los cuidados necesarios para obtener buenos rendimientos (tipo de cultivo; épocas de siembra; aplicación de riego, fertilizantes y agroquímicos) y para evitar problemas fitosanitarios y de almacenamiento después de la cosecha. El mapa de zonificación agroclimática se generó con el método de interpolación de la distancia inversa ponderada. Este estudio puede ser la base para planificar con éxito los cultivos en la región y mejorar la economía del estado.

ABSTRACT Agriculture productivity in the state of Nayarit has decreased since 1998. The aim of this study was to undertake the agroclimatic zoning across the state in order to determine the type of crops more convenient to render the highest yields, based on the Papadakis climate classification system. Hydric and thermal characteristics pertaining to the geographic distribution of crops were used, as well as indexes derived from meteorological data provided by 25 climate stations. There were three climatic groups identified: tropical, subtropical and cold land, having four, three and two subgroups each, respectively. The first two climatic groups support winter cereals such as oat (Avena sativa L.), barley (Hordeum vulgare L.), rye (Secale cereale L.) and wheat (Triticum aestivum L.); and summer cereals such as corn (Zea mays L.), millet (Panicum italicum L.), rice (Oryza sativa L.) and sorghum (Sorghum bicolor [L.] Moench), in addition to banana (Musa paradisiaca L.), citrus, potato (Solanum tuberosum L.) and sugar cane (Saccharum officinarum L.). On the other hand, corn and potato were found in the cold land climatic group. Based on the methodology of Papadakis, for each climatic sub-group identified, a set of recommendation managements were given to improve yields (crop type, sowing season, irrigation, fertilizing and other agrochemicals application) and to avoid crop damage. An agroclimatic-zoning map was generated by using the inverse distance weighted interpolation method. This study may contribute to the successful planning of crops across the region and thus to improve the state’s economy.

https://doi.org/10.20937/atm.53002

10.

Oral mucositis and microbial status in acute lymphoblastic leukemia subjects undergoing high-dose chemotherapy
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Duarte, Ana Cláudia Nunes

; Barbosa, Anderson Nogueira

; Saito, Cristiane Pereira Borges

; Paula, Erich Vinicius de

; Saito, Daniel

Brazilian Journal of Oral Sciences

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2023, Volume 22 elocation e237697

Resumo: En | Texto: En | PDF: En

Aim To assess oral microbial status in patients with acute lymphoblastic leukemia (ALL) undergoing high-dose chemotherapy and to unravel possible associations between nosocomial pathogens and the establishment of chemotherapy-induced oral mucositis (CIOM). Methods Oral mucosa, saliva, and peripheral blood samples were collected from 46 ALL subjects one day prior to chemotherapy (D0) and 2 weeks after treatment initiation (D14). Clinical intraoral inspection was performed by a single practitioner, with mucositis classification performed according to the WHO oral toxicity scale. Blood components were quantified by automatic flow cytometry, while oral Staphylococcus aureus and Pseudomonas aeruginosa were detected by Polymerase Chain Reaction with species-specific primers. Associations among bacteria and clinical findings were determined by Fisher’s Exact test, longitudinal bacterial changes by paired Macnemar, and correlations among blood parameters and mucositis status or bacteria via Mann-Whitney. Results S. aureus displayed higher detection rates at D14 (p < 0.05) and was positively associated with mucositis, adoption of a non-solid diet (all p < 0.001), nausea and fever (all p < 0.05). Conversely, P. aeruginosa did not correlate to CIOM clinical parameters. At the systemic standpoint, lower hemoglobin levels associated with CIOM and fever events (all p < 0.01). Conclusion The study evidences S. aureus as a potential pathogen in ALL-CIOM, reaffirming microbial control as an important preventive measure during high-dose immunosuppressive therapy. The weight of non-white-blood-cell parameters should be validated as novel CIOM biomarkers in prospective research.

https://doi.org/10.20396/bjos.v22i00.8667697

11.

Development and validation of an analytical method by HPLC-DAD for determination of caffeine in products based on guarana extracts (Paullinia cupana)
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Moura-Silva, Anna Kelly

; Mano-Sousa, Brayan Jonas

; Santos, Lays Pedrosa

; Costa, Rafael Serrão da

; Andrade, Frank Pereira de

; Duarte-Almeida, Joaquim Maurício

; Gonçalves, Daniel Bonoto

Brazilian Journal of Pharmaceutical Sciences

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2023, Volume 59 elocation e22106

Resumo: En | Texto: En | PDF: En

Abstract Guarana (Paullinia cupana) is a native plant from the Amazon whose seeds contain a high concentration of caffeine. Aqueous extract of guarana is widely used in the world. In this study, the objective was to develop and validate a High-Performance Liquid Chromatography method for the determination of caffeine in extracts and commercial beverages based on guarana. A sensitive, simple, and viable high performance liquid chromatographic method without the need of an analyte extraction procedure was developed and validated according to Brazilian and international requirements. The method presented high performance, fulfilling Brazilian and international requirements, in addition to allowing product compliance tests. Results confirmed high selectivity and linearity (>0.999) between 5 to 135 ug/mL, with no significant matrix effect. Detection and quantification limits were 0.02 µg/mL and 2 µg/mL, respectively. Precision was less than 4 %, and accuracy varied from 99.9-120 %. Applicability of the method was demonstrated by conducting a limited evaluation in products containing caffeine. Commercial extracts showed quite different caffeine levels, while carbonated drinks follow Brazilian and American recommendations. Our results indicate that the developed method can be used to evaluate the quality of the guarana extract and of products containing caffeine.

https://doi.org/10.1590/s2175-97902023e22106

12.

Intra-genotypic variability in elite parent lines of papaya
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RODRIGUES, ALEX S.

; RAMOS, HELAINE C.C.

; MIRANDA, DANIEL P.

; PIROVANI, ADRIANA A.V.

; SANTA-CATARINA, RENATO

; DUARTE, RAFAELA P.

; BRAGA, CATIANE S.

; BOHRY, DIEIMES

; PEREIRA, MESSIAS G.

Anais da Academia Brasileira de Ciências

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2023, Volume 95 Nº 1 elocation e20220468

Resumo: En | Texto: En | PDF: En

Abstract This study aimed to characterize papaya lines via microsatellite markers, and select genotypes based on the fixation index in order to promote the genetic purification of important commercial hybrids parent lines. Overall, 400 genotypes from three parental lines (JS-12, SS-72/12, and Sekati) were genotyped. Expected (HE), observed (HO) heterozygosity, and fixation index (F), were estimated. Genetic distances were estimated using an unweighted index, which was graphically presented via cluster analysis using the UPGMA and PCoA. Intra-genotypic variability was detected in both JS-12 and Sekati lines, while an absence of it was observed in SS-72/12. Such variability may positively contribute to the fitting of ‘UENF/Caliman 01’ and ‘UC-10’ hybrids into the traits of commercial interest how size and weight fruit. Regarding the fixation index, 293 genotypes showed maximum values (F=1) facilitating the genotypes selection process. Concerning population analysis, a close proximity between heterotic group ‘Formosa’ lines was observed, while a greater distance among ‘Solo’ group ones, and this enables systematic exploitation of such material. The fixation index maximum enabled the 80 genotypes selection thereby contributing to the parents genetic purification, since, the selected genotypes will be used in future hybridization steps to generate hybrids fitted into the traits of commercial interest.

https://doi.org/10.1590/0001-3765202320220468

13.

EPIDEMIOLOGICAL PROFILE IN A TERTIARY ADMISSION UNIT OF SPINE DISEASES
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COIMBRA, BRIAN GUILHERME MONTEIRO MARTA

; FREITAS, MATHEUS TRINDADE BRUXELAS DE

; LIMA, RAFAELA PEREIRA DE

; PERINI, DANIEL DUARTE

; BARROS FILHO, TARCíSIO ELOY PESSOA DE

; CRISTANTE, ALEXANDRE FOGAçA

; MARCON, RAPHAEL MARTUS

Coluna/Columna

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2023, Volume 22 Nº 3 elocation e272944

Resumo: En Es Pt | Texto: En Es Pt | PDF: En | PDF: Es | PDF: Pt

ABSTRACT Introduction: In March 2020, WHO officially decreed that the world was going through a pandemic, that of Covid-19. In May 2022, in Brazil, the end of measures to deal with the pandemic was decreed. In 2022, there was a movement to return to normal care in the provision of care. Objective: In the present study, we carried out a retrospective descriptive analysis of the epidemiological scenario of the ward of the Spine Group at the Hospital das Clínicas of the Faculty of Medicine of the Universidade de São Paulo (HC-FMUSP). Method: Data analysis was performed from information gathered in patients’ medical records. Results: In the analyzed period, there were 152 consultations in hospitalization, with the main cause being spinal trauma. Of all the cases, only 23.68% were scheduled on an elective basis, which despite being a lower than expected number, was shaped by the demands of urgent care channeled to the service in question. Conclusion: Despite a higher number of cases hospitalized in the post-pandemic period, there is still the expectancy of more elective cases to be treated in the future. Level of Evidence III; Retrospective Case Series Study.

RESUMEN Introdución: En marzo de 2020, la OMS decretó oficialmente que el mundo atravesaba una pandemia, la del Covid-19. En mayo de 2022, en Brasil, se decretó el fin de las medidas para enfrentar la pandemia. En el año 2022, hubo un movimiento para volver a la atención normal en la prestación de cuidados. Objetivo: En el presente estudio, realizamos un análisis descriptivo retrospectivo del escenario epidemiológico de la sala del Grupo de Columna Vertebral del Hospital das Clínicas de la Facultad de Medicina de la Universidade de São Paulo (HC-FMUSP). Método: El análisis de los datos se realizó con acceso al prontuario médico de los pacientes. Resultados: En el período analizado, hubo 152 consultas en hospitalización, siendo la principal causa trauma espinal. Del total de casos, solo el 23,68% fueron programados de forma electiva que, a pesar de ser un número inferior al esperado, estuvo condicionado por las demandas de atención urgente canalizadas al servicio en cuestión. Conclusión: A pesar del aumento de asistencias en el período postpandemia, hay espacio para una mayor recuperación futura en el volumen de casos electivos. Nivel de Evidencia III; Estudio Retrospectivo de Serie de Casos.

RESUMO Introdução: Em março de 2020, a OMS decretou oficialmente que o mundo atravessava uma pandemia, a Covid-19. Em maio de 2022, no Brasil, decretou-se o fim das medidas de enfrentamento à pandemia. No ano de 2022, houve um movimento de retorno à normalidade assistencial na prestação de atendimentos. Objetivo: No presente estudo, realiza-se uma análise retrospectiva descritiva do cenário epidemiológico da enfermaria do Grupo de Coluna Vertebral do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP). Método: A análise dos dados foi efetuada a partir do levantamento de prontuários médicos. Resultados: No período analisado, houveram 152 atendimentos em regime de internação, com a principal causa sendo o traumatismo da coluna vertebral. De todos os casos, apenas 23,68% foram casos agendados em regime eletivo, o que apesar de ser um número abaixo do esperado, foi moldado pelas demandas dos atendimentos de urgência canalizados ao serviço em questão. Conclusão: Apesar do aumento de atendimentos no período pós pandemia, há espaço para maior retomada do volume de casos eletivos no futuro. Nível de Evidência III; Estudo Retrospectivo de Série de Casos.

https://doi.org/10.1590/s1808-185120222203272944

14.

Consensus on the therapeutic management of atopic dermatitis ‒ Brazilian Society of Dermatology: an update on phototherapy and systemic therapy using e-Delphi technique
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Orfali, Raquel Leao

; Lorenzini, Daniel

; Bressan, Aline

; Tanaka, Anber Ancel

; Cerqueira, Ana Maria Mósca de

; Hirayama, André da Silva

; Ramos, Andréa Machado Coelho

; Proença, Carolina Contin

; Silva, Claudia Marcia de Resende

; Laczynski, Cristina Marta Maria

; Carneiro, Francisca Regina

; Duarte, Gleison

; Hans Filho, Gunter

; Gonçalves, Heitor de Sá

; Melo, Ligia Pessoa de

; Azulay-Abulafia, Luna

; Weber, Magda Blessmann

; Rivitti-Machado, Maria Cecília

; Zaniboni, Mariana Colombini

; Ogawa, Marília

; Pires, Mario Cezar

; Ianhez, Mayra

; Felix, Paulo Antonio Oldani

; Bonamigo, Renan

; Takaoka, Roberto

; Lazzarini, Rosana

; Cestari, Silmara

; Mayor, Silvia Assumpção Soutto

; Cestari, Tania

; Oliveira, Zilda Najjar Prado de

; Spuls, Phyllis I.

; Gerbens, Louise A.A.

; Aoki, Valeria

Anais Brasileiros de Dermatologia

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2023, Volume 98 Nº 6 Páginas 814 - 836

Resumo: En | Texto: En | PDF: En

Abstract This publication is an update of the “Consensus on the therapeutic management of atopic dermatitis - Brazilian Society of Dermatology” published in 2019, considering the novel, targeted-oriented systemic therapies for atopic dermatitis. The initial recommendations of the current consensus for systemic treatment of patients with atopic dermatitis were based on a recent review of scientific published data and a consensus was reached after voting. The Brazilian Society of Dermatology invited 31 experts from all regions of Brazil and 2 international experts on atopic dermatitis who fully contributed to the process. The methods included an e-Delphi study to avoid bias, a literature search and a final consensus meeting. The authors added novel approved drugs in Brazil and the indication for phototherapy and systemic therapy for AD. The therapeutical response to systemic treatment is hereby reported in a suitable form for clinical practice and is also part of this updated manuscript.

https://doi.org/10.1016/j.abd.2023.04.003

15.

Prevalencia y parasitemia sanguínea de palomas turcas (Streptopelia decaocto) y huilotas (Zenaida macroura) en Durango, México
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Salazar-Borunda, Manuel

; Martínez-Guerrero, José

; Martínez-Montoya, Juan

; Vargas-Duarte, Andrea

; Sierra-Franco, Daniel

; Pereda-Solís, Martín

Abanico veterinario

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Dez 2022, Volume 12 elocation 401

Resumo: Es En | Texto: Es En | PDF: Es | PDF: En

Resumen El parasitismo sanguíneo en aves de México es un fenómeno poco estudiado y su presencia en muchas especies de aves es desconocida. En este estudio, se compararon la prevalencia y parasitemia de hemosporidios en la época reproductiva (húmeda) y no reproductiva (seca) de las palomas turcas (Streptopelia decaocto) y huilotas (Zenaida macroura) del norte de México. Se analizó la sangre de 40 aves de cada especie, colectadas entre 2013 y 2014. El diagnóstico de hemoparásitos se realizó mediante técnicas de microscopía y reacción en cadena de la polimerasa (PCR). La prevalencia de hemoparásitos fue de 87.5 % (IC 95%=78.3-93.3). La parasitemia promedio fue de 7.03 (IC 95 %= 5.68-9.04) hemoparásitos por cada 10,000 eritrocitos infectados. La prevalencia y parasitemia fueron mayores para Haemoproteus sp. que en Plasmodium sp y microfilarias. Las tasas de prevalencia no variaron entre especies de aves, ni entre épocas del año. No obstante, la estacionalidad parece ser un factor importante en la parasitemia. La especie que obtuvo mayores tasas de parasitemia fue Z. macoura. Se necesitan más estudios para comprender los mecanismos que asocian la parasitemia de esta especie con respecto a otras especies de columbiformes.

Abstract Blood parasitism in Mexican birds is an impoverished-studied phenomenon, and its presence in many species of birds is unknown. In this study, the prevalence and parasitaemia of hemosporidia were compared in the breeding (wet) and non-breeding (dry) seasons in the Eurasian collared doves (Streptopelia decaocto) and Mourning ones (Zenaida macroura) in northern Mexico. The blood of 40 birds of each species collected between 2013 and 2014, was analyzed. The diagnosis of hemoparasites was made by microscopy and Polymerase Chain Reaction (PCR) techniques. The prevalence of hemoparasites was 87.5% (CI 95% = 78.3-93.3). The mean parasitaemia was 7.03 (CI 95% = 5.68- 9.04) hemoparasites per 10,000 infected erythrocytes. The prevalence and parasitaemia were higher for Haemoproteus sp. than for Plasmodium sp and microfilariae. The prevalence rates did not vary between bird species, nor between times of the year. However, seasonality seems to be an important factor in parasitaemia. The species that obtained the highest rates of parasitaemia was Z. macoura. More studies are needed to understand the mechanisms that associate parasitaemia in this species with respect to other columbiform species.

https://doi.org/10.21929/abavet2022.4

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